Hub : Genes

Aff4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000006965 0.1 0.06 3.9e-04 0 0.04 0.02 0.01 2.1e-01 2.8e-03 2.1e-02 6.9e-02
2 Brain mRNA stability ENSRNOG00000006965 0.06 0.04 1.4e-03 0 0.01 0.01 0 1.4e-01 4.9e-02 4.4e-02 1.7e-01
3 Liver mRNA stability ENSRNOG00000006965 0.04 0.03 5.0e-04 0 0.02 0 0 2.6e-01 5.5e-03 2.7e-01 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.00.00.0-0.00.10.1
BMI without tail0.00.10.20.1-0.50.1
Body weight0.41.83.50.81.91.1
Epididymis fat weight1.43.26.31.42.51.2
Glucose0.91.41.9-1.40.9-1.3
Heart weight1.01.53.9-0.62.0-0.4
Left kidney weight5.114.532.12.25.72.6
Right kidney weight4.111.717.32.94.23.1
Tail length0.51.52.21.01.51.1
Length with tail1.03.67.41.12.71.4
Length without tail1.53.47.51.02.71.2
Liver weight, left0.81.31.5-1.21.2-1.0
Liver weight, right0.71.11.3-1.11.1-0.9
Parametrial fat weight2.65.16.72.61.42.5
Retroperitoneal fat weight1.13.73.92.02.01.8
Intraocular pressure0.10.10.2-0.4-0.1-0.5
Extensor digitorum longus weight0.20.90.90.9-0.91.0
Soleus weight1.02.94.02.01.02.0
Tibialis anterior weight0.30.92.8-0.0-1.7-0.1
Tibia length0.10.41.00.11.00.3
Number of licking bursts0.10.10.20.20.40.3
Food consumed during 24 hour testing period4.95.97.12.22.72.3
Times rat made contact with spout0.91.01.11.01.01.1
Mean time between licks in bursts2.94.05.42.31.32.2
Mean num. licks in bursts0.00.00.0-0.1-0.2-0.2
Std. dev. time between licks in bursts2.83.44.92.20.52.2
Water consumed over 24 hours1.51.74.60.52.10.6
Indifference point 0 sec3.86.17.9-2.8-1.7-2.8
Indifference point AUC0.20.30.40.6-0.10.6
Indifference point function ln k0.10.10.20.10.50.0
Indifference point function log k0.10.10.20.10.50.0
Delay discounting total patch changes 0 sec3.86.17.5-2.7-1.9-2.7
Delay discounting total patch changes 12 sec2.63.56.5-1.4-2.5-1.4
Delay discounting total patch changes 18 sec1.31.72.4-1.5-1.0-1.4
Delay discounting total patch changes 24 sec2.43.03.2-1.8-1.7-1.7
Delay discounting total patch changes 6 sec2.64.04.7-2.0-2.2-1.9
Delay discounting time to switch 0 sec0.20.30.9-0.1-1.0-0.1
Delay discounting water rate 0 sec0.20.30.30.60.50.5
Delay discounting water rate 12 sec0.10.20.30.60.40.4
Delay discounting water rate 18 sec1.41.92.9-1.1-1.7-1.3
Delay discounting water rate 24 sec0.60.82.2-0.1-1.5-0.5
Delay discounting water rate 6 sec0.91.31.41.11.21.1
Locomotor activity0.71.02.2-0.7-1.5-0.7
Locomotor testing distance2.23.66.0-1.5-2.5-1.6
Locomotor testing rearing1.42.24.5-1.0-2.1-1.1
Light reinforcement 10.40.72.0-0.3-1.4-0.3
Light reinforcement 20.00.00.00.00.1-0.1
Reaction time number correct0.00.10.10.4-0.00.3
Reaction time mean minus median1.41.82.71.60.11.7
Reaction time mean minus median AUC0.20.30.50.60.20.7
Reaction time num false alarms0.30.50.5-0.7-0.6-0.7
Reaction time num false alarms AUC0.60.91.1-1.1-0.6-1.1
Reaction time trials correct on left0.00.10.10.4-0.00.3
Reaction time trials on left0.10.10.20.4-0.00.4
Reaction time mean2.53.45.02.20.72.2
Reaction time mean AUC2.02.63.71.90.71.9
Median of all reaction times2.73.75.32.30.92.2
Reaction time omissions1.31.82.71.60.31.6
Reaction time false alarm rate0.50.71.0-1.0-0.3-1.0
Reaction time premature initiation rate0.60.81.0-1.0-0.6-0.9
Reaction time premature initiations0.20.30.4-0.6-0.6-0.5
Std. dev. reaction times0.81.11.71.3-0.31.3
Reaction time trials completed0.10.10.20.4-0.00.4
Reaction time trials AUC0.10.10.10.4-0.30.3
Social response proportion0.00.00.1-0.10.2-0.3
Social responses0.20.30.4-0.6-0.2-0.6
Social time0.50.71.3-0.7-1.1-0.6
Conditioned locomotion0.20.20.60.10.80.2
Cocaine response after cond. corrected0.10.10.1-0.2-0.4-0.4
Cocaine response after cond. not corrected0.30.40.7-0.3-0.9-0.5
Cocaine response before conditioning0.50.60.9-0.7-0.9-0.5
Saline control response0.50.60.9-1.0-0.6-0.8
Condit. Reinf. active minus inactive responses0.40.51.40.1-1.2-0.0
Condit. Reinf. active-inactive response ratio0.10.10.10.4-0.30.2
Condit. Reinf. active responses0.71.02.2-0.7-1.5-0.6
Condit. Reinf. inactive responses1.62.02.4-1.5-1.5-1.2
Condit. Reinf. lever presses0.30.41.2-0.0-1.1-0.1
Condit. Reinf. lever reinforcers received0.71.02.4-0.6-1.5-0.6
Pavlov. Cond. lever latency0.40.60.7-0.8-0.6-0.8
Pavlov. Cond. magazine entry latency1.51.82.41.50.81.5
Pavlov. Cond. change in total contacts0.10.10.20.5-0.30.4
Pavlov. Cond. index score0.91.21.61.30.51.3
Pavlov. Cond. latency score1.31.72.31.50.71.5
Pavlov. Cond. lever contacts0.71.01.31.10.71.1
Pavlov. Cond. magazine entry number0.40.50.8-0.9-0.1-0.8
Pavlov. Cond. intertrial magazine entries2.02.64.2-1.3-2.0-1.3
Pavlov. Cond. lever-magazine prob. diff.1.01.21.81.30.41.3
Pavlov. Cond. response bias1.31.72.21.50.91.5
Conditioned reinforcement - actives0.20.20.3-0.50.2-0.4
Conditioned reinforcement - inactives0.60.70.8-0.9-0.7-0.9
Conditioned locomotion1.11.42.1-1.0-1.5-1.0
Intermittent access intake day 1-15 change0.20.20.4-0.3-0.6-0.3
Intermittent access intake escalation0.10.10.2-0.2-0.4-0.3
Intermittent access intake escalation 20.10.10.2-0.3-0.5-0.3
Intermitt. access day 1 inactive lever presses0.10.10.2-0.10.5-0.1
Intermitt. access day 15 inactive lever presses0.20.20.3-0.60.2-0.6
Intermitt. access escalation Index1.00.91.31.10.41.1
Intermittent access day 1 total infusions0.00.00.1-0.00.30.0
Intermittent access day 15 total infusions0.10.10.1-0.4-0.2-0.4
Intermittent access terminal intake (last 3 days)0.10.20.4-0.2-0.6-0.2
Intermittent access total infusions0.00.00.1-0.2-0.3-0.2
Intermittent access day 1 locomotion0.20.20.6-0.0-0.8-0.0
Intermittent access day 15 total locomotion2.02.15.5-0.7-2.3-0.7
Intermittent access total locomotion1.61.84.9-0.5-2.2-0.5
Intermittent access standard deviation0.60.70.8-0.80.9-0.8
Cocaine induced anxiety0.20.20.4-0.6-0.1-0.6
Post-drug Anxiety2.62.93.7-1.9-1.3-1.8
Baseline Anxiety0.60.61.90.0-1.4-0.1
Lifetime Intake0.00.00.00.2-0.00.2
Incentive Sensitization - Responses0.20.20.3-0.6-0.3-0.4
Incentive Sensitization - Breakpoint0.30.30.5-0.7-0.2-0.5
Progressive ratio test 1 active lever presses0.40.41.2-0.1-1.1-0.1
Progressive ratio test 1 breakpoint0.30.41.0-0.2-1.0-0.2
Progressive ratio test 1 inactive lever presses0.00.00.10.1-0.3-0.0
Progressive ratio test 2 active lever presses0.10.10.2-0.1-0.4-0.0
Progressive ratio test 2 breakpoint0.20.20.2-0.4-0.5-0.4
Progressive ratio test 2 inactive lever presses0.30.30.4-0.70.3-0.6
Total sessions with >9 infusions0.91.01.61.30.31.2
Short access day 1 total inactive lever presses1.81.93.9-1.0-2.0-1.0
Short access day 10 total inactive lever presses0.40.40.6-0.80.4-0.7
Short access day 1 total infusions0.40.50.60.8-0.50.7
Short access day 10 total infusions0.20.20.40.30.70.4
Short access total infusions0.30.30.40.60.50.6
Short access day 1 locomotion0.10.10.2-0.0-0.4-0.1
Short access day 10 total locomotion0.10.10.2-0.20.5-0.2
Short access total locomotion0.10.10.1-0.30.3-0.2
Compulsive drug intake0.00.00.00.0-0.10.1
One hour access (0.3 mA shock)0.10.10.2-0.2-0.4-0.1
One hour access (shock baseline)0.40.40.5-0.6-0.7-0.6
Number of responses in last shaping day0.50.51.00.6-1.00.4
Context. condit. distance diff. score0.20.20.50.10.70.3
Locomotion velocity, session 10.10.10.10.3-0.30.3
Locomotion distance, session 11.01.31.81.20.91.3
Locomotion velocity, session 22.22.63.41.81.01.8
Locomotion distance, session 21.31.82.31.31.11.5
Locomotion velocity, session 32.83.36.91.02.61.4
Locomotion distance, session 32.32.55.70.82.41.1
Stereotopy head waving bouts, day 30.10.10.3-0.4-0.5-0.2
Stereotopy head waving duration, day 30.70.91.7-0.8-1.3-0.6
Locomotion velocity, session 70.10.10.30.30.20.5
Locomotion distance, session 70.00.00.10.0-0.30.2
Stereotopy head waving bouts, day 70.00.00.1-0.0-0.40.1
Stereotopy head waving duration, day 70.30.30.8-0.3-0.9-0.2
Locomotion velocity, session 83.94.65.81.82.42.2
Locomotion distance, session 81.62.44.41.02.11.3
Degree of sensitization distance2.42.46.1-0.8-2.5-0.7
Degree of sensitization stereotypy0.10.10.10.30.10.3
Condit. Reinf. active minus inactive responses1.11.22.11.4-0.11.2
Condit. Reinf. active-inactive response ratio1.01.11.81.40.41.1
Condit. Reinf. active responses0.50.61.00.7-1.00.4
Condit. Reinf. inactive responses2.02.32.7-1.4-1.7-1.5
Incentive salience index mean1.51.82.81.70.61.5
Condit. Reinf. lever presses1.31.82.01.41.21.4
Time in familiar zone, hab. session 14.13.94.1-1.9-2.0-2.0
Time in novel zone, hab. session 13.43.35.51.42.31.6
Total zone transitions, hab. session 12.02.94.52.0-0.22.1
Total locomotion distance, hab. session 10.10.10.20.1-0.20.4
Locomotion velocity, hab. session 10.10.10.30.20.10.5
Time in familiar zone, hab. session 20.30.30.5-0.7-0.3-0.5
Time in novel zone, hab. session 20.80.81.30.91.20.6
Total zone transitions, hab. session 22.22.84.31.80.92.1
Total locomotion distance, hab. session 20.20.30.60.50.20.8
Locomotion velocity, hab. session 20.40.50.90.60.51.0
Novel to familiar place preference ratio0.20.20.60.1-0.7-0.1
Novelty place preference0.10.10.30.0-0.6-0.2
Time in novel zone, NPP test0.10.10.2-0.0-0.5-0.2
Total zone transitions, NPP test1.21.72.61.6-0.21.6
Total locomotion distance, NPP test0.10.10.20.30.10.5
Locomotion velocity, NPP test0.20.30.40.5-0.30.7
Pavlov. Cond. lever latency0.30.40.50.7-0.70.6
Pavlov. Cond. magazine entry latency0.00.00.0-0.10.1-0.2
Pavlov. Cond. change in total contacts0.10.10.2-0.3-0.3-0.4
Pavlov. Cond. index score0.00.00.0-0.10.2-0.2
Pavlov. Cond. latency score0.10.20.2-0.40.4-0.4
Pavlov. Cond. lever contacts0.40.40.6-0.8-0.0-0.8
Pavlov. Cond. magazine entry number0.10.10.1-0.30.4-0.2
Pavlov. Cond. intertrial magazine entries2.32.85.91.2-2.41.0
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.2-0.1-0.3
Pavlov. Cond. response bias0.20.30.4-0.6-0.4-0.6
Bone: apparent density0.30.50.8-0.90.1-0.9
Bone surface0.10.10.2-0.50.2-0.4
Bone volume0.30.60.9-1.0-0.2-0.9
Bone: connectivity density0.10.10.1-0.3-0.1-0.3
Bone: cortical apparent density0.81.01.3-0.9-1.2-0.9
Bone: cortical area0.40.61.8-0.11.40.1
Bone: cortical porosity0.10.10.3-0.30.5-0.2
Bone: cortical porosity0.40.40.7-0.8-0.0-0.7
Bone: cortical thickness0.81.43.2-0.81.8-0.5
Bone: cortical thickness1.82.23.2-1.81.1-1.4
Bone: cortical tissue density0.81.11.6-0.9-1.3-0.9
Bone: elastic displacement0.10.10.3-0.10.5-0.2
Bone: elastic work1.21.63.7-0.81.9-0.8
Bone: endosteal estimation0.51.01.71.30.11.2
Bone: endosteal perimeter1.02.13.41.90.01.7
Bone: final force0.61.02.00.71.40.8
Bone: final moment0.60.92.20.51.50.6
Bone: marrow area0.51.21.91.40.11.3
Bone: maximum diameter1.01.72.11.41.11.4
Bone: maximum force0.30.61.7-0.11.30.1
Bone: maximum moment0.40.71.9-0.31.4-0.1
Bone: minimum diameter0.40.71.10.71.00.8
Bone: periosteal estimation0.30.70.70.80.90.8
Bone: periosteal perimeter0.30.50.60.80.50.7
Bone: post-yield work1.01.31.5-1.1-1.2-1.1
Bone: stiffness0.00.10.1-0.4-0.1-0.3
Bone: tissue strength0.70.71.90.11.40.4
Bone: trabecular number0.30.50.7-0.90.4-0.8
Bone: trabecular spacing0.20.30.50.7-0.20.6
Bone: trabecular thickness0.00.00.10.1-0.00.2
Bone: trabecular tissue density0.30.41.0-0.41.0-0.1
Breakpoint value in progressive ratio session0.70.81.0-1.0-0.7-1.0
Distance traveled before self-admin0.10.10.30.20.50.1
Distance traveled after self-admin0.40.51.20.5-1.10.2
Delta time in closed arm before/after self-admin0.60.60.80.7-0.90.6
Delta time in open arm before/after self-admin1.01.01.21.10.81.0
Diff in mean of infusions in LGA sessions1.71.93.0-1.60.3-1.7
Extinction: sum of active levers before priming0.10.10.2-0.20.5-0.2
Active lever presses in extinction session 61.71.63.9-0.6-2.0-0.8
Delta distance traveled before/after self-admin0.80.82.30.3-1.50.2
Delta ambulatory time before/after self-admin1.21.33.50.4-1.90.3
Time in closed arm before self-admin1.41.64.4-0.52.1-0.5
Time in closed arm after self-admin0.20.20.70.00.8-0.1
Time in open arm before self-admin1.01.12.8-0.5-1.7-0.4
Time in open arm after self-admin0.50.51.3-0.3-1.1-0.3
Sum of active levers in priming session hrs 5-60.00.00.00.1-0.20.2
Time to tail flick, vehicle, before self-admin2.42.43.5-1.51.9-1.2
Time to tail flick, vehicle, after self-admin0.91.01.2-0.91.1-0.9
Time to tail flick, test, before self-admin0.10.10.30.0-0.5-0.2
Time to tail flick, test, after self-admin0.10.10.4-0.2-0.6-0.2
Delta time to tail flick, vehicle, before/after SA0.80.81.60.7-1.30.5
Delta time to tail flick, test, before/after SA0.10.10.2-0.40.0-0.3
Ambulatory time before self-admin0.10.10.40.10.6-0.0
Ambulatory time after self-admin0.20.20.50.1-0.7-0.1
Total heroin consumption2.02.43.5-1.9-0.5-1.9
Area under the delay curve0.20.20.5-0.40.7-0.2
Delay disc. indifference point, 0s delay0.70.81.1-1.10.7-0.9
Delay disc. indifference point, 16s delay0.30.30.5-0.70.3-0.6
Delay disc. indifference point, 2s delay0.91.02.9-0.21.7-0.0
Delay disc. indifference point, 24s delay0.20.20.50.20.70.2
Delay disc. indifference point, 4s delay0.50.50.9-0.5-0.9-0.7
Delay disc. indifference point, 8s delay0.20.20.6-0.00.80.1
Delay discount exponential model param0.20.20.40.3-0.70.2
Delay discount hyperbolic model param0.30.30.50.5-0.70.4
Fecal boli incidents, locomotor time 10.30.30.4-0.7-0.4-0.5
Change in fecal boli incidents, locomotor task0.40.40.90.40.90.3
Time >=10cm from walls, locomotor time 12.52.52.8-1.5-1.7-1.6
Bouts of movement, locomotor time 11.51.62.6-1.60.1-1.5
Total resting periods, locomotor time 12.32.64.0-2.00.3-1.9
Rest time, locomotor task time 10.91.01.6-1.30.1-1.1
Distance moved, locomotor task time 10.00.00.1-0.1-0.1-0.3
Vertical activity count, locomotor time 10.20.20.6-0.0-0.7-0.2
Time >=10cm from walls, locomotor time 20.20.30.7-0.0-0.9-0.2
Bouts of movement, locomotor time 20.40.40.6-0.7-0.4-0.8
Total resting periods, locomotor time 20.50.60.8-0.9-0.2-0.9
Rest time, locomotor task time 21.51.73.0-1.7-0.3-1.4
Distance moved, locomotor task time 20.20.20.40.7-0.20.4
Vertical activity count, locomotor time 20.30.30.50.5-0.70.4
Weight adjusted by age0.20.20.7-0.20.80.0
Seeking ratio, delayed vs. immediate footshock0.91.01.8-1.40.2-1.1
Locomotion in novel chamber0.20.30.4-0.5-0.4-0.6
Locomotion in novel chamber post-restriction0.00.00.00.10.20.2
Progressive ratio0.20.20.5-0.1-0.7-0.2
Food seeking constrained by brief footshock0.10.10.1-0.3-0.2-0.3
Seeking ratio, punishment vs. effort0.20.30.4-0.50.6-0.4
Run reversals in cocaine runway, females0.00.00.00.0-0.2-0.0
Run reversals in cocaine runway, males0.30.30.9-0.0-0.9-0.3
Latency to leave start box in cocaine runway0.70.81.11.00.80.9
Latency to leave start box in cocaine runway, F0.70.72.00.41.40.3
Latency to leave start box in cocaine runway, M1.61.62.41.5-0.71.4
Cd content in liver0.70.82.40.0-1.6-0.2
Co content in liver0.00.00.10.20.20.1
Cu content in liver0.70.81.01.0-0.90.7
Fe content in liver0.30.40.6-0.60.7-0.5
K content in liver7.37.38.52.92.32.9
Mg content in liver3.13.24.52.10.82.1
Mn content in liver0.10.10.30.4-0.10.5
Na content in liver0.70.81.20.71.10.8
Rb content in liver0.70.92.50.2-1.60.1
Se content in liver0.81.02.70.41.60.4
Sr content in liver0.00.00.00.1-0.1-0.0
Zn content in liver1.61.82.91.70.41.5