Hub : Genes

Kank4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000007779	0.17	0.14	7.6e-11	0.07	0.06	0.07	0.06	4.7e-08	1.1e-07	4.2e-08	3.6e-07
2	BLA	gene expression	ENSRNOG00000007779	0.15	0.12	1.3e-07	0.13	0.13	0.12	0.12	2.7e-07	2.3e-07	4.1e-07	4.0e-07
3	Brain	mRNA stability	ENSRNOG00000007779	0.05	0.05	2.5e-04	0.04	0.04	0.04	0.04	1.7e-04	2.1e-04	2.3e-04	2.3e-04
4	NAcc	gene expression	ENSRNOG00000007779	0.03	0.03	8.2e-03	0.02	0.02	0.02	0.02	9.8e-03	6.1e-03	1.4e-02	1.1e-02
5	PL	gene expression	ENSRNOG00000007779	0.09	0.08	3.9e-07	0.08	0.08	0.08	0.08	6.8e-07	7.0e-07	6.8e-07	8.1e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	0.0	0.1	0.2	0.3	0.4	-0.2	0.4	0.3
BMI without tail	0.2	0.4	0.5	0.7	0.7	-0.5	0.7	0.6
Body weight	0.1	0.3	0.4	-0.3	-0.5	0.7	-0.5	-0.6
Epididymis fat weight	2.2	5.1	5.4	-2.2	-2.3	2.3	-2.3	-2.3
Glucose	0.0	0.0	0.1	0.1	0.2	-0.0	0.1	0.3
Heart weight	3.2	4.6	5.0	-2.1	-2.1	2.2	-2.1	-2.2
Left kidney weight	0.3	0.9	1.0	-0.8	-1.0	1.0	-1.0	-1.0
Right kidney weight	0.2	0.5	0.6	-0.6	-0.7	0.7	-0.7	-0.6
Tail length	0.4	1.1	1.4	-0.8	-1.1	1.1	-1.1	-1.2
Length with tail	0.3	1.1	1.3	-0.8	-1.1	1.1	-1.1	-1.1
Length without tail	0.0	0.1	0.1	-0.1	-0.3	0.3	-0.3	-0.2
Liver weight, left	2.1	3.4	3.6	-1.8	-1.8	1.9	-1.8	-1.8
Liver weight, right	6.3	10.5	10.8	-3.3	-3.2	3.3	-3.3	-3.1
Parametrial fat weight	4.8	9.3	9.7	3.0	3.1	-2.9	3.1	3.1
Retroperitoneal fat weight	0.2	0.8	0.9	-0.9	-0.9	0.9	-0.9	-1.0
Intraocular pressure	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	-0.1
Extensor digitorum longus weight	0.6	2.4	2.6	-1.6	-1.6	1.5	-1.6	-1.5
Soleus weight	0.1	0.2	0.3	-0.4	-0.5	0.3	-0.5	-0.5
Tibialis anterior weight	7.9	27.1	27.3	5.2	5.2	-5.2	5.2	5.2
Tibia length	2.3	6.6	7.0	-2.5	-2.6	2.6	-2.6	-2.6
Number of licking bursts	0.0	0.1	0.1	0.3	0.2	-0.2	0.2	0.2
Food consumed during 24 hour testing period	0.2	0.2	0.3	-0.5	-0.5	0.3	-0.5	-0.5
Times rat made contact with spout	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	0.2
Mean time between licks in bursts	6.4	9.0	9.4	-3.1	-3.0	3.0	-3.0	-2.9
Mean num. licks in bursts	0.0	0.0	0.0	-0.2	-0.0	0.1	-0.0	0.1
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	0.1
Water consumed over 24 hours	0.1	0.2	0.2	0.4	0.4	-0.3	0.4	0.4
Indifference point 0 sec	5.8	9.4	9.6	3.1	3.1	-3.1	3.1	3.0
Indifference point AUC	0.8	0.9	1.3	1.1	1.0	-0.7	1.0	1.0
Indifference point function ln k	0.2	0.3	0.3	-0.6	-0.5	0.6	-0.5	-0.5
Indifference point function log k	0.2	0.3	0.3	-0.6	-0.5	0.6	-0.5	-0.5
Delay discounting total patch changes 0 sec	5.3	8.6	8.7	2.9	3.0	-2.9	2.9	2.9
Delay discounting total patch changes 12 sec	0.8	1.1	1.4	1.0	1.0	-1.2	1.0	1.0
Delay discounting total patch changes 18 sec	1.6	2.1	2.4	1.5	1.5	-1.4	1.5	1.4
Delay discounting total patch changes 24 sec	1.5	1.9	2.0	1.4	1.4	-1.3	1.4	1.4
Delay discounting total patch changes 6 sec	2.1	3.2	3.4	1.8	1.7	-1.8	1.7	1.8
Delay discounting time to switch 0 sec	1.5	2.3	2.7	-1.6	-1.6	1.1	-1.6	-1.7
Delay discounting water rate 0 sec	1.6	2.5	2.9	1.7	1.7	-1.3	1.7	1.6
Delay discounting water rate 12 sec	3.5	5.2	5.8	2.4	2.3	-2.0	2.3	2.4
Delay discounting water rate 18 sec	0.2	0.2	0.3	0.5	0.5	-0.4	0.5	0.5
Delay discounting water rate 24 sec	0.0	0.0	0.1	0.3	0.2	-0.0	0.2	0.1
Delay discounting water rate 6 sec	0.1	0.2	0.3	0.5	0.6	-0.0	0.5	0.4
Locomotor activity	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.0	0.0
Locomotor testing distance	1.5	2.4	2.5	1.5	1.6	-1.5	1.6	1.6
Locomotor testing rearing	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	0.0
Light reinforcement 1	0.5	0.9	1.1	-0.9	-1.0	0.9	-1.0	-1.0
Light reinforcement 2	0.4	0.5	0.9	-0.7	-0.6	1.0	-0.6	-0.7
Reaction time number correct	0.1	0.1	0.2	0.5	0.2	-0.3	0.2	0.4
Reaction time mean minus median	0.6	0.7	1.2	0.7	0.7	-1.0	0.7	1.1
Reaction time mean minus median AUC	0.1	0.2	0.3	0.2	0.3	-0.6	0.3	0.6
Reaction time num false alarms	0.2	0.3	0.4	0.6	0.6	-0.4	0.6	0.6
Reaction time num false alarms AUC	0.6	0.9	1.0	1.0	0.9	-0.8	0.9	1.0
Reaction time trials correct on left	0.1	0.1	0.2	0.5	0.2	-0.3	0.2	0.4
Reaction time trials on left	0.1	0.2	0.3	0.5	0.3	-0.4	0.3	0.4
Reaction time mean	0.8	1.1	1.4	0.8	1.0	-1.1	1.0	1.2
Reaction time mean AUC	0.4	0.5	0.8	0.5	0.6	-0.8	0.7	0.9
Median of all reaction times	0.7	1.0	1.2	0.8	1.0	-1.0	1.0	1.1
Reaction time omissions	0.4	0.6	0.7	0.5	0.8	-0.9	0.8	0.8
Reaction time false alarm rate	0.6	0.9	0.9	0.9	1.0	-0.8	1.0	1.0
Reaction time premature initiation rate	0.2	0.3	0.5	-0.7	-0.7	0.3	-0.7	-0.4
Reaction time premature initiations	0.2	0.3	0.6	-0.6	-0.8	0.3	-0.8	-0.3
Std. dev. reaction times	2.1	2.8	3.4	1.5	1.6	-1.8	1.6	1.9
Reaction time trials completed	0.1	0.2	0.3	0.5	0.3	-0.4	0.3	0.4
Reaction time trials AUC	0.1	0.2	0.3	0.5	0.3	-0.4	0.3	0.4
Social response proportion	0.6	0.7	0.8	0.7	0.9	-0.7	0.9	0.9
Social responses	0.8	1.0	1.4	-1.0	-0.9	1.2	-0.9	-0.9
Social time	0.1	0.1	0.3	-0.6	-0.2	0.3	-0.2	-0.2
Conditioned locomotion	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Cocaine response after cond. corrected	0.7	0.8	1.0	1.0	0.9	-0.7	0.9	0.8
Cocaine response after cond. not corrected	0.5	0.6	0.7	0.8	0.8	-0.6	0.8	0.7
Cocaine response before conditioning	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.0	-0.0
Saline control response	0.1	0.2	0.2	-0.4	-0.4	0.3	-0.4	-0.4
Condit. Reinf. active minus inactive responses	1.2	1.5	1.7	-1.3	-1.3	1.1	-1.3	-1.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.6	-0.7	-0.7	0.5	-0.7	-0.7
Condit. Reinf. active responses	0.9	1.2	1.5	-1.2	-1.2	0.8	-1.2	-1.1
Condit. Reinf. inactive responses	1.5	1.9	2.2	-1.5	-1.4	1.2	-1.4	-1.3
Condit. Reinf. lever presses	3.0	4.1	5.0	1.9	2.0	-2.2	2.0	2.0
Condit. Reinf. lever reinforcers received	0.3	0.4	0.6	-0.8	-0.7	0.4	-0.7	-0.6
Pavlov. Cond. lever latency	1.0	1.4	1.7	-1.1	-1.2	1.3	-1.2	-1.2
Pavlov. Cond. magazine entry latency	1.4	1.6	2.1	1.2	1.2	-1.4	1.2	1.3
Pavlov. Cond. change in total contacts	2.0	2.8	3.1	1.6	1.6	-1.8	1.7	1.7
Pavlov. Cond. index score	1.5	2.0	2.5	1.3	1.4	-1.6	1.4	1.4
Pavlov. Cond. latency score	1.2	1.6	2.0	1.2	1.2	-1.4	1.2	1.3
Pavlov. Cond. lever contacts	2.1	2.9	3.6	1.6	1.6	-1.9	1.7	1.8
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	-0.6	-0.6	0.8	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	1.3	1.7	1.8	-1.3	-1.3	1.4	-1.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.3	1.3	1.3	-1.5	1.3	1.4
Pavlov. Cond. response bias	1.6	2.2	2.7	1.3	1.4	-1.6	1.4	1.5
Conditioned reinforcement - actives	0.2	0.2	0.2	-0.4	-0.5	0.4	-0.5	-0.4
Conditioned reinforcement - inactives	0.5	0.6	0.8	-0.5	-0.9	0.7	-0.9	-0.8
Conditioned locomotion	0.1	0.2	0.2	-0.5	-0.4	0.3	-0.4	-0.3
Intermittent access intake day 1-15 change	0.6	0.6	0.8	-0.6	-0.8	0.9	-0.8	-0.9
Intermittent access intake escalation	0.5	0.5	0.6	-0.6	-0.7	0.8	-0.7	-0.7
Intermittent access intake escalation 2	0.6	0.6	0.8	-0.6	-0.7	0.9	-0.7	-0.9
Intermitt. access day 1 inactive lever presses	1.4	1.5	1.9	1.4	1.1	-1.3	1.1	1.2
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.1	-0.7	-1.0	0.9	-1.0	-0.8
Intermitt. access escalation Index	0.9	0.8	0.9	0.6	1.0	-0.9	1.0	0.9
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.1	-0.4	0.3	-0.4	-0.2
Intermittent access day 15 total infusions	0.4	0.4	0.5	-0.5	-0.7	0.7	-0.7	-0.6
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.1	-0.0	-0.3	0.3	-0.3	-0.3
Intermittent access total infusions	0.3	0.3	0.4	-0.4	-0.6	0.6	-0.6	-0.6
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	0.3	-0.4	0.3	0.4
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.3	0.2	-0.3	0.2	0.3
Intermittent access total locomotion	0.1	0.2	0.3	0.6	0.4	-0.3	0.4	0.3
Intermittent access standard deviation	1.4	1.5	1.9	-1.2	-1.1	1.4	-1.1	-1.3
Cocaine induced anxiety	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.4	-0.4
Post-drug Anxiety	1.1	1.3	1.3	-1.1	-1.1	1.1	-1.1	-1.1
Baseline Anxiety	0.5	0.5	0.9	-1.0	-0.6	0.7	-0.6	-0.7
Lifetime Intake	0.1	0.1	0.1	-0.1	-0.3	0.3	-0.3	-0.2
Incentive Sensitization - Responses	0.4	0.4	0.4	0.6	0.6	-0.6	0.6	0.6
Incentive Sensitization - Breakpoint	0.5	0.5	0.6	0.8	0.7	-0.7	0.7	0.7
Progressive ratio test 1 active lever presses	4.2	4.3	4.9	-1.9	-2.2	2.1	-2.2	-2.1
Progressive ratio test 1 breakpoint	5.2	5.3	5.9	-2.1	-2.4	2.3	-2.4	-2.3
Progressive ratio test 1 inactive lever presses	1.7	1.8	2.4	-1.0	-1.5	1.3	-1.5	-1.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	-0.0	-0.4	0.2	-0.4	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.1	-0.4	0.4	-0.4	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.1
Total sessions with >9 infusions	1.4	1.5	1.7	-1.2	-1.3	1.2	-1.3	-1.1
Short access day 1 total inactive lever presses	0.2	0.2	0.4	0.7	0.3	-0.4	0.3	0.4
Short access day 10 total inactive lever presses	2.4	2.7	3.2	1.8	1.5	-1.7	1.5	1.7
Short access day 1 total infusions	0.0	0.0	0.1	0.3	0.1	-0.2	0.1	0.2
Short access day 10 total infusions	0.1	0.1	0.2	0.0	-0.4	0.3	-0.4	-0.3
Short access total infusions	0.0	0.0	0.0	0.1	-0.1	0.0	-0.1	0.0
Short access day 1 locomotion	0.2	0.2	0.2	0.4	0.4	-0.5	0.4	0.4
Short access day 10 total locomotion	0.2	0.3	0.3	0.6	0.5	-0.5	0.5	0.5
Short access total locomotion	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	-0.4
Compulsive drug intake	4.8	4.8	5.2	1.9	2.2	-2.3	2.2	2.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.5	0.1	-0.3	0.1	0.3
One hour access (shock baseline)	2.0	2.3	2.7	-1.3	-1.6	1.5	-1.7	-1.5
Number of responses in last shaping day	0.1	0.1	0.2	-0.2	-0.4	0.2	-0.4	-0.2
Context. condit. distance diff. score	2.7	3.3	3.5	-1.8	-1.9	1.7	-1.9	-1.9
Locomotion velocity, session 1	0.1	0.1	0.2	0.3	0.3	-0.5	0.3	0.4
Locomotion distance, session 1	0.6	0.7	0.8	-0.8	-0.9	0.8	-0.9	-0.9
Locomotion velocity, session 2	0.2	0.3	0.3	0.6	0.6	-0.5	0.6	0.5
Locomotion distance, session 2	0.2	0.3	0.4	0.6	0.4	-0.6	0.4	0.4
Locomotion velocity, session 3	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.0	-0.0
Locomotion distance, session 3	0.0	0.0	0.1	0.0	-0.0	-0.3	-0.0	0.0
Stereotopy head waving bouts, day 3	0.4	0.5	0.7	-0.7	-0.7	0.8	-0.7	-0.7
Stereotopy head waving duration, day 3	0.8	1.0	1.4	-1.0	-0.9	1.2	-0.9	-0.9
Locomotion velocity, session 7	0.4	0.5	0.8	-0.6	-0.6	0.9	-0.6	-0.6
Locomotion distance, session 7	0.4	0.5	0.5	-0.7	-0.6	0.7	-0.6	-0.7
Stereotopy head waving bouts, day 7	1.2	1.3	1.5	1.2	1.1	-1.1	1.1	1.2
Stereotopy head waving duration, day 7	1.2	1.4	1.6	1.2	1.2	-1.2	1.2	1.2
Locomotion velocity, session 8	0.4	0.5	0.6	-0.7	-0.7	0.6	-0.7	-0.8
Locomotion distance, session 8	0.7	1.1	1.3	-1.0	-1.1	0.9	-1.1	-1.1
Degree of sensitization distance	0.0	0.0	0.1	0.2	0.2	0.1	0.2	0.2
Degree of sensitization stereotypy	1.3	1.4	1.6	1.2	1.2	-1.2	1.2	1.3
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	0.1	0.1	-0.2	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.4	-0.3	0.1	-0.3	-0.3
Condit. Reinf. active responses	0.3	0.4	0.5	0.7	0.6	-0.6	0.6	0.6
Condit. Reinf. inactive responses	0.2	0.3	0.4	0.6	0.5	-0.4	0.5	0.5
Incentive salience index mean	0.0	0.0	0.0	0.2	0.1	-0.2	0.2	0.1
Condit. Reinf. lever presses	0.1	0.2	0.2	-0.4	-0.5	0.5	-0.4	-0.4
Time in familiar zone, hab. session 1	2.8	2.7	2.8	-1.6	-1.6	1.6	-1.6	-1.7
Time in novel zone, hab. session 1	7.5	7.3	7.8	2.7	2.7	-2.7	2.7	2.8
Total zone transitions, hab. session 1	1.4	2.0	2.2	-1.4	-1.5	1.2	-1.5	-1.4
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.2	-0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.1	-0.3	-0.3	0.2	-0.3	-0.3
Time in familiar zone, hab. session 2	0.6	0.6	0.7	-0.8	-0.8	0.8	-0.8	-0.8
Time in novel zone, hab. session 2	1.2	1.2	1.3	1.1	1.1	-1.1	1.1	1.1
Total zone transitions, hab. session 2	4.4	5.7	5.9	-2.3	-2.4	2.4	-2.4	-2.4
Total locomotion distance, hab. session 2	1.7	2.3	2.6	-1.5	-1.5	1.6	-1.5	-1.5
Locomotion velocity, hab. session 2	1.4	1.9	2.0	-1.3	-1.4	1.4	-1.4	-1.4
Novel to familiar place preference ratio	1.1	1.2	1.3	1.0	1.1	-1.1	1.1	1.1
Novelty place preference	0.7	0.8	0.9	0.8	0.9	-0.8	0.9	0.9
Time in novel zone, NPP test	1.1	1.2	1.3	1.0	1.1	-1.0	1.1	1.2
Total zone transitions, NPP test	1.6	2.2	2.4	-1.4	-1.5	1.5	-1.5	-1.5
Total locomotion distance, NPP test	0.1	0.2	0.4	-0.3	-0.4	0.6	-0.4	-0.3
Locomotion velocity, NPP test	0.2	0.3	0.5	-0.5	-0.6	0.7	-0.6	-0.6
Pavlov. Cond. lever latency	0.2	0.3	0.4	-0.5	-0.5	0.6	-0.6	-0.5
Pavlov. Cond. magazine entry latency	0.6	0.7	0.9	-0.9	-0.9	0.7	-0.9	-0.9
Pavlov. Cond. change in total contacts	0.3	0.3	0.3	0.6	0.6	-0.6	0.6	0.5
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.0	-0.0
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.0	0.0	-0.2	0.0	-0.0
Pavlov. Cond. magazine entry number	0.8	1.0	1.1	1.0	1.0	-0.9	1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	0.8	-0.9	-0.9	0.9	-0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1	-0.2
Pavlov. Cond. response bias	0.3	0.3	0.4	-0.6	-0.6	0.4	-0.6	-0.6
Bone: apparent density	0.1	0.2	0.2	-0.5	-0.5	0.4	-0.5	-0.4
Bone surface	2.2	3.9	4.0	2.0	2.0	-2.0	2.0	2.0
Bone volume	0.6	1.0	1.1	1.0	1.0	-1.0	1.0	1.0
Bone: connectivity density	1.9	3.0	3.3	1.7	1.7	-1.8	1.7	1.8
Bone: cortical apparent density	8.0	10.5	11.0	-3.2	-3.2	3.3	-3.2	-3.2
Bone: cortical area	0.1	0.2	0.2	0.5	0.4	-0.3	0.4	0.4
Bone: cortical porosity	0.4	0.4	0.5	0.7	0.7	-0.5	0.7	0.6
Bone: cortical porosity	0.6	0.6	0.8	0.9	0.8	-0.6	0.8	0.8
Bone: cortical thickness	0.3	0.5	0.6	-0.7	-0.7	0.8	-0.7	-0.7
Bone: cortical thickness	0.0	0.0	0.0	-0.0	0.0	0.1	0.0	-0.1
Bone: cortical tissue density	7.9	10.3	10.7	-3.2	-3.2	3.3	-3.2	-3.2
Bone: elastic displacement	0.9	1.0	1.1	-1.0	-1.0	1.0	-1.0	-1.0
Bone: elastic work	1.4	1.8	2.2	-1.3	-1.3	1.5	-1.3	-1.4
Bone: endosteal estimation	0.7	1.4	1.6	1.3	1.2	-1.2	1.2	1.1
Bone: endosteal perimeter	1.4	2.9	3.1	1.8	1.7	-1.8	1.7	1.6
Bone: final force	0.4	0.6	0.7	-0.8	-0.7	0.8	-0.8	-0.8
Bone: final moment	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.1	-0.2
Bone: marrow area	0.6	1.3	1.4	1.2	1.1	-1.1	1.1	1.1
Bone: maximum diameter	0.5	0.9	1.1	1.1	1.0	-0.9	1.0	0.9
Bone: maximum force	0.1	0.2	0.3	-0.4	-0.4	0.5	-0.4	-0.5
Bone: maximum moment	0.0	0.1	0.1	0.3	0.3	-0.1	0.3	0.2
Bone: minimum diameter	1.5	2.9	3.5	1.9	1.7	-1.6	1.7	1.6
Bone: periosteal estimation	0.6	1.3	1.5	1.2	1.2	-1.1	1.2	1.1
Bone: periosteal perimeter	0.5	0.9	1.1	1.0	0.9	-0.9	0.9	0.8
Bone: post-yield work	1.7	2.3	2.5	1.6	1.5	-1.6	1.5	1.4
Bone: stiffness	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.4	-0.3
Bone: tissue strength	0.4	0.4	0.5	0.7	0.7	-0.5	0.7	0.6
Bone: trabecular number	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.2	-0.1
Bone: trabecular spacing	0.0	0.0	0.1	-0.2	-0.1	0.3	-0.1	-0.2
Bone: trabecular thickness	0.0	0.1	0.1	-0.2	-0.2	0.3	-0.2	-0.2
Bone: trabecular tissue density	16.6	23.2	23.8	-4.7	-4.8	4.9	-4.8	-4.9
Breakpoint value in progressive ratio session	0.2	0.3	0.5	-0.4	-0.5	0.7	-0.5	-0.5
Distance traveled before self-admin	0.0	0.0	0.1	0.3	0.1	-0.3	0.1	0.2
Distance traveled after self-admin	1.0	1.1	1.5	1.2	0.8	-1.1	0.8	1.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.0	0.4	-0.3	0.4	0.3
Delta time in open arm before/after self-admin	1.8	1.7	2.4	1.5	1.1	-1.5	1.1	1.3
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	-0.3	-0.4	0.3	-0.4	-0.5
Extinction: sum of active levers before priming	0.2	0.2	0.2	-0.4	-0.4	0.4	-0.4	-0.5
Active lever presses in extinction session 6	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.1	0.0
Delta distance traveled before/after self-admin	1.2	1.3	1.8	1.3	1.0	-1.1	1.0	1.2
Delta ambulatory time before/after self-admin	0.8	0.8	1.1	1.1	0.8	-0.9	0.8	1.0
Time in closed arm before self-admin	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.3	-0.3
Time in closed arm after self-admin	0.1	0.1	0.4	-0.7	-0.0	0.3	-0.0	-0.2
Time in open arm before self-admin	0.3	0.3	0.9	0.9	0.5	-0.3	0.5	0.3
Time in open arm after self-admin	3.6	3.9	5.9	2.4	1.7	-2.0	1.7	1.9
Sum of active levers in priming session hrs 5-6	1.5	1.5	1.8	-0.9	-1.2	1.3	-1.2	-1.3
Time to tail flick, vehicle, before self-admin	1.9	1.9	2.2	1.5	1.4	-1.3	1.4	1.3
Time to tail flick, vehicle, after self-admin	1.7	1.8	2.0	1.3	1.4	-1.2	1.4	1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.4	0.4	-0.6	0.4	0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.2	0.3	-0.3	0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	-0.7	-0.4	0.5	-0.5	-0.4
Delta time to tail flick, test, before/after SA	0.2	0.1	0.2	0.3	0.4	-0.4	0.4	0.4
Ambulatory time before self-admin	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.3	-0.2
Ambulatory time after self-admin	0.7	0.8	1.1	1.0	0.7	-1.0	0.7	1.0
Total heroin consumption	0.9	1.0	1.4	-1.1	-0.8	1.2	-0.8	-1.0
Area under the delay curve	0.4	0.4	0.6	-0.7	-0.8	0.6	-0.7	-0.5
Delay disc. indifference point, 0s delay	2.6	2.8	3.3	-1.8	-1.7	1.7	-1.7	-1.5
Delay disc. indifference point, 16s delay	0.8	0.8	1.2	0.8	0.7	-1.0	0.8	1.1
Delay disc. indifference point, 2s delay	0.3	0.3	0.5	-0.7	-0.5	0.5	-0.5	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.4	-0.4	0.2	-0.4	-0.2
Delay disc. indifference point, 4s delay	3.1	3.3	3.6	-1.8	-1.9	1.8	-1.9	-1.8
Delay disc. indifference point, 8s delay	1.7	1.8	2.0	-1.3	-1.4	1.3	-1.4	-1.2
Delay discount exponential model param	0.4	0.5	0.6	0.7	0.8	-0.6	0.8	0.6
Delay discount hyperbolic model param	0.6	0.6	0.7	0.8	0.9	-0.7	0.9	0.7
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.0	0.1	0.1	0.1	0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.2	-0.4	0.4	-0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.2	0.4	0.4	-0.4	0.4	0.4
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.3	0.2	-0.2	0.2	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.4	0.2	-0.3	0.2	0.1
Rest time, locomotor task time 1	0.1	0.1	0.4	0.6	0.2	-0.4	0.2	0.4
Distance moved, locomotor task time 1	0.3	0.4	0.9	-1.0	-0.4	0.5	-0.4	-0.6
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.1	0.4	-0.3	0.4	0.3
Time >=10cm from walls, locomotor time 2	2.8	3.0	3.5	-1.9	-1.6	1.7	-1.6	-1.8
Bouts of movement, locomotor time 2	0.4	0.4	0.5	0.7	0.7	-0.7	0.7	0.4
Total resting periods, locomotor time 2	0.5	0.5	0.7	0.8	0.7	-0.8	0.7	0.5
Rest time, locomotor task time 2	1.2	1.4	2.2	1.5	1.0	-1.2	1.0	1.3
Distance moved, locomotor task time 2	1.9	2.2	3.7	-1.9	-1.3	1.4	-1.3	-1.5
Vertical activity count, locomotor time 2	0.5	0.6	1.1	-1.0	-0.6	0.7	-0.6	-0.7
Weight adjusted by age	2.0	2.3	2.6	1.4	1.6	-1.5	1.6	1.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.3	-0.1	0.1	-0.1	-0.3
Locomotion in novel chamber	1.7	2.1	2.2	1.4	1.4	-1.4	1.4	1.5
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	-0.4	-0.2	0.3	-0.2	-0.4
Progressive ratio	0.2	0.2	0.3	-0.4	-0.4	0.6	-0.4	-0.5
Food seeking constrained by brief footshock	5.2	6.4	7.3	-2.6	-2.3	2.7	-2.3	-2.7
Seeking ratio, punishment vs. effort	1.1	1.4	1.7	-1.3	-1.1	1.2	-1.1	-1.2
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	0.0
Run reversals in cocaine runway, males	0.6	0.5	0.6	0.8	0.6	-0.8	0.6	0.8
Latency to leave start box in cocaine runway	0.3	0.3	0.4	-0.5	-0.6	0.5	-0.6	-0.6
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.2	-0.3
Latency to leave start box in cocaine runway, M	0.3	0.3	0.3	-0.5	-0.6	0.5	-0.6	-0.5
Cd content in liver	1.3	1.4	1.5	1.2	1.2	-1.2	1.2	1.2
Co content in liver	0.1	0.2	0.3	-0.4	-0.4	0.6	-0.4	-0.4
Cu content in liver	0.3	0.4	0.4	-0.6	-0.6	0.6	-0.7	-0.6
Fe content in liver	0.7	0.8	0.8	0.9	0.9	-0.9	0.9	0.9
K content in liver	0.8	0.8	0.9	-0.9	-0.9	1.0	-0.9	-0.8
Mg content in liver	0.5	0.6	0.6	0.7	0.8	-0.6	0.8	0.8
Mn content in liver	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.2	-0.0
Na content in liver	3.2	3.4	3.6	-1.9	-1.8	1.8	-1.8	-1.8
Rb content in liver	0.6	0.8	1.1	-0.9	-0.8	1.0	-0.8	-0.9
Se content in liver	1.1	1.4	1.5	1.2	1.1	-1.2	1.1	1.2
Sr content in liver	0.0	0.0	0.1	0.2	0.2	-0.1	0.2	0.1
Zn content in liver	0.8	0.9	1.0	0.9	1.0	-0.8	1.0	0.9