Hub : Genes

Slc1a2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000005479	0.04	0.04	5.6e-05	0.03	0.03	0.03	0.03	1.1e-04	9.7e-05	1.3e-04	1.3e-04
2	NAcc	gene expression	ENSRNOG00000005479	0.05	0.05	1.9e-03	0.04	0.03	0.03	0.04	8.0e-04	1.3e-03	5.4e-03	9.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
BMI with tail	0.1	0.5	0.5	-0.7	0.7
BMI without tail	0.5	1.1	1.1	-1.1	1.1
Body weight	0.3	1.4	1.7	-1.3	1.1
Epididymis fat weight	0.8	1.8	2.0	-1.3	1.4
Glucose	2.3	3.5	3.5	-1.9	1.9
Heart weight	0.5	0.7	0.8	0.9	-0.8
Left kidney weight	0.4	1.2	1.5	-1.2	1.0
Right kidney weight	0.5	1.4	1.6	-1.3	1.1
Tail length	0.3	0.9	1.0	-1.0	0.9
Length with tail	0.1	0.4	0.5	-0.7	0.4
Length without tail	0.0	0.1	0.1	-0.3	0.1
Liver weight, left	0.2	0.4	0.5	-0.5	0.7
Liver weight, right	0.8	1.3	1.5	-1.2	1.1
Parametrial fat weight	1.3	2.5	2.9	-1.5	1.7
Retroperitoneal fat weight	8.2	27.3	27.3	-5.2	5.2
Intraocular pressure	0.1	0.1	0.1	-0.2	0.3
Extensor digitorum longus weight	0.4	1.6	1.6	1.3	-1.3
Soleus weight	1.6	4.6	4.7	2.1	-2.2
Tibialis anterior weight	3.3	11.5	11.5	3.4	-3.4
Tibia length	0.2	0.6	0.7	0.8	-0.6
Number of licking bursts	0.0	0.0	0.1	-0.2	-0.0
Food consumed during 24 hour testing period	6.8	8.1	8.2	-2.8	2.9
Times rat made contact with spout	0.1	0.2	0.2	-0.3	0.4
Mean time between licks in bursts	1.2	1.7	2.0	1.2	-1.4
Mean num. licks in bursts	0.1	0.2	0.3	-0.2	0.5
Std. dev. time between licks in bursts	0.8	0.9	1.0	0.9	-1.0
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	0.1
Indifference point 0 sec	0.1	0.2	0.2	0.4	-0.5
Indifference point AUC	0.6	0.8	1.2	1.1	-0.5
Indifference point function ln k	0.2	0.2	0.4	-0.6	0.3
Indifference point function log k	0.2	0.2	0.4	-0.6	0.3
Delay discounting total patch changes 0 sec	0.1	0.1	0.1	0.3	-0.3
Delay discounting total patch changes 12 sec	0.5	0.6	0.9	-0.6	0.9
Delay discounting total patch changes 18 sec	0.2	0.2	0.4	0.6	-0.3
Delay discounting total patch changes 24 sec	0.6	0.7	0.9	1.0	-0.7
Delay discounting total patch changes 6 sec	0.0	0.0	0.1	0.3	0.2
Delay discounting time to switch 0 sec	0.0	0.0	0.1	-0.3	0.1
Delay discounting water rate 0 sec	0.1	0.1	0.1	0.3	-0.3
Delay discounting water rate 12 sec	0.5	0.8	0.9	0.9	-0.9
Delay discounting water rate 18 sec	0.3	0.4	0.5	-0.7	0.6
Delay discounting water rate 24 sec	0.5	0.7	0.8	0.9	-0.8
Delay discounting water rate 6 sec	0.2	0.3	0.5	0.4	-0.7
Locomotor activity	0.0	0.0	0.0	-0.2	0.2
Locomotor testing distance	1.1	1.8	1.9	-1.4	1.3
Locomotor testing rearing	0.1	0.1	0.2	-0.5	0.3
Light reinforcement 1	0.3	0.5	0.7	-0.6	0.8
Light reinforcement 2	0.0	0.0	0.0	-0.0	-0.1
Reaction time number correct	0.1	0.1	0.2	0.0	0.5
Reaction time mean minus median	0.9	1.1	1.4	-0.9	1.2
Reaction time mean minus median AUC	0.5	0.7	0.9	-0.7	0.9
Reaction time num false alarms	1.4	2.0	2.1	1.4	-1.5
Reaction time num false alarms AUC	2.3	3.3	3.4	1.8	-1.8
Reaction time trials correct on left	0.1	0.1	0.2	0.0	0.5
Reaction time trials on left	0.0	0.1	0.1	0.1	0.4
Reaction time mean	0.2	0.2	0.3	-0.6	0.4
Reaction time mean AUC	0.2	0.3	0.4	-0.6	0.4
Median of all reaction times	0.2	0.3	0.5	-0.7	0.4
Reaction time omissions	0.6	0.8	0.9	0.9	-0.9
Reaction time false alarm rate	2.9	4.2	4.7	1.9	-2.2
Reaction time premature initiation rate	0.1	0.1	0.2	0.4	-0.1
Reaction time premature initiations	0.1	0.1	0.1	0.3	0.2
Std. dev. reaction times	0.0	0.1	0.1	-0.2	0.3
Reaction time trials completed	0.0	0.1	0.1	0.1	0.4
Reaction time trials AUC	0.1	0.2	0.4	-0.1	0.6
Social response proportion	4.5	4.9	4.9	2.2	-2.2
Social responses	0.1	0.1	0.1	-0.4	0.3
Social time	1.3	1.7	2.4	1.6	-1.0
Conditioned locomotion	5.1	6.0	6.7	2.3	-2.6
Cocaine response after cond. corrected	2.0	2.3	2.4	1.5	-1.5
Cocaine response after cond. not corrected	0.5	0.6	0.6	0.8	-0.8
Cocaine response before conditioning	3.8	4.6	5.1	-2.3	2.0
Saline control response	0.8	1.1	1.1	-1.0	1.1
Condit. Reinf. active minus inactive responses	1.2	1.5	1.7	-1.3	1.2
Condit. Reinf. active-inactive response ratio	3.0	3.2	3.4	-1.8	1.7
Condit. Reinf. active responses	0.8	1.1	1.2	-1.1	1.0
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.1	-0.2
Condit. Reinf. lever presses	0.6	0.8	0.9	-0.9	0.9
Condit. Reinf. lever reinforcers received	0.9	1.3	1.4	-1.2	1.1
Pavlov. Cond. lever latency	2.7	3.7	3.8	1.9	-2.0
Pavlov. Cond. magazine entry latency	1.2	1.4	1.4	-1.2	1.2
Pavlov. Cond. change in total contacts	1.1	1.5	1.6	-1.2	1.3
Pavlov. Cond. index score	2.2	2.9	2.9	-1.7	1.7
Pavlov. Cond. latency score	2.8	3.5	3.6	-1.8	1.9
Pavlov. Cond. lever contacts	2.6	3.7	3.8	-1.9	2.0
Pavlov. Cond. magazine entry number	0.7	0.9	0.9	0.9	-1.0
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.3	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	2.3	-1.5	1.5
Pavlov. Cond. response bias	2.1	2.9	3.0	-1.7	1.7
Conditioned reinforcement - actives	3.6	3.6	3.6	-1.9	1.9
Conditioned reinforcement - inactives	9.2	10.4	11.3	-3.1	3.4
Conditioned locomotion	2.7	3.3	3.3	-1.8	1.8
Intermittent access intake day 1-15 change	0.1	0.1	0.1	-0.2	0.3
Intermittent access intake escalation	0.3	0.3	0.3	-0.5	0.6
Intermittent access intake escalation 2	1.9	1.9	1.9	-1.4	1.4
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	0.3	-0.4
Intermitt. access day 15 inactive lever presses	2.9	3.2	3.6	-1.7	1.9
Intermitt. access escalation Index	0.0	0.0	0.0	-0.2	-0.0
Intermittent access day 1 total infusions	3.5	4.0	4.6	-2.2	1.8
Intermittent access day 15 total infusions	4.4	5.0	5.3	-2.3	2.1
Intermittent access terminal intake (last 3 days)	5.5	6.1	6.5	-2.5	2.4
Intermittent access total infusions	5.1	5.6	6.3	-2.5	2.2
Intermittent access day 1 locomotion	1.4	1.4	1.9	-1.4	1.0
Intermittent access day 15 total locomotion	2.6	2.7	3.1	-1.7	1.6
Intermittent access total locomotion	2.4	2.7	3.1	-1.8	1.5
Intermittent access standard deviation	6.0	6.4	6.4	-2.5	2.5
Cocaine induced anxiety	0.1	0.1	0.1	-0.3	0.3
Post-drug Anxiety	0.0	0.0	0.0	0.2	0.2
Baseline Anxiety	2.1	2.2	2.6	1.6	-1.4
Lifetime Intake	5.3	5.9	6.6	-2.6	2.3
Incentive Sensitization - Responses	1.6	1.6	1.8	-1.1	1.4
Incentive Sensitization - Breakpoint	1.4	1.4	1.6	-1.1	1.3
Progressive ratio test 1 active lever presses	3.6	3.8	4.0	-2.0	1.9
Progressive ratio test 1 breakpoint	3.3	3.4	3.5	-1.9	1.8
Progressive ratio test 1 inactive lever presses	2.3	2.4	2.5	-1.6	1.5
Progressive ratio test 2 active lever presses	2.7	2.9	3.0	-1.7	1.7
Progressive ratio test 2 breakpoint	3.2	3.6	3.6	-1.9	1.9
Progressive ratio test 2 inactive lever presses	3.2	3.6	3.7	-1.9	1.9
Total sessions with >9 infusions	1.5	1.6	1.9	-1.4	1.2
Short access day 1 total inactive lever presses	0.8	0.9	0.9	-1.0	0.9
Short access day 10 total inactive lever presses	0.2	0.3	0.4	-0.4	0.6
Short access day 1 total infusions	6.4	6.8	7.3	-2.7	2.5
Short access day 10 total infusions	2.9	3.2	3.5	-1.9	1.7
Short access total infusions	3.8	4.2	4.7	-2.2	1.9
Short access day 1 locomotion	2.4	2.5	3.2	-1.8	1.4
Short access day 10 total locomotion	3.7	4.0	4.3	-2.1	1.9
Short access total locomotion	2.6	2.7	3.3	-1.8	1.4
Compulsive drug intake	0.9	0.9	1.1	1.0	-0.9
One hour access (0.3 mA shock)	4.2	4.9	4.9	-2.2	2.2
One hour access (shock baseline)	6.1	7.0	7.0	-2.7	2.6
Number of responses in last shaping day	0.8	0.8	0.9	-0.9	0.9
Context. condit. distance diff. score	1.9	2.3	2.9	-1.7	1.3
Locomotion velocity, session 1	0.0	0.0	0.0	-0.0	0.1
Locomotion distance, session 1	0.1	0.2	0.2	-0.4	0.4
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	-0.1
Locomotion distance, session 2	0.4	0.5	0.6	-0.8	0.7
Locomotion velocity, session 3	0.3	0.3	0.4	-0.5	0.6
Locomotion distance, session 3	0.3	0.3	0.3	-0.6	0.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	-0.2	0.3
Stereotopy head waving duration, day 3	0.5	0.6	0.7	-0.8	0.8
Locomotion velocity, session 7	0.4	0.4	0.5	-0.5	0.7
Locomotion distance, session 7	0.2	0.2	0.3	0.5	-0.5
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.1	0.0
Stereotopy head waving duration, day 7	0.0	0.0	0.0	0.0	-0.0
Locomotion velocity, session 8	0.8	0.9	1.1	-1.0	0.9
Locomotion distance, session 8	2.8	4.2	5.0	-2.2	1.8
Degree of sensitization distance	0.6	0.6	0.7	0.7	-0.8
Degree of sensitization stereotypy	0.0	0.0	0.1	0.2	-0.2
Condit. Reinf. active minus inactive responses	0.9	1.1	1.1	-1.0	1.1
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.5	-1.2	1.2
Condit. Reinf. active responses	0.3	0.3	0.4	-0.5	0.6
Condit. Reinf. inactive responses	0.3	0.3	0.4	0.5	-0.6
Incentive salience index mean	0.8	1.0	1.1	-1.0	1.0
Condit. Reinf. lever presses	0.7	0.9	1.0	-0.9	1.0
Time in familiar zone, hab. session 1	0.4	0.4	0.4	0.6	-0.6
Time in novel zone, hab. session 1	0.6	0.5	0.6	-0.8	0.7
Total zone transitions, hab. session 1	2.6	3.7	3.9	-2.0	1.9
Total locomotion distance, hab. session 1	1.0	1.5	1.7	-1.3	1.1
Locomotion velocity, hab. session 1	0.7	1.1	1.2	-1.1	1.0
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.1	0.2
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.1	-0.1
Total zone transitions, hab. session 2	2.3	2.9	2.9	-1.7	1.7
Total locomotion distance, hab. session 2	0.1	0.1	0.1	-0.3	0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.3	0.1
Novel to familiar place preference ratio	1.1	1.2	1.2	-1.0	1.1
Novelty place preference	1.0	1.0	1.1	-1.0	1.0
Time in novel zone, NPP test	0.7	0.7	0.8	-0.8	0.9
Total zone transitions, NPP test	0.3	0.4	0.4	0.7	-0.6
Total locomotion distance, NPP test	0.3	0.4	0.4	0.5	-0.6
Locomotion velocity, NPP test	0.1	0.2	0.3	0.4	-0.5
Pavlov. Cond. lever latency	0.7	0.9	1.0	0.9	-1.0
Pavlov. Cond. magazine entry latency	1.4	1.8	1.8	-1.3	1.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	-0.4
Pavlov. Cond. index score	0.6	0.8	0.9	-0.8	0.9
Pavlov. Cond. latency score	0.7	0.9	1.0	-0.9	1.0
Pavlov. Cond. lever contacts	0.3	0.4	0.4	-0.6	0.6
Pavlov. Cond. magazine entry number	1.4	1.8	1.9	1.3	-1.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.7	-0.7	0.9
Pavlov. Cond. response bias	1.1	1.3	1.3	-1.1	1.2
Bone: apparent density	0.7	1.1	1.2	-1.1	1.1
Bone surface	0.3	0.6	0.7	-0.8	0.8
Bone volume	1.6	2.6	2.6	-1.6	1.6
Bone: connectivity density	0.4	0.7	0.7	-0.8	0.8
Bone: cortical apparent density	0.1	0.1	0.2	0.3	-0.4
Bone: cortical area	0.0	0.0	0.0	0.0	0.0
Bone: cortical porosity	0.5	0.6	0.6	0.7	-0.8
Bone: cortical porosity	0.4	0.5	0.5	0.6	-0.7
Bone: cortical thickness	0.0	0.1	0.1	0.3	-0.2
Bone: cortical thickness	5.3	6.2	6.3	2.5	-2.5
Bone: cortical tissue density	0.1	0.1	0.1	0.2	-0.4
Bone: elastic displacement	1.7	1.9	2.3	1.5	-1.2
Bone: elastic work	1.3	1.7	2.2	1.5	-1.1
Bone: endosteal estimation	0.4	0.9	1.1	0.8	-1.0
Bone: endosteal perimeter	0.1	0.3	0.4	-0.6	0.4
Bone: final force	0.0	0.0	0.0	0.2	-0.1
Bone: final moment	0.1	0.2	0.2	0.5	-0.4
Bone: marrow area	0.4	0.8	1.0	0.8	-1.0
Bone: maximum diameter	0.0	0.0	0.0	-0.2	0.1
Bone: maximum force	0.0	0.0	0.0	-0.1	0.0
Bone: maximum moment	0.1	0.1	0.1	0.4	-0.3
Bone: minimum diameter	0.2	0.3	0.3	-0.6	0.5
Bone: periosteal estimation	0.2	0.4	0.5	0.6	-0.7
Bone: periosteal perimeter	0.8	1.3	1.3	-1.2	1.1
Bone: post-yield work	0.0	0.1	0.1	0.1	-0.3
Bone: stiffness	0.2	0.3	0.5	-0.7	0.4
Bone: tissue strength	0.0	0.0	0.0	0.0	0.0
Bone: trabecular number	0.3	0.5	0.6	-0.8	0.7
Bone: trabecular spacing	0.5	0.6	0.8	-0.7	0.9
Bone: trabecular thickness	0.1	0.2	0.2	-0.4	0.4
Bone: trabecular tissue density	1.1	1.6	1.7	1.2	-1.3
Breakpoint value in progressive ratio session	1.1	1.3	1.4	1.2	-1.1
Distance traveled before self-admin	0.3	0.4	0.5	-0.7	0.5
Distance traveled after self-admin	0.5	0.6	0.8	-0.6	0.9
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.2	-0.0
Delta time in open arm before/after self-admin	1.0	0.9	1.2	0.8	-1.1
Diff in mean of infusions in LGA sessions	0.5	0.5	0.6	0.8	-0.7
Extinction: sum of active levers before priming	0.5	0.5	0.6	-0.8	0.7
Active lever presses in extinction session 6	0.7	0.6	0.8	-0.9	0.7
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.4	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.4	-0.3
Time in closed arm before self-admin	0.6	0.7	0.7	-0.8	0.8
Time in closed arm after self-admin	0.4	0.4	0.4	-0.6	0.7
Time in open arm before self-admin	0.6	0.6	0.8	0.7	-0.9
Time in open arm after self-admin	1.6	1.8	1.9	1.3	-1.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.4	0.6	-0.6
Time to tail flick, vehicle, before self-admin	5.0	5.0	5.2	-2.2	2.3
Time to tail flick, vehicle, after self-admin	5.2	5.5	5.8	-2.3	2.4
Time to tail flick, test, before self-admin	0.7	0.7	0.8	-0.8	0.9
Time to tail flick, test, after self-admin	2.3	2.3	2.9	-1.3	1.7
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.0	0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	-0.4	0.4
Ambulatory time before self-admin	0.1	0.1	0.2	-0.4	0.3
Ambulatory time after self-admin	0.3	0.3	0.3	-0.5	0.6
Total heroin consumption	1.0	1.2	1.6	0.9	-1.3
Area under the delay curve	0.4	0.5	0.5	0.7	-0.7
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.3	-0.2
Delay disc. indifference point, 16s delay	2.1	2.2	2.5	1.6	-1.3
Delay disc. indifference point, 2s delay	0.6	0.7	0.9	0.7	-0.9
Delay disc. indifference point, 24s delay	0.3	0.3	0.3	0.5	-0.5
Delay disc. indifference point, 4s delay	0.5	0.5	0.6	0.7	-0.8
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	-0.4	0.3
Delay discount exponential model param	0.5	0.6	0.6	-0.7	0.8
Delay discount hyperbolic model param	0.5	0.5	0.5	-0.7	0.7
Fecal boli incidents, locomotor time 1	10.0	10.9	11.0	3.3	-3.3
Change in fecal boli incidents, locomotor task	8.0	7.5	8.0	-2.8	2.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.3	-0.3
Bouts of movement, locomotor time 1	1.8	2.0	2.1	1.3	-1.5
Total resting periods, locomotor time 1	1.6	1.7	1.9	1.3	-1.4
Rest time, locomotor task time 1	1.0	1.1	1.3	0.9	-1.1
Distance moved, locomotor task time 1	2.3	2.5	2.7	-1.5	1.6
Vertical activity count, locomotor time 1	0.2	0.2	0.3	-0.4	0.5
Time >=10cm from walls, locomotor time 2	5.9	6.2	6.5	-2.5	2.4
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.2	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.1	-0.1
Rest time, locomotor task time 2	2.2	2.5	3.1	1.4	-1.8
Distance moved, locomotor task time 2	3.4	4.0	4.4	-1.9	2.1
Vertical activity count, locomotor time 2	2.5	2.7	3.3	-1.5	1.8
Weight adjusted by age	1.8	2.0	2.4	1.6	-1.3
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	-0.3	0.5
Locomotion in novel chamber	0.5	0.6	0.7	-0.8	0.7
Locomotion in novel chamber post-restriction	1.6	1.9	2.0	1.3	-1.4
Progressive ratio	0.4	0.4	0.5	-0.7	0.6
Food seeking constrained by brief footshock	1.6	1.9	2.3	-1.2	1.5
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	-0.3
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.2	-0.0
Run reversals in cocaine runway, males	3.7	3.6	3.8	1.9	-1.8
Latency to leave start box in cocaine runway	0.1	0.1	0.1	0.2	-0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.2	0.3
Latency to leave start box in cocaine runway, M	0.5	0.5	0.5	0.7	-0.7
Cd content in liver	2.3	2.5	2.8	-1.5	1.7
Co content in liver	1.5	1.8	2.0	1.4	-1.2
Cu content in liver	1.0	1.2	1.3	1.1	-1.1
Fe content in liver	0.7	0.9	0.9	1.0	-0.9
K content in liver	1.9	1.9	2.1	1.4	-1.3
Mg content in liver	2.5	2.6	2.6	1.6	-1.6
Mn content in liver	1.8	2.0	2.2	1.4	-1.5
Na content in liver	0.2	0.3	0.3	0.5	-0.5
Rb content in liver	1.0	1.2	1.5	1.2	-0.9
Se content in liver	4.7	5.6	5.7	2.4	-2.4
Sr content in liver	0.6	0.6	0.7	0.7	-0.8
Zn content in liver	0.2	0.2	0.2	0.4	-0.4