Hub : Genes

Snx11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000008642	0.06	0.06	4.2e-05	0.05	0.04	0.04	0.04	5.8e-06	9.1e-05	4.3e-05	8.1e-06
2	Liver	intron excision ratio	chr10:81749679:81752622	0.02	0.03	8.8e-03	0.02	0.01	0.01	0.01	2.8e-03	2.8e-02	3.0e-02	2.0e-02
3	OFC	isoform ratio	ENSRNOT00000011474	0.25	0.2	9.8e-03	0.07	0.04	0.05	0.05	8.1e-03	5.3e-02	2.8e-02	2.2e-02
4	OFC	isoform ratio	ENSRNOT00000089146	0.15	0.12	6.8e-03	0.04	0.05	0.02	0.04	3.4e-02	3.0e-02	1.3e-01	3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	11.1	36.0	44.2	-6.2	6.6	4.3	-6.6
BMI without tail	0.9	1.9	2.8	-1.7	1.6	0.3	-1.5
Body weight	0.6	2.4	4.8	-1.4	1.6	-2.2	-0.7
Epididymis fat weight	0.1	0.2	0.6	0.2	0.1	-0.8	0.1
Glucose	0.4	0.6	0.8	-0.8	0.9	-0.5	-0.7
Heart weight	1.1	1.6	2.8	-1.5	1.7	0.0	-1.2
Left kidney weight	0.9	2.7	9.9	0.0	-0.1	-3.1	0.9
Right kidney weight	0.4	1.2	2.7	-0.9	1.1	-1.6	-0.4
Tail length	13.4	40.5	50.6	5.5	-5.9	-7.1	6.8
Length with tail	9.9	36.2	57.8	4.9	-5.0	-7.6	6.2
Length without tail	0.8	1.7	4.7	0.9	-0.5	-2.2	1.0
Liver weight, left	0.7	1.2	1.5	1.2	-0.9	-1.0	1.2
Liver weight, right	1.9	3.1	6.4	1.5	-0.9	-2.5	1.7
Parametrial fat weight	0.0	0.0	0.1	-0.1	0.1	0.3	-0.1
Retroperitoneal fat weight	0.3	1.0	1.9	-0.9	1.4	-0.9	-0.6
Intraocular pressure	1.7	2.4	3.2	1.4	-1.4	-1.8	1.6
Extensor digitorum longus weight	0.2	0.7	2.2	-0.4	0.5	-1.5	-0.3
Soleus weight	0.8	2.5	3.2	-1.7	1.8	0.8	-1.7
Tibialis anterior weight	0.4	1.2	1.8	1.0	-1.1	-1.3	1.0
Tibia length	0.3	0.7	0.9	-0.9	0.9	-0.8	-0.7
Number of licking bursts	0.1	0.1	0.2	0.2	-0.4	0.3	0.2
Food consumed during 24 hour testing period	1.3	1.6	2.1	1.3	-1.4	-0.9	1.3
Times rat made contact with spout	0.1	0.1	0.1	0.1	-0.4	0.4	0.1
Mean time between licks in bursts	0.1	0.1	0.2	-0.3	0.2	0.0	-0.4
Mean num. licks in bursts	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2
Std. dev. time between licks in bursts	1.1	1.3	1.5	-1.2	1.2	1.0	-1.1
Water consumed over 24 hours	0.1	0.2	0.4	0.4	-0.7	0.0	0.3
Indifference point 0 sec	0.7	1.2	2.1	-1.4	1.1	0.7	-1.1
Indifference point AUC	0.1	0.1	0.2	0.5	-0.3	0.2	0.3
Indifference point function ln k	0.0	0.1	0.2	0.1	-0.2	-0.4	0.1
Indifference point function log k	0.0	0.1	0.2	0.1	-0.2	-0.4	0.1
Delay discounting total patch changes 0 sec	0.7	1.2	2.1	-1.4	1.1	0.4	-1.0
Delay discounting total patch changes 12 sec	0.3	0.4	0.9	-0.5	0.3	1.0	-0.5
Delay discounting total patch changes 18 sec	1.6	2.1	2.5	-1.4	1.4	1.6	-1.5
Delay discounting total patch changes 24 sec	1.6	2.0	2.9	-1.7	1.6	1.0	-1.3
Delay discounting total patch changes 6 sec	0.8	1.3	1.5	-1.1	0.9	1.2	-1.2
Delay discounting time to switch 0 sec	0.1	0.2	0.3	-0.3	0.2	0.6	-0.4
Delay discounting water rate 0 sec	0.5	0.8	1.4	-1.1	1.2	-0.4	-0.8
Delay discounting water rate 12 sec	0.3	0.5	1.6	0.4	-0.2	-1.3	0.4
Delay discounting water rate 18 sec	0.6	0.8	1.7	0.7	-0.6	-1.3	0.9
Delay discounting water rate 24 sec	0.5	0.7	1.0	-0.9	1.0	0.3	-0.9
Delay discounting water rate 6 sec	0.0	0.0	0.0	0.1	0.2	0.1	0.1
Locomotor activity	0.9	1.5	2.5	-1.0	1.0	1.6	-1.1
Locomotor testing distance	2.0	3.3	6.8	-1.4	1.3	2.6	-1.7
Locomotor testing rearing	0.6	0.9	3.1	-0.2	0.4	1.8	-0.6
Light reinforcement 1	0.9	1.6	4.1	-0.9	0.6	2.0	-1.0
Light reinforcement 2	0.1	0.1	0.3	-0.2	0.2	0.5	-0.2
Reaction time number correct	0.1	0.1	0.1	0.3	-0.1	-0.4	0.2
Reaction time mean minus median	0.6	0.8	1.5	1.0	-1.2	0.5	0.6
Reaction time mean minus median AUC	0.8	1.0	1.9	1.1	-1.4	0.8	0.6
Reaction time num false alarms	0.2	0.2	0.4	0.4	-0.6	0.2	0.5
Reaction time num false alarms AUC	0.2	0.3	0.5	0.4	-0.7	-0.0	0.7
Reaction time trials correct on left	0.1	0.1	0.1	0.3	-0.1	-0.4	0.2
Reaction time trials on left	0.1	0.1	0.1	0.3	-0.2	-0.4	0.3
Reaction time mean	0.3	0.5	1.6	0.2	-0.5	1.3	-0.2
Reaction time mean AUC	0.3	0.4	1.3	0.2	-0.6	1.2	-0.2
Median of all reaction times	0.6	0.8	2.5	-0.3	0.1	1.6	-0.6
Reaction time omissions	0.1	0.2	0.4	0.3	-0.6	0.3	0.2
Reaction time false alarm rate	0.1	0.1	0.2	0.1	-0.4	0.2	0.3
Reaction time premature initiation rate	0.4	0.6	1.1	0.7	-1.0	-0.6	0.7
Reaction time premature initiations	0.7	1.0	1.4	0.9	-1.2	-0.8	0.9
Std. dev. reaction times	0.4	0.5	1.1	0.7	-1.0	0.4	0.5
Reaction time trials completed	0.1	0.1	0.1	0.3	-0.2	-0.4	0.3
Reaction time trials AUC	0.1	0.1	0.1	0.3	-0.2	-0.3	0.3
Social response proportion	1.3	1.4	2.4	0.8	-0.9	-1.5	1.3
Social responses	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.3
Social time	0.3	0.4	1.3	-0.1	-0.3	1.1	-0.2
Conditioned locomotion	0.7	0.9	1.1	-1.0	1.1	0.3	-1.1
Cocaine response after cond. corrected	4.4	5.0	6.6	-2.6	2.4	1.2	-2.4
Cocaine response after cond. not corrected	2.2	2.5	3.7	-1.9	1.8	0.5	-1.7
Cocaine response before conditioning	2.1	2.6	3.2	1.7	-1.6	-1.2	1.8
Saline control response	0.1	0.1	0.2	0.4	-0.3	0.1	0.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	0.4	0.6	-0.4
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.5	-0.8	0.6	1.2	-0.8
Condit. Reinf. active responses	0.0	0.1	0.2	-0.1	0.1	0.4	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.5	-0.4	0.1	0.4
Condit. Reinf. lever presses	0.6	0.8	1.2	0.8	-1.1	-0.7	0.9
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.1	-0.2	0.3	0.1
Pavlov. Cond. lever latency	0.6	0.8	1.0	1.0	-0.9	-0.7	1.0
Pavlov. Cond. magazine entry latency	0.7	0.8	1.6	0.5	-0.9	-1.3	0.9
Pavlov. Cond. change in total contacts	0.2	0.3	0.5	-0.7	0.4	0.4	-0.5
Pavlov. Cond. index score	0.2	0.2	0.6	-0.8	0.4	-0.1	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.5	0.2	-0.4	-0.2
Pavlov. Cond. lever contacts	0.5	0.7	0.9	-1.0	0.8	0.6	-0.9
Pavlov. Cond. magazine entry number	0.1	0.2	0.5	0.2	0.2	0.7	-0.1
Pavlov. Cond. intertrial magazine entries	1.4	1.8	3.1	1.8	-1.3	-0.7	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	-0.9	0.5	-0.2	-0.5
Pavlov. Cond. response bias	0.4	0.6	0.9	-1.0	0.7	0.4	-0.8
Conditioned reinforcement - actives	1.4	1.4	2.2	-1.1	1.0	1.5	-1.1
Conditioned reinforcement - inactives	0.2	0.2	0.4	0.6	-0.2	0.6	0.4
Conditioned locomotion	3.9	4.7	6.4	-2.5	2.0	2.0	-2.1
Intermittent access intake day 1-15 change	2.3	2.3	4.0	-1.6	2.0	0.8	-1.4
Intermittent access intake escalation	2.3	2.2	3.7	-1.6	1.9	0.9	-1.4
Intermittent access intake escalation 2	1.7	1.6	3.1	-1.2	1.7	0.7	-1.2
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.4	0.6	-0.3	0.3	0.2
Intermitt. access day 15 inactive lever presses	1.3	1.5	3.9	-0.6	0.8	2.0	-1.0
Intermitt. access escalation Index	1.3	1.1	2.1	-1.4	1.1	0.5	-1.0
Intermittent access day 1 total infusions	0.4	0.5	1.1	0.9	-1.0	-0.1	0.5
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.3	0.4	0.5	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.6	-0.2	0.4	0.8	-0.5
Intermittent access total infusions	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0
Intermittent access day 1 locomotion	0.2	0.2	0.5	0.4	-0.7	-0.1	0.4
Intermittent access day 15 total locomotion	0.3	0.3	0.4	-0.6	0.6	0.6	-0.5
Intermittent access total locomotion	0.5	0.5	0.7	-0.8	0.7	0.7	-0.7
Intermittent access standard deviation	2.0	2.1	4.2	-1.4	2.0	0.7	-1.2
Cocaine induced anxiety	0.1	0.1	0.1	-0.4	0.3	-0.1	-0.2
Post-drug Anxiety	0.3	0.3	0.5	0.7	-0.7	0.5	0.5
Baseline Anxiety	0.6	0.6	2.4	0.3	-0.1	1.6	-0.3
Lifetime Intake	0.0	0.0	0.1	0.3	-0.3	0.0	0.1
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.2	0.5	0.6	-0.3
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	-0.4	0.7	0.6	-0.5
Progressive ratio test 1 active lever presses	0.3	0.3	0.7	0.5	-0.8	-0.5	0.4
Progressive ratio test 1 breakpoint	0.6	0.6	1.1	0.7	-1.0	-0.7	0.6
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.1	0.0	0.4	-0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.4	-0.4	0.3	0.2
Progressive ratio test 2 breakpoint	0.0	0.1	0.1	0.2	-0.2	0.3	0.0
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.4	-0.1	0.4	0.1
Total sessions with >9 infusions	0.1	0.1	0.2	-0.4	0.4	0.3	-0.4
Short access day 1 total inactive lever presses	2.0	2.2	3.7	1.9	-1.7	-0.2	1.6
Short access day 10 total inactive lever presses	0.3	0.4	1.0	1.0	-0.5	0.1	0.5
Short access day 1 total infusions	0.1	0.1	0.1	0.3	-0.2	0.4	0.1
Short access day 10 total infusions	0.1	0.2	0.2	-0.4	0.4	0.3	-0.5
Short access total infusions	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.1
Short access day 1 locomotion	0.8	0.8	1.1	-1.0	1.1	0.7	-0.8
Short access day 10 total locomotion	0.5	0.5	1.1	-1.1	0.9	0.3	-0.4
Short access total locomotion	0.8	0.8	1.4	-1.2	1.2	0.3	-0.7
Compulsive drug intake	7.0	7.0	9.0	2.9	-3.0	-1.8	2.7
One hour access (0.3 mA shock)	0.4	0.5	0.8	0.9	-0.9	-0.1	0.7
One hour access (shock baseline)	2.5	2.9	3.4	-1.7	1.9	1.5	-1.7
Number of responses in last shaping day	0.1	0.1	0.2	-0.1	0.0	0.5	-0.5
Context. condit. distance diff. score	0.1	0.2	0.3	-0.4	0.4	0.2	-0.5
Locomotion velocity, session 1	0.4	0.4	0.6	-0.8	0.7	0.5	-0.6
Locomotion distance, session 1	2.7	3.5	4.3	1.6	-1.7	-2.1	2.0
Locomotion velocity, session 2	1.4	1.7	3.2	0.9	-1.0	-1.8	1.3
Locomotion distance, session 2	3.1	4.5	5.4	1.9	-1.9	-2.3	2.3
Locomotion velocity, session 3	0.1	0.1	0.3	0.1	-0.0	-0.6	0.2
Locomotion distance, session 3	3.6	3.9	4.6	2.0	-1.8	-2.1	2.0
Stereotopy head waving bouts, day 3	4.4	5.2	5.7	-2.4	2.4	2.0	-2.4
Stereotopy head waving duration, day 3	3.0	3.6	4.5	-2.1	2.1	1.4	-2.0
Locomotion velocity, session 7	1.5	1.7	2.1	1.2	-1.2	-1.4	1.3
Locomotion distance, session 7	5.4	6.8	7.5	2.6	-2.5	-2.6	2.7
Stereotopy head waving bouts, day 7	0.9	1.0	1.6	-0.9	0.9	1.3	-0.9
Stereotopy head waving duration, day 7	0.5	0.6	1.2	-0.7	0.6	1.1	-0.7
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.3
Locomotion distance, session 8	0.8	1.3	2.1	0.9	-1.0	-1.4	1.1
Degree of sensitization distance	0.0	0.0	0.1	-0.0	-0.0	-0.3	0.1
Degree of sensitization stereotypy	0.3	0.3	1.1	0.2	-0.2	1.0	-0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.4	-0.3	0.1	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	-0.5	0.5	0.7	-0.5
Condit. Reinf. active responses	0.1	0.1	0.1	0.4	-0.2	0.4	0.2
Condit. Reinf. inactive responses	0.3	0.3	0.7	0.8	-0.6	0.1	0.5
Incentive salience index mean	0.2	0.2	0.3	0.5	-0.6	0.1	0.6
Condit. Reinf. lever presses	0.5	0.7	1.2	0.9	-1.1	0.1	0.9
Time in familiar zone, hab. session 1	0.5	0.5	0.8	0.9	-0.8	0.7	0.3
Time in novel zone, hab. session 1	2.7	2.6	3.5	-1.9	1.8	1.0	-1.7
Total zone transitions, hab. session 1	5.8	8.2	9.2	3.0	-3.0	-2.3	3.0
Total locomotion distance, hab. session 1	2.2	3.2	4.1	2.0	-1.9	-1.2	1.9
Locomotion velocity, hab. session 1	3.3	4.8	5.4	2.3	-2.2	-1.9	2.3
Time in familiar zone, hab. session 2	0.7	0.8	1.6	-0.6	0.6	1.2	-0.9
Time in novel zone, hab. session 2	0.2	0.2	0.5	0.2	-0.2	-0.7	0.4
Total zone transitions, hab. session 2	1.5	1.9	2.4	1.5	-1.5	-0.8	1.5
Total locomotion distance, hab. session 2	0.0	0.0	0.0	0.1	-0.0	-0.1	0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.2	-0.1	-0.5	0.4
Novel to familiar place preference ratio	1.5	1.6	2.8	1.1	-1.0	-1.7	1.1
Novelty place preference	1.6	1.7	2.7	1.2	-1.1	-1.6	1.2
Time in novel zone, NPP test	1.2	1.2	1.8	1.1	-1.0	-1.3	1.0
Total zone transitions, NPP test	2.9	4.2	5.3	2.1	-2.2	-1.6	2.3
Total locomotion distance, NPP test	0.6	0.9	1.1	1.0	-0.9	-0.7	1.1
Locomotion velocity, NPP test	1.2	1.8	2.2	1.3	-1.2	-1.3	1.5
Pavlov. Cond. lever latency	0.8	1.0	1.6	-1.2	1.3	-0.1	-1.0
Pavlov. Cond. magazine entry latency	0.2	0.3	1.1	0.0	-0.1	1.0	-0.1
Pavlov. Cond. change in total contacts	1.6	1.7	2.6	1.6	-1.6	0.2	1.3
Pavlov. Cond. index score	0.4	0.5	0.8	0.6	-0.8	0.9	0.5
Pavlov. Cond. latency score	0.4	0.5	0.8	0.7	-0.9	0.6	0.6
Pavlov. Cond. lever contacts	1.2	1.4	2.3	1.3	-1.5	0.1	1.2
Pavlov. Cond. magazine entry number	0.5	0.7	2.3	-0.5	0.5	-1.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.0	1.0	-0.7	-1.0	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	0.6	-0.8	0.9	0.4
Pavlov. Cond. response bias	0.5	0.6	1.1	0.8	-0.8	1.1	0.4
Bone: apparent density	1.4	2.3	3.1	-1.4	1.8	1.3	-1.6
Bone surface	0.3	0.5	1.1	-0.6	1.1	-0.0	-0.6
Bone volume	0.9	1.6	2.8	-1.3	1.7	0.6	-1.3
Bone: connectivity density	0.2	0.3	0.7	-0.1	0.6	0.8	-0.5
Bone: cortical apparent density	4.8	6.3	10.4	3.0	-3.2	-0.4	2.4
Bone: cortical area	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.1
Bone: cortical porosity	0.4	0.5	0.5	-0.7	0.7	0.6	-0.7
Bone: cortical porosity	0.3	0.3	0.4	-0.6	0.7	0.3	-0.5
Bone: cortical thickness	0.2	0.3	0.5	0.5	-0.5	-0.7	0.5
Bone: cortical thickness	1.3	1.5	1.9	1.1	-1.1	-1.3	1.4
Bone: cortical tissue density	5.1	6.6	10.9	3.1	-3.3	-0.5	2.5
Bone: elastic displacement	0.1	0.1	0.3	-0.5	0.4	0.1	-0.3
Bone: elastic work	0.1	0.1	0.5	-0.1	0.0	-0.7	0.1
Bone: endosteal estimation	0.2	0.5	1.1	-0.7	1.0	-0.6	-0.4
Bone: endosteal perimeter	0.4	0.7	1.7	-0.9	1.3	-0.1	-0.7
Bone: final force	0.2	0.3	0.5	-0.5	0.7	0.2	-0.5
Bone: final moment	0.2	0.3	0.6	-0.6	0.8	0.1	-0.5
Bone: marrow area	0.2	0.4	0.8	-0.5	0.9	-0.6	-0.3
Bone: maximum diameter	0.4	0.7	1.5	-0.8	1.2	0.4	-0.8
Bone: maximum force	0.4	0.6	1.3	-0.8	1.1	-0.2	-0.7
Bone: maximum moment	0.4	0.7	1.3	-0.9	1.1	-0.4	-0.7
Bone: minimum diameter	0.1	0.2	0.8	-0.2	0.4	-0.9	0.1
Bone: periosteal estimation	0.3	0.6	1.4	-0.7	1.2	-0.2	-0.6
Bone: periosteal perimeter	0.3	0.5	1.1	-0.7	1.1	-0.3	-0.6
Bone: post-yield work	0.1	0.1	0.2	-0.2	0.5	-0.4	-0.3
Bone: stiffness	0.0	0.1	0.2	-0.0	0.4	-0.3	-0.1
Bone: tissue strength	0.1	0.1	0.2	-0.2	0.2	0.2	-0.4
Bone: trabecular number	1.0	1.5	2.6	-0.8	1.2	1.6	-1.2
Bone: trabecular spacing	0.0	0.0	0.1	-0.1	-0.2	0.2	0.0
Bone: trabecular thickness	1.0	1.2	2.1	-1.2	1.4	0.0	-1.2
Bone: trabecular tissue density	0.1	0.1	0.1	0.2	-0.4	-0.3	0.3
Breakpoint value in progressive ratio session	3.9	4.4	5.0	2.1	-2.1	-1.9	2.2
Distance traveled before self-admin	0.6	0.6	0.9	0.7	-0.6	-0.9	0.9
Distance traveled after self-admin	0.6	0.7	1.0	-1.0	1.0	0.1	-0.8
Delta time in closed arm before/after self-admin	0.2	0.1	0.3	0.4	-0.4	-0.5	0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.3	-0.4	0.3	0.2
Diff in mean of infusions in LGA sessions	0.4	0.5	1.1	1.0	-0.6	0.1	0.6
Extinction: sum of active levers before priming	1.3	1.3	1.5	1.0	-1.2	-1.2	1.2
Active lever presses in extinction session 6	0.2	0.2	0.3	-0.4	0.6	0.2	-0.3
Delta distance traveled before/after self-admin	1.8	1.9	2.7	-1.4	1.3	1.1	-1.7
Delta ambulatory time before/after self-admin	2.1	2.3	3.1	-1.6	1.5	1.1	-1.8
Time in closed arm before self-admin	1.3	1.5	1.9	-1.3	1.4	1.0	-1.2
Time in closed arm after self-admin	0.5	0.5	0.8	-0.8	0.9	0.1	-0.9
Time in open arm before self-admin	0.4	0.4	0.8	0.8	-0.9	-0.3	0.4
Time in open arm after self-admin	0.5	0.5	1.0	0.9	-1.0	0.4	0.4
Sum of active levers in priming session hrs 5-6	2.9	2.8	3.8	1.7	-1.8	-1.1	1.9
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.2	1.3	-1.5	-0.3	1.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.3	-0.2	0.4	0.5	-0.5
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.5	0.2	0.1	-0.2
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.1	-0.0	-0.3	-0.2
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	1.7	-1.1	1.3	0.7	-1.3
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	0.6	-0.5	-0.8	0.6
Ambulatory time before self-admin	0.4	0.4	0.5	0.5	-0.5	-0.7	0.7
Ambulatory time after self-admin	0.9	0.9	1.6	-1.3	1.1	-0.2	-0.9
Total heroin consumption	1.2	1.5	2.4	1.6	-1.5	-0.2	1.1
Area under the delay curve	0.5	0.6	1.3	0.6	-0.3	-1.1	0.7
Delay disc. indifference point, 0s delay	0.8	0.9	1.2	1.1	-0.9	-0.7	1.0
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.5	0.6	-0.4	-0.3
Delay disc. indifference point, 2s delay	0.4	0.4	1.0	0.4	-0.2	-1.0	0.6
Delay disc. indifference point, 24s delay	0.6	0.6	0.9	0.7	-0.6	-1.0	0.8
Delay disc. indifference point, 4s delay	4.6	4.8	7.5	2.0	-1.7	-2.7	2.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	0.4	-0.3	-0.5	0.4
Delay discount exponential model param	0.8	0.8	2.0	-0.6	0.4	1.4	-0.8
Delay discount hyperbolic model param	1.1	1.1	2.4	-0.8	0.6	1.5	-1.0
Fecal boli incidents, locomotor time 1	2.7	3.0	3.8	-1.8	2.0	1.3	-1.8
Change in fecal boli incidents, locomotor task	2.6	2.4	3.2	1.6	-1.8	-1.3	1.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	0.5	-0.6	0.4	0.2
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.2	0.2	-0.3	-0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.3	0.4	-0.5	-0.3
Rest time, locomotor task time 1	0.2	0.2	0.4	-0.4	0.6	-0.3	-0.3
Distance moved, locomotor task time 1	1.0	1.1	1.6	1.0	-1.3	-0.7	1.1
Vertical activity count, locomotor time 1	0.3	0.3	0.8	0.4	-0.9	-0.2	0.5
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.9	0.8	-0.9	-0.2	0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.3	0.4	0.5	-0.4
Total resting periods, locomotor time 2	0.2	0.2	0.3	-0.3	0.4	0.6	-0.4
Rest time, locomotor task time 2	0.7	0.8	1.4	1.2	-1.1	-0.1	0.8
Distance moved, locomotor task time 2	0.7	0.8	2.4	0.1	-0.5	-1.6	0.6
Vertical activity count, locomotor time 2	0.4	0.4	1.5	-0.4	-0.1	-1.2	0.2
Weight adjusted by age	0.7	0.8	1.3	0.8	-1.1	-0.6	0.9
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.6	-0.3	0.6	0.8	-0.8
Locomotion in novel chamber	0.6	0.7	1.0	1.0	-1.0	-0.6	0.7
Locomotion in novel chamber post-restriction	2.0	2.3	3.3	-1.3	1.3	1.8	-1.7
Progressive ratio	0.1	0.1	0.2	0.2	0.1	-0.5	0.3
Food seeking constrained by brief footshock	0.5	0.6	1.2	-0.7	1.1	0.6	-0.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.2	-0.1	0.4	-0.3
Run reversals in cocaine runway, females	0.6	0.6	1.6	0.4	-0.5	-1.3	0.7
Run reversals in cocaine runway, males	2.4	2.3	5.5	-0.9	0.8	2.4	-1.4
Latency to leave start box in cocaine runway	2.3	2.5	4.0	-1.5	2.0	0.8	-1.7
Latency to leave start box in cocaine runway, F	3.3	3.6	5.5	-1.9	2.4	0.8	-2.2
Latency to leave start box in cocaine runway, M	0.6	0.6	1.0	-0.7	1.0	0.5	-0.7
Cd content in liver	0.4	0.5	0.8	0.9	-0.8	-0.3	0.6
Co content in liver	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.1
Cu content in liver	1.6	2.0	3.0	1.7	-1.5	-0.6	1.6
Fe content in liver	1.7	2.0	3.1	1.3	-1.1	-1.8	1.5
K content in liver	0.1	0.1	0.3	-0.4	0.5	0.0	-0.2
Mg content in liver	0.5	0.5	0.9	0.9	-0.7	-0.2	0.8
Mn content in liver	1.6	1.8	2.6	1.5	-1.6	0.0	1.5
Na content in liver	1.1	1.2	1.6	-1.1	1.0	1.3	-0.9
Rb content in liver	0.3	0.4	1.2	0.5	-0.0	1.1	-0.2
Se content in liver	0.2	0.2	0.5	-0.4	0.7	0.3	-0.5
Sr content in liver	2.3	2.1	2.4	1.1	-1.6	-1.6	1.5
Zn content in liver	0.2	0.2	0.7	-0.2	0.2	0.8	-0.3