Hub : Genes

Hoxb4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000008191 0.12 0.08 4.8e-06 0.04 0.04 0.04 0.05 8.7e-06 1.8e-05 1.6e-05 6.6e-06
2 Liver gene expression ENSRNOG00000008191 0.02 0.01 6.8e-03 0.01 0.01 0.01 0 6.8e-03 4.2e-02 1.1e-02 1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
BMI with tail13.142.342.5-6.56.5
BMI without tail1.22.62.6-1.61.6
Body weight0.52.32.4-1.61.5
Epididymis fat weight0.00.00.0-0.10.1
Glucose0.60.80.9-0.90.9
Heart weight2.33.33.4-1.81.9
Left kidney weight0.00.00.00.10.0
Right kidney weight0.41.01.1-1.01.0
Tail length11.534.934.95.9-5.9
Length with tail6.824.824.95.0-5.0
Length without tail0.10.30.30.5-0.6
Liver weight, left0.60.90.90.9-1.0
Liver weight, right0.71.11.21.0-1.1
Parametrial fat weight0.00.00.0-0.10.2
Retroperitoneal fat weight0.61.91.9-1.41.4
Intraocular pressure1.52.12.11.5-1.4
Extensor digitorum longus weight0.10.30.3-0.50.5
Soleus weight1.13.33.3-1.81.8
Tibialis anterior weight0.31.21.21.1-1.1
Tibia length0.20.70.7-0.80.8
Number of licking bursts0.10.20.20.4-0.4
Food consumed during 24 hour testing period1.72.02.11.4-1.4
Times rat made contact with spout0.10.10.10.3-0.4
Mean time between licks in bursts0.00.10.1-0.20.3
Mean num. licks in bursts0.00.00.00.1-0.2
Std. dev. time between licks in bursts1.31.51.5-1.21.2
Water consumed over 24 hours0.40.40.40.7-0.7
Indifference point 0 sec0.81.31.5-1.11.2
Indifference point AUC0.10.10.10.3-0.3
Indifference point function ln k0.00.00.00.2-0.2
Indifference point function log k0.00.00.00.2-0.2
Delay discounting total patch changes 0 sec0.91.41.5-1.21.2
Delay discounting total patch changes 12 sec0.10.20.2-0.40.4
Delay discounting total patch changes 18 sec1.72.22.3-1.41.5
Delay discounting total patch changes 24 sec2.12.72.8-1.61.7
Delay discounting total patch changes 6 sec0.71.01.1-1.01.0
Delay discounting time to switch 0 sec0.00.10.1-0.20.3
Delay discounting water rate 0 sec0.81.21.3-1.11.1
Delay discounting water rate 12 sec0.10.10.10.3-0.4
Delay discounting water rate 18 sec0.30.40.50.7-0.7
Delay discounting water rate 24 sec0.60.80.9-0.90.9
Delay discounting water rate 6 sec0.00.00.0-0.10.0
Locomotor activity0.50.80.8-0.90.9
Locomotor testing distance0.91.51.5-1.21.2
Locomotor testing rearing0.10.10.2-0.30.4
Light reinforcement 10.30.60.7-0.70.8
Light reinforcement 20.00.00.0-0.10.1
Reaction time number correct0.00.00.00.1-0.1
Reaction time mean minus median1.11.41.61.3-1.1
Reaction time mean minus median AUC1.41.82.01.4-1.3
Reaction time num false alarms0.30.40.40.6-0.7
Reaction time num false alarms AUC0.40.50.50.7-0.7
Reaction time trials correct on left0.00.00.00.1-0.1
Reaction time trials on left0.00.00.00.2-0.1
Reaction time mean0.20.20.30.5-0.4
Reaction time mean AUC0.30.40.40.6-0.6
Median of all reaction times0.00.00.0-0.00.1
Reaction time omissions0.20.30.40.6-0.5
Reaction time false alarm rate0.20.20.20.4-0.5
Reaction time premature initiation rate0.81.01.01.0-1.0
Reaction time premature initiations0.91.31.31.1-1.2
Std. dev. reaction times0.71.01.21.1-0.9
Reaction time trials completed0.00.00.00.2-0.1
Reaction time trials AUC0.00.00.00.2-0.1
Social response proportion0.70.70.80.9-0.8
Social responses0.10.10.10.3-0.2
Social time0.10.10.10.3-0.3
Conditioned locomotion0.91.11.1-1.11.1
Cocaine response after cond. corrected5.36.06.1-2.42.5
Cocaine response after cond. not corrected2.93.23.3-1.81.8
Cocaine response before conditioning2.22.72.71.6-1.6
Saline control response0.10.10.10.3-0.3
Condit. Reinf. active minus inactive responses0.10.20.2-0.40.4
Condit. Reinf. active-inactive response ratio0.40.40.4-0.60.6
Condit. Reinf. active responses0.00.00.0-0.10.1
Condit. Reinf. inactive responses0.10.20.20.4-0.4
Condit. Reinf. lever presses0.91.21.21.1-1.1
Condit. Reinf. lever reinforcers received0.00.00.00.2-0.1
Pavlov. Cond. lever latency0.60.90.90.9-0.9
Pavlov. Cond. magazine entry latency0.70.80.80.9-0.9
Pavlov. Cond. change in total contacts0.10.20.2-0.40.5
Pavlov. Cond. index score0.20.20.2-0.40.5
Pavlov. Cond. latency score0.10.10.1-0.20.3
Pavlov. Cond. lever contacts0.50.60.7-0.80.8
Pavlov. Cond. magazine entry number0.00.00.0-0.20.1
Pavlov. Cond. intertrial magazine entries1.41.81.91.3-1.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.3-0.50.5
Pavlov. Cond. response bias0.40.50.6-0.70.7
Conditioned reinforcement - actives0.80.80.8-0.90.9
Conditioned reinforcement - inactives0.10.10.10.3-0.4
Conditioned locomotion3.03.63.7-1.91.9
Intermittent access intake day 1-15 change3.23.23.7-1.91.7
Intermittent access intake escalation3.33.23.5-1.91.7
Intermittent access intake escalation 22.82.83.0-1.71.6
Intermitt. access day 1 inactive lever presses0.00.00.10.2-0.1
Intermitt. access day 15 inactive lever presses0.60.60.7-0.80.8
Intermitt. access escalation Index1.21.01.2-1.11.0
Intermittent access day 1 total infusions0.80.91.01.0-0.9
Intermittent access day 15 total infusions0.10.10.1-0.30.3
Intermittent access terminal intake (last 3 days)0.10.10.1-0.40.3
Intermittent access total infusions0.00.00.00.1-0.2
Intermittent access day 1 locomotion0.50.50.60.7-0.6
Intermittent access day 15 total locomotion0.30.30.4-0.60.6
Intermittent access total locomotion0.40.40.5-0.60.7
Intermittent access standard deviation3.43.63.8-2.01.9
Cocaine induced anxiety0.10.10.1-0.40.3
Post-drug Anxiety0.30.30.30.6-0.6
Baseline Anxiety0.00.00.00.00.0
Lifetime Intake0.10.10.10.3-0.4
Incentive Sensitization - Responses0.10.10.2-0.40.3
Incentive Sensitization - Breakpoint0.30.40.4-0.60.5
Progressive ratio test 1 active lever presses0.80.90.90.9-1.0
Progressive ratio test 1 breakpoint1.21.31.41.1-1.2
Progressive ratio test 1 inactive lever presses0.00.00.0-0.00.0
Progressive ratio test 2 active lever presses0.20.30.30.5-0.5
Progressive ratio test 2 breakpoint0.10.20.20.3-0.5
Progressive ratio test 2 inactive lever presses0.00.00.00.2-0.1
Total sessions with >9 infusions0.10.10.1-0.30.3
Short access day 1 total inactive lever presses2.32.62.81.7-1.6
Short access day 10 total inactive lever presses0.20.20.20.5-0.5
Short access day 1 total infusions0.00.00.00.1-0.2
Short access day 10 total infusions0.20.20.2-0.40.4
Short access total infusions0.00.00.00.1-0.1
Short access day 1 locomotion1.01.11.1-1.11.0
Short access day 10 total locomotion0.70.70.8-0.80.9
Short access total locomotion1.21.21.2-1.11.1
Compulsive drug intake9.39.29.63.0-3.1
One hour access (0.3 mA shock)0.91.01.20.9-1.1
One hour access (shock baseline)2.83.33.3-1.81.8
Number of responses in last shaping day0.00.00.00.0-0.1
Context. condit. distance diff. score0.10.20.2-0.40.4
Locomotion velocity, session 10.40.40.5-0.70.6
Locomotion distance, session 12.32.93.01.7-1.7
Locomotion velocity, session 20.80.90.91.0-0.9
Locomotion distance, session 22.73.83.91.9-2.0
Locomotion velocity, session 30.00.00.00.00.0
Locomotion distance, session 33.13.33.31.8-1.8
Stereotopy head waving bouts, day 34.65.55.6-2.42.4
Stereotopy head waving duration, day 33.54.24.2-2.12.1
Locomotion velocity, session 71.31.41.41.2-1.2
Locomotion distance, session 74.96.26.32.5-2.5
Stereotopy head waving bouts, day 70.70.80.8-0.90.9
Stereotopy head waving duration, day 70.30.40.4-0.60.6
Locomotion velocity, session 80.10.10.1-0.30.3
Locomotion distance, session 80.60.90.91.0-1.0
Degree of sensitization distance0.00.00.00.0-0.0
Degree of sensitization stereotypy0.00.00.00.2-0.1
Condit. Reinf. active minus inactive responses0.10.10.10.3-0.4
Condit. Reinf. active-inactive response ratio0.20.20.2-0.50.5
Condit. Reinf. active responses0.00.10.10.2-0.2
Condit. Reinf. inactive responses0.30.40.40.6-0.6
Incentive salience index mean0.30.40.40.6-0.6
Condit. Reinf. lever presses1.01.31.41.1-1.2
Time in familiar zone, hab. session 10.60.60.60.8-0.7
Time in novel zone, hab. session 13.33.23.2-1.81.8
Total zone transitions, hab. session 16.69.39.53.0-3.1
Total locomotion distance, hab. session 12.53.63.71.9-1.9
Locomotion velocity, hab. session 13.34.74.82.2-2.2
Time in familiar zone, hab. session 20.40.40.5-0.60.7
Time in novel zone, hab. session 20.10.10.10.2-0.3
Total zone transitions, hab. session 21.92.52.61.5-1.6
Total locomotion distance, hab. session 20.00.00.00.1-0.1
Locomotion velocity, hab. session 20.00.00.10.2-0.2
Novel to familiar place preference ratio1.01.01.11.0-1.0
Novelty place preference1.21.31.31.1-1.1
Time in novel zone, NPP test1.01.01.01.0-1.0
Total zone transitions, NPP test3.34.74.82.2-2.2
Total locomotion distance, NPP test0.60.90.90.9-1.0
Locomotion velocity, NPP test1.11.51.61.2-1.2
Pavlov. Cond. lever latency1.31.71.7-1.31.3
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.2
Pavlov. Cond. change in total contacts2.32.52.51.6-1.6
Pavlov. Cond. index score0.60.70.80.8-0.9
Pavlov. Cond. latency score0.70.80.90.9-0.9
Pavlov. Cond. lever contacts2.02.42.51.5-1.6
Pavlov. Cond. magazine entry number0.20.30.3-0.50.5
Pavlov. Cond. intertrial magazine entries0.40.40.50.7-0.6
Pavlov. Cond. lever-magazine prob. diff.0.60.70.70.8-0.9
Pavlov. Cond. response bias0.60.70.70.8-0.9
Bone: apparent density1.83.03.0-1.71.7
Bone surface0.61.01.0-1.01.0
Bone volume1.52.62.6-1.61.6
Bone: connectivity density0.20.30.3-0.50.5
Bone: cortical apparent density8.010.410.43.2-3.2
Bone: cortical area0.10.20.2-0.40.4
Bone: cortical porosity0.50.50.6-0.70.7
Bone: cortical porosity0.40.40.5-0.70.6
Bone: cortical thickness0.20.30.30.6-0.5
Bone: cortical thickness1.01.11.21.1-1.1
Bone: cortical tissue density8.411.011.03.3-3.3
Bone: elastic displacement0.10.10.1-0.30.3
Bone: elastic work0.00.00.00.0-0.0
Bone: endosteal estimation0.51.01.0-1.01.0
Bone: endosteal perimeter0.81.61.6-1.31.3
Bone: final force0.30.50.6-0.70.8
Bone: final moment0.40.70.7-0.80.9
Bone: marrow area0.30.70.7-0.90.8
Bone: maximum diameter0.81.41.4-1.21.2
Bone: maximum force0.71.21.2-1.11.1
Bone: maximum moment0.71.31.3-1.11.2
Bone: minimum diameter0.10.10.1-0.30.4
Bone: periosteal estimation0.61.21.3-1.11.1
Bone: periosteal perimeter0.61.11.1-1.01.0
Bone: post-yield work0.20.20.2-0.40.5
Bone: stiffness0.10.20.2-0.40.4
Bone: tissue strength0.00.00.0-0.20.1
Bone: trabecular number0.91.41.4-1.21.2
Bone: trabecular spacing0.00.10.10.2-0.2
Bone: trabecular thickness1.61.92.0-1.41.4
Bone: trabecular tissue density0.10.10.10.4-0.4
Breakpoint value in progressive ratio session4.04.54.62.1-2.1
Distance traveled before self-admin0.40.40.50.7-0.7
Distance traveled after self-admin0.70.80.8-0.90.9
Delta time in closed arm before/after self-admin0.20.20.20.4-0.4
Delta time in open arm before/after self-admin0.10.10.10.4-0.2
Diff in mean of infusions in LGA sessions0.30.30.40.6-0.5
Extinction: sum of active levers before priming1.61.61.61.3-1.3
Active lever presses in extinction session 60.20.20.2-0.40.4
Delta distance traveled before/after self-admin1.61.71.7-1.31.3
Delta ambulatory time before/after self-admin2.02.22.2-1.51.5
Time in closed arm before self-admin1.82.12.1-1.41.5
Time in closed arm after self-admin0.80.80.8-0.90.9
Time in open arm before self-admin0.91.01.01.0-1.0
Time in open arm after self-admin1.01.11.11.1-1.0
Sum of active levers in priming session hrs 5-63.73.63.71.9-1.9
Time to tail flick, vehicle, before self-admin2.02.12.11.4-1.4
Time to tail flick, vehicle, after self-admin0.20.30.3-0.50.5
Time to tail flick, test, before self-admin0.10.10.1-0.30.3
Time to tail flick, test, after self-admin0.00.00.0-0.1-0.0
Delta time to tail flick, vehicle, before/after SA1.81.81.8-1.31.3
Delta time to tail flick, test, before/after SA0.30.30.30.5-0.5
Ambulatory time before self-admin0.30.30.30.5-0.5
Ambulatory time after self-admin1.01.11.1-1.11.1
Total heroin consumption2.02.42.51.6-1.5
Area under the delay curve0.10.10.20.3-0.4
Delay disc. indifference point, 0s delay0.70.70.70.9-0.8
Delay disc. indifference point, 16s delay0.40.40.4-0.60.6
Delay disc. indifference point, 2s delay0.10.10.10.2-0.4
Delay disc. indifference point, 24s delay0.50.50.60.6-0.7
Delay disc. indifference point, 4s delay2.83.03.11.7-1.8
Delay disc. indifference point, 8s delay0.10.10.10.3-0.3
Delay discount exponential model param0.20.20.3-0.40.5
Delay discount hyperbolic model param0.40.50.5-0.60.7
Fecal boli incidents, locomotor time 13.63.93.9-2.02.0
Change in fecal boli incidents, locomotor task3.23.13.21.8-1.7
Time >=10cm from walls, locomotor time 10.30.30.40.6-0.6
Bouts of movement, locomotor time 10.00.00.0-0.20.2
Total resting periods, locomotor time 10.10.20.2-0.40.4
Rest time, locomotor task time 10.30.30.4-0.60.5
Distance moved, locomotor task time 11.31.41.61.3-1.1
Vertical activity count, locomotor time 10.80.80.80.9-0.8
Time >=10cm from walls, locomotor time 20.70.80.90.9-0.8
Bouts of movement, locomotor time 20.10.20.2-0.40.4
Total resting periods, locomotor time 20.20.20.2-0.40.4
Rest time, locomotor task time 21.11.21.31.1-1.1
Distance moved, locomotor task time 20.20.20.20.5-0.4
Vertical activity count, locomotor time 20.00.00.00.1-0.1
Weight adjusted by age1.21.31.31.2-1.2
Seeking ratio, delayed vs. immediate footshock0.30.30.3-0.60.6
Locomotion in novel chamber0.70.90.91.0-0.9
Locomotion in novel chamber post-restriction1.21.51.5-1.21.2
Progressive ratio0.00.00.0-0.10.1
Food seeking constrained by brief footshock1.01.31.3-1.11.1
Seeking ratio, punishment vs. effort0.00.00.00.1-0.1
Run reversals in cocaine runway, females0.40.40.50.5-0.7
Run reversals in cocaine runway, males0.60.60.6-0.80.7
Latency to leave start box in cocaine runway3.74.14.2-2.02.1
Latency to leave start box in cocaine runway, F5.25.75.9-2.32.4
Latency to leave start box in cocaine runway, M1.21.21.2-1.01.1
Cd content in liver0.60.70.70.8-0.8
Co content in liver0.00.00.0-0.20.2
Cu content in liver1.51.81.91.4-1.3
Fe content in liver1.01.21.31.1-1.1
K content in liver0.40.40.5-0.60.7
Mg content in liver0.30.30.40.6-0.6
Mn content in liver2.52.92.91.7-1.7
Na content in liver1.11.21.2-1.11.1
Rb content in liver0.00.00.0-0.00.0
Se content in liver0.40.50.5-0.70.7
Sr content in liver2.62.42.41.6-1.5
Zn content in liver0.00.10.1-0.20.2