| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000004941 | 0.6900 | 0.2800 | 0.0e+00 | 0.419 | 0.417 | 0.421 | 0.420 | 2.8e-50 | 5.0e-50 | 1.4e-50 | 1.7e-50 |
| 2 | BLA | gene expression | ENSRNOG00000004941 | 0.3950 | 0.1579 | 0.0e+00 | 0.279 | 0.283 | 0.274 | 0.282 | 3.1e-15 | 1.7e-15 | 5.3e-15 | 2.0e-15 |
| 3 | Brain | gene expression | ENSRNOG00000004941 | 0.2800 | 0.0690 | 0.0e+00 | 0.364 | 0.365 | 0.371 | 0.370 | 3.2e-35 | 2.3e-35 | 5.3e-36 | 6.3e-36 |
| 4 | IL | gene expression | ENSRNOG00000004941 | 0.5570 | 0.2070 | 2.7e-10 | 0.272 | 0.235 | 0.182 | 0.226 | 3.0e-07 | 2.3e-06 | 3.8e-05 | 3.9e-06 |
| 5 | LHb | gene expression | ENSRNOG00000004941 | 0.3917 | 0.2563 | 1.4e-06 | 0.218 | 0.230 | 0.213 | 0.235 | 6.8e-06 | 3.6e-06 | 8.8e-06 | 2.7e-06 |
| 6 | Liver | gene expression | ENSRNOG00000004941 | 0.4700 | 0.2300 | 0.0e+00 | 0.344 | 0.347 | 0.344 | 0.349 | 1.6e-39 | 8.0e-40 | 1.6e-39 | 4.1e-40 |
| 7 | NAcc | gene expression | ENSRNOG00000004941 | 0.2800 | 0.0770 | 0.0e+00 | 0.322 | 0.307 | 0.318 | 0.317 | 1.4e-24 | 2.6e-23 | 3.2e-24 | 4.0e-24 |
| 8 | OFC | gene expression | ENSRNOG00000004941 | 0.3588 | 0.2354 | 1.6e-06 | 0.235 | 0.258 | 0.231 | 0.243 | 2.6e-06 | 7.6e-07 | 3.4e-06 | 1.8e-06 |
| 9 | PL | gene expression | ENSRNOG00000004941 | 0.2088 | 0.0650 | 0.0e+00 | 0.323 | 0.322 | 0.326 | 0.330 | 3.5e-25 | 4.3e-25 | 2.0e-25 | 8.6e-26 |
| 10 | PL | mRNA stability | ENSRNOG00000004941 | 0.0503 | 0.0445 | 3.7e-04 | 0.042 | 0.039 | 0.031 | 0.038 | 3.6e-04 | 5.5e-04 | 1.9e-03 | 7.3e-04 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Retroperitoneal fat weight | 21.3 | 70.5 | 72.6 | -8.3 | -8.4 | -8.3 | -8.5 | -8.5 | -8.4 | -8.2 | -8.5 | -8.4 | 8.5 |
| Epididymis fat weight | 14.8 | 34.6 | 37.5 | -5.6 | -5.9 | -6.1 | -6.0 | -5.9 | -5.9 | -5.4 | -6.0 | -5.8 | 6.1 |
| Intermitt. access day 15 inactive lever presses | 9.3 | 10.3 | 13.2 | 2.9 | 3.5 | 3.6 | 3.6 | 3.6 | 2.0 | 3.1 | 3.1 | 3.2 | -3.2 |
| Heart weight | 9.1 | 13.1 | 15.4 | -3.9 | -3.5 | -3.4 | -3.3 | -3.4 | -3.9 | -3.9 | -3.6 | -3.7 | 3.5 |
| Liver weight, right | 9.1 | 15.0 | 16.0 | -4.0 | -3.8 | -3.8 | -3.7 | -3.8 | -4.0 | -3.9 | -3.9 | -3.8 | 4.0 |
| Short access day 1 locomotion | 6.8 | 7.2 | 9.3 | 2.9 | 2.8 | 2.7 | 2.6 | 2.6 | 2.0 | 3.0 | 2.6 | 2.8 | -2.7 |
| Parametrial fat weight | 5.7 | 11.1 | 12.4 | -3.5 | -3.3 | -3.3 | -3.2 | -3.2 | -3.2 | -3.5 | -3.3 | -3.3 | 3.4 |
| Intermittent access day 1 total infusions | 5.7 | 6.4 | 8.1 | 2.4 | 2.6 | 2.8 | 2.6 | 2.5 | 2.2 | 2.4 | 2.5 | 2.5 | -2.7 |
| Short access day 1 total inactive lever presses | 5.7 | 6.3 | 8.8 | 2.2 | 2.6 | 3.0 | 2.6 | 2.6 | 1.9 | 2.3 | 2.4 | 2.4 | -3.0 |
| Intraocular pressure | 5.6 | 7.9 | 8.8 | -2.8 | -3.0 | -2.9 | -2.9 | -2.9 | -2.3 | -2.9 | -2.8 | -2.9 | 2.8 |
| Co content in liver | 5.6 | 6.6 | 7.5 | 2.6 | 2.5 | 2.6 | 2.5 | 2.5 | 2.7 | 2.5 | 2.6 | 2.5 | -2.6 |
| Bone: apparent density | 5.5 | 9.1 | 9.6 | 2.9 | 3.0 | 3.1 | 3.1 | 3.1 | 3.0 | 3.0 | 3.1 | 3.1 | -3.0 |
| Short access day 1 total infusions | 5.2 | 5.5 | 6.9 | 2.5 | 2.5 | 2.4 | 2.4 | 2.4 | 1.5 | 2.6 | 2.2 | 2.4 | -2.4 |
| Bone: connectivity density | 5.2 | 8.2 | 8.5 | 2.8 | 2.9 | 2.9 | 2.9 | 2.9 | 2.8 | 2.8 | 2.9 | 2.8 | -2.8 |
| Change in fecal boli incidents, locomotor task | 4.6 | 4.3 | 4.7 | -2.0 | -2.1 | -2.2 | -2.2 | -2.1 | -2.0 | -1.9 | -2.1 | -2.1 | 2.1 |
| Extensor digitorum longus weight | 4.5 | 18.0 | 18.3 | 4.2 | 4.2 | 4.2 | 4.2 | 4.2 | 4.3 | 4.2 | 4.3 | 4.3 | -4.2 |
| Soleus weight | 4.3 | 12.5 | 15.0 | 3.5 | 3.4 | 3.5 | 3.5 | 3.5 | 3.9 | 3.4 | 3.6 | 3.4 | -3.5 |
| Light reinforcement 1 | 4.3 | 7.8 | 9.3 | 2.5 | 2.8 | 3.0 | 2.9 | 2.9 | 2.7 | 2.4 | 2.9 | 2.7 | -2.9 |
| Bone: trabecular number | 4.3 | 6.7 | 7.1 | 2.5 | 2.6 | 2.7 | 2.7 | 2.6 | 2.5 | 2.5 | 2.6 | 2.6 | -2.6 |
| Progressive ratio test 1 inactive lever presses | 4.2 | 4.5 | 5.7 | 2.2 | 2.3 | 2.3 | 2.3 | 2.2 | 1.0 | 2.4 | 2.0 | 2.2 | -2.0 |
| Short access day 10 total infusions | 4.2 | 4.6 | 5.2 | 2.1 | 2.2 | 2.3 | 2.2 | 2.2 | 1.8 | 2.2 | 2.1 | 2.2 | -2.3 |
| Time to tail flick, vehicle, after self-admin | 4.2 | 4.5 | 5.5 | -1.8 | -2.2 | -2.2 | -2.3 | -2.3 | -2.1 | -1.7 | -2.2 | -2.1 | 2.3 |
| Food seeking constrained by brief footshock | 4.0 | 4.9 | 5.9 | 2.4 | 2.3 | 2.2 | 2.2 | 2.2 | 1.8 | 2.4 | 2.1 | 2.3 | -2.3 |
| Light reinforcement 2 | 3.9 | 5.2 | 7.0 | 1.8 | 2.4 | 2.7 | 2.4 | 2.4 | 2.1 | 1.8 | 2.4 | 2.2 | -2.5 |
| Condit. Reinf. active minus inactive responses | 3.9 | 4.9 | 5.6 | 2.3 | 2.1 | 2.2 | 2.1 | 2.1 | 2.4 | 2.2 | 2.2 | 2.2 | -2.3 |
| Bone: trabecular spacing | 3.8 | 4.8 | 5.6 | -2.2 | -2.2 | -2.2 | -2.3 | -2.3 | -1.8 | -2.4 | -2.1 | -2.2 | 2.2 |
| Pavlov. Cond. intertrial magazine entries | 3.7 | 4.7 | 5.2 | -2.1 | -2.3 | -2.3 | -2.3 | -2.3 | -1.8 | -2.2 | -2.2 | -2.2 | 2.1 |
| Tibialis anterior weight | 3.6 | 12.4 | 13.3 | 3.4 | 3.5 | 3.4 | 3.6 | 3.5 | 3.6 | 3.4 | 3.6 | 3.5 | -3.6 |
| Conditioned reinforcement - inactives | 3.4 | 3.8 | 5.9 | 1.7 | 2.0 | 2.4 | 1.9 | 2.0 | 1.3 | 1.8 | 1.9 | 1.9 | -2.3 |
| Lifetime Intake | 3.3 | 3.7 | 4.3 | 1.9 | 2.0 | 2.0 | 1.9 | 1.9 | 1.4 | 2.1 | 1.8 | 2.0 | -2.0 |
| Locomotion velocity, NPP test | 3.3 | 4.8 | 4.9 | 2.1 | 2.2 | 2.2 | 2.2 | 2.2 | 2.2 | 2.2 | 2.2 | 2.2 | -2.2 |
| Condit. Reinf. active responses | 3.2 | 4.4 | 5.0 | 2.2 | 2.0 | 2.1 | 2.0 | 2.0 | 2.2 | 2.1 | 2.1 | 2.1 | -2.2 |
| Conditioned locomotion | 3.1 | 3.7 | 4.1 | 2.0 | 1.9 | 1.8 | 1.9 | 1.9 | 2.0 | 2.0 | 1.9 | 1.9 | -1.8 |
| Short access total infusions | 3.1 | 3.4 | 4.4 | 2.0 | 1.9 | 1.9 | 1.9 | 1.9 | 1.2 | 2.1 | 1.7 | 1.9 | -1.8 |
| Bone volume | 3.1 | 5.2 | 5.8 | 2.1 | 2.3 | 2.4 | 2.4 | 2.4 | 2.1 | 2.3 | 2.3 | 2.3 | -2.2 |
| Bone surface | 2.9 | 5.2 | 5.8 | 2.1 | 2.3 | 2.3 | 2.4 | 2.4 | 2.1 | 2.3 | 2.3 | 2.3 | -2.2 |
| Delay disc. indifference point, 0s delay | 2.9 | 3.1 | 3.8 | -1.8 | -2.0 | -1.8 | -1.9 | -2.0 | -0.7 | -1.9 | -1.7 | -1.8 | 1.6 |
| Total heroin consumption | 2.8 | 3.4 | 3.6 | 1.8 | 1.8 | 1.8 | 1.9 | 1.8 | 1.9 | 1.8 | 1.9 | 1.8 | -1.9 |
| Total resting periods, locomotor time 1 | 2.8 | 3.2 | 4.3 | 1.8 | 1.8 | 1.7 | 1.8 | 1.8 | 2.1 | 1.9 | 1.8 | 1.8 | -1.4 |
| Condit. Reinf. lever reinforcers received | 2.7 | 3.8 | 4.3 | 2.0 | 1.9 | 2.0 | 1.9 | 1.9 | 2.0 | 2.0 | 1.9 | 2.0 | -2.1 |
| Intermittent access day 15 total infusions | 2.7 | 3.0 | 3.9 | 1.5 | 1.9 | 1.9 | 2.0 | 1.8 | 1.1 | 1.6 | 1.7 | 1.8 | -1.8 |
| Mean time between licks in bursts | 2.5 | 3.5 | 3.9 | -1.9 | -1.9 | -1.8 | -1.9 | -1.9 | -1.8 | -2.0 | -1.9 | -1.9 | 1.8 |
| Indifference point AUC | 2.5 | 2.9 | 3.7 | 1.6 | 1.8 | 1.6 | 1.9 | 1.9 | 1.4 | 1.7 | 1.7 | 1.8 | -1.6 |
| Time to tail flick, vehicle, before self-admin | 2.5 | 2.5 | 2.8 | -1.4 | -1.6 | -1.7 | -1.6 | -1.7 | -1.5 | -1.5 | -1.7 | -1.6 | 1.6 |
| Bouts of movement, locomotor time 1 | 2.5 | 2.8 | 4.3 | 1.7 | 1.6 | 1.5 | 1.6 | 1.6 | 2.1 | 1.8 | 1.7 | 1.7 | -1.3 |
| Locomotion in novel chamber post-restriction | 2.5 | 2.9 | 3.7 | -1.5 | -1.8 | -1.8 | -1.9 | -1.9 | -1.4 | -1.6 | -1.7 | -1.7 | 1.7 |
| Progressive ratio test 2 inactive lever presses | 2.4 | 2.8 | 4.1 | 1.5 | 1.9 | 2.0 | 1.8 | 1.7 | 0.7 | 1.7 | 1.5 | 1.8 | -1.7 |
| Total sessions with >9 infusions | 2.4 | 2.6 | 4.0 | 1.9 | 1.7 | 1.6 | 1.6 | 1.6 | 0.9 | 2.0 | 1.4 | 1.7 | -1.5 |
| Tibia length | 2.3 | 6.5 | 7.7 | -2.6 | -2.5 | -2.5 | -2.5 | -2.5 | -2.8 | -2.5 | -2.6 | -2.5 | 2.6 |
| Intermittent access total infusions | 2.3 | 2.6 | 3.2 | 1.6 | 1.6 | 1.7 | 1.6 | 1.6 | 1.2 | 1.7 | 1.5 | 1.7 | -1.8 |
| Intermittent access day 1 locomotion | 2.3 | 2.4 | 3.1 | 1.4 | 1.6 | 1.8 | 1.6 | 1.6 | 1.5 | 1.5 | 1.6 | 1.5 | -1.5 |
| Delay discounting water rate 24 sec | 2.2 | 3.0 | 3.9 | -1.5 | -1.8 | -2.0 | -1.8 | -1.8 | -1.6 | -1.5 | -1.8 | -1.7 | 1.8 |
| Intermittent access terminal intake (last 3 days) | 2.2 | 2.4 | 3.1 | 1.4 | 1.7 | 1.8 | 1.7 | 1.6 | 0.9 | 1.5 | 1.5 | 1.7 | -1.5 |
| Times rat made contact with spout | 2.1 | 2.4 | 2.8 | 1.6 | 1.5 | 1.5 | 1.5 | 1.5 | 1.7 | 1.6 | 1.6 | 1.5 | -1.6 |
| Time in novel zone, NPP test | 2.1 | 2.2 | 2.4 | -1.5 | -1.5 | -1.5 | -1.5 | -1.5 | -1.2 | -1.5 | -1.4 | -1.5 | 1.5 |
| Time in open arm after self-admin | 2.1 | 2.3 | 3.4 | 1.2 | 1.5 | 1.6 | 1.6 | 1.5 | 1.8 | 1.0 | 1.6 | 1.4 | -1.8 |
| Condit. Reinf. lever presses | 2.0 | 2.8 | 3.2 | 1.7 | 1.6 | 1.6 | 1.6 | 1.6 | 1.8 | 1.7 | 1.7 | 1.7 | -1.6 |
| One hour access (0.3 mA shock) | 2.0 | 2.4 | 2.8 | 1.4 | 1.6 | 1.6 | 1.7 | 1.6 | 1.2 | 1.6 | 1.5 | 1.6 | -1.7 |
| One hour access (shock baseline) | 2.0 | 2.3 | 3.2 | 1.6 | 1.5 | 1.5 | 1.5 | 1.4 | 1.0 | 1.8 | 1.4 | 1.7 | -1.6 |
| Locomotion distance, session 1 | 2.0 | 2.6 | 3.0 | 1.4 | 1.6 | 1.7 | 1.7 | 1.7 | 1.6 | 1.5 | 1.6 | 1.6 | -1.7 |
| Total locomotion distance, NPP test | 2.0 | 2.7 | 2.9 | 1.6 | 1.7 | 1.7 | 1.7 | 1.7 | 1.6 | 1.7 | 1.7 | 1.7 | -1.7 |
| Cocaine response after cond. not corrected | 1.9 | 2.1 | 3.0 | 1.4 | 1.4 | 1.5 | 1.4 | 1.4 | 1.7 | 1.3 | 1.5 | 1.4 | -1.5 |
| Pavlov. Cond. lever latency | 1.9 | 2.4 | 2.8 | -1.4 | -1.6 | -1.7 | -1.6 | -1.6 | -1.5 | -1.5 | -1.6 | -1.5 | 1.6 |
| Body weight | 1.8 | 7.8 | 9.5 | -2.7 | -2.8 | -3.0 | -2.8 | -2.8 | -2.7 | -2.5 | -2.8 | -2.7 | 3.1 |
| Water consumed over 24 hours | 1.8 | 2.1 | 2.4 | 1.3 | 1.4 | 1.5 | 1.5 | 1.5 | 1.3 | 1.5 | 1.5 | 1.5 | -1.6 |
| Pavlov. Cond. lever latency | 1.8 | 2.5 | 2.8 | -1.6 | -1.6 | -1.6 | -1.5 | -1.5 | -1.6 | -1.7 | -1.6 | -1.6 | 1.6 |
| Pavlov. Cond. response bias | 1.8 | 2.4 | 2.6 | 1.5 | 1.5 | 1.6 | 1.5 | 1.5 | 1.5 | 1.6 | 1.6 | 1.6 | -1.6 |
| Stereotopy head waving bouts, day 3 | 1.8 | 2.2 | 2.4 | 1.5 | 1.5 | 1.4 | 1.5 | 1.5 | 1.3 | 1.5 | 1.5 | 1.5 | -1.4 |
| Condit. Reinf. inactive responses | 1.8 | 2.1 | 2.4 | 1.3 | 1.4 | 1.5 | 1.5 | 1.5 | 1.5 | 1.4 | 1.5 | 1.5 | -1.5 |
| Novelty place preference | 1.8 | 1.9 | 2.1 | -1.4 | -1.4 | -1.4 | -1.4 | -1.4 | -1.1 | -1.4 | -1.3 | -1.4 | 1.4 |
| Condit. Reinf. inactive responses | 1.7 | 2.1 | 2.4 | 1.5 | 1.4 | 1.5 | 1.4 | 1.4 | 1.5 | 1.5 | 1.4 | 1.5 | -1.5 |
| Baseline Anxiety | 1.7 | 1.7 | 2.3 | -1.3 | -1.4 | -1.5 | -1.3 | -1.3 | -0.7 | -1.5 | -1.2 | -1.4 | 1.3 |
| Progressive ratio test 1 active lever presses | 1.7 | 1.8 | 2.4 | 1.4 | 1.4 | 1.5 | 1.4 | 1.2 | 0.6 | 1.5 | 1.2 | 1.4 | -1.5 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.7 | 2.1 | 2.4 | 1.4 | 1.4 | 1.5 | 1.5 | 1.5 | 1.5 | 1.4 | 1.5 | 1.4 | -1.5 |
| Delay discounting water rate 12 sec | 1.6 | 2.5 | 3.2 | -1.5 | -1.6 | -1.6 | -1.6 | -1.5 | -1.8 | -1.4 | -1.6 | -1.5 | 1.5 |
| Pavlov. Cond. response bias | 1.6 | 1.9 | 2.2 | 1.3 | 1.4 | 1.4 | 1.4 | 1.4 | 1.4 | 1.3 | 1.4 | 1.3 | -1.5 |
| Bone: cortical thickness | 1.6 | 1.8 | 1.9 | 1.3 | 1.4 | 1.3 | 1.4 | 1.4 | 1.3 | 1.3 | 1.4 | 1.4 | -1.3 |
| Length with tail | 1.5 | 5.5 | 6.9 | -2.1 | -2.4 | -2.6 | -2.5 | -2.4 | -2.2 | -2.0 | -2.4 | -2.2 | 2.6 |
| Progressive ratio test 1 breakpoint | 1.5 | 1.6 | 2.1 | 1.3 | 1.3 | 1.4 | 1.3 | 1.2 | 0.5 | 1.4 | 1.1 | 1.3 | -1.4 |
| Total zone transitions, NPP test | 1.5 | 2.1 | 2.2 | 1.4 | 1.4 | 1.5 | 1.5 | 1.5 | 1.5 | 1.4 | 1.5 | 1.5 | -1.5 |
| Delta distance traveled before/after self-admin | 1.5 | 1.6 | 2.2 | -1.3 | -1.1 | -1.3 | -1.1 | -1.0 | -1.5 | -1.3 | -1.2 | -1.2 | 1.4 |
| Time in closed arm after self-admin | 1.5 | 1.5 | 2.2 | -1.0 | -1.3 | -1.3 | -1.4 | -1.3 | -1.3 | -0.9 | -1.3 | -1.1 | 1.5 |
| Rest time, locomotor task time 2 | 1.5 | 1.8 | 2.3 | 1.2 | 1.3 | 1.5 | 1.3 | 1.3 | 1.4 | 1.1 | 1.3 | 1.3 | -1.5 |
| Median of all reaction times | 1.4 | 1.8 | 2.4 | -1.5 | -1.4 | -1.3 | -1.3 | -1.3 | -1.4 | -1.5 | -1.3 | -1.4 | 1.1 |
| Bone: cortical porosity | 1.4 | 1.6 | 2.0 | 1.3 | 1.3 | 1.2 | 1.2 | 1.2 | 1.1 | 1.4 | 1.2 | 1.3 | -1.1 |
| Delay disc. indifference point, 24s delay | 1.4 | 1.3 | 4.6 | 1.2 | 0.7 | 0.7 | 0.8 | 0.8 | 2.2 | 1.0 | 1.2 | 1.0 | -1.3 |
| Delay discounting water rate 6 sec | 1.3 | 1.9 | 2.6 | -1.4 | -1.4 | -1.4 | -1.3 | -1.3 | -1.6 | -1.4 | -1.4 | -1.3 | 1.3 |
| Distance moved, locomotor task time 1 | 1.3 | 1.5 | 1.7 | -1.2 | -1.3 | -1.2 | -1.1 | -1.2 | -1.1 | -1.2 | -1.2 | -1.3 | 1.3 |
| Zn content in liver | 1.3 | 1.4 | 1.6 | -1.1 | -1.2 | -1.2 | -1.3 | -1.2 | -1.2 | -0.9 | -1.2 | -1.1 | 1.2 |
| Reaction time mean | 1.2 | 1.7 | 2.0 | -1.4 | -1.3 | -1.3 | -1.3 | -1.3 | -1.4 | -1.3 | -1.3 | -1.3 | 1.1 |
| Cocaine response before conditioning | 1.2 | 1.5 | 2.3 | 1.2 | 1.2 | 1.3 | 1.2 | 1.2 | 1.0 | 1.1 | 1.2 | 1.2 | -1.5 |
| Pavlov. Cond. index score | 1.2 | 1.6 | 1.9 | 1.2 | 1.3 | 1.3 | 1.3 | 1.3 | 1.0 | 1.4 | 1.2 | 1.4 | -1.4 |
| Pavlov. Cond. latency score | 1.2 | 1.6 | 1.9 | 1.2 | 1.3 | 1.3 | 1.3 | 1.3 | 1.0 | 1.4 | 1.2 | 1.3 | -1.3 |
| Conditioned reinforcement - actives | 1.2 | 1.2 | 2.0 | 1.3 | 1.2 | 0.8 | 1.2 | 1.2 | 0.4 | 1.4 | 0.9 | 1.3 | -0.7 |
| Short access day 10 total inactive lever presses | 1.2 | 1.3 | 2.3 | 0.9 | 1.2 | 1.5 | 1.2 | 1.3 | 0.8 | 1.0 | 1.1 | 1.0 | -1.2 |
| Locomotion velocity, session 7 | 1.2 | 1.3 | 1.6 | 1.1 | 1.2 | 1.2 | 1.2 | 1.2 | 0.9 | 1.1 | 1.1 | 1.2 | -1.2 |
| Pavlov. Cond. lever contacts | 1.2 | 1.4 | 1.6 | 1.1 | 1.2 | 1.2 | 1.2 | 1.2 | 1.2 | 1.1 | 1.2 | 1.1 | -1.3 |
| Bone: cortical porosity | 1.2 | 1.3 | 1.5 | 1.2 | 1.2 | 1.1 | 1.1 | 1.2 | 1.0 | 1.2 | 1.1 | 1.2 | -1.1 |
| Locomotion in novel chamber | 1.2 | 1.5 | 2.7 | -1.0 | -1.2 | -1.6 | -1.1 | -1.1 | -1.1 | -1.0 | -1.2 | -1.1 | 1.5 |
| Right kidney weight | 1.1 | 3.3 | 3.8 | -1.8 | -1.9 | -1.7 | -2.0 | -1.9 | -1.3 | -1.9 | -1.7 | -1.9 | 1.8 |
| Liver weight, left | 1.1 | 1.8 | 2.3 | -1.4 | -1.4 | -1.3 | -1.3 | -1.4 | -1.5 | -1.3 | -1.4 | -1.3 | 1.2 |
| Reaction time mean AUC | 1.1 | 1.4 | 1.8 | -1.3 | -1.2 | -1.1 | -1.2 | -1.2 | -1.2 | -1.3 | -1.2 | -1.2 | 0.9 |
| Locomotion velocity, hab. session 1 | 1.1 | 1.6 | 1.7 | 1.1 | 1.2 | 1.3 | 1.3 | 1.3 | 1.1 | 1.3 | 1.3 | 1.3 | -1.3 |
| Novel to familiar place preference ratio | 1.1 | 1.2 | 1.4 | -1.1 | -1.1 | -1.1 | -1.1 | -1.1 | -0.8 | -1.2 | -1.0 | -1.1 | 1.1 |
| Pavlov. Cond. intertrial magazine entries | 1.1 | 1.3 | 1.7 | 1.2 | 1.1 | 1.2 | 1.1 | 1.1 | 1.3 | 1.1 | 1.2 | 1.2 | -1.1 |
| Breakpoint value in progressive ratio session | 1.1 | 1.2 | 1.9 | 1.4 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.4 | 1.1 | 1.1 | -0.9 |
| Condit. Reinf. active-inactive response ratio | 1.0 | 1.1 | 1.5 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.2 | 0.9 | 1.0 | 1.0 | -1.1 |
| Bone: elastic work | 1.0 | 1.3 | 1.6 | 1.2 | 1.1 | 1.1 | 1.1 | 1.1 | 1.3 | 1.1 | 1.2 | 1.1 | -1.1 |
| Bone: tissue strength | 1.0 | 0.9 | 1.1 | -1.0 | -1.0 | -1.0 | -1.0 | -1.0 | -0.6 | -1.0 | -0.9 | -1.0 | 0.9 |
| Distance moved, locomotor task time 2 | 1.0 | 1.1 | 1.6 | -0.9 | -1.1 | -1.2 | -1.1 | -1.1 | -1.3 | -0.8 | -1.1 | -1.0 | 1.1 |
| Cocaine response after cond. corrected | 0.9 | 1.0 | 1.5 | 0.9 | 1.0 | 1.0 | 1.0 | 1.0 | 1.2 | 0.9 | 1.1 | 0.9 | -0.9 |
| Pavlov. Cond. lever contacts | 0.9 | 1.3 | 1.4 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 | 1.2 | 1.2 | 1.1 | 1.2 | -1.1 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.9 | 1.2 | 1.5 | 1.0 | 1.1 | 1.1 | 1.1 | 1.1 | 0.8 | 1.2 | 1.1 | 1.2 | -1.2 |
| Intermittent access day 15 total locomotion | 0.9 | 1.0 | 1.6 | 0.9 | 1.0 | 1.1 | 1.0 | 1.0 | 0.5 | 1.0 | 0.9 | 1.1 | -1.3 |
| Short access day 10 total locomotion | 0.9 | 1.0 | 1.4 | 0.8 | 1.1 | 1.2 | 1.1 | 1.0 | 0.7 | 0.9 | 1.0 | 1.1 | -1.1 |
| Locomotion distance, session 3 | 0.9 | 1.0 | 1.2 | 0.9 | 1.0 | 1.1 | 1.1 | 1.1 | 0.9 | 0.9 | 1.0 | 1.0 | -1.1 |
| Bone: maximum diameter | 0.9 | 1.7 | 1.9 | 1.2 | 1.3 | 1.3 | 1.4 | 1.4 | 1.3 | 1.3 | 1.3 | 1.3 | -1.4 |
| Bone: trabecular thickness | 0.9 | 1.1 | 1.6 | 1.0 | 1.1 | 1.0 | 1.1 | 1.1 | 0.8 | 1.3 | 1.0 | 1.1 | -0.9 |
| Distance traveled after self-admin | 0.9 | 1.0 | 1.4 | -1.0 | -1.0 | -1.1 | -0.7 | -0.9 | -0.9 | -1.1 | -0.9 | -1.0 | 1.2 |
| Sum of active levers in priming session hrs 5-6 | 0.9 | 0.9 | 1.4 | 0.7 | 0.9 | 1.1 | 0.9 | 0.9 | 1.0 | 0.6 | 1.0 | 0.9 | -1.2 |
| Delay discounting total patch changes 12 sec | 0.8 | 1.0 | 1.2 | -1.0 | -1.0 | -1.1 | -1.0 | -1.0 | -0.9 | -1.1 | -1.0 | -1.0 | 1.1 |
| Reaction time trials AUC | 0.8 | 1.1 | 1.4 | 1.0 | 1.0 | 1.1 | 1.2 | 1.1 | 1.1 | 0.9 | 1.1 | 1.0 | -1.0 |
| Saline control response | 0.8 | 1.1 | 1.2 | 1.0 | 1.1 | 1.1 | 1.1 | 1.1 | 0.8 | 1.1 | 1.0 | 1.1 | -1.1 |
| Degree of sensitization distance | 0.8 | 0.8 | 1.0 | -0.9 | -0.9 | -0.9 | -0.9 | -0.9 | -1.0 | -0.7 | -0.9 | -0.8 | 0.9 |
| Condit. Reinf. active-inactive response ratio | 0.8 | 0.9 | 1.1 | -0.8 | -1.0 | -0.9 | -0.9 | -1.0 | -0.6 | -1.0 | -0.9 | -1.0 | 1.0 |
| Time in novel zone, hab. session 1 | 0.8 | 0.8 | 0.9 | -0.7 | -0.9 | -0.9 | -0.9 | -0.9 | -0.8 | -0.8 | -0.9 | -0.9 | 0.9 |
| Pavlov. Cond. index score | 0.8 | 1.0 | 1.3 | 0.9 | 1.0 | 1.1 | 1.1 | 1.1 | 1.0 | 0.9 | 1.0 | 1.0 | -1.1 |
| Pavlov. Cond. latency score | 0.8 | 1.0 | 1.2 | 0.9 | 1.0 | 1.1 | 1.1 | 1.1 | 0.9 | 0.9 | 1.0 | 0.9 | -1.1 |
| Length without tail | 0.7 | 1.5 | 1.7 | -1.3 | -1.3 | -1.2 | -1.2 | -1.2 | -1.0 | -1.3 | -1.2 | -1.2 | 1.3 |
| Delay discounting total patch changes 24 sec | 0.7 | 0.9 | 1.5 | -0.9 | -0.9 | -1.0 | -0.8 | -0.8 | -1.2 | -0.9 | -1.0 | -0.9 | 1.1 |
| Locomotor testing rearing | 0.7 | 1.0 | 1.8 | 1.3 | 1.0 | 0.8 | 0.9 | 0.9 | 1.0 | 1.3 | 1.0 | 1.1 | -0.8 |
| Pavlov. Cond. change in total contacts | 0.7 | 1.0 | 1.3 | 1.0 | 0.9 | 1.0 | 0.9 | 0.9 | 1.0 | 1.1 | 1.0 | 1.0 | -1.1 |
| Post-drug Anxiety | 0.7 | 0.8 | 1.4 | -1.2 | -0.8 | -0.7 | -0.8 | -0.8 | -0.9 | -1.1 | -0.8 | -0.9 | 0.9 |
| Short access total locomotion | 0.7 | 0.7 | 1.0 | 0.9 | 0.9 | 1.0 | 0.9 | 0.8 | 0.4 | 0.9 | 0.7 | 0.9 | -0.7 |
| Bone: elastic displacement | 0.7 | 0.8 | 1.1 | 1.0 | 0.8 | 0.8 | 0.8 | 0.8 | 1.1 | 0.9 | 0.9 | 0.9 | -0.9 |
| Bone: periosteal estimation | 0.7 | 1.4 | 1.6 | 1.1 | 1.2 | 1.2 | 1.3 | 1.2 | 1.1 | 1.2 | 1.2 | 1.2 | -1.1 |
| Delay discounting water rate 18 sec | 0.6 | 0.9 | 1.2 | -0.9 | -0.9 | -0.8 | -1.0 | -0.9 | -1.1 | -0.9 | -0.9 | -0.8 | 1.0 |
| Reaction time number correct | 0.6 | 0.8 | 1.1 | 0.8 | 0.9 | 0.9 | 1.0 | 1.0 | 0.9 | 0.8 | 0.9 | 0.9 | -0.9 |
| Reaction time trials correct on left | 0.6 | 0.8 | 1.1 | 0.8 | 0.9 | 0.9 | 1.0 | 1.0 | 0.9 | 0.8 | 0.9 | 0.9 | -0.9 |
| Reaction time trials on left | 0.6 | 0.9 | 1.1 | 0.9 | 0.9 | 0.9 | 1.1 | 1.0 | 0.9 | 0.8 | 0.9 | 0.9 | -0.9 |
| Reaction time trials completed | 0.6 | 0.9 | 1.1 | 0.9 | 0.9 | 0.9 | 1.1 | 1.0 | 0.9 | 0.8 | 0.9 | 0.9 | -0.9 |
| Locomotion velocity, session 3 | 0.6 | 0.7 | 0.8 | 0.9 | 0.9 | 0.8 | 0.9 | 0.9 | 0.7 | 0.7 | 0.8 | 0.8 | -0.9 |
| Condit. Reinf. active minus inactive responses | 0.6 | 0.7 | 1.0 | -0.8 | -0.9 | -0.8 | -0.9 | -0.9 | -0.6 | -1.0 | -0.8 | -0.9 | 0.8 |
| Condit. Reinf. lever presses | 0.6 | 0.8 | 1.3 | 0.8 | 0.8 | 0.9 | 0.9 | 0.8 | 1.1 | 0.7 | 0.9 | 0.8 | -1.0 |
| Time in familiar zone, hab. session 1 | 0.6 | 0.6 | 0.9 | -0.7 | -0.7 | -0.8 | -0.8 | -0.8 | -0.9 | -0.7 | -0.8 | -0.7 | 0.8 |
| Time in novel zone, hab. session 2 | 0.6 | 0.6 | 0.7 | -0.7 | -0.9 | -0.8 | -0.9 | -0.9 | -0.5 | -0.8 | -0.8 | -0.8 | 0.8 |
| Ambulatory time after self-admin | 0.6 | 0.6 | 1.1 | -0.9 | -0.7 | -0.9 | -0.4 | -0.7 | -0.7 | -0.9 | -0.7 | -0.8 | 1.1 |
| Vertical activity count, locomotor time 1 | 0.6 | 0.6 | 0.8 | -0.8 | -0.8 | -0.7 | -0.7 | -0.8 | -0.6 | -0.8 | -0.7 | -0.9 | 0.9 |
| Latency to leave start box in cocaine runway, F | 0.6 | 0.7 | 1.1 | 0.7 | 0.8 | 0.8 | 0.9 | 0.9 | 0.8 | 0.7 | 0.8 | 0.8 | -1.0 |
| Latency to leave start box in cocaine runway, M | 0.6 | 0.5 | 0.9 | 0.9 | 0.8 | 0.4 | 0.8 | 0.9 | 0.3 | 0.9 | 0.7 | 0.8 | -0.4 |
| Mn content in liver | 0.6 | 0.7 | 0.8 | 0.9 | 0.9 | 0.8 | 0.8 | 0.8 | 0.7 | 0.8 | 0.8 | 0.8 | -0.7 |
| Compulsive drug intake | 0.5 | 0.5 | 0.8 | -0.7 | -0.8 | -0.7 | -0.6 | -0.6 | -0.1 | -0.9 | -0.6 | -0.8 | 0.5 |
| Number of responses in last shaping day | 0.5 | 0.5 | 1.0 | 0.8 | 0.8 | 0.6 | 0.8 | 0.7 | 0.1 | 1.0 | 0.6 | 0.9 | -0.6 |
| Locomotion velocity, hab. session 2 | 0.5 | 0.6 | 0.7 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 | -0.8 |
| Pavlov. Cond. magazine entry number | 0.5 | 0.6 | 0.8 | -0.7 | -0.8 | -0.9 | -0.9 | -0.8 | -0.7 | -0.7 | -0.8 | -0.8 | 0.9 |
| Bone: endosteal estimation | 0.5 | 1.0 | 1.3 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 0.9 | 1.1 | 1.0 | 1.0 | -0.9 |
| Bone: marrow area | 0.5 | 1.0 | 1.3 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 0.9 | 1.2 | 1.0 | 1.0 | -0.9 |
| Bone: post-yield work | 0.5 | 0.6 | 0.8 | 0.9 | 0.8 | 0.8 | 0.8 | 0.8 | 0.7 | 0.9 | 0.8 | 0.8 | -0.7 |
| Time to tail flick, test, before self-admin | 0.5 | 0.5 | 0.8 | 0.7 | 0.7 | 0.9 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 | -0.6 |
| Vertical activity count, locomotor time 2 | 0.5 | 0.5 | 1.1 | -0.5 | -0.7 | -0.8 | -0.7 | -0.7 | -1.1 | -0.3 | -0.8 | -0.6 | 0.9 |
| Seeking ratio, punishment vs. effort | 0.5 | 0.7 | 1.9 | 0.7 | 0.7 | 0.8 | 0.7 | 0.7 | 1.4 | 0.5 | 0.8 | 0.7 | -1.0 |
| Latency to leave start box in cocaine runway | 0.5 | 0.6 | 0.8 | 0.7 | 0.8 | 0.5 | 0.9 | 0.9 | 0.6 | 0.8 | 0.8 | 0.8 | -0.6 |
| Na content in liver | 0.5 | 0.6 | 0.7 | 0.7 | 0.8 | 0.9 | 0.8 | 0.8 | 0.5 | 0.7 | 0.7 | 0.8 | -0.7 |
| BMI with tail | 0.4 | 1.3 | 1.6 | -1.3 | -1.1 | -1.2 | -0.9 | -1.0 | -1.2 | -1.2 | -1.1 | -1.2 | 1.3 |
| Social time | 0.4 | 0.5 | 2.1 | -0.5 | -0.4 | -0.6 | -0.6 | -0.6 | -1.5 | -0.2 | -0.7 | -0.4 | 0.7 |
| Pavlov. Cond. magazine entry latency | 0.4 | 0.5 | 0.7 | 0.6 | 0.7 | 0.8 | 0.7 | 0.7 | 0.3 | 0.7 | 0.6 | 0.7 | -0.8 |
| Intermittent access total locomotion | 0.4 | 0.4 | 0.7 | 0.7 | 0.7 | 0.7 | 0.5 | 0.5 | 0.3 | 0.8 | 0.6 | 0.8 | -0.8 |
| Cocaine induced anxiety | 0.4 | 0.5 | 0.9 | 0.6 | 0.8 | 0.9 | 0.8 | 0.8 | 0.2 | 0.7 | 0.7 | 0.8 | -0.7 |
| Locomotion distance, session 8 | 0.4 | 0.5 | 0.7 | 0.6 | 0.7 | 0.8 | 0.8 | 0.8 | 0.7 | 0.8 | 0.7 | 0.8 | -0.7 |
| Bone: cortical apparent density | 0.4 | 0.5 | 0.8 | 0.6 | 0.6 | 0.7 | 0.7 | 0.7 | 0.9 | 0.6 | 0.7 | 0.7 | -0.8 |
| Bone: cortical area | 0.4 | 0.5 | 0.7 | 0.6 | 0.7 | 0.8 | 0.8 | 0.8 | 0.7 | 0.7 | 0.7 | 0.7 | -0.7 |
| Delta time in open arm before/after self-admin | 0.4 | 0.3 | 0.7 | 0.6 | 0.6 | 0.6 | 0.5 | 0.6 | 0.8 | 0.5 | 0.6 | 0.6 | -0.6 |
| Extinction: sum of active levers before priming | 0.4 | 0.4 | 0.7 | 0.6 | 0.5 | 0.6 | 0.6 | 0.5 | 0.9 | 0.6 | 0.7 | 0.6 | -0.7 |
| Active lever presses in extinction session 6 | 0.4 | 0.4 | 1.1 | 0.9 | 0.7 | 0.5 | 0.6 | 0.6 | 0.2 | 1.0 | 0.5 | 0.8 | -0.3 |
| Time in closed arm before self-admin | 0.4 | 0.5 | 0.8 | -0.5 | -0.7 | -0.6 | -0.9 | -0.8 | -0.8 | -0.4 | -0.7 | -0.5 | 0.8 |
| Delta time to tail flick, test, before/after SA | 0.4 | 0.4 | 0.8 | 0.6 | 0.6 | 0.7 | 0.6 | 0.6 | 0.6 | 0.5 | 0.6 | 0.6 | -0.9 |
| Food consumed during 24 hour testing period | 0.3 | 0.3 | 0.4 | 0.4 | 0.6 | 0.6 | 0.6 | 0.6 | 0.3 | 0.6 | 0.6 | 0.6 | -0.7 |
| Indifference point 0 sec | 0.3 | 0.6 | 0.7 | -0.6 | -0.8 | -0.8 | -0.7 | -0.7 | -0.8 | -0.7 | -0.8 | -0.8 | 0.8 |
| Std. dev. reaction times | 0.3 | 0.4 | 0.5 | -0.6 | -0.7 | -0.7 | -0.7 | -0.7 | -0.7 | -0.5 | -0.7 | -0.6 | 0.5 |
| Social response proportion | 0.3 | 0.3 | 0.7 | -0.4 | -0.5 | -0.7 | -0.5 | -0.5 | -0.8 | -0.3 | -0.6 | -0.4 | 0.5 |
| Conditioned locomotion | 0.3 | 0.3 | 1.3 | 0.8 | 0.5 | 0.1 | 0.3 | 0.4 | -0.6 | 1.1 | 0.2 | 0.7 | -0.0 |
| Stereotopy head waving duration, day 7 | 0.3 | 0.4 | 0.5 | 0.7 | 0.6 | 0.5 | 0.6 | 0.6 | 0.6 | 0.7 | 0.6 | 0.6 | -0.7 |
| Locomotion velocity, session 8 | 0.3 | 0.3 | 0.7 | 0.6 | 0.6 | 0.5 | 0.5 | 0.5 | -0.0 | 0.8 | 0.4 | 0.7 | -0.5 |
| Bone: cortical tissue density | 0.3 | 0.4 | 0.6 | 0.5 | 0.5 | 0.6 | 0.5 | 0.5 | 0.8 | 0.5 | 0.6 | 0.6 | -0.7 |
| Delta ambulatory time before/after self-admin | 0.3 | 0.3 | 0.5 | -0.6 | -0.4 | -0.6 | -0.3 | -0.3 | -0.7 | -0.5 | -0.5 | -0.5 | 0.7 |
| Delay disc. indifference point, 16s delay | 0.3 | 0.3 | 1.4 | 0.3 | 0.2 | 0.3 | 0.3 | 0.3 | 1.2 | 0.3 | 0.5 | 0.4 | -0.6 |
| Delay discount exponential model param | 0.3 | 0.3 | 1.8 | -0.5 | -0.2 | -0.2 | -0.2 | -0.2 | -1.3 | -0.4 | -0.5 | -0.4 | 0.6 |
| Delay discount hyperbolic model param | 0.3 | 0.3 | 1.6 | -0.5 | -0.3 | -0.3 | -0.3 | -0.3 | -1.3 | -0.4 | -0.5 | -0.4 | 0.6 |
| Fecal boli incidents, locomotor time 1 | 0.3 | 0.3 | 0.7 | 0.5 | 0.5 | 0.5 | 0.6 | 0.6 | 0.8 | 0.4 | 0.6 | 0.5 | -0.4 |
| Se content in liver | 0.3 | 0.3 | 0.8 | -0.5 | -0.5 | -0.5 | -0.6 | -0.6 | -0.9 | -0.3 | -0.6 | -0.5 | 0.6 |
| BMI without tail | 0.2 | 0.4 | 0.9 | -0.6 | -0.5 | -0.8 | -0.6 | -0.6 | -0.9 | -0.4 | -0.6 | -0.5 | 0.8 |
| Glucose | 0.2 | 0.3 | 0.5 | -0.6 | -0.5 | -0.4 | -0.5 | -0.5 | -0.7 | -0.6 | -0.6 | -0.5 | 0.5 |
| Delay discounting total patch changes 0 sec | 0.2 | 0.4 | 0.5 | -0.5 | -0.7 | -0.7 | -0.6 | -0.6 | -0.6 | -0.6 | -0.7 | -0.7 | 0.6 |
| Locomotor activity | 0.2 | 0.4 | 0.6 | -0.6 | -0.7 | -0.6 | -0.8 | -0.8 | 0.0 | -0.6 | -0.6 | -0.6 | 0.4 |
| Reaction time num false alarms AUC | 0.2 | 0.2 | 0.9 | 0.1 | 0.2 | 0.5 | 0.3 | 0.2 | 0.9 | 0.1 | 0.4 | 0.2 | -0.8 |
| Reaction time premature initiation rate | 0.2 | 0.3 | 0.4 | -0.5 | -0.5 | -0.4 | -0.6 | -0.6 | -0.3 | -0.5 | -0.5 | -0.5 | 0.5 |
| Pavlov. Cond. magazine entry number | 0.2 | 0.2 | 0.3 | -0.4 | -0.5 | -0.5 | -0.5 | -0.5 | -0.1 | -0.5 | -0.4 | -0.5 | 0.5 |
| Intermittent access intake day 1-15 change | 0.2 | 0.2 | 0.4 | 0.3 | 0.6 | 0.3 | 0.6 | 0.5 | -0.1 | 0.5 | 0.4 | 0.6 | -0.3 |
| Intermittent access intake escalation 2 | 0.2 | 0.2 | 0.8 | -0.6 | -0.1 | -0.1 | -0.1 | -0.1 | -0.9 | -0.5 | -0.3 | -0.2 | 0.3 |
| Intermitt. access day 1 inactive lever presses | 0.2 | 0.3 | 0.8 | 0.2 | 0.5 | 0.9 | 0.6 | 0.6 | -0.1 | 0.4 | 0.4 | 0.4 | -0.6 |
| Intermittent access standard deviation | 0.2 | 0.2 | 0.5 | 0.5 | 0.6 | 0.7 | 0.4 | 0.4 | 0.1 | 0.5 | 0.4 | 0.6 | -0.4 |
| Incentive Sensitization - Breakpoint | 0.2 | 0.2 | 0.5 | -0.5 | -0.3 | -0.2 | -0.3 | -0.4 | -0.7 | -0.4 | -0.4 | -0.3 | 0.4 |
| Locomotion velocity, session 2 | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | -0.5 | -0.5 | -0.5 | -0.4 | -0.5 | -0.5 | -0.5 | 0.4 |
| Degree of sensitization stereotypy | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | -0.5 | -0.5 | -0.5 | -0.3 | -0.5 | -0.4 | -0.5 | 0.4 |
| Condit. Reinf. active responses | 0.2 | 0.2 | 0.5 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.7 | 0.3 | 0.5 | 0.4 | -0.5 |
| Total locomotion distance, hab. session 1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.3 | 0.7 | 0.5 | 0.6 | -0.5 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.6 | 0.5 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | -0.6 |
| Bone: endosteal perimeter | 0.2 | 0.3 | 0.4 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.5 | 0.7 | 0.6 | 0.5 | -0.5 |
| Bone: final force | 0.2 | 0.3 | 0.4 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.4 | 0.7 | 0.5 | 0.5 | -0.4 |
| Bone: final moment | 0.2 | 0.3 | 0.5 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 | 0.5 | 0.7 | 0.5 | 0.6 | -0.4 |
| Bone: periosteal perimeter | 0.2 | 0.4 | 0.4 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | -0.5 |
| Bone: trabecular tissue density | 0.2 | 0.3 | 0.3 | 0.5 | 0.6 | 0.5 | 0.5 | 0.5 | 0.4 | 0.6 | 0.5 | 0.6 | -0.6 |
| Diff in mean of infusions in LGA sessions | 0.2 | 0.3 | 0.4 | 0.6 | 0.5 | 0.4 | 0.5 | 0.4 | 0.4 | 0.7 | 0.5 | 0.6 | -0.6 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | -0.5 | -0.5 | -0.5 | -0.2 | -0.5 | -0.5 | -0.5 | 0.4 |
| Delay disc. indifference point, 8s delay | 0.2 | 0.2 | 1.2 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 1.1 | 0.3 | 0.3 | 0.2 | -0.4 |
| Time >=10cm from walls, locomotor time 2 | 0.2 | 0.2 | 0.6 | 0.6 | 0.4 | 0.3 | 0.3 | 0.3 | 0.1 | 0.8 | 0.3 | 0.6 | -0.5 |
| Tail length | 0.1 | 0.4 | 0.7 | -0.3 | -0.5 | -0.8 | -0.7 | -0.6 | -0.8 | -0.2 | -0.6 | -0.4 | 0.7 |
| Number of licking bursts | 0.1 | 0.1 | 0.3 | 0.2 | 0.2 | 0.3 | 0.3 | 0.2 | 0.6 | 0.2 | 0.3 | 0.2 | -0.5 |
| Mean num. licks in bursts | 0.1 | 0.1 | 0.3 | 0.5 | 0.4 | 0.4 | 0.4 | 0.4 | 0.2 | 0.5 | 0.4 | 0.4 | -0.2 |
| Locomotor testing distance | 0.1 | 0.1 | 0.7 | 0.4 | 0.2 | 0.3 | 0.2 | 0.2 | 0.8 | 0.2 | 0.4 | 0.3 | -0.4 |
| Reaction time num false alarms | 0.1 | 0.1 | 0.5 | 0.1 | 0.1 | 0.4 | 0.2 | 0.2 | 0.7 | -0.0 | 0.3 | 0.1 | -0.6 |
| Reaction time omissions | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.4 | -0.5 |
| Reaction time false alarm rate | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | 0.0 | -0.3 | -0.3 | 0.3 | -0.4 | -0.1 | -0.3 | -0.2 |
| Intermittent access intake escalation | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | 0.1 | 0.4 | 0.3 | -0.4 | 0.3 | 0.1 | 0.4 | -0.1 |
| Intermitt. access escalation Index | 0.1 | 0.1 | 0.5 | -0.4 | -0.2 | -0.2 | -0.1 | -0.1 | -0.7 | -0.4 | -0.3 | -0.3 | 0.4 |
| Incentive Sensitization - Responses | 0.1 | 0.1 | 0.2 | -0.3 | -0.1 | -0.0 | -0.2 | -0.2 | -0.5 | -0.2 | -0.2 | -0.2 | 0.2 |
| Progressive ratio test 2 active lever presses | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.4 | 0.3 | 0.2 | -0.3 | 0.5 | 0.2 | 0.4 | -0.3 |
| Progressive ratio test 2 breakpoint | 0.1 | 0.2 | 0.3 | 0.4 | 0.4 | 0.5 | 0.4 | 0.3 | -0.2 | 0.6 | 0.2 | 0.5 | -0.3 |
| Stereotopy head waving duration, day 3 | 0.1 | 0.1 | 0.2 | 0.5 | 0.4 | 0.3 | 0.3 | 0.3 | 0.3 | 0.5 | 0.3 | 0.4 | -0.3 |
| Locomotion distance, session 7 | 0.1 | 0.1 | 0.2 | 0.2 | 0.4 | 0.4 | 0.4 | 0.4 | 0.0 | 0.4 | 0.2 | 0.4 | -0.3 |
| Total zone transitions, hab. session 1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | 0.4 | -0.4 |
| Total zone transitions, hab. session 2 | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.5 | 0.4 | 0.4 | 0.4 | -0.4 |
| Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.1 | 0.2 | 0.2 | 0.3 | 0.2 | 0.2 | 0.3 | 0.1 | 0.2 | 0.2 | -0.3 |
| Bone: maximum moment | 0.1 | 0.1 | 0.2 | 0.3 | 0.3 | 0.3 | 0.4 | 0.4 | 0.2 | 0.4 | 0.3 | 0.3 | -0.2 |
| Bone: minimum diameter | 0.1 | 0.1 | 0.2 | -0.3 | -0.3 | -0.3 | -0.3 | -0.3 | -0.5 | -0.1 | -0.3 | -0.3 | 0.5 |
| Time in open arm before self-admin | 0.1 | 0.1 | 0.3 | -0.2 | -0.0 | 0.1 | 0.2 | 0.0 | 0.4 | -0.4 | 0.2 | -0.1 | -0.5 |
| Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.2 | -0.2 | -0.3 | -0.1 | -0.4 | -0.4 | -0.3 | -0.2 | -0.3 | -0.2 | -0.0 |
| Ambulatory time before self-admin | 0.1 | 0.1 | 0.3 | 0.2 | 0.3 | 0.3 | 0.4 | 0.3 | 0.6 | 0.2 | 0.4 | 0.3 | -0.3 |
| Area under the delay curve | 0.1 | 0.1 | 1.1 | 0.2 | -0.1 | -0.1 | -0.1 | -0.1 | 1.1 | 0.1 | 0.2 | 0.1 | -0.3 |
| Time >=10cm from walls, locomotor time 1 | 0.1 | 0.1 | 0.2 | -0.1 | -0.4 | -0.5 | -0.4 | -0.4 | 0.3 | -0.1 | -0.2 | -0.4 | 0.3 |
| Rest time, locomotor task time 1 | 0.1 | 0.1 | 0.1 | 0.3 | 0.3 | 0.2 | 0.2 | 0.2 | 0.1 | 0.3 | 0.2 | 0.3 | -0.3 |
| Bouts of movement, locomotor time 2 | 0.1 | 0.1 | 0.3 | -0.4 | -0.3 | -0.4 | -0.3 | -0.3 | -0.2 | -0.2 | -0.3 | -0.2 | 0.5 |
| Progressive ratio | 0.1 | 0.1 | 0.4 | 0.3 | 0.2 | 0.1 | 0.3 | 0.3 | -0.6 | 0.5 | 0.0 | 0.3 | -0.1 |
| Run reversals in cocaine runway, females | 0.1 | 0.1 | 0.3 | -0.4 | -0.4 | -0.2 | -0.4 | -0.4 | 0.2 | -0.5 | -0.3 | -0.4 | 0.2 |
| Run reversals in cocaine runway, males | 0.1 | 0.1 | 0.4 | 0.4 | 0.2 | 0.2 | 0.2 | 0.2 | 0.7 | 0.2 | 0.4 | 0.2 | -0.2 |
| Mg content in liver | 0.1 | 0.1 | 0.3 | -0.4 | -0.3 | -0.3 | -0.3 | -0.3 | -0.5 | -0.4 | -0.4 | -0.3 | 0.3 |
| Sr content in liver | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | -0.3 | -0.3 | -0.3 | -0.1 | -0.4 | -0.3 | -0.3 | 0.3 |
| Left kidney weight | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | 0.0 | -0.2 | -0.2 | 0.0 | -0.2 | -0.1 | -0.2 | 0.1 |
| Std. dev. time between licks in bursts | 0.0 | 0.0 | 0.1 | -0.3 | -0.2 | -0.2 | -0.2 | -0.2 | -0.2 | -0.2 | -0.2 | -0.2 | 0.3 |
| Indifference point function ln k | 0.0 | 0.0 | 0.0 | -0.0 | -0.1 | -0.1 | -0.2 | -0.1 | -0.1 | 0.0 | -0.1 | -0.1 | 0.1 |
| Indifference point function log k | 0.0 | 0.0 | 0.0 | -0.0 | -0.1 | -0.1 | -0.2 | -0.1 | -0.1 | 0.0 | -0.1 | -0.1 | 0.1 |
| Delay discounting total patch changes 18 sec | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | -0.2 | 0.1 | 0.1 | -0.3 | -0.0 | -0.1 | -0.0 | 0.1 |
| Delay discounting total patch changes 6 sec | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.3 | -0.1 | -0.2 | -0.3 | -0.2 | -0.2 | -0.2 | 0.2 |
| Delay discounting time to switch 0 sec | 0.0 | 0.1 | 0.2 | -0.2 | -0.2 | -0.1 | -0.3 | -0.3 | 0.4 | -0.3 | -0.1 | -0.2 | 0.2 |
| Delay discounting water rate 0 sec | 0.0 | 0.1 | 0.2 | 0.3 | 0.2 | -0.0 | 0.3 | 0.3 | -0.5 | 0.5 | 0.0 | 0.3 | -0.1 |
| Reaction time mean minus median | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | -0.1 | -0.1 | -0.1 | 0.1 | -0.1 | -0.0 | -0.1 |
| Reaction time mean minus median AUC | 0.0 | 0.1 | 0.1 | -0.2 | -0.3 | -0.3 | -0.3 | -0.3 | -0.2 | -0.3 | -0.3 | -0.2 | -0.0 |
| Reaction time premature initiations | 0.0 | 0.0 | 0.0 | 0.0 | -0.0 | 0.1 | -0.0 | 0.0 | 0.2 | -0.0 | 0.0 | 0.0 | -0.0 |
| Social responses | 0.0 | 0.1 | 0.4 | -0.1 | -0.1 | -0.2 | -0.2 | -0.1 | -0.6 | 0.1 | -0.2 | -0.0 | -0.0 |
| Context. condit. distance diff. score | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | -0.0 | -0.1 | -0.1 | -0.0 | -0.1 | -0.1 | -0.1 | 0.2 |
| Locomotion velocity, session 1 | 0.0 | 0.0 | 0.1 | -0.2 | 0.0 | 0.1 | 0.0 | 0.0 | -0.3 | -0.1 | -0.1 | -0.0 | -0.0 |
| Locomotion distance, session 2 | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | 0.1 | 0.1 | 0.1 | -0.1 | 0.1 | 0.1 | 0.1 | -0.2 |
| Stereotopy head waving bouts, day 7 | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | -0.1 | -0.1 | -0.1 | -0.2 | -0.1 | -0.1 | 0.1 |
| Incentive salience index mean | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.1 | 0.1 | 0.1 | 0.3 | -0.0 | 0.1 | 0.1 | -0.1 |
| Time in familiar zone, hab. session 2 | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | 0.2 | 0.2 | -0.1 | 0.1 | 0.1 | 0.1 | -0.1 |
| Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.1 | 0.2 | 0.2 | 0.1 | -0.3 |
| Bone: cortical thickness | 0.0 | 0.0 | 0.1 | -0.3 | -0.2 | -0.1 | -0.0 | -0.1 | -0.1 | -0.2 | -0.1 | -0.2 | 0.2 |
| Bone: maximum force | 0.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.3 | 0.3 | 0.1 | 0.3 | 0.2 | 0.2 | -0.1 |
| Bone: stiffness | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | -0.1 | -0.1 | -0.1 | -0.1 | 0.0 | -0.1 | -0.0 | 0.2 |
| Distance traveled before self-admin | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | 0.1 | 0.1 | 0.1 | -0.0 |
| Delta time in closed arm before/after self-admin | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | -0.1 | -0.2 | -0.3 | -0.1 | -0.2 | -0.2 | 0.4 |
| Delta time to tail flick, vehicle, before/after SA | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | -0.1 | -0.2 | -0.1 | -0.2 | 0.1 | -0.1 | -0.0 | 0.3 |
| Delay disc. indifference point, 4s delay | 0.0 | 0.0 | 0.1 | -0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.4 | 0.0 | 0.1 | 0.1 | -0.2 |
| Total resting periods, locomotor time 2 | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 | 0.0 | 0.1 | 0.0 | 0.1 | 0.2 |
| Weight adjusted by age | 0.0 | 0.0 | 0.2 | 0.2 | 0.1 | 0.3 | 0.1 | 0.1 | -0.4 | 0.2 | -0.0 | 0.1 | -0.1 |
| Seeking ratio, delayed vs. immediate footshock | 0.0 | 0.0 | 0.3 | -0.1 | 0.1 | 0.0 | 0.0 | 0.1 | -0.5 | 0.0 | -0.1 | 0.0 | 0.3 |
| Cd content in liver | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0.1 | 0.1 | 0.1 | 0.0 |
| Cu content in liver | 0.0 | 0.0 | 0.1 | 0.3 | 0.2 | 0.2 | 0.1 | 0.2 | 0.2 | 0.3 | 0.2 | 0.2 | -0.1 |
| Fe content in liver | 0.0 | 0.0 | 0.1 | -0.0 | -0.1 | -0.1 | -0.1 | -0.1 | -0.3 | -0.0 | -0.1 | -0.1 | 0.2 |
| K content in liver | 0.0 | 0.0 | 0.1 | -0.3 | -0.1 | -0.1 | -0.1 | -0.1 | -0.3 | -0.2 | -0.2 | -0.1 | 0.2 |
| Rb content in liver | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | -0.0 | -0.1 | -0.1 | -0.1 | -0.0 | -0.1 | -0.0 | 0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.