Hub : Genes

Slc4a1ap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000004901	0.04	0.04	4.7e-04	0.03	0.03	0.03	0.03	4.8e-04	5.0e-04	5.6e-04	5.3e-04
2	Brain	gene expression	ENSRNOG00000004901	0.11	0.11	3.9e-06	0.05	0.05	0.05	0.05	3.3e-05	2.2e-05	2.2e-05	2.0e-05
3	PL	mRNA stability	ENSRNOG00000004901	0.03	0.03	7.8e-03	0.02	0.01	0	0.01	2.1e-02	8.3e-02	2.1e-01	5.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	0.4	1.4	1.5	-1.1	-1.2	1.2
BMI without tail	0.2	0.3	0.7	-0.8	-0.4	0.4
Body weight	1.6	6.8	8.0	-2.8	-2.6	2.4
Epididymis fat weight	13.4	31.3	34.4	-5.9	-5.4	5.5
Glucose	0.2	0.3	0.5	-0.7	-0.4	0.5
Heart weight	10.3	14.8	15.4	-3.9	-3.7	3.9
Left kidney weight	0.0	0.0	0.0	0.1	-0.2	0.2
Right kidney weight	1.0	3.0	3.8	-1.2	-1.9	1.9
Tail length	0.1	0.2	0.5	-0.7	-0.2	0.2
Length with tail	1.2	4.4	5.3	-2.3	-2.0	2.0
Length without tail	0.7	1.5	1.7	-1.2	-1.3	1.2
Liver weight, left	1.1	1.8	2.1	-1.5	-1.3	1.3
Liver weight, right	9.3	15.5	16.1	-3.9	-4.0	3.9
Parametrial fat weight	6.1	11.9	13.1	-3.3	-3.6	3.4
Retroperitoneal fat weight	20.7	68.3	71.4	-8.4	-8.1	8.3
Intraocular pressure	5.2	7.3	8.6	-2.2	-2.9	2.9
Extensor digitorum longus weight	4.4	17.8	18.5	4.3	4.1	-4.3
Soleus weight	4.2	12.3	15.3	3.9	3.2	-3.3
Tibialis anterior weight	3.4	11.6	12.9	3.6	3.2	-3.4
Tibia length	2.4	6.8	8.1	-2.8	-2.5	2.5
Number of licking bursts	0.1	0.1	0.3	0.6	-0.1	-0.2
Food consumed during 24 hour testing period	0.2	0.2	0.3	0.5	0.3	-0.6
Times rat made contact with spout	2.1	2.4	3.3	1.8	1.3	-1.6
Mean time between licks in bursts	2.6	3.6	3.7	-1.8	-1.9	1.9
Mean num. licks in bursts	0.1	0.2	0.2	0.3	0.4	-0.4
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.4	-0.5	0.1
Water consumed over 24 hours	1.5	1.8	2.2	1.5	1.0	-1.5
Indifference point 0 sec	0.3	0.4	0.6	-0.8	-0.5	0.7
Indifference point AUC	2.1	2.4	3.3	1.3	1.5	-1.8
Indifference point function ln k	0.0	0.0	0.0	-0.2	-0.0	0.1
Indifference point function log k	0.0	0.0	0.0	-0.2	-0.0	0.1
Delay discounting total patch changes 0 sec	0.2	0.3	0.4	-0.6	-0.4	0.6
Delay discounting total patch changes 12 sec	0.7	1.0	1.1	-1.1	-0.9	1.0
Delay discounting total patch changes 18 sec	0.0	0.0	0.1	-0.3	0.1	-0.1
Delay discounting total patch changes 24 sec	0.8	1.0	1.6	-1.3	-0.9	0.8
Delay discounting total patch changes 6 sec	0.0	0.0	0.1	-0.2	-0.2	0.1
Delay discounting time to switch 0 sec	0.0	0.1	0.1	0.4	-0.1	0.3
Delay discounting water rate 0 sec	0.1	0.1	0.2	-0.4	0.2	-0.4
Delay discounting water rate 12 sec	1.7	2.5	2.8	-1.6	-1.7	1.5
Delay discounting water rate 18 sec	0.6	0.9	1.0	-1.0	-0.9	0.9
Delay discounting water rate 24 sec	1.7	2.4	2.4	-1.5	-1.5	1.6
Delay discounting water rate 6 sec	1.4	2.1	2.2	-1.5	-1.4	1.4
Locomotor activity	0.2	0.3	0.5	-0.1	-0.7	0.5
Locomotor testing distance	0.1	0.2	0.5	0.7	0.3	-0.3
Locomotor testing rearing	1.1	1.7	2.4	1.0	1.5	-1.3
Light reinforcement 1	3.7	6.7	7.9	2.8	2.4	-2.5
Light reinforcement 2	2.8	3.7	4.9	2.2	1.7	-1.8
Reaction time number correct	0.5	0.7	1.0	1.0	0.7	-0.9
Reaction time mean minus median	0.0	0.0	0.0	-0.2	0.2	-0.0
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.3	-0.1	0.3
Reaction time num false alarms	0.1	0.2	0.4	0.7	-0.2	0.1
Reaction time num false alarms AUC	0.2	0.2	0.7	0.8	-0.2	0.0
Reaction time trials correct on left	0.5	0.7	1.0	1.0	0.7	-0.9
Reaction time trials on left	0.6	0.8	1.0	1.0	0.7	-0.9
Reaction time mean	1.4	1.9	2.1	-1.3	-1.4	1.5
Reaction time mean AUC	1.2	1.6	1.9	-1.1	-1.3	1.4
Median of all reaction times	1.6	2.2	2.5	-1.2	-1.6	1.6
Reaction time omissions	0.1	0.1	0.1	0.3	0.3	-0.4
Reaction time false alarm rate	0.2	0.2	0.3	0.2	-0.6	0.5
Reaction time premature initiation rate	0.2	0.2	0.3	-0.5	-0.5	0.5
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.1	-0.1
Std. dev. reaction times	0.3	0.5	0.7	-0.9	-0.5	0.6
Reaction time trials completed	0.6	0.8	1.0	1.0	0.7	-0.9
Reaction time trials AUC	0.7	1.0	1.3	1.1	0.9	-1.0
Social response proportion	0.3	0.3	0.7	-0.8	-0.3	0.2
Social responses	0.1	0.1	0.3	-0.5	-0.1	-0.1
Social time	0.5	0.7	1.9	-1.4	-0.4	0.2
Conditioned locomotion	3.2	3.8	4.1	2.0	1.9	-1.9
Cocaine response after cond. corrected	0.9	1.0	1.7	1.3	0.8	-0.9
Cocaine response after cond. not corrected	1.9	2.1	3.2	1.8	1.2	-1.3
Cocaine response before conditioning	1.1	1.4	1.6	1.0	1.3	-1.2
Saline control response	0.7	1.0	1.3	0.8	1.0	-1.1
Condit. Reinf. active minus inactive responses	4.2	5.2	5.3	2.3	2.3	-2.3
Condit. Reinf. active-inactive response ratio	1.0	1.1	1.2	1.1	1.0	-1.0
Condit. Reinf. active responses	3.6	5.0	5.6	2.2	2.4	-2.2
Condit. Reinf. inactive responses	2.0	2.5	2.8	1.5	1.7	-1.5
Condit. Reinf. lever presses	2.2	3.0	3.2	1.8	1.6	-1.7
Condit. Reinf. lever reinforcers received	3.1	4.4	5.0	2.0	2.2	-2.0
Pavlov. Cond. lever latency	1.9	2.5	2.9	-1.6	-1.5	1.7
Pavlov. Cond. magazine entry latency	0.3	0.3	0.5	0.4	0.6	-0.7
Pavlov. Cond. change in total contacts	0.6	0.9	1.0	1.0	0.8	-1.0
Pavlov. Cond. index score	1.1	1.4	1.9	1.1	1.1	-1.4
Pavlov. Cond. latency score	1.0	1.3	1.8	1.0	1.0	-1.3
Pavlov. Cond. lever contacts	0.9	1.3	1.5	1.2	1.0	-1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.3	0.5
Pavlov. Cond. intertrial magazine entries	3.2	4.2	4.5	-2.0	-2.1	2.1
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.4	0.9	0.9	-1.2
Pavlov. Cond. response bias	1.7	2.4	2.8	1.6	1.4	-1.7
Conditioned reinforcement - actives	1.4	1.4	2.1	0.3	1.4	-1.4
Conditioned reinforcement - inactives	2.5	2.8	3.2	1.4	1.8	-1.8
Conditioned locomotion	0.8	1.0	1.4	-0.6	1.1	-1.2
Intermittent access intake day 1-15 change	0.2	0.2	0.4	-0.2	0.4	-0.6
Intermittent access intake escalation	0.1	0.1	0.2	-0.4	0.2	-0.4
Intermittent access intake escalation 2	0.4	0.4	0.9	-1.0	-0.5	0.3
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	-0.0	0.3	-0.3
Intermitt. access day 15 inactive lever presses	6.9	7.6	9.6	2.1	3.0	-3.1
Intermitt. access escalation Index	0.3	0.3	0.4	-0.7	-0.4	0.5
Intermittent access day 1 total infusions	4.9	5.6	6.0	2.2	2.4	-2.5
Intermittent access day 15 total infusions	2.1	2.3	3.1	1.1	1.6	-1.8
Intermittent access terminal intake (last 3 days)	1.8	1.9	2.8	1.0	1.5	-1.7
Intermittent access total infusions	2.3	2.5	3.4	1.2	1.7	-1.8
Intermittent access day 1 locomotion	2.1	2.1	2.4	1.5	1.4	-1.4
Intermittent access day 15 total locomotion	0.8	0.8	1.4	0.6	0.9	-1.2
Intermittent access total locomotion	0.5	0.5	0.9	0.3	0.7	-1.0
Intermittent access standard deviation	0.2	0.2	0.4	-0.0	0.6	-0.6
Cocaine induced anxiety	0.3	0.3	0.5	0.2	0.6	-0.7
Post-drug Anxiety	1.1	1.2	1.6	-0.9	-1.3	1.2
Baseline Anxiety	1.5	1.6	2.3	-0.7	-1.5	1.5
Lifetime Intake	3.2	3.6	4.6	1.4	2.1	-2.1
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.5	-0.3	0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	-0.7	-0.5	0.4
Progressive ratio test 1 active lever presses	1.7	1.7	2.4	0.6	1.6	-1.5
Progressive ratio test 1 breakpoint	1.5	1.5	2.2	0.6	1.5	-1.4
Progressive ratio test 1 inactive lever presses	3.8	4.1	5.8	1.1	2.4	-2.3
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	-0.2	0.4	-0.5
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.2	0.5	-0.6
Progressive ratio test 2 inactive lever presses	2.0	2.3	3.3	0.8	1.7	-1.8
Total sessions with >9 infusions	2.8	3.0	4.5	1.0	2.1	-1.9
Short access day 1 total inactive lever presses	4.1	4.5	5.2	1.9	2.3	-2.2
Short access day 10 total inactive lever presses	0.7	0.8	0.9	0.9	0.9	-0.9
Short access day 1 total infusions	5.1	5.4	7.5	1.5	2.7	-2.5
Short access day 10 total infusions	4.0	4.4	5.0	1.8	2.2	-2.2
Short access total infusions	3.2	3.5	4.6	1.3	2.1	-2.1
Short access day 1 locomotion	6.9	7.3	9.3	2.1	3.1	-2.9
Short access day 10 total locomotion	0.7	0.8	1.0	0.8	0.8	-1.0
Short access total locomotion	0.6	0.6	0.9	0.4	0.9	-0.9
Compulsive drug intake	0.7	0.7	1.3	-0.0	-0.8	1.1
One hour access (0.3 mA shock)	1.8	2.1	2.6	1.2	1.5	-1.6
One hour access (shock baseline)	2.2	2.6	4.0	1.0	1.7	-2.0
Number of responses in last shaping day	0.7	0.7	1.1	0.2	1.0	-1.0
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	-0.1	0.1
Locomotion velocity, session 1	0.0	0.0	0.1	-0.3	-0.1	0.1
Locomotion distance, session 1	1.7	2.1	2.6	1.6	1.2	-1.6
Locomotion velocity, session 2	0.2	0.3	0.4	-0.4	-0.6	0.5
Locomotion distance, session 2	0.0	0.0	0.0	-0.1	-0.1	-0.1
Locomotion velocity, session 3	0.6	0.7	1.1	0.7	1.0	-0.8
Locomotion distance, session 3	0.8	0.8	0.9	0.9	0.9	-0.9
Stereotopy head waving bouts, day 3	1.9	2.3	2.8	1.3	1.7	-1.5
Stereotopy head waving duration, day 3	0.2	0.2	0.3	0.3	0.6	-0.5
Locomotion velocity, session 7	0.9	1.0	1.4	0.8	1.0	-1.2
Locomotion distance, session 7	0.0	0.1	0.2	-0.1	0.0	-0.4
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.0	-0.1	0.2
Stereotopy head waving duration, day 7	0.4	0.5	0.7	0.6	0.8	-0.7
Locomotion velocity, session 8	0.3	0.3	0.6	0.0	0.6	-0.8
Locomotion distance, session 8	0.2	0.3	0.6	0.5	0.4	-0.7
Degree of sensitization distance	0.9	0.9	1.1	-1.0	-1.0	0.7
Degree of sensitization stereotypy	0.1	0.2	0.2	-0.2	-0.4	0.5
Condit. Reinf. active minus inactive responses	0.6	0.6	0.8	-0.6	-0.8	0.9
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.1	-0.6	-0.7	1.0
Condit. Reinf. active responses	0.2	0.2	0.5	0.7	0.2	-0.4
Condit. Reinf. inactive responses	1.6	1.9	2.4	1.5	1.0	-1.5
Incentive salience index mean	0.0	0.0	0.1	0.3	0.1	-0.0
Condit. Reinf. lever presses	0.5	0.7	1.2	1.1	0.7	-0.7
Time in familiar zone, hab. session 1	0.7	0.7	1.0	-1.0	-0.8	0.7
Time in novel zone, hab. session 1	0.6	0.6	0.7	-0.7	-0.7	0.8
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.4	0.1	-0.5
Total locomotion distance, hab. session 1	0.2	0.2	0.5	0.3	0.3	-0.7
Locomotion velocity, hab. session 1	1.0	1.4	1.9	1.2	0.9	-1.4
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.0	0.1	-0.1
Time in novel zone, hab. session 2	0.5	0.5	0.6	-0.6	-0.7	0.8
Total zone transitions, hab. session 2	0.1	0.2	0.2	0.5	0.2	-0.5
Total locomotion distance, hab. session 2	0.2	0.3	0.5	0.5	0.3	-0.7
Locomotion velocity, hab. session 2	0.4	0.6	0.8	0.8	0.6	-0.9
Novel to familiar place preference ratio	1.0	1.1	1.4	-0.8	-1.1	1.2
Novelty place preference	1.7	1.8	2.1	-1.1	-1.4	1.5
Time in novel zone, NPP test	1.9	2.0	2.5	-1.2	-1.4	1.6
Total zone transitions, NPP test	1.4	1.9	2.2	1.4	1.3	-1.5
Total locomotion distance, NPP test	1.8	2.5	2.8	1.5	1.5	-1.7
Locomotion velocity, NPP test	3.1	4.4	4.9	2.1	1.9	-2.2
Pavlov. Cond. lever latency	1.5	1.9	2.0	-1.4	-1.4	1.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	0.2	-0.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.2	0.2	-0.1
Pavlov. Cond. index score	0.6	0.8	0.8	0.9	0.9	-0.8
Pavlov. Cond. latency score	0.5	0.7	0.7	0.9	0.8	-0.8
Pavlov. Cond. lever contacts	0.9	1.1	1.3	1.1	1.0	-1.0
Pavlov. Cond. magazine entry number	0.4	0.5	0.5	-0.7	-0.7	0.7
Pavlov. Cond. intertrial magazine entries	1.2	1.5	1.7	1.3	1.1	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	2.0	1.4	1.3	-1.3
Pavlov. Cond. response bias	1.4	1.7	1.7	1.3	1.3	-1.2
Bone: apparent density	5.2	8.6	9.5	3.0	2.7	-3.1
Bone surface	2.5	4.3	5.2	2.1	1.8	-2.3
Bone volume	2.6	4.5	5.5	2.1	1.9	-2.3
Bone: connectivity density	4.9	7.8	8.6	2.9	2.6	-2.8
Bone: cortical apparent density	0.3	0.4	0.6	0.8	0.4	-0.7
Bone: cortical area	0.2	0.4	0.6	0.6	0.4	-0.8
Bone: cortical porosity	1.6	1.8	2.3	1.0	1.5	-1.4
Bone: cortical porosity	1.3	1.4	1.7	1.0	1.3	-1.3
Bone: cortical thickness	0.1	0.1	0.3	-0.1	-0.5	0.2
Bone: cortical thickness	1.4	1.7	1.9	1.3	1.2	-1.4
Bone: cortical tissue density	0.2	0.3	0.4	0.7	0.3	-0.6
Bone: elastic displacement	0.8	1.0	1.1	1.0	1.0	-0.9
Bone: elastic work	1.1	1.4	1.7	1.3	1.1	-1.1
Bone: endosteal estimation	0.4	0.8	1.1	0.8	0.9	-1.0
Bone: endosteal perimeter	0.1	0.3	0.3	0.5	0.4	-0.6
Bone: final force	0.1	0.2	0.3	0.3	0.3	-0.6
Bone: final moment	0.1	0.2	0.4	0.4	0.3	-0.7
Bone: marrow area	0.4	0.9	1.1	0.9	0.9	-1.1
Bone: maximum diameter	0.8	1.4	1.6	1.3	1.0	-1.3
Bone: maximum force	0.0	0.0	0.1	0.0	0.1	-0.3
Bone: maximum moment	0.0	0.1	0.2	0.1	0.2	-0.4
Bone: minimum diameter	0.1	0.2	0.2	-0.5	-0.5	0.2
Bone: periosteal estimation	0.5	1.1	1.4	1.0	0.9	-1.2
Bone: periosteal perimeter	0.2	0.3	0.4	0.6	0.3	-0.6
Bone: post-yield work	0.5	0.7	0.9	0.7	0.9	-1.0
Bone: stiffness	0.0	0.0	0.1	-0.2	-0.2	-0.1
Bone: tissue strength	0.9	0.9	1.1	-0.7	-1.1	1.0
Bone: trabecular number	4.1	6.4	6.8	2.6	2.4	-2.6
Bone: trabecular spacing	3.4	4.4	5.3	-1.9	-2.1	2.3
Bone: trabecular thickness	0.9	1.0	1.6	0.8	0.9	-1.3
Bone: trabecular tissue density	0.2	0.2	0.4	0.3	0.5	-0.6
Breakpoint value in progressive ratio session	1.8	2.0	2.1	1.3	1.4	-1.4
Distance traveled before self-admin	0.0	0.0	0.0	0.2	0.1	-0.1
Distance traveled after self-admin	0.8	0.8	1.1	-0.7	-1.0	1.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.2
Delta time in open arm before/after self-admin	0.3	0.3	0.4	0.5	0.6	-0.6
Diff in mean of infusions in LGA sessions	0.3	0.4	0.5	0.3	0.7	-0.7
Extinction: sum of active levers before priming	0.5	0.5	0.9	0.9	0.5	-0.6
Active lever presses in extinction session 6	0.8	0.8	1.3	0.2	1.0	-1.1
Delta distance traveled before/after self-admin	1.6	1.7	1.7	-1.3	-1.3	1.3
Delta ambulatory time before/after self-admin	0.3	0.3	0.3	-0.6	-0.6	0.5
Time in closed arm before self-admin	0.3	0.4	0.7	-0.9	-0.5	0.4
Time in closed arm after self-admin	1.0	1.1	1.6	-1.3	-0.9	0.9
Time in open arm before self-admin	0.2	0.2	0.3	0.5	-0.3	0.4
Time in open arm after self-admin	1.5	1.6	2.8	1.7	1.0	-1.0
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.5	1.2	0.6	-0.6
Time to tail flick, vehicle, before self-admin	2.2	2.2	2.7	-1.6	-1.3	1.5
Time to tail flick, vehicle, after self-admin	3.6	3.8	5.4	-2.3	-1.7	1.8
Time to tail flick, test, before self-admin	0.6	0.6	0.6	0.7	0.8	-0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	-0.2	0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.3	0.5	0.5	-0.5
Ambulatory time before self-admin	0.1	0.1	0.2	0.5	0.1	-0.3
Ambulatory time after self-admin	0.6	0.7	0.9	-0.6	-0.9	0.9
Total heroin consumption	3.0	3.6	4.1	2.0	1.8	-1.8
Area under the delay curve	0.2	0.2	0.7	0.8	-0.1	-0.2
Delay disc. indifference point, 0s delay	2.9	3.2	4.5	-1.3	-2.1	1.8
Delay disc. indifference point, 16s delay	0.5	0.5	1.3	1.1	0.1	-0.3
Delay disc. indifference point, 2s delay	0.3	0.3	0.5	-0.5	-0.7	0.5
Delay disc. indifference point, 24s delay	2.3	2.3	5.1	2.3	0.8	-1.0
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	0.0	-0.2	-0.1
Delay disc. indifference point, 8s delay	0.3	0.3	0.8	0.9	0.0	-0.3
Delay discount exponential model param	0.4	0.5	1.2	-1.1	-0.2	0.4
Delay discount hyperbolic model param	0.4	0.4	0.9	-1.0	-0.2	0.5
Fecal boli incidents, locomotor time 1	0.3	0.3	0.4	0.6	0.5	-0.4
Change in fecal boli incidents, locomotor task	4.2	4.0	4.2	-1.9	-2.0	2.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.1	-0.3	0.3
Bouts of movement, locomotor time 1	2.6	2.9	3.4	1.8	1.4	-1.9
Total resting periods, locomotor time 1	2.9	3.2	3.8	1.8	1.6	-1.9
Rest time, locomotor task time 1	0.1	0.1	0.2	0.1	0.5	-0.4
Distance moved, locomotor task time 1	1.3	1.5	1.9	-1.0	-1.3	1.4
Vertical activity count, locomotor time 1	0.7	0.7	1.0	-0.5	-1.0	1.0
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.5	-0.0	0.5	-0.7
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.2	-0.5	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.0	-0.2	-0.2
Rest time, locomotor task time 2	1.4	1.6	1.7	1.3	1.2	-1.2
Distance moved, locomotor task time 2	0.9	1.1	1.5	-1.2	-0.9	0.9
Vertical activity count, locomotor time 2	0.5	0.5	1.0	-1.0	-0.5	0.4
Weight adjusted by age	0.1	0.1	0.1	-0.3	0.4	-0.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	-0.6	-0.0	-0.0
Locomotion in novel chamber	0.8	1.0	1.0	-1.0	-1.0	1.0
Locomotion in novel chamber post-restriction	1.8	2.1	2.5	-1.3	-1.4	1.6
Progressive ratio	0.2	0.2	0.3	-0.4	0.4	-0.5
Food seeking constrained by brief footshock	4.0	4.8	6.4	1.5	2.5	-2.4
Seeking ratio, punishment vs. effort	0.5	0.6	1.1	1.0	0.6	-0.5
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.0	-0.4	0.5
Run reversals in cocaine runway, males	0.3	0.3	0.6	0.8	0.4	-0.2
Latency to leave start box in cocaine runway	0.5	0.6	0.6	0.7	0.8	-0.8
Latency to leave start box in cocaine runway, F	0.6	0.6	0.7	0.9	0.7	-0.7
Latency to leave start box in cocaine runway, M	0.7	0.7	1.0	0.4	1.0	-0.9
Cd content in liver	0.0	0.0	0.0	0.0	-0.1	-0.1
Co content in liver	5.4	6.3	6.7	2.6	2.4	-2.5
Cu content in liver	0.1	0.1	0.1	0.2	0.3	-0.3
Fe content in liver	0.1	0.1	0.1	-0.3	0.3	0.1
K content in liver	0.1	0.1	0.2	-0.2	-0.4	0.1
Mg content in liver	0.2	0.2	0.3	-0.4	-0.5	0.3
Mn content in liver	0.7	0.8	1.1	0.7	1.0	-0.8
Na content in liver	0.4	0.5	0.6	0.5	0.7	-0.8
Rb content in liver	0.0	0.0	0.0	-0.1	-0.0	-0.0
Se content in liver	0.3	0.3	0.7	-0.9	-0.4	0.4
Sr content in liver	0.2	0.2	0.3	-0.1	-0.6	0.4
Zn content in liver	1.2	1.3	1.5	-1.2	-1.2	1.0