Alk

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000008683	0.29	0.12	0.0e+00	0.17	0.16	0.17	0.17	7.5e-19	2.6e-17	1.9e-18	2.0e-18
2	Brain	gene expression	ENSRNOG00000008683	0.11	0.08	7.4e-05	0.02	0.03	0.03	0.03	2.4e-03	1.1e-03	9.4e-04	4.1e-04
3	Brain	mRNA stability	ENSRNOG00000008683	0.21	0.11	1.9e-04	0.02	0.04	0.05	0.05	2.6e-03	3.0e-04	1.2e-05	9.6e-06
4	NAcc	gene expression	ENSRNOG00000008683	0.28	0.1	0.0e+00	0.23	0.28	0.27	0.27	7.6e-17	8.6e-21	2.4e-20	1.4e-20
5	PL	gene expression	ENSRNOG00000008683	0.06	0.05	3.2e-03	0.04	0.03	0.03	0.04	6.7e-04	2.8e-03	4.4e-03	1.1e-03
6	PL	mRNA stability	ENSRNOG00000008683	0.11	0.06	2.5e-08	0.08	0.11	0.08	0.1	7.7e-07	1.7e-08	7.6e-07	1.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	0.3	1.0	2.2	-1.5	-0.2	0.5	0.9	1.3	-1.0
BMI without tail	0.1	0.2	1.0	-0.4	-1.0	-0.0	-0.0	0.2	-0.0
Body weight	0.5	2.3	6.2	-2.5	-1.1	0.7	1.2	1.6	-1.3
Epididymis fat weight	8.9	20.7	28.2	-5.3	2.5	3.9	5.0	4.8	-5.1
Glucose	0.4	0.6	1.3	-0.9	0.5	1.1	0.6	0.9	-0.5
Heart weight	7.0	10.0	13.4	-3.7	2.1	2.9	3.3	3.5	-3.3
Left kidney weight	0.1	0.2	1.1	0.0	0.1	1.0	-0.0	0.0	-0.0
Right kidney weight	0.4	1.1	2.1	-1.4	0.1	1.2	0.9	1.1	-1.0
Tail length	0.1	0.2	0.7	-0.3	-0.8	0.2	-0.2	-0.3	0.3
Length with tail	0.2	0.9	2.7	-1.6	-0.5	0.6	0.8	0.9	-0.8
Length without tail	0.2	0.4	1.4	-1.2	0.2	0.5	0.5	0.6	-0.5
Liver weight, left	1.1	1.8	3.1	-1.7	-0.0	1.1	1.5	1.4	-1.5
Liver weight, right	5.5	9.1	12.4	-3.5	1.4	2.1	3.4	3.5	-3.5
Parametrial fat weight	3.6	7.0	12.7	-3.6	1.0	2.1	2.9	2.6	-3.0
Retroperitoneal fat weight	13.0	43.0	67.1	-8.2	3.4	5.9	6.9	7.2	-6.8
Intraocular pressure	1.4	2.0	3.7	-1.3	1.1	0.1	1.8	1.5	-1.9
Extensor digitorum longus weight	4.1	16.5	22.0	4.0	-3.4	-3.1	-4.7	-4.3	4.7
Soleus weight	5.4	15.8	19.2	3.7	-3.8	-3.8	-4.4	-3.8	4.3
Tibialis anterior weight	3.5	11.9	15.1	3.4	-2.8	-2.7	-3.9	-3.7	3.9
Tibia length	1.0	2.8	4.4	-2.0	0.1	1.8	1.6	2.1	-1.6
Number of licking bursts	0.9	1.0	1.6	0.7	-1.3	-1.2	-1.1	-0.6	1.0
Food consumed during 24 hour testing period	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.3	-0.0	0.2
Times rat made contact with spout	4.4	5.0	7.4	2.2	-1.2	-1.6	-2.6	-2.7	2.7
Mean time between licks in bursts	2.1	2.9	4.8	-1.8	0.8	1.0	2.0	2.2	-2.0
Mean num. licks in bursts	0.3	0.4	0.7	0.5	0.8	0.7	-0.3	-0.8	0.5
Std. dev. time between licks in bursts	0.1	0.2	0.5	0.1	-0.3	-0.7	0.2	0.5	-0.3
Water consumed over 24 hours	1.3	1.6	2.4	1.2	-0.9	-0.9	-1.4	-1.5	1.5
Indifference point 0 sec	0.2	0.3	0.7	0.1	0.7	0.3	-0.3	-0.8	0.5
Indifference point AUC	1.2	1.4	2.0	1.1	-1.3	-0.6	-1.4	-1.2	1.3
Indifference point function ln k	0.4	0.5	1.9	-0.4	1.4	0.5	0.6	0.3	-0.5
Indifference point function log k	0.4	0.5	1.9	-0.4	1.4	0.5	0.6	0.3	-0.5
Delay discounting total patch changes 0 sec	0.1	0.2	0.7	0.1	0.3	-0.0	-0.4	-0.9	0.6
Delay discounting total patch changes 12 sec	0.1	0.2	0.5	-0.7	0.1	0.3	0.4	0.2	-0.5
Delay discounting total patch changes 18 sec	0.4	0.6	1.1	0.4	-0.5	0.1	-0.9	-1.0	1.0
Delay discounting total patch changes 24 sec	0.4	0.5	1.0	-1.0	0.4	0.8	0.7	0.6	-0.6
Delay discounting total patch changes 6 sec	0.2	0.3	0.6	0.2	-0.6	-0.6	-0.6	-0.8	0.6
Delay discounting time to switch 0 sec	0.3	0.4	0.7	0.6	-0.8	-0.8	-0.6	-0.5	0.6
Delay discounting water rate 0 sec	0.2	0.4	0.9	-0.3	0.9	0.3	0.6	0.4	-0.7
Delay discounting water rate 12 sec	3.1	4.6	6.7	-2.5	1.4	1.4	2.5	2.2	-2.6
Delay discounting water rate 18 sec	0.8	1.1	1.9	-1.4	0.2	0.3	1.2	1.3	-1.3
Delay discounting water rate 24 sec	2.2	3.1	5.6	-2.4	0.4	0.8	1.9	2.1	-2.1
Delay discounting water rate 6 sec	1.6	2.4	3.3	-1.8	1.3	0.8	1.7	1.6	-1.8
Locomotor activity	0.2	0.2	0.6	0.7	0.3	-0.4	-0.3	-0.8	0.3
Locomotor testing distance	0.8	1.4	2.4	1.6	-0.4	-1.1	-1.1	-1.4	1.0
Locomotor testing rearing	0.7	1.1	1.4	1.2	-1.0	-0.9	-1.1	-1.0	0.9
Light reinforcement 1	4.3	7.8	10.0	2.6	-2.9	-1.6	-3.1	-3.1	3.2
Light reinforcement 2	3.0	4.0	4.8	2.2	-1.7	-1.4	-2.1	-2.2	2.2
Reaction time number correct	0.1	0.1	0.5	0.3	-0.0	-0.3	-0.3	-0.7	0.2
Reaction time mean minus median	0.2	0.3	0.8	0.5	0.7	0.9	0.0	-0.3	-0.0
Reaction time mean minus median AUC	0.4	0.5	1.6	0.0	1.3	0.9	0.5	0.0	-0.5
Reaction time num false alarms	1.4	1.9	6.2	0.6	-1.0	-2.5	-1.1	-1.2	1.0
Reaction time num false alarms AUC	1.9	2.6	7.8	0.9	-1.4	-2.8	-1.4	-1.2	1.3
Reaction time trials correct on left	0.1	0.1	0.5	0.3	-0.0	-0.3	-0.3	-0.7	0.2
Reaction time trials on left	0.1	0.1	0.5	0.3	-0.0	-0.3	-0.4	-0.7	0.2
Reaction time mean	0.3	0.5	1.7	-0.0	1.3	0.8	0.5	0.3	-0.4
Reaction time mean AUC	0.2	0.3	1.1	0.1	1.0	0.6	0.3	0.2	-0.3
Median of all reaction times	0.3	0.4	1.9	0.0	1.4	0.6	0.4	0.3	-0.3
Reaction time omissions	0.1	0.2	0.4	0.5	0.6	-0.3	-0.1	-0.5	0.1
Reaction time false alarm rate	1.1	1.5	4.7	0.6	-1.2	-2.2	-1.0	-0.7	1.0
Reaction time premature initiation rate	0.3	0.4	1.7	-0.3	-1.3	-0.6	-0.0	0.3	-0.1
Reaction time premature initiations	0.2	0.3	1.0	-0.2	-1.0	-0.7	-0.1	0.0	-0.0
Std. dev. reaction times	0.4	0.6	1.7	-0.1	1.3	1.1	0.6	0.2	-0.6
Reaction time trials completed	0.1	0.1	0.5	0.3	-0.0	-0.3	-0.4	-0.7	0.2
Reaction time trials AUC	0.1	0.2	0.7	0.5	0.0	-0.2	-0.4	-0.8	0.3
Social response proportion	0.2	0.2	0.5	-0.7	0.0	0.6	0.4	0.2	-0.5
Social responses	0.2	0.3	0.6	-0.2	-0.5	0.7	-0.7	-0.3	0.7
Social time	0.9	1.1	3.9	-1.0	0.9	2.0	0.7	0.5	-0.6
Conditioned locomotion	1.1	1.3	2.2	1.1	-0.8	-1.4	-1.1	-1.5	1.0
Cocaine response after cond. corrected	1.3	1.5	3.2	1.8	0.1	-0.9	-1.2	-1.4	1.1
Cocaine response after cond. not corrected	1.4	1.6	3.3	1.8	-0.3	-0.9	-1.2	-1.5	1.2
Cocaine response before conditioning	0.3	0.4	0.9	0.4	-1.0	-0.2	-0.6	-0.5	0.7
Saline control response	1.9	2.5	3.9	1.4	-1.4	-0.6	-1.9	-1.8	2.0
Condit. Reinf. active minus inactive responses	1.5	1.8	3.6	1.2	-1.4	-1.9	-1.3	-1.0	1.1
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.7	0.6	-1.2	-1.3	-0.7	-0.6	0.5
Condit. Reinf. active responses	0.6	0.9	1.6	0.9	-1.0	-1.3	-1.0	-0.6	0.8
Condit. Reinf. inactive responses	0.3	0.4	0.5	0.6	-0.6	-0.7	-0.7	-0.4	0.6
Condit. Reinf. lever presses	0.5	0.6	1.1	0.6	-1.0	-0.9	-0.9	-0.6	0.7
Condit. Reinf. lever reinforcers received	0.5	0.7	1.5	0.8	-1.0	-1.2	-0.8	-0.4	0.6
Pavlov. Cond. lever latency	1.1	1.4	2.2	-1.2	1.1	1.5	1.2	1.1	-1.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	-0.4	-0.2	-0.2	-0.1	0.2
Pavlov. Cond. change in total contacts	0.4	0.6	2.3	0.4	-0.7	-1.5	-0.5	-0.3	0.3
Pavlov. Cond. index score	0.2	0.3	0.6	0.6	-0.6	-0.8	-0.5	-0.3	0.4
Pavlov. Cond. latency score	0.2	0.3	0.4	0.6	-0.5	-0.6	-0.5	-0.3	0.4
Pavlov. Cond. lever contacts	0.7	1.0	2.6	0.7	-1.3	-1.6	-0.8	-0.5	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.3	0.6	0.5	0.2	-0.0	-0.1
Pavlov. Cond. intertrial magazine entries	2.8	3.6	4.1	-1.8	1.8	2.0	2.0	1.9	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	0.3	-0.3	-0.5	-0.2	-0.0	0.1
Pavlov. Cond. response bias	1.1	1.5	3.0	1.0	-1.6	-1.7	-1.1	-0.8	0.9
Conditioned reinforcement - actives	0.3	0.3	0.6	0.6	-0.6	0.3	-0.7	-0.4	0.8
Conditioned reinforcement - inactives	1.4	1.6	2.7	1.6	-1.0	0.1	-1.6	-0.9	1.7
Conditioned locomotion	0.2	0.2	1.3	-0.0	-0.3	1.1	-0.2	0.0	0.2
Intermittent access intake day 1-15 change	1.0	1.0	1.6	-1.0	0.7	0.4	1.2	1.1	-1.3
Intermittent access intake escalation	1.3	1.3	2.2	-1.2	0.8	0.4	1.4	1.2	-1.5
Intermittent access intake escalation 2	2.0	2.0	2.8	-1.4	1.1	1.0	1.6	1.5	-1.7
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.2	0.5	-0.4	-0.2	-0.5	0.2	0.5
Intermitt. access day 15 inactive lever presses	3.2	3.5	6.5	2.3	-0.5	0.2	-2.3	-1.9	2.6
Intermitt. access escalation Index	0.1	0.1	0.5	-0.1	-0.7	-0.4	0.2	0.1	-0.2
Intermittent access day 1 total infusions	4.9	5.5	7.2	2.6	-2.1	-1.5	-2.7	-2.3	2.7
Intermittent access day 15 total infusions	1.0	1.1	1.4	1.2	-1.0	-1.0	-1.1	-1.0	1.0
Intermittent access terminal intake (last 3 days)	0.9	1.0	1.9	1.4	-0.8	-0.6	-1.1	-0.8	1.0
Intermittent access total infusions	1.3	1.5	2.1	1.4	-1.3	-0.7	-1.3	-1.0	1.3
Intermittent access day 1 locomotion	2.0	2.1	3.0	1.6	-1.5	-0.5	-1.7	-1.2	1.7
Intermittent access day 15 total locomotion	0.4	0.4	1.0	0.6	-1.0	-0.1	-0.6	-0.3	0.6
Intermittent access total locomotion	0.2	0.3	0.7	0.6	-0.8	0.1	-0.5	-0.1	0.5
Intermittent access standard deviation	0.1	0.1	0.4	-0.2	0.0	0.4	0.2	0.6	-0.3
Cocaine induced anxiety	0.2	0.2	0.5	0.4	0.0	0.1	-0.5	-0.5	0.7
Post-drug Anxiety	0.2	0.2	0.6	-0.0	0.7	0.8	0.2	-0.2	-0.0
Baseline Anxiety	0.1	0.1	0.3	-0.3	-0.0	0.1	0.5	0.4	-0.6
Lifetime Intake	1.5	1.7	2.6	1.6	-1.2	-0.6	-1.5	-1.1	1.5
Incentive Sensitization - Responses	0.2	0.2	0.2	-0.4	-0.3	0.2	0.4	0.4	-0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.5	-0.4	0.3	0.5	0.5	-0.5
Progressive ratio test 1 active lever presses	0.3	0.3	0.6	0.8	-0.8	0.0	-0.6	0.2	0.6
Progressive ratio test 1 breakpoint	0.3	0.3	0.6	0.8	-0.8	-0.0	-0.5	0.3	0.5
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.6	1.3	-1.1	-0.5	-1.2	-0.2	1.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	0.2	-0.6	0.2	-0.2	0.0	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	0.3	-0.5	0.1	-0.2	0.0	0.1
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.0	1.0	-0.5	-0.0	-0.8	-0.5	0.8
Total sessions with >9 infusions	0.2	0.2	0.7	0.8	0.2	-0.3	-0.3	0.3	0.4
Short access day 1 total inactive lever presses	3.0	3.3	5.8	2.4	-1.8	-1.1	-2.0	-1.3	2.0
Short access day 10 total inactive lever presses	0.5	0.6	1.3	0.5	0.7	1.1	-0.7	-0.5	0.8
Short access day 1 total infusions	1.3	1.4	3.3	1.8	-0.7	-0.8	-1.3	-0.7	1.4
Short access day 10 total infusions	2.4	2.6	4.4	2.1	-1.1	-1.0	-1.9	-1.4	2.0
Short access total infusions	0.9	1.0	2.1	1.4	-0.6	-0.1	-1.2	-0.8	1.3
Short access day 1 locomotion	2.6	2.8	5.0	2.2	-0.9	-0.9	-2.0	-1.2	2.1
Short access day 10 total locomotion	0.5	0.5	1.6	1.3	-0.6	-0.2	-0.7	-0.0	0.7
Short access total locomotion	0.2	0.2	0.6	0.8	-0.0	0.5	-0.2	0.5	0.3
Compulsive drug intake	0.4	0.4	1.2	-0.6	1.1	0.6	0.6	0.1	-0.6
One hour access (0.3 mA shock)	0.9	1.0	2.0	1.4	-0.2	-0.5	-1.1	-1.1	1.2
One hour access (shock baseline)	1.2	1.4	2.3	1.5	-1.2	-1.0	-1.3	-0.7	1.3
Number of responses in last shaping day	0.2	0.2	0.9	0.3	-0.4	-0.9	-0.1	0.4	0.1
Context. condit. distance diff. score	0.3	0.4	1.2	-1.1	0.3	0.5	0.4	0.6	-0.4
Locomotion velocity, session 1	0.2	0.3	0.9	-0.0	0.7	0.9	0.3	0.1	-0.2
Locomotion distance, session 1	1.3	1.7	3.1	1.8	-0.6	-1.4	-1.2	-1.5	1.1
Locomotion velocity, session 2	0.0	0.0	0.2	0.1	0.3	0.0	-0.1	-0.4	0.1
Locomotion distance, session 2	0.2	0.3	0.5	0.7	-0.1	-0.7	-0.3	-0.6	0.3
Locomotion velocity, session 3	0.8	0.9	2.1	1.0	-0.4	-0.5	-1.0	-1.4	1.1
Locomotion distance, session 3	2.4	2.6	3.6	1.5	-1.3	-1.3	-1.8	-1.8	1.9
Stereotopy head waving bouts, day 3	0.9	1.0	1.7	1.3	-0.5	-0.4	-1.2	-1.1	1.2
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.3	0.1	0.2	-0.0	-0.2	0.1
Locomotion velocity, session 7	2.4	2.6	4.3	1.1	-2.1	-1.7	-1.5	-1.7	1.4
Locomotion distance, session 7	0.3	0.3	1.4	0.1	-0.7	-1.2	-0.2	-0.2	0.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.2	0.5	0.1	-0.1	-0.1	0.2
Stereotopy head waving duration, day 7	0.6	0.7	1.3	1.0	0.3	-0.2	-0.8	-1.2	1.0
Locomotion velocity, session 8	0.2	0.2	0.7	0.5	0.0	0.2	-0.5	-0.8	0.5
Locomotion distance, session 8	0.2	0.3	0.6	0.1	-0.5	-0.8	-0.5	-0.5	0.4
Degree of sensitization distance	1.5	1.5	2.5	-1.4	0.5	0.1	1.4	1.6	-1.6
Degree of sensitization stereotypy	0.1	0.1	0.3	0.2	0.1	-0.5	-0.2	-0.2	0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.2	-0.7	-0.5	0.0	0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.2	-0.4	0.2	-0.3	-0.4	0.4
Condit. Reinf. active responses	1.2	1.4	3.4	1.4	-1.3	-1.8	-0.9	-0.5	0.8
Condit. Reinf. inactive responses	0.9	1.1	3.5	1.3	-0.6	-1.9	-0.7	-0.3	0.4
Incentive salience index mean	1.3	1.5	2.5	1.4	-1.3	-1.6	-1.0	-0.8	1.0
Condit. Reinf. lever presses	2.9	3.9	5.9	2.2	-1.6	-2.4	-1.8	-1.8	1.8
Time in familiar zone, hab. session 1	0.2	0.2	0.6	-0.5	0.5	0.8	0.1	-0.1	0.0
Time in novel zone, hab. session 1	1.0	1.0	1.6	-1.0	0.5	0.4	1.1	1.2	-1.2
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.5	0.3	-0.5	0.1	0.1	-0.1
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.3	0.3	0.2	0.2	0.3	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.9	1.0	-0.6	-0.5	-0.6	-0.3	0.6
Time in familiar zone, hab. session 2	0.4	0.4	0.6	0.4	0.4	0.7	-0.5	-0.8	0.7
Time in novel zone, hab. session 2	0.7	0.7	1.2	-1.0	0.0	-0.1	0.9	1.1	-1.1
Total zone transitions, hab. session 2	0.2	0.2	0.6	0.5	0.2	-0.3	-0.4	-0.8	0.5
Total locomotion distance, hab. session 2	0.2	0.2	0.5	0.3	-0.4	0.0	-0.6	-0.6	0.7
Locomotion velocity, hab. session 2	0.4	0.5	0.8	0.5	-0.6	-0.2	-0.8	-0.9	0.9
Novel to familiar place preference ratio	2.2	2.3	3.3	-1.4	1.5	0.8	1.6	1.8	-1.7
Novelty place preference	2.8	2.9	3.9	-1.7	1.6	1.0	1.8	2.0	-1.9
Time in novel zone, NPP test	2.7	2.9	3.7	-1.7	1.7	1.0	1.8	1.9	-1.9
Total zone transitions, NPP test	1.8	2.6	3.0	1.7	-1.3	-1.7	-1.5	-1.6	1.6
Total locomotion distance, NPP test	1.1	1.5	2.0	1.4	-1.1	-1.4	-1.2	-1.0	1.2
Locomotion velocity, NPP test	2.2	3.2	4.3	2.1	-1.5	-1.6	-1.9	-1.7	1.9
Pavlov. Cond. lever latency	2.8	3.5	4.9	-2.2	1.0	1.6	2.0	2.1	-2.1
Pavlov. Cond. magazine entry latency	0.6	0.8	1.4	0.6	-1.2	-0.8	-0.9	-0.7	1.0
Pavlov. Cond. change in total contacts	0.8	0.9	1.1	1.0	-0.9	-1.0	-0.9	-0.7	1.0
Pavlov. Cond. index score	1.4	1.9	2.4	1.5	-1.1	-1.2	-1.4	-1.3	1.5
Pavlov. Cond. latency score	1.3	1.7	2.2	1.4	-1.0	-1.2	-1.4	-1.3	1.5
Pavlov. Cond. lever contacts	2.1	2.5	3.1	1.8	-1.2	-1.5	-1.6	-1.6	1.7
Pavlov. Cond. magazine entry number	0.5	0.7	1.0	-0.8	0.8	0.7	0.9	0.7	-1.0
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.6	1.3	0.5	-0.8	-0.6	-0.8	0.5
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.1	3.7	1.9	-1.4	-1.7	-1.9	-1.7	1.9
Pavlov. Cond. response bias	1.6	2.0	2.8	1.6	-1.0	-1.1	-1.5	-1.5	1.7
Bone: apparent density	3.3	5.4	11.6	3.4	-0.0	-1.6	-2.3	-2.7	2.3
Bone surface	1.4	2.5	5.7	2.4	0.2	-0.8	-1.6	-1.9	1.7
Bone volume	1.8	3.0	6.8	2.6	0.3	-0.9	-1.7	-2.0	1.8
Bone: connectivity density	3.3	5.2	11.7	3.4	-0.2	-1.8	-2.2	-2.6	2.2
Bone: cortical apparent density	0.1	0.1	0.4	0.7	0.0	0.4	-0.3	-0.1	0.2
Bone: cortical area	0.2	0.3	0.4	0.6	-0.5	-0.4	-0.6	-0.5	0.7
Bone: cortical porosity	0.6	0.7	1.4	1.0	0.9	-1.2	-0.3	-0.8	0.3
Bone: cortical porosity	0.7	0.7	1.4	1.1	0.9	-1.2	-0.3	-0.8	0.3
Bone: cortical thickness	0.1	0.2	0.4	-0.6	0.4	0.3	0.4	0.5	-0.4
Bone: cortical thickness	0.3	0.4	1.3	0.7	-0.2	-1.1	-0.4	-0.5	0.3
Bone: cortical tissue density	0.1	0.1	0.4	0.6	0.2	0.6	-0.1	0.0	0.1
Bone: elastic displacement	0.2	0.2	0.6	0.7	-0.3	-0.8	0.0	0.0	-0.2
Bone: elastic work	0.6	0.8	2.0	1.4	-0.5	-1.3	-0.5	-0.5	0.4
Bone: endosteal estimation	0.4	0.9	1.2	1.1	-0.8	-0.6	-1.0	-1.0	1.1
Bone: endosteal perimeter	0.4	0.8	1.1	0.9	-1.0	-0.4	-0.9	-0.7	1.0
Bone: final force	0.2	0.3	0.6	0.8	0.8	0.1	-0.2	-0.5	0.2
Bone: final moment	0.1	0.2	0.5	0.7	0.7	0.1	-0.2	-0.6	0.3
Bone: marrow area	0.5	1.1	1.4	1.1	-0.9	-0.7	-1.1	-1.1	1.2
Bone: maximum diameter	0.9	1.6	2.4	1.5	-0.8	-0.6	-1.5	-1.4	1.5
Bone: maximum force	0.0	0.0	0.1	0.2	0.3	0.1	-0.1	-0.1	0.2
Bone: maximum moment	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.2	0.2
Bone: minimum diameter	0.1	0.2	0.5	0.3	-0.4	-0.0	-0.5	-0.6	0.7
Bone: periosteal estimation	0.6	1.2	1.6	1.3	-0.8	-0.8	-1.2	-1.1	1.3
Bone: periosteal perimeter	0.3	0.6	1.0	0.5	-1.0	-0.7	-0.8	-0.6	0.8
Bone: post-yield work	0.5	0.7	1.3	0.7	-0.7	-0.4	-1.0	-0.8	1.1
Bone: stiffness	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.0	0.1	0.1
Bone: tissue strength	0.2	0.2	0.4	-0.5	0.7	0.2	0.4	0.3	-0.3
Bone: trabecular number	2.7	4.2	10.2	3.2	0.0	-1.3	-2.0	-2.4	1.9
Bone: trabecular spacing	0.5	0.6	1.8	-1.3	-0.3	0.4	0.7	0.9	-0.6
Bone: trabecular thickness	0.4	0.5	0.9	0.9	0.2	-0.4	-0.6	-0.9	0.7
Bone: trabecular tissue density	0.0	0.0	0.2	0.1	0.1	0.4	-0.2	-0.0	0.2
Breakpoint value in progressive ratio session	0.6	0.7	1.3	1.1	-0.6	-0.3	-0.9	-0.7	1.0
Distance traveled before self-admin	0.5	0.5	1.5	0.1	-1.2	-0.8	-0.7	0.1	0.7
Distance traveled after self-admin	0.2	0.3	0.6	-0.3	-0.7	-0.7	-0.0	0.6	-0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.5	-0.1	0.7	-0.4	0.3	0.2	-0.2
Delta time in open arm before/after self-admin	1.1	1.0	1.5	0.8	-0.9	0.6	-1.2	-1.2	1.2
Diff in mean of infusions in LGA sessions	0.3	0.3	0.8	0.6	0.5	0.9	-0.4	-0.5	0.5
Extinction: sum of active levers before priming	1.8	1.8	3.9	0.9	-1.4	-2.0	-1.3	-1.1	1.2
Active lever presses in extinction session 6	0.4	0.4	2.0	0.1	0.3	1.4	0.1	0.1	-0.1
Delta distance traveled before/after self-admin	1.3	1.4	2.1	-1.1	1.1	1.4	1.2	1.1	-1.2
Delta ambulatory time before/after self-admin	0.4	0.4	0.7	-0.4	0.5	0.8	0.7	0.6	-0.7
Time in closed arm before self-admin	0.9	1.0	1.6	-1.1	0.1	1.0	1.0	1.3	-1.0
Time in closed arm after self-admin	0.9	0.9	1.9	-1.1	0.4	0.6	1.0	1.4	-0.9
Time in open arm before self-admin	0.5	0.5	2.1	0.6	-0.2	-1.5	-0.3	-0.6	0.3
Time in open arm after self-admin	3.0	3.3	4.4	2.0	-1.3	-1.2	-2.0	-2.1	2.0
Sum of active levers in priming session hrs 5-6	1.4	1.3	2.5	1.3	0.3	-0.3	-1.3	-1.6	1.5
Time to tail flick, vehicle, before self-admin	1.6	1.6	3.0	-1.3	0.5	0.2	1.5	1.7	-1.6
Time to tail flick, vehicle, after self-admin	1.2	1.3	2.7	-1.4	0.7	1.6	1.0	0.9	-0.9
Time to tail flick, test, before self-admin	0.5	0.5	0.8	0.8	-0.6	-0.5	-0.9	-0.5	0.9
Time to tail flick, test, after self-admin	0.3	0.3	1.3	-0.3	-1.1	-0.1	-0.3	0.4	0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	-0.0	0.1	0.6	-0.3	-0.8	0.4
Delta time to tail flick, test, before/after SA	0.3	0.3	1.0	0.3	-1.0	-0.3	-0.6	-0.3	0.5
Ambulatory time before self-admin	1.0	1.1	2.5	0.3	-1.6	-0.9	-1.2	-0.4	1.2
Ambulatory time after self-admin	0.2	0.2	0.8	-0.3	-0.9	-0.3	-0.2	0.4	0.1
Total heroin consumption	1.3	1.5	2.4	1.5	-0.0	0.0	-1.4	-1.5	1.6
Area under the delay curve	1.4	1.5	2.2	1.4	-1.1	-1.5	-1.2	-1.1	1.1
Delay disc. indifference point, 0s delay	0.9	1.0	1.6	-1.2	0.6	0.1	1.1	1.0	-1.3
Delay disc. indifference point, 16s delay	1.8	1.8	2.8	1.5	-0.7	-1.3	-1.4	-1.7	1.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.0	-0.0	-0.3	0.4	0.3	-0.5
Delay disc. indifference point, 24s delay	5.6	5.5	7.1	2.4	-1.7	-2.1	-2.5	-2.7	2.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.5	0.0	-0.2	-0.1	-0.4	0.0
Delay disc. indifference point, 8s delay	2.1	2.2	3.1	1.5	-1.3	-1.8	-1.5	-1.3	1.4
Delay discount exponential model param	2.2	2.3	3.1	-1.7	1.3	1.8	1.5	1.4	-1.4
Delay discount hyperbolic model param	1.6	1.7	2.4	-1.6	1.1	1.5	1.3	1.1	-1.1
Fecal boli incidents, locomotor time 1	0.7	0.7	2.2	1.1	0.5	-1.5	-0.5	-0.5	0.5
Change in fecal boli incidents, locomotor task	3.1	2.9	4.9	-2.2	-0.4	0.9	1.8	2.1	-2.0
Time >=10cm from walls, locomotor time 1	1.0	1.0	2.0	-0.6	0.6	-0.9	1.0	1.2	-1.4
Bouts of movement, locomotor time 1	3.9	4.3	5.2	2.2	-1.8	-2.3	-2.1	-1.9	2.1
Total resting periods, locomotor time 1	3.5	3.9	5.5	2.1	-1.6	-2.3	-1.9	-1.8	1.9
Rest time, locomotor task time 1	0.2	0.2	1.0	0.6	-0.1	-1.0	-0.2	-0.3	0.2
Distance moved, locomotor task time 1	0.6	0.7	1.6	-0.8	0.8	1.3	0.8	0.5	-0.8
Vertical activity count, locomotor time 1	0.8	0.8	1.1	-1.1	0.6	0.9	0.9	0.9	-0.9
Time >=10cm from walls, locomotor time 2	1.4	1.5	2.4	-0.7	1.6	1.0	1.2	1.4	-1.4
Bouts of movement, locomotor time 2	0.4	0.5	1.3	-0.4	-0.3	-1.1	0.5	0.7	-0.7
Total resting periods, locomotor time 2	0.3	0.4	1.4	-0.2	-0.5	-1.2	0.2	0.5	-0.4
Rest time, locomotor task time 2	1.0	1.2	2.2	1.5	-0.6	-1.0	-1.2	-0.9	1.2
Distance moved, locomotor task time 2	1.1	1.2	3.3	-1.2	0.9	1.8	0.9	0.5	-0.8
Vertical activity count, locomotor time 2	2.4	2.7	3.7	-1.7	1.9	1.9	1.5	1.2	-1.5
Weight adjusted by age	0.1	0.1	0.2	-0.4	-0.4	0.2	0.3	0.3	-0.4
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	2.0	-0.6	0.3	1.4	0.3	0.5	-0.2
Locomotion in novel chamber	1.6	1.9	2.9	-1.3	1.4	1.7	1.3	1.4	-1.2
Locomotion in novel chamber post-restriction	1.4	1.7	3.2	-1.0	0.8	0.5	1.5	1.8	-1.6
Progressive ratio	1.0	1.2	3.3	-1.0	0.5	1.8	0.9	1.0	-0.8
Food seeking constrained by brief footshock	1.2	1.5	3.3	1.8	-0.5	-0.6	-1.3	-1.4	1.2
Seeking ratio, punishment vs. effort	1.3	1.6	4.2	1.4	-0.5	-2.0	-1.0	-1.1	0.8
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.3	-0.0	0.2	0.1	0.3	-0.2
Run reversals in cocaine runway, males	0.5	0.5	1.2	0.6	-1.1	-0.9	-0.5	-0.4	0.4
Latency to leave start box in cocaine runway	0.4	0.4	0.9	0.7	-0.0	-0.1	-0.7	-1.0	0.8
Latency to leave start box in cocaine runway, F	1.3	1.5	2.1	1.1	-1.1	-1.0	-1.3	-1.4	1.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.8	-0.2	0.9	0.6	0.3	0.2	-0.2
Cd content in liver	0.2	0.2	0.3	0.4	0.5	-0.6	0.1	0.4	-0.2
Co content in liver	6.9	8.1	14.1	3.0	-2.5	-3.8	-2.7	-2.4	2.5
Cu content in liver	1.3	1.5	2.6	1.6	-0.7	-1.6	-1.1	-1.0	1.1
Fe content in liver	0.4	0.5	1.7	0.3	1.3	0.9	0.3	0.2	-0.2
K content in liver	0.2	0.2	0.4	-0.2	-0.3	0.3	-0.4	-0.5	0.6
Mg content in liver	0.8	0.9	2.1	0.5	-0.1	0.6	-1.0	-1.4	1.3
Mn content in liver	0.2	0.3	0.5	0.2	-0.4	0.1	-0.6	-0.6	0.7
Na content in liver	0.9	0.9	1.6	1.2	-0.4	0.2	-1.0	-1.1	1.3
Rb content in liver	0.4	0.6	1.6	0.4	-0.5	-0.1	-0.8	-1.3	0.9
Se content in liver	0.2	0.2	1.1	-0.5	0.1	1.0	-0.1	-0.1	0.2
Sr content in liver	0.2	0.2	0.6	-0.2	-0.7	-0.2	0.3	0.7	-0.3
Zn content in liver	0.2	0.2	0.8	0.3	-0.9	0.1	-0.4	-0.3	0.5