Clip4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000008806	0.36	0.15	0.0e+00	0.38	0.37	0.37	0.37	1.2e-44	1.1e-43	1.8e-43	5.1e-43
2	Adipose	mRNA stability	ENSRNOG00000008806	0.03	0.03	9.7e-04	0.02	0.01	0.02	0.02	2.2e-03	7.8e-03	1.8e-03	5.4e-03
3	BLA	gene expression	ENSRNOG00000008806	0.19	0.12	2.8e-08	0.14	0.14	0.14	0.14	7.7e-08	5.8e-08	6.0e-08	5.1e-08
4	Brain	gene expression	ENSRNOG00000008806	0.15	0.08	0.0e+00	0.14	0.16	0.16	0.15	4.4e-13	1.0e-14	1.3e-14	3.6e-14
5	PL	gene expression	ENSRNOG00000008806	0.08	0.06	7.8e-06	0.05	0.07	0.06	0.06	6.6e-05	3.8e-06	2.6e-05	1.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.3	1.1	1.7	-1.1	1.1	-1.3	-0.9	-0.9
BMI without tail	0.1	0.2	0.3	-0.6	0.2	-0.2	-0.4	-0.5
Body weight	1.5	6.4	7.2	-2.6	2.4	-2.3	-2.6	-2.7
Epididymis fat weight	14.5	33.9	36.4	-5.9	5.7	-5.5	-6.0	-6.0
Glucose	0.4	0.7	0.8	-0.9	0.6	-0.7	-0.9	-0.9
Heart weight	9.8	14.0	14.5	-3.8	3.7	-3.6	-3.8	-3.8
Left kidney weight	0.0	0.1	0.5	0.7	0.1	-0.2	0.2	0.3
Right kidney weight	0.6	1.7	2.3	-0.9	1.5	-1.5	-1.3	-1.2
Tail length	0.1	0.4	0.7	-0.6	0.5	-0.2	-0.8	-0.8
Length with tail	1.2	4.5	5.9	-2.2	1.8	-1.7	-2.4	-2.4
Length without tail	0.8	1.8	2.2	-1.5	1.3	-1.0	-1.5	-1.5
Liver weight, left	2.0	3.2	3.7	-1.6	1.8	-1.7	-1.9	-1.9
Liver weight, right	9.2	15.3	16.8	-3.8	3.9	-3.6	-4.1	-4.1
Parametrial fat weight	5.2	10.2	11.9	-3.4	3.1	-2.9	-3.2	-3.3
Retroperitoneal fat weight	21.1	69.7	73.3	-8.5	8.3	-7.9	-8.5	-8.6
Intraocular pressure	2.7	3.8	4.7	-2.2	1.7	-1.7	-2.0	-2.1
Extensor digitorum longus weight	4.8	19.1	20.2	4.2	-4.5	4.3	4.5	4.4
Soleus weight	5.6	16.3	17.2	3.9	-4.0	4.1	4.1	4.1
Tibialis anterior weight	4.0	13.8	15.0	3.5	-3.7	3.8	3.9	3.8
Tibia length	2.4	6.8	8.3	-2.9	2.2	-2.3	-2.8	-2.8
Number of licking bursts	0.3	0.4	0.7	0.5	-0.9	0.6	0.5	0.5
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.4	-0.2	-0.0	0.5	0.5
Times rat made contact with spout	3.4	3.9	6.3	1.7	-2.1	2.5	1.7	1.6
Mean time between licks in bursts	2.7	3.7	4.9	-1.7	2.2	-1.8	-2.0	-1.9
Mean num. licks in bursts	0.2	0.2	0.5	0.3	-0.3	0.7	0.4	0.3
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.3	-0.0	-0.2	-0.2	-0.2
Water consumed over 24 hours	1.2	1.4	1.7	1.3	-1.1	1.3	1.1	1.1
Indifference point 0 sec	0.2	0.3	0.5	-0.7	0.2	0.3	-0.6	-0.7
Indifference point AUC	1.3	1.6	2.3	0.9	-1.5	1.1	1.3	1.3
Indifference point function ln k	0.1	0.1	0.2	0.1	0.5	-0.3	-0.2	-0.1
Indifference point function log k	0.1	0.1	0.2	0.1	0.5	-0.3	-0.2	-0.1
Delay discounting total patch changes 0 sec	0.1	0.2	0.3	-0.6	0.2	0.4	-0.4	-0.5
Delay discounting total patch changes 12 sec	0.6	0.8	1.2	-1.1	0.8	-0.7	-0.9	-1.0
Delay discounting total patch changes 18 sec	0.1	0.1	0.3	-0.4	-0.4	0.6	0.0	-0.1
Delay discounting total patch changes 24 sec	1.2	1.5	1.9	-1.3	1.1	-0.9	-1.3	-1.4
Delay discounting total patch changes 6 sec	0.1	0.1	0.3	-0.5	-0.3	0.5	-0.0	-0.1
Delay discounting time to switch 0 sec	0.1	0.2	0.3	0.5	-0.2	0.4	0.4	0.4
Delay discounting water rate 0 sec	0.0	0.1	0.1	-0.3	0.0	-0.3	-0.3	-0.3
Delay discounting water rate 12 sec	2.2	3.3	4.9	-1.3	2.1	-2.2	-1.7	-1.6
Delay discounting water rate 18 sec	0.6	0.8	1.7	-0.4	1.0	-1.3	-0.7	-0.6
Delay discounting water rate 24 sec	2.4	3.3	4.8	-1.8	1.8	-2.2	-1.7	-1.6
Delay discounting water rate 6 sec	1.6	2.3	3.2	-1.2	1.8	-1.6	-1.5	-1.4
Locomotor activity	0.1	0.1	0.2	-0.0	-0.5	0.5	0.3	0.2
Locomotor testing distance	0.8	1.3	1.8	0.9	-1.3	1.3	1.2	1.1
Locomotor testing rearing	0.6	1.0	1.5	0.7	-1.2	0.7	1.1	1.1
Light reinforcement 1	3.9	7.2	8.0	2.5	-2.6	2.7	2.8	2.8
Light reinforcement 2	3.2	4.2	5.5	2.0	-1.9	2.4	2.0	2.0
Reaction time number correct	0.6	0.8	1.4	1.2	-0.8	0.1	1.0	1.1
Reaction time mean minus median	0.1	0.1	0.2	0.1	-0.4	0.2	0.3	0.3
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.1	0.1
Reaction time num false alarms	0.4	0.6	1.1	0.7	-0.8	1.0	0.7	0.6
Reaction time num false alarms AUC	0.8	1.1	1.5	1.0	-1.0	1.2	1.0	0.9
Reaction time trials correct on left	0.6	0.8	1.4	1.2	-0.8	0.1	1.0	1.1
Reaction time trials on left	0.6	0.9	1.5	1.2	-0.9	0.2	1.0	1.1
Reaction time mean	0.4	0.5	1.3	-1.2	0.1	-0.1	-0.8	-0.9
Reaction time mean AUC	0.3	0.4	1.1	-1.0	0.0	-0.0	-0.6	-0.7
Median of all reaction times	0.4	0.6	1.5	-1.2	0.1	-0.0	-0.8	-0.9
Reaction time omissions	0.1	0.2	0.3	0.4	-0.4	0.5	0.5	0.4
Reaction time false alarm rate	0.2	0.2	0.9	0.1	-0.4	1.0	0.2	0.2
Reaction time premature initiation rate	0.2	0.2	0.3	-0.4	0.6	-0.1	-0.5	-0.5
Reaction time premature initiations	0.0	0.0	0.1	0.3	0.1	-0.1	0.1	0.1
Std. dev. reaction times	0.1	0.2	0.4	-0.7	0.1	-0.2	-0.4	-0.5
Reaction time trials completed	0.6	0.9	1.5	1.2	-0.9	0.2	1.0	1.1
Reaction time trials AUC	0.8	1.2	2.0	1.4	-1.0	0.3	1.2	1.2
Social response proportion	0.3	0.4	0.8	-0.9	0.4	-0.4	-0.5	-0.6
Social responses	0.0	0.1	0.2	-0.5	-0.2	0.1	-0.0	-0.1
Social time	0.5	0.7	1.2	-1.1	0.7	-0.5	-0.8	-0.9
Conditioned locomotion	2.5	3.0	4.9	2.2	-1.3	1.3	1.8	1.9
Cocaine response after cond. corrected	2.5	2.8	3.9	1.5	-2.0	1.4	1.7	1.7
Cocaine response after cond. not corrected	3.3	3.7	4.2	2.0	-1.9	1.5	2.0	2.0
Cocaine response before conditioning	0.4	0.5	0.9	1.0	-0.2	0.7	0.8	0.8
Saline control response	1.2	1.6	3.2	0.8	-1.3	1.8	1.1	1.0
Condit. Reinf. active minus inactive responses	3.0	3.7	5.3	2.3	-1.7	1.0	2.1	2.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.2	1.1	-0.5	0.3	0.8	0.9
Condit. Reinf. active responses	2.2	3.1	4.7	2.2	-1.5	0.7	2.0	2.1
Condit. Reinf. inactive responses	1.5	1.9	2.6	1.6	-1.2	0.7	1.5	1.6
Condit. Reinf. lever presses	1.4	1.9	2.8	1.7	-1.2	0.6	1.5	1.6
Condit. Reinf. lever reinforcers received	1.9	2.7	3.9	2.0	-1.5	0.5	1.8	2.0
Pavlov. Cond. lever latency	1.3	1.8	2.1	-1.4	1.3	-1.2	-1.4	-1.5
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	0.4	-0.4	0.3	0.4	0.4
Pavlov. Cond. change in total contacts	0.4	0.6	0.9	0.9	-0.7	0.4	0.8	0.9
Pavlov. Cond. index score	0.6	0.7	1.1	1.0	-0.8	0.5	0.9	1.0
Pavlov. Cond. latency score	0.5	0.6	0.9	0.9	-0.8	0.5	0.8	0.9
Pavlov. Cond. lever contacts	0.6	0.8	1.1	1.0	-0.8	0.6	0.9	1.0
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.2	0.2	-0.2	-0.2	-0.3
Pavlov. Cond. intertrial magazine entries	2.8	3.6	4.1	-1.8	2.0	-2.0	-1.8	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	0.8	-0.5	0.2	0.7	0.7
Pavlov. Cond. response bias	1.2	1.7	2.2	1.5	-1.1	1.0	1.4	1.4
Conditioned reinforcement - actives	0.4	0.4	0.9	0.5	-0.9	0.6	0.5	0.5
Conditioned reinforcement - inactives	2.2	2.5	3.4	1.4	-1.8	1.8	1.4	1.4
Conditioned locomotion	0.0	0.1	0.1	-0.2	-0.2	0.1	-0.3	-0.3
Intermittent access intake day 1-15 change	0.3	0.3	1.2	0.1	0.6	-1.1	-0.2	-0.1
Intermittent access intake escalation	0.6	0.6	1.7	-0.2	0.8	-1.3	-0.5	-0.3
Intermittent access intake escalation 2	1.2	1.2	2.8	-0.7	1.2	-1.7	-0.9	-0.8
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	-0.2	-0.4	0.5	-0.1	-0.1
Intermitt. access day 15 inactive lever presses	4.2	4.7	5.9	1.9	-2.2	2.4	2.1	2.1
Intermitt. access escalation Index	0.4	0.4	1.1	-1.1	0.2	-0.1	-0.6	-0.7
Intermittent access day 1 total infusions	5.3	6.0	8.5	1.9	-2.9	2.8	2.3	2.2
Intermittent access day 15 total infusions	1.5	1.7	2.3	1.2	-1.5	1.2	1.3	1.3
Intermittent access terminal intake (last 3 days)	1.6	1.8	2.7	1.2	-1.6	1.2	1.3	1.3
Intermittent access total infusions	2.0	2.2	3.3	1.3	-1.8	1.5	1.4	1.4
Intermittent access day 1 locomotion	2.9	2.9	3.7	1.4	-1.9	1.9	1.7	1.6
Intermittent access day 15 total locomotion	0.5	0.6	1.1	0.7	-1.1	0.6	0.6	0.6
Intermittent access total locomotion	0.3	0.4	0.9	0.4	-1.0	0.7	0.5	0.4
Intermittent access standard deviation	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.1	-0.1
Cocaine induced anxiety	0.1	0.1	0.2	0.2	0.1	0.4	0.2	0.2
Post-drug Anxiety	0.5	0.6	0.8	-0.8	0.8	-0.1	-0.9	-0.9
Baseline Anxiety	0.3	0.3	0.5	-0.6	0.4	-0.4	-0.7	-0.7
Lifetime Intake	2.3	2.6	3.8	1.2	-2.0	1.8	1.5	1.4
Incentive Sensitization - Responses	0.1	0.1	0.4	0.1	0.2	-0.6	-0.2	-0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.1	0.3	-0.7	-0.4	-0.3
Progressive ratio test 1 active lever presses	0.5	0.5	1.0	0.4	-1.0	0.9	0.6	0.6
Progressive ratio test 1 breakpoint	0.5	0.5	1.0	0.4	-1.0	0.8	0.5	0.5
Progressive ratio test 1 inactive lever presses	1.1	1.2	2.2	0.6	-1.5	1.2	1.0	1.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.2	0.0	-0.4	0.2	-0.0	-0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.1	-0.5	0.3	0.0	0.0
Progressive ratio test 2 inactive lever presses	0.7	0.9	1.6	0.7	-1.3	0.9	0.8	0.8
Total sessions with >9 infusions	0.6	0.7	1.1	0.5	-1.1	0.9	0.8	0.8
Short access day 1 total inactive lever presses	3.3	3.6	5.0	1.4	-2.2	2.1	1.9	1.8
Short access day 10 total inactive lever presses	0.3	0.3	0.5	0.5	-0.7	0.5	0.6	0.5
Short access day 1 total infusions	2.0	2.1	3.8	0.7	-1.9	1.7	1.4	1.3
Short access day 10 total infusions	3.7	4.1	5.5	1.7	-2.3	2.2	1.9	1.9
Short access total infusions	1.5	1.6	2.7	0.7	-1.6	1.6	1.1	1.0
Short access day 1 locomotion	4.2	4.4	5.0	1.9	-2.2	2.1	2.2	2.1
Short access day 10 total locomotion	1.3	1.4	1.9	1.1	-1.3	1.4	1.1	1.0
Short access total locomotion	0.4	0.5	0.9	0.3	-0.9	0.9	0.5	0.5
Compulsive drug intake	0.4	0.4	0.7	-0.5	0.8	-0.7	-0.5	-0.5
One hour access (0.3 mA shock)	1.4	1.7	2.4	1.2	-1.5	1.5	1.1	1.1
One hour access (shock baseline)	1.8	2.0	3.2	1.2	-1.8	1.6	1.2	1.2
Number of responses in last shaping day	0.0	0.0	0.0	0.2	-0.2	0.2	0.1	0.1
Context. condit. distance diff. score	0.2	0.2	0.4	-0.2	0.5	-0.7	-0.4	-0.4
Locomotion velocity, session 1	0.1	0.1	0.2	-0.4	0.1	-0.2	-0.2	-0.3
Locomotion distance, session 1	1.9	2.5	2.8	1.5	-1.5	1.5	1.7	1.7
Locomotion velocity, session 2	0.1	0.1	0.2	-0.4	0.3	0.2	-0.4	-0.5
Locomotion distance, session 2	0.0	0.1	0.2	-0.1	-0.2	0.5	0.1	-0.0
Locomotion velocity, session 3	0.5	0.6	1.5	0.7	-0.7	1.2	0.6	0.6
Locomotion distance, session 3	1.4	1.6	3.0	0.9	-1.4	1.7	1.1	1.0
Stereotopy head waving bouts, day 3	1.2	1.4	1.7	1.3	-1.3	1.2	1.0	1.1
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.3	-0.1	0.2	0.0	0.1
Locomotion velocity, session 7	0.7	0.8	1.7	0.8	-0.7	1.3	0.7	0.7
Locomotion distance, session 7	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.3	-0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.2	0.0	0.0	0.4	0.1	0.0
Stereotopy head waving duration, day 7	0.7	0.9	1.8	0.7	-0.8	1.3	0.8	0.8
Locomotion velocity, session 8	0.1	0.1	0.3	-0.0	-0.3	0.5	-0.0	-0.1
Locomotion distance, session 8	0.1	0.1	0.3	0.5	-0.1	0.3	0.3	0.4
Degree of sensitization distance	1.7	1.8	2.7	-1.1	1.4	-1.7	-1.2	-1.2
Degree of sensitization stereotypy	0.0	0.0	0.2	-0.2	0.1	0.4	-0.0	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	0.3	-0.2	-0.6	-0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.6	0.2	0.3	-0.5	-0.6
Condit. Reinf. active responses	0.5	0.6	0.9	0.7	-0.9	0.8	0.8	0.8
Condit. Reinf. inactive responses	1.6	1.8	2.4	1.5	-1.4	0.6	1.5	1.6
Incentive salience index mean	0.4	0.4	1.2	0.4	-0.7	1.1	0.4	0.4
Condit. Reinf. lever presses	1.6	2.1	4.7	1.1	-1.4	2.2	1.2	1.2
Time in familiar zone, hab. session 1	0.6	0.6	0.9	-1.0	0.6	-0.3	-0.8	-0.9
Time in novel zone, hab. session 1	0.8	0.8	1.3	-0.8	0.8	-1.1	-0.8	-0.7
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.4	-0.0	-0.0	0.4	0.4
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.3	0.3	-0.2	0.2	0.2
Locomotion velocity, hab. session 1	0.6	0.8	1.4	1.2	-0.5	0.5	1.0	1.1
Time in familiar zone, hab. session 2	0.1	0.1	0.6	-0.1	-0.1	0.8	-0.0	-0.1
Time in novel zone, hab. session 2	0.6	0.6	1.5	-0.6	0.6	-1.2	-0.6	-0.6
Total zone transitions, hab. session 2	0.2	0.2	0.4	0.5	-0.1	0.7	0.4	0.4
Total locomotion distance, hab. session 2	0.1	0.2	0.4	0.6	0.0	0.5	0.4	0.4
Locomotion velocity, hab. session 2	0.3	0.5	0.8	0.9	-0.3	0.8	0.7	0.7
Novel to familiar place preference ratio	1.2	1.2	3.3	-0.7	1.2	-1.8	-0.7	-0.6
Novelty place preference	1.7	1.8	4.0	-1.0	1.5	-2.0	-1.0	-0.9
Time in novel zone, NPP test	1.9	2.0	4.0	-1.1	1.6	-2.0	-1.1	-1.0
Total zone transitions, NPP test	1.5	2.1	2.7	1.5	-1.2	1.6	1.4	1.4
Total locomotion distance, NPP test	1.3	1.9	2.8	1.7	-1.0	1.0	1.5	1.5
Locomotion velocity, NPP test	2.8	4.0	5.2	2.3	-1.6	1.8	2.1	2.2
Pavlov. Cond. lever latency	2.3	3.0	6.0	-1.4	1.8	-2.5	-1.4	-1.3
Pavlov. Cond. magazine entry latency	0.1	0.2	0.8	0.2	-0.3	0.9	0.1	0.0
Pavlov. Cond. change in total contacts	0.3	0.3	1.2	0.2	-0.5	1.1	0.1	0.0
Pavlov. Cond. index score	1.0	1.3	3.0	0.9	-1.1	1.7	0.8	0.8
Pavlov. Cond. latency score	0.9	1.2	2.8	0.9	-1.0	1.7	0.8	0.7
Pavlov. Cond. lever contacts	1.5	1.8	4.1	1.1	-1.3	2.0	1.1	1.0
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	-0.7	0.5	-1.0	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.3	1.2	-1.5	1.0	1.4	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	4.5	1.4	-1.5	2.1	1.3	1.3
Pavlov. Cond. response bias	1.5	1.9	3.5	1.3	-1.2	1.9	1.2	1.1
Bone: apparent density	5.5	9.2	10.9	2.8	-3.3	2.9	3.1	3.0
Bone surface	2.1	3.8	4.3	1.9	-2.1	2.0	1.9	1.9
Bone volume	2.8	4.7	6.0	2.0	-2.5	2.2	2.1	2.1
Bone: connectivity density	5.3	8.4	10.1	2.7	-3.2	2.7	3.0	2.9
Bone: cortical apparent density	0.5	0.7	1.2	0.8	-1.1	0.4	0.8	0.9
Bone: cortical area	0.3	0.4	0.6	0.6	-0.5	0.5	0.8	0.8
Bone: cortical porosity	1.0	1.1	1.2	1.1	-1.0	0.9	1.1	1.1
Bone: cortical porosity	0.9	1.0	1.1	1.0	-1.0	0.9	1.1	1.0
Bone: cortical thickness	0.0	0.1	0.3	-0.2	0.2	-0.6	0.1	0.1
Bone: cortical thickness	1.1	1.3	1.9	1.3	-1.0	0.5	1.3	1.4
Bone: cortical tissue density	0.4	0.5	0.9	0.6	-0.9	0.3	0.7	0.7
Bone: elastic displacement	0.6	0.7	1.2	1.0	-0.6	-0.1	1.0	1.1
Bone: elastic work	0.8	1.1	1.6	1.1	-0.9	0.5	1.2	1.3
Bone: endosteal estimation	0.2	0.4	0.9	0.8	-0.4	0.9	0.5	0.5
Bone: endosteal perimeter	0.1	0.2	0.5	0.4	-0.3	0.7	0.3	0.3
Bone: final force	0.1	0.2	0.3	0.3	-0.5	0.6	0.4	0.4
Bone: final moment	0.1	0.2	0.3	0.3	-0.4	0.6	0.4	0.4
Bone: marrow area	0.2	0.5	1.0	0.9	-0.5	1.0	0.5	0.6
Bone: maximum diameter	0.9	1.7	2.0	1.3	-1.1	1.4	1.3	1.3
Bone: maximum force	0.0	0.0	0.0	-0.0	-0.0	0.1	0.1	0.1
Bone: maximum moment	0.0	0.0	0.0	0.1	-0.0	0.1	0.1	0.1
Bone: minimum diameter	0.1	0.2	0.2	-0.5	0.4	0.4	-0.4	-0.5
Bone: periosteal estimation	0.4	0.9	1.1	1.0	-0.7	1.1	0.9	0.9
Bone: periosteal perimeter	0.1	0.2	0.3	0.5	-0.2	0.5	0.5	0.5
Bone: post-yield work	0.4	0.6	0.8	0.7	-0.8	0.9	0.7	0.7
Bone: stiffness	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.3	-0.3
Bone: tissue strength	0.3	0.3	0.5	-0.7	0.3	-0.2	-0.6	-0.6
Bone: trabecular number	4.7	7.3	9.4	2.4	-3.1	2.6	2.7	2.7
Bone: trabecular spacing	1.8	2.3	2.8	-1.7	1.5	-1.0	-1.6	-1.7
Bone: trabecular thickness	0.5	0.6	0.7	0.8	-0.7	0.8	0.8	0.8
Bone: trabecular tissue density	0.1	0.1	0.2	0.5	-0.4	0.2	0.2	0.2
Breakpoint value in progressive ratio session	0.6	0.7	1.0	0.7	-0.8	1.0	0.9	0.8
Distance traveled before self-admin	0.1	0.1	0.2	0.4	0.0	0.1	0.2	0.2
Distance traveled after self-admin	0.2	0.2	0.4	-0.6	-0.0	-0.3	-0.4	-0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.3	0.2	-0.2	-0.3	-0.3
Delta time in open arm before/after self-admin	1.0	1.0	1.6	0.6	-1.3	1.1	1.0	0.9
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	0.2	-0.7	0.6	0.5	0.4
Extinction: sum of active levers before priming	0.8	0.9	1.0	0.9	-0.8	0.9	1.0	1.0
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.2	0.2	-0.3	-0.0	-0.0
Delta distance traveled before/after self-admin	1.3	1.4	2.3	-1.5	0.7	-1.0	-1.2	-1.3
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	-0.7	-0.0	-0.5	-0.5	-0.5
Time in closed arm before self-admin	0.5	0.6	1.4	-0.7	0.7	-1.2	-0.7	-0.6
Time in closed arm after self-admin	1.2	1.3	1.6	-1.2	1.0	-1.3	-1.1	-1.1
Time in open arm before self-admin	0.1	0.1	0.3	0.5	-0.1	0.5	0.2	0.2
Time in open arm after self-admin	2.9	3.2	4.5	1.6	-1.8	2.1	1.7	1.7
Sum of active levers in priming session hrs 5-6	1.2	1.2	1.4	1.2	-0.9	1.2	1.1	1.1
Time to tail flick, vehicle, before self-admin	1.5	1.6	1.7	-1.2	1.2	-1.3	-1.3	-1.3
Time to tail flick, vehicle, after self-admin	2.9	3.1	3.4	-1.8	1.8	-1.5	-1.8	-1.9
Time to tail flick, test, before self-admin	0.5	0.5	0.7	0.5	-0.7	0.8	0.8	0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.1	0.3	-0.2	-0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.2	0.4	-0.2	-0.3	-0.3
Delta time to tail flick, test, before/after SA	0.3	0.2	0.6	0.8	-0.4	0.3	0.4	0.4
Ambulatory time before self-admin	0.2	0.2	0.5	0.7	-0.2	0.4	0.5	0.5
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	-0.1	-0.4	-0.3	-0.3
Total heroin consumption	2.4	2.9	3.4	1.8	-1.5	1.7	1.8	1.8
Area under the delay curve	1.4	1.5	1.8	1.2	-1.3	1.3	1.2	1.2
Delay disc. indifference point, 0s delay	0.5	0.5	1.2	-0.5	0.8	-1.1	-0.6	-0.5
Delay disc. indifference point, 16s delay	1.9	1.9	2.7	1.2	-1.5	1.6	1.3	1.2
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1	-0.1
Delay disc. indifference point, 24s delay	5.4	5.3	5.8	2.4	-2.2	2.3	2.3	2.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.4	-0.6	0.5	0.4	0.4
Delay disc. indifference point, 8s delay	1.4	1.5	1.8	1.1	-1.3	1.4	1.2	1.1
Delay discount exponential model param	2.3	2.4	2.8	-1.5	1.7	-1.6	-1.5	-1.5
Delay discount hyperbolic model param	1.9	2.1	2.4	-1.4	1.6	-1.5	-1.4	-1.4
Fecal boli incidents, locomotor time 1	0.9	0.9	1.3	0.9	-1.1	1.1	0.8	0.8
Change in fecal boli incidents, locomotor task	4.5	4.3	6.0	-2.0	1.9	-2.4	-2.0	-2.0
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	0.4	-0.3	-0.7	0.3	0.4
Bouts of movement, locomotor time 1	4.6	5.1	6.2	2.5	-2.1	2.4	2.1	2.2
Total resting periods, locomotor time 1	4.3	4.8	6.1	2.5	-2.0	2.3	2.1	2.1
Rest time, locomotor task time 1	0.0	0.0	0.2	0.3	-0.1	0.4	0.0	0.0
Distance moved, locomotor task time 1	0.7	0.8	1.5	-1.2	0.7	-0.8	-0.8	-0.9
Vertical activity count, locomotor time 1	0.4	0.4	0.6	-0.6	0.7	-0.8	-0.6	-0.6
Time >=10cm from walls, locomotor time 2	0.2	0.3	1.3	0.0	-0.0	-1.1	0.0	0.1
Bouts of movement, locomotor time 2	0.2	0.2	0.6	0.1	0.5	-0.8	-0.3	-0.2
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.3	0.3	-0.5	-0.1	-0.0
Rest time, locomotor task time 2	1.9	2.2	2.8	1.6	-1.7	1.4	1.4	1.4
Distance moved, locomotor task time 2	1.2	1.4	1.9	-1.4	1.2	-1.1	-1.0	-1.1
Vertical activity count, locomotor time 2	1.5	1.7	2.2	-1.1	1.5	-1.5	-1.2	-1.2
Weight adjusted by age	0.2	0.2	0.4	-0.6	0.2	-0.2	-0.4	-0.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	-0.7	0.6	-0.6	-0.6	-0.6
Locomotion in novel chamber	1.3	1.6	1.8	-1.3	1.3	-1.2	-1.3	-1.3
Locomotion in novel chamber post-restriction	1.5	1.8	2.3	-1.5	1.2	-1.2	-1.4	-1.4
Progressive ratio	0.7	0.8	1.0	-0.9	0.9	-1.0	-0.9	-0.9
Food seeking constrained by brief footshock	2.5	3.1	4.1	1.7	-2.0	1.4	1.8	1.8
Seeking ratio, punishment vs. effort	1.8	2.2	2.7	1.5	-1.6	1.2	1.5	1.5
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.0	0.1
Run reversals in cocaine runway, males	0.5	0.5	0.7	0.7	-0.6	0.5	0.8	0.8
Latency to leave start box in cocaine runway	0.4	0.5	0.8	0.6	-0.9	0.6	0.7	0.6
Latency to leave start box in cocaine runway, F	0.7	0.7	1.0	0.7	-1.0	1.0	0.8	0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.4	-0.4	-0.3	0.2	0.3
Cd content in liver	0.1	0.1	0.1	0.2	-0.3	-0.3	0.3	0.3
Co content in liver	7.0	8.2	9.2	3.0	-2.8	2.6	3.0	3.0
Cu content in liver	0.5	0.6	1.3	0.4	-1.0	1.1	0.5	0.4
Fe content in liver	0.1	0.1	0.1	-0.4	-0.3	-0.1	-0.2	-0.2
K content in liver	0.4	0.4	0.5	-0.3	0.7	0.5	-0.7	-0.7
Mg content in liver	0.4	0.5	1.2	-0.4	0.2	1.1	-0.6	-0.7
Mn content in liver	0.2	0.2	0.4	0.6	-0.0	0.3	0.5	0.5
Na content in liver	0.3	0.4	1.3	0.4	-0.5	1.1	0.3	0.2
Rb content in liver	0.2	0.2	0.9	0.0	-0.2	0.9	-0.1	-0.2
Se content in liver	0.4	0.5	0.8	-0.9	0.4	-0.2	-0.8	-0.8
Sr content in liver	0.3	0.2	0.5	-0.1	0.7	-0.7	-0.4	-0.3
Zn content in liver	0.3	0.3	1.0	-1.0	0.1	0.1	-0.5	-0.6