Hub : Genes

Ap1b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000008786	0.29	0.12	0.0e+00	0.15	0.16	0.16	0.15	1.4e-16	1.6e-17	7.4e-17	1.3e-16
2	BLA	gene expression	ENSRNOG00000008786	0.24	0.12	1.2e-10	0.14	0.18	0.17	0.16	7.4e-08	6.3e-10	2.9e-09	1.1e-08
3	Brain	gene expression	ENSRNOG00000008786	0.05	0.04	9.8e-05	0.04	0.04	0.04	0.04	9.1e-05	1.6e-04	2.2e-04	3.0e-04
4	Brain	intron excision ratio	chr14:79928940:79929760	0.05	0.04	4.0e-03	0.03	0.03	0.03	0.03	9.0e-04	5.4e-04	1.1e-03	1.1e-03
5	IL	gene expression	ENSRNOG00000008786	0.26	0.16	5.2e-04	0.07	0.12	0.09	0.11	8.8e-03	8.0e-04	3.9e-03	1.1e-03
6	Liver	gene expression	ENSRNOG00000008786	0.12	0.08	7.0e-10	0.05	0.07	0.06	0.07	1.6e-06	2.2e-08	1.3e-07	2.3e-08
7	PL	gene expression	ENSRNOG00000008786	0.19	0.13	4.5e-09	0.1	0.12	0.13	0.12	6.4e-08	1.6e-09	8.2e-10	1.6e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	0.0	0.0	0.0	0.1	0.1	0.0	0.0	0.0	0.0	0.0
BMI without tail	0.4	0.9	1.5	-1.2	0.5	0.2	-1.2	1.0	0.9	1.2
Body weight	0.4	1.9	6.2	-0.6	-2.0	-2.5	0.1	-1.1	-1.1	-0.1
Epididymis fat weight	1.0	2.4	3.9	-1.5	1.3	1.0	-1.6	1.6	1.7	2.0
Glucose	27.0	41.2	51.2	5.4	-6.4	-5.6	6.6	-7.2	-7.1	-6.5
Heart weight	0.3	0.5	1.3	1.1	0.5	0.8	0.9	-0.3	-0.2	-0.4
Left kidney weight	0.3	0.9	2.2	-1.0	0.5	0.1	-1.1	0.9	0.9	1.5
Right kidney weight	1.5	4.2	5.6	-1.8	1.9	1.3	-2.3	2.3	2.2	2.4
Tail length	0.6	1.9	4.4	-2.1	-1.4	-2.0	-1.5	0.2	0.1	1.0
Length with tail	0.7	2.7	9.2	-0.9	-2.4	-3.0	-0.1	-1.2	-1.3	-0.3
Length without tail	1.2	2.7	3.8	0.9	-1.9	-1.9	1.3	-1.8	-1.8	-1.5
Liver weight, left	2.8	4.5	5.9	-1.8	2.0	1.5	-2.4	2.4	2.3	2.3
Liver weight, right	3.3	5.4	7.0	-1.6	2.5	2.2	-2.3	2.7	2.6	2.3
Parametrial fat weight	3.6	7.0	8.9	2.4	-2.5	-2.4	2.7	-2.9	-3.0	-2.6
Retroperitoneal fat weight	0.1	0.2	0.6	0.8	-0.0	0.1	0.6	-0.4	-0.4	-0.3
Intraocular pressure	0.9	1.3	1.8	1.2	-1.0	-0.8	1.3	-1.3	-1.2	-1.0
Extensor digitorum longus weight	1.1	4.5	12.9	-0.8	-3.2	-3.6	0.4	-1.9	-1.9	-0.5
Soleus weight	0.3	1.0	2.6	-1.3	-1.2	-1.6	-0.9	-0.1	-0.2	0.6
Tibialis anterior weight	0.6	2.2	4.6	0.3	-2.0	-2.1	0.9	-1.6	-1.6	-1.0
Tibia length	0.6	1.8	3.3	-1.7	0.7	0.3	-1.8	1.4	1.3	1.5
Number of licking bursts	1.0	1.2	3.7	-0.5	-1.7	-1.9	0.1	-0.9	-0.9	-0.1
Food consumed during 24 hour testing period	2.4	2.8	3.9	1.3	-1.8	-1.6	1.8	-2.0	-1.9	-1.3
Times rat made contact with spout	2.1	2.4	4.3	2.0	-0.8	-0.3	2.1	-1.6	-1.5	-1.7
Mean time between licks in bursts	2.6	3.6	4.7	2.2	-1.3	-1.3	2.1	-1.9	-2.0	-2.2
Mean num. licks in bursts	1.1	1.3	3.2	1.8	1.0	1.5	1.3	-0.3	-0.2	-1.1
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.5	-0.1	-0.1	0.4	-0.3	-0.3	-0.3
Water consumed over 24 hours	1.9	2.3	3.0	1.2	-1.5	-1.4	1.6	-1.7	-1.7	-1.3
Indifference point 0 sec	0.6	1.0	2.6	-0.4	-1.5	-1.6	0.2	-0.9	-0.9	-0.8
Indifference point AUC	0.2	0.2	0.3	0.4	-0.4	-0.5	0.5	-0.6	-0.5	-0.4
Indifference point function ln k	0.5	0.7	1.5	-1.0	0.4	0.3	-0.9	0.8	0.9	1.2
Indifference point function log k	0.5	0.7	1.5	-1.0	0.4	0.3	-0.9	0.8	0.9	1.2
Delay discounting total patch changes 0 sec	0.8	1.2	2.7	-0.2	-1.6	-1.7	0.4	-1.1	-1.1	-0.9
Delay discounting total patch changes 12 sec	0.5	0.7	1.4	0.0	-1.2	-1.2	0.3	-0.8	-0.8	-0.7
Delay discounting total patch changes 18 sec	2.9	3.8	4.7	1.6	-1.9	-1.7	1.9	-2.1	-2.1	-2.2
Delay discounting total patch changes 24 sec	0.6	0.7	1.8	1.1	0.6	1.0	0.7	-0.1	-0.2	-1.4
Delay discounting total patch changes 6 sec	0.8	1.3	2.5	0.2	-1.5	-1.6	0.7	-1.2	-1.2	-0.8
Delay discounting time to switch 0 sec	0.2	0.3	0.6	-0.1	0.7	0.8	-0.4	0.6	0.5	-0.0
Delay discounting water rate 0 sec	1.0	1.7	2.7	0.4	-1.6	-1.6	1.0	-1.4	-1.4	-1.0
Delay discounting water rate 12 sec	0.0	0.0	0.3	-0.2	-0.1	-0.1	0.0	-0.0	0.0	0.5
Delay discounting water rate 18 sec	1.6	2.1	3.6	-1.9	0.7	0.3	-1.9	1.5	1.4	1.8
Delay discounting water rate 24 sec	0.4	0.6	1.0	1.0	-0.4	-0.3	1.0	-0.8	-0.8	-0.7
Delay discounting water rate 6 sec	0.1	0.2	0.4	-0.6	-0.5	-0.6	-0.3	-0.1	-0.0	0.5
Locomotor activity	1.3	2.0	2.6	1.2	-1.4	-1.3	1.3	-1.5	-1.6	-1.5
Locomotor testing distance	0.3	0.5	1.4	-1.2	-0.2	-0.3	-1.1	0.5	0.5	0.7
Locomotor testing rearing	0.8	1.3	2.8	0.1	-1.7	-1.5	0.6	-1.2	-1.2	-0.9
Light reinforcement 1	0.3	0.5	1.4	-1.2	-0.0	-0.1	-0.9	0.5	0.6	0.6
Light reinforcement 2	0.3	0.4	1.3	-1.1	-0.1	-0.4	-1.0	0.5	0.5	0.4
Reaction time number correct	0.2	0.3	0.6	0.6	-0.3	-0.1	0.8	-0.6	-0.5	-0.6
Reaction time mean minus median	0.6	0.8	2.1	1.5	0.9	1.2	0.8	-0.0	-0.1	-0.4
Reaction time mean minus median AUC	0.4	0.5	1.2	0.5	1.0	1.1	0.1	0.5	0.5	0.5
Reaction time num false alarms	0.4	0.6	1.7	-1.3	0.1	0.0	-1.0	0.7	0.7	0.8
Reaction time num false alarms AUC	0.9	1.3	3.0	-1.7	0.4	0.2	-1.4	1.0	1.1	1.2
Reaction time trials correct on left	0.2	0.3	0.6	0.6	-0.3	-0.1	0.8	-0.6	-0.5	-0.6
Reaction time trials on left	0.2	0.3	0.6	0.6	-0.3	-0.1	0.7	-0.6	-0.5	-0.5
Reaction time mean	0.2	0.3	0.7	0.8	0.8	0.8	0.3	0.2	0.2	0.0
Reaction time mean AUC	0.4	0.5	1.2	0.5	1.1	1.1	-0.1	0.6	0.5	0.3
Median of all reaction times	0.1	0.1	0.4	0.6	0.5	0.5	0.1	0.2	0.1	-0.0
Reaction time omissions	0.8	1.1	2.1	-0.1	1.4	1.4	-0.5	1.0	1.0	1.0
Reaction time false alarm rate	1.3	1.8	3.8	-2.0	0.5	0.2	-1.8	1.3	1.3	1.5
Reaction time premature initiation rate	3.2	4.3	5.4	-1.3	2.3	2.1	-1.8	2.2	2.3	2.3
Reaction time premature initiations	1.4	2.1	2.8	-0.8	1.7	1.6	-1.0	1.5	1.6	1.6
Std. dev. reaction times	0.5	0.7	1.9	1.4	0.9	1.1	0.7	0.0	-0.0	-0.4
Reaction time trials completed	0.2	0.3	0.6	0.6	-0.3	-0.1	0.7	-0.6	-0.5	-0.5
Reaction time trials AUC	0.2	0.3	0.5	0.5	-0.4	-0.2	0.7	-0.6	-0.5	-0.6
Social response proportion	3.6	3.9	5.0	2.0	-1.8	-1.4	2.2	-2.2	-2.2	-1.8
Social responses	3.0	3.8	5.0	1.7	-2.0	-1.5	2.1	-2.2	-2.2	-1.9
Social time	0.8	1.1	1.8	1.4	-0.7	-0.4	1.3	-1.1	-1.1	-1.1
Conditioned locomotion	1.9	2.3	3.0	-1.2	1.5	1.4	-1.5	1.7	1.7	1.4
Cocaine response after cond. corrected	0.8	0.9	2.3	-0.2	-1.4	-1.5	0.2	-0.9	-0.9	-0.6
Cocaine response after cond. not corrected	0.7	0.8	2.4	-0.7	-1.3	-1.5	-0.3	-0.5	-0.6	-0.1
Cocaine response before conditioning	0.5	0.6	0.8	-0.6	0.7	0.7	-0.7	0.8	0.8	0.9
Saline control response	0.2	0.3	0.9	0.6	0.8	1.0	0.4	0.2	0.3	-0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.4	0.7	0.7	-0.0	0.4	0.3	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.5	0.1	0.1	0.3	-0.1	-0.2	-0.3
Condit. Reinf. active responses	0.2	0.3	0.7	0.7	0.8	0.8	0.2	0.3	0.3	-0.1
Condit. Reinf. inactive responses	0.2	0.3	0.8	0.7	0.8	0.9	0.3	0.2	0.2	-0.1
Condit. Reinf. lever presses	0.3	0.5	0.8	-0.1	0.9	0.8	-0.4	0.7	0.7	0.6
Condit. Reinf. lever reinforcers received	0.2	0.2	0.6	0.6	0.7	0.8	0.1	0.3	0.3	0.0
Pavlov. Cond. lever latency	1.2	1.7	4.9	-1.4	-1.9	-2.2	-0.6	-0.6	-0.6	0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.3	0.3	0.2	-0.3	0.3	0.3	0.4
Pavlov. Cond. change in total contacts	0.1	0.2	0.5	0.7	0.3	0.4	0.4	-0.1	-0.1	-0.5
Pavlov. Cond. index score	0.4	0.6	1.7	0.5	1.2	1.3	0.1	0.5	0.5	0.1
Pavlov. Cond. latency score	0.5	0.7	1.9	0.3	1.3	1.4	-0.1	0.7	0.7	0.2
Pavlov. Cond. lever contacts	1.0	1.3	3.6	1.5	1.6	1.9	0.7	0.4	0.4	-0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	-0.1	-0.1	-0.4	0.2	0.2	0.3
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.3	-0.0	0.1	0.2	-0.1	-0.1	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.7	0.3	1.2	1.3	-0.1	0.7	0.7	0.3
Pavlov. Cond. response bias	0.5	0.7	1.6	1.3	0.9	1.1	0.7	0.0	0.0	-0.5
Conditioned reinforcement - actives	0.2	0.2	0.5	0.3	-0.2	0.1	0.5	-0.4	-0.3	-0.7
Conditioned reinforcement - inactives	0.3	0.3	1.0	0.4	-0.4	-0.4	0.4	-0.5	-0.5	-1.0
Conditioned locomotion	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.3	0.2	0.1	-0.5
Intermittent access intake day 1-15 change	1.1	1.1	1.7	1.1	-0.7	-0.5	1.3	-1.1	-1.0	-1.3
Intermittent access intake escalation	0.6	0.6	1.1	1.0	-0.5	-0.4	1.1	-0.9	-0.8	-0.8
Intermittent access intake escalation 2	0.3	0.3	0.5	0.7	-0.3	-0.3	0.7	-0.5	-0.5	-0.6
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.7	0.7	0.8	0.8	0.3	0.3	0.3	0.4
Intermitt. access day 15 inactive lever presses	2.6	2.9	3.9	1.8	-1.3	-1.1	2.0	-1.8	-1.8	-1.9
Intermitt. access escalation Index	0.4	0.3	0.6	0.8	-0.3	0.0	0.8	-0.6	-0.6	-0.5
Intermittent access day 1 total infusions	0.2	0.2	0.5	-0.5	0.2	0.1	-0.5	0.4	0.3	-0.7
Intermittent access day 15 total infusions	0.5	0.5	2.0	0.3	-0.6	-0.6	0.5	-0.6	-0.6	-1.4
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.9	0.2	-0.5	-0.4	0.4	-0.5	-0.6	-1.4
Intermittent access total infusions	0.2	0.2	0.9	-0.3	-0.3	-0.4	-0.1	-0.1	-0.1	-0.9
Intermittent access day 1 locomotion	0.4	0.5	0.9	-0.3	0.9	0.9	-0.6	0.8	0.7	-0.2
Intermittent access day 15 total locomotion	0.8	0.8	2.3	0.7	-0.7	-0.6	0.8	-0.8	-0.9	-1.5
Intermittent access total locomotion	0.4	0.5	1.8	0.2	-0.6	-0.5	0.4	-0.5	-0.6	-1.3
Intermittent access standard deviation	0.6	0.6	1.4	-0.1	1.2	1.2	-0.4	0.9	0.9	0.3
Cocaine induced anxiety	1.5	1.8	3.2	0.3	-1.8	-1.8	1.0	-1.5	-1.4	-1.0
Post-drug Anxiety	1.0	1.1	1.5	0.7	-1.2	-1.0	1.1	-1.2	-1.1	-1.1
Baseline Anxiety	0.3	0.4	0.9	1.0	0.1	0.5	0.7	-0.4	-0.4	-0.7
Lifetime Intake	0.2	0.2	0.5	-0.6	-0.3	-0.4	-0.4	0.1	0.0	-0.7
Incentive Sensitization - Responses	0.3	0.3	0.7	0.4	-0.4	-0.4	0.5	-0.5	-0.5	-0.8
Incentive Sensitization - Breakpoint	0.2	0.2	0.7	0.4	-0.3	-0.4	0.5	-0.4	-0.4	-0.8
Progressive ratio test 1 active lever presses	0.3	0.3	1.1	0.3	-0.3	-0.1	0.4	-0.4	-0.4	-1.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.6	0.2	0.1	0.2	0.1	-0.0	-0.1	-0.8
Progressive ratio test 1 inactive lever presses	1.3	1.3	2.9	0.3	-1.6	-1.7	0.7	-1.2	-1.2	-0.7
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.1	-0.3	-0.4	0.1	-0.2	-0.2	-0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.7	0.1	-0.4	-0.4	0.3	-0.4	-0.4	-0.8
Progressive ratio test 2 inactive lever presses	1.5	1.7	3.4	1.0	-1.1	-1.0	1.3	-1.3	-1.3	-1.9
Total sessions with >9 infusions	0.4	0.4	1.0	-1.0	0.3	0.2	-0.8	0.6	0.7	0.5
Short access day 1 total inactive lever presses	1.2	1.3	4.1	-0.9	-1.7	-2.0	-0.2	-0.8	-0.8	-0.2
Short access day 10 total inactive lever presses	0.2	0.3	0.6	0.0	0.7	0.5	-0.3	0.5	0.5	0.7
Short access day 1 total infusions	0.9	0.9	1.5	-1.2	0.6	0.3	-1.2	1.0	1.0	1.0
Short access day 10 total infusions	0.4	0.4	0.9	-0.9	0.4	0.3	-0.9	0.8	0.7	-0.1
Short access total infusions	1.0	1.1	2.1	-1.4	0.7	0.4	-1.4	1.2	1.1	0.6
Short access day 1 locomotion	3.3	3.5	4.4	-1.9	1.6	1.3	-2.1	2.1	2.1	1.9
Short access day 10 total locomotion	0.8	0.9	1.1	-0.9	0.9	0.8	-1.0	1.1	1.0	0.9
Short access total locomotion	3.8	3.9	4.9	-1.5	2.1	1.9	-2.0	2.2	2.2	1.8
Compulsive drug intake	1.8	1.8	3.4	-0.3	1.7	1.8	-0.8	1.4	1.4	1.3
One hour access (0.3 mA shock)	0.1	0.1	0.6	-0.3	-0.1	-0.2	-0.1	-0.0	-0.0	-0.8
One hour access (shock baseline)	0.9	1.1	2.4	0.1	-1.2	-1.2	0.6	-1.0	-1.0	-1.5
Number of responses in last shaping day	0.5	0.5	1.4	-0.8	0.3	0.2	-0.6	0.5	0.6	1.2
Context. condit. distance diff. score	1.9	2.3	5.3	-0.0	2.2	2.3	-0.7	1.5	1.5	0.8
Locomotion velocity, session 1	2.4	2.5	5.1	2.3	-0.7	-0.4	2.0	-1.6	-1.6	-1.8
Locomotion distance, session 1	1.0	1.3	1.7	-1.0	1.1	1.1	-1.1	1.2	1.3	1.2
Locomotion velocity, session 2	1.6	1.9	3.7	1.9	-0.6	-0.2	1.9	-1.4	-1.3	-1.5
Locomotion distance, session 2	0.6	0.8	2.8	0.6	1.3	1.7	0.3	0.5	0.7	0.2
Locomotion velocity, session 3	2.2	2.6	4.2	-0.7	2.0	2.1	-1.1	1.7	1.8	1.5
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	0.1	0.1	-0.1	0.1	0.3	0.4
Stereotopy head waving bouts, day 3	0.8	1.0	1.5	-0.5	1.2	1.2	-0.7	1.0	1.1	1.0
Stereotopy head waving duration, day 3	0.7	0.8	2.1	0.2	1.4	1.4	-0.3	0.9	0.9	0.5
Locomotion velocity, session 7	0.1	0.1	0.2	0.1	-0.4	-0.4	0.4	-0.4	-0.4	-0.4
Locomotion distance, session 7	0.1	0.2	0.4	0.6	0.5	0.7	0.4	0.0	0.1	-0.4
Stereotopy head waving bouts, day 7	0.1	0.2	0.4	-0.0	0.6	0.6	-0.3	0.5	0.4	0.2
Stereotopy head waving duration, day 7	0.3	0.4	0.7	-0.8	0.3	0.2	-0.7	0.6	0.6	0.8
Locomotion velocity, session 8	0.6	0.7	1.8	1.2	0.9	1.3	0.8	0.0	0.1	-0.5
Locomotion distance, session 8	3.4	5.1	13.2	0.3	3.3	3.6	-0.8	2.2	2.2	1.1
Degree of sensitization distance	0.6	0.6	1.4	1.1	1.0	1.2	0.4	0.2	0.1	-0.5
Degree of sensitization stereotypy	0.0	0.0	0.2	-0.1	-0.3	-0.4	-0.1	-0.1	-0.2	-0.1
Condit. Reinf. active minus inactive responses	1.9	2.1	2.9	1.6	-1.2	-0.9	1.7	-1.6	-1.6	-1.4
Condit. Reinf. active-inactive response ratio	3.7	4.0	8.1	2.9	-0.8	-0.3	2.6	-1.9	-2.0	-2.3
Condit. Reinf. active responses	0.6	0.7	1.1	0.9	-0.7	-0.5	1.1	-1.0	-0.9	-0.8
Condit. Reinf. inactive responses	0.6	0.7	1.8	-1.3	0.1	-0.1	-1.0	0.6	0.7	1.0
Incentive salience index mean	1.2	1.4	1.9	1.0	-1.2	-1.0	1.3	-1.4	-1.3	-1.0
Condit. Reinf. lever presses	0.0	0.1	0.2	-0.4	-0.3	-0.3	-0.0	-0.1	-0.0	0.3
Time in familiar zone, hab. session 1	0.2	0.1	0.2	-0.3	0.5	0.4	-0.3	0.4	0.4	0.3
Time in novel zone, hab. session 1	0.2	0.2	0.5	-0.5	-0.5	-0.7	-0.3	-0.1	-0.1	0.2
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.2	-0.1	0.0	0.2	-0.2	-0.1	-0.0
Total locomotion distance, hab. session 1	0.1	0.1	0.3	-0.5	-0.2	-0.2	-0.2	0.0	0.1	0.3
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.2	-0.2	-0.1	0.3	-0.2	-0.2	-0.2
Time in familiar zone, hab. session 2	0.5	0.6	1.5	0.4	1.2	1.2	-0.2	0.7	0.6	0.1
Time in novel zone, hab. session 2	0.8	0.8	2.0	-0.5	-1.4	-1.4	0.2	-0.8	-0.7	-0.1
Total zone transitions, hab. session 2	0.3	0.4	0.8	0.0	-0.9	-0.8	0.4	-0.7	-0.6	-0.2
Total locomotion distance, hab. session 2	0.6	0.7	1.1	0.4	-1.1	-0.9	0.9	-1.0	-0.9	-0.7
Locomotion velocity, hab. session 2	0.6	0.8	1.4	0.3	-1.2	-1.1	0.8	-1.1	-1.0	-0.6
Novel to familiar place preference ratio	1.8	1.9	2.4	1.2	-1.3	-1.2	1.4	-1.5	-1.5	-1.4
Novelty place preference	1.9	1.9	2.5	1.2	-1.4	-1.2	1.4	-1.5	-1.6	-1.4
Time in novel zone, NPP test	1.7	1.8	2.2	1.1	-1.3	-1.2	1.3	-1.5	-1.5	-1.3
Total zone transitions, NPP test	0.9	1.3	1.7	-1.1	1.1	1.0	-1.1	1.2	1.3	1.2
Total locomotion distance, NPP test	0.2	0.3	0.4	-0.5	0.5	0.5	-0.5	0.6	0.6	0.6
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.4	0.2	0.2	-0.4	0.4	0.4	0.4
Pavlov. Cond. lever latency	1.0	1.3	1.6	1.0	-1.1	-1.1	1.1	-1.2	-1.3	-1.2
Pavlov. Cond. magazine entry latency	1.6	2.1	3.9	-0.6	1.9	2.0	-0.9	1.5	1.6	1.2
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	-0.0	-0.8	-0.7	0.4	-0.7	-0.6	-0.2
Pavlov. Cond. index score	2.0	2.6	4.4	-0.8	2.0	2.1	-1.1	1.7	1.8	1.4
Pavlov. Cond. latency score	1.7	2.2	3.5	-0.7	1.8	1.9	-1.0	1.6	1.6	1.3
Pavlov. Cond. lever contacts	1.1	1.3	2.0	-0.7	1.3	1.4	-0.8	1.2	1.3	1.1
Pavlov. Cond. magazine entry number	1.5	1.9	4.3	0.2	-1.9	-2.1	0.6	-1.3	-1.4	-1.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	-1.1	-0.4	-0.8	-0.9	0.3	0.2	0.6
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.0	5.0	-0.8	2.1	2.2	-1.1	1.8	1.9	1.5
Pavlov. Cond. response bias	1.5	1.8	2.8	-0.8	1.6	1.7	-0.9	1.3	1.5	1.3
Bone: apparent density	0.6	0.9	1.8	-1.0	0.7	0.6	-1.0	1.0	1.0	1.3
Bone surface	0.1	0.1	0.3	-0.5	-0.4	-0.5	-0.1	-0.1	-0.1	0.5
Bone volume	0.1	0.2	0.7	-0.8	-0.2	-0.3	-0.4	0.1	0.2	0.8
Bone: connectivity density	0.5	0.8	1.1	-0.8	0.8	0.8	-0.8	0.9	1.0	1.1
Bone: cortical apparent density	0.3	0.4	1.1	-0.2	-0.9	-1.1	0.0	-0.5	-0.5	0.0
Bone: cortical area	1.1	1.6	4.5	-0.5	-2.0	-2.1	0.3	-1.2	-1.1	-0.2
Bone: cortical porosity	0.2	0.2	0.5	-0.7	0.0	-0.2	-0.6	0.4	0.3	0.5
Bone: cortical porosity	0.2	0.2	0.3	-0.4	0.5	0.4	-0.6	0.6	0.5	0.5
Bone: cortical thickness	0.6	1.0	2.3	-1.4	-1.3	-1.5	-0.7	-0.3	-0.2	0.8
Bone: cortical thickness	1.9	2.2	3.0	-1.5	1.2	1.0	-1.6	1.6	1.6	1.7
Bone: cortical tissue density	0.3	0.4	1.3	-0.1	-1.0	-1.1	0.2	-0.6	-0.6	-0.1
Bone: elastic displacement	1.3	1.5	1.8	-1.1	1.1	1.0	-1.3	1.4	1.3	1.2
Bone: elastic work	0.9	1.2	2.4	-1.6	0.3	0.1	-1.5	1.0	1.0	1.4
Bone: endosteal estimation	0.1	0.1	0.4	-0.0	-0.5	-0.6	0.1	-0.3	-0.3	-0.0
Bone: endosteal perimeter	0.5	0.9	2.0	0.3	-1.3	-1.4	0.5	-1.0	-1.0	-0.7
Bone: final force	0.1	0.2	0.6	-0.2	-0.6	-0.8	0.0	-0.4	-0.3	0.1
Bone: final moment	0.2	0.3	0.9	-0.4	-0.7	-0.9	-0.1	-0.3	-0.3	0.2
Bone: marrow area	0.0	0.1	0.3	0.1	-0.4	-0.5	0.1	-0.3	-0.3	-0.1
Bone: maximum diameter	3.5	6.4	10.3	1.1	-3.2	-3.2	2.0	-2.8	-2.8	-1.9
Bone: maximum force	0.1	0.2	0.5	-0.6	-0.5	-0.7	-0.3	-0.1	-0.0	0.4
Bone: maximum moment	0.2	0.3	0.8	-0.8	-0.6	-0.9	-0.5	-0.0	-0.0	0.5
Bone: minimum diameter	0.1	0.2	0.3	-0.6	0.1	-0.1	-0.5	0.3	0.3	0.5
Bone: periosteal estimation	0.4	0.9	2.6	-0.3	-1.4	-1.6	0.2	-0.9	-0.9	-0.2
Bone: periosteal perimeter	0.9	1.5	3.7	-0.0	-1.8	-1.9	0.5	-1.2	-1.2	-0.7
Bone: post-yield work	0.1	0.1	0.5	-0.1	-0.5	-0.7	0.1	-0.4	-0.3	-0.1
Bone: stiffness	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	-0.1	0.0
Bone: tissue strength	0.2	0.2	0.3	0.5	-0.4	-0.4	0.4	-0.5	-0.5	-0.4
Bone: trabecular number	0.5	0.8	1.3	-1.1	0.5	0.4	-1.1	0.9	0.9	1.0
Bone: trabecular spacing	1.0	1.3	1.9	0.7	-1.4	-1.3	1.0	-1.3	-1.3	-1.0
Bone: trabecular thickness	2.1	2.6	3.1	-1.3	1.6	1.5	-1.6	1.8	1.7	1.7
Bone: trabecular tissue density	0.6	0.8	2.2	1.5	0.1	0.3	1.2	-0.6	-0.7	-1.1
Breakpoint value in progressive ratio session	0.8	0.9	1.9	-0.0	-1.3	-1.4	0.4	-1.0	-1.0	-0.9
Distance traveled before self-admin	0.5	0.5	1.5	-1.2	-0.3	-0.5	-1.0	0.4	0.4	0.6
Distance traveled after self-admin	0.6	0.6	1.4	-1.2	-0.1	-0.5	-0.9	0.5	0.5	1.1
Delta time in closed arm before/after self-admin	3.1	3.1	6.0	-0.5	2.5	2.2	-1.2	2.0	1.9	1.0
Delta time in open arm before/after self-admin	5.4	5.1	9.2	0.5	-3.0	-3.0	1.5	-2.5	-2.5	-1.7
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	-0.4	0.5	0.4	-0.6	0.6	0.5	-0.1
Extinction: sum of active levers before priming	0.9	0.9	1.2	0.8	-0.9	-0.7	1.1	-1.1	-1.1	-1.0
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.7	-0.3	-0.4	-0.5	0.1	0.1	-0.0
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.4	0.5	0.4	0.1	0.2	0.2	0.5
Delta ambulatory time before/after self-admin	0.3	0.3	1.0	0.3	0.8	0.6	-0.0	0.4	0.4	1.0
Time in closed arm before self-admin	0.3	0.3	0.6	-0.7	-0.5	-0.7	-0.4	-0.0	-0.1	0.8
Time in closed arm after self-admin	1.7	1.7	2.5	-0.7	1.6	1.4	-1.2	1.5	1.5	1.1
Time in open arm before self-admin	1.1	1.2	3.2	0.2	1.6	1.8	-0.3	1.1	1.1	0.3
Time in open arm after self-admin	1.6	1.8	3.6	1.3	-0.9	-0.5	1.5	-1.4	-1.4	-1.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.0	-0.7	-0.6	0.3	-0.5	-0.4	0.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.3	0.3	0.3	-0.4	0.4	0.4	0.2
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.5	-0.5	0.3	0.3	-0.6	0.5	0.5	0.7
Time to tail flick, test, before self-admin	0.4	0.3	0.6	-0.2	0.7	0.8	-0.4	0.6	0.6	0.7
Time to tail flick, test, after self-admin	0.8	0.8	2.4	-0.9	-1.4	-1.5	-0.3	-0.5	-0.5	0.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.0	-0.0	-0.1
Delta time to tail flick, test, before/after SA	0.8	0.7	1.5	0.1	-1.2	-1.2	0.5	-0.9	-0.8	-0.8
Ambulatory time before self-admin	1.0	1.0	3.2	-1.8	-0.4	-0.7	-1.4	0.6	0.6	0.8
Ambulatory time after self-admin	0.5	0.5	1.1	-1.1	-0.2	-0.6	-0.8	0.4	0.4	1.0
Total heroin consumption	0.1	0.1	0.5	-0.1	-0.3	-0.2	0.0	-0.2	-0.2	-0.7
Area under the delay curve	1.9	2.0	4.7	0.0	-2.0	-2.2	0.6	-1.4	-1.4	-1.2
Delay disc. indifference point, 0s delay	0.4	0.4	1.4	-0.4	-1.0	-1.2	-0.0	-0.5	-0.5	-0.2
Delay disc. indifference point, 16s delay	3.4	3.5	4.4	1.1	-2.0	-2.0	1.6	-2.0	-2.0	-2.1
Delay disc. indifference point, 2s delay	0.7	0.8	2.2	-1.5	-0.7	-1.1	-1.0	0.3	0.3	0.6
Delay disc. indifference point, 24s delay	1.3	1.3	1.7	0.8	-1.3	-1.2	1.1	-1.3	-1.3	-0.9
Delay disc. indifference point, 4s delay	1.0	1.1	3.6	-0.8	-1.5	-1.9	-0.2	-0.7	-0.7	-0.0
Delay disc. indifference point, 8s delay	1.0	1.1	1.7	0.4	-1.2	-1.3	0.7	-1.0	-1.1	-1.2
Delay discount exponential model param	1.6	1.7	4.2	0.1	1.8	2.0	-0.5	1.2	1.3	1.1
Delay discount hyperbolic model param	1.5	1.6	4.1	0.2	1.8	2.0	-0.4	1.2	1.2	0.9
Fecal boli incidents, locomotor time 1	0.1	0.1	0.4	0.3	0.4	0.7	0.2	0.1	0.1	0.3
Change in fecal boli incidents, locomotor task	0.8	0.8	1.4	1.2	-0.5	-0.4	1.1	-0.9	-0.9	-1.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.2	-0.0	0.0	0.2	-0.1	-0.1	0.1
Bouts of movement, locomotor time 1	2.0	2.2	3.0	1.6	-1.1	-0.8	1.7	-1.6	-1.6	-1.7
Total resting periods, locomotor time 1	2.0	2.2	3.3	1.8	-0.9	-0.5	1.8	-1.5	-1.5	-1.8
Rest time, locomotor task time 1	0.5	0.5	1.1	1.0	-0.4	-0.1	1.0	-0.8	-0.7	-0.6
Distance moved, locomotor task time 1	0.5	0.6	1.3	-1.2	-0.1	-0.4	-1.0	0.5	0.5	0.9
Vertical activity count, locomotor time 1	0.2	0.2	0.4	-0.7	-0.2	-0.4	-0.6	0.3	0.2	0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	0.4	-0.0	-0.0	0.3	-0.2	-0.3	-0.6
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.2	0.2	0.1	-0.2	0.2	0.2	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.3
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	0.2	0.4	0.3	-0.0	0.0	0.1
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.2	0.1	0.2	0.0	0.0	-0.0	0.0
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	0.0	0.1	-0.2	0.1	0.0	-0.1
Weight adjusted by age	0.4	0.5	1.3	-1.1	-0.5	-0.8	-0.8	0.2	0.2	0.7
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.2	0.3	0.2	0.2	0.1	0.0	-0.0	-0.4
Locomotion in novel chamber	2.9	3.6	6.0	-0.8	2.4	2.3	-1.5	2.2	2.1	1.4
Locomotion in novel chamber post-restriction	1.1	1.3	3.5	1.5	1.5	1.9	0.8	0.3	0.3	-0.6
Progressive ratio	0.2	0.2	0.4	-0.6	0.3	0.1	-0.6	0.5	0.4	0.3
Food seeking constrained by brief footshock	1.1	1.3	3.4	-1.9	-1.0	-1.4	-1.3	0.3	0.2	1.0
Seeking ratio, punishment vs. effort	0.2	0.3	0.8	-0.4	-0.8	-0.9	-0.1	-0.4	-0.3	0.2
Run reversals in cocaine runway, females	0.3	0.3	0.7	0.3	0.8	0.8	-0.1	0.5	0.4	-0.0
Run reversals in cocaine runway, males	0.2	0.2	0.6	-0.2	-0.6	-0.8	0.0	-0.3	-0.4	-0.1
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.8	0.2	-0.1	-0.7	0.5	0.5	0.6
Latency to leave start box in cocaine runway, F	0.4	0.4	1.0	-1.0	-0.3	-0.6	-0.8	0.3	0.3	0.8
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	0.1	0.7	0.7	-0.1	0.4	0.4	-0.1
Cd content in liver	0.4	0.4	0.5	-0.6	0.6	0.6	-0.6	0.7	0.7	0.7
Co content in liver	0.1	0.1	0.3	-0.5	0.2	0.2	-0.3	0.3	0.4	0.5
Cu content in liver	0.3	0.3	0.5	0.3	-0.7	-0.7	0.5	-0.7	-0.6	-0.3
Fe content in liver	1.8	2.1	5.3	2.3	0.0	0.4	1.9	-1.1	-1.1	-1.9
K content in liver	1.3	1.3	3.9	-2.0	-0.2	-0.5	-1.4	0.7	0.8	1.4
Mg content in liver	0.2	0.2	0.7	-0.9	-0.3	-0.4	-0.4	0.1	0.2	0.4
Mn content in liver	1.7	2.0	4.9	-2.2	0.4	0.1	-1.7	1.2	1.4	1.6
Na content in liver	3.7	3.9	5.4	1.1	-2.3	-2.2	1.7	-2.2	-2.2	-1.9
Rb content in liver	0.9	1.2	3.4	-1.0	-1.6	-1.8	-0.2	-0.7	-0.6	-0.2
Se content in liver	0.4	0.5	1.5	-0.9	-1.1	-1.2	-0.2	-0.4	-0.3	0.1
Sr content in liver	2.6	2.4	3.0	1.2	-1.6	-1.4	1.5	-1.7	-1.7	-1.5
Zn content in liver	0.1	0.1	0.4	-0.6	-0.4	-0.5	-0.2	-0.1	0.0	0.3