Ywhae

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	ENSRNOG00000005290	0.31	0.15	3.4e-10	0.12	0.1	0.12	0.02	1.8e-11	1.4e-09	6.6e-11	1.1e-02
2	Liver	isoform ratio	ENSRNOT00000007100	0.14	0.13	5.8e-03	0.02	0.01	0.01	0.02	2.0e-03	5.9e-02	7.7e-03	5.0e-03
3	Liver	isoform ratio	ENSRNOT00000108372	0.16	0.12	5.9e-03	0.02	0.01	0.02	0.02	1.4e-03	5.0e-02	2.0e-03	2.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
BMI with tail	0.3	0.9	2.1	-1.4	-0.5	0.5
BMI without tail	0.2	0.4	0.5	-0.7	-0.6	0.6
Body weight	1.4	6.1	8.8	-0.8	-3.0	3.0
Epididymis fat weight	2.9	6.8	8.7	-1.7	-3.0	3.0
Glucose	2.2	3.4	5.3	2.3	1.6	-1.6
Heart weight	0.0	0.0	0.1	0.3	-0.2	0.2
Left kidney weight	1.9	5.4	15.7	4.0	0.4	-0.4
Right kidney weight	1.4	4.0	11.9	3.5	-0.0	0.0
Tail length	2.5	7.4	10.5	1.1	-3.2	3.2
Length with tail	1.8	6.5	9.6	0.5	-3.1	3.1
Length without tail	1.2	2.7	4.0	-0.3	-2.0	2.0
Liver weight, left	1.3	2.1	3.1	0.1	-1.8	1.8
Liver weight, right	1.0	1.6	2.4	-0.3	-1.5	1.5
Parametrial fat weight	7.2	14.2	17.3	-2.8	-4.2	4.2
Retroperitoneal fat weight	0.1	0.3	0.7	0.8	-0.4	0.4
Intraocular pressure	0.5	0.8	1.1	-0.3	1.1	-1.1
Extensor digitorum longus weight	2.1	8.4	20.5	-4.5	-1.5	1.5
Soleus weight	3.2	9.3	12.1	-1.9	-3.5	3.5
Tibialis anterior weight	4.0	13.9	26.5	-5.1	-2.8	2.8
Tibia length	0.5	1.5	1.8	1.4	-1.2	1.2
Number of licking bursts	0.4	0.5	1.5	1.2	0.2	-0.2
Food consumed during 24 hour testing period	0.2	0.3	0.5	-0.7	-0.4	0.4
Times rat made contact with spout	0.6	0.7	1.9	1.4	0.4	-0.4
Mean time between licks in bursts	0.9	1.2	1.3	1.1	-1.1	1.1
Mean num. licks in bursts	0.0	0.1	0.2	-0.4	0.0	-0.0
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.2	-0.1	0.1
Water consumed over 24 hours	0.4	0.5	0.5	0.7	-0.7	0.7
Indifference point 0 sec	0.1	0.2	0.6	-0.8	0.1	-0.1
Indifference point AUC	0.4	0.5	0.7	0.4	0.8	-0.8
Indifference point function ln k	0.5	0.8	1.3	-1.1	-0.7	0.7
Indifference point function log k	0.5	0.8	1.3	-1.1	-0.7	0.7
Delay discounting total patch changes 0 sec	0.2	0.3	0.7	-0.8	0.2	-0.2
Delay discounting total patch changes 12 sec	0.5	0.6	0.7	0.9	0.8	-0.8
Delay discounting total patch changes 18 sec	0.7	1.0	2.6	1.6	0.4	-0.4
Delay discounting total patch changes 24 sec	1.0	1.2	1.5	1.2	1.0	-1.0
Delay discounting total patch changes 6 sec	0.5	0.7	1.1	-0.1	1.1	-1.1
Delay discounting time to switch 0 sec	0.5	0.8	2.4	1.5	-0.2	0.2
Delay discounting water rate 0 sec	0.2	0.4	0.5	-0.7	0.5	-0.5
Delay discounting water rate 12 sec	0.1	0.1	0.2	0.1	-0.4	0.4
Delay discounting water rate 18 sec	1.6	2.1	2.5	-1.6	-1.4	1.4
Delay discounting water rate 24 sec	0.1	0.1	0.2	-0.4	0.3	-0.3
Delay discounting water rate 6 sec	0.3	0.5	0.7	0.2	0.9	-0.9
Locomotor activity	0.1	0.1	0.2	0.4	-0.3	0.3
Locomotor testing distance	0.1	0.1	0.2	0.2	-0.4	0.4
Locomotor testing rearing	0.0	0.0	0.1	-0.2	-0.0	0.0
Light reinforcement 1	0.1	0.1	0.3	0.6	-0.2	0.2
Light reinforcement 2	1.7	2.2	6.0	2.4	0.6	-0.6
Reaction time number correct	0.0	0.0	0.0	-0.1	-0.0	0.0
Reaction time mean minus median	0.1	0.1	0.1	-0.1	0.4	-0.4
Reaction time mean minus median AUC	0.3	0.4	1.1	-1.0	-0.2	0.2
Reaction time num false alarms	0.7	0.9	1.3	-0.4	1.1	-1.1
Reaction time num false alarms AUC	0.8	1.2	1.7	-0.4	1.3	-1.3
Reaction time trials correct on left	0.0	0.0	0.0	-0.1	-0.0	0.0
Reaction time trials on left	0.0	0.0	0.0	-0.2	0.0	-0.0
Reaction time mean	0.0	0.0	0.0	-0.1	-0.1	0.1
Reaction time mean AUC	0.1	0.1	0.1	-0.1	0.4	-0.4
Median of all reaction times	0.0	0.0	0.0	0.2	-0.1	0.1
Reaction time omissions	0.0	0.0	0.1	-0.3	0.1	-0.1
Reaction time false alarm rate	0.5	0.8	1.1	-0.5	1.0	-1.0
Reaction time premature initiation rate	0.3	0.4	1.1	-1.0	-0.3	0.3
Reaction time premature initiations	0.3	0.4	1.1	-1.1	-0.3	0.3
Std. dev. reaction times	0.2	0.3	0.3	-0.5	0.5	-0.5
Reaction time trials completed	0.0	0.0	0.0	-0.2	0.0	-0.0
Reaction time trials AUC	0.0	0.0	0.0	-0.2	0.1	-0.1
Social response proportion	2.5	2.8	3.8	-0.9	-1.9	1.9
Social responses	1.3	1.7	2.4	-0.6	-1.5	1.5
Social time	2.4	3.1	3.5	-1.5	-1.9	1.9
Conditioned locomotion	0.7	0.8	1.2	-0.3	1.1	-1.1
Cocaine response after cond. corrected	0.6	0.7	0.8	-0.6	-0.9	0.9
Cocaine response after cond. not corrected	1.0	1.1	1.4	-0.7	-1.2	1.2
Cocaine response before conditioning	0.4	0.5	0.6	-0.4	-0.8	0.8
Saline control response	0.1	0.1	0.1	-0.3	-0.4	0.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.4	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	0.0	-0.5	0.5
Condit. Reinf. active responses	0.0	0.1	0.1	-0.3	-0.2	0.2
Condit. Reinf. inactive responses	0.2	0.3	0.3	-0.5	0.6	-0.6
Condit. Reinf. lever presses	1.0	1.3	1.7	0.8	1.3	-1.3
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	-0.2	0.0	-0.0
Pavlov. Cond. lever latency	1.2	1.7	2.6	-1.6	-1.1	1.1
Pavlov. Cond. magazine entry latency	1.1	1.3	3.9	2.0	0.0	-0.0
Pavlov. Cond. change in total contacts	1.0	1.3	2.6	1.6	0.8	-0.8
Pavlov. Cond. index score	1.7	2.3	4.4	2.1	1.1	-1.1
Pavlov. Cond. latency score	2.2	2.8	4.8	2.2	1.3	-1.3
Pavlov. Cond. lever contacts	0.8	1.1	2.7	1.6	0.6	-0.6
Pavlov. Cond. magazine entry number	1.0	1.3	3.3	-1.8	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	1.3	1.6	3.8	-2.0	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	3.7	1.9	1.0	-1.0
Pavlov. Cond. response bias	1.0	1.4	3.6	1.9	0.5	-0.5
Conditioned reinforcement - actives	1.6	1.5	4.2	-2.1	-0.4	0.4
Conditioned reinforcement - inactives	0.3	0.4	1.2	-1.1	-0.1	0.1
Conditioned locomotion	0.8	1.0	1.2	0.7	1.1	-1.1
Intermittent access intake day 1-15 change	1.1	1.1	1.4	-0.8	1.2	-1.2
Intermittent access intake escalation	1.2	1.2	1.8	0.0	1.3	-1.3
Intermittent access intake escalation 2	1.1	1.1	1.5	0.6	1.2	-1.2
Intermitt. access day 1 inactive lever presses	1.9	2.0	2.2	1.3	1.5	-1.5
Intermitt. access day 15 inactive lever presses	0.6	0.7	0.8	0.6	0.9	-0.9
Intermitt. access escalation Index	4.8	4.3	6.4	-0.0	-2.5	2.5
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.4	-0.3	0.3
Intermittent access day 15 total infusions	0.5	0.6	0.7	-0.8	0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.6	0.7	1.6	-1.2	-0.5	0.5
Intermittent access total infusions	0.2	0.2	0.4	-0.6	0.4	-0.4
Intermittent access day 1 locomotion	0.6	0.6	1.2	1.1	0.6	-0.6
Intermittent access day 15 total locomotion	0.8	0.8	1.1	0.7	1.0	-1.0
Intermittent access total locomotion	0.2	0.2	0.3	0.4	0.5	-0.5
Intermittent access standard deviation	2.7	2.8	3.9	-0.9	2.0	-2.0
Cocaine induced anxiety	0.3	0.3	0.5	-0.1	0.7	-0.7
Post-drug Anxiety	0.0	0.0	0.0	-0.1	-0.1	0.1
Baseline Anxiety	0.2	0.2	0.3	0.1	-0.5	0.5
Lifetime Intake	0.4	0.4	0.6	-0.8	0.6	-0.6
Incentive Sensitization - Responses	0.2	0.2	0.2	-0.4	0.4	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	-0.4	0.3	-0.3
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.3	-0.1	0.1
Progressive ratio test 1 breakpoint	0.3	0.3	0.4	-0.7	-0.4	0.4
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.3	0.3	1.1	-1.1
Progressive ratio test 2 active lever presses	0.2	0.3	0.4	-0.7	0.4	-0.4
Progressive ratio test 2 breakpoint	0.3	0.3	0.5	-0.7	0.5	-0.5
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.0	-0.3	1.0	-1.0
Total sessions with >9 infusions	0.1	0.1	0.2	-0.4	0.3	-0.3
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.6	-0.2	0.2
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.0	0.0	-0.0
Short access day 1 total infusions	1.6	1.7	2.4	-0.5	1.6	-1.6
Short access day 10 total infusions	0.3	0.4	1.0	-1.0	0.3	-0.3
Short access total infusions	0.7	0.8	0.8	-0.8	0.9	-0.9
Short access day 1 locomotion	1.0	1.0	1.5	0.2	1.2	-1.2
Short access day 10 total locomotion	0.9	0.9	1.3	0.5	1.1	-1.1
Short access total locomotion	1.1	1.2	1.7	0.1	1.3	-1.3
Compulsive drug intake	0.1	0.1	0.2	0.1	-0.5	0.5
One hour access (0.3 mA shock)	0.6	0.7	1.9	-1.4	0.4	-0.4
One hour access (shock baseline)	0.3	0.4	0.9	-0.9	0.4	-0.4
Number of responses in last shaping day	1.8	1.8	2.4	0.7	1.6	-1.6
Context. condit. distance diff. score	1.5	1.8	2.1	-1.1	-1.5	1.5
Locomotion velocity, session 1	3.3	3.6	4.1	-1.6	-2.0	2.0
Locomotion distance, session 1	0.1	0.1	0.1	-0.4	-0.3	0.3
Locomotion velocity, session 2	0.5	0.6	0.8	-0.6	-0.9	0.9
Locomotion distance, session 2	0.5	0.7	1.1	-1.0	-0.7	0.7
Locomotion velocity, session 3	3.9	4.5	8.5	2.9	1.6	-1.6
Locomotion distance, session 3	0.6	0.6	0.9	0.2	1.0	-1.0
Stereotopy head waving bouts, day 3	0.2	0.3	0.3	0.6	-0.5	0.5
Stereotopy head waving duration, day 3	0.5	0.6	1.5	1.2	0.4	-0.4
Locomotion velocity, session 7	0.5	0.6	1.8	-1.3	0.1	-0.1
Locomotion distance, session 7	1.0	1.3	3.7	-1.9	-0.4	0.4
Stereotopy head waving bouts, day 7	0.4	0.4	0.6	0.1	-0.8	0.8
Stereotopy head waving duration, day 7	0.4	0.5	0.7	-0.0	-0.8	0.8
Locomotion velocity, session 8	0.1	0.1	0.2	-0.4	-0.3	0.3
Locomotion distance, session 8	1.7	2.5	3.4	-0.8	-1.9	1.9
Degree of sensitization distance	2.0	2.0	2.1	-1.4	-1.5	1.5
Degree of sensitization stereotypy	1.0	1.1	1.6	-0.3	-1.3	1.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.6	0.1	-0.1
Condit. Reinf. active-inactive response ratio	1.0	1.1	3.2	1.8	0.2	-0.2
Condit. Reinf. active responses	0.3	0.4	1.1	-1.0	-0.1	0.1
Condit. Reinf. inactive responses	2.6	3.1	9.1	-3.0	-0.2	0.2
Incentive salience index mean	0.0	0.0	0.1	0.3	-0.1	0.1
Condit. Reinf. lever presses	0.6	0.8	1.0	-0.5	-1.0	1.0
Time in familiar zone, hab. session 1	1.1	1.0	2.5	-1.6	0.6	-0.6
Time in novel zone, hab. session 1	1.1	1.0	2.4	1.5	-0.6	0.6
Total zone transitions, hab. session 1	0.1	0.1	0.3	-0.5	-0.1	0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.2	0.1	-0.5	0.5
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.1	-0.3	0.3
Time in familiar zone, hab. session 2	0.6	0.6	1.4	-1.2	-0.5	0.5
Time in novel zone, hab. session 2	1.7	1.8	4.1	2.0	0.8	-0.8
Total zone transitions, hab. session 2	0.3	0.4	0.6	-0.2	-0.8	0.8
Total locomotion distance, hab. session 2	0.2	0.2	0.3	0.3	-0.5	0.5
Locomotion velocity, hab. session 2	0.1	0.2	0.2	0.3	-0.4	0.4
Novel to familiar place preference ratio	0.8	0.9	1.1	-0.6	1.1	-1.1
Novelty place preference	0.3	0.4	0.4	-0.6	0.6	-0.6
Time in novel zone, NPP test	0.2	0.2	0.5	-0.7	0.3	-0.3
Total zone transitions, NPP test	0.1	0.1	0.1	0.3	-0.3	0.3
Total locomotion distance, NPP test	0.1	0.2	0.6	0.7	0.1	-0.1
Locomotion velocity, NPP test	0.4	0.5	0.7	0.9	0.6	-0.6
Pavlov. Cond. lever latency	0.1	0.2	0.2	-0.5	0.4	-0.4
Pavlov. Cond. magazine entry latency	0.7	0.9	1.0	-1.0	-0.9	0.9
Pavlov. Cond. change in total contacts	0.2	0.2	0.6	0.8	0.3	-0.3
Pavlov. Cond. index score	0.5	0.6	0.8	-0.3	-0.9	0.9
Pavlov. Cond. latency score	0.6	0.7	1.1	-0.1	-1.1	1.1
Pavlov. Cond. lever contacts	0.2	0.2	0.2	0.4	-0.5	0.5
Pavlov. Cond. magazine entry number	0.3	0.3	0.4	0.6	0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.1	0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	-0.4	-0.8	0.8
Pavlov. Cond. response bias	0.3	0.4	0.5	-0.5	-0.7	0.7
Bone: apparent density	3.0	5.0	6.6	-2.6	-2.1	2.1
Bone surface	1.2	2.1	3.5	-1.9	-1.2	1.2
Bone volume	1.6	2.7	4.2	-2.1	-1.4	1.4
Bone: connectivity density	3.3	5.2	8.5	-2.9	-1.9	1.9
Bone: cortical apparent density	0.2	0.3	0.4	0.0	0.6	-0.6
Bone: cortical area	1.1	1.7	1.7	1.3	1.3	-1.3
Bone: cortical porosity	0.1	0.2	0.2	-0.4	-0.4	0.4
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.1	0.1
Bone: cortical thickness	2.7	4.4	8.2	2.9	1.6	-1.6
Bone: cortical thickness	0.3	0.3	0.9	1.0	0.1	-0.1
Bone: cortical tissue density	0.1	0.1	0.2	-0.1	0.5	-0.5
Bone: elastic displacement	0.5	0.6	0.8	0.4	0.9	-0.9
Bone: elastic work	3.3	4.3	5.8	2.4	1.9	-1.9
Bone: endosteal estimation	0.0	0.1	0.1	-0.2	0.4	-0.4
Bone: endosteal perimeter	0.3	0.7	1.9	-1.4	0.3	-0.3
Bone: final force	0.6	0.9	2.2	1.5	0.5	-0.5
Bone: final moment	0.5	0.9	1.8	1.4	0.7	-0.7
Bone: marrow area	0.0	0.1	0.1	-0.2	0.3	-0.3
Bone: maximum diameter	0.5	0.9	1.0	-0.9	1.0	-1.0
Bone: maximum force	0.6	1.1	2.6	1.6	0.6	-0.6
Bone: maximum moment	0.6	1.1	2.1	1.5	0.8	-0.8
Bone: minimum diameter	0.4	0.7	2.0	1.4	0.1	-0.1
Bone: periosteal estimation	0.3	0.7	0.7	0.7	0.9	-0.9
Bone: periosteal perimeter	0.3	0.5	0.8	-0.2	0.9	-0.9
Bone: post-yield work	0.2	0.3	0.5	-0.1	-0.7	0.7
Bone: stiffness	0.6	0.9	1.3	-0.4	-1.2	1.2
Bone: tissue strength	2.0	2.0	3.3	1.8	1.2	-1.2
Bone: trabecular number	2.9	4.4	5.7	-2.4	-1.9	1.9
Bone: trabecular spacing	0.9	1.2	1.5	0.6	1.2	-1.2
Bone: trabecular thickness	0.3	0.3	0.4	-0.5	-0.6	0.6
Bone: trabecular tissue density	1.1	1.5	2.8	1.7	0.9	-0.9
Breakpoint value in progressive ratio session	1.2	1.3	2.0	-0.2	-1.4	1.4
Distance traveled before self-admin	2.0	2.2	3.2	1.8	1.3	-1.3
Distance traveled after self-admin	0.0	0.0	0.1	0.3	0.0	-0.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.3	0.4	0.6	-0.6
Delta time in open arm before/after self-admin	0.5	0.5	0.7	-0.3	-0.9	0.9
Diff in mean of infusions in LGA sessions	0.9	1.1	1.4	-0.6	-1.2	1.2
Extinction: sum of active levers before priming	1.4	1.5	2.3	-1.5	-1.0	1.0
Active lever presses in extinction session 6	0.5	0.5	0.9	-0.9	-0.6	0.6
Delta distance traveled before/after self-admin	1.9	2.0	2.0	-1.4	-1.4	1.4
Delta ambulatory time before/after self-admin	1.6	1.7	1.8	-1.3	-1.3	1.3
Time in closed arm before self-admin	2.2	2.5	3.2	-1.0	-1.8	1.8
Time in closed arm after self-admin	0.0	0.0	0.1	0.3	-0.1	0.1
Time in open arm before self-admin	4.0	4.3	4.5	1.9	2.1	-2.1
Time in open arm after self-admin	1.3	1.4	1.8	0.8	1.3	-1.3
Sum of active levers in priming session hrs 5-6	1.7	1.7	2.0	-1.0	-1.4	1.4
Time to tail flick, vehicle, before self-admin	4.5	4.6	5.4	-2.3	-2.0	2.0
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.6	-0.8	0.0	-0.0
Time to tail flick, test, before self-admin	0.3	0.3	0.6	-0.8	-0.4	0.4
Time to tail flick, test, after self-admin	0.5	0.5	0.7	-0.5	-0.8	0.8
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	2.1	0.6	1.4	-1.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.5	0.1	-0.1
Ambulatory time before self-admin	2.0	2.1	4.5	2.1	0.9	-0.9
Ambulatory time after self-admin	0.7	0.8	1.1	0.5	-1.0	1.0
Total heroin consumption	2.8	3.4	3.7	-1.7	-1.9	1.9
Area under the delay curve	1.5	1.6	3.4	1.8	0.8	-0.8
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.5	0.0	-0.0
Delay disc. indifference point, 16s delay	0.7	0.8	1.8	1.3	0.5	-0.5
Delay disc. indifference point, 2s delay	1.0	1.1	2.9	1.7	0.5	-0.5
Delay disc. indifference point, 24s delay	0.3	0.3	0.7	0.9	0.3	-0.3
Delay disc. indifference point, 4s delay	0.7	0.8	2.3	1.5	0.0	-0.0
Delay disc. indifference point, 8s delay	0.6	0.6	1.5	1.2	0.4	-0.4
Delay discount exponential model param	1.3	1.4	3.2	-1.8	-0.7	0.7
Delay discount hyperbolic model param	1.3	1.4	3.1	-1.8	-0.7	0.7
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.1	-0.2	0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.5	-0.1	0.1
Time >=10cm from walls, locomotor time 1	0.7	0.7	0.8	-0.9	0.8	-0.8
Bouts of movement, locomotor time 1	0.2	0.2	0.6	-0.8	-0.0	0.0
Total resting periods, locomotor time 1	0.4	0.4	1.2	-1.1	0.0	-0.0
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.7	0.4	-0.4
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.4	0.1	-0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.6	-0.8	-0.0	0.0
Time >=10cm from walls, locomotor time 2	1.8	1.9	2.6	0.7	1.6	-1.6
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.5	-0.2	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.1	0.2	-0.3	0.3
Rest time, locomotor task time 2	0.5	0.5	0.9	-1.0	-0.6	0.6
Distance moved, locomotor task time 2	0.7	0.8	1.0	0.6	1.0	-1.0
Vertical activity count, locomotor time 2	0.5	0.5	0.8	0.9	0.6	-0.6
Weight adjusted by age	0.5	0.5	1.3	-1.2	-0.3	0.3
Seeking ratio, delayed vs. immediate footshock	2.4	2.8	3.1	1.5	1.8	-1.8
Locomotion in novel chamber	3.8	4.8	7.1	0.4	2.7	-2.7
Locomotion in novel chamber post-restriction	0.2	0.2	0.3	-0.6	0.4	-0.4
Progressive ratio	0.6	0.7	0.9	-0.6	0.9	-0.9
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.4	0.2	-0.2
Seeking ratio, punishment vs. effort	0.6	0.7	1.6	1.3	-0.5	0.5
Run reversals in cocaine runway, females	0.7	0.7	0.9	0.5	0.9	-0.9
Run reversals in cocaine runway, males	0.3	0.3	0.7	-0.8	0.3	-0.3
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.5	0.1	-0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	0.7	-0.3	0.3
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.0	-0.0	0.0
Cd content in liver	1.1	1.2	1.6	-0.7	-1.3	1.3
Co content in liver	0.3	0.4	0.6	0.8	0.5	-0.5
Cu content in liver	0.3	0.4	0.9	1.0	0.3	-0.3
Fe content in liver	0.6	0.8	1.1	0.2	-1.0	1.0
K content in liver	0.9	0.9	2.1	1.4	-0.6	0.6
Mg content in liver	0.3	0.3	0.4	0.3	0.6	-0.6
Mn content in liver	0.0	0.0	0.0	-0.2	-0.1	0.1
Na content in liver	1.9	2.0	5.0	2.2	0.7	-0.7
Rb content in liver	0.6	0.8	2.3	-1.5	0.0	-0.0
Se content in liver	0.4	0.5	1.2	1.1	0.5	-0.5
Sr content in liver	0.6	0.5	1.1	-1.0	-0.5	0.5
Zn content in liver	0.4	0.5	1.2	-1.1	0.3	-0.3