# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | alternative polyA | ENSRNOT00000010338 | 0.0222 | 0.0181 | 9.5e-03 | 0.001 | 0.003 | 0.001 | 0.001 | 2.1e-01 | 1.2e-01 | 2.5e-01 | 2.5e-01 |
2 | Adipose | gene expression | ENSRNOG00000007822 | 0.0210 | 0.0170 | 8.8e-03 | 0.013 | 0.013 | 0.010 | 0.008 | 1.3e-02 | 1.1e-02 | 2.7e-02 | 3.8e-02 |
3 | BLA | gene expression | ENSRNOG00000007822 | 0.2467 | 0.1187 | 8.1e-10 | 0.151 | 0.161 | 0.153 | 0.059 | 1.9e-08 | 5.6e-09 | 1.5e-08 | 4.4e-04 |
4 | BLA | mRNA stability | ENSRNOG00000007822 | 0.3700 | 0.1500 | 6.7e-13 | 0.200 | 0.212 | 0.190 | 0.194 | 5.7e-11 | 1.4e-11 | 1.9e-10 | 1.2e-10 |
5 | Brain | alternative polyA | ENSRNOT00000095273 | 0.0770 | 0.0520 | 9.8e-06 | 0.056 | 0.053 | 0.054 | 0.053 | 6.6e-06 | 1.1e-05 | 9.2e-06 | 1.1e-05 |
6 | Brain | alternative polyA | ENSRNOT00000113899 | 0.0760 | 0.0510 | 1.1e-05 | 0.053 | 0.052 | 0.053 | 0.052 | 1.1e-05 | 1.2e-05 | 1.2e-05 | 1.3e-05 |
7 | Brain | alternative polyA | ENSRNOT00000010338 | 0.0650 | 0.0450 | 7.5e-05 | 0.044 | 0.043 | 0.041 | 0.040 | 5.6e-05 | 7.3e-05 | 1.1e-04 | 1.3e-04 |
8 | Brain | alternative polyA | ENSRNOT00000095273 | 0.0670 | 0.0460 | 5.6e-05 | 0.046 | 0.045 | 0.043 | 0.043 | 3.9e-05 | 4.9e-05 | 7.4e-05 | 7.3e-05 |
9 | Brain | gene expression | ENSRNOG00000007822 | 0.1500 | 0.0810 | 3.8e-12 | 0.097 | 0.141 | 0.134 | 0.134 | 2.5e-09 | 5.3e-13 | 1.9e-12 | 2.0e-12 |
10 | Brain | mRNA stability | ENSRNOG00000007822 | 0.3592 | 0.1716 | 1.9e-14 | 0.122 | 0.147 | 0.114 | 0.140 | 2.2e-11 | 1.5e-13 | 9.7e-11 | 6.0e-13 |
11 | IL | gene expression | ENSRNOG00000007822 | 0.2060 | 0.1310 | 2.0e-03 | 0.101 | 0.120 | 0.118 | 0.099 | 2.2e-03 | 8.4e-04 | 9.5e-04 | 2.3e-03 |
12 | LHb | gene expression | ENSRNOG00000007822 | 0.2488 | 0.1502 | 1.2e-03 | 0.064 | 0.088 | 0.063 | 0.075 | 1.3e-02 | 4.1e-03 | 1.3e-02 | 7.6e-03 |
13 | LHb | mRNA stability | ENSRNOG00000007822 | 0.1630 | 0.1100 | 5.4e-03 | 0.056 | 0.062 | 0.012 | 0.055 | 1.9e-02 | 1.4e-02 | 1.7e-01 | 2.0e-02 |
14 | Liver | gene expression | ENSRNOG00000007822 | 0.0500 | 0.0360 | 2.6e-05 | 0.040 | 0.045 | 0.020 | 0.038 | 2.8e-05 | 8.5e-06 | 2.4e-03 | 3.9e-05 |
15 | NAcc | gene expression | ENSRNOG00000007822 | 0.3200 | 0.1300 | 0.0e+00 | 0.255 | 0.277 | 0.294 | 0.270 | 4.8e-19 | 8.7e-21 | 3.8e-22 | 3.0e-20 |
16 | NAcc | mRNA stability | ENSRNOG00000007822 | 0.0937 | 0.0644 | 1.7e-05 | 0.055 | 0.064 | 0.051 | 0.056 | 5.7e-05 | 1.5e-05 | 1.2e-04 | 5.2e-05 |
17 | OFC | gene expression | ENSRNOG00000007822 | 0.1930 | 0.1249 | 2.7e-03 | 0.115 | 0.052 | 0.033 | 0.066 | 1.1e-03 | 2.2e-02 | 5.8e-02 | 1.1e-02 |
18 | OFC | mRNA stability | ENSRNOG00000007822 | 0.2416 | 0.1418 | 3.1e-04 | 0.134 | 0.145 | 0.118 | 0.109 | 4.5e-04 | 2.7e-04 | 1.0e-03 | 1.5e-03 |
19 | PL | gene expression | ENSRNOG00000007822 | 0.1640 | 0.0854 | 9.6e-11 | 0.131 | 0.153 | 0.151 | 0.152 | 3.8e-10 | 9.6e-12 | 1.5e-11 | 1.2e-11 |
20 | PL | mRNA stability | ENSRNOG00000007822 | 0.1530 | 0.0847 | 9.8e-10 | 0.120 | 0.130 | 0.122 | 0.125 | 2.1e-09 | 4.7e-10 | 1.5e-09 | 9.2e-10 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Saline control response | 6.4 | 8.6 | 10.5 | -2.4 | 2.7 | -2.6 | 3.2 | 3.2 | -3.2 | -3.2 | 3.2 | -3.0 | 2.8 | -2.8 | -3.0 | 2.9 | -2.3 | -2.6 | 3.2 | -2.2 | 3.0 | -3.2 | 3.2 |
Rest time, locomotor task time 1 | 6.0 | 6.6 | 9.4 | 0.7 | -3.1 | 3.0 | -2.7 | -2.4 | 2.4 | 2.6 | -2.6 | 3.0 | -1.4 | 3.1 | 3.0 | -1.6 | 3.0 | 3.1 | -2.3 | 3.0 | -1.8 | 2.8 | -2.3 |
Distance moved, locomotor task time 1 | 5.6 | 6.1 | 9.0 | -0.7 | 3.0 | -2.9 | 2.7 | 2.2 | -2.2 | -2.3 | 2.3 | -3.0 | 1.3 | -3.0 | -3.0 | 1.6 | -2.9 | -2.8 | 2.3 | -2.8 | 1.8 | -2.8 | 2.3 |
Extensor digitorum longus weight | 5.5 | 22.3 | 34.7 | 0.6 | -5.8 | 5.9 | -4.8 | -4.6 | 4.6 | 4.4 | -4.4 | 5.5 | -2.5 | 5.8 | 5.7 | -2.4 | 5.9 | 5.8 | -3.9 | 5.6 | -2.8 | 5.1 | -4.0 |
Condit. Reinf. active-inactive response ratio | 5.1 | 5.5 | 7.3 | -0.9 | 2.7 | -2.7 | 2.5 | 2.4 | -2.4 | -2.3 | 2.3 | -2.7 | 1.8 | -2.7 | -2.7 | 1.7 | -2.6 | -2.5 | 2.2 | -2.4 | 1.8 | -2.6 | 2.2 |
Condit. Reinf. active minus inactive responses | 4.8 | 5.4 | 6.6 | -1.3 | 2.5 | -2.5 | 2.5 | 2.4 | -2.4 | -2.6 | 2.6 | -2.5 | 1.8 | -2.5 | -2.5 | 1.9 | -2.3 | -2.2 | 2.3 | -2.2 | 2.0 | -2.5 | 2.3 |
Intermittent access intake escalation 2 | 4.3 | 4.2 | 6.0 | 0.8 | -2.4 | 2.3 | -2.3 | -2.0 | 2.0 | 1.7 | -1.7 | 2.5 | -1.3 | 2.4 | 2.4 | -1.5 | 2.3 | 2.2 | -2.0 | 2.2 | -1.7 | 2.3 | -2.0 |
Locomotor testing rearing | 4.1 | 6.4 | 8.0 | -1.4 | 2.6 | -2.6 | 2.8 | 2.6 | -2.6 | -2.8 | 2.8 | -2.8 | 1.9 | -2.7 | -2.7 | 2.1 | -2.5 | -2.5 | 2.5 | -2.4 | 2.2 | -2.8 | 2.5 |
Bone: trabecular tissue density | 3.8 | 5.3 | 7.4 | -1.8 | 2.1 | -2.1 | 2.4 | 2.5 | -2.5 | -2.7 | 2.7 | -2.3 | 2.6 | -2.2 | -2.3 | 2.3 | -1.9 | -2.0 | 2.4 | -1.6 | 2.4 | -2.4 | 2.5 |
Active lever presses in extinction session 6 | 3.7 | 3.5 | 5.2 | 0.4 | -2.2 | 2.3 | -1.9 | -1.9 | 1.9 | 2.2 | -2.2 | 2.1 | -1.2 | 2.2 | 2.2 | -1.1 | 2.2 | 1.7 | -1.6 | 2.0 | -1.2 | 2.0 | -1.6 |
Total sessions with >9 infusions | 3.3 | 3.6 | 5.0 | -1.6 | 1.6 | -1.6 | 2.1 | 2.2 | -2.2 | -2.2 | 2.2 | -1.9 | 1.6 | -1.7 | -1.8 | 1.9 | -1.4 | -1.8 | 2.1 | -1.5 | 2.0 | -2.0 | 2.1 |
Reaction time num false alarms | 3.2 | 4.4 | 5.7 | 1.8 | -1.9 | 1.8 | -2.4 | -2.2 | 2.2 | 2.3 | -2.3 | 2.2 | -2.0 | 2.0 | 2.1 | -2.2 | 1.5 | 1.8 | -2.4 | 1.6 | -2.3 | 2.3 | -2.4 |
Context. condit. distance diff. score | 3.2 | 3.9 | 5.4 | 0.6 | -2.3 | 2.3 | -2.0 | -1.9 | 1.9 | 2.0 | -2.0 | 2.3 | -1.4 | 2.3 | 2.3 | -1.3 | 2.3 | 2.3 | -1.8 | 2.1 | -1.4 | 2.2 | -1.8 |
Cd content in liver | 3.2 | 3.6 | 4.9 | 1.4 | -1.8 | 1.8 | -2.0 | -2.1 | 2.1 | 2.2 | -2.2 | 1.9 | -2.0 | 1.9 | 1.9 | -1.8 | 1.6 | 1.7 | -2.0 | 1.5 | -1.8 | 2.0 | -2.0 |
Incentive salience index mean | 3.1 | 3.7 | 5.1 | -0.6 | 2.2 | -2.3 | 2.1 | 1.9 | -1.9 | -2.1 | 2.1 | -2.2 | 1.1 | -2.2 | -2.2 | 1.2 | -2.2 | -2.1 | 1.7 | -2.1 | 1.4 | -2.1 | 1.7 |
Latency to leave start box in cocaine runway | 2.9 | 3.1 | 4.8 | -0.3 | 2.2 | -2.2 | 1.7 | 1.6 | -1.6 | -2.0 | 2.0 | -2.0 | 1.2 | -2.1 | -2.1 | 1.0 | -2.2 | -1.9 | 1.4 | -1.9 | 1.1 | -1.9 | 1.5 |
Breakpoint value in progressive ratio session | 2.8 | 3.1 | 4.9 | 0.3 | -2.2 | 2.2 | -1.8 | -1.7 | 1.7 | 1.8 | -1.8 | 2.1 | -1.0 | 2.2 | 2.1 | -0.9 | 2.2 | 2.1 | -1.5 | 1.9 | -1.1 | 1.9 | -1.5 |
Vertical activity count, locomotor time 1 | 2.8 | 3.0 | 4.0 | -0.9 | 1.9 | -1.8 | 1.9 | 1.5 | -1.5 | -1.6 | 1.6 | -2.0 | 1.3 | -1.9 | -2.0 | 1.5 | -1.7 | -1.9 | 1.8 | -1.8 | 1.5 | -2.0 | 1.8 |
Social response proportion | 2.6 | 2.9 | 4.3 | -0.7 | 1.9 | -1.9 | 1.7 | 1.5 | -1.5 | -1.6 | 1.6 | -1.9 | 1.6 | -1.9 | -2.0 | 1.3 | -1.9 | -2.1 | 1.6 | -1.8 | 1.4 | -1.9 | 1.6 |
Cocaine response after cond. not corrected | 2.6 | 2.9 | 7.3 | 1.1 | 2.4 | -2.5 | 1.4 | 1.0 | -1.0 | -1.0 | 1.0 | -2.0 | -0.2 | -2.3 | -2.1 | -0.2 | -2.7 | -2.6 | 0.7 | -2.6 | 0.1 | -1.6 | 0.7 |
Locomotion distance, session 8 | 2.6 | 3.9 | 5.3 | 1.7 | -1.8 | 1.7 | -2.2 | -2.1 | 2.1 | 2.3 | -2.3 | 2.0 | -2.1 | 1.8 | 1.9 | -2.1 | 1.5 | 1.6 | -2.2 | 1.3 | -2.1 | 2.2 | -2.2 |
Time >=10cm from walls, locomotor time 1 | 2.6 | 2.6 | 5.1 | -0.0 | 2.1 | -2.1 | 1.5 | 1.1 | -1.1 | -1.7 | 1.7 | -1.8 | 0.9 | -2.0 | -1.9 | 0.7 | -2.1 | -2.3 | 1.1 | -2.1 | 0.9 | -1.8 | 1.2 |
Latency to leave start box in cocaine runway, M | 2.6 | 2.5 | 3.8 | -1.0 | 1.6 | -1.6 | 1.7 | 1.5 | -1.5 | -2.0 | 2.0 | -1.6 | 1.4 | -1.6 | -1.7 | 1.4 | -1.4 | -1.5 | 1.6 | -1.2 | 1.5 | -1.8 | 1.6 |
Reaction time num false alarms AUC | 2.5 | 3.5 | 5.0 | 1.9 | -1.5 | 1.5 | -2.1 | -1.9 | 1.9 | 2.0 | -2.0 | 1.8 | -2.1 | 1.6 | 1.7 | -2.2 | 1.1 | 1.5 | -2.2 | 1.2 | -2.2 | 2.1 | -2.2 |
Intermittent access intake day 1-15 change | 2.5 | 2.4 | 4.6 | 0.1 | -2.0 | 2.0 | -1.6 | -1.5 | 1.5 | 1.1 | -1.1 | 1.9 | -0.7 | 2.0 | 1.9 | -0.7 | 2.0 | 2.1 | -1.3 | 1.9 | -0.9 | 1.7 | -1.3 |
Median of all reaction times | 2.3 | 3.2 | 4.4 | -1.7 | 1.5 | -1.5 | 2.0 | 2.0 | -2.0 | -1.7 | 1.7 | -1.8 | 1.9 | -1.6 | -1.7 | 2.0 | -1.2 | -1.5 | 2.1 | -1.0 | 2.0 | -2.0 | 2.1 |
Condit. Reinf. active responses | 2.3 | 2.8 | 4.3 | -1.5 | 1.4 | -1.4 | 1.8 | 1.9 | -1.9 | -2.1 | 2.1 | -1.6 | 1.7 | -1.5 | -1.6 | 1.7 | -1.2 | -1.2 | 1.9 | -1.1 | 1.8 | -1.7 | 1.9 |
Time to tail flick, vehicle, before self-admin | 2.3 | 2.3 | 3.9 | -0.2 | 1.9 | -2.0 | 1.6 | 1.6 | -1.6 | -1.1 | 1.1 | -1.8 | 0.7 | -1.9 | -1.8 | 0.8 | -1.9 | -1.9 | 1.3 | -1.8 | 1.0 | -1.7 | 1.3 |
Reaction time mean | 2.2 | 3.1 | 4.2 | -1.6 | 1.6 | -1.6 | 2.0 | 1.9 | -1.9 | -1.6 | 1.6 | -1.8 | 1.8 | -1.7 | -1.8 | 1.9 | -1.3 | -1.6 | 2.0 | -1.1 | 2.0 | -2.0 | 2.0 |
Condit. Reinf. inactive responses | 2.1 | 2.6 | 4.6 | -1.5 | 1.3 | -1.3 | 1.7 | 1.7 | -1.7 | -2.1 | 2.1 | -1.5 | 1.8 | -1.4 | -1.5 | 1.8 | -1.0 | -1.2 | 1.8 | -1.0 | 1.8 | -1.7 | 1.8 |
Intermittent access terminal intake (last 3 days) | 2.1 | 2.3 | 6.2 | -1.1 | -2.2 | 2.3 | -1.2 | -1.3 | 1.3 | 0.7 | -0.7 | 1.8 | 0.1 | 2.1 | 2.0 | 0.2 | 2.5 | 2.0 | -0.6 | 2.1 | -0.0 | 1.4 | -0.7 |
Indifference point function ln k | 2.0 | 2.8 | 4.1 | 0.9 | -1.8 | 1.8 | -1.8 | -1.5 | 1.5 | 2.0 | -2.0 | 1.8 | -1.4 | 1.8 | 1.8 | -1.4 | 1.7 | 1.7 | -1.6 | 1.6 | -1.5 | 1.9 | -1.6 |
Indifference point function log k | 2.0 | 2.8 | 4.1 | 0.9 | -1.8 | 1.8 | -1.8 | -1.5 | 1.5 | 2.0 | -2.0 | 1.8 | -1.4 | 1.8 | 1.8 | -1.4 | 1.7 | 1.7 | -1.6 | 1.6 | -1.5 | 1.9 | -1.6 |
Reaction time mean AUC | 2.0 | 2.7 | 3.7 | -1.5 | 1.5 | -1.5 | 1.9 | 1.8 | -1.8 | -1.4 | 1.4 | -1.7 | 1.5 | -1.6 | -1.7 | 1.8 | -1.2 | -1.5 | 1.9 | -1.1 | 1.8 | -1.9 | 1.9 |
Number of responses in last shaping day | 2.0 | 2.1 | 4.6 | -0.5 | -2.0 | 2.1 | -1.2 | -1.2 | 1.2 | 1.7 | -1.7 | 1.6 | -0.7 | 1.9 | 1.8 | -0.2 | 2.1 | 1.4 | -0.7 | 1.6 | -0.4 | 1.4 | -0.9 |
Intermittent access day 15 total locomotion | 1.9 | 2.0 | 5.6 | -0.6 | -1.9 | 2.0 | -1.2 | -1.5 | 1.5 | 0.5 | -0.5 | 1.6 | -0.0 | 1.9 | 1.7 | -0.1 | 2.1 | 2.4 | -0.8 | 1.8 | -0.3 | 1.3 | -0.8 |
Co content in liver | 1.9 | 2.2 | 4.0 | 0.1 | -1.9 | 1.9 | -1.5 | -1.2 | 1.2 | 1.3 | -1.3 | 1.8 | -0.7 | 1.9 | 1.8 | -0.7 | 1.9 | 2.0 | -1.2 | 1.9 | -0.9 | 1.7 | -1.2 |
Time to tail flick, vehicle, after self-admin | 1.8 | 2.0 | 3.6 | 1.8 | -0.8 | 0.8 | -1.5 | -1.9 | 1.9 | 1.3 | -1.3 | 1.1 | -1.9 | 1.0 | 1.1 | -1.8 | 0.6 | 0.7 | -1.7 | 0.5 | -1.8 | 1.4 | -1.7 |
Baseline Anxiety | 1.7 | 1.8 | 6.8 | 0.9 | 1.8 | -1.8 | 1.0 | 0.6 | -0.6 | -0.7 | 0.7 | -1.6 | -0.5 | -1.8 | -1.6 | -0.2 | -2.0 | -2.6 | 0.5 | -2.1 | -0.1 | -1.2 | 0.5 |
Intermittent access intake escalation | 1.6 | 1.6 | 3.3 | -0.3 | -1.7 | 1.8 | -1.2 | -1.0 | 1.0 | 0.6 | -0.6 | 1.6 | -0.2 | 1.7 | 1.6 | -0.3 | 1.8 | 1.8 | -0.9 | 1.7 | -0.5 | 1.4 | -0.9 |
Na content in liver | 1.6 | 1.7 | 2.8 | -0.2 | 1.6 | -1.6 | 1.3 | 1.4 | -1.4 | -1.0 | 1.0 | -1.5 | 0.8 | -1.6 | -1.6 | 0.7 | -1.7 | -1.6 | 1.1 | -1.6 | 0.8 | -1.4 | 1.1 |
Condit. Reinf. lever reinforcers received | 1.5 | 2.2 | 3.4 | -0.3 | 1.8 | -1.8 | 1.6 | 1.4 | -1.4 | -1.2 | 1.2 | -1.8 | 0.6 | -1.8 | -1.8 | 0.9 | -1.8 | -1.8 | 1.3 | -1.8 | 1.0 | -1.7 | 1.3 |
Locomotion velocity, session 3 | 1.5 | 1.7 | 3.4 | -1.1 | 1.1 | -1.1 | 1.5 | 1.8 | -1.8 | -1.2 | 1.2 | -1.3 | 1.1 | -1.2 | -1.3 | 1.3 | -1.0 | -0.8 | 1.5 | -1.0 | 1.4 | -1.3 | 1.5 |
Delay discounting total patch changes 18 sec | 1.4 | 1.8 | 3.7 | -0.9 | 1.3 | -1.2 | 1.4 | 1.1 | -1.1 | -1.9 | 1.9 | -1.3 | 1.4 | -1.3 | -1.3 | 1.3 | -1.1 | -1.4 | 1.3 | -1.2 | 1.3 | -1.5 | 1.3 |
Cocaine response before conditioning | 1.4 | 1.7 | 2.6 | -1.2 | 1.1 | -1.1 | 1.4 | 1.6 | -1.6 | -1.5 | 1.5 | -1.3 | 1.6 | -1.2 | -1.3 | 1.4 | -1.0 | -0.8 | 1.5 | -0.8 | 1.4 | -1.4 | 1.5 |
Distance traveled before self-admin | 1.4 | 1.5 | 4.0 | 0.5 | 1.6 | -1.6 | 0.9 | 1.0 | -1.0 | -0.9 | 0.9 | -1.5 | 0.1 | -1.6 | -1.5 | 0.1 | -1.8 | -2.0 | 0.7 | -1.6 | 0.2 | -1.1 | 0.7 |
Distance moved, locomotor task time 2 | 1.4 | 1.7 | 2.5 | -0.4 | 1.5 | -1.5 | 1.5 | 1.0 | -1.0 | -1.4 | 1.4 | -1.6 | 0.6 | -1.5 | -1.5 | 0.9 | -1.4 | -1.4 | 1.3 | -1.4 | 1.0 | -1.5 | 1.3 |
BMI without tail | 1.3 | 2.8 | 4.0 | 1.8 | -1.3 | 1.2 | -1.8 | -1.9 | 1.9 | 1.7 | -1.7 | 1.6 | -1.9 | 1.4 | 1.5 | -2.0 | 1.0 | 1.3 | -2.0 | 1.1 | -2.0 | 1.8 | -2.0 |
Reaction time false alarm rate | 1.3 | 1.9 | 3.8 | 2.0 | -0.7 | 0.7 | -1.5 | -1.3 | 1.3 | 1.7 | -1.7 | 1.1 | -1.8 | 0.8 | 1.0 | -2.0 | 0.3 | 0.8 | -1.7 | 0.5 | -1.9 | 1.4 | -1.7 |
Short access day 1 total inactive lever presses | 1.3 | 1.5 | 2.2 | -0.5 | 1.4 | -1.5 | 1.5 | 1.2 | -1.2 | -0.9 | 0.9 | -1.5 | 0.6 | -1.4 | -1.4 | 0.9 | -1.3 | -1.2 | 1.2 | -1.3 | 1.0 | -1.4 | 1.2 |
Locomotion distance, session 3 | 1.3 | 1.4 | 2.3 | -0.6 | 1.2 | -1.2 | 1.3 | 1.5 | -1.5 | -1.2 | 1.2 | -1.3 | 0.8 | -1.2 | -1.3 | 0.9 | -1.1 | -0.9 | 1.2 | -1.1 | 1.0 | -1.2 | 1.2 |
Bone: elastic displacement | 1.3 | 1.4 | 3.2 | -1.8 | 0.5 | -0.5 | 1.2 | 1.2 | -1.2 | -1.4 | 1.4 | -0.8 | 1.7 | -0.6 | -0.8 | 1.7 | -0.2 | -0.4 | 1.5 | -0.1 | 1.7 | -1.2 | 1.5 |
Delta distance traveled before/after self-admin | 1.3 | 1.4 | 5.6 | -2.4 | -0.5 | 0.6 | 0.7 | 0.7 | -0.7 | -1.2 | 1.2 | 0.0 | 2.1 | 0.4 | 0.1 | 1.9 | 1.0 | 0.6 | 1.2 | 1.0 | 1.8 | -0.6 | 1.2 |
Latency to leave start box in cocaine runway, F | 1.3 | 1.4 | 2.2 | -0.2 | 1.4 | -1.4 | 1.1 | 1.1 | -1.1 | -1.4 | 1.4 | -1.4 | 0.9 | -1.5 | -1.4 | 0.6 | -1.5 | -1.2 | 0.9 | -1.3 | 0.7 | -1.3 | 1.0 |
Cocaine response after cond. corrected | 1.2 | 1.4 | 3.7 | 1.8 | 1.5 | -1.6 | 0.4 | -0.0 | 0.0 | 0.0 | -0.0 | -1.0 | -1.1 | -1.4 | -1.2 | -1.1 | -1.9 | -1.8 | -0.3 | -1.9 | -0.9 | -0.6 | -0.3 |
Intermittent access day 15 total infusions | 1.2 | 1.3 | 4.0 | -1.6 | -1.7 | 1.8 | -0.5 | -0.6 | 0.6 | -0.1 | 0.1 | 1.2 | 0.8 | 1.5 | 1.3 | 0.8 | 2.0 | 1.6 | 0.1 | 1.6 | 0.6 | 0.7 | 0.0 |
Post-drug Anxiety | 1.2 | 1.3 | 3.4 | 0.7 | 1.7 | -1.7 | 1.0 | 1.0 | -1.0 | -0.5 | 0.5 | -1.4 | -0.3 | -1.6 | -1.5 | -0.1 | -1.8 | -1.1 | 0.6 | -1.7 | 0.1 | -1.1 | 0.6 |
One hour access (0.3 mA shock) | 1.2 | 1.4 | 6.1 | -2.5 | -1.3 | 1.5 | 0.2 | 0.0 | -0.0 | -0.7 | 0.7 | 0.7 | 1.5 | 1.1 | 0.9 | 1.7 | 1.8 | 1.1 | 0.9 | 1.3 | 1.5 | 0.1 | 0.8 |
Bone: trabecular number | 1.2 | 1.9 | 3.5 | -1.1 | 1.3 | -1.3 | 1.7 | 1.9 | -1.9 | -1.3 | 1.3 | -1.5 | 0.7 | -1.4 | -1.4 | 1.3 | -1.1 | -0.9 | 1.6 | -1.2 | 1.4 | -1.5 | 1.5 |
Distance traveled after self-admin | 1.2 | 1.3 | 2.1 | -0.9 | 1.0 | -1.0 | 1.2 | 1.2 | -1.2 | -1.4 | 1.4 | -1.1 | 1.2 | -1.0 | -1.1 | 1.1 | -0.9 | -1.4 | 1.2 | -0.7 | 1.2 | -1.2 | 1.2 |
Condit. Reinf. active responses | 1.1 | 1.5 | 2.2 | -0.5 | 1.5 | -1.4 | 1.4 | 1.1 | -1.1 | -1.1 | 1.1 | -1.5 | 0.6 | -1.4 | -1.4 | 0.9 | -1.4 | -1.4 | 1.2 | -1.4 | 1.0 | -1.4 | 1.2 |
Short access day 10 total inactive lever presses | 1.1 | 1.2 | 5.1 | 2.2 | 1.0 | -1.1 | -0.2 | -0.1 | 0.1 | 0.4 | -0.4 | -0.5 | -1.8 | -0.9 | -0.6 | -1.6 | -1.5 | -1.1 | -0.9 | -1.1 | -1.5 | 0.1 | -0.8 |
One hour access (shock baseline) | 1.1 | 1.2 | 4.0 | -1.4 | -1.7 | 1.8 | -0.6 | -0.8 | 0.8 | 0.4 | -0.4 | 1.2 | 0.4 | 1.5 | 1.4 | 0.7 | 2.0 | 1.3 | 0.0 | 1.4 | 0.5 | 0.8 | -0.1 |
Time >=10cm from walls, locomotor time 2 | 1.1 | 1.1 | 2.1 | 0.1 | 1.4 | -1.4 | 1.0 | 0.8 | -0.8 | -1.2 | 1.2 | -1.2 | 0.7 | -1.3 | -1.3 | 0.4 | -1.5 | -1.4 | 0.7 | -1.3 | 0.5 | -1.1 | 0.7 |
Seeking ratio, delayed vs. immediate footshock | 1.1 | 1.3 | 3.2 | -0.1 | -1.4 | 1.4 | -1.1 | -0.9 | 0.9 | 0.9 | -0.9 | 1.4 | -0.1 | 1.4 | 1.4 | -0.3 | 1.5 | 1.8 | -0.8 | 1.7 | -0.5 | 1.2 | -0.8 |
Indifference point AUC | 1.0 | 1.2 | 2.8 | -0.2 | 1.3 | -1.3 | 1.0 | 0.7 | -0.7 | -1.7 | 1.7 | -1.1 | 0.8 | -1.2 | -1.2 | 0.6 | -1.2 | -1.2 | 0.7 | -1.1 | 0.7 | -1.2 | 0.8 |
Condit. Reinf. active minus inactive responses | 1.0 | 1.3 | 2.7 | 0.1 | 1.5 | -1.5 | 1.3 | 0.8 | -0.8 | -0.6 | 0.6 | -1.5 | 0.0 | -1.5 | -1.4 | 0.4 | -1.5 | -1.5 | 0.9 | -1.7 | 0.6 | -1.3 | 0.9 |
Compulsive drug intake | 1.0 | 1.0 | 2.3 | -1.3 | 0.5 | -0.4 | 0.9 | 1.2 | -1.2 | -1.4 | 1.4 | -0.6 | 1.5 | -0.5 | -0.6 | 1.3 | -0.3 | -0.5 | 1.1 | -0.1 | 1.2 | -0.9 | 1.1 |
Locomotion velocity, session 7 | 1.0 | 1.1 | 1.7 | -0.7 | 1.1 | -1.1 | 1.3 | 1.3 | -1.3 | -0.7 | 0.7 | -1.2 | 0.6 | -1.1 | -1.2 | 1.0 | -1.0 | -0.9 | 1.2 | -1.1 | 1.0 | -1.2 | 1.2 |
Locomotion velocity, session 8 | 1.0 | 1.2 | 2.6 | 1.5 | -0.6 | 0.5 | -1.1 | -1.3 | 1.3 | 1.2 | -1.2 | 0.8 | -1.6 | 0.7 | 0.8 | -1.5 | 0.3 | 0.4 | -1.4 | 0.2 | -1.5 | 1.1 | -1.4 |
Delta time to tail flick, test, before/after SA | 1.0 | 0.9 | 1.6 | -0.0 | 1.2 | -1.3 | 1.0 | 0.4 | -0.4 | -1.0 | 1.0 | -1.1 | 0.4 | -1.2 | -1.1 | 0.5 | -1.2 | -1.3 | 0.7 | -1.2 | 0.6 | -1.1 | 0.7 |
Progressive ratio | 1.0 | 1.1 | 2.4 | 0.6 | -1.1 | 1.1 | -1.2 | -1.1 | 1.1 | 0.8 | -0.8 | 1.2 | -0.5 | 1.2 | 1.2 | -0.8 | 1.0 | 1.5 | -1.1 | 1.2 | -0.9 | 1.2 | -1.1 |
BMI with tail | 0.9 | 2.8 | 4.8 | 0.1 | -2.1 | 2.2 | -1.7 | -1.6 | 1.6 | 1.3 | -1.3 | 2.0 | -0.8 | 2.1 | 2.1 | -0.8 | 2.2 | 2.1 | -1.3 | 2.2 | -0.9 | 1.8 | -1.4 |
Right kidney weight | 0.9 | 2.6 | 7.0 | 1.5 | 2.4 | -2.5 | 1.2 | 0.4 | -0.4 | -1.3 | 1.3 | -1.8 | -0.7 | -2.1 | -1.9 | -0.5 | -2.6 | -2.3 | 0.3 | -2.6 | -0.2 | -1.4 | 0.3 |
Std. dev. time between licks in bursts | 0.9 | 1.1 | 2.7 | 1.6 | -0.4 | 0.3 | -1.0 | -1.2 | 1.2 | 1.2 | -1.2 | 0.6 | -1.6 | 0.4 | 0.6 | -1.5 | 0.0 | 0.1 | -1.3 | -0.1 | -1.5 | 0.9 | -1.3 |
Delay discounting total patch changes 24 sec | 0.9 | 1.1 | 2.7 | -1.6 | 0.4 | -0.3 | 1.1 | 0.8 | -0.8 | -1.6 | 1.6 | -0.6 | 1.6 | -0.4 | -0.6 | 1.6 | -0.0 | -0.4 | 1.2 | -0.1 | 1.5 | -1.0 | 1.2 |
Locomotor testing distance | 0.9 | 1.5 | 3.3 | 0.5 | 1.7 | -1.7 | 1.2 | 1.2 | -1.2 | -0.9 | 0.9 | -1.5 | -0.1 | -1.6 | -1.5 | 0.1 | -1.8 | -1.6 | 0.7 | -1.8 | 0.3 | -1.2 | 0.7 |
Conditioned reinforcement - actives | 0.9 | 0.9 | 3.0 | -1.7 | -1.2 | 1.3 | -0.0 | -0.3 | 0.3 | -0.5 | 0.5 | 0.7 | 0.9 | 1.1 | 0.9 | 1.1 | 1.5 | 1.4 | 0.5 | 1.1 | 1.0 | 0.2 | 0.4 |
Intermittent access total locomotion | 0.9 | 1.0 | 3.1 | -1.0 | -1.4 | 1.5 | -0.6 | -0.8 | 0.8 | 0.1 | -0.1 | 1.1 | 0.4 | 1.4 | 1.2 | 0.4 | 1.7 | 1.7 | -0.2 | 1.4 | 0.3 | 0.7 | -0.2 |
Incentive Sensitization - Breakpoint | 0.9 | 0.9 | 2.5 | -0.9 | -1.4 | 1.4 | -0.7 | -0.7 | 0.7 | 0.0 | -0.0 | 1.1 | 0.5 | 1.3 | 1.2 | 0.4 | 1.6 | 1.2 | -0.3 | 1.4 | 0.2 | 0.7 | -0.3 |
Time in closed arm after self-admin | 0.9 | 1.0 | 1.4 | 0.8 | -1.0 | 1.0 | -1.1 | -1.1 | 1.1 | 0.6 | -0.6 | 1.0 | -1.2 | 1.0 | 1.0 | -1.0 | 0.8 | 1.0 | -1.1 | 0.8 | -1.1 | 1.1 | -1.1 |
Food seeking constrained by brief footshock | 0.9 | 1.1 | 3.4 | -1.3 | -1.6 | 1.6 | -0.5 | -0.3 | 0.3 | 0.6 | -0.6 | 1.1 | 0.3 | 1.5 | 1.3 | 0.6 | 1.8 | 1.6 | -0.0 | 1.6 | 0.4 | 0.8 | -0.1 |
Rb content in liver | 0.9 | 1.2 | 1.6 | -0.3 | 1.2 | -1.2 | 1.2 | 1.1 | -1.1 | -1.1 | 1.1 | -1.3 | 0.4 | -1.3 | -1.2 | 0.7 | -1.2 | -1.2 | 1.0 | -1.2 | 0.8 | -1.2 | 1.0 |
Heart weight | 0.8 | 1.1 | 2.7 | -0.5 | -1.5 | 1.5 | -1.1 | -0.8 | 0.8 | 0.7 | -0.7 | 1.3 | 0.4 | 1.4 | 1.3 | -0.1 | 1.5 | 1.5 | -0.6 | 1.6 | -0.2 | 1.0 | -0.6 |
Soleus weight | 0.8 | 2.3 | 5.1 | -0.3 | -2.0 | 2.0 | -1.4 | -1.3 | 1.3 | 1.1 | -1.1 | 1.8 | -0.4 | 2.0 | 1.9 | -0.4 | 2.1 | 2.3 | -1.0 | 2.0 | -0.5 | 1.5 | -1.0 |
Pavlov. Cond. intertrial magazine entries | 0.8 | 1.0 | 2.0 | -1.2 | 0.7 | -0.7 | 1.0 | 1.1 | -1.1 | -1.0 | 1.0 | -0.9 | 1.4 | -0.8 | -0.9 | 1.3 | -0.5 | -0.5 | 1.2 | -0.4 | 1.2 | -1.0 | 1.2 |
Progressive ratio test 2 active lever presses | 0.8 | 0.8 | 2.6 | -1.6 | -1.2 | 1.3 | -0.1 | -0.3 | 0.3 | -0.5 | 0.5 | 0.7 | 1.0 | 1.1 | 0.9 | 1.0 | 1.5 | 1.0 | 0.4 | 1.1 | 0.9 | 0.3 | 0.3 |
Short access total infusions | 0.8 | 0.9 | 2.5 | -1.6 | 0.3 | -0.2 | 1.0 | 1.0 | -1.0 | -1.1 | 1.1 | -0.6 | 1.3 | -0.4 | -0.5 | 1.5 | 0.0 | -0.4 | 1.3 | -0.2 | 1.4 | -0.9 | 1.2 |
Stereotopy head waving bouts, day 7 | 0.8 | 0.9 | 1.8 | 0.2 | 1.3 | -1.3 | 0.8 | 0.9 | -0.9 | -0.7 | 0.7 | -1.1 | 0.3 | -1.2 | -1.2 | 0.2 | -1.3 | -1.2 | 0.6 | -1.2 | 0.3 | -0.9 | 0.6 |
Bone: stiffness | 0.8 | 1.2 | 1.7 | 0.5 | -1.2 | 1.2 | -1.2 | -0.9 | 0.9 | 1.2 | -1.2 | 1.2 | -0.9 | 1.2 | 1.2 | -0.9 | 1.1 | 1.3 | -1.0 | 1.1 | -0.9 | 1.3 | -1.0 |
Delta time to tail flick, vehicle, before/after SA | 0.8 | 0.8 | 1.4 | 1.1 | -0.6 | 0.6 | -1.0 | -1.2 | 1.2 | 0.7 | -0.7 | 0.8 | -1.2 | 0.7 | 0.7 | -1.1 | 0.4 | 0.5 | -1.1 | 0.4 | -1.1 | 0.9 | -1.1 |
Delay disc. indifference point, 0s delay | 0.8 | 0.8 | 2.7 | -1.6 | -0.1 | 0.1 | 0.7 | 1.0 | -1.0 | -1.0 | 1.0 | -0.3 | 1.5 | -0.1 | -0.2 | 1.4 | 0.4 | 0.3 | 1.1 | 0.5 | 1.3 | -0.6 | 1.1 |
Change in fecal boli incidents, locomotor task | 0.8 | 0.8 | 2.1 | -1.4 | 0.3 | -0.3 | 0.9 | 1.0 | -1.0 | -0.7 | 0.7 | -0.5 | 1.4 | -0.3 | -0.5 | 1.3 | -0.0 | 0.1 | 1.1 | 0.2 | 1.3 | -0.8 | 1.1 |
Rest time, locomotor task time 2 | 0.8 | 0.9 | 1.8 | 0.2 | -1.2 | 1.1 | -1.0 | -0.6 | 0.6 | 1.2 | -1.2 | 1.1 | -0.5 | 1.2 | 1.1 | -0.5 | 1.1 | 1.4 | -0.8 | 1.1 | -0.6 | 1.1 | -0.8 |
K content in liver | 0.8 | 0.8 | 2.3 | 1.3 | 1.2 | -1.2 | 0.3 | 0.2 | -0.2 | 0.0 | -0.0 | -0.8 | -0.8 | -1.1 | -0.9 | -0.8 | -1.5 | -1.3 | -0.2 | -1.5 | -0.6 | -0.5 | -0.1 |
Se content in liver | 0.8 | 0.9 | 1.3 | 0.4 | -1.1 | 1.1 | -1.0 | -0.9 | 0.9 | 1.1 | -1.1 | 1.1 | -0.8 | 1.1 | 1.1 | -0.7 | 1.1 | 1.1 | -0.9 | 0.9 | -0.7 | 1.0 | -0.9 |
Zn content in liver | 0.8 | 0.9 | 2.9 | 1.7 | -0.1 | 0.1 | -0.9 | -1.1 | 1.1 | 1.0 | -1.0 | 0.4 | -1.5 | 0.2 | 0.3 | -1.5 | -0.2 | -0.1 | -1.2 | -0.3 | -1.4 | 0.7 | -1.2 |
Locomotor activity | 0.7 | 1.1 | 2.5 | 0.5 | 1.4 | -1.5 | 0.9 | 1.1 | -1.1 | -0.5 | 0.5 | -1.2 | 0.0 | -1.4 | -1.3 | 0.0 | -1.6 | -1.3 | 0.6 | -1.4 | 0.2 | -0.9 | 0.6 |
Incentive Sensitization - Responses | 0.7 | 0.7 | 2.0 | -1.0 | -1.2 | 1.3 | -0.5 | -0.5 | 0.5 | -0.1 | 0.1 | 0.9 | 0.6 | 1.1 | 1.0 | 0.5 | 1.4 | 1.0 | -0.1 | 1.2 | 0.4 | 0.6 | -0.1 |
Progressive ratio test 2 breakpoint | 0.7 | 0.8 | 2.3 | -1.5 | -1.1 | 1.2 | -0.1 | -0.4 | 0.4 | -0.5 | 0.5 | 0.7 | 0.9 | 1.0 | 0.8 | 1.0 | 1.4 | 1.1 | 0.3 | 1.1 | 0.8 | 0.3 | 0.3 |
Short access day 1 locomotion | 0.7 | 0.8 | 1.9 | -0.4 | -1.2 | 1.3 | -0.6 | -0.9 | 0.9 | 0.6 | -0.6 | 1.0 | -0.5 | 1.2 | 1.1 | -0.0 | 1.4 | 1.1 | -0.4 | 1.1 | -0.1 | 0.8 | -0.5 |
Short access total locomotion | 0.7 | 0.8 | 1.9 | -1.4 | 0.3 | -0.2 | 0.9 | 0.7 | -0.7 | -1.3 | 1.3 | -0.6 | 1.2 | -0.3 | -0.5 | 1.3 | 0.0 | -0.2 | 1.1 | -0.1 | 1.3 | -0.8 | 1.1 |
Total locomotion distance, hab. session 2 | 0.7 | 0.9 | 2.5 | 0.7 | 1.4 | -1.4 | 0.8 | 0.4 | -0.4 | -0.4 | 0.4 | -1.2 | -0.4 | -1.3 | -1.2 | -0.2 | -1.5 | -1.5 | 0.4 | -1.6 | -0.0 | -0.9 | 0.4 |
Locomotion velocity, hab. session 2 | 0.7 | 0.9 | 2.3 | 0.6 | 1.3 | -1.4 | 0.8 | 0.5 | -0.5 | -0.5 | 0.5 | -1.2 | -0.3 | -1.3 | -1.2 | -0.1 | -1.5 | -1.5 | 0.4 | -1.5 | 0.1 | -0.9 | 0.4 |
Bone: maximum force | 0.7 | 1.2 | 2.9 | -0.1 | -1.5 | 1.5 | -1.1 | -0.5 | 0.5 | 0.9 | -0.9 | 1.3 | -0.4 | 1.4 | 1.3 | -0.4 | 1.5 | 1.7 | -0.7 | 1.5 | -0.5 | 1.3 | -0.7 |
Bone: minimum diameter | 0.7 | 1.3 | 2.6 | -0.2 | -1.5 | 1.6 | -1.2 | -1.0 | 1.0 | 0.7 | -0.7 | 1.4 | -0.1 | 1.5 | 1.4 | -0.3 | 1.5 | 1.6 | -0.8 | 1.6 | -0.5 | 1.2 | -0.8 |
Bone: tissue strength | 0.7 | 0.7 | 1.0 | -0.2 | 1.0 | -1.0 | 0.9 | 1.0 | -1.0 | -0.6 | 0.6 | -1.0 | 0.3 | -1.0 | -1.0 | 0.5 | -0.9 | -0.8 | 0.8 | -0.9 | 0.6 | -0.9 | 0.8 |
Delta ambulatory time before/after self-admin | 0.7 | 0.8 | 3.5 | -1.9 | -0.5 | 0.6 | 0.5 | 0.4 | -0.4 | -0.6 | 0.6 | 0.1 | 1.5 | 0.4 | 0.2 | 1.5 | 0.9 | 0.6 | 0.9 | 0.9 | 1.4 | -0.3 | 0.9 |
Ambulatory time before self-admin | 0.7 | 0.7 | 2.2 | 0.8 | 1.1 | -1.1 | 0.5 | 0.5 | -0.5 | -0.6 | 0.6 | -0.9 | -0.3 | -1.1 | -1.0 | -0.3 | -1.3 | -1.5 | 0.2 | -1.2 | -0.2 | -0.6 | 0.2 |
Locomotion in novel chamber post-restriction | 0.7 | 0.8 | 2.7 | 1.7 | 0.2 | -0.3 | -0.6 | -0.8 | 0.8 | 1.2 | -1.2 | 0.2 | -1.5 | -0.1 | 0.1 | -1.4 | -0.5 | -0.8 | -1.0 | -0.6 | -1.3 | 0.5 | -1.0 |
Glucose | 0.6 | 0.9 | 2.3 | -0.7 | -1.3 | 1.4 | -0.7 | -0.4 | 0.4 | 0.6 | -0.6 | 1.1 | 0.2 | 1.3 | 1.2 | 0.2 | 1.5 | 1.4 | -0.3 | 1.5 | 0.0 | 0.8 | -0.4 |
Liver weight, right | 0.6 | 1.0 | 2.7 | 1.0 | 1.4 | -1.4 | 0.6 | 0.3 | -0.3 | -0.5 | 0.5 | -1.1 | -0.6 | -1.3 | -1.1 | -0.4 | -1.6 | -1.6 | 0.1 | -1.6 | -0.3 | -0.8 | 0.2 |
Tibia length | 0.6 | 1.8 | 2.8 | -0.1 | 1.6 | -1.7 | 1.4 | 1.5 | -1.5 | -1.1 | 1.1 | -1.6 | 0.5 | -1.6 | -1.6 | 0.6 | -1.7 | -1.5 | 1.1 | -1.6 | 0.8 | -1.4 | 1.1 |
Delay discounting total patch changes 12 sec | 0.6 | 0.8 | 1.7 | -0.3 | 0.9 | -0.9 | 0.9 | 0.6 | -0.6 | -1.3 | 1.3 | -1.0 | 0.7 | -0.9 | -1.0 | 0.6 | -0.9 | -1.0 | 0.8 | -1.0 | 0.7 | -1.0 | 0.8 |
Std. dev. reaction times | 0.6 | 0.8 | 1.6 | -0.3 | 1.1 | -1.1 | 1.1 | 0.8 | -0.8 | -0.5 | 0.5 | -1.1 | 0.3 | -1.1 | -1.1 | 0.6 | -1.1 | -1.3 | 0.9 | -1.1 | 0.7 | -1.1 | 0.8 |
Social responses | 0.6 | 0.8 | 2.3 | 0.9 | 1.3 | -1.3 | 0.5 | 0.4 | -0.4 | -0.1 | 0.1 | -1.0 | -0.3 | -1.2 | -1.1 | -0.4 | -1.5 | -1.5 | 0.2 | -1.5 | -0.2 | -0.7 | 0.2 |
Intermitt. access day 1 inactive lever presses | 0.6 | 0.7 | 2.0 | 1.4 | 1.0 | -1.1 | 0.2 | -0.1 | 0.1 | -0.1 | 0.1 | -0.6 | -1.0 | -0.9 | -0.7 | -0.9 | -1.3 | -1.2 | -0.4 | -1.0 | -0.7 | -0.3 | -0.4 |
Total zone transitions, hab. session 1 | 0.6 | 0.9 | 1.2 | -0.3 | 1.1 | -1.1 | 1.0 | 0.8 | -0.8 | -1.0 | 1.0 | -1.1 | 0.6 | -1.1 | -1.1 | 0.6 | -1.1 | -1.0 | 0.8 | -1.1 | 0.7 | -1.0 | 0.8 |
Pavlov. Cond. lever latency | 0.6 | 0.8 | 1.3 | 0.9 | -0.6 | 0.6 | -1.0 | -1.0 | 1.0 | 1.1 | -1.1 | 0.8 | -0.8 | 0.7 | 0.7 | -1.0 | 0.5 | 0.5 | -1.0 | 0.5 | -1.1 | 0.9 | -1.0 |
Bone surface | 0.6 | 1.1 | 2.0 | -0.6 | 1.1 | -1.1 | 1.3 | 1.4 | -1.4 | -1.0 | 1.0 | -1.2 | 0.2 | -1.1 | -1.1 | 0.8 | -1.0 | -0.7 | 1.2 | -1.1 | 0.9 | -1.1 | 1.1 |
Bone: maximum moment | 0.6 | 1.0 | 2.7 | -0.3 | -1.4 | 1.4 | -0.9 | -0.4 | 0.4 | 0.7 | -0.7 | 1.2 | -0.1 | 1.3 | 1.2 | -0.2 | 1.5 | 1.7 | -0.5 | 1.5 | -0.3 | 1.1 | -0.6 |
Bone: trabecular thickness | 0.6 | 0.7 | 1.9 | -1.1 | 0.4 | -0.5 | 1.0 | 1.4 | -1.4 | -0.8 | 0.8 | -0.7 | 0.6 | -0.5 | -0.6 | 1.1 | -0.2 | 0.2 | 1.1 | -0.2 | 1.1 | -0.7 | 1.0 |
Run reversals in cocaine runway, females | 0.6 | 0.6 | 2.0 | 0.8 | 1.1 | -1.1 | 0.5 | -0.0 | 0.0 | -0.5 | 0.5 | -0.8 | -0.3 | -1.0 | -0.9 | -0.4 | -1.3 | -1.4 | 0.0 | -1.3 | -0.2 | -0.6 | 0.0 |
Retroperitoneal fat weight | 0.5 | 1.8 | 2.8 | -1.4 | 1.1 | -1.0 | 1.6 | 1.7 | -1.7 | -1.4 | 1.4 | -1.3 | 1.2 | -1.1 | -1.2 | 1.5 | -0.8 | -0.7 | 1.6 | -0.9 | 1.6 | -1.4 | 1.6 |
Reaction time mean minus median | 0.5 | 0.7 | 1.1 | -1.0 | 0.6 | -0.6 | 1.0 | 0.9 | -0.9 | -0.8 | 0.8 | -0.8 | 0.8 | -0.7 | -0.7 | 1.1 | -0.4 | -0.7 | 1.0 | -0.5 | 1.1 | -0.9 | 1.0 |
Reaction time mean minus median AUC | 0.5 | 0.6 | 1.1 | -0.9 | 0.6 | -0.5 | 0.9 | 0.9 | -0.9 | -0.7 | 0.7 | -0.8 | 0.8 | -0.6 | -0.7 | 1.0 | -0.4 | -0.7 | 1.0 | -0.6 | 1.0 | -0.9 | 1.0 |
Intermittent access total infusions | 0.5 | 0.6 | 2.1 | -1.4 | -1.0 | 1.1 | -0.1 | -0.1 | 0.1 | -0.3 | 0.3 | 0.5 | 0.9 | 0.8 | 0.7 | 1.0 | 1.2 | 0.9 | 0.4 | 0.9 | 0.8 | 0.2 | 0.4 |
Intermittent access day 1 locomotion | 0.5 | 0.6 | 1.4 | -0.5 | -1.0 | 1.1 | -0.6 | -0.7 | 0.7 | 0.5 | -0.5 | 0.8 | -0.0 | 1.0 | 0.9 | 0.1 | 1.2 | 1.1 | -0.3 | 1.0 | -0.0 | 0.6 | -0.4 |
Lifetime Intake | 0.5 | 0.6 | 2.6 | -1.6 | -0.7 | 0.8 | 0.2 | 0.2 | -0.2 | -0.5 | 0.5 | 0.3 | 1.0 | 0.6 | 0.4 | 1.2 | 1.1 | 0.6 | 0.7 | 0.7 | 1.0 | -0.1 | 0.6 |
Short access day 1 total infusions | 0.5 | 0.5 | 1.0 | -1.0 | 0.4 | -0.4 | 0.9 | 0.9 | -0.9 | -0.6 | 0.6 | -0.6 | 0.7 | -0.4 | -0.5 | 1.0 | -0.2 | -0.6 | 1.0 | -0.3 | 1.0 | -0.7 | 0.9 |
Stereotopy head waving duration, day 7 | 0.5 | 0.7 | 1.9 | 0.8 | 1.2 | -1.2 | 0.5 | 0.5 | -0.5 | -0.2 | 0.2 | -0.9 | -0.3 | -1.1 | -1.0 | -0.3 | -1.4 | -1.2 | 0.2 | -1.2 | -0.2 | -0.6 | 0.2 |
Total zone transitions, hab. session 2 | 0.5 | 0.7 | 2.0 | 0.8 | 1.2 | -1.2 | 0.6 | 0.2 | -0.2 | -0.4 | 0.4 | -0.9 | -0.5 | -1.1 | -0.9 | -0.4 | -1.3 | -1.2 | 0.1 | -1.4 | -0.2 | -0.6 | 0.1 |
Pavlov. Cond. magazine entry number | 0.5 | 0.6 | 1.5 | -0.3 | -1.0 | 1.0 | -0.8 | -0.6 | 0.6 | 0.7 | -0.7 | 0.9 | 0.3 | 1.0 | 0.9 | -0.0 | 1.1 | 1.1 | -0.4 | 1.2 | -0.1 | 0.7 | -0.4 |
Bone: cortical thickness | 0.5 | 0.6 | 1.2 | -0.9 | 0.5 | -0.5 | 0.8 | 0.9 | -0.9 | -1.1 | 1.1 | -0.6 | 1.1 | -0.6 | -0.6 | 1.0 | -0.4 | -0.2 | 0.9 | -0.2 | 1.0 | -0.7 | 0.9 |
Bone: final force | 0.5 | 0.8 | 1.8 | 0.1 | -1.1 | 1.1 | -0.9 | -0.5 | 0.5 | 0.8 | -0.8 | 1.0 | -0.4 | 1.1 | 1.1 | -0.4 | 1.1 | 1.3 | -0.7 | 1.1 | -0.5 | 1.0 | -0.7 |
Bone: periosteal perimeter | 0.5 | 0.8 | 1.1 | -0.4 | 0.9 | -0.9 | 0.8 | 0.9 | -0.9 | -1.0 | 1.0 | -0.9 | 1.0 | -1.0 | -1.0 | 0.7 | -0.9 | -0.8 | 0.8 | -0.7 | 0.7 | -0.9 | 0.9 |
Run reversals in cocaine runway, males | 0.5 | 0.5 | 2.1 | 1.4 | 0.1 | -0.1 | -0.5 | -0.5 | 0.5 | 0.8 | -0.8 | 0.1 | -1.4 | -0.1 | 0.1 | -1.2 | -0.4 | -0.0 | -0.8 | -0.5 | -1.1 | 0.5 | -0.8 |
Body weight | 0.4 | 1.9 | 2.8 | 0.6 | -1.5 | 1.5 | -1.3 | -1.4 | 1.4 | 1.2 | -1.2 | 1.6 | -1.3 | 1.6 | 1.6 | -1.0 | 1.5 | 1.7 | -1.3 | 1.4 | -1.1 | 1.5 | -1.4 |
Left kidney weight | 0.4 | 1.2 | 3.2 | 1.8 | 1.4 | -1.5 | 0.2 | -0.1 | 0.1 | -0.4 | 0.4 | -0.9 | -0.9 | -1.2 | -1.0 | -1.1 | -1.8 | -1.7 | -0.4 | -1.7 | -0.9 | -0.5 | -0.4 |
Length without tail | 0.4 | 0.9 | 1.4 | -0.4 | 1.0 | -1.0 | 1.1 | 0.8 | -0.8 | -1.2 | 1.2 | -1.1 | 0.3 | -1.0 | -1.0 | 0.7 | -0.9 | -1.0 | 0.9 | -1.1 | 0.8 | -1.1 | 0.9 |
Liver weight, left | 0.4 | 0.7 | 1.4 | 0.2 | 1.1 | -1.1 | 0.8 | 0.7 | -0.7 | -0.8 | 0.8 | -1.0 | 0.2 | -1.1 | -1.0 | 0.2 | -1.2 | -1.0 | 0.5 | -1.1 | 0.3 | -0.8 | 0.6 |
Tibialis anterior weight | 0.4 | 1.3 | 5.0 | -2.2 | -0.5 | 0.5 | 0.7 | 0.8 | -0.8 | -1.2 | 1.2 | -0.0 | 1.8 | 0.4 | 0.1 | 1.8 | 0.9 | 0.9 | 1.2 | 0.9 | 1.7 | -0.5 | 1.2 |
Light reinforcement 1 | 0.4 | 0.8 | 1.7 | 0.2 | 1.2 | -1.1 | 0.8 | 0.5 | -0.5 | -1.0 | 1.0 | -1.0 | 0.1 | -1.1 | -1.1 | 0.2 | -1.2 | -1.3 | 0.6 | -1.3 | 0.3 | -0.9 | 0.6 |
Pavlov. Cond. change in total contacts | 0.4 | 0.6 | 1.6 | 1.3 | 0.9 | -1.0 | 0.2 | 0.1 | -0.1 | 0.3 | -0.3 | -0.6 | -1.0 | -0.8 | -0.7 | -0.8 | -1.2 | -0.9 | -0.3 | -1.2 | -0.7 | -0.2 | -0.3 |
Progressive ratio test 1 active lever presses | 0.4 | 0.5 | 0.9 | -1.0 | 0.3 | -0.3 | 0.8 | 0.5 | -0.5 | -0.8 | 0.8 | -0.6 | 0.6 | -0.4 | -0.5 | 1.0 | -0.1 | -0.4 | 0.9 | -0.4 | 0.9 | -0.7 | 0.8 |
Locomotion velocity, session 2 | 0.4 | 0.5 | 1.3 | 0.3 | 1.0 | -1.0 | 0.7 | 0.4 | -0.4 | -0.3 | 0.3 | -0.9 | -0.0 | -1.0 | -0.9 | 0.0 | -1.1 | -1.1 | 0.4 | -1.1 | 0.1 | -0.7 | 0.4 |
Locomotion distance, session 2 | 0.4 | 0.6 | 2.3 | 1.5 | 0.8 | -0.8 | -0.1 | -0.4 | 0.4 | 0.4 | -0.4 | -0.4 | -1.0 | -0.7 | -0.5 | -1.1 | -1.1 | -1.0 | -0.6 | -1.1 | -0.9 | -0.0 | -0.5 |
Condit. Reinf. lever presses | 0.4 | 0.5 | 1.3 | 0.6 | 1.0 | -1.0 | 0.5 | 0.3 | -0.3 | -0.6 | 0.6 | -0.8 | -0.2 | -0.9 | -0.8 | -0.2 | -1.2 | -1.1 | 0.2 | -1.2 | -0.1 | -0.6 | 0.2 |
Pavlov. Cond. magazine entry latency | 0.4 | 0.5 | 1.5 | 0.8 | 1.0 | -1.0 | 0.5 | 0.2 | -0.2 | -0.3 | 0.3 | -0.8 | -0.7 | -0.9 | -0.8 | -0.4 | -1.1 | -1.0 | 0.1 | -1.2 | -0.2 | -0.5 | 0.1 |
Pavlov. Cond. intertrial magazine entries | 0.4 | 0.5 | 1.7 | -1.3 | -0.0 | 0.1 | 0.6 | 0.8 | -0.8 | -0.7 | 0.7 | -0.3 | 1.0 | -0.0 | -0.2 | 1.1 | 0.3 | 0.2 | 0.9 | 0.3 | 1.1 | -0.5 | 0.8 |
Pavlov. Cond. response bias | 0.4 | 0.6 | 1.2 | 0.1 | 0.9 | -1.0 | 0.8 | 0.6 | -0.6 | -0.7 | 0.7 | -0.9 | -0.1 | -0.9 | -0.9 | 0.2 | -1.0 | -1.0 | 0.5 | -1.1 | 0.3 | -0.7 | 0.5 |
Bone: apparent density | 0.4 | 0.6 | 1.2 | -0.7 | 0.6 | -0.6 | 1.1 | 1.1 | -1.1 | -0.6 | 0.6 | -0.9 | 0.2 | -0.7 | -0.7 | 0.8 | -0.5 | -0.3 | 1.0 | -0.7 | 0.8 | -0.8 | 0.9 |
Bone: final moment | 0.4 | 0.7 | 1.9 | -0.2 | -1.1 | 1.2 | -0.8 | -0.4 | 0.4 | 0.6 | -0.6 | 1.0 | -0.2 | 1.1 | 1.0 | -0.2 | 1.2 | 1.4 | -0.5 | 1.2 | -0.3 | 0.9 | -0.5 |
Bone: trabecular spacing | 0.4 | 0.5 | 1.3 | 0.2 | -0.8 | 0.8 | -0.9 | -1.2 | 1.2 | 0.4 | -0.4 | 0.9 | 0.1 | 0.8 | 0.8 | -0.4 | 0.7 | 0.5 | -0.7 | 0.8 | -0.5 | 0.7 | -0.7 |
Delay disc. indifference point, 24s delay | 0.4 | 0.4 | 1.0 | 0.4 | 0.9 | -0.9 | 0.5 | 0.4 | -0.4 | -0.2 | 0.2 | -0.7 | -0.1 | -0.8 | -0.8 | -0.1 | -1.0 | -1.0 | 0.2 | -1.0 | 0.0 | -0.6 | 0.2 |
Mean time between licks in bursts | 0.3 | 0.4 | 0.9 | 0.5 | -0.7 | 0.6 | -0.7 | -0.9 | 0.9 | 0.3 | -0.3 | 0.7 | -0.8 | 0.7 | 0.7 | -0.6 | 0.6 | 0.6 | -0.7 | 0.5 | -0.7 | 0.7 | -0.7 |
Light reinforcement 2 | 0.3 | 0.4 | 0.9 | -0.8 | 0.3 | -0.3 | 0.7 | 0.6 | -0.6 | -0.9 | 0.9 | -0.4 | 0.6 | -0.3 | -0.3 | 0.8 | -0.1 | -0.1 | 0.7 | -0.2 | 0.8 | -0.6 | 0.7 |
Reaction time omissions | 0.3 | 0.5 | 1.2 | 1.1 | 0.9 | -0.9 | 0.2 | -0.0 | 0.0 | 0.2 | -0.2 | -0.6 | -0.8 | -0.8 | -0.7 | -0.6 | -1.1 | -1.1 | -0.2 | -1.1 | -0.5 | -0.3 | -0.2 |
Reaction time premature initiation rate | 0.3 | 0.4 | 0.9 | 0.1 | 0.8 | -0.8 | 0.4 | 0.6 | -0.6 | -0.9 | 0.9 | -0.7 | 0.6 | -0.8 | -0.8 | 0.2 | -0.9 | -0.9 | 0.3 | -0.7 | 0.2 | -0.6 | 0.4 |
Reaction time premature initiations | 0.3 | 0.4 | 0.9 | -0.1 | 0.6 | -0.6 | 0.4 | 0.4 | -0.4 | -1.0 | 1.0 | -0.6 | 0.8 | -0.6 | -0.6 | 0.3 | -0.7 | -0.8 | 0.4 | -0.5 | 0.4 | -0.6 | 0.5 |
Conditioned locomotion | 0.3 | 0.3 | 1.2 | -1.1 | -0.3 | 0.3 | 0.2 | 0.6 | -0.6 | -0.2 | 0.2 | 0.1 | 1.1 | 0.2 | 0.1 | 0.8 | 0.5 | 0.4 | 0.6 | 0.6 | 0.8 | -0.1 | 0.6 |
Pavlov. Cond. magazine entry number | 0.3 | 0.4 | 1.3 | -1.2 | -0.7 | 0.8 | -0.2 | 0.0 | -0.0 | -0.1 | 0.1 | 0.5 | 1.1 | 0.6 | 0.5 | 0.8 | 0.9 | 0.7 | 0.3 | 1.0 | 0.7 | 0.2 | 0.3 |
Intermitt. access day 15 inactive lever presses | 0.3 | 0.3 | 0.6 | 0.6 | 0.7 | -0.8 | 0.4 | 0.4 | -0.4 | -0.6 | 0.6 | -0.6 | -0.5 | -0.6 | -0.6 | -0.3 | -0.8 | -0.7 | 0.1 | -0.7 | -0.2 | -0.4 | 0.1 |
Stereotopy head waving duration, day 3 | 0.3 | 0.3 | 1.2 | 1.1 | -0.0 | -0.0 | -0.6 | -0.7 | 0.7 | 0.5 | -0.5 | 0.3 | -0.7 | 0.1 | 0.2 | -1.0 | -0.2 | -0.1 | -0.8 | -0.1 | -0.9 | 0.5 | -0.7 |
Locomotion distance, session 7 | 0.3 | 0.4 | 1.2 | -1.1 | 0.2 | -0.2 | 0.8 | 0.8 | -0.8 | -0.6 | 0.6 | -0.5 | 0.5 | -0.3 | -0.4 | 1.0 | 0.1 | -0.0 | 1.0 | -0.2 | 1.0 | -0.6 | 0.9 |
Degree of sensitization distance | 0.3 | 0.3 | 0.6 | -0.1 | -0.7 | 0.7 | -0.4 | -0.7 | 0.7 | 0.7 | -0.7 | 0.5 | -0.4 | 0.7 | 0.6 | -0.1 | 0.8 | 0.5 | -0.3 | 0.5 | -0.2 | 0.5 | -0.3 |
Degree of sensitization stereotypy | 0.3 | 0.3 | 0.5 | -0.0 | 0.7 | -0.7 | 0.5 | 0.7 | -0.7 | -0.4 | 0.4 | -0.6 | 0.3 | -0.7 | -0.7 | 0.2 | -0.7 | -0.6 | 0.4 | -0.6 | 0.3 | -0.5 | 0.4 |
Condit. Reinf. inactive responses | 0.3 | 0.3 | 1.0 | -0.4 | -0.8 | 0.8 | -0.4 | -0.3 | 0.3 | 0.0 | -0.0 | 0.6 | 0.1 | 0.7 | 0.7 | 0.1 | 0.9 | 0.9 | -0.2 | 1.0 | 0.0 | 0.5 | -0.2 |
Total zone transitions, NPP test | 0.3 | 0.4 | 1.4 | 1.2 | 0.5 | -0.5 | -0.1 | -0.5 | 0.5 | 0.2 | -0.2 | -0.3 | -1.0 | -0.4 | -0.3 | -0.9 | -0.7 | -0.7 | -0.5 | -0.9 | -0.8 | 0.0 | -0.5 |
Pavlov. Cond. change in total contacts | 0.3 | 0.3 | 0.7 | -0.4 | 0.5 | -0.5 | 0.7 | 0.5 | -0.5 | -0.9 | 0.9 | -0.5 | 0.3 | -0.5 | -0.5 | 0.5 | -0.4 | -0.4 | 0.5 | -0.5 | 0.5 | -0.6 | 0.5 |
Pavlov. Cond. index score | 0.3 | 0.4 | 0.6 | -0.2 | 0.7 | -0.7 | 0.7 | 0.6 | -0.6 | -0.8 | 0.8 | -0.7 | 0.1 | -0.7 | -0.7 | 0.4 | -0.6 | -0.7 | 0.6 | -0.8 | 0.4 | -0.7 | 0.5 |
Pavlov. Cond. latency score | 0.3 | 0.4 | 0.7 | -0.1 | 0.7 | -0.7 | 0.7 | 0.5 | -0.5 | -0.7 | 0.7 | -0.7 | 0.1 | -0.7 | -0.7 | 0.3 | -0.7 | -0.7 | 0.5 | -0.8 | 0.4 | -0.6 | 0.5 |
Pavlov. Cond. lever contacts | 0.3 | 0.4 | 0.6 | -0.7 | 0.4 | -0.4 | 0.7 | 0.7 | -0.7 | -0.8 | 0.8 | -0.6 | 0.7 | -0.5 | -0.5 | 0.8 | -0.3 | -0.4 | 0.8 | -0.4 | 0.8 | -0.7 | 0.7 |
Pavlov. Cond. lever-magazine prob. diff. | 0.3 | 0.4 | 0.7 | -0.1 | 0.7 | -0.7 | 0.7 | 0.5 | -0.5 | -0.7 | 0.7 | -0.7 | -0.0 | -0.7 | -0.7 | 0.3 | -0.7 | -0.7 | 0.5 | -0.8 | 0.4 | -0.7 | 0.5 |
Delta time in closed arm before/after self-admin | 0.3 | 0.3 | 0.7 | 0.7 | -0.4 | 0.4 | -0.6 | -0.4 | 0.4 | 0.5 | -0.5 | 0.4 | -0.9 | 0.3 | 0.4 | -0.7 | 0.2 | -0.0 | -0.6 | 0.2 | -0.8 | 0.6 | -0.6 |
Delta time in open arm before/after self-admin | 0.3 | 0.3 | 0.6 | 0.5 | -0.4 | 0.4 | -0.7 | -0.8 | 0.8 | 0.4 | -0.4 | 0.6 | -0.0 | 0.4 | 0.5 | -0.6 | 0.3 | 0.4 | -0.7 | 0.5 | -0.6 | 0.5 | -0.6 |
Diff in mean of infusions in LGA sessions | 0.3 | 0.3 | 0.9 | -1.0 | 0.1 | -0.0 | 0.5 | 0.3 | -0.3 | -0.7 | 0.7 | -0.3 | 0.9 | -0.1 | -0.2 | 0.9 | 0.1 | -0.2 | 0.7 | 0.1 | 0.8 | -0.5 | 0.7 |
Ambulatory time after self-admin | 0.3 | 0.3 | 0.8 | -0.8 | 0.2 | -0.1 | 0.5 | 0.4 | -0.4 | -0.8 | 0.8 | -0.3 | 0.9 | -0.2 | -0.3 | 0.8 | -0.1 | -0.7 | 0.6 | 0.0 | 0.7 | -0.5 | 0.6 |
Total resting periods, locomotor time 1 | 0.3 | 0.3 | 1.0 | -0.6 | -0.8 | 0.9 | -0.3 | -0.3 | 0.3 | 0.0 | -0.0 | 0.6 | 0.1 | 0.8 | 0.7 | 0.3 | 1.0 | 1.0 | -0.0 | 0.9 | 0.2 | 0.4 | -0.1 |
Total resting periods, locomotor time 2 | 0.3 | 0.3 | 0.8 | 0.4 | 0.8 | -0.8 | 0.5 | 0.4 | -0.4 | -0.3 | 0.3 | -0.7 | -0.1 | -0.8 | -0.7 | -0.1 | -0.9 | -0.8 | 0.2 | -0.9 | 0.0 | -0.5 | 0.2 |
Weight adjusted by age | 0.3 | 0.3 | 0.8 | -0.4 | 0.5 | -0.5 | 0.6 | 0.3 | -0.3 | -0.9 | 0.9 | -0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.4 | -0.5 | 0.5 | -0.3 | 0.5 | -0.6 | 0.5 |
Mg content in liver | 0.3 | 0.3 | 0.6 | 0.3 | 0.7 | -0.7 | 0.4 | 0.4 | -0.4 | -0.4 | 0.4 | -0.6 | 0.0 | -0.7 | -0.7 | -0.0 | -0.8 | -0.8 | 0.2 | -0.8 | 0.0 | -0.5 | 0.3 |
Epididymis fat weight | 0.2 | 0.5 | 0.8 | -0.5 | 0.8 | -0.7 | 0.9 | 0.7 | -0.7 | -0.6 | 0.6 | -0.9 | 0.4 | -0.8 | -0.8 | 0.7 | -0.7 | -0.8 | 0.8 | -0.7 | 0.7 | -0.9 | 0.8 |
Tail length | 0.2 | 0.7 | 3.4 | 1.8 | 0.6 | -0.7 | -0.3 | -0.3 | 0.3 | 0.6 | -0.6 | -0.1 | -1.5 | -0.5 | -0.3 | -1.4 | -1.0 | -0.3 | -0.9 | -0.9 | -1.3 | 0.3 | -0.9 |
Parametrial fat weight | 0.2 | 0.4 | 1.1 | -1.0 | 0.2 | -0.1 | 0.7 | 0.6 | -0.6 | -1.1 | 1.1 | -0.4 | 0.8 | -0.2 | -0.3 | 1.0 | 0.0 | -0.1 | 0.8 | -0.0 | 0.9 | -0.6 | 0.8 |
Food consumed during 24 hour testing period | 0.2 | 0.2 | 0.3 | -0.5 | 0.4 | -0.4 | 0.5 | 0.6 | -0.6 | -0.5 | 0.5 | -0.4 | 0.6 | -0.3 | -0.4 | 0.5 | -0.3 | -0.2 | 0.5 | -0.2 | 0.6 | -0.5 | 0.5 |
Delay discounting time to switch 0 sec | 0.2 | 0.3 | 1.0 | -0.3 | -0.7 | 0.7 | -0.4 | 0.0 | -0.0 | 1.0 | -1.0 | 0.5 | -0.2 | 0.6 | 0.6 | 0.0 | 0.7 | 0.7 | -0.1 | 0.6 | -0.1 | 0.5 | -0.2 |
Delay discounting water rate 12 sec | 0.2 | 0.2 | 1.0 | 0.5 | -0.2 | 0.2 | -0.4 | -1.0 | 1.0 | 0.0 | -0.0 | 0.3 | -0.5 | 0.3 | 0.3 | -0.5 | 0.2 | -0.2 | -0.6 | 0.0 | -0.5 | 0.3 | -0.6 |
Delay discounting water rate 18 sec | 0.2 | 0.3 | 0.7 | -0.3 | -0.7 | 0.7 | -0.4 | -0.3 | 0.3 | -0.1 | 0.1 | 0.6 | 0.0 | 0.7 | 0.7 | -0.0 | 0.8 | 0.8 | -0.3 | 0.8 | -0.1 | 0.5 | -0.3 |
Reaction time number correct | 0.2 | 0.3 | 0.9 | -0.6 | -0.8 | 0.9 | -0.4 | -0.4 | 0.4 | -0.0 | 0.0 | 0.6 | 0.3 | 0.8 | 0.7 | 0.2 | 0.9 | 0.8 | -0.1 | 0.8 | 0.2 | 0.4 | -0.1 |
Reaction time trials correct on left | 0.2 | 0.3 | 0.9 | -0.6 | -0.8 | 0.9 | -0.4 | -0.4 | 0.4 | -0.0 | 0.0 | 0.6 | 0.3 | 0.8 | 0.7 | 0.2 | 0.9 | 0.8 | -0.1 | 0.8 | 0.2 | 0.4 | -0.1 |
Reaction time trials on left | 0.2 | 0.2 | 0.7 | -0.5 | -0.7 | 0.8 | -0.3 | -0.3 | 0.3 | -0.0 | 0.0 | 0.6 | 0.2 | 0.7 | 0.6 | 0.2 | 0.9 | 0.7 | -0.1 | 0.7 | 0.1 | 0.4 | -0.1 |
Reaction time trials completed | 0.2 | 0.2 | 0.7 | -0.5 | -0.7 | 0.8 | -0.3 | -0.3 | 0.3 | -0.0 | 0.0 | 0.6 | 0.2 | 0.7 | 0.6 | 0.2 | 0.9 | 0.7 | -0.1 | 0.7 | 0.1 | 0.4 | -0.1 |
Reaction time trials AUC | 0.2 | 0.3 | 0.9 | -0.5 | -0.8 | 0.9 | -0.4 | -0.4 | 0.4 | 0.0 | -0.0 | 0.7 | 0.1 | 0.8 | 0.7 | 0.1 | 0.9 | 0.8 | -0.2 | 0.7 | 0.1 | 0.5 | -0.2 |
Condit. Reinf. active-inactive response ratio | 0.2 | 0.2 | 0.6 | 0.7 | 0.3 | -0.4 | 0.0 | -0.3 | 0.3 | 0.6 | -0.6 | -0.2 | -0.8 | -0.3 | -0.2 | -0.5 | -0.4 | -0.4 | -0.2 | -0.6 | -0.4 | -0.1 | -0.3 |
Pavlov. Cond. latency score | 0.2 | 0.2 | 0.9 | 0.9 | 0.2 | -0.2 | -0.3 | -0.1 | 0.1 | 0.5 | -0.5 | 0.0 | -0.8 | -0.1 | -0.0 | -0.8 | -0.4 | -0.1 | -0.5 | -0.3 | -0.7 | 0.3 | -0.5 |
Progressive ratio test 1 breakpoint | 0.2 | 0.2 | 0.6 | -0.8 | 0.0 | 0.0 | 0.5 | 0.2 | -0.2 | -0.4 | 0.4 | -0.3 | 0.4 | -0.1 | -0.1 | 0.7 | 0.1 | -0.2 | 0.6 | -0.1 | 0.7 | -0.4 | 0.5 |
Progressive ratio test 1 inactive lever presses | 0.2 | 0.2 | 0.7 | 0.7 | 0.5 | -0.5 | 0.2 | 0.2 | -0.2 | 0.0 | -0.0 | -0.3 | -0.8 | -0.4 | -0.3 | -0.5 | -0.6 | -0.4 | -0.1 | -0.5 | -0.4 | -0.1 | -0.2 |
Short access day 10 total infusions | 0.2 | 0.3 | 0.8 | -0.9 | -0.7 | 0.8 | -0.1 | -0.1 | 0.1 | -0.4 | 0.4 | 0.4 | 0.6 | 0.6 | 0.5 | 0.6 | 0.9 | 0.4 | 0.2 | 0.7 | 0.5 | 0.2 | 0.2 |
Locomotion distance, session 1 | 0.2 | 0.3 | 1.1 | 1.1 | 0.4 | -0.4 | -0.2 | -0.4 | 0.4 | 0.4 | -0.4 | -0.1 | -0.8 | -0.3 | -0.2 | -0.8 | -0.6 | -0.5 | -0.5 | -0.6 | -0.7 | 0.1 | -0.5 |
Stereotopy head waving bouts, day 3 | 0.2 | 0.3 | 1.2 | 1.1 | 0.4 | -0.4 | -0.3 | -0.3 | 0.3 | 0.2 | -0.2 | -0.1 | -0.6 | -0.3 | -0.2 | -0.8 | -0.6 | -0.4 | -0.5 | -0.5 | -0.8 | 0.1 | -0.5 |
Total locomotion distance, hab. session 1 | 0.2 | 0.2 | 0.3 | -0.5 | 0.4 | -0.4 | 0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.4 | 0.5 | -0.4 | -0.4 | 0.6 | -0.3 | -0.2 | 0.5 | -0.2 | 0.6 | -0.5 | 0.5 |
Novelty place preference | 0.2 | 0.2 | 0.4 | 0.3 | -0.4 | 0.4 | -0.5 | -0.6 | 0.6 | 0.1 | -0.1 | 0.5 | -0.3 | 0.5 | 0.5 | -0.4 | 0.4 | 0.3 | -0.5 | 0.4 | -0.4 | 0.5 | -0.5 |
Time in novel zone, NPP test | 0.2 | 0.2 | 0.3 | 0.1 | -0.5 | 0.5 | -0.5 | -0.5 | 0.5 | -0.0 | 0.0 | 0.5 | -0.1 | 0.5 | 0.5 | -0.2 | 0.5 | 0.4 | -0.4 | 0.5 | -0.3 | 0.4 | -0.4 |
Locomotion velocity, NPP test | 0.2 | 0.3 | 1.2 | 1.1 | 0.1 | -0.1 | -0.3 | -0.7 | 0.7 | 0.4 | -0.4 | 0.1 | -1.1 | -0.0 | 0.1 | -0.9 | -0.3 | -0.3 | -0.6 | -0.5 | -0.8 | 0.3 | -0.6 |
Bone volume | 0.2 | 0.3 | 0.8 | -0.4 | 0.5 | -0.5 | 0.8 | 0.9 | -0.9 | -0.5 | 0.5 | -0.7 | -0.1 | -0.5 | -0.5 | 0.5 | -0.4 | -0.2 | 0.7 | -0.5 | 0.5 | -0.6 | 0.6 |
Bone: cortical porosity | 0.2 | 0.2 | 0.6 | 0.4 | -0.4 | 0.4 | -0.4 | -0.6 | 0.6 | 0.3 | -0.3 | 0.4 | -0.8 | 0.4 | 0.4 | -0.5 | 0.4 | 0.4 | -0.5 | 0.2 | -0.5 | 0.5 | -0.5 |
Bone: endosteal perimeter | 0.2 | 0.5 | 0.9 | -0.6 | 0.6 | -0.6 | 0.7 | 0.8 | -0.8 | -0.9 | 0.9 | -0.7 | 0.9 | -0.6 | -0.7 | 0.7 | -0.6 | -0.4 | 0.7 | -0.4 | 0.7 | -0.7 | 0.8 |
Sum of active levers in priming session hrs 5-6 | 0.2 | 0.2 | 0.4 | -0.5 | -0.6 | 0.6 | -0.2 | 0.1 | -0.1 | 0.4 | -0.4 | 0.4 | 0.2 | 0.5 | 0.4 | 0.2 | 0.6 | 0.3 | 0.0 | 0.6 | 0.1 | 0.3 | 0.0 |
Area under the delay curve | 0.2 | 0.2 | 0.3 | -0.5 | 0.2 | -0.2 | 0.4 | 0.5 | -0.5 | -0.5 | 0.5 | -0.3 | 0.5 | -0.3 | -0.3 | 0.5 | -0.2 | -0.4 | 0.5 | -0.1 | 0.5 | -0.4 | 0.4 |
Delay disc. indifference point, 2s delay | 0.2 | 0.3 | 0.8 | -0.9 | -0.7 | 0.7 | -0.1 | 0.1 | -0.1 | -0.3 | 0.3 | 0.4 | 0.5 | 0.6 | 0.5 | 0.5 | 0.9 | 0.5 | 0.2 | 0.9 | 0.4 | 0.2 | 0.2 |
Delay disc. indifference point, 8s delay | 0.2 | 0.2 | 0.4 | 0.0 | 0.6 | -0.7 | 0.5 | 0.5 | -0.5 | -0.7 | 0.7 | -0.5 | 0.2 | -0.6 | -0.5 | 0.2 | -0.6 | -0.5 | 0.3 | -0.5 | 0.2 | -0.5 | 0.3 |
Bouts of movement, locomotor time 2 | 0.2 | 0.3 | 0.7 | 0.3 | 0.7 | -0.8 | 0.4 | 0.3 | -0.3 | -0.3 | 0.3 | -0.6 | -0.0 | -0.7 | -0.6 | -0.0 | -0.8 | -0.7 | 0.2 | -0.8 | 0.0 | -0.5 | 0.2 |
Locomotion in novel chamber | 0.2 | 0.3 | 1.1 | 0.8 | -0.0 | -0.0 | -0.4 | -0.6 | 0.6 | 1.0 | -1.0 | 0.3 | -0.5 | 0.1 | 0.2 | -0.7 | -0.1 | 0.1 | -0.6 | -0.1 | -0.6 | 0.3 | -0.6 |
Seeking ratio, punishment vs. effort | 0.2 | 0.3 | 1.0 | -1.0 | 0.1 | 0.0 | 0.6 | 0.6 | -0.6 | -0.4 | 0.4 | -0.4 | 0.5 | -0.1 | -0.2 | 0.9 | 0.1 | -0.4 | 0.8 | -0.2 | 0.9 | -0.5 | 0.7 |
Fe content in liver | 0.2 | 0.3 | 0.4 | 0.0 | -0.6 | 0.7 | -0.4 | -0.6 | 0.6 | 0.4 | -0.4 | 0.6 | -0.5 | 0.6 | 0.6 | -0.2 | 0.7 | 0.6 | -0.4 | 0.5 | -0.3 | 0.5 | -0.4 |
Sr content in liver | 0.2 | 0.2 | 0.4 | 0.1 | 0.6 | -0.6 | 0.4 | 0.4 | -0.4 | -0.5 | 0.5 | -0.5 | 0.2 | -0.6 | -0.5 | 0.1 | -0.6 | -0.5 | 0.3 | -0.6 | 0.2 | -0.5 | 0.3 |
Length with tail | 0.1 | 0.4 | 1.6 | 1.3 | 0.6 | -0.7 | 0.0 | -0.0 | 0.0 | 0.2 | -0.2 | -0.4 | -1.2 | -0.5 | -0.4 | -0.9 | -0.9 | -0.5 | -0.4 | -1.0 | -0.8 | 0.0 | -0.5 |
Number of licking bursts | 0.1 | 0.1 | 0.6 | 0.8 | 0.3 | -0.4 | -0.1 | -0.2 | 0.2 | 0.2 | -0.2 | -0.1 | -0.4 | -0.3 | -0.2 | -0.6 | -0.5 | -0.4 | -0.3 | -0.5 | -0.5 | 0.0 | -0.3 |
Times rat made contact with spout | 0.1 | 0.2 | 0.5 | 0.7 | 0.1 | -0.2 | -0.2 | -0.3 | 0.3 | 0.7 | -0.7 | 0.0 | -0.7 | -0.1 | -0.0 | -0.6 | -0.3 | -0.3 | -0.4 | -0.4 | -0.5 | 0.1 | -0.4 |
Water consumed over 24 hours | 0.1 | 0.1 | 0.6 | 0.4 | -0.2 | 0.2 | -0.3 | -0.2 | 0.2 | 0.8 | -0.8 | 0.3 | -0.4 | 0.3 | 0.3 | -0.4 | 0.1 | 0.2 | -0.4 | 0.1 | -0.4 | 0.3 | -0.4 |
Indifference point 0 sec | 0.1 | 0.2 | 0.4 | -0.7 | -0.0 | 0.1 | 0.3 | 0.4 | -0.4 | -0.7 | 0.7 | -0.2 | 0.6 | -0.0 | -0.1 | 0.6 | 0.1 | -0.1 | 0.5 | 0.0 | 0.5 | -0.3 | 0.4 |
Delay discounting total patch changes 6 sec | 0.1 | 0.2 | 0.5 | -0.5 | -0.6 | 0.7 | -0.2 | -0.3 | 0.3 | -0.3 | 0.3 | 0.5 | 0.2 | 0.6 | 0.5 | 0.3 | 0.7 | 0.6 | -0.0 | 0.5 | 0.2 | 0.3 | -0.1 |
Delay discounting water rate 24 sec | 0.1 | 0.1 | 0.3 | 0.6 | 0.1 | -0.1 | -0.2 | -0.5 | 0.5 | -0.1 | 0.1 | 0.0 | -0.6 | -0.0 | 0.0 | -0.5 | -0.2 | -0.3 | -0.3 | -0.4 | -0.4 | 0.1 | -0.4 |
Delay discounting water rate 6 sec | 0.1 | 0.1 | 0.4 | 0.7 | 0.2 | -0.2 | -0.1 | -0.5 | 0.5 | 0.1 | -0.1 | 0.0 | -0.7 | -0.1 | -0.0 | -0.5 | -0.3 | -0.4 | -0.4 | -0.4 | -0.5 | 0.1 | -0.4 |
Social time | 0.1 | 0.2 | 0.6 | 0.4 | 0.6 | -0.7 | 0.3 | 0.4 | -0.4 | -0.1 | 0.1 | -0.5 | 0.0 | -0.6 | -0.5 | -0.1 | -0.7 | -0.6 | 0.1 | -0.7 | -0.1 | -0.3 | 0.1 |
Condit. Reinf. lever presses | 0.1 | 0.2 | 0.4 | 0.5 | 0.5 | -0.6 | 0.2 | 0.2 | -0.2 | 0.1 | -0.1 | -0.4 | -0.4 | -0.5 | -0.4 | -0.3 | -0.7 | -0.3 | -0.0 | -0.6 | -0.2 | -0.2 | -0.0 |
Pavlov. Cond. magazine entry latency | 0.1 | 0.2 | 0.7 | 0.9 | 0.2 | -0.3 | -0.2 | -0.3 | 0.3 | 0.1 | -0.1 | 0.0 | -0.8 | -0.1 | -0.0 | -0.7 | -0.4 | -0.2 | -0.5 | -0.4 | -0.6 | 0.2 | -0.5 |
Pavlov. Cond. index score | 0.1 | 0.1 | 0.3 | 0.6 | 0.4 | -0.5 | 0.1 | 0.2 | -0.2 | 0.1 | -0.1 | -0.3 | -0.5 | -0.4 | -0.3 | -0.4 | -0.6 | -0.3 | -0.1 | -0.5 | -0.3 | -0.1 | -0.1 |
Pavlov. Cond. lever contacts | 0.1 | 0.1 | 0.5 | 0.7 | 0.1 | -0.1 | -0.2 | -0.0 | 0.0 | 0.5 | -0.5 | 0.0 | -0.6 | -0.1 | 0.0 | -0.6 | -0.2 | 0.0 | -0.4 | -0.2 | -0.5 | 0.2 | -0.4 |
Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 0.4 | 0.6 | 0.4 | -0.5 | 0.1 | 0.2 | -0.2 | 0.1 | -0.1 | -0.3 | -0.6 | -0.4 | -0.3 | -0.4 | -0.6 | -0.3 | -0.1 | -0.6 | -0.4 | -0.1 | -0.1 |
Pavlov. Cond. response bias | 0.1 | 0.1 | 0.7 | 0.7 | 0.1 | -0.2 | -0.1 | -0.0 | 0.0 | 0.4 | -0.4 | -0.0 | -0.8 | -0.1 | -0.0 | -0.6 | -0.3 | -0.1 | -0.3 | -0.3 | -0.5 | 0.2 | -0.3 |
Conditioned reinforcement - inactives | 0.1 | 0.2 | 0.3 | 0.1 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | -0.3 | 0.3 | -0.5 | -0.2 | -0.5 | -0.5 | 0.1 | -0.5 | -0.5 | 0.3 | -0.5 | 0.1 | -0.4 | 0.3 |
Conditioned locomotion | 0.1 | 0.1 | 0.4 | -0.6 | 0.1 | 0.0 | 0.4 | 0.0 | -0.0 | -0.5 | 0.5 | -0.3 | 0.3 | -0.1 | -0.1 | 0.6 | 0.1 | 0.3 | 0.5 | -0.2 | 0.6 | -0.4 | 0.4 |
Intermitt. access escalation Index | 0.1 | 0.1 | 0.1 | 0.2 | -0.2 | 0.2 | -0.3 | -0.3 | 0.3 | 0.0 | -0.0 | 0.3 | -0.2 | 0.3 | 0.3 | -0.3 | 0.2 | 0.2 | -0.3 | 0.2 | -0.3 | 0.3 | -0.3 |
Intermittent access day 1 total infusions | 0.1 | 0.1 | 0.6 | -0.8 | -0.1 | 0.2 | 0.3 | 0.1 | -0.1 | -0.3 | 0.3 | -0.1 | 0.5 | 0.0 | -0.1 | 0.7 | 0.2 | -0.0 | 0.5 | 0.1 | 0.6 | -0.3 | 0.5 |
Cocaine induced anxiety | 0.1 | 0.1 | 0.7 | -0.0 | 0.1 | -0.2 | 0.1 | 0.4 | -0.4 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.8 | 0.1 | 0.1 | 0.1 | -0.0 | 0.1 |
Progressive ratio test 2 inactive lever presses | 0.1 | 0.1 | 0.4 | -0.5 | -0.1 | 0.1 | 0.3 | 0.3 | -0.3 | -0.7 | 0.7 | -0.0 | 0.1 | 0.1 | 0.0 | 0.4 | 0.2 | 0.3 | 0.3 | 0.2 | 0.4 | -0.1 | 0.2 |
Short access day 10 total locomotion | 0.1 | 0.1 | 0.2 | 0.4 | 0.1 | -0.1 | -0.1 | -0.5 | 0.5 | -0.4 | 0.4 | 0.1 | -0.3 | 0.0 | 0.0 | -0.3 | -0.1 | 0.0 | -0.3 | -0.1 | -0.3 | 0.0 | -0.3 |
Locomotion velocity, session 1 | 0.1 | 0.1 | 0.2 | 0.5 | -0.0 | 0.0 | -0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.2 | -0.2 | 0.1 | 0.1 | -0.4 | -0.1 | -0.1 | -0.4 | -0.0 | -0.4 | 0.3 | -0.3 |
Time in familiar zone, hab. session 1 | 0.1 | 0.0 | 0.1 | 0.2 | 0.3 | -0.3 | 0.2 | 0.3 | -0.3 | 0.1 | -0.1 | -0.2 | -0.3 | -0.3 | -0.2 | -0.1 | -0.3 | -0.2 | 0.1 | -0.3 | -0.0 | -0.1 | 0.1 |
Locomotion velocity, hab. session 1 | 0.1 | 0.1 | 0.2 | -0.2 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | -0.3 | 0.3 | -0.4 | 0.4 | -0.4 | -0.4 | 0.3 | -0.4 | -0.3 | 0.4 | -0.3 | 0.4 | -0.4 | 0.4 |
Time in familiar zone, hab. session 2 | 0.1 | 0.1 | 0.7 | 0.4 | -0.1 | 0.1 | -0.3 | -0.5 | 0.5 | 0.9 | -0.9 | 0.2 | -0.3 | 0.1 | 0.2 | -0.4 | 0.0 | -0.0 | -0.3 | 0.0 | -0.4 | 0.2 | -0.3 |
Time in novel zone, hab. session 2 | 0.1 | 0.1 | 0.6 | -0.3 | 0.2 | -0.2 | 0.4 | 0.5 | -0.5 | -0.8 | 0.8 | -0.3 | 0.2 | -0.2 | -0.2 | 0.3 | -0.2 | -0.1 | 0.3 | -0.2 | 0.3 | -0.3 | 0.3 |
Total locomotion distance, NPP test | 0.1 | 0.2 | 0.7 | 0.7 | -0.1 | 0.1 | -0.3 | -0.7 | 0.7 | 0.3 | -0.3 | 0.2 | -0.8 | 0.1 | 0.2 | -0.7 | -0.0 | -0.1 | -0.5 | -0.2 | -0.6 | 0.3 | -0.5 |
Bone: connectivity density | 0.1 | 0.2 | 0.4 | -0.0 | 0.4 | -0.5 | 0.6 | 0.6 | -0.6 | -0.1 | 0.1 | -0.5 | -0.5 | -0.5 | -0.4 | 0.2 | -0.4 | -0.2 | 0.4 | -0.6 | 0.2 | -0.4 | 0.4 |
Bone: cortical porosity | 0.1 | 0.1 | 0.6 | 0.5 | -0.1 | 0.1 | -0.2 | -0.4 | 0.4 | 0.2 | -0.2 | 0.2 | -0.8 | 0.2 | 0.2 | -0.5 | 0.1 | 0.1 | -0.4 | -0.1 | -0.5 | 0.3 | -0.4 |
Bone: elastic work | 0.1 | 0.1 | 0.3 | -0.5 | -0.4 | 0.4 | -0.0 | 0.2 | -0.2 | -0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.3 | 0.5 | 0.5 | 0.2 | 0.5 | 0.3 | 0.1 | 0.1 |
Bone: maximum diameter | 0.1 | 0.2 | 0.6 | 0.5 | 0.6 | -0.6 | 0.1 | -0.1 | 0.1 | -0.3 | 0.3 | -0.4 | 0.1 | -0.6 | -0.5 | -0.3 | -0.8 | -0.6 | -0.1 | -0.6 | -0.2 | -0.3 | 0.0 |
Bone: post-yield work | 0.1 | 0.1 | 0.3 | 0.6 | -0.2 | 0.1 | -0.4 | -0.1 | 0.1 | 0.4 | -0.4 | 0.3 | -0.4 | 0.2 | 0.2 | -0.5 | 0.0 | 0.4 | -0.4 | 0.1 | -0.5 | 0.4 | -0.4 |
Extinction: sum of active levers before priming | 0.1 | 0.1 | 0.3 | -0.5 | -0.0 | 0.1 | 0.2 | 0.5 | -0.5 | -0.5 | 0.5 | -0.1 | 0.3 | -0.1 | -0.1 | 0.4 | 0.1 | -0.1 | 0.4 | 0.0 | 0.4 | -0.1 | 0.3 |
Time in open arm before self-admin | 0.1 | 0.1 | 0.4 | 0.3 | 0.0 | 0.0 | -0.1 | -0.1 | 0.1 | 0.6 | -0.6 | -0.0 | -0.5 | -0.0 | -0.0 | -0.3 | -0.1 | -0.3 | -0.1 | -0.2 | -0.3 | 0.1 | -0.1 |
Time in open arm after self-admin | 0.1 | 0.1 | 0.4 | 0.2 | -0.1 | 0.1 | -0.3 | -0.2 | 0.2 | 0.6 | -0.6 | 0.2 | 0.1 | 0.1 | 0.1 | -0.2 | 0.1 | -0.1 | -0.2 | 0.1 | -0.2 | 0.2 | -0.2 |
Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.7 | 0.5 | 0.5 | -0.5 | 0.2 | -0.2 | 0.2 | -0.1 | 0.1 | -0.4 | -0.4 | -0.4 | -0.4 | -0.3 | -0.6 | -0.8 | -0.1 | -0.6 | -0.2 | -0.3 | -0.0 |
Delay disc. indifference point, 4s delay | 0.1 | 0.1 | 0.3 | -0.6 | 0.2 | -0.1 | 0.4 | 0.4 | -0.4 | -0.2 | 0.2 | -0.3 | 0.5 | -0.2 | -0.2 | 0.5 | -0.0 | -0.4 | 0.5 | -0.1 | 0.5 | -0.4 | 0.4 |
Delay discount exponential model param | 0.1 | 0.2 | 0.2 | 0.4 | -0.3 | 0.3 | -0.4 | -0.5 | 0.5 | 0.5 | -0.5 | 0.3 | -0.4 | 0.3 | 0.3 | -0.4 | 0.2 | 0.5 | -0.4 | 0.2 | -0.5 | 0.4 | -0.4 |
Delay discount hyperbolic model param | 0.1 | 0.1 | 0.2 | 0.5 | -0.1 | 0.1 | -0.3 | -0.4 | 0.4 | 0.4 | -0.4 | 0.2 | -0.4 | 0.1 | 0.2 | -0.4 | 0.0 | 0.3 | -0.4 | -0.0 | -0.4 | 0.3 | -0.4 |
Fecal boli incidents, locomotor time 1 | 0.1 | 0.1 | 0.5 | 0.6 | 0.5 | -0.5 | 0.0 | -0.0 | 0.0 | -0.3 | 0.3 | -0.3 | -0.2 | -0.4 | -0.4 | -0.4 | -0.6 | -0.7 | -0.1 | -0.6 | -0.3 | -0.1 | -0.1 |
Bouts of movement, locomotor time 1 | 0.1 | 0.1 | 0.5 | -0.7 | -0.4 | 0.4 | 0.1 | 0.1 | -0.1 | -0.3 | 0.3 | 0.2 | 0.3 | 0.3 | 0.3 | 0.5 | 0.6 | 0.6 | 0.3 | 0.5 | 0.4 | 0.0 | 0.3 |
Vertical activity count, locomotor time 2 | 0.1 | 0.1 | 0.4 | 0.5 | -0.0 | 0.0 | -0.2 | -0.5 | 0.5 | 0.2 | -0.2 | 0.1 | -0.7 | 0.0 | 0.1 | -0.4 | -0.1 | -0.2 | -0.3 | -0.2 | -0.4 | 0.2 | -0.3 |
Cu content in liver | 0.1 | 0.1 | 0.6 | -0.8 | -0.4 | 0.4 | 0.2 | 0.3 | -0.3 | -0.1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.2 | 0.5 | 0.6 | 0.6 | 0.4 | 0.4 | 0.5 | 0.0 | 0.3 |
Mn content in liver | 0.1 | 0.2 | 0.4 | 0.2 | 0.5 | -0.5 | 0.4 | 0.5 | -0.5 | -0.2 | 0.2 | -0.5 | -0.2 | -0.5 | -0.5 | 0.0 | -0.6 | -0.4 | 0.3 | -0.6 | 0.1 | -0.4 | 0.2 |
Intraocular pressure | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | -0.0 | -0.0 | -0.1 | 0.1 | 0.2 | -0.2 | 0.1 | -0.1 | 0.1 | 0.1 | -0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.0 | 0.0 | -0.1 |
Mean num. licks in bursts | 0.0 | 0.0 | 0.1 | -0.3 | 0.0 | 0.0 | 0.2 | 0.2 | -0.2 | 0.1 | -0.1 | -0.1 | 0.0 | -0.0 | -0.0 | 0.2 | 0.1 | -0.0 | 0.2 | -0.1 | 0.2 | -0.1 | 0.2 |
Delay discounting total patch changes 0 sec | 0.0 | 0.1 | 0.2 | -0.5 | -0.3 | 0.4 | -0.1 | 0.0 | -0.0 | -0.3 | 0.3 | 0.2 | 0.4 | 0.3 | 0.2 | 0.3 | 0.4 | 0.2 | 0.1 | 0.3 | 0.3 | 0.1 | 0.1 |
Delay discounting water rate 0 sec | 0.0 | 0.1 | 0.3 | 0.3 | 0.2 | -0.2 | 0.1 | -0.2 | 0.2 | -0.5 | 0.5 | -0.1 | -0.2 | -0.2 | -0.1 | -0.2 | -0.3 | -0.2 | -0.1 | -0.3 | -0.2 | -0.1 | -0.1 |
Pavlov. Cond. lever latency | 0.0 | 0.1 | 0.2 | -0.1 | -0.3 | 0.3 | -0.2 | -0.5 | 0.5 | -0.2 | 0.2 | 0.3 | -0.0 | 0.3 | 0.3 | 0.0 | 0.3 | 0.2 | -0.1 | 0.3 | -0.0 | 0.2 | -0.2 |
Intermittent access standard deviation | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 | -0.4 | 0.4 | 0.1 | -0.2 | 0.1 | 0.1 | 0.1 | 0.2 | -0.2 | 0.0 | 0.1 | 0.1 | 0.0 | -0.0 |
Time in novel zone, hab. session 1 | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | -0.2 | 0.2 | -0.3 | 0.3 | 0.1 | 0.2 | 0.1 | 0.1 | 0.0 | 0.1 | 0.0 | -0.1 | 0.1 | 0.0 | 0.0 | -0.0 |
Novel to familiar place preference ratio | 0.0 | 0.0 | 0.1 | -0.0 | -0.1 | 0.1 | -0.1 | -0.2 | 0.2 | -0.3 | 0.3 | 0.1 | 0.1 | 0.1 | 0.1 | -0.0 | 0.2 | 0.0 | -0.1 | 0.2 | -0.0 | 0.1 | -0.1 |
Bone: cortical apparent density | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | -0.3 | 0.1 | 0.3 | -0.3 | 0.1 | -0.1 | -0.1 | -0.0 | -0.2 | -0.2 | -0.1 | -0.3 | -0.1 | 0.0 | -0.2 | -0.1 | -0.1 | 0.0 |
Bone: cortical area | 0.0 | 0.0 | 0.1 | 0.1 | -0.2 | 0.2 | -0.3 | -0.1 | 0.1 | 0.1 | -0.1 | 0.2 | 0.1 | 0.2 | 0.2 | -0.2 | 0.2 | 0.3 | -0.2 | 0.3 | -0.2 | 0.3 | -0.2 |
Bone: cortical thickness | 0.0 | 0.1 | 0.1 | 0.2 | -0.2 | 0.2 | -0.3 | -0.1 | 0.1 | 0.3 | -0.3 | 0.2 | -0.0 | 0.2 | 0.2 | -0.3 | 0.1 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | -0.2 |
Bone: cortical tissue density | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | -0.2 | 0.0 | 0.2 | -0.2 | 0.1 | -0.1 | -0.1 | -0.0 | -0.2 | -0.2 | -0.1 | -0.2 | -0.1 | -0.0 | -0.1 | -0.1 | -0.0 | -0.0 |
Bone: endosteal estimation | 0.0 | 0.1 | 0.3 | -0.3 | -0.4 | 0.5 | -0.2 | -0.1 | 0.1 | 0.0 | -0.0 | 0.3 | 0.1 | 0.4 | 0.3 | 0.1 | 0.5 | 0.5 | -0.0 | 0.4 | 0.1 | 0.3 | -0.0 |
Bone: marrow area | 0.0 | 0.1 | 0.2 | -0.3 | -0.4 | 0.4 | -0.1 | -0.0 | 0.0 | -0.0 | 0.0 | 0.2 | 0.2 | 0.3 | 0.3 | 0.2 | 0.4 | 0.5 | 0.0 | 0.4 | 0.1 | 0.2 | 0.0 |
Bone: periosteal estimation | 0.0 | 0.1 | 0.3 | -0.1 | -0.4 | 0.4 | -0.3 | -0.1 | 0.1 | 0.0 | -0.0 | 0.3 | 0.2 | 0.3 | 0.3 | -0.0 | 0.4 | 0.5 | -0.1 | 0.4 | -0.1 | 0.3 | -0.1 |
Time in closed arm before self-admin | 0.0 | 0.1 | 0.3 | 0.0 | -0.2 | 0.1 | -0.0 | -0.3 | 0.3 | -0.0 | 0.0 | 0.2 | -0.3 | 0.3 | 0.3 | -0.1 | 0.3 | 0.5 | -0.2 | 0.2 | -0.1 | 0.2 | -0.2 |
Time to tail flick, test, before self-admin | 0.0 | 0.0 | 0.2 | -0.1 | 0.0 | -0.0 | 0.1 | 0.5 | -0.5 | -0.0 | 0.0 | -0.1 | -0.1 | -0.1 | -0.1 | 0.1 | -0.0 | -0.1 | 0.2 | -0.1 | 0.1 | -0.0 | 0.2 |
Total heroin consumption | 0.0 | 0.1 | 0.2 | -0.4 | -0.3 | 0.3 | -0.1 | -0.1 | 0.1 | -0.2 | 0.2 | 0.3 | 0.2 | 0.3 | 0.3 | 0.2 | 0.4 | 0.3 | 0.0 | 0.4 | 0.2 | 0.1 | -0.0 |
Delay disc. indifference point, 16s delay | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.0 | 0.1 | 0.2 | -0.2 | -0.2 | 0.2 | -0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.0 | -0.3 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.