Hub : Genes

Castor1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000006740 0.1 0.04 8.0e-10 0.08 0.07 0.06 0.07 6.2e-09 2.9e-08 7.5e-07 1.2e-08
2 BLA gene expression ENSRNOG00000006740 0.15 0.11 1.0e-02 0.04 0.01 0.01 0.04 3.5e-03 1.5e-01 6.2e-02 2.8e-03
3 NAcc gene expression ENSRNOG00000006740 0.06 0.03 7.4e-05 0.06 0.05 0.06 0.06 1.6e-05 1.4e-04 5.8e-05 3.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.51.74.10.90.32.0
BMI without tail0.30.61.00.21.00.8
Body weight2.18.910.52.53.23.2
Epididymis fat weight0.20.51.30.51.10.3
Glucose9.714.828.05.30.24.1
Heart weight0.30.40.8-0.6-0.1-0.9
Left kidney weight0.51.31.5-1.20.9-1.2
Right kidney weight0.72.02.5-1.61.5-1.2
Tail length1.54.411.40.83.41.1
Length with tail1.86.714.71.73.81.6
Length without tail1.12.53.21.81.51.5
Liver weight, left2.64.28.0-2.8-0.6-2.1
Liver weight, right3.76.110.0-3.2-1.7-2.4
Parametrial fat weight0.91.73.21.8-0.31.4
Retroperitoneal fat weight0.00.20.40.3-0.60.1
Intraocular pressure0.70.92.40.5-1.6-0.2
Extensor digitorum longus weight2.610.611.63.03.43.4
Soleus weight1.13.27.61.22.80.8
Tibialis anterior weight1.55.17.22.71.92.1
Tibia length0.41.12.5-0.61.6-0.6
Number of licking bursts1.51.72.91.41.70.5
Food consumed during 24 hour testing period0.30.40.90.6-0.9-0.1
Times rat made contact with spout1.51.74.60.6-2.2-0.5
Mean time between licks in bursts1.01.33.5-0.2-1.9-0.7
Mean num. licks in bursts3.03.69.0-1.0-3.0-0.9
Std. dev. time between licks in bursts1.11.32.0-1.1-1.4-1.0
Water consumed over 24 hours1.41.63.30.3-1.8-1.2
Indifference point 0 sec0.10.20.30.60.5-0.0
Indifference point AUC0.91.12.9-0.5-1.7-0.1
Indifference point function ln k0.60.82.1-0.51.4-0.1
Indifference point function log k0.60.82.1-0.51.4-0.1
Delay discounting total patch changes 0 sec0.10.20.50.70.40.1
Delay discounting total patch changes 12 sec0.00.10.10.30.10.3
Delay discounting total patch changes 18 sec0.60.81.51.2-0.60.7
Delay discounting total patch changes 24 sec2.53.15.5-1.6-2.3-1.2
Delay discounting total patch changes 6 sec0.10.10.20.5-0.40.2
Delay discounting time to switch 0 sec0.10.20.50.30.3-0.7
Delay discounting water rate 0 sec0.20.40.70.5-0.30.8
Delay discounting water rate 12 sec0.10.10.3-0.60.0-0.1
Delay discounting water rate 18 sec1.31.73.2-1.80.5-1.3
Delay discounting water rate 24 sec0.30.40.6-0.4-0.8-0.7
Delay discounting water rate 6 sec0.10.10.2-0.40.3-0.3
Locomotor activity0.30.51.31.20.30.1
Locomotor testing distance0.61.12.70.41.60.6
Locomotor testing rearing1.52.32.81.51.31.7
Light reinforcement 10.40.71.3-0.11.20.9
Light reinforcement 20.20.30.7-0.30.8-0.3
Reaction time number correct0.40.51.0-0.3-0.7-1.0
Reaction time mean minus median0.00.10.20.40.00.1
Reaction time mean minus median AUC0.40.50.70.50.90.7
Reaction time num false alarms0.81.11.40.81.01.2
Reaction time num false alarms AUC0.81.12.00.71.40.9
Reaction time trials correct on left0.40.51.0-0.3-0.7-1.0
Reaction time trials on left0.40.61.1-0.3-0.7-1.0
Reaction time mean0.00.00.0-0.1-0.1-0.1
Reaction time mean AUC0.00.00.1-0.30.0-0.2
Median of all reaction times0.00.10.1-0.3-0.2-0.2
Reaction time omissions0.10.10.4-0.6-0.1-0.1
Reaction time false alarm rate1.41.93.40.81.91.3
Reaction time premature initiation rate3.14.18.0-2.8-1.4-1.6
Reaction time premature initiations2.63.75.8-2.4-1.6-1.7
Std. dev. reaction times0.10.10.20.4-0.20.0
Reaction time trials completed0.40.61.1-0.3-0.7-1.0
Reaction time trials AUC0.30.40.9-0.2-0.6-1.0
Social response proportion0.50.61.00.7-1.0-0.4
Social responses0.30.40.91.0-0.6-0.1
Social time0.50.71.9-0.1-0.5-1.4
Conditioned locomotion0.20.20.5-0.7-0.0-0.2
Cocaine response after cond. corrected1.21.41.70.81.31.3
Cocaine response after cond. not corrected2.83.25.11.12.21.8
Cocaine response before conditioning0.20.20.4-0.20.60.4
Saline control response1.62.14.3-1.3-2.1-0.6
Condit. Reinf. active minus inactive responses0.81.01.3-1.2-1.1-0.7
Condit. Reinf. active-inactive response ratio0.20.20.3-0.1-0.50.5
Condit. Reinf. active responses2.33.14.5-1.9-2.1-1.1
Condit. Reinf. inactive responses2.83.53.9-2.0-2.0-1.7
Condit. Reinf. lever presses0.70.91.3-1.1-1.2-0.4
Condit. Reinf. lever reinforcers received2.02.84.1-1.9-2.0-0.8
Pavlov. Cond. lever latency2.73.77.11.52.71.3
Pavlov. Cond. magazine entry latency0.00.00.00.20.10.1
Pavlov. Cond. change in total contacts1.21.73.4-0.9-1.8-0.9
Pavlov. Cond. index score1.21.52.7-1.0-1.7-0.9
Pavlov. Cond. latency score1.11.42.3-1.1-1.5-0.9
Pavlov. Cond. lever contacts3.24.48.4-1.6-2.9-1.5
Pavlov. Cond. magazine entry number0.10.10.1-0.30.30.2
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.6-0.00.1
Pavlov. Cond. lever-magazine prob. diff.1.11.52.4-1.0-1.5-1.0
Pavlov. Cond. response bias1.62.24.6-0.8-2.2-1.1
Conditioned reinforcement - actives1.41.32.01.20.71.4
Conditioned reinforcement - inactives2.63.04.51.71.32.1
Conditioned locomotion0.50.50.70.70.80.7
Intermittent access intake day 1-15 change0.80.81.41.00.01.2
Intermittent access intake escalation0.50.40.70.80.00.9
Intermittent access intake escalation 20.10.10.20.3-0.4-0.3
Intermitt. access day 1 inactive lever presses0.50.51.1-1.0-0.60.3
Intermitt. access day 15 inactive lever presses0.60.61.10.7-0.61.0
Intermitt. access escalation Index0.30.30.7-0.4-0.8-0.2
Intermittent access day 1 total infusions0.50.51.11.10.50.4
Intermittent access day 15 total infusions1.41.62.91.70.61.2
Intermittent access terminal intake (last 3 days)0.50.51.21.10.20.6
Intermittent access total infusions0.70.81.31.20.60.7
Intermittent access day 1 locomotion1.21.21.7-0.7-1.3-1.3
Intermittent access day 15 total locomotion2.22.33.11.81.11.7
Intermittent access total locomotion0.70.81.31.10.31.0
Intermittent access standard deviation0.70.81.1-0.8-1.1-0.7
Cocaine induced anxiety0.60.71.21.1-0.20.9
Post-drug Anxiety0.50.50.91.00.20.8
Baseline Anxiety0.60.71.10.91.10.4
Lifetime Intake0.60.71.01.00.80.7
Incentive Sensitization - Responses0.70.72.01.40.30.4
Incentive Sensitization - Breakpoint0.80.82.11.40.30.4
Progressive ratio test 1 active lever presses1.61.72.61.30.81.6
Progressive ratio test 1 breakpoint1.31.32.21.00.81.5
Progressive ratio test 1 inactive lever presses3.33.55.31.71.52.3
Progressive ratio test 2 active lever presses1.11.12.21.50.60.9
Progressive ratio test 2 breakpoint0.91.02.11.50.30.8
Progressive ratio test 2 inactive lever presses2.63.05.42.30.61.8
Total sessions with >9 infusions0.10.10.2-0.50.00.0
Short access day 1 total inactive lever presses1.31.41.61.11.31.2
Short access day 10 total inactive lever presses0.70.71.8-1.4-0.5-0.2
Short access day 1 total infusions0.20.30.6-0.30.80.3
Short access day 10 total infusions0.10.10.2-0.2-0.2-0.5
Short access total infusions0.10.10.3-0.20.5-0.1
Short access day 1 locomotion1.31.32.4-1.6-0.3-1.2
Short access day 10 total locomotion2.62.83.2-1.5-1.7-1.8
Short access total locomotion5.15.36.6-2.6-1.9-2.3
Compulsive drug intake4.04.06.4-2.5-1.4-1.9
One hour access (0.3 mA shock)0.50.61.11.00.40.7
One hour access (shock baseline)3.84.46.72.61.42.1
Number of responses in last shaping day0.30.30.5-0.5-0.7-0.3
Context. condit. distance diff. score2.12.64.1-2.0-1.3-1.5
Locomotion velocity, session 10.70.82.3-0.1-1.5-0.1
Locomotion distance, session 11.31.73.7-1.9-0.8-0.9
Locomotion velocity, session 20.70.92.10.0-1.5-0.7
Locomotion distance, session 22.02.93.6-1.6-1.9-1.6
Locomotion velocity, session 30.80.92.3-1.5-0.5-0.5
Locomotion distance, session 30.40.40.90.50.20.9
Stereotopy head waving bouts, day 31.51.82.5-1.6-1.1-1.3
Stereotopy head waving duration, day 32.63.24.4-2.1-1.6-1.6
Locomotion velocity, session 70.30.41.0-0.0-1.00.3
Locomotion distance, session 71.11.42.6-1.2-1.6-0.5
Stereotopy head waving bouts, day 70.10.20.30.00.50.4
Stereotopy head waving duration, day 70.50.61.00.31.00.8
Locomotion velocity, session 82.42.94.0-1.2-2.0-1.8
Locomotion distance, session 87.411.014.1-3.8-2.9-3.2
Degree of sensitization distance5.65.75.9-2.4-2.3-2.4
Degree of sensitization stereotypy1.01.11.80.81.30.9
Condit. Reinf. active minus inactive responses0.40.41.0-0.1-1.00.6
Condit. Reinf. active-inactive response ratio1.61.75.1-0.2-2.3-0.2
Condit. Reinf. active responses0.30.40.8-0.5-0.90.2
Condit. Reinf. inactive responses0.30.41.1-0.21.10.1
Incentive salience index mean0.40.51.30.5-0.31.1
Condit. Reinf. lever presses0.40.51.20.60.31.1
Time in familiar zone, hab. session 11.11.12.0-0.6-0.9-1.4
Time in novel zone, hab. session 10.90.91.50.61.20.9
Total zone transitions, hab. session 10.81.22.3-0.7-1.5-0.8
Total locomotion distance, hab. session 10.10.10.2-0.2-0.50.1
Locomotion velocity, hab. session 10.20.30.7-0.4-0.80.1
Time in familiar zone, hab. session 23.23.44.2-1.9-1.5-2.1
Time in novel zone, hab. session 22.32.33.21.81.21.5
Total zone transitions, hab. session 20.10.10.20.2-0.40.3
Total locomotion distance, hab. session 20.20.30.50.7-0.30.5
Locomotion velocity, hab. session 20.40.50.80.9-0.00.8
Novel to familiar place preference ratio1.51.62.71.4-0.11.7
Novelty place preference1.31.42.51.3-0.11.6
Time in novel zone, NPP test1.11.12.01.2-0.11.4
Total zone transitions, NPP test0.20.30.9-0.90.3-0.1
Total locomotion distance, NPP test0.10.10.1-0.30.30.3
Locomotion velocity, NPP test0.20.20.4-0.00.50.6
Pavlov. Cond. lever latency0.20.30.60.80.10.6
Pavlov. Cond. magazine entry latency1.11.51.5-1.2-1.2-1.2
Pavlov. Cond. change in total contacts0.40.50.90.90.00.7
Pavlov. Cond. index score1.01.31.9-1.4-0.9-1.1
Pavlov. Cond. latency score1.01.31.7-1.3-0.9-1.2
Pavlov. Cond. lever contacts0.40.50.6-0.8-0.6-0.7
Pavlov. Cond. magazine entry number1.41.72.71.21.61.0
Pavlov. Cond. intertrial magazine entries1.01.22.9-0.31.70.8
Pavlov. Cond. lever-magazine prob. diff.1.11.42.1-1.5-0.9-1.2
Pavlov. Cond. response bias0.20.20.3-0.6-0.5-0.2
Bone: apparent density0.30.51.0-1.00.5-0.6
Bone surface0.40.61.30.41.10.7
Bone volume0.20.30.80.20.90.2
Bone: connectivity density0.30.51.1-1.10.5-0.3
Bone: cortical apparent density0.00.00.10.3-0.10.0
Bone: cortical area3.45.27.01.92.62.2
Bone: cortical porosity0.60.71.50.41.20.7
Bone: cortical porosity0.20.20.50.10.70.2
Bone: cortical thickness2.64.47.51.42.71.9
Bone: cortical thickness0.50.50.8-0.90.90.1
Bone: cortical tissue density0.00.00.10.3-0.10.1
Bone: elastic displacement0.60.60.9-0.90.5-1.0
Bone: elastic work0.70.92.5-0.21.6-0.3
Bone: endosteal estimation0.00.10.10.30.3-0.0
Bone: endosteal perimeter0.81.62.01.21.41.2
Bone: final force0.10.20.20.50.40.4
Bone: final moment0.30.40.70.60.90.3
Bone: marrow area0.00.00.10.30.20.0
Bone: maximum diameter3.56.57.92.82.22.6
Bone: maximum force0.10.30.60.40.80.0
Bone: maximum moment0.30.61.40.51.20.0
Bone: minimum diameter0.10.20.6-0.20.8-0.0
Bone: periosteal estimation0.91.92.81.31.71.2
Bone: periosteal perimeter3.04.95.92.02.42.2
Bone: post-yield work0.30.40.80.90.5-0.3
Bone: stiffness0.10.10.2-0.4-0.50.1
Bone: tissue strength0.70.72.0-0.10.1-1.4
Bone: trabecular number0.30.51.0-0.71.0-0.1
Bone: trabecular spacing0.50.71.81.4-0.30.4
Bone: trabecular thickness1.01.22.3-1.50.6-1.0
Bone: trabecular tissue density0.30.40.80.1-0.9-0.6
Breakpoint value in progressive ratio session0.50.61.20.70.11.1
Distance traveled before self-admin0.10.10.20.2-0.30.4
Distance traveled after self-admin0.30.30.50.60.20.7
Delta time in closed arm before/after self-admin2.62.55.7-2.4-0.5-1.3
Delta time in open arm before/after self-admin4.03.88.12.81.11.5
Diff in mean of infusions in LGA sessions0.20.30.50.50.30.7
Extinction: sum of active levers before priming1.61.63.31.20.21.8
Active lever presses in extinction session 62.12.02.70.91.71.6
Delta distance traveled before/after self-admin0.20.20.20.40.50.4
Delta ambulatory time before/after self-admin0.00.00.1-0.10.2-0.2
Time in closed arm before self-admin0.60.61.5-0.3-0.6-1.2
Time in closed arm after self-admin2.52.64.8-2.2-0.7-1.6
Time in open arm before self-admin0.30.30.4-0.60.30.6
Time in open arm after self-admin0.80.91.51.2-0.01.0
Sum of active levers in priming session hrs 5-62.02.04.10.91.02.0
Time to tail flick, vehicle, before self-admin0.30.30.70.50.8-0.3
Time to tail flick, vehicle, after self-admin0.00.00.1-0.1-0.1-0.2
Time to tail flick, test, before self-admin1.31.31.5-1.2-1.2-1.0
Time to tail flick, test, after self-admin0.80.91.21.01.10.7
Delta time to tail flick, vehicle, before/after SA0.30.20.6-0.3-0.8-0.3
Delta time to tail flick, test, before/after SA1.41.21.31.11.11.1
Ambulatory time before self-admin0.00.00.00.2-0.00.2
Ambulatory time after self-admin0.20.20.30.50.10.6
Total heroin consumption0.00.00.0-0.20.1-0.1
Area under the delay curve7.98.511.03.32.62.8
Delay disc. indifference point, 0s delay7.07.69.12.42.83.0
Delay disc. indifference point, 16s delay4.64.77.42.71.71.9
Delay disc. indifference point, 2s delay6.26.98.02.42.82.7
Delay disc. indifference point, 24s delay3.43.34.42.11.31.9
Delay disc. indifference point, 4s delay5.15.46.12.22.32.5
Delay disc. indifference point, 8s delay1.51.53.21.80.61.0
Delay discount exponential model param7.37.810.1-3.2-2.4-2.7
Delay discount hyperbolic model param7.78.210.0-3.2-2.6-2.8
Fecal boli incidents, locomotor time 10.60.61.0-0.7-1.0-0.6
Change in fecal boli incidents, locomotor task1.31.22.9-0.2-1.7-0.8
Time >=10cm from walls, locomotor time 10.00.00.00.00.2-0.2
Bouts of movement, locomotor time 10.20.20.40.3-0.40.6
Total resting periods, locomotor time 10.40.40.70.5-0.60.8
Rest time, locomotor task time 10.40.51.4-0.2-1.2-0.1
Distance moved, locomotor task time 10.40.51.20.31.1-0.3
Vertical activity count, locomotor time 10.20.20.40.30.4-0.6
Time >=10cm from walls, locomotor time 20.30.30.4-0.6-0.4-0.6
Bouts of movement, locomotor time 20.40.40.6-0.50.60.8
Total resting periods, locomotor time 20.40.40.8-0.50.30.9
Rest time, locomotor task time 20.80.92.1-0.7-1.4-0.6
Distance moved, locomotor task time 20.10.10.2-0.00.5-0.3
Vertical activity count, locomotor time 20.10.20.40.10.60.3
Weight adjusted by age1.31.42.20.91.51.1
Seeking ratio, delayed vs. immediate footshock0.20.20.7-0.0-0.8-0.2
Locomotion in novel chamber0.20.30.7-0.8-0.0-0.4
Locomotion in novel chamber post-restriction2.02.44.3-1.3-2.1-1.2
Progressive ratio0.80.91.31.11.0-0.6
Food seeking constrained by brief footshock3.84.77.32.12.71.6
Seeking ratio, punishment vs. effort0.91.12.80.00.81.7
Run reversals in cocaine runway, females0.20.20.30.2-0.5-0.6
Run reversals in cocaine runway, males0.10.10.20.20.10.4
Latency to leave start box in cocaine runway0.20.30.60.10.40.8
Latency to leave start box in cocaine runway, F0.30.40.50.20.70.7
Latency to leave start box in cocaine runway, M0.10.10.1-0.1-0.30.4
Cd content in liver1.11.21.2-1.1-1.1-1.1
Co content in liver0.30.30.90.20.31.0
Cu content in liver0.10.10.30.00.20.6
Fe content in liver1.51.84.7-0.5-2.2-0.7
K content in liver1.81.83.30.51.81.3
Mg content in liver3.03.14.11.22.01.9
Mn content in liver0.70.82.3-0.01.50.5
Na content in liver5.15.47.62.71.22.8
Rb content in liver1.21.41.61.11.21.2
Se content in liver2.32.84.11.62.01.3
Sr content in liver0.60.61.31.2-0.50.3
Zn content in liver0.10.10.10.30.2-0.2