Hub : Genes

Tmem117

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000006068 0.33 0.13 0.0e+00 0.24 0.25 0.23 0.24 3.2e-26 4.8e-27 8.0e-26 8.6e-27
2 BLA gene expression ENSRNOG00000006068 0.33 0.15 3.1e-05 0.04 0.08 0.07 0.06 5.2e-03 5.6e-05 1.5e-04 2.7e-04
3 BLA mRNA stability ENSRNOG00000006068 0.47 0.11 0.0e+00 0.51 0.52 0.51 0.54 3.1e-31 1.8e-32 5.6e-31 3.5e-34
4 Brain gene expression ENSRNOG00000006068 0.49 0.12 7.0e-15 0.04 0.18 0.17 0.16 1.3e-04 1.3e-16 2.3e-15 6.5e-15
5 Brain mRNA stability ENSRNOG00000006068 0.67 0.09 0.0e+00 0.57 0.64 0.63 0.64 2.3e-63 6.2e-78 3.0e-75 5.2e-76
6 IL mRNA stability ENSRNOG00000006068 0.71 0.15 6.7e-16 0.44 0.41 0.42 0.39 8.0e-12 4.5e-11 2.6e-11 2.4e-10
7 LHb gene expression ENSRNOG00000006068 0.63 0.17 9.5e-04 0.06 0.12 0.07 0.04 1.8e-02 9.7e-04 9.7e-03 3.1e-02
8 LHb mRNA stability ENSRNOG00000006068 0.31 0.2 1.1e-03 0.14 0.09 0.11 0.12 4.5e-04 3.4e-03 1.7e-03 8.8e-04
9 NAcc gene expression ENSRNOG00000006068 0.37 0.12 6.2e-12 0.06 0.16 0.13 0.15 1.8e-05 9.7e-12 3.7e-10 4.0e-11
10 NAcc mRNA stability ENSRNOG00000006068 0.26 0.12 0.0e+00 0.29 0.31 0.3 0.3 1.5e-21 3.4e-23 1.9e-22 1.7e-22
11 OFC mRNA stability ENSRNOG00000006068 0.83 0.1 9.9e-15 0.26 0.31 0.34 0.34 5.9e-07 3.2e-08 7.0e-09 5.6e-09
12 PL gene expression ENSRNOG00000006068 0.43 0.13 4.4e-12 0.09 0.15 0.13 0.12 1.3e-07 2.2e-11 4.5e-10 1.0e-09
13 PL mRNA stability ENSRNOG00000006068 0.47 0.08 0.0e+00 0.54 0.58 0.58 0.58 9.9e-49 3.5e-54 3.2e-54 2.9e-54

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
BMI with tail0.82.63.92.01.61.61.22.01.80.31.91.71.81.80.21.8
BMI without tail2.14.56.92.62.61.81.82.32.30.82.42.62.22.10.72.1
Body weight0.62.74.31.91.41.90.92.11.80.01.81.61.91.9-0.12.0
Epididymis fat weight0.41.03.0-0.2-1.50.9-1.40.60.0-1.60.1-1.00.20.4-1.70.6
Glucose0.10.10.4-0.30.1-0.7-0.1-0.6-0.30.2-0.3-0.2-0.5-0.40.3-0.5
Heart weight1.62.23.61.81.41.41.11.51.9-0.11.81.51.71.8-0.21.7
Left kidney weight0.51.42.41.20.41.4-0.11.31.4-1.01.30.61.41.6-1.11.4
Right kidney weight0.61.83.21.40.21.50.11.51.6-1.11.60.61.71.8-1.41.6
Tail length1.03.04.42.11.41.90.92.12.1-0.32.01.62.12.1-0.42.0
Length with tail0.31.01.80.8-0.21.3-0.51.11.0-1.30.90.01.11.2-1.31.2
Length without tail0.71.54.0-1.0-2.0-0.1-1.8-0.5-0.6-1.8-0.7-1.8-0.5-0.3-1.8-0.4
Liver weight, left0.81.23.00.8-0.41.2-0.81.01.1-1.71.1-0.21.11.2-1.71.2
Liver weight, right0.71.13.00.5-0.91.4-0.81.10.7-1.40.8-0.30.91.1-1.71.1
Parametrial fat weight1.22.43.91.81.81.51.71.81.51.01.52.01.51.50.81.5
Retroperitoneal fat weight0.00.10.3-0.20.3-0.30.1-0.3-0.30.4-0.30.1-0.4-0.30.5-0.3
Intraocular pressure2.13.010.0-0.51.5-1.72.2-1.4-0.63.2-0.91.1-1.2-1.43.0-1.4
Extensor digitorum longus weight0.31.14.00.2-0.80.7-1.50.60.6-2.00.5-0.80.60.8-1.90.6
Soleus weight2.47.010.23.12.13.01.53.22.9-0.33.12.53.13.2-0.53.2
Tibialis anterior weight1.13.75.82.00.52.4-0.02.42.2-1.52.20.92.32.4-1.72.3
Tibia length2.15.99.1-3.0-2.5-2.5-2.0-2.7-2.0-0.4-3.0-2.8-2.8-2.7-0.3-2.7
Number of licking bursts0.40.50.9-0.7-0.1-0.9-0.3-0.9-1.00.3-0.7-0.4-0.9-0.90.5-0.9
Food consumed during 24 hour testing period0.30.31.00.11.0-0.60.6-0.30.30.8-0.10.5-0.2-0.31.0-0.4
Times rat made contact with spout0.20.20.7-0.40.2-0.8-0.3-0.60.10.0-0.5-0.3-0.6-0.60.3-0.7
Mean time between licks in bursts0.00.10.20.1-0.10.40.20.4-0.40.3-0.00.20.20.10.20.2
Mean num. licks in bursts0.00.00.2-0.1-0.2-0.1-0.3-0.10.4-0.3-0.2-0.3-0.1-0.1-0.2-0.1
Std. dev. time between licks in bursts1.41.63.0-1.4-0.6-1.6-0.5-1.5-1.70.5-1.5-0.9-1.5-1.50.8-1.6
Water consumed over 24 hours1.41.63.7-1.3-0.2-1.9-0.4-1.8-1.00.5-1.4-0.8-1.6-1.60.9-1.7
Indifference point 0 sec0.10.20.7-0.4-0.9-0.1-0.6-0.0-0.0-0.6-0.3-0.6-0.2-0.1-0.7-0.1
Indifference point AUC0.20.20.6-0.2-0.50.4-0.80.20.1-0.7-0.2-0.5-0.00.0-0.70.1
Indifference point function ln k0.40.60.90.90.61.00.70.90.80.20.90.80.90.80.10.9
Indifference point function log k0.40.60.90.90.61.00.70.90.80.20.90.80.90.80.10.9
Delay discounting total patch changes 0 sec0.00.10.3-0.2-0.5-0.1-0.30.0-0.0-0.2-0.3-0.3-0.1-0.1-0.3-0.1
Delay discounting total patch changes 12 sec0.10.10.2-0.10.2-0.20.2-0.10.10.5-0.30.2-0.3-0.30.4-0.3
Delay discounting total patch changes 18 sec0.10.10.50.30.20.2-0.10.30.7-0.30.30.20.30.3-0.30.3
Delay discounting total patch changes 24 sec0.00.00.30.20.5-0.2-0.10.0-0.0-0.10.10.3-0.0-0.10.3-0.1
Delay discounting total patch changes 6 sec1.11.72.5-1.5-1.4-1.2-1.5-1.3-1.1-0.7-1.4-1.6-1.4-1.4-0.5-1.3
Delay discounting time to switch 0 sec0.30.41.7-0.2-0.8-0.0-1.0-0.0-0.2-1.30.1-0.80.20.2-1.20.1
Delay discounting water rate 0 sec0.30.41.1-0.6-0.1-0.40.1-0.5-1.00.8-0.8-0.1-0.8-0.80.7-0.6
Delay discounting water rate 12 sec0.60.82.3-1.0-0.6-1.0-0.6-1.0-1.50.0-0.9-0.8-1.0-1.00.2-1.0
Delay discounting water rate 18 sec0.81.01.8-0.90.0-1.30.3-1.2-0.81.1-1.1-0.3-1.2-1.31.1-1.2
Delay discounting water rate 24 sec0.20.31.10.10.8-0.40.7-0.2-0.40.9-0.00.5-0.2-0.31.1-0.2
Delay discounting water rate 6 sec0.71.01.6-1.0-0.4-1.30.1-1.1-1.20.9-1.1-0.5-1.1-1.30.8-1.2
Locomotor activity0.40.72.20.21.3-0.81.1-0.50.41.4-0.00.8-0.3-0.41.5-0.5
Locomotor testing distance0.40.61.7-0.30.6-0.90.9-0.80.11.3-0.30.3-0.6-0.71.2-0.8
Locomotor testing rearing0.30.40.9-0.60.0-0.90.4-0.8-0.20.9-0.5-0.2-0.8-0.90.7-0.8
Light reinforcement 10.71.34.0-0.51.1-1.40.9-0.9-0.81.7-1.00.5-1.0-1.12.0-1.2
Light reinforcement 20.40.61.0-0.8-0.1-1.00.1-0.8-0.80.7-1.0-0.3-0.9-0.90.7-1.0
Reaction time number correct0.81.13.60.21.5-0.91.5-0.60.21.8-0.01.1-0.3-0.51.9-0.5
Reaction time mean minus median1.01.32.1-1.4-1.3-1.1-0.8-1.4-1.3-0.2-1.3-1.3-1.3-1.2-0.2-1.3
Reaction time mean minus median AUC0.30.40.7-0.8-0.7-0.6-0.1-0.8-0.40.1-0.7-0.6-0.7-0.7-0.2-0.7
Reaction time num false alarms0.60.92.70.41.5-0.41.4-0.3-0.21.60.31.2-0.1-0.41.7-0.1
Reaction time num false alarms AUC0.81.23.30.61.8-0.31.6-0.20.11.70.51.50.0-0.21.80.0
Reaction time trials correct on left0.81.13.60.21.5-0.91.5-0.60.21.8-0.01.1-0.3-0.51.9-0.5
Reaction time trials on left0.91.24.00.21.5-1.01.6-0.60.21.9-0.01.1-0.4-0.62.0-0.6
Reaction time mean0.10.20.60.0-0.50.3-0.40.2-0.1-0.70.2-0.30.20.3-0.80.2
Reaction time mean AUC0.10.20.7-0.1-0.70.2-0.50.2-0.2-0.70.0-0.50.20.3-0.90.2
Median of all reaction times0.40.51.10.80.20.80.00.90.5-0.60.90.41.01.0-0.70.9
Reaction time omissions0.91.22.6-1.00.3-1.6-0.2-1.6-1.10.6-1.1-0.4-1.3-1.31.1-1.4
Reaction time false alarm rate0.10.20.40.50.70.40.50.3-0.00.30.50.60.30.20.30.4
Reaction time premature initiation rate1.21.63.9-1.6-2.0-0.9-1.2-1.1-1.0-0.7-1.4-1.7-1.2-1.2-0.9-1.2
Reaction time premature initiations0.81.21.9-1.4-1.3-1.1-0.6-1.3-0.7-0.1-1.2-1.2-1.2-1.3-0.2-1.3
Std. dev. reaction times0.50.71.3-1.0-0.5-1.0-0.3-1.1-1.00.2-0.9-0.6-1.0-0.90.2-1.0
Reaction time trials completed0.91.24.00.21.5-1.01.6-0.60.21.9-0.01.1-0.4-0.62.0-0.6
Reaction time trials AUC0.91.23.90.31.7-0.81.7-0.40.31.90.11.2-0.2-0.42.0-0.4
Social response proportion0.70.72.0-0.7-1.40.2-1.40.0-1.0-1.1-0.5-1.1-0.4-0.1-1.1-0.2
Social responses1.82.44.3-1.8-0.9-1.7-1.3-1.7-2.1-0.1-1.8-1.4-1.9-1.80.4-1.8
Social time0.91.22.9-0.80.6-1.30.5-1.2-1.21.4-1.00.1-1.2-1.31.7-1.2
Conditioned locomotion0.30.41.30.0-0.90.8-0.70.60.4-0.90.2-0.50.30.5-1.10.5
Cocaine response after cond. corrected0.50.50.90.80.40.90.50.80.9-0.21.00.60.90.9-0.30.9
Cocaine response after cond. not corrected0.20.20.60.3-0.30.5-0.30.30.3-0.80.5-0.10.50.5-0.80.5
Cocaine response before conditioning1.62.03.2-1.6-1.1-1.6-1.3-1.6-1.8-0.3-1.7-1.4-1.6-1.60.2-1.6
Saline control response1.21.63.0-1.6-1.7-1.1-1.3-1.2-0.6-0.7-1.4-1.7-1.3-1.2-0.8-1.2
Condit. Reinf. active minus inactive responses0.00.00.00.10.0-0.10.0-0.1-0.1-0.10.1-0.00.10.0-0.20.0
Condit. Reinf. active-inactive response ratio0.40.40.8-0.50.1-0.9-0.1-0.8-0.80.3-0.6-0.2-0.7-0.70.5-0.8
Condit. Reinf. active responses0.60.91.51.10.70.90.71.01.2-0.11.20.81.11.1-0.31.1
Condit. Reinf. inactive responses1.01.22.01.30.91.20.81.31.40.11.41.11.31.2-0.21.3
Condit. Reinf. lever presses0.50.71.70.91.30.31.10.50.90.80.81.10.60.50.80.5
Condit. Reinf. lever reinforcers received0.50.71.11.01.10.51.10.70.90.51.01.10.80.70.40.7
Pavlov. Cond. lever latency0.81.13.1-0.7-1.70.2-1.7-0.1-0.1-1.8-0.4-1.5-0.2-0.1-1.8-0.0
Pavlov. Cond. magazine entry latency0.30.30.70.60.80.40.70.5-0.10.60.40.80.40.30.60.4
Pavlov. Cond. change in total contacts1.31.83.11.61.41.31.81.40.80.91.51.71.51.40.51.4
Pavlov. Cond. index score0.50.72.10.31.2-0.21.3-0.0-0.51.40.11.0-0.0-0.21.5-0.1
Pavlov. Cond. latency score0.40.51.30.41.00.01.10.2-0.31.10.21.00.20.01.10.1
Pavlov. Cond. lever contacts0.60.82.80.31.4-0.51.3-0.2-0.31.60.01.1-0.1-0.31.7-0.3
Pavlov. Cond. magazine entry number1.92.35.1-1.6-2.2-0.8-2.3-1.1-0.5-1.8-1.2-2.2-1.1-0.9-1.6-1.0
Pavlov. Cond. intertrial magazine entries1.62.13.5-1.6-1.7-1.3-1.8-1.4-1.3-1.2-1.4-1.9-1.3-1.2-0.9-1.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.90.41.2-0.21.20.0-0.51.30.21.10.1-0.11.4-0.0
Pavlov. Cond. response bias1.01.33.50.91.90.11.80.40.11.70.61.70.40.31.70.3
Conditioned reinforcement - actives1.01.02.80.7-0.41.0-0.80.91.1-1.60.9-0.31.01.1-1.71.0
Conditioned reinforcement - inactives0.30.41.90.0-0.20.0-1.3-0.00.2-1.40.1-0.60.10.1-0.9-0.0
Conditioned locomotion0.91.12.3-1.1-1.5-0.4-1.5-0.7-0.8-1.1-0.9-1.5-0.8-0.7-1.1-0.7
Intermittent access intake day 1-15 change0.70.71.30.90.20.90.10.71.1-0.81.10.41.11.0-0.91.0
Intermittent access intake escalation0.50.51.10.5-0.20.8-0.20.40.8-0.90.8-0.00.80.7-1.10.8
Intermittent access intake escalation 21.01.02.3-0.8-1.4-0.4-1.4-0.8-0.4-1.5-0.4-1.4-0.4-0.4-1.4-0.4
Intermitt. access day 1 inactive lever presses0.30.30.6-0.50.0-0.6-0.7-0.6-0.6-0.2-0.6-0.5-0.7-0.70.2-0.7
Intermitt. access day 15 inactive lever presses2.32.69.31.93.00.51.51.01.61.11.62.31.11.01.60.9
Intermitt. access escalation Index1.41.34.00.61.7-0.21.8-0.10.21.90.21.50.1-0.12.0-0.0
Intermittent access day 1 total infusions1.21.42.2-1.3-1.3-1.1-1.4-1.2-1.1-0.8-1.2-1.5-1.2-1.1-0.6-1.3
Intermittent access day 15 total infusions0.30.30.6-0.5-0.7-0.3-0.7-0.6-0.3-0.7-0.3-0.8-0.4-0.4-0.7-0.4
Intermittent access terminal intake (last 3 days)0.70.81.9-0.7-1.3-0.3-1.3-0.6-0.3-1.4-0.4-1.3-0.4-0.3-1.3-0.5
Intermittent access total infusions1.82.04.2-1.4-2.0-0.6-2.0-1.0-1.0-1.7-1.1-2.0-0.9-0.8-1.6-1.0
Intermittent access day 1 locomotion0.20.20.6-0.3-0.70.0-0.80.0-0.1-0.8-0.2-0.6-0.10.0-0.7-0.1
Intermittent access day 15 total locomotion0.40.41.2-0.5-0.7-0.5-1.1-0.6-0.3-1.0-0.2-0.9-0.4-0.3-0.8-0.5
Intermittent access total locomotion0.50.61.8-0.5-1.1-0.1-1.2-0.3-0.1-1.3-0.2-1.0-0.1-0.1-1.3-0.2
Intermittent access standard deviation0.60.72.70.1-0.80.3-1.10.10.5-1.70.4-0.70.40.4-1.60.3
Cocaine induced anxiety0.10.10.2-0.3-0.3-0.2-0.4-0.3-0.2-0.3-0.1-0.3-0.2-0.2-0.2-0.2
Post-drug Anxiety0.30.40.60.70.40.70.20.70.7-0.20.80.50.70.7-0.20.7
Baseline Anxiety0.40.41.00.60.11.0-0.21.00.6-0.60.50.30.80.8-0.40.7
Lifetime Intake1.21.33.0-1.0-1.7-0.4-1.7-0.7-0.6-1.6-0.8-1.6-0.6-0.5-1.5-0.7
Incentive Sensitization - Responses2.12.15.3-1.3-2.3-0.5-2.1-0.7-0.9-2.0-0.9-2.1-0.6-0.6-1.9-0.6
Incentive Sensitization - Breakpoint2.02.04.5-1.4-2.1-0.8-1.9-1.0-1.1-1.6-1.1-2.0-0.9-0.9-1.5-0.9
Progressive ratio test 1 active lever presses0.91.03.30.4-0.80.8-1.10.60.8-1.80.6-0.60.70.9-1.80.7
Progressive ratio test 1 breakpoint1.11.13.30.6-0.61.0-1.00.81.0-1.80.8-0.40.91.1-1.80.9
Progressive ratio test 1 inactive lever presses0.91.04.00.0-1.00.5-1.60.40.3-2.00.3-1.00.40.5-1.80.4
Progressive ratio test 2 active lever presses2.52.66.9-1.2-2.6-0.2-2.5-0.5-0.8-2.5-0.8-2.3-0.5-0.4-2.5-0.5
Progressive ratio test 2 breakpoint1.92.26.0-1.0-2.3-0.0-2.2-0.3-0.5-2.4-0.5-2.0-0.3-0.2-2.4-0.2
Progressive ratio test 2 inactive lever presses1.72.03.2-1.5-1.1-1.6-1.8-1.6-1.4-1.0-1.3-1.6-1.5-1.4-0.4-1.5
Total sessions with >9 infusions0.50.51.1-0.8-1.0-0.2-1.0-0.4-0.7-0.6-0.8-0.9-0.6-0.5-0.6-0.5
Short access day 1 total inactive lever presses0.10.10.50.20.7-0.40.1-0.20.20.10.20.2-0.0-0.00.4-0.3
Short access day 10 total inactive lever presses0.60.72.4-0.8-1.0-0.4-1.5-0.3-0.7-1.1-0.7-1.2-0.6-0.5-0.8-0.5
Short access day 1 total infusions0.30.41.40.0-0.50.4-1.00.30.3-1.20.2-0.50.20.4-1.10.2
Short access day 10 total infusions0.50.62.2-0.3-0.9-0.2-1.3-0.20.0-1.5-0.0-1.0-0.00.1-1.4-0.2
Short access total infusions0.60.72.1-0.5-1.2-0.0-1.4-0.2-0.1-1.5-0.2-1.1-0.1-0.0-1.4-0.2
Short access day 1 locomotion0.20.20.9-0.2-0.80.2-0.80.1-0.0-0.8-0.1-0.6-0.00.1-0.90.1
Short access day 10 total locomotion1.61.83.01.1-0.21.7-0.81.51.3-1.71.30.11.41.5-1.71.5
Short access total locomotion1.51.55.20.1-1.41.0-1.70.70.5-2.30.4-1.10.60.8-2.30.7
Compulsive drug intake0.30.30.80.2-0.70.60.00.70.3-0.40.4-0.10.60.6-0.90.6
One hour access (0.3 mA shock)1.61.96.6-0.6-2.30.4-1.90.1-0.1-2.3-0.2-1.70.10.2-2.60.1
One hour access (shock baseline)1.71.95.3-1.1-2.0-0.1-2.3-0.6-0.8-2.1-0.9-2.0-0.6-0.5-1.9-0.5
Number of responses in last shaping day2.32.33.51.91.81.31.31.51.80.31.81.81.61.60.31.5
Context. condit. distance diff. score1.31.63.0-1.3-0.2-1.7-0.6-1.6-1.10.4-1.5-0.9-1.6-1.60.9-1.7
Locomotion velocity, session 10.50.61.7-0.50.4-0.80.6-0.70.11.2-0.80.2-0.8-0.81.3-0.8
Locomotion distance, session 10.60.82.80.80.70.71.20.81.70.70.70.90.80.70.40.7
Locomotion velocity, session 20.20.30.50.50.70.30.70.40.60.60.40.70.30.30.50.4
Locomotion distance, session 20.10.21.10.50.7-0.00.40.01.00.10.50.50.30.20.20.2
Locomotion velocity, session 30.60.61.7-0.50.6-1.30.2-1.0-0.00.7-0.70.0-0.8-0.91.1-1.1
Locomotion distance, session 32.83.05.6-1.9-0.8-2.4-0.8-2.3-2.00.3-2.0-1.3-2.0-2.00.8-2.2
Stereotopy head waving bouts, day 30.60.71.50.90.21.2-0.11.11.0-0.60.90.41.01.0-0.71.1
Stereotopy head waving duration, day 30.10.20.40.40.30.7-0.00.60.6-0.20.40.30.40.4-0.10.5
Locomotion velocity, session 71.71.94.11.62.00.81.61.11.61.01.31.91.21.11.11.0
Locomotion distance, session 70.40.51.1-0.7-0.1-1.1-0.3-1.1-0.70.1-0.7-0.4-0.8-0.90.4-0.9
Stereotopy head waving bouts, day 70.70.71.80.81.30.31.20.60.51.10.51.20.50.51.10.4
Stereotopy head waving duration, day 70.91.11.91.30.91.30.71.41.10.11.21.11.21.3-0.01.2
Locomotion velocity, session 80.91.02.21.31.50.70.81.01.30.31.11.31.01.00.50.9
Locomotion distance, session 81.01.53.2-1.20.1-1.8-0.3-1.7-0.80.6-1.4-0.6-1.5-1.61.1-1.6
Degree of sensitization distance1.31.32.21.30.51.50.31.41.3-0.61.40.81.41.4-0.71.4
Degree of sensitization stereotypy0.40.41.20.51.10.01.00.30.31.00.30.90.30.21.00.2
Condit. Reinf. active minus inactive responses4.34.810.62.43.31.22.61.72.71.82.03.01.71.61.81.6
Condit. Reinf. active-inactive response ratio3.33.67.12.12.71.32.11.72.41.41.82.51.61.51.41.5
Condit. Reinf. active responses5.97.217.32.94.21.23.31.83.12.42.53.72.01.92.41.8
Condit. Reinf. inactive responses2.83.310.71.63.3-0.12.60.31.32.31.32.60.70.62.50.5
Incentive salience index mean5.46.513.42.73.71.33.41.93.02.52.23.51.91.82.31.7
Condit. Reinf. lever presses6.08.114.83.13.71.73.82.33.22.72.73.82.32.22.22.2
Time in familiar zone, hab. session 10.40.30.70.60.80.50.80.50.10.60.50.80.50.40.60.5
Time in novel zone, hab. session 10.20.20.5-0.2-0.6-0.0-0.5-0.00.5-0.6-0.0-0.50.00.1-0.70.0
Total zone transitions, hab. session 10.50.72.70.71.00.11.30.31.71.10.51.00.40.40.80.3
Total locomotion distance, hab. session 11.01.54.00.91.60.22.00.51.61.80.61.60.50.41.50.4
Locomotion velocity, hab. session 10.91.33.40.91.50.21.90.51.61.70.61.50.50.41.40.4
Time in familiar zone, hab. session 20.20.20.9-0.1-0.60.4-0.60.2-0.9-0.7-0.1-0.30.10.1-0.50.1
Time in novel zone, hab. session 20.80.82.80.81.5-0.11.20.21.71.00.71.10.40.31.00.3
Total zone transitions, hab. session 20.30.42.00.70.70.40.60.41.40.10.70.60.60.60.00.6
Total locomotion distance, hab. session 20.60.82.71.01.30.31.00.51.70.60.81.10.70.60.70.5
Locomotion velocity, hab. session 20.30.52.20.71.00.20.70.31.50.40.60.80.40.40.50.4
Novel to familiar place preference ratio1.11.12.5-1.0-1.6-0.4-1.6-0.6-1.1-1.3-0.7-1.5-0.6-0.6-1.3-0.5
Novelty place preference1.31.32.2-1.3-1.4-0.9-1.4-1.1-1.4-0.8-1.1-1.5-1.1-1.0-0.7-1.0
Time in novel zone, NPP test1.41.42.1-1.4-1.3-1.1-1.3-1.2-1.4-0.7-1.3-1.5-1.2-1.2-0.5-1.2
Total zone transitions, NPP test0.10.10.9-0.00.1-0.30.3-0.20.90.20.00.0-0.0-0.00.1-0.1
Total locomotion distance, NPP test0.60.92.50.11.2-0.81.3-0.50.81.6-0.20.9-0.3-0.41.6-0.5
Locomotion velocity, NPP test0.50.82.10.51.3-0.31.5-0.11.01.40.31.10.10.01.3-0.0
Pavlov. Cond. lever latency2.32.96.1-1.9-2.5-0.8-2.3-1.1-2.2-1.5-1.7-2.2-1.4-1.3-1.3-1.2
Pavlov. Cond. magazine entry latency6.58.412.23.52.72.92.43.23.50.43.53.03.33.3-0.03.3
Pavlov. Cond. change in total contacts4.04.27.72.32.71.12.81.52.31.72.12.71.81.71.31.6
Pavlov. Cond. index score4.55.88.72.92.42.32.02.53.00.32.92.62.72.70.02.6
Pavlov. Cond. latency score3.24.06.92.42.11.81.82.02.60.42.42.22.22.20.12.1
Pavlov. Cond. lever contacts3.03.66.42.12.51.12.41.52.31.51.92.41.61.61.21.5
Pavlov. Cond. magazine entry number3.94.87.4-2.7-2.0-2.2-1.7-2.4-2.6-0.1-2.7-2.2-2.6-2.50.2-2.5
Pavlov. Cond. intertrial magazine entries2.22.67.4-0.71.6-2.01.3-1.7-0.82.3-1.10.7-1.4-1.52.7-1.7
Pavlov. Cond. lever-magazine prob. diff.5.46.810.13.22.52.52.32.73.10.53.22.83.02.90.12.9
Pavlov. Cond. response bias5.77.010.93.13.32.02.92.43.21.43.03.32.62.51.12.5
Bone: apparent density1.11.83.41.51.80.91.61.21.41.01.31.81.21.11.01.1
Bone surface3.05.39.02.63.01.62.72.22.71.72.33.02.12.01.52.0
Bone volume1.93.36.52.02.51.12.31.52.11.61.72.41.51.41.51.4
Bone: connectivity density3.25.07.52.72.12.21.92.52.70.52.62.42.52.40.12.4
Bone: cortical apparent density1.31.72.71.61.41.31.21.41.10.21.61.51.51.40.11.5
Bone: cortical area0.30.51.1-0.60.3-1.1-0.0-0.90.30.6-0.7-0.2-0.9-0.90.8-0.9
Bone: cortical porosity0.30.30.7-0.40.2-0.70.3-0.5-0.40.8-0.6-0.0-0.6-0.60.8-0.6
Bone: cortical porosity0.20.20.8-0.00.6-0.40.5-0.20.20.8-0.20.4-0.2-0.30.9-0.3
Bone: cortical thickness1.32.13.8-1.5-0.1-1.9-0.1-1.8-0.81.2-1.8-0.7-1.8-1.91.4-1.9
Bone: cortical thickness2.02.44.2-1.8-0.9-1.9-1.0-2.0-1.00.0-1.8-1.5-1.9-1.90.4-1.9
Bone: cortical tissue density1.31.72.61.61.31.41.11.41.10.21.61.51.51.40.11.5
Bone: elastic displacement5.15.79.7-2.7-1.2-2.8-0.0-2.5-2.52.0-3.1-1.4-2.9-3.01.9-2.9
Bone: elastic work2.43.15.4-2.0-0.7-2.3-0.1-2.0-1.11.5-2.3-1.0-2.2-2.31.5-2.3
Bone: endosteal estimation0.51.12.31.10.31.3-0.11.31.5-0.81.20.51.21.3-0.91.3
Bone: endosteal perimeter0.20.31.00.1-0.50.5-0.70.50.7-1.00.3-0.40.40.5-1.00.4
Bone: final force1.01.73.71.51.21.40.81.61.90.11.41.31.41.4-0.01.4
Bone: final moment0.91.63.61.41.21.30.81.51.90.21.31.31.31.30.11.3
Bone: marrow area0.51.02.21.00.21.2-0.21.21.5-0.91.10.31.11.2-0.91.2
Bone: maximum diameter0.10.22.60.10.2-0.1-0.40.01.6-0.50.2-0.20.10.1-0.30.1
Bone: maximum force0.30.61.60.90.60.80.10.91.3-0.30.80.60.80.9-0.30.9
Bone: maximum moment0.30.51.60.80.60.70.20.91.2-0.10.70.60.70.8-0.10.7
Bone: minimum diameter0.10.20.90.50.30.4-0.10.51.0-0.30.50.30.50.6-0.30.5
Bone: periosteal estimation0.10.11.10.20.20.1-0.30.31.1-0.30.2-0.00.20.3-0.20.2
Bone: periosteal perimeter0.10.10.8-0.0-0.2-0.0-0.60.00.9-0.60.0-0.30.00.1-0.40.0
Bone: post-yield work1.11.53.21.40.71.20.21.31.8-0.81.60.81.51.5-0.81.4
Bone: stiffness1.01.52.51.30.31.5-0.41.41.2-1.31.50.51.51.6-1.21.5
Bone: tissue strength0.00.00.1-0.2-0.3-0.1-0.10.0-0.20.1-0.2-0.2-0.1-0.1-0.0-0.1
Bone: trabecular number1.32.13.51.61.71.21.81.41.41.21.41.91.31.21.01.3
Bone: trabecular spacing3.03.96.1-2.3-2.0-2.1-2.1-2.3-1.4-1.2-2.0-2.5-2.1-2.0-0.8-2.1
Bone: trabecular thickness0.30.40.70.70.50.70.40.80.70.00.60.60.70.7-0.00.7
Bone: trabecular tissue density1.01.42.81.20.21.70.11.60.6-0.91.40.61.51.6-1.01.6
Breakpoint value in progressive ratio session1.21.42.21.1-0.01.2-0.21.01.5-1.31.50.21.31.4-1.51.4
Distance traveled before self-admin0.30.30.6-0.40.2-0.80.4-0.7-0.30.8-0.60.0-0.5-0.60.8-0.5
Distance traveled after self-admin0.10.10.40.20.50.10.50.10.20.50.00.40.10.10.60.2
Delta time in closed arm before/after self-admin0.00.00.10.10.1-0.10.1-0.10.1-0.20.20.00.20.1-0.20.0
Delta time in open arm before/after self-admin0.30.30.5-0.50.1-0.60.2-0.6-0.40.7-0.5-0.1-0.7-0.70.6-0.5
Diff in mean of infusions in LGA sessions0.50.61.20.80.30.60.10.61.1-0.71.10.30.81.0-0.80.8
Extinction: sum of active levers before priming4.64.611.8-2.2-3.4-0.6-3.0-1.4-1.6-2.4-1.6-3.1-1.5-1.3-2.5-1.2
Active lever presses in extinction session 61.31.34.30.3-1.11.0-1.20.60.9-2.00.7-0.80.80.9-2.10.8
Delta distance traveled before/after self-admin0.20.20.40.50.50.60.20.60.50.10.60.50.50.50.10.4
Delta ambulatory time before/after self-admin0.30.30.60.70.50.80.10.80.7-0.10.70.50.60.7-0.10.6
Time in closed arm before self-admin0.30.40.80.2-0.70.9-0.40.80.3-0.80.4-0.20.60.6-0.90.6
Time in closed arm after self-admin1.21.34.50.1-1.51.2-1.10.70.4-1.80.5-0.80.80.9-2.10.8
Time in open arm before self-admin0.70.72.50.71.60.21.10.20.51.10.41.20.30.21.30.2
Time in open arm after self-admin0.40.40.7-0.7-0.1-0.7-0.3-0.7-0.80.4-0.7-0.4-0.9-0.80.5-0.7
Sum of active levers in priming session hrs 5-61.00.93.10.4-0.90.9-0.70.80.8-1.50.8-0.50.91.0-1.80.9
Time to tail flick, vehicle, before self-admin0.10.10.7-0.2-0.2-0.2-0.8-0.1-0.1-0.70.0-0.5-0.2-0.1-0.5-0.2
Time to tail flick, vehicle, after self-admin4.34.614.4-1.3-3.00.2-3.8-0.2-0.8-3.7-1.0-2.8-0.5-0.2-3.2-0.2
Time to tail flick, test, before self-admin0.70.72.0-0.5-1.30.3-1.40.2-0.4-1.4-0.2-1.1-0.10.1-1.4-0.0
Time to tail flick, test, after self-admin0.40.41.2-0.1-0.80.6-0.90.4-0.1-1.1-0.0-0.60.20.3-1.00.3
Delta time to tail flick, vehicle, before/after SA0.20.20.7-0.5-0.6-0.2-0.8-0.3-0.4-0.6-0.6-0.6-0.3-0.3-0.3-0.2
Delta time to tail flick, test, before/after SA0.40.31.1-0.20.7-0.70.2-0.5-0.40.7-0.50.2-0.5-0.61.1-0.5
Ambulatory time before self-admin1.01.01.9-1.0-0.0-1.30.3-1.4-1.01.0-1.2-0.3-1.2-1.21.1-1.1
Ambulatory time after self-admin0.10.10.2-0.4-0.5-0.1-0.3-0.3-0.2-0.1-0.4-0.5-0.3-0.3-0.1-0.2
Total heroin consumption0.60.71.41.00.50.90.40.81.2-0.41.00.61.01.1-0.41.1
Area under the delay curve1.41.45.30.4-1.20.9-1.20.70.9-2.10.9-0.80.91.1-2.30.9
Delay disc. indifference point, 0s delay2.52.77.1-1.6-2.7-0.7-2.4-0.8-1.3-2.0-1.4-2.3-0.9-0.8-1.9-0.9
Delay disc. indifference point, 16s delay4.64.67.61.9-0.32.6-0.72.32.4-2.52.40.32.42.6-2.82.5
Delay disc. indifference point, 2s delay1.01.24.1-0.5-1.90.4-1.40.4-0.2-1.7-0.2-1.30.10.3-2.00.2
Delay disc. indifference point, 24s delay3.63.55.41.7-0.12.0-0.41.92.2-2.02.30.32.22.3-2.32.2
Delay disc. indifference point, 4s delay3.33.58.7-1.4-2.9-0.2-3.0-0.5-0.9-2.9-0.8-2.6-0.6-0.4-2.8-0.5
Delay disc. indifference point, 8s delay0.50.62.3-0.2-1.20.1-0.9-0.00.2-1.30.1-0.90.20.3-1.50.1
Delay discount exponential model param1.21.35.0-0.21.2-0.71.2-0.6-0.72.0-0.80.9-0.7-0.92.2-0.7
Delay discount hyperbolic model param1.21.35.2-0.01.4-0.61.4-0.5-0.52.1-0.61.0-0.6-0.72.3-0.6
Fecal boli incidents, locomotor time 10.10.10.2-0.10.1-0.4-0.5-0.2-0.1-0.3-0.1-0.2-0.3-0.1-0.1-0.3
Change in fecal boli incidents, locomotor task1.41.35.6-1.0-2.40.7-1.40.1-0.7-1.3-0.7-1.6-0.3-0.2-1.8-0.0
Time >=10cm from walls, locomotor time 11.71.85.7-0.6-2.00.3-2.20.2-0.3-2.4-0.3-1.60.10.2-2.20.2
Bouts of movement, locomotor time 10.20.20.50.60.60.1-0.20.20.7-0.60.70.30.50.5-0.30.4
Total resting periods, locomotor time 10.20.20.60.50.40.1-0.40.20.7-0.80.70.10.40.6-0.50.4
Rest time, locomotor task time 10.00.00.1-0.10.3-0.3-0.2-0.3-0.0-0.0-0.1-0.0-0.3-0.10.2-0.3
Distance moved, locomotor task time 12.32.56.8-1.5-2.6-0.6-2.2-0.6-1.1-1.9-1.2-2.3-0.8-0.7-2.1-0.8
Vertical activity count, locomotor time 11.41.54.20.2-1.61.6-1.11.30.4-1.70.5-0.81.00.9-2.11.2
Time >=10cm from walls, locomotor time 22.22.34.8-1.6-2.1-1.0-2.2-1.0-1.5-1.6-1.4-2.1-1.1-1.1-1.3-1.1
Bouts of movement, locomotor time 20.50.51.00.70.00.90.31.00.9-0.20.80.30.80.8-0.50.9
Total resting periods, locomotor time 20.30.40.70.5-0.20.80.10.80.8-0.30.60.20.70.7-0.60.7
Rest time, locomotor task time 20.80.91.41.01.20.81.20.71.10.71.01.20.80.80.50.8
Distance moved, locomotor task time 21.21.43.0-1.2-1.6-1.1-1.7-0.7-1.0-1.4-1.1-1.7-0.8-0.8-1.1-0.9
Vertical activity count, locomotor time 21.21.34.10.1-1.31.0-1.51.00.3-2.00.4-1.00.80.7-1.90.9
Weight adjusted by age1.21.31.91.30.91.21.41.11.30.61.31.31.11.20.11.2
Seeking ratio, delayed vs. immediate footshock1.82.13.5-1.8-1.9-1.4-1.2-1.1-1.9-0.3-1.9-1.7-1.5-1.4-0.3-1.4
Locomotion in novel chamber0.10.10.40.20.5-0.00.40.0-0.00.50.10.50.0-0.10.60.0
Locomotion in novel chamber post-restriction0.00.00.2-0.1-0.40.4-0.10.3-0.1-0.0-0.2-0.10.00.0-0.20.1
Progressive ratio0.60.72.0-0.01.1-1.11.0-0.8-0.21.3-0.10.6-0.5-0.61.4-0.7
Food seeking constrained by brief footshock0.30.40.8-0.50.0-0.9-0.9-0.8-0.7-0.5-0.6-0.6-0.6-0.70.2-0.8
Seeking ratio, punishment vs. effort0.60.72.6-0.4-1.10.3-1.60.1-0.2-1.6-0.3-1.1-0.10.0-1.30.1
Run reversals in cocaine runway, females0.10.10.40.2-0.30.7-0.10.40.3-0.30.2-0.00.30.3-0.50.4
Run reversals in cocaine runway, males3.33.210.40.92.5-0.33.1-0.00.33.20.42.20.2-0.13.00.0
Latency to leave start box in cocaine runway2.02.24.3-1.6-1.8-1.4-1.9-1.3-1.3-1.3-1.4-2.1-1.3-1.1-1.1-1.3
Latency to leave start box in cocaine runway, F1.01.12.1-1.1-1.1-1.2-1.4-0.9-0.8-0.9-1.0-1.5-1.0-0.8-0.6-1.0
Latency to leave start box in cocaine runway, M0.80.81.2-1.1-0.8-1.1-0.6-1.1-1.1-0.1-1.0-0.9-1.1-1.00.0-1.0
Cd content in liver1.41.62.5-1.5-0.8-1.6-0.7-1.5-1.40.2-1.5-1.1-1.5-1.50.5-1.5
Co content in liver1.72.03.3-1.6-0.7-1.6-0.6-1.7-1.80.6-1.7-1.0-1.7-1.70.8-1.7
Cu content in liver0.91.02.61.20.80.90.30.91.6-0.61.40.71.21.2-0.61.1
Fe content in liver0.30.31.30.20.50.11.10.00.51.10.00.60.0-0.10.80.0
K content in liver0.30.30.60.5-0.20.8-0.00.60.2-0.50.60.10.60.7-0.70.7
Mg content in liver0.20.20.5-0.1-0.70.4-0.40.2-0.3-0.60.1-0.40.10.2-0.70.3
Mn content in liver1.11.32.8-1.4-1.7-0.8-1.2-1.0-0.9-0.7-1.2-1.5-1.0-1.0-0.7-1.0
Na content in liver0.40.41.10.60.40.61.10.61.10.70.50.70.60.50.30.6
Rb content in liver2.12.79.2-0.4-2.20.7-2.60.40.2-3.00.0-1.90.30.5-3.00.4
Se content in liver1.01.33.9-0.40.9-1.21.4-1.0-0.12.0-0.70.6-0.9-1.02.0-1.0
Sr content in liver0.00.00.3-0.1-0.1-0.20.0-0.0-0.50.2-0.20.0-0.1-0.10.1-0.2
Zn content in liver0.40.41.2-0.6-0.4-0.7-0.7-0.8-1.1-0.5-0.5-0.6-0.6-0.6-0.2-0.6