Hub : Genes

Ehd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000007744	0.24	0.09	4.1e-13	0.12	0.09	0.11	0.1	8.5e-13	2.0e-10	9.0e-12	1.6e-11
2	BLA	gene expression	ENSRNOG00000007744	0.17	0.07	2.5e-06	0.11	0.05	0.06	0.09	1.1e-06	7.5e-04	3.1e-04	1.0e-05
3	Brain	gene expression	ENSRNOG00000007744	0.32	0.12	3.1e-14	0.18	0.15	0.16	0.17	1.1e-16	2.1e-13	4.4e-15	8.8e-16
4	IL	gene expression	ENSRNOG00000007744	0.34	0.15	1.1e-03	0.04	0.06	0.08	0.09	3.2e-02	1.8e-02	6.5e-03	3.6e-03
5	NAcc	gene expression	ENSRNOG00000007744	0.25	0.09	3.9e-13	0.15	0.15	0.16	0.18	1.5e-11	2.8e-11	7.2e-12	1.9e-13
6	OFC	gene expression	ENSRNOG00000007744	0.48	0.13	1.9e-07	0.21	0.27	0.33	0.33	1.2e-05	3.7e-07	1.2e-08	1.6e-08
7	PL	gene expression	ENSRNOG00000007744	0.24	0.07	8.3e-16	0.21	0.21	0.22	0.22	4.7e-16	3.4e-16	2.5e-16	2.2e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	0.1	0.4	1.0	-0.1	0.4	0.1	-1.0	0.8	-0.7	0.7
BMI without tail	0.1	0.2	0.7	-0.5	0.1	0.3	-0.3	0.9	-0.1	0.4
Body weight	0.9	3.8	8.0	-1.6	2.0	1.5	1.2	2.8	1.7	2.3
Epididymis fat weight	4.6	10.8	14.0	-2.9	3.7	2.8	3.1	3.6	3.0	3.7
Glucose	1.2	1.9	3.2	-1.4	1.0	1.3	1.8	1.0	1.7	1.2
Heart weight	4.3	6.1	7.7	-2.5	2.5	2.7	2.1	2.8	2.1	2.6
Left kidney weight	0.1	0.4	1.4	0.2	0.4	-0.6	1.2	-0.1	0.8	0.4
Right kidney weight	1.0	2.8	4.7	-1.1	1.8	0.9	2.2	1.4	2.1	1.9
Tail length	0.9	2.6	4.8	-1.3	1.2	1.1	2.1	1.7	2.2	1.2
Length with tail	1.9	7.1	9.3	-2.3	2.6	2.1	2.9	2.9	3.0	2.6
Length without tail	0.3	0.7	1.2	-0.3	1.1	0.5	0.8	0.9	0.9	1.0
Liver weight, left	1.8	3.0	3.6	-1.6	1.7	1.6	1.9	1.6	1.8	1.8
Liver weight, right	6.8	11.3	13.0	-3.1	3.5	3.2	3.4	3.3	3.4	3.6
Parametrial fat weight	0.9	1.7	2.6	-1.5	1.5	1.4	0.9	1.1	0.8	1.6
Retroperitoneal fat weight	9.4	31.2	37.0	-5.5	5.6	5.5	5.3	6.1	5.3	5.8
Intraocular pressure	0.4	0.6	0.8	-0.7	0.9	0.7	-0.7	0.5	-0.7	0.9
Extensor digitorum longus weight	2.9	11.8	14.4	3.8	-3.5	-3.5	-3.7	-2.7	-3.1	-3.5
Soleus weight	2.5	7.3	9.5	2.8	-3.1	-2.7	-2.8	-2.2	-2.1	-2.9
Tibialis anterior weight	3.2	11.0	14.5	3.1	-3.6	-2.9	-3.8	-2.8	-3.5	-3.3
Tibia length	2.1	6.0	10.4	-1.8	2.2	1.9	3.2	2.2	3.1	2.3
Number of licking bursts	0.0	0.0	0.1	-0.2	0.0	0.0	0.2	0.3	0.3	0.1
Food consumed during 24 hour testing period	0.2	0.2	0.5	-0.3	0.2	0.5	0.6	0.2	0.7	0.2
Times rat made contact with spout	2.8	3.2	5.1	2.2	-1.9	-2.3	-0.9	-1.8	-0.6	-2.0
Mean time between licks in bursts	0.4	0.6	1.7	-0.7	1.3	0.5	0.4	0.7	0.4	1.1
Mean num. licks in bursts	2.0	2.4	3.8	2.0	-1.5	-1.8	-0.8	-1.8	-0.9	-1.7
Std. dev. time between licks in bursts	0.7	0.8	1.1	-0.8	1.0	1.0	0.5	1.0	0.9	1.0
Water consumed over 24 hours	0.9	1.1	1.7	1.2	-1.3	-1.1	-0.7	-1.0	-0.5	-1.3
Indifference point 0 sec	0.0	0.1	0.1	0.2	-0.3	-0.3	-0.2	-0.2	-0.3	-0.0
Indifference point AUC	0.8	0.9	2.0	1.2	-0.7	-1.4	-0.8	-0.8	-0.7	-0.8
Indifference point function ln k	0.2	0.2	0.6	-0.5	0.5	0.7	0.5	0.1	0.2	0.6
Indifference point function log k	0.2	0.2	0.6	-0.5	0.5	0.7	0.5	0.1	0.2	0.6
Delay discounting total patch changes 0 sec	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.1	0.0	-0.2	0.1
Delay discounting total patch changes 12 sec	0.0	0.0	0.1	0.1	0.1	-0.2	-0.3	-0.0	-0.2	0.1
Delay discounting total patch changes 18 sec	0.3	0.4	0.8	0.5	-0.9	-0.8	-0.5	-0.4	-0.3	-0.8
Delay discounting total patch changes 24 sec	0.2	0.3	0.7	-0.3	0.5	0.1	0.7	0.6	0.8	0.5
Delay discounting total patch changes 6 sec	0.0	0.1	0.2	0.4	-0.2	-0.5	-0.2	-0.2	-0.2	-0.1
Delay discounting time to switch 0 sec	1.3	2.0	3.1	1.2	-1.6	-1.3	-1.8	-1.0	-1.4	-1.5
Delay discounting water rate 0 sec	0.3	0.5	1.1	-0.5	0.8	0.7	1.0	0.1	0.8	0.7
Delay discounting water rate 12 sec	2.9	4.3	6.3	-2.2	2.1	2.5	2.0	1.8	1.8	2.1
Delay discounting water rate 18 sec	1.2	1.6	3.6	-1.0	0.9	1.1	1.8	0.6	1.9	0.9
Delay discounting water rate 24 sec	1.8	2.5	3.8	-1.2	1.7	1.3	1.6	1.8	2.0	1.5
Delay discounting water rate 6 sec	0.7	1.0	1.3	-1.0	1.1	1.1	1.1	0.8	1.0	0.8
Locomotor activity	0.1	0.2	0.9	-0.2	0.1	0.1	-0.8	-0.1	-1.0	-0.0
Locomotor testing distance	0.6	1.0	2.2	0.5	-0.9	-0.6	-1.4	-0.7	-1.5	-0.9
Locomotor testing rearing	0.3	0.5	1.0	0.4	-1.0	-0.4	-1.0	-0.3	-0.8	-0.8
Light reinforcement 1	3.5	6.4	9.8	2.4	-3.1	-2.1	-2.3	-2.6	-2.2	-2.9
Light reinforcement 2	1.2	1.6	2.8	1.2	-1.2	-0.9	-1.2	-1.7	-1.3	-1.2
Reaction time number correct	0.1	0.2	0.4	-0.3	0.4	0.5	0.6	0.1	0.5	0.3
Reaction time mean minus median	0.2	0.2	0.8	0.2	-0.4	-0.1	-0.6	-0.4	-0.9	-0.6
Reaction time mean minus median AUC	0.3	0.4	0.8	-0.9	0.8	0.8	0.3	0.3	-0.3	0.5
Reaction time num false alarms	0.2	0.3	0.8	-0.2	0.6	0.4	-0.9	0.2	-0.3	0.5
Reaction time num false alarms AUC	0.2	0.2	1.0	-0.1	0.5	0.3	-1.0	0.2	-0.4	0.3
Reaction time trials correct on left	0.1	0.2	0.4	-0.3	0.4	0.5	0.6	0.1	0.5	0.3
Reaction time trials on left	0.1	0.2	0.3	-0.3	0.4	0.5	0.6	0.1	0.5	0.4
Reaction time mean	0.5	0.7	1.4	-1.2	1.0	1.1	0.2	0.7	-0.2	0.7
Reaction time mean AUC	0.7	0.9	2.0	-1.4	1.1	1.3	0.4	0.9	0.1	0.8
Median of all reaction times	0.8	1.0	2.2	-1.5	1.2	1.4	0.3	0.9	-0.1	0.9
Reaction time omissions	1.1	1.4	2.4	-1.5	1.6	1.4	0.1	1.3	-0.1	1.2
Reaction time false alarm rate	0.1	0.2	1.1	0.1	0.1	0.0	-1.1	0.0	-0.5	0.0
Reaction time premature initiation rate	0.3	0.4	0.8	0.7	-0.6	-0.9	0.1	-0.2	0.5	-0.7
Reaction time premature initiations	0.1	0.2	0.6	0.3	-0.2	-0.4	0.5	0.0	0.8	-0.3
Std. dev. reaction times	0.2	0.2	0.6	-0.7	0.5	0.8	0.1	0.3	-0.3	0.2
Reaction time trials completed	0.1	0.2	0.3	-0.3	0.4	0.5	0.6	0.1	0.5	0.4
Reaction time trials AUC	0.0	0.0	0.1	-0.1	0.1	0.3	0.4	-0.2	0.2	0.1
Social response proportion	0.3	0.3	0.9	0.7	-0.2	-0.9	-0.4	-0.1	-0.5	-0.4
Social responses	0.2	0.3	0.6	0.0	-0.2	-0.1	0.7	0.7	0.8	-0.1
Social time	0.2	0.3	0.6	0.7	-0.4	-0.7	-0.3	-0.3	-0.4	-0.8
Conditioned locomotion	2.4	2.9	3.5	1.8	-1.3	-1.8	-1.9	-1.8	-1.7	-1.5
Cocaine response after cond. corrected	1.5	1.7	3.0	1.1	-1.0	-0.7	-1.6	-1.4	-1.7	-1.3
Cocaine response after cond. not corrected	2.0	2.3	3.2	1.4	-1.3	-1.1	-1.7	-1.6	-1.8	-1.5
Cocaine response before conditioning	0.6	0.7	1.3	1.0	-1.1	-1.0	-0.2	-0.8	-0.0	-0.8
Saline control response	1.3	1.7	3.6	1.2	-1.9	-1.3	-0.2	-1.4	-0.3	-1.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.2	-0.3	-0.2	-0.6	0.1	-0.2	-0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	-0.1	-0.2	-0.3	0.1	0.1	-0.1
Condit. Reinf. active responses	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1	0.2	0.2	0.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	-0.4	-0.1	-0.2	-0.2	-0.1	-0.3
Condit. Reinf. lever presses	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.4	0.0	-0.2	-0.1
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.2	0.2	-0.0	-0.0
Pavlov. Cond. lever latency	0.2	0.3	0.7	-0.6	0.3	0.7	0.9	0.3	0.6	0.4
Pavlov. Cond. magazine entry latency	0.5	0.6	0.9	0.8	-0.5	-0.8	-0.9	-0.8	-1.0	-0.7
Pavlov. Cond. change in total contacts	0.0	0.1	0.2	-0.2	0.2	0.2	-0.4	0.2	-0.2	0.1
Pavlov. Cond. index score	0.3	0.4	0.6	0.6	-0.3	-0.7	-0.8	-0.5	-0.7	-0.5
Pavlov. Cond. latency score	0.1	0.2	0.3	0.4	-0.2	-0.4	-0.5	-0.4	-0.5	-0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.1	0.0	-0.3	-0.3	0.1	0.1	-0.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	-0.5	0.6	0.5	0.6	0.7	0.7	0.7
Pavlov. Cond. intertrial magazine entries	2.2	2.8	3.5	-1.7	1.6	1.6	1.9	1.6	1.6	1.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.4	-0.2	-0.5	-0.7	-0.4	-0.6	-0.4
Pavlov. Cond. response bias	0.4	0.6	0.8	0.7	-0.7	-0.8	-0.9	-0.7	-0.6	-0.8
Conditioned reinforcement - actives	0.5	0.5	1.1	1.0	-0.5	-1.0	0.2	-0.9	0.1	-0.6
Conditioned reinforcement - inactives	0.6	0.7	1.6	0.3	-1.3	-0.4	0.2	-1.1	-0.3	-1.2
Conditioned locomotion	0.7	0.9	2.2	0.7	-1.5	-0.6	0.1	-1.3	0.1	-1.1
Intermittent access intake day 1-15 change	1.4	1.4	1.8	-1.2	1.3	1.2	1.3	1.1	1.1	1.2
Intermittent access intake escalation	1.9	1.8	2.7	-1.3	1.6	1.1	1.4	1.3	1.2	1.5
Intermittent access intake escalation 2	4.0	4.0	4.7	-2.0	2.2	2.0	2.1	1.8	1.8	2.1
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	-0.1	-0.2	0.2	0.2	0.4	0.5	-0.1
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	-0.1	-0.2	0.0	0.5	-0.3	0.2	-0.1
Intermitt. access escalation Index	0.2	0.1	0.4	0.6	0.1	-0.6	-0.4	0.2	-0.2	0.1
Intermittent access day 1 total infusions	3.5	4.0	6.7	1.5	-2.6	-1.4	-1.6	-2.5	-1.6	-2.3
Intermittent access day 15 total infusions	0.4	0.4	0.8	0.3	-0.9	-0.3	-0.5	-0.9	-0.5	-0.9
Intermittent access terminal intake (last 3 days)	0.6	0.7	1.2	0.6	-1.1	-0.5	-0.4	-1.1	-0.6	-1.1
Intermittent access total infusions	1.6	1.8	3.2	1.1	-1.8	-0.9	-0.8	-1.8	-0.8	-1.7
Intermittent access day 1 locomotion	2.6	2.6	5.5	1.2	-2.3	-0.9	-1.3	-1.8	-1.2	-2.0
Intermittent access day 15 total locomotion	2.1	2.2	4.1	1.4	-2.0	-1.3	-0.9	-1.8	-0.7	-1.9
Intermittent access total locomotion	1.1	1.2	3.3	0.6	-1.8	-0.3	-0.4	-1.5	-0.4	-1.5
Intermittent access standard deviation	0.4	0.5	0.7	-0.5	0.6	0.6	0.7	0.7	0.9	0.7
Cocaine induced anxiety	0.2	0.3	0.5	0.7	-0.3	-0.7	-0.6	-0.3	-0.6	-0.3
Post-drug Anxiety	0.0	0.0	0.2	0.1	-0.0	-0.1	-0.2	-0.1	-0.4	0.0
Baseline Anxiety	0.0	0.1	0.2	0.3	0.1	-0.4	-0.2	0.1	-0.2	-0.1
Lifetime Intake	2.0	2.3	3.6	1.3	-1.8	-1.2	-1.1	-1.9	-1.2	-1.7
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.3	-0.2	0.5	0.5	-0.5	0.3	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.3	-0.1	0.4	0.5	-0.4	0.3	-0.2
Progressive ratio test 1 active lever presses	0.7	0.8	2.3	0.0	-1.5	0.1	-0.1	-1.2	-0.2	-1.3
Progressive ratio test 1 breakpoint	0.8	0.8	2.4	0.1	-1.6	0.1	-0.2	-1.1	-0.3	-1.3
Progressive ratio test 1 inactive lever presses	0.8	0.8	2.2	0.5	-1.5	-0.5	-0.1	-1.2	-0.1	-1.4
Progressive ratio test 2 active lever presses	0.4	0.4	1.5	0.1	-0.9	-0.0	0.0	-1.2	-0.2	-0.9
Progressive ratio test 2 breakpoint	0.5	0.6	1.7	0.4	-1.0	-0.2	-0.1	-1.3	-0.3	-1.0
Progressive ratio test 2 inactive lever presses	0.3	0.4	1.1	0.3	-0.8	-0.3	-0.1	-1.0	-0.3	-0.8
Total sessions with >9 infusions	0.4	0.5	1.2	0.2	-1.1	-0.0	-0.5	-0.9	-0.6	-0.7
Short access day 1 total inactive lever presses	0.5	0.5	1.4	0.5	-1.2	-0.4	-0.0	-0.6	0.1	-1.2
Short access day 10 total inactive lever presses	0.2	0.2	0.4	-0.5	0.3	0.6	0.5	0.5	0.4	0.3
Short access day 1 total infusions	1.1	1.1	1.8	0.8	-1.3	-0.7	-1.0	-1.2	-1.1	-1.2
Short access day 10 total infusions	3.5	3.8	4.6	1.9	-2.0	-1.8	-1.9	-2.1	-1.9	-2.0
Short access total infusions	1.6	1.8	2.6	1.3	-1.3	-1.1	-1.2	-1.6	-1.4	-1.2
Short access day 1 locomotion	2.0	2.1	3.6	1.5	-1.9	-1.2	-1.0	-1.7	-0.9	-1.6
Short access day 10 total locomotion	2.1	2.3	4.0	1.4	-2.0	-1.1	-1.6	-1.2	-1.4	-1.7
Short access total locomotion	1.1	1.2	2.7	0.9	-1.7	-0.5	-0.9	-1.1	-0.8	-1.3
Compulsive drug intake	0.2	0.2	0.4	-0.3	0.6	0.2	0.4	0.4	0.4	0.6
One hour access (0.3 mA shock)	1.8	2.0	3.7	1.5	-1.6	-1.5	-0.8	-1.9	-1.0	-1.5
One hour access (shock baseline)	1.1	1.3	2.4	1.0	-1.5	-1.0	-0.4	-1.5	-0.5	-1.5
Number of responses in last shaping day	1.5	1.5	2.1	-1.3	0.9	1.4	1.1	1.4	1.5	1.1
Context. condit. distance diff. score	0.6	0.8	1.1	-0.8	0.9	0.5	1.0	1.0	1.0	0.8
Locomotion velocity, session 1	1.0	1.1	2.8	0.6	-0.8	-0.6	-1.4	-0.9	-1.7	-0.9
Locomotion distance, session 1	1.1	1.4	2.6	0.5	-1.2	-0.6	-1.5	-1.3	-1.6	-1.2
Locomotion velocity, session 2	0.6	0.7	1.0	0.6	-0.8	-0.7	-1.0	-0.8	-0.9	-0.8
Locomotion distance, session 2	0.5	0.7	2.0	0.2	-0.6	-0.4	-1.3	-0.6	-1.4	-0.5
Locomotion velocity, session 3	3.5	4.1	4.7	1.9	-2.0	-2.0	-1.9	-2.2	-2.1	-2.2
Locomotion distance, session 3	2.6	2.9	3.8	1.6	-1.8	-1.6	-1.9	-1.3	-1.7	-1.7
Stereotopy head waving bouts, day 3	1.6	1.9	3.3	1.6	-1.5	-1.8	-1.0	-1.3	-0.9	-1.5
Stereotopy head waving duration, day 3	0.5	0.6	1.0	0.8	-0.8	-1.0	-0.3	-0.9	-0.3	-0.8
Locomotion velocity, session 7	3.7	4.0	6.6	2.0	-1.8	-1.8	-2.6	-1.5	-2.4	-1.9
Locomotion distance, session 7	0.4	0.5	1.6	0.5	-0.2	-0.6	-1.3	0.1	-1.0	-0.2
Stereotopy head waving bouts, day 7	0.0	0.1	0.2	0.1	-0.2	-0.2	0.2	-0.4	-0.0	-0.2
Stereotopy head waving duration, day 7	0.7	0.8	1.4	0.8	-0.9	-0.9	-0.6	-1.2	-0.8	-1.0
Locomotion velocity, session 8	1.9	2.3	4.6	1.2	-1.2	-1.3	-2.1	-1.2	-2.1	-1.2
Locomotion distance, session 8	0.0	0.1	0.2	-0.2	0.1	-0.1	-0.4	0.2	-0.3	0.0
Degree of sensitization distance	1.6	1.6	2.8	-1.1	1.7	1.0	0.9	1.5	0.9	1.6
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.4	0.1	0.4	0.4	-0.0	0.2	0.1
Condit. Reinf. active minus inactive responses	0.9	1.0	1.6	-0.9	1.2	1.1	0.2	1.3	0.2	1.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	0.2	0.4	-0.1	0.2	-0.4	0.2
Condit. Reinf. active responses	0.3	0.3	0.6	-0.4	0.7	0.5	-0.5	0.8	-0.3	0.7
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.1	0.3	-0.0	-0.6	0.3	-0.4	0.3
Incentive salience index mean	0.1	0.1	0.2	-0.2	0.4	0.3	-0.4	0.5	-0.3	0.4
Condit. Reinf. lever presses	0.2	0.3	0.4	0.4	-0.5	-0.3	-0.6	-0.5	-0.6	-0.6
Time in familiar zone, hab. session 1	0.0	0.0	0.2	-0.0	-0.1	0.1	-0.3	0.4	-0.1	-0.1
Time in novel zone, hab. session 1	0.8	0.8	1.2	-1.1	1.0	1.0	0.6	1.0	0.5	1.0
Total zone transitions, hab. session 1	0.1	0.2	0.5	-0.7	0.1	0.7	0.1	0.5	0.2	0.2
Total locomotion distance, hab. session 1	0.1	0.2	0.3	-0.5	0.1	0.6	0.3	0.6	0.4	0.1
Locomotion velocity, hab. session 1	0.0	0.1	0.2	-0.2	-0.1	0.2	0.3	0.3	0.4	-0.0
Time in familiar zone, hab. session 2	2.1	2.2	3.2	1.6	-1.3	-1.8	-1.3	-1.4	-1.5	-1.4
Time in novel zone, hab. session 2	2.2	2.2	3.1	-1.5	1.4	1.7	1.1	1.7	1.4	1.5
Total zone transitions, hab. session 2	0.4	0.5	0.9	0.4	-0.6	-0.5	-0.9	-0.6	-0.9	-0.7
Total locomotion distance, hab. session 2	0.0	0.0	0.1	0.1	-0.2	-0.3	-0.2	0.2	-0.1	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.2	-0.3	-0.5	-0.3	-0.0	-0.3	-0.4
Novel to familiar place preference ratio	1.7	1.7	2.6	-1.6	1.3	1.6	1.1	1.2	0.9	1.4
Novelty place preference	1.8	1.9	2.8	-1.7	1.4	1.7	1.2	1.2	1.0	1.4
Time in novel zone, NPP test	1.8	1.9	2.9	-1.7	1.4	1.7	1.1	1.2	0.9	1.4
Total zone transitions, NPP test	0.4	0.6	1.2	0.2	-1.1	-0.4	-0.9	-0.6	-0.7	-1.0
Total locomotion distance, NPP test	0.2	0.3	0.7	0.1	-0.9	-0.2	-0.7	-0.2	-0.4	-0.7
Locomotion velocity, NPP test	0.6	0.9	1.9	0.6	-1.4	-0.7	-0.7	-0.9	-0.6	-1.3
Pavlov. Cond. lever latency	1.8	2.2	3.6	-1.9	1.3	1.7	1.5	1.2	1.3	1.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.6	0.7	-0.4	-0.4	-0.1	-0.1	0.2	-0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.3	-0.1	0.0	-0.3	0.2	-0.0	-0.1
Pavlov. Cond. index score	0.4	0.5	1.1	1.1	-0.6	-0.8	-0.6	-0.3	-0.4	-0.7
Pavlov. Cond. latency score	0.3	0.4	1.0	1.0	-0.5	-0.7	-0.6	-0.3	-0.4	-0.6
Pavlov. Cond. lever contacts	0.8	0.9	1.9	1.4	-0.8	-1.2	-0.9	-0.6	-0.7	-0.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	-0.8	0.4	0.6	0.3	0.2	0.2	0.5
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.5	0.7	-0.5	-0.8	-1.2	-1.0	-1.2	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.5	1.2	-0.8	-0.9	-0.8	-0.5	-0.5	-0.9
Pavlov. Cond. response bias	0.7	0.9	1.9	1.4	-0.8	-1.1	-0.7	-0.7	-0.6	-0.9
Bone: apparent density	5.4	9.0	12.0	3.3	-2.3	-3.5	-3.0	-3.0	-3.2	-2.5
Bone surface	2.3	4.0	5.7	2.4	-1.4	-2.3	-1.9	-2.1	-2.1	-1.6
Bone volume	2.3	3.9	6.0	2.4	-1.3	-2.4	-1.9	-1.9	-2.1	-1.5
Bone: connectivity density	6.8	10.6	12.8	3.3	-2.7	-3.5	-3.4	-3.4	-3.6	-2.8
Bone: cortical apparent density	0.4	0.5	0.9	0.4	-1.0	-0.2	-0.4	-0.9	-0.7	-0.9
Bone: cortical area	0.1	0.1	0.4	0.7	-0.2	-0.2	-0.2	-0.3	-0.1	-0.2
Bone: cortical porosity	0.2	0.3	0.5	0.5	0.1	-0.4	-0.6	-0.7	-0.7	-0.0
Bone: cortical porosity	0.2	0.2	0.5	0.4	0.2	-0.2	-0.6	-0.6	-0.7	0.1
Bone: cortical thickness	0.2	0.3	0.5	-0.2	0.6	0.7	0.6	0.3	0.4	0.7
Bone: cortical thickness	0.3	0.3	0.6	0.6	-0.3	-0.3	-0.8	-0.7	-0.8	-0.3
Bone: cortical tissue density	0.3	0.4	0.8	0.3	-0.9	-0.2	-0.3	-0.8	-0.6	-0.8
Bone: elastic displacement	0.1	0.2	0.5	0.7	0.1	-0.5	-0.4	-0.3	-0.3	0.1
Bone: elastic work	0.7	0.9	1.6	1.3	-0.4	-1.1	-1.2	-0.8	-1.1	-0.5
Bone: endosteal estimation	0.2	0.4	0.6	0.8	-0.5	-0.7	-0.7	-0.5	-0.6	-0.5
Bone: endosteal perimeter	0.1	0.2	0.3	0.5	-0.5	-0.3	0.3	-0.1	0.5	-0.4
Bone: final force	0.7	1.1	2.2	1.0	-0.6	-1.0	-1.0	-1.2	-1.5	-0.7
Bone: final moment	0.6	1.0	2.1	0.9	-0.5	-1.0	-1.0	-1.1	-1.4	-0.6
Bone: marrow area	0.2	0.4	0.5	0.7	-0.5	-0.7	-0.7	-0.4	-0.5	-0.5
Bone: maximum diameter	0.5	1.0	1.8	1.1	-1.4	-0.7	-0.6	-1.2	-0.6	-1.2
Bone: maximum force	0.1	0.1	0.4	0.1	0.3	-0.0	-0.3	-0.0	-0.6	0.2
Bone: maximum moment	0.1	0.1	0.3	-0.0	0.3	0.0	-0.3	0.0	-0.6	0.3
Bone: minimum diameter	0.1	0.1	0.6	0.8	0.1	-0.4	-0.4	0.0	-0.1	-0.0
Bone: periosteal estimation	0.2	0.4	0.9	0.9	-0.6	-0.6	-0.5	-0.6	-0.4	-0.5
Bone: periosteal perimeter	0.1	0.2	0.7	0.1	0.1	0.3	0.6	0.3	0.8	0.2
Bone: post-yield work	0.0	0.1	0.1	-0.2	-0.3	0.1	-0.3	0.2	-0.1	-0.2
Bone: stiffness	0.3	0.5	0.9	-0.7	0.9	0.7	0.4	0.8	0.2	0.9
Bone: tissue strength	0.2	0.2	0.5	-0.7	0.5	0.6	0.0	0.4	-0.2	0.6
Bone: trabecular number	5.7	8.9	11.1	3.1	-2.5	-3.3	-3.0	-3.1	-3.2	-2.6
Bone: trabecular spacing	2.9	3.7	4.7	-2.0	1.8	2.2	1.9	1.9	1.9	1.8
Bone: trabecular thickness	1.4	1.7	2.9	1.6	-0.8	-1.7	-1.4	-1.1	-1.4	-1.0
Bone: trabecular tissue density	0.1	0.1	0.2	0.2	-0.4	-0.0	0.2	-0.3	0.0	-0.4
Breakpoint value in progressive ratio session	0.6	0.6	1.5	0.3	-1.1	-0.1	-0.5	-0.9	-0.6	-1.2
Distance traveled before self-admin	1.4	1.5	3.0	-1.1	0.8	1.1	1.3	1.3	1.7	0.7
Distance traveled after self-admin	1.4	1.5	2.7	-1.4	0.8	1.3	1.4	0.9	1.6	1.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.2	0.0	0.1	-0.6	0.0	-0.6	0.0
Delta time in open arm before/after self-admin	0.7	0.7	1.6	0.6	-1.3	-0.7	-0.6	-0.9	-0.6	-1.0
Diff in mean of infusions in LGA sessions	0.2	0.2	0.7	-0.0	-0.4	0.1	0.2	-0.9	-0.4	-0.6
Extinction: sum of active levers before priming	0.2	0.2	0.4	-0.3	0.6	0.4	-0.0	0.6	0.3	0.2
Active lever presses in extinction session 6	0.4	0.4	1.3	0.3	0.9	-0.2	1.2	0.2	0.8	0.3
Delta distance traveled before/after self-admin	0.2	0.3	0.8	-0.7	0.2	0.5	0.9	-0.1	0.5	0.4
Delta ambulatory time before/after self-admin	0.2	0.2	0.7	0.3	-0.4	-0.4	0.1	-0.9	-0.2	-0.3
Time in closed arm before self-admin	1.6	1.8	3.9	-1.0	1.0	1.1	2.0	0.9	2.0	1.1
Time in closed arm after self-admin	2.8	2.9	5.5	-1.5	1.1	1.6	2.3	1.1	2.4	1.4
Time in open arm before self-admin	0.3	0.3	0.5	-0.7	0.6	0.5	-0.6	0.4	-0.6	0.5
Time in open arm after self-admin	1.3	1.4	2.5	0.6	-1.1	-0.9	-1.6	-1.0	-1.6	-1.3
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.8	0.8	-0.3	-0.9	-0.7	-0.6	-0.9	-0.6
Time to tail flick, vehicle, before self-admin	5.5	5.5	7.3	-2.1	2.7	2.3	2.0	2.6	2.1	2.5
Time to tail flick, vehicle, after self-admin	1.4	1.5	3.5	-0.9	0.5	0.9	1.6	1.5	1.9	0.1
Time to tail flick, test, before self-admin	0.8	0.8	1.6	-1.1	0.3	1.3	0.9	0.6	1.0	0.4
Time to tail flick, test, after self-admin	2.1	2.1	4.0	-1.2	1.0	0.9	1.7	1.9	2.0	0.9
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.7	0.8	-1.0	-1.0	-0.6	-0.5	-0.4	-1.3
Delta time to tail flick, test, before/after SA	0.6	0.6	1.7	1.1	-0.4	-1.3	-0.5	0.1	-0.2	-0.8
Ambulatory time before self-admin	1.7	1.8	3.6	-1.2	0.8	1.4	1.5	1.3	1.9	0.9
Ambulatory time after self-admin	1.1	1.2	3.1	-0.9	0.7	0.7	1.6	0.7	1.8	0.7
Total heroin consumption	2.2	2.7	4.0	1.1	-2.0	-1.1	-1.5	-1.9	-1.8	-1.8
Area under the delay curve	1.8	1.9	2.3	1.5	-1.5	-1.5	-1.2	-1.3	-1.0	-1.4
Delay disc. indifference point, 0s delay	1.0	1.0	1.4	-1.1	1.0	1.2	1.0	0.9	1.0	0.8
Delay disc. indifference point, 16s delay	2.0	2.0	2.4	1.6	-1.3	-1.5	-1.4	-1.5	-1.3	-1.3
Delay disc. indifference point, 2s delay	0.9	1.0	1.4	1.0	-1.0	-1.1	-0.7	-1.2	-0.7	-1.1
Delay disc. indifference point, 24s delay	5.2	5.0	6.6	2.5	-2.2	-2.6	-2.2	-2.1	-1.9	-2.1
Delay disc. indifference point, 4s delay	0.6	0.7	1.2	0.9	-0.7	-1.1	-0.8	-0.8	-0.9	-0.6
Delay disc. indifference point, 8s delay	2.2	2.3	2.8	1.6	-1.7	-1.5	-1.6	-1.5	-1.2	-1.5
Delay discount exponential model param	2.5	2.6	3.0	-1.7	1.7	1.7	1.5	1.6	1.3	1.6
Delay discount hyperbolic model param	2.3	2.4	2.9	-1.7	1.7	1.7	1.4	1.5	1.3	1.6
Fecal boli incidents, locomotor time 1	0.0	0.0	0.2	-0.3	0.2	0.4	-0.1	-0.1	0.1	-0.0
Change in fecal boli incidents, locomotor task	5.2	4.9	8.2	-1.7	2.3	1.5	1.8	2.9	2.3	2.7
Time >=10cm from walls, locomotor time 1	3.1	3.2	5.3	-2.0	2.3	1.9	0.6	1.9	0.7	2.1
Bouts of movement, locomotor time 1	0.8	0.9	1.8	0.8	-0.8	-0.8	-1.4	-0.9	-1.1	-0.7
Total resting periods, locomotor time 1	0.8	0.9	2.2	0.8	-0.6	-0.9	-1.5	-0.8	-1.2	-0.6
Rest time, locomotor task time 1	0.2	0.2	0.7	-0.1	0.4	-0.1	-0.8	0.2	-0.7	0.3
Distance moved, locomotor task time 1	0.1	0.1	0.4	-0.4	0.0	0.6	0.6	-0.1	0.4	0.2
Vertical activity count, locomotor time 1	0.2	0.2	0.4	-0.3	0.3	0.3	0.6	0.2	0.5	0.5
Time >=10cm from walls, locomotor time 2	1.3	1.3	1.8	-1.2	1.2	1.2	0.8	1.3	0.9	1.4
Bouts of movement, locomotor time 2	2.0	2.1	3.8	-1.4	2.0	1.2	0.8	1.8	1.0	1.8
Total resting periods, locomotor time 2	1.7	1.8	3.2	-1.2	1.8	1.1	0.7	1.7	0.9	1.6
Rest time, locomotor task time 2	0.7	0.8	1.2	0.8	-1.0	-0.8	-1.1	-0.5	-0.9	-0.9
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.3	0.4	0.4	0.5	0.1	0.2	0.4
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.0	0.4	0.1	0.5	0.1	0.2	0.5
Weight adjusted by age	0.5	0.5	1.8	0.5	-0.8	-0.7	-0.4	-1.3	-0.5	-0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.5	-0.2	-0.3	-0.1	0.7	0.0	0.5	-0.3
Locomotion in novel chamber	0.2	0.3	0.7	-0.8	0.4	0.9	0.5	0.4	0.4	0.0
Locomotion in novel chamber post-restriction	2.8	3.3	6.1	-2.4	1.3	2.5	1.7	1.5	1.5	1.5
Progressive ratio	0.3	0.4	0.8	0.8	-0.9	-0.7	-0.0	-0.2	0.1	-0.7
Food seeking constrained by brief footshock	1.7	2.0	3.8	1.6	-1.5	-1.6	-1.0	-2.0	-1.1	-1.1
Seeking ratio, punishment vs. effort	0.1	0.1	0.4	-0.2	0.3	0.1	-0.2	-0.7	-0.3	0.4
Run reversals in cocaine runway, females	0.1	0.1	0.5	0.4	-0.0	-0.0	0.4	-0.0	0.7	0.3
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.2	-0.1	-0.5	0.2	-0.1	0.2	-0.2
Latency to leave start box in cocaine runway	0.9	1.0	1.6	1.3	-0.7	-1.2	-0.9	-1.0	-1.0	-0.8
Latency to leave start box in cocaine runway, F	1.7	1.9	2.6	1.6	-1.2	-1.6	-1.4	-1.3	-1.4	-1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.2	0.4	0.1	0.3	0.1	0.3	0.2
Cd content in liver	0.3	0.3	0.6	-0.5	0.8	0.3	0.4	0.6	0.4	0.7
Co content in liver	1.7	2.0	2.9	1.3	-1.6	-1.1	-1.4	-1.7	-1.1	-1.5
Cu content in liver	0.2	0.2	0.4	0.6	-0.2	-0.5	-0.7	-0.3	-0.4	-0.2
Fe content in liver	0.0	0.0	0.1	0.0	0.4	-0.3	0.2	0.1	0.0	0.1
K content in liver	0.1	0.1	0.2	0.0	-0.4	-0.1	0.2	-0.1	0.3	-0.2
Mg content in liver	1.7	1.7	3.0	1.2	-1.7	-1.3	-1.1	-1.2	-1.1	-1.5
Mn content in liver	1.7	2.0	2.9	1.5	-1.6	-1.5	-1.2	-1.3	-0.9	-1.7
Na content in liver	0.6	0.7	1.1	0.9	-0.9	-0.9	0.5	-1.0	0.2	-0.9
Rb content in liver	1.2	1.4	1.8	1.2	-1.4	-1.1	-1.1	-1.2	-1.1	-1.3
Se content in liver	0.0	0.1	0.2	-0.3	0.1	-0.0	0.4	0.2	0.3	0.1
Sr content in liver	1.8	1.6	2.7	-0.8	1.4	0.8	1.4	1.5	1.6	1.2
Zn content in liver	0.1	0.1	0.5	-0.2	-0.0	0.1	0.5	0.4	0.7	0.2