Hub : Genes

Slco2a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000009005	0.11	0.07	5.3e-06	0.04	0.03	0.03	0.03	2.4e-05	1.2e-04	1.8e-04	1.1e-04
2	Brain	gene expression	ENSRNOG00000009005	0.03	0.02	6.5e-03	0	0.01	0.01	0	2.0e-01	4.1e-02	8.5e-02	1.7e-01
3	Liver	intron excision ratio	chr8:103637317:103654517	0.09	0.05	2.6e-05	0.04	0.04	0.04	0.04	1.2e-05	5.0e-05	3.6e-05	1.9e-05
4	Liver	intron excision ratio	chr8:103641675:103654517	0.08	0.05	8.9e-04	0.03	0.02	0.02	0.02	7.2e-04	1.3e-03	2.9e-03	1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	0.9	2.9	3.5	-1.4	-1.6	-1.9	1.9
BMI without tail	3.9	8.1	9.2	-2.6	-2.7	-3.0	3.0
Body weight	3.4	14.4	16.3	-3.6	-3.5	-4.0	4.0
Epididymis fat weight	0.2	0.4	0.6	-0.3	-0.8	-0.7	0.7
Glucose	4.5	6.9	7.8	-2.7	-2.1	-2.8	2.8
Heart weight	0.5	0.8	1.1	-0.6	-1.0	-0.9	0.9
Left kidney weight	0.4	1.2	2.8	-0.5	-1.7	-1.0	1.0
Right kidney weight	0.3	0.8	1.1	-0.6	-1.1	-1.0	1.0
Tail length	3.6	11.0	11.7	-3.4	-3.1	-3.4	3.4
Length with tail	3.0	11.0	12.1	-3.5	-3.1	-3.4	3.4
Length without tail	0.5	1.2	1.5	-1.2	-1.0	-1.0	1.0
Liver weight, left	0.0	0.1	0.1	0.3	0.2	0.2	-0.2
Liver weight, right	0.4	0.7	1.0	-0.7	-0.7	-1.0	1.0
Parametrial fat weight	1.9	3.7	4.1	-2.0	-1.8	-1.9	1.9
Retroperitoneal fat weight	0.7	2.4	3.4	-1.7	-0.4	-1.8	1.8
Intraocular pressure	0.1	0.2	0.7	0.3	-0.8	0.1	-0.1
Extensor digitorum longus weight	0.2	0.9	1.4	-1.0	0.0	-1.2	1.2
Soleus weight	8.4	24.6	26.8	-5.1	-4.4	-5.2	5.2
Tibialis anterior weight	0.0	0.0	0.1	-0.1	0.3	0.0	-0.0
Tibia length	0.2	0.6	2.2	-0.2	-1.5	-0.3	0.3
Number of licking bursts	0.1	0.2	0.3	-0.2	-0.6	-0.4	0.4
Food consumed during 24 hour testing period	0.8	1.0	1.5	-0.8	-1.2	-0.9	0.9
Times rat made contact with spout	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.0
Mean time between licks in bursts	0.5	0.6	1.1	0.7	1.0	0.7	-0.7
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2
Std. dev. time between licks in bursts	3.5	4.2	6.7	1.8	2.6	1.8	-1.8
Water consumed over 24 hours	0.1	0.1	0.1	0.3	-0.2	0.4	-0.4
Indifference point 0 sec	0.1	0.2	0.4	-0.3	-0.6	-0.3	0.3
Indifference point AUC	0.4	0.4	1.3	0.6	1.1	0.1	-0.1
Indifference point function ln k	0.1	0.2	0.2	0.1	-0.5	0.5	-0.5
Indifference point function log k	0.1	0.2	0.2	0.1	-0.5	0.5	-0.5
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	0.1	-0.2	-0.0	0.0
Delay discounting total patch changes 12 sec	0.2	0.3	0.7	0.6	0.8	0.2	-0.2
Delay discounting total patch changes 18 sec	0.5	0.6	0.7	-0.7	-0.7	-0.8	0.8
Delay discounting total patch changes 24 sec	0.0	0.0	0.0	-0.0	0.2	-0.2	0.2
Delay discounting total patch changes 6 sec	0.1	0.2	0.4	0.7	0.2	0.4	-0.4
Delay discounting time to switch 0 sec	0.1	0.2	0.5	-0.3	-0.7	-0.3	0.3
Delay discounting water rate 0 sec	0.2	0.4	0.6	-0.6	0.2	-0.8	0.8
Delay discounting water rate 12 sec	1.9	2.8	3.7	-1.4	-1.3	-1.9	1.9
Delay discounting water rate 18 sec	1.6	2.2	2.7	-1.3	-1.3	-1.6	1.6
Delay discounting water rate 24 sec	1.0	1.4	1.8	-1.4	-1.1	-1.1	1.1
Delay discounting water rate 6 sec	1.5	2.2	2.9	-1.4	-0.9	-1.7	1.7
Locomotor activity	1.2	2.0	2.3	-1.3	-1.3	-1.5	1.5
Locomotor testing distance	1.7	2.8	3.2	-1.6	-1.8	-1.7	1.7
Locomotor testing rearing	0.2	0.3	0.6	0.6	0.8	0.3	-0.3
Light reinforcement 1	1.3	2.4	4.3	-2.1	-0.7	-1.5	1.5
Light reinforcement 2	2.9	3.8	5.2	-2.3	-1.7	-1.9	1.9
Reaction time number correct	0.4	0.5	0.6	-0.7	-0.5	-0.8	0.8
Reaction time mean minus median	0.2	0.2	0.5	0.7	0.6	-0.1	0.1
Reaction time mean minus median AUC	0.2	0.3	0.5	0.1	0.4	-0.7	0.7
Reaction time num false alarms	0.6	0.8	1.2	0.7	1.1	0.9	-0.9
Reaction time num false alarms AUC	0.2	0.3	0.5	0.3	0.7	0.6	-0.6
Reaction time trials correct on left	0.4	0.5	0.6	-0.7	-0.5	-0.8	0.8
Reaction time trials on left	0.4	0.5	0.7	-0.7	-0.5	-0.8	0.8
Reaction time mean	0.7	1.0	1.8	1.4	1.0	0.7	-0.7
Reaction time mean AUC	0.8	1.1	2.0	1.4	0.9	0.8	-0.8
Median of all reaction times	0.8	1.1	1.9	1.4	0.9	1.0	-1.0
Reaction time omissions	0.3	0.5	1.2	0.5	1.1	0.4	-0.4
Reaction time false alarm rate	0.3	0.5	0.6	0.5	0.8	0.7	-0.7
Reaction time premature initiation rate	3.7	4.9	7.2	-2.7	-1.0	-2.4	2.4
Reaction time premature initiations	3.5	4.9	6.9	-2.6	-1.0	-2.4	2.4
Std. dev. reaction times	0.6	0.8	1.6	1.3	1.0	0.5	-0.5
Reaction time trials completed	0.4	0.5	0.7	-0.7	-0.5	-0.8	0.8
Reaction time trials AUC	0.4	0.6	0.8	-0.8	-0.6	-0.9	0.9
Social response proportion	0.2	0.2	0.4	0.4	0.6	0.3	-0.3
Social responses	0.2	0.3	0.4	-0.6	0.6	-0.5	0.5
Social time	3.4	4.4	5.4	2.3	2.3	1.9	-1.9
Conditioned locomotion	0.1	0.2	0.2	0.4	0.0	0.5	-0.5
Cocaine response after cond. corrected	0.2	0.3	0.4	-0.4	0.3	-0.6	0.6
Cocaine response after cond. not corrected	0.4	0.5	0.7	-0.6	0.0	-0.9	0.9
Cocaine response before conditioning	0.3	0.3	0.7	-0.6	-0.8	-0.4	0.4
Saline control response	1.4	1.9	2.8	-1.2	-1.7	-1.3	1.3
Condit. Reinf. active minus inactive responses	1.8	2.2	4.4	1.5	2.1	1.0	-1.0
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.2	0.7	-0.6	0.6
Condit. Reinf. active responses	2.6	3.6	6.7	1.8	2.6	1.5	-1.5
Condit. Reinf. inactive responses	4.9	6.1	6.6	2.4	2.4	2.6	-2.6
Condit. Reinf. lever presses	1.6	2.2	4.2	1.3	2.1	1.2	-1.2
Condit. Reinf. lever reinforcers received	2.8	3.9	7.3	1.8	2.7	1.6	-1.6
Pavlov. Cond. lever latency	2.4	3.3	6.2	-1.7	-2.5	-1.5	1.5
Pavlov. Cond. magazine entry latency	2.7	3.1	3.9	1.6	2.0	1.7	-1.7
Pavlov. Cond. change in total contacts	1.9	2.7	5.6	1.3	2.4	1.3	-1.3
Pavlov. Cond. index score	2.9	3.8	5.9	1.8	2.4	1.8	-1.8
Pavlov. Cond. latency score	3.2	4.0	5.5	1.8	2.4	1.9	-1.9
Pavlov. Cond. lever contacts	2.2	3.1	5.2	1.7	2.3	1.5	-1.5
Pavlov. Cond. magazine entry number	5.1	6.3	8.2	-2.3	-2.9	-2.4	2.4
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.5	1.0	1.2	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.1	6.6	1.8	2.6	1.8	-1.8
Pavlov. Cond. response bias	3.5	4.9	8.7	2.0	3.0	1.8	-1.8
Conditioned reinforcement - actives	3.1	3.1	4.2	-2.0	-1.7	-1.7	1.7
Conditioned reinforcement - inactives	1.5	1.7	2.0	-1.1	-1.3	-1.4	1.4
Conditioned locomotion	0.3	0.4	0.8	-0.8	-0.9	-0.3	0.3
Intermittent access intake day 1-15 change	1.9	1.9	2.8	-1.3	-0.5	-1.7	1.7
Intermittent access intake escalation	2.6	2.6	3.6	-1.5	-0.9	-1.9	1.9
Intermittent access intake escalation 2	0.7	0.7	1.0	-0.8	-0.3	-1.0	1.0
Intermitt. access day 1 inactive lever presses	0.4	0.4	0.6	0.3	0.5	0.8	-0.8
Intermitt. access day 15 inactive lever presses	1.1	1.2	2.1	0.5	0.7	1.5	-1.5
Intermitt. access escalation Index	0.3	0.2	0.8	0.9	-0.1	-0.3	0.3
Intermittent access day 1 total infusions	1.0	1.2	2.2	-1.5	-1.2	-0.7	0.7
Intermittent access day 15 total infusions	3.1	3.4	4.2	-2.1	-1.4	-2.0	2.0
Intermittent access terminal intake (last 3 days)	5.4	5.9	7.8	-2.8	-2.0	-2.4	2.4
Intermittent access total infusions	3.5	3.9	5.0	-2.2	-1.9	-1.9	1.9
Intermittent access day 1 locomotion	0.3	0.3	0.7	-0.9	-0.4	-0.3	0.3
Intermittent access day 15 total locomotion	3.8	4.1	5.0	-2.2	-2.0	-1.9	1.9
Intermittent access total locomotion	2.2	2.5	3.9	-2.0	-1.5	-1.3	1.3
Intermittent access standard deviation	0.3	0.4	0.7	-0.8	0.8	0.3	-0.3
Cocaine induced anxiety	0.1	0.1	0.1	-0.3	-0.4	-0.2	0.2
Post-drug Anxiety	0.1	0.1	0.2	-0.5	-0.3	-0.2	0.2
Baseline Anxiety	0.0	0.0	0.0	-0.2	-0.1	-0.2	0.2
Lifetime Intake	3.0	3.3	4.2	-2.1	-1.7	-1.8	1.8
Incentive Sensitization - Responses	2.3	2.3	3.4	-1.9	-1.5	-1.3	1.3
Incentive Sensitization - Breakpoint	2.0	2.0	3.1	-1.7	-1.4	-1.2	1.2
Progressive ratio test 1 active lever presses	1.3	1.3	1.7	-1.1	-1.3	-1.1	1.1
Progressive ratio test 1 breakpoint	1.5	1.5	1.7	-1.2	-1.3	-1.2	1.2
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.3	-0.6	-0.6	-0.2	0.2
Progressive ratio test 2 active lever presses	4.0	4.3	5.0	-2.2	-2.1	-2.0	2.0
Progressive ratio test 2 breakpoint	3.1	3.4	3.9	-2.0	-1.7	-1.8	1.8
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.6	-1.3	-0.7	-0.6	0.6
Total sessions with >9 infusions	0.1	0.1	0.2	-0.5	-0.3	-0.3	0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.1	0.1	-0.4	0.2	-0.2
Short access day 10 total inactive lever presses	1.1	1.2	1.2	1.0	1.1	1.1	-1.1
Short access day 1 total infusions	0.2	0.2	0.4	-0.5	-0.6	-0.3	0.3
Short access day 10 total infusions	2.8	3.1	4.5	-2.1	-1.6	-1.6	1.6
Short access total infusions	1.4	1.5	1.6	-1.2	-1.2	-1.3	1.3
Short access day 1 locomotion	1.9	2.0	2.1	-1.3	-1.4	-1.5	1.5
Short access day 10 total locomotion	0.2	0.2	0.3	-0.4	0.5	0.5	-0.5
Short access total locomotion	1.1	1.1	1.3	-1.1	-1.0	-1.1	1.1
Compulsive drug intake	2.9	2.9	3.4	1.3	1.7	1.9	-1.9
One hour access (0.3 mA shock)	2.6	3.0	4.0	-2.0	-1.2	-1.8	1.8
One hour access (shock baseline)	6.6	7.6	8.0	-2.8	-2.5	-2.8	2.8
Number of responses in last shaping day	0.1	0.1	0.1	0.3	0.3	0.4	-0.4
Context. condit. distance diff. score	4.5	5.4	6.5	-2.5	-2.5	-2.1	2.1
Locomotion velocity, session 1	0.1	0.1	0.3	-0.2	-0.5	-0.2	0.2
Locomotion distance, session 1	0.2	0.2	0.9	-0.1	-1.0	-0.1	0.1
Locomotion velocity, session 2	0.1	0.1	0.1	-0.4	0.3	-0.3	0.3
Locomotion distance, session 2	0.0	0.0	0.1	-0.0	-0.1	-0.3	0.3
Locomotion velocity, session 3	0.1	0.1	0.4	-0.1	-0.6	0.0	-0.0
Locomotion distance, session 3	0.4	0.5	0.8	0.9	-0.0	0.7	-0.7
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	0.2	0.7	0.3	-0.3
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.1	0.3	-0.0	0.0
Locomotion velocity, session 7	0.3	0.3	0.8	-0.5	-0.9	-0.4	0.4
Locomotion distance, session 7	0.0	0.0	0.0	0.0	0.1	0.0	-0.0
Stereotopy head waving bouts, day 7	0.2	0.2	0.2	0.5	-0.4	0.4	-0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.1	-0.5	0.1	-0.1
Locomotion velocity, session 8	2.5	3.0	4.9	-1.8	-2.2	-1.4	1.4
Locomotion distance, session 8	3.5	5.2	7.4	-2.2	-2.7	-2.0	2.0
Degree of sensitization distance	0.4	0.4	0.9	-0.9	-0.1	-0.7	0.7
Degree of sensitization stereotypy	0.3	0.3	1.1	0.0	-1.1	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	-0.7	-0.1	-0.6	0.6
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.5	-1.4	-1.6	-1.3	1.3
Condit. Reinf. active responses	0.1	0.1	0.5	-0.2	0.7	-0.2	0.2
Condit. Reinf. inactive responses	0.6	0.7	1.8	0.7	1.4	0.5	-0.5
Incentive salience index mean	0.1	0.1	0.3	0.0	0.6	0.1	-0.1
Condit. Reinf. lever presses	0.4	0.6	1.2	0.6	1.1	0.6	-0.6
Time in familiar zone, hab. session 1	3.3	3.1	4.1	1.9	1.0	2.0	-2.0
Time in novel zone, hab. session 1	6.6	6.4	7.8	-2.5	-1.9	-2.8	2.8
Total zone transitions, hab. session 1	0.5	0.7	0.9	-0.9	-0.3	-1.0	1.0
Total locomotion distance, hab. session 1	0.3	0.4	0.6	0.4	0.8	0.7	-0.7
Locomotion velocity, hab. session 1	0.3	0.5	0.7	0.6	0.8	0.7	-0.7
Time in familiar zone, hab. session 2	1.1	1.2	1.4	0.9	1.2	1.1	-1.1
Time in novel zone, hab. session 2	2.5	2.5	4.0	-1.3	-2.0	-1.4	1.4
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.0	0.5	0.2	-0.2
Total locomotion distance, hab. session 2	1.7	2.2	2.7	1.2	1.6	1.5	-1.5
Locomotion velocity, hab. session 2	2.4	3.3	3.5	1.6	1.9	1.9	-1.9
Novel to familiar place preference ratio	0.3	0.3	1.1	-0.1	-1.0	-0.3	0.3
Novelty place preference	0.6	0.6	1.8	-0.3	-1.3	-0.5	0.5
Time in novel zone, NPP test	0.6	0.7	1.7	-0.4	-1.3	-0.6	0.6
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	0.3	-0.2	0.2
Total locomotion distance, NPP test	0.4	0.6	1.5	0.5	1.2	0.6	-0.6
Locomotion velocity, NPP test	0.5	0.8	1.6	0.7	1.2	0.7	-0.7
Pavlov. Cond. lever latency	2.2	2.8	3.1	-1.6	-1.5	-1.8	1.8
Pavlov. Cond. magazine entry latency	1.9	2.4	2.9	1.7	0.9	1.7	-1.7
Pavlov. Cond. change in total contacts	2.5	2.7	2.7	1.7	1.6	1.7	-1.7
Pavlov. Cond. index score	2.7	3.5	4.1	1.9	1.4	2.0	-2.0
Pavlov. Cond. latency score	2.0	2.5	3.0	1.7	1.1	1.7	-1.7
Pavlov. Cond. lever contacts	1.3	1.5	1.8	1.3	0.9	1.4	-1.4
Pavlov. Cond. magazine entry number	3.4	4.3	5.0	-2.2	-1.6	-2.2	2.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.0	-0.0	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.3	4.8	2.1	1.7	2.2	-2.2
Pavlov. Cond. response bias	2.1	2.6	2.9	1.6	1.3	1.7	-1.7
Bone: apparent density	0.2	0.3	0.9	-0.3	-1.0	-0.3	0.3
Bone surface	0.5	0.8	1.1	1.1	-0.0	1.0	-1.0
Bone volume	0.1	0.2	0.2	0.4	-0.4	0.4	-0.4
Bone: connectivity density	0.1	0.1	0.2	-0.2	-0.5	-0.2	0.2
Bone: cortical apparent density	0.9	1.2	1.6	1.3	0.6	1.2	-1.2
Bone: cortical area	0.9	1.3	3.3	-0.7	-1.8	-0.9	0.9
Bone: cortical porosity	0.4	0.4	0.6	0.6	-0.4	0.7	-0.7
Bone: cortical porosity	0.4	0.4	0.6	0.7	-0.4	0.8	-0.8
Bone: cortical thickness	0.9	1.4	2.3	-0.9	-1.5	-1.1	1.1
Bone: cortical thickness	0.1	0.1	0.3	-0.1	-0.6	-0.3	0.3
Bone: cortical tissue density	1.0	1.2	1.7	1.3	0.6	1.2	-1.2
Bone: elastic displacement	2.0	2.3	2.3	-1.5	-1.5	-1.5	1.5
Bone: elastic work	3.5	4.6	7.4	-1.9	-2.7	-1.9	1.9
Bone: endosteal estimation	0.2	0.4	1.5	0.0	-1.2	0.0	-0.0
Bone: endosteal perimeter	0.1	0.1	0.2	0.4	-0.3	0.4	-0.4
Bone: final force	0.4	0.7	1.3	-0.6	-1.1	-0.8	0.8
Bone: final moment	0.6	1.0	2.0	-0.7	-1.4	-0.9	0.9
Bone: marrow area	0.2	0.4	1.6	0.0	-1.3	-0.0	0.0
Bone: maximum diameter	0.2	0.4	1.5	-0.2	-1.2	-0.4	0.4
Bone: maximum force	0.8	1.4	3.8	-0.7	-1.9	-0.8	0.8
Bone: maximum moment	1.0	1.8	4.8	-0.9	-2.2	-0.9	0.9
Bone: minimum diameter	0.3	0.5	1.9	-0.1	-1.4	-0.2	0.2
Bone: periosteal estimation	0.8	1.5	4.8	-0.6	-2.2	-0.7	0.7
Bone: periosteal perimeter	0.1	0.2	0.7	0.2	-0.8	0.1	-0.1
Bone: post-yield work	0.1	0.1	0.3	-0.6	-0.1	-0.3	0.3
Bone: stiffness	0.1	0.2	0.4	0.6	-0.2	0.5	-0.5
Bone: tissue strength	7.1	6.9	7.8	-2.8	-2.1	-2.7	2.7
Bone: trabecular number	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1
Bone: trabecular spacing	0.2	0.3	1.0	0.0	1.0	0.1	-0.1
Bone: trabecular thickness	2.0	2.4	5.0	-1.2	-2.2	-1.3	1.3
Bone: trabecular tissue density	0.3	0.4	0.9	-0.4	-0.9	-0.4	0.4
Breakpoint value in progressive ratio session	0.5	0.6	1.1	0.6	1.0	0.7	-0.7
Distance traveled before self-admin	2.7	2.9	3.0	-1.6	-1.7	-1.7	1.7
Distance traveled after self-admin	0.5	0.6	1.2	-1.1	-0.7	-0.6	0.6
Delta time in closed arm before/after self-admin	0.6	0.6	1.9	-0.4	-1.4	-0.4	0.4
Delta time in open arm before/after self-admin	0.3	0.3	1.1	1.1	0.3	0.0	-0.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	0.7	0.3	0.0	-0.0
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.4	-0.2	-0.1	0.1
Active lever presses in extinction session 6	0.6	0.6	0.9	-0.4	-0.5	-1.0	1.0
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.2	0.2
Time in closed arm before self-admin	0.2	0.3	0.7	0.4	0.8	0.4	-0.4
Time in closed arm after self-admin	0.1	0.1	0.2	-0.3	-0.3	-0.4	0.4
Time in open arm before self-admin	0.3	0.3	0.5	-0.7	-0.6	-0.3	0.3
Time in open arm after self-admin	0.6	0.6	2.0	1.4	0.3	0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.4	-0.2	-0.3	0.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.6	0.2	-0.5	0.5
Time to tail flick, vehicle, after self-admin	0.8	0.8	0.8	0.9	0.9	0.9	-0.9
Time to tail flick, test, before self-admin	1.0	1.0	1.3	-1.0	-1.1	-0.9	0.9
Time to tail flick, test, after self-admin	1.1	1.1	2.5	-1.0	-1.6	-0.7	0.7
Delta time to tail flick, vehicle, before/after SA	1.8	1.8	2.8	1.7	0.5	1.4	-1.4
Delta time to tail flick, test, before/after SA	0.3	0.3	0.9	-0.1	-0.9	-0.3	0.3
Ambulatory time before self-admin	3.8	4.0	4.4	-2.0	-1.7	-2.1	2.1
Ambulatory time after self-admin	1.1	1.2	2.0	-1.4	-0.9	-1.0	1.0
Total heroin consumption	0.3	0.3	0.7	-0.7	-0.8	-0.2	0.2
Area under the delay curve	1.4	1.5	2.3	-1.0	-0.7	-1.5	1.5
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	-0.4	-0.3	-0.6	0.6
Delay disc. indifference point, 16s delay	1.4	1.4	1.7	-1.2	-0.9	-1.3	1.3
Delay disc. indifference point, 2s delay	1.1	1.2	1.8	-0.8	-0.8	-1.3	1.3
Delay disc. indifference point, 24s delay	0.7	0.7	0.9	-0.9	0.0	-0.9	0.9
Delay disc. indifference point, 4s delay	0.8	0.9	1.4	-0.7	-0.4	-1.2	1.2
Delay disc. indifference point, 8s delay	0.7	0.7	1.2	-0.6	-0.5	-1.1	1.1
Delay discount exponential model param	1.8	1.9	2.8	1.1	0.8	1.7	-1.7
Delay discount hyperbolic model param	1.6	1.7	2.6	1.0	0.7	1.6	-1.6
Fecal boli incidents, locomotor time 1	0.2	0.2	0.2	-0.5	0.4	-0.4	0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.8	-0.1	-0.9	0.1	-0.1
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.6	1.3	1.0	0.9	-0.9
Bouts of movement, locomotor time 1	0.2	0.2	0.3	0.5	0.4	0.5	-0.5
Total resting periods, locomotor time 1	0.4	0.4	0.5	0.7	0.5	0.6	-0.6
Rest time, locomotor task time 1	0.3	0.3	0.3	0.4	0.6	0.6	-0.6
Distance moved, locomotor task time 1	1.0	1.0	1.3	-0.9	-1.1	-1.0	1.0
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.1	0.2	0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.7	0.3	0.8	0.2	-0.2
Bouts of movement, locomotor time 2	0.4	0.4	1.1	0.3	1.0	0.5	-0.5
Total resting periods, locomotor time 2	0.4	0.5	1.1	0.3	1.0	0.6	-0.6
Rest time, locomotor task time 2	0.2	0.2	0.3	0.2	0.5	0.4	-0.4
Distance moved, locomotor task time 2	0.4	0.4	1.2	-0.3	-1.1	-0.5	0.5
Vertical activity count, locomotor time 2	2.0	2.2	2.7	1.7	0.9	1.6	-1.6
Weight adjusted by age	0.4	0.5	1.4	-1.2	-0.5	-0.3	0.3
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.2	0.9	-0.0	1.1	-1.1
Locomotion in novel chamber	2.2	2.7	4.5	1.3	2.1	1.5	-1.5
Locomotion in novel chamber post-restriction	0.3	0.3	0.6	-0.7	-0.0	-0.6	0.6
Progressive ratio	3.4	4.0	5.0	1.5	2.2	2.1	-2.1
Food seeking constrained by brief footshock	1.2	1.4	2.2	-1.3	-1.5	-1.0	1.0
Seeking ratio, punishment vs. effort	4.1	5.0	6.8	-1.9	-2.6	-2.2	2.2
Run reversals in cocaine runway, females	2.0	2.0	2.5	1.4	1.6	1.3	-1.3
Run reversals in cocaine runway, males	2.2	2.1	2.3	-1.4	-1.4	-1.5	1.5
Latency to leave start box in cocaine runway	7.9	8.7	10.1	3.0	2.3	3.2	-3.2
Latency to leave start box in cocaine runway, F	3.4	3.8	4.1	2.0	1.7	2.0	-2.0
Latency to leave start box in cocaine runway, M	3.6	3.4	4.5	1.7	1.4	2.1	-2.1
Cd content in liver	3.8	4.1	4.6	-2.1	-1.8	-2.1	2.1
Co content in liver	0.1	0.1	0.1	-0.3	-0.4	-0.4	0.4
Cu content in liver	0.5	0.6	2.1	0.2	-1.4	-0.2	0.2
Fe content in liver	1.1	1.3	1.7	-1.1	-1.3	-1.1	1.1
K content in liver	0.4	0.4	1.3	0.2	1.1	-0.3	0.3
Mg content in liver	0.3	0.3	0.8	0.4	0.9	-0.2	0.2
Mn content in liver	0.1	0.1	0.2	0.5	0.4	0.2	-0.2
Na content in liver	0.0	0.0	0.1	-0.1	-0.2	-0.2	0.2
Rb content in liver	0.9	1.2	2.0	-0.9	-0.1	-1.4	1.4
Se content in liver	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.1
Sr content in liver	0.1	0.1	0.1	-0.3	0.0	-0.3	0.3
Zn content in liver	0.4	0.5	0.8	-0.5	0.2	-0.9	0.9