Hub : Genes

Tbc1d10a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr14:79074168:79078538 0.06 0.04 8.2e-03 0 0.02 0 0 2.7e-01 1.8e-02 3.3e-01 3.3e-01
2 OFC gene expression ENSRNOG00000006394 0.21 0.1 4.5e-04 0.06 0.08 0.06 0.04 1.4e-02 6.4e-03 1.5e-02 3.7e-02
3 PL gene expression ENSRNOG00000006394 0.07 0.05 3.2e-04 0.02 0.05 0.04 0.04 7.3e-03 1.4e-04 7.4e-04 4.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.92.86.41.3-2.5-0.7
BMI without tail0.30.71.50.5-1.20.5
Body weight1.56.311.92.2-3.4-1.4
Epididymis fat weight0.10.30.6-0.3-0.80.3
Glucose17.727.138.85.6-3.4-6.2
Heart weight0.10.10.20.10.50.0
Left kidney weight0.51.42.8-1.00.71.7
Right kidney weight1.13.34.8-2.20.62.2
Tail length0.10.30.40.4-0.60.7
Length with tail0.41.52.21.4-1.5-0.5
Length without tail1.22.52.71.6-1.5-1.6
Liver weight, left5.79.111.5-3.42.53.1
Liver weight, right4.37.210.4-2.62.13.2
Parametrial fat weight1.73.45.81.6-1.3-2.4
Retroperitoneal fat weight0.10.30.40.4-0.6-0.6
Intraocular pressure0.60.91.91.4-0.0-0.8
Extensor digitorum longus weight1.97.511.02.9-3.3-1.7
Soleus weight0.31.02.01.4-0.90.2
Tibialis anterior weight1.44.86.02.4-2.3-1.8
Tibia length0.31.02.0-1.00.11.4
Number of licking bursts0.60.70.90.9-1.0-0.6
Food consumed during 24 hour testing period1.01.22.41.50.3-1.0
Times rat made contact with spout1.11.21.91.10.8-1.4
Mean time between licks in bursts0.50.71.50.51.2-0.6
Mean num. licks in bursts0.60.72.1-0.21.4-0.3
Std. dev. time between licks in bursts0.81.01.8-0.81.30.7
Water consumed over 24 hours0.81.01.70.81.3-0.8
Indifference point 0 sec0.10.10.20.4-0.3-0.3
Indifference point AUC0.20.30.8-0.10.90.2
Indifference point function ln k0.30.40.6-0.80.10.7
Indifference point function log k0.30.40.6-0.80.10.7
Delay discounting total patch changes 0 sec0.20.30.60.8-0.4-0.5
Delay discounting total patch changes 12 sec0.10.10.20.3-0.4-0.2
Delay discounting total patch changes 18 sec1.11.42.31.5-0.6-1.3
Delay discounting total patch changes 24 sec0.70.91.6-0.61.30.8
Delay discounting total patch changes 6 sec0.20.20.50.7-0.0-0.4
Delay discounting time to switch 0 sec0.10.10.4-0.1-0.6-0.1
Delay discounting water rate 0 sec0.81.23.31.8-0.3-0.5
Delay discounting water rate 12 sec0.20.30.50.60.40.7
Delay discounting water rate 18 sec2.02.65.6-1.01.12.4
Delay discounting water rate 24 sec0.60.82.01.40.50.3
Delay discounting water rate 6 sec0.40.50.80.90.30.9
Locomotor activity0.61.01.91.40.1-1.1
Locomotor testing distance0.10.20.20.4-0.50.3
Locomotor testing rearing1.32.02.71.7-1.3-1.3
Light reinforcement 10.30.50.80.7-0.90.3
Light reinforcement 20.20.30.80.4-0.10.9
Reaction time number correct0.50.71.30.91.10.1
Reaction time mean minus median0.20.30.80.3-0.0-0.9
Reaction time mean minus median AUC0.30.40.50.6-0.7-0.6
Reaction time num false alarms0.60.82.20.2-1.5-0.3
Reaction time num false alarms AUC0.50.72.10.1-1.40.0
Reaction time trials correct on left0.50.71.30.91.10.1
Reaction time trials on left0.50.71.40.81.20.1
Reaction time mean0.10.10.3-0.5-0.1-0.4
Reaction time mean AUC0.10.20.5-0.70.0-0.1
Median of all reaction times0.20.20.7-0.8-0.0-0.1
Reaction time omissions0.10.20.4-0.60.30.4
Reaction time false alarm rate0.91.33.6-0.3-1.90.1
Reaction time premature initiation rate3.95.37.1-2.21.92.7
Reaction time premature initiations2.53.64.6-1.32.12.2
Std. dev. reaction times0.30.40.90.4-0.3-1.0
Reaction time trials completed0.50.71.40.81.20.1
Reaction time trials AUC0.40.61.30.81.10.1
Social response proportion1.11.21.91.40.2-1.3
Social responses1.21.62.71.6-0.1-1.4
Social time0.20.30.7-0.10.9-0.4
Conditioned locomotion0.81.02.1-1.40.10.9
Cocaine response after cond. corrected0.40.40.80.1-0.9-0.6
Cocaine response after cond. not corrected0.70.82.00.3-1.4-0.5
Cocaine response before conditioning0.10.10.20.2-0.20.4
Saline control response0.40.61.2-0.41.10.6
Condit. Reinf. active minus inactive responses0.50.61.0-0.20.91.0
Condit. Reinf. active-inactive response ratio0.00.00.0-0.2-0.2-0.0
Condit. Reinf. active responses1.21.62.6-0.81.61.3
Condit. Reinf. inactive responses1.51.93.4-0.81.91.3
Condit. Reinf. lever presses0.40.50.9-0.30.61.0
Condit. Reinf. lever reinforcers received0.91.31.7-0.81.31.2
Pavlov. Cond. lever latency0.81.02.50.6-1.6-0.5
Pavlov. Cond. magazine entry latency0.00.00.10.3-0.10.1
Pavlov. Cond. change in total contacts0.30.41.0-0.21.00.5
Pavlov. Cond. index score0.40.51.1-0.41.00.7
Pavlov. Cond. latency score0.50.71.2-0.41.10.8
Pavlov. Cond. lever contacts1.01.53.2-0.81.80.7
Pavlov. Cond. magazine entry number0.10.20.5-0.70.00.2
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.50.10.1
Pavlov. Cond. lever-magazine prob. diff.0.50.71.2-0.41.10.8
Pavlov. Cond. response bias0.30.51.3-0.21.10.2
Conditioned reinforcement - actives1.91.92.71.0-1.7-1.4
Conditioned reinforcement - inactives2.12.43.21.3-1.8-1.5
Conditioned locomotion0.30.40.70.5-0.8-0.4
Intermittent access intake day 1-15 change1.61.62.51.1-1.0-1.6
Intermittent access intake escalation1.01.01.80.8-0.7-1.3
Intermittent access intake escalation 20.30.30.50.70.2-0.5
Intermitt. access day 1 inactive lever presses0.30.30.4-0.40.50.7
Intermitt. access day 15 inactive lever presses2.02.24.62.1-0.8-1.1
Intermitt. access escalation Index0.00.00.10.30.10.0
Intermittent access day 1 total infusions0.40.51.00.5-1.0-0.5
Intermittent access day 15 total infusions2.02.32.61.3-1.6-1.6
Intermittent access terminal intake (last 3 days)0.91.01.11.0-0.9-1.1
Intermittent access total infusions0.60.70.80.7-0.9-0.9
Intermittent access day 1 locomotion0.70.81.0-0.91.00.7
Intermittent access day 15 total locomotion3.13.34.71.6-2.2-1.7
Intermittent access total locomotion0.80.91.10.7-1.0-1.1
Intermittent access standard deviation0.20.30.50.10.70.6
Cocaine induced anxiety1.01.22.21.5-0.4-1.1
Post-drug Anxiety0.70.81.11.0-0.5-1.0
Baseline Anxiety0.80.81.20.3-1.1-1.1
Lifetime Intake0.40.50.70.5-0.8-0.7
Incentive Sensitization - Responses1.11.11.51.0-0.9-1.2
Incentive Sensitization - Breakpoint1.11.11.41.1-0.9-1.2
Progressive ratio test 1 active lever presses1.31.31.90.6-1.3-1.4
Progressive ratio test 1 breakpoint0.90.91.40.3-1.2-1.1
Progressive ratio test 1 inactive lever presses2.32.43.01.5-1.7-1.5
Progressive ratio test 2 active lever presses1.11.21.70.8-1.1-1.3
Progressive ratio test 2 breakpoint1.11.32.00.9-1.0-1.4
Progressive ratio test 2 inactive lever presses5.05.87.32.7-2.3-2.2
Total sessions with >9 infusions0.10.10.3-0.20.10.6
Short access day 1 total inactive lever presses0.80.91.61.3-0.9-0.5
Short access day 10 total inactive lever presses0.80.91.5-0.50.91.2
Short access day 1 total infusions0.20.20.2-0.4-0.30.5
Short access day 10 total infusions0.20.20.3-0.40.40.5
Short access total infusions0.20.20.4-0.40.00.6
Short access day 1 locomotion2.22.33.8-1.11.31.9
Short access day 10 total locomotion3.03.24.6-1.72.11.5
Short access total locomotion5.75.86.8-2.02.62.6
Compulsive drug intake5.15.17.2-2.72.11.9
One hour access (0.3 mA shock)0.50.61.10.4-0.7-1.0
One hour access (shock baseline)3.84.35.51.9-2.0-2.4
Number of responses in last shaping day0.10.10.3-0.50.10.3
Context. condit. distance diff. score1.72.02.2-1.51.41.4
Locomotion velocity, session 10.40.40.70.50.5-0.8
Locomotion distance, session 11.82.32.7-1.71.31.6
Locomotion velocity, session 20.91.01.9-0.01.4-1.1
Locomotion distance, session 21.42.03.4-1.41.90.7
Locomotion velocity, session 31.11.31.7-1.30.81.2
Locomotion distance, session 30.40.40.40.7-0.6-0.6
Stereotopy head waving bouts, day 31.41.72.2-1.21.51.2
Stereotopy head waving duration, day 31.92.32.9-1.41.71.5
Locomotion velocity, session 70.10.10.10.30.1-0.2
Locomotion distance, session 70.50.61.1-1.00.80.4
Stereotopy head waving bouts, day 70.10.10.2-0.2-0.5-0.0
Stereotopy head waving duration, day 70.20.30.80.2-0.90.1
Locomotion velocity, session 81.11.33.6-0.61.90.1
Locomotion distance, session 85.58.210.9-2.73.32.5
Degree of sensitization distance3.83.85.6-1.92.41.5
Degree of sensitization stereotypy0.50.51.20.5-1.1-0.3
Condit. Reinf. active minus inactive responses0.20.30.60.4-0.2-0.8
Condit. Reinf. active-inactive response ratio0.50.61.20.50.5-1.1
Condit. Reinf. active responses0.00.00.00.20.0-0.2
Condit. Reinf. inactive responses0.10.20.40.1-0.30.6
Incentive salience index mean0.70.90.91.0-0.9-1.0
Condit. Reinf. lever presses0.70.91.31.0-1.2-0.5
Time in familiar zone, hab. session 10.60.61.2-0.51.10.6
Time in novel zone, hab. session 10.20.20.50.4-0.7-0.1
Total zone transitions, hab. session 10.40.51.2-0.41.10.4
Total locomotion distance, hab. session 10.10.10.3-0.40.50.0
Locomotion velocity, hab. session 10.10.10.2-0.30.4-0.1
Time in familiar zone, hab. session 22.52.63.3-1.81.71.3
Time in novel zone, hab. session 22.72.85.12.3-1.4-1.1
Total zone transitions, hab. session 20.20.20.60.8-0.1-0.3
Total locomotion distance, hab. session 20.71.02.01.4-0.3-0.9
Locomotion velocity, hab. session 20.81.11.81.4-0.6-1.0
Novel to familiar place preference ratio1.92.02.81.3-1.3-1.7
Novelty place preference1.81.82.41.3-1.2-1.6
Time in novel zone, NPP test1.51.62.01.3-1.1-1.4
Total zone transitions, NPP test0.40.50.8-0.90.20.9
Total locomotion distance, NPP test0.10.10.2-0.5-0.10.1
Locomotion velocity, NPP test0.10.10.2-0.5-0.4-0.2
Pavlov. Cond. lever latency0.30.40.80.4-0.2-0.9
Pavlov. Cond. magazine entry latency0.91.21.8-0.91.31.0
Pavlov. Cond. change in total contacts0.60.70.80.8-0.7-0.9
Pavlov. Cond. index score0.91.21.3-1.01.01.1
Pavlov. Cond. latency score0.81.11.4-0.91.01.2
Pavlov. Cond. lever contacts0.20.30.5-0.30.40.7
Pavlov. Cond. magazine entry number0.81.01.70.8-1.3-0.8
Pavlov. Cond. intertrial magazine entries0.40.50.5-0.7-0.70.7
Pavlov. Cond. lever-magazine prob. diff.1.01.21.5-1.11.11.2
Pavlov. Cond. response bias0.20.20.2-0.50.40.4
Bone: apparent density1.11.93.3-1.81.01.2
Bone surface0.10.10.3-0.1-0.5-0.2
Bone volume0.10.10.3-0.5-0.10.1
Bone: connectivity density0.81.32.2-1.50.61.1
Bone: cortical apparent density0.00.10.20.1-0.4-0.1
Bone: cortical area3.04.66.42.5-2.5-1.1
Bone: cortical porosity0.10.10.2-0.3-0.40.2
Bone: cortical porosity0.10.10.1-0.3-0.20.3
Bone: cortical thickness1.72.95.31.8-2.3-0.4
Bone: cortical thickness0.70.81.7-0.8-0.31.3
Bone: cortical tissue density0.10.10.20.2-0.4-0.3
Bone: elastic displacement0.70.81.6-0.70.61.3
Bone: elastic work0.40.51.40.2-0.21.2
Bone: endosteal estimation0.00.10.20.40.10.0
Bone: endosteal perimeter0.61.21.81.3-1.0-0.8
Bone: final force0.40.61.31.2-0.7-0.0
Bone: final moment0.30.51.11.0-0.7-0.0
Bone: marrow area0.00.10.10.40.1-0.0
Bone: maximum diameter4.98.913.63.7-2.8-2.3
Bone: maximum force0.20.41.01.0-0.50.2
Bone: maximum moment0.20.30.80.9-0.30.2
Bone: minimum diameter0.10.10.30.30.10.6
Bone: periosteal estimation0.91.83.21.8-1.3-0.5
Bone: periosteal perimeter2.54.15.42.3-2.3-1.2
Bone: post-yield work0.10.20.30.30.2-0.6
Bone: stiffness0.00.00.10.0-0.20.2
Bone: tissue strength0.50.50.70.80.80.3
Bone: trabecular number0.71.12.2-1.50.41.0
Bone: trabecular spacing1.72.34.62.2-0.7-1.2
Bone: trabecular thickness2.93.56.2-2.51.21.7
Bone: trabecular tissue density0.10.20.40.10.3-0.6
Breakpoint value in progressive ratio session0.30.30.50.4-0.5-0.7
Distance traveled before self-admin0.30.30.4-0.60.60.3
Distance traveled after self-admin0.10.10.2-0.2-0.4-0.1
Delta time in closed arm before/after self-admin4.64.46.1-2.51.82.0
Delta time in open arm before/after self-admin6.15.86.62.6-2.2-2.5
Diff in mean of infusions in LGA sessions0.20.20.3-0.5-0.6-0.2
Extinction: sum of active levers before priming1.41.42.80.5-1.1-1.7
Active lever presses in extinction session 60.60.61.2-0.3-1.1-0.6
Delta distance traveled before/after self-admin0.40.51.00.3-1.0-0.5
Delta ambulatory time before/after self-admin0.10.10.3-0.5-0.3-0.2
Time in closed arm before self-admin0.20.20.50.10.40.7
Time in closed arm after self-admin3.43.54.3-1.91.72.1
Time in open arm before self-admin0.10.10.1-0.40.10.4
Time in open arm after self-admin2.02.22.71.6-1.1-1.7
Sum of active levers in priming session hrs 5-60.90.81.60.4-1.3-0.9
Time to tail flick, vehicle, before self-admin0.20.30.50.5-0.7-0.1
Time to tail flick, vehicle, after self-admin0.20.20.4-0.60.30.5
Time to tail flick, test, before self-admin0.80.81.2-0.41.11.1
Time to tail flick, test, after self-admin0.91.02.61.6-0.60.0
Delta time to tail flick, vehicle, before/after SA0.40.40.7-0.90.60.2
Delta time to tail flick, test, before/after SA1.21.11.81.3-0.9-0.8
Ambulatory time before self-admin0.50.50.9-0.90.60.4
Ambulatory time after self-admin0.20.30.7-0.90.0-0.2
Total heroin consumption0.00.00.1-0.30.10.1
Area under the delay curve7.37.811.82.2-3.4-2.6
Delay disc. indifference point, 0s delay5.25.612.20.9-3.5-2.0
Delay disc. indifference point, 16s delay5.65.77.61.9-2.4-2.8
Delay disc. indifference point, 2s delay3.53.99.01.0-3.0-1.3
Delay disc. indifference point, 24s delay4.24.16.21.1-2.5-2.2
Delay disc. indifference point, 4s delay3.13.36.21.3-2.5-1.4
Delay disc. indifference point, 8s delay2.32.43.01.7-1.5-1.4
Delay discount exponential model param6.97.311.1-2.23.32.4
Delay discount hyperbolic model param7.07.411.8-2.23.42.4
Fecal boli incidents, locomotor time 10.50.51.1-0.61.10.3
Change in fecal boli incidents, locomotor task0.30.30.80.10.9-0.2
Time >=10cm from walls, locomotor time 10.20.20.3-0.3-0.6-0.2
Bouts of movement, locomotor time 10.50.51.00.4-0.6-1.0
Total resting periods, locomotor time 10.70.81.40.7-0.8-1.2
Rest time, locomotor task time 10.10.10.20.50.3-0.2
Distance moved, locomotor task time 10.10.10.1-0.20.10.4
Vertical activity count, locomotor time 10.30.30.5-0.70.5-0.0
Time >=10cm from walls, locomotor time 20.10.10.2-0.50.40.1
Bouts of movement, locomotor time 20.20.20.4-0.2-0.60.3
Total resting periods, locomotor time 20.20.20.5-0.1-0.70.2
Rest time, locomotor task time 20.20.20.5-0.10.70.4
Distance moved, locomotor task time 20.00.00.0-0.1-0.0-0.0
Vertical activity count, locomotor time 20.10.10.3-0.6-0.1-0.3
Weight adjusted by age1.11.22.31.2-1.5-0.1
Seeking ratio, delayed vs. immediate footshock0.40.51.3-0.41.10.1
Locomotion in novel chamber0.70.91.3-1.10.31.1
Locomotion in novel chamber post-restriction0.70.81.4-1.01.20.2
Progressive ratio0.10.10.10.3-0.2-0.3
Food seeking constrained by brief footshock1.21.53.40.8-1.8-0.6
Seeking ratio, punishment vs. effort0.30.40.90.4-0.90.0
Run reversals in cocaine runway, females0.20.20.4-0.70.1-0.3
Run reversals in cocaine runway, males0.00.00.10.3-0.1-0.0
Latency to leave start box in cocaine runway0.10.10.2-0.3-0.40.0
Latency to leave start box in cocaine runway, F0.30.30.60.4-0.80.3
Latency to leave start box in cocaine runway, M0.40.41.0-1.00.5-0.3
Cd content in liver0.80.91.0-0.90.91.0
Co content in liver0.20.20.4-0.2-0.7-0.2
Cu content in liver0.10.20.3-0.5-0.3-0.3
Fe content in liver0.60.71.8-0.11.3-0.6
K content in liver0.50.51.4-0.3-1.20.0
Mg content in liver1.71.83.31.0-1.8-0.9
Mn content in liver0.30.30.6-0.7-0.10.6
Na content in liver5.35.66.72.2-2.3-2.6
Rb content in liver0.70.91.50.7-1.2-0.8
Se content in liver1.11.31.71.1-1.3-1.0
Sr content in liver1.91.73.71.9-0.5-1.1
Zn content in liver0.30.31.01.00.20.0