Hub : Genes

Mpped2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000004863	0.08	0.06	9.6e-08	0.06	0.06	0.05	0.06	4.4e-07	3.6e-07	1.1e-06	3.2e-07
2	BLA	gene expression	ENSRNOG00000004863	0.14	0.08	3.1e-09	0.12	0.14	0.12	0.14	5.7e-07	3.5e-08	3.7e-07	1.1e-07
3	Brain	gene expression	ENSRNOG00000004863	0.13	0.09	8.2e-11	0.09	0.12	0.09	0.11	2.7e-08	4.9e-11	1.6e-08	5.4e-10
4	Brain	mRNA stability	ENSRNOG00000004863	0.26	0.16	9.0e-10	0.11	0.1	0.09	0.1	1.2e-10	6.4e-10	1.8e-08	5.7e-10
5	Eye	gene expression	ENSRNOG00000004863	0.3	0.17	3.0e-03	0.08	0.12	0.1	0.11	2.7e-02	7.2e-03	1.1e-02	1.1e-02
6	NAcc	gene expression	ENSRNOG00000004863	0.09	0.06	4.1e-09	0.08	0.12	0.11	0.11	2.1e-06	5.9e-09	1.0e-08	1.2e-08
7	PL	gene expression	ENSRNOG00000004863	0.06	0.05	8.5e-04	0.04	0.04	0.03	0.04	8.6e-04	3.4e-04	1.3e-03	5.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	0.3	1.0	3.1	1.1	0.0	-0.5	1.5	-0.4	0.0	1.8
BMI without tail	1.0	2.2	4.6	1.9	1.4	1.1	-0.7	1.2	1.4	2.2
Body weight	1.3	5.5	14.2	3.1	2.2	1.5	-0.4	1.7	2.1	3.8
Epididymis fat weight	1.5	3.5	5.4	2.2	1.9	1.6	-1.1	1.8	1.9	2.3
Glucose	0.6	1.0	1.2	0.8	1.0	1.1	-1.1	1.1	1.1	0.6
Heart weight	2.2	3.2	5.2	2.1	1.9	1.6	-0.9	1.6	1.8	2.3
Left kidney weight	1.1	3.0	8.2	2.4	1.6	1.0	-0.2	1.2	1.5	2.9
Right kidney weight	1.9	5.3	11.3	2.9	2.3	1.8	-0.8	1.9	2.3	3.4
Tail length	2.2	6.6	7.2	2.6	2.7	2.5	-2.4	2.6	2.6	2.5
Length with tail	1.6	5.7	8.7	2.7	2.5	2.1	-1.5	2.3	2.4	3.0
Length without tail	0.4	0.9	2.2	1.1	0.9	0.6	0.1	0.7	0.9	1.5
Liver weight, left	1.7	2.7	5.5	2.1	1.6	1.3	-0.8	1.3	1.6	2.3
Liver weight, right	3.7	6.1	8.0	2.6	2.6	2.4	-1.7	2.4	2.6	2.8
Parametrial fat weight	0.2	0.4	0.8	0.7	0.6	0.5	-0.2	0.5	0.6	0.9
Retroperitoneal fat weight	11.4	37.6	54.5	7.1	6.2	5.6	-4.2	5.6	6.3	7.4
Intraocular pressure	1.5	2.1	2.9	-1.2	-1.6	-1.6	1.3	-1.7	-1.6	-1.1
Extensor digitorum longus weight	0.0	0.0	0.1	-0.3	-0.1	-0.0	0.1	-0.1	-0.1	-0.2
Soleus weight	0.2	0.6	0.9	-0.8	-0.8	-0.8	0.9	-0.8	-0.8	-0.5
Tibialis anterior weight	0.9	3.1	4.0	-2.0	-1.8	-1.7	1.5	-1.7	-1.8	-1.8
Tibia length	0.1	0.1	0.4	-0.5	-0.3	-0.3	-0.1	-0.2	-0.4	-0.6
Number of licking bursts	0.2	0.3	0.8	0.8	0.3	0.3	-0.0	0.2	0.4	0.9
Food consumed during 24 hour testing period	1.2	1.5	2.1	1.4	1.2	1.1	-0.7	1.1	1.3	1.5
Times rat made contact with spout	0.6	0.7	1.1	0.5	0.8	1.0	-1.0	1.0	0.8	0.1
Mean time between licks in bursts	0.0	0.0	0.0	-0.2	-0.1	0.0	-0.1	-0.1	-0.1	-0.2
Mean num. licks in bursts	0.2	0.2	0.8	-0.5	0.1	0.3	-0.5	0.4	0.0	-0.9
Std. dev. time between licks in bursts	2.2	2.7	3.0	1.7	1.7	1.6	-1.2	1.7	1.7	1.7
Water consumed over 24 hours	0.0	0.1	0.1	0.3	0.2	0.2	0.1	0.2	0.2	0.3
Indifference point 0 sec	0.0	0.0	0.1	0.3	0.2	0.1	-0.0	0.2	0.2	0.2
Indifference point AUC	1.3	1.5	6.4	-1.7	-0.5	0.2	-0.8	0.1	-0.4	-2.5
Indifference point function ln k	1.4	2.0	6.9	1.8	1.2	0.7	0.3	0.8	1.2	2.6
Indifference point function log k	1.4	2.0	6.9	1.8	1.2	0.7	0.3	0.8	1.2	2.6
Delay discounting total patch changes 0 sec	0.0	0.0	0.1	0.3	0.2	0.1	0.0	0.2	0.2	0.3
Delay discounting total patch changes 12 sec	0.6	0.8	1.8	0.2	0.8	1.1	-1.4	1.1	0.8	-0.4
Delay discounting total patch changes 18 sec	0.2	0.2	0.8	-0.4	-0.1	0.1	-0.7	0.1	-0.1	-0.9
Delay discounting total patch changes 24 sec	1.2	1.5	1.9	1.1	1.3	1.2	-1.4	1.3	1.2	1.0
Delay discounting total patch changes 6 sec	0.5	0.8	1.5	0.2	0.8	1.1	-1.2	1.1	0.8	-0.3
Delay discounting time to switch 0 sec	0.1	0.1	0.4	0.4	-0.1	-0.2	0.2	-0.3	-0.1	0.6
Delay discounting water rate 0 sec	0.2	0.3	0.4	0.4	0.6	0.6	-0.5	0.7	0.6	0.3
Delay discounting water rate 12 sec	1.1	1.6	3.5	1.6	1.2	0.9	-0.5	1.0	1.2	1.9
Delay discounting water rate 18 sec	1.7	2.3	4.1	1.7	1.6	1.3	-0.8	1.4	1.5	2.0
Delay discounting water rate 24 sec	1.8	2.5	3.4	1.6	1.7	1.5	-0.9	1.6	1.7	1.8
Delay discounting water rate 6 sec	0.2	0.3	0.6	0.5	0.6	0.5	-0.2	0.6	0.6	0.8
Locomotor activity	0.3	0.5	0.9	-0.3	-0.8	-0.9	0.9	-0.9	-0.8	-0.1
Locomotor testing distance	0.2	0.4	1.4	0.9	0.3	-0.0	0.3	0.0	0.3	1.2
Locomotor testing rearing	0.2	0.3	0.9	1.0	0.4	0.1	-0.2	0.2	0.3	1.0
Light reinforcement 1	0.7	1.2	1.9	0.9	1.2	1.2	-1.1	1.4	1.2	0.6
Light reinforcement 2	0.9	1.2	1.9	-1.2	-1.1	-1.0	0.9	-0.9	-1.1	-1.4
Reaction time number correct	1.3	1.8	2.1	1.3	1.4	1.4	-1.1	1.4	1.4	1.4
Reaction time mean minus median	0.0	0.0	0.1	-0.0	0.2	0.2	0.2	0.3	0.2	-0.0
Reaction time mean minus median AUC	0.5	0.6	0.9	0.7	0.9	0.9	-0.5	0.9	0.9	0.5
Reaction time num false alarms	0.1	0.1	0.5	-0.1	0.1	0.2	-0.7	0.2	0.1	-0.4
Reaction time num false alarms AUC	0.1	0.1	0.5	-0.4	-0.1	0.0	-0.5	-0.0	-0.2	-0.7
Reaction time trials correct on left	1.3	1.8	2.1	1.3	1.4	1.4	-1.1	1.4	1.4	1.4
Reaction time trials on left	1.2	1.7	2.0	1.2	1.4	1.4	-1.1	1.4	1.4	1.3
Reaction time mean	0.1	0.1	0.2	0.2	0.4	0.4	0.1	0.4	0.4	0.4
Reaction time mean AUC	0.2	0.3	0.4	0.4	0.6	0.6	-0.1	0.6	0.6	0.6
Median of all reaction times	0.1	0.2	0.3	0.4	0.4	0.4	-0.0	0.4	0.5	0.6
Reaction time omissions	0.4	0.5	1.3	-1.1	-0.6	-0.5	0.1	-0.4	-0.6	-1.1
Reaction time false alarm rate	0.5	0.7	1.7	-1.0	-0.8	-0.6	0.0	-0.7	-0.8	-1.3
Reaction time premature initiation rate	0.1	0.2	0.6	-0.4	0.1	0.3	-0.4	0.4	0.1	-0.8
Reaction time premature initiations	0.3	0.4	0.8	0.0	0.6	0.8	-0.8	0.9	0.6	-0.3
Std. dev. reaction times	0.1	0.2	0.3	0.3	0.5	0.5	0.0	0.6	0.5	0.4
Reaction time trials completed	1.2	1.7	2.0	1.2	1.4	1.4	-1.1	1.4	1.4	1.3
Reaction time trials AUC	1.3	1.9	2.2	1.2	1.5	1.5	-1.2	1.5	1.5	1.3
Social response proportion	1.6	1.7	2.6	-1.6	-1.3	-1.3	0.9	-1.1	-1.3	-1.5
Social responses	0.5	0.7	1.5	0.2	0.8	1.0	-1.2	1.0	0.8	-0.1
Social time	4.3	5.6	11.6	-3.1	-2.2	-1.8	1.2	-1.8	-2.2	-3.4
Conditioned locomotion	2.2	2.6	2.8	-1.6	-1.7	-1.6	1.6	-1.6	-1.7	-1.5
Cocaine response after cond. corrected	6.0	6.7	7.4	-2.6	-2.7	-2.6	2.2	-2.6	-2.7	-2.5
Cocaine response after cond. not corrected	1.8	2.1	2.8	-1.7	-1.5	-1.4	1.0	-1.3	-1.5	-1.6
Cocaine response before conditioning	7.9	9.7	10.8	2.8	3.3	3.2	-3.1	3.3	3.3	2.6
Saline control response	1.4	1.9	2.7	1.0	1.5	1.6	-1.6	1.6	1.4	0.6
Condit. Reinf. active minus inactive responses	3.2	3.9	4.9	1.7	2.1	2.1	-2.2	2.2	2.1	1.3
Condit. Reinf. active-inactive response ratio	4.9	5.2	6.0	2.0	2.4	2.4	-2.4	2.5	2.4	1.7
Condit. Reinf. active responses	2.7	3.7	4.3	1.8	2.0	2.0	-2.1	2.1	2.0	1.4
Condit. Reinf. inactive responses	0.4	0.5	0.6	0.8	0.7	0.6	-0.5	0.7	0.7	0.8
Condit. Reinf. lever presses	3.2	4.3	4.8	2.1	2.2	2.1	-2.0	2.2	2.2	1.8
Condit. Reinf. lever reinforcers received	2.7	3.8	4.5	1.8	2.1	2.1	-2.0	2.1	2.0	1.5
Pavlov. Cond. lever latency	4.0	5.5	6.2	-2.3	-2.5	-2.4	2.3	-2.5	-2.5	-2.0
Pavlov. Cond. magazine entry latency	0.6	0.7	0.9	1.0	0.8	0.8	-1.0	0.8	0.8	0.8
Pavlov. Cond. change in total contacts	1.7	2.4	3.1	1.3	1.6	1.8	-1.6	1.8	1.7	0.9
Pavlov. Cond. index score	3.4	4.4	4.8	2.1	2.2	2.2	-2.1	2.2	2.2	1.8
Pavlov. Cond. latency score	3.9	4.9	5.4	2.2	2.3	2.3	-2.2	2.3	2.3	1.9
Pavlov. Cond. lever contacts	4.6	6.5	7.6	2.4	2.7	2.7	-2.5	2.8	2.7	2.1
Pavlov. Cond. magazine entry number	1.5	1.8	2.2	-1.4	-1.3	-1.3	1.5	-1.3	-1.3	-1.2
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.6	0.9	0.5	0.3	0.1	0.2	0.5	1.3
Pavlov. Cond. lever-magazine prob. diff.	3.1	4.1	4.4	2.0	2.1	2.1	-2.0	2.1	2.1	1.7
Pavlov. Cond. response bias	3.4	4.7	5.1	2.2	2.3	2.3	-2.1	2.3	2.3	1.9
Conditioned reinforcement - actives	2.3	2.3	2.6	1.6	1.6	1.5	-0.7	1.6	1.6	1.6
Conditioned reinforcement - inactives	2.9	3.3	3.8	1.9	1.8	1.7	-1.7	1.8	1.9	1.8
Conditioned locomotion	1.9	2.2	2.9	1.7	1.5	1.4	-1.1	1.4	1.5	1.7
Intermittent access intake day 1-15 change	0.2	0.2	0.6	-0.6	-0.0	0.2	-0.2	0.2	-0.0	-0.8
Intermittent access intake escalation	0.2	0.2	0.5	-0.6	0.1	0.3	-0.3	0.3	0.1	-0.7
Intermittent access intake escalation 2	0.3	0.3	1.0	0.1	0.5	0.6	-1.0	0.6	0.5	-0.1
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	-0.0	0.5	0.6	-0.4	0.6	0.5	-0.1
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.6	0.3	0.7	0.7	-0.8	0.7	0.7	0.3
Intermitt. access escalation Index	1.3	1.2	2.5	-1.6	-1.0	-0.7	0.8	-0.8	-0.9	-1.4
Intermittent access day 1 total infusions	0.8	0.9	1.1	1.0	1.0	1.0	-0.3	1.0	1.0	1.0
Intermittent access day 15 total infusions	0.6	0.6	1.2	0.4	0.9	1.1	-0.6	1.1	0.9	0.2
Intermittent access terminal intake (last 3 days)	0.7	0.7	1.3	0.6	1.0	1.1	-0.7	1.1	1.0	0.4
Intermittent access total infusions	0.9	1.0	1.4	0.9	1.1	1.1	-0.4	1.2	1.1	0.9
Intermittent access day 1 locomotion	0.1	0.1	0.4	0.6	0.2	0.1	0.2	0.2	0.2	0.6
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.2	0.3	0.2	-0.1	0.3	0.2	0.2
Intermittent access total locomotion	0.0	0.0	0.1	0.2	0.1	0.0	-0.0	0.1	0.1	0.3
Intermittent access standard deviation	0.9	1.0	1.3	1.0	1.0	1.0	-1.1	1.1	1.0	0.7
Cocaine induced anxiety	0.2	0.2	0.7	0.8	0.2	-0.0	-0.4	-0.1	0.1	0.8
Post-drug Anxiety	3.0	3.4	4.6	2.1	1.8	1.7	-1.9	1.7	1.8	1.8
Baseline Anxiety	0.9	0.9	1.7	0.7	1.1	1.2	-0.7	1.3	1.1	0.4
Lifetime Intake	0.3	0.3	0.6	0.3	0.6	0.7	0.1	0.8	0.6	0.3
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.1	-0.1	-0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.1	-0.2	-0.1	-0.0
Progressive ratio test 1 active lever presses	0.3	0.3	0.7	0.0	0.7	0.8	-0.1	0.8	0.7	0.1
Progressive ratio test 1 breakpoint	0.3	0.3	0.6	0.1	0.6	0.7	-0.2	0.8	0.6	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.3	-0.1	-0.0	0.3	0.1	-0.1	-0.5
Progressive ratio test 2 active lever presses	0.4	0.4	0.6	0.7	0.7	0.7	-0.4	0.7	0.7	0.6
Progressive ratio test 2 breakpoint	1.0	1.2	1.5	1.0	1.2	1.2	-0.9	1.2	1.2	0.9
Progressive ratio test 2 inactive lever presses	1.1	1.3	2.1	1.4	1.1	1.0	-0.7	1.0	1.1	1.4
Total sessions with >9 infusions	0.5	0.5	3.1	-0.3	-0.3	-0.4	1.8	-0.3	-0.3	0.0
Short access day 1 total inactive lever presses	0.1	0.1	0.5	0.6	0.2	-0.0	0.4	0.0	0.2	0.7
Short access day 10 total inactive lever presses	0.9	1.0	1.2	1.0	1.0	1.1	-1.1	0.9	1.0	0.8
Short access day 1 total infusions	0.3	0.3	0.5	0.3	0.6	0.7	-0.0	0.7	0.6	0.4
Short access day 10 total infusions	0.1	0.1	0.6	-0.2	0.1	0.1	0.8	0.3	0.1	-0.1
Short access total infusions	0.2	0.2	1.0	-0.3	-0.1	-0.1	1.0	0.0	-0.1	-0.2
Short access day 1 locomotion	0.0	0.0	0.2	-0.2	-0.1	-0.2	0.4	-0.1	-0.1	0.0
Short access day 10 total locomotion	0.1	0.1	0.2	-0.5	-0.3	-0.4	0.1	-0.3	-0.4	-0.4
Short access total locomotion	0.1	0.1	0.1	0.4	0.3	0.2	-0.4	0.4	0.3	0.3
Compulsive drug intake	1.0	1.0	2.5	-1.3	-0.9	-0.6	-0.3	-0.7	-0.9	-1.6
One hour access (0.3 mA shock)	0.9	1.0	1.7	0.4	1.1	1.2	-1.3	1.3	1.0	0.2
One hour access (shock baseline)	1.8	2.1	2.9	1.3	1.6	1.5	-0.9	1.7	1.6	1.4
Number of responses in last shaping day	1.4	1.4	1.9	0.9	1.3	1.3	-0.8	1.4	1.3	1.1
Context. condit. distance diff. score	1.7	2.1	3.7	1.7	1.4	1.2	-0.9	1.2	1.4	1.9
Locomotion velocity, session 1	1.2	1.3	2.4	-1.5	-1.1	-0.9	0.6	-0.9	-1.1	-1.6
Locomotion distance, session 1	0.3	0.4	1.3	-0.9	-0.5	-0.3	-0.1	-0.3	-0.5	-1.1
Locomotion velocity, session 2	0.2	0.3	0.4	-0.3	-0.5	-0.6	0.7	-0.6	-0.5	-0.1
Locomotion distance, session 2	0.1	0.2	0.8	-0.5	-0.0	0.2	-0.5	0.2	0.0	-0.9
Locomotion velocity, session 3	0.3	0.3	0.7	0.1	0.6	0.7	-0.8	0.7	0.6	-0.0
Locomotion distance, session 3	1.5	1.7	3.6	0.4	1.2	1.5	-1.9	1.5	1.2	-0.1
Stereotopy head waving bouts, day 3	0.3	0.4	0.7	-0.4	-0.6	-0.7	0.8	-0.7	-0.6	-0.0
Stereotopy head waving duration, day 3	0.4	0.5	1.3	0.0	-0.5	-0.8	1.2	-0.8	-0.5	0.6
Locomotion velocity, session 7	0.3	0.3	0.4	0.4	0.6	0.5	-0.6	0.5	0.5	0.4
Locomotion distance, session 7	0.1	0.1	0.3	0.2	0.3	0.3	-0.6	0.4	0.3	-0.1
Stereotopy head waving bouts, day 7	0.5	0.6	1.0	-1.0	-0.7	-0.6	0.3	-0.7	-0.7	-1.0
Stereotopy head waving duration, day 7	0.2	0.3	0.5	-0.7	-0.5	-0.4	0.1	-0.4	-0.5	-0.7
Locomotion velocity, session 8	0.1	0.1	0.2	0.3	0.4	0.4	-0.3	0.4	0.4	0.4
Locomotion distance, session 8	1.2	1.8	2.1	1.2	1.4	1.4	-1.4	1.4	1.4	1.0
Degree of sensitization distance	1.4	1.4	2.8	-0.5	-1.1	-1.4	1.7	-1.4	-1.2	-0.1
Degree of sensitization stereotypy	0.5	0.6	1.5	-1.0	-0.7	-0.5	0.2	-0.6	-0.7	-1.2
Condit. Reinf. active minus inactive responses	3.6	4.0	5.9	1.2	2.1	2.4	-2.1	2.4	2.2	0.8
Condit. Reinf. active-inactive response ratio	5.6	6.0	7.3	2.2	2.6	2.7	-2.2	2.7	2.7	2.0
Condit. Reinf. active responses	2.3	2.8	4.3	0.7	1.7	2.0	-2.0	2.1	1.7	0.3
Condit. Reinf. inactive responses	0.3	0.3	1.1	-0.8	-0.3	-0.1	-0.3	-0.1	-0.4	-1.1
Incentive salience index mean	3.5	4.2	6.4	1.1	2.2	2.5	-2.3	2.5	2.2	0.7
Condit. Reinf. lever presses	1.5	2.0	3.2	0.8	1.5	1.7	-1.6	1.8	1.5	0.5
Time in familiar zone, hab. session 1	0.6	0.6	1.0	-0.8	-0.8	-0.7	0.2	-0.7	-0.8	-1.0
Time in novel zone, hab. session 1	1.1	1.1	1.4	1.0	1.1	1.0	-0.5	1.1	1.1	1.2
Total zone transitions, hab. session 1	1.3	1.8	2.3	1.1	1.4	1.5	-1.4	1.5	1.4	0.9
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.0	0.1	0.2	-0.3	0.2	0.1	-0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.1	0.0	0.1	-0.0	0.1	0.1	-0.1
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.0	-0.2	-0.2	-0.3
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.5	0.4	0.3	-0.0	0.4	0.4	0.7
Total zone transitions, hab. session 2	0.1	0.2	0.3	0.0	0.4	0.6	-0.4	0.6	0.4	-0.2
Total locomotion distance, hab. session 2	0.8	1.1	1.3	-1.1	-1.1	-1.0	1.2	-1.0	-1.0	-1.0
Locomotion velocity, hab. session 2	0.7	1.0	1.2	-1.1	-1.0	-0.9	1.0	-0.9	-0.9	-1.1
Novel to familiar place preference ratio	0.5	0.6	1.4	1.1	0.7	0.5	-0.1	0.5	0.7	1.2
Novelty place preference	0.7	0.7	1.4	1.1	0.8	0.6	-0.3	0.6	0.8	1.2
Time in novel zone, NPP test	0.6	0.6	1.3	1.1	0.8	0.6	-0.2	0.7	0.8	1.1
Total zone transitions, NPP test	0.6	0.9	2.7	-1.3	-0.8	-0.4	0.3	-0.5	-0.7	-1.6
Total locomotion distance, NPP test	0.9	1.2	1.9	-1.3	-1.1	-0.9	0.8	-1.0	-1.1	-1.4
Locomotion velocity, NPP test	0.9	1.3	1.6	-1.3	-1.2	-1.1	0.9	-1.1	-1.2	-1.3
Pavlov. Cond. lever latency	0.3	0.3	0.6	-0.3	-0.6	-0.7	0.7	-0.7	-0.6	-0.1
Pavlov. Cond. magazine entry latency	1.2	1.6	2.1	1.0	1.3	1.4	-1.3	1.4	1.3	0.8
Pavlov. Cond. change in total contacts	1.2	1.3	2.5	0.4	1.1	1.4	-1.6	1.4	1.1	-0.1
Pavlov. Cond. index score	0.6	0.7	1.2	0.4	0.9	1.1	-1.0	1.1	0.9	0.0
Pavlov. Cond. latency score	0.5	0.6	0.9	0.3	0.8	1.0	-1.0	1.0	0.8	-0.0
Pavlov. Cond. lever contacts	0.5	0.6	1.0	0.3	0.8	0.9	-0.9	1.0	0.8	0.1
Pavlov. Cond. magazine entry number	1.9	2.4	3.4	-0.9	-1.6	-1.8	1.8	-1.8	-1.6	-0.6
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.7	0.7	1.2	1.3	-1.2	1.3	1.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.3	0.3	0.9	1.1	-1.1	1.1	0.9	-0.1
Pavlov. Cond. response bias	0.9	1.1	1.8	0.5	1.1	1.3	-1.2	1.3	1.1	0.2
Bone: apparent density	1.1	1.7	2.4	1.6	1.3	1.1	-1.2	1.2	1.3	1.5
Bone surface	1.3	2.3	2.8	1.7	1.6	1.4	-1.4	1.5	1.5	1.6
Bone volume	1.8	3.1	3.9	2.0	1.8	1.6	-1.5	1.7	1.7	2.0
Bone: connectivity density	0.6	1.0	1.6	1.1	1.0	0.9	-1.3	0.9	0.9	0.9
Bone: cortical apparent density	0.2	0.2	0.4	-0.2	0.3	0.5	-0.6	0.5	0.3	-0.5
Bone: cortical area	0.8	1.3	2.7	1.5	1.1	0.9	-0.4	0.9	1.1	1.6
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.3	-0.3	-0.3	-0.4
Bone: cortical porosity	0.2	0.2	0.3	0.4	0.5	0.5	-0.4	0.5	0.5	0.4
Bone: cortical thickness	0.1	0.1	0.4	0.5	0.3	0.2	0.1	0.3	0.3	0.6
Bone: cortical thickness	0.2	0.2	0.5	-0.5	-0.4	-0.3	0.3	-0.3	-0.4	-0.7
Bone: cortical tissue density	0.2	0.3	0.6	-0.2	0.4	0.6	-0.8	0.6	0.4	-0.5
Bone: elastic displacement	0.6	0.7	1.3	-1.1	-0.8	-0.7	0.5	-0.6	-0.8	-1.1
Bone: elastic work	0.0	0.1	0.2	0.3	0.2	0.1	0.2	0.1	0.2	0.4
Bone: endosteal estimation	0.1	0.2	0.4	0.3	-0.1	-0.4	0.7	-0.3	-0.1	0.6
Bone: endosteal perimeter	0.7	1.3	1.9	1.3	1.2	1.1	-0.9	1.0	1.2	1.4
Bone: final force	0.6	1.0	2.0	1.3	1.0	0.7	-0.5	0.8	0.9	1.4
Bone: final moment	0.5	0.8	1.6	1.1	0.9	0.6	-0.4	0.7	0.8	1.3
Bone: marrow area	0.1	0.2	0.4	0.3	-0.1	-0.3	0.6	-0.3	-0.1	0.6
Bone: maximum diameter	0.3	0.6	1.2	1.0	0.7	0.6	-0.3	0.6	0.7	1.1
Bone: maximum force	0.8	1.5	3.5	1.6	1.1	0.8	-0.4	0.9	1.1	1.9
Bone: maximum moment	0.6	1.1	2.7	1.3	1.0	0.7	-0.3	0.8	1.0	1.6
Bone: minimum diameter	1.5	2.9	4.9	2.0	1.7	1.5	-0.9	1.5	1.7	2.2
Bone: periosteal estimation	0.2	0.5	1.7	1.0	0.5	0.3	0.1	0.3	0.5	1.3
Bone: periosteal perimeter	0.8	1.3	2.1	1.4	1.1	1.0	-0.8	1.0	1.2	1.4
Bone: post-yield work	0.2	0.3	0.4	0.6	0.5	0.5	-0.3	0.5	0.5	0.6
Bone: stiffness	0.6	1.0	3.0	1.5	0.8	0.5	-0.0	0.5	0.8	1.7
Bone: tissue strength	1.5	1.5	2.4	-1.1	-1.2	-1.3	1.5	-1.2	-1.2	-0.8
Bone: trabecular number	1.4	2.1	2.6	1.6	1.5	1.3	-1.5	1.4	1.4	1.5
Bone: trabecular spacing	0.4	0.5	0.5	-0.6	-0.7	-0.7	0.6	-0.7	-0.7	-0.7
Bone: trabecular thickness	0.9	1.1	1.3	1.1	1.1	1.0	-1.0	1.0	1.1	1.1
Bone: trabecular tissue density	0.4	0.6	0.7	-0.6	-0.8	-0.8	0.8	-0.7	-0.8	-0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.3	-0.5	0.1	0.3	-0.0	0.3	0.1	-0.5
Distance traveled before self-admin	0.2	0.2	0.4	0.4	0.4	0.5	-0.6	0.4	0.4	0.1
Distance traveled after self-admin	3.0	3.3	3.9	2.0	1.9	1.9	-1.3	1.9	1.9	1.8
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.7	-0.6	-0.5	0.2	-0.5	-0.6	-0.7
Delta time in open arm before/after self-admin	1.4	1.3	2.1	-1.2	-1.1	-1.0	1.4	-1.0	-1.1	-1.1
Diff in mean of infusions in LGA sessions	1.5	1.6	3.2	1.2	1.3	1.2	-1.8	1.3	1.2	0.9
Extinction: sum of active levers before priming	0.7	0.7	1.3	0.4	0.8	1.0	-1.1	1.0	0.8	0.2
Active lever presses in extinction session 6	1.9	1.8	2.0	1.4	1.3	1.4	-1.3	1.3	1.4	1.4
Delta distance traveled before/after self-admin	0.3	0.3	0.4	0.5	0.7	0.6	-0.2	0.7	0.6	0.6
Delta ambulatory time before/after self-admin	0.5	0.6	0.7	0.7	0.8	0.8	-0.4	0.8	0.8	0.8
Time in closed arm before self-admin	1.9	2.2	2.8	1.7	1.5	1.4	-1.0	1.4	1.5	1.7
Time in closed arm after self-admin	1.0	1.0	2.1	1.5	0.9	0.7	-0.7	0.7	0.9	1.4
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	-0.1	0.2	-0.4	0.0	-0.0	-0.5
Time in open arm after self-admin	0.4	0.4	1.3	-1.1	-0.5	-0.2	0.3	-0.3	-0.4	-1.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	0.4	-0.0	-0.2	0.6	-0.2	-0.0	0.6
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.0	0.0	0.2
Time to tail flick, vehicle, after self-admin	1.8	2.0	2.2	1.4	1.4	1.4	-1.4	1.5	1.5	1.2
Time to tail flick, test, before self-admin	0.3	0.3	0.7	-0.1	0.5	0.8	-0.8	0.7	0.6	-0.1
Time to tail flick, test, after self-admin	0.4	0.4	0.8	-0.9	-0.6	-0.6	0.5	-0.5	-0.6	-0.8
Delta time to tail flick, vehicle, before/after SA	2.3	2.3	2.8	1.7	1.5	1.5	-1.2	1.5	1.6	1.5
Delta time to tail flick, test, before/after SA	2.0	1.8	2.6	-1.1	-1.4	-1.6	1.4	-1.5	-1.4	-0.9
Ambulatory time before self-admin	0.4	0.4	0.7	0.7	0.6	0.7	-0.8	0.5	0.6	0.4
Ambulatory time after self-admin	3.5	3.9	4.4	2.1	2.1	2.1	-1.6	2.0	2.1	1.8
Total heroin consumption	0.2	0.3	0.4	-0.7	-0.5	-0.5	0.4	-0.4	-0.5	-0.5
Area under the delay curve	0.4	0.4	1.0	0.3	0.6	0.6	-1.0	0.6	0.6	0.3
Delay disc. indifference point, 0s delay	0.5	0.6	1.2	1.1	0.7	0.6	-0.3	0.7	0.7	0.9
Delay disc. indifference point, 16s delay	0.0	0.0	0.2	-0.1	0.2	0.2	-0.4	0.2	0.1	-0.1
Delay disc. indifference point, 2s delay	0.6	0.6	1.6	1.1	0.7	0.5	-0.2	0.5	0.7	1.3
Delay disc. indifference point, 24s delay	0.6	0.6	0.8	-0.7	-0.8	-0.9	0.2	-0.9	-0.9	-0.6
Delay disc. indifference point, 4s delay	1.1	1.2	2.7	0.5	1.1	1.2	-1.6	1.2	1.1	0.3
Delay disc. indifference point, 8s delay	0.8	0.9	1.5	0.7	1.0	0.9	-1.2	1.0	0.9	0.7
Delay discount exponential model param	0.3	0.3	0.9	-0.2	-0.6	-0.6	1.0	-0.6	-0.5	-0.3
Delay discount hyperbolic model param	0.4	0.4	1.0	-0.4	-0.7	-0.7	1.0	-0.7	-0.6	-0.4
Fecal boli incidents, locomotor time 1	4.6	5.0	6.1	-2.5	-2.3	-2.2	2.0	-2.3	-2.3	-2.0
Change in fecal boli incidents, locomotor task	3.9	3.7	4.3	1.9	2.0	2.0	-1.8	2.1	2.0	1.6
Time >=10cm from walls, locomotor time 1	0.7	0.7	0.9	-0.8	-0.9	-0.9	0.6	-0.9	-0.9	-0.8
Bouts of movement, locomotor time 1	0.8	0.9	1.9	-1.2	-0.9	-0.7	-0.1	-0.8	-0.9	-1.4
Total resting periods, locomotor time 1	1.4	1.6	3.1	-1.6	-1.3	-1.1	0.1	-1.1	-1.3	-1.7
Rest time, locomotor task time 1	1.1	1.2	1.9	-1.3	-1.2	-1.0	0.3	-1.1	-1.1	-1.4
Distance moved, locomotor task time 1	2.5	2.7	3.2	1.7	1.8	1.7	-1.1	1.8	1.8	1.6
Vertical activity count, locomotor time 1	1.6	1.7	2.9	1.7	1.3	1.0	-0.5	1.2	1.3	1.7
Time >=10cm from walls, locomotor time 2	4.4	4.7	6.1	2.5	2.2	2.0	-1.8	2.1	2.2	2.3
Bouts of movement, locomotor time 2	0.4	0.5	1.2	0.7	0.6	0.6	-1.1	0.6	0.6	0.5
Total resting periods, locomotor time 2	0.2	0.2	0.8	0.3	0.4	0.4	-0.9	0.4	0.3	0.0
Rest time, locomotor task time 2	6.1	7.1	9.9	-3.2	-2.7	-2.5	1.8	-2.5	-2.7	-3.1
Distance moved, locomotor task time 2	6.7	7.8	9.0	2.7	3.0	3.0	-2.4	3.0	3.0	2.4
Vertical activity count, locomotor time 2	8.5	9.3	12.5	3.5	3.1	2.8	-2.3	2.9	3.1	3.4
Weight adjusted by age	0.6	0.7	0.8	0.7	0.9	0.8	-0.9	0.8	0.9	0.9
Seeking ratio, delayed vs. immediate footshock	4.2	4.8	5.2	2.2	2.3	2.2	-2.3	2.3	2.2	1.8
Locomotion in novel chamber	1.6	2.0	2.6	1.6	1.3	1.3	-1.5	1.1	1.4	1.6
Locomotion in novel chamber post-restriction	0.2	0.3	0.9	-0.9	-0.3	-0.1	0.0	-0.1	-0.3	-0.9
Progressive ratio	0.9	1.0	2.0	-0.6	-1.0	-1.2	1.4	-1.2	-1.0	-0.2
Food seeking constrained by brief footshock	0.2	0.2	0.6	-0.4	-0.5	-0.5	0.8	-0.5	-0.5	-0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.3	0.2	0.4	-0.4	0.4	0.2	-0.5
Run reversals in cocaine runway, females	1.1	1.1	1.6	1.3	1.1	1.0	-0.9	1.0	1.0	1.1
Run reversals in cocaine runway, males	1.2	1.2	2.2	-1.5	-1.1	-1.0	0.2	-1.0	-1.1	-1.4
Latency to leave start box in cocaine runway	0.2	0.2	0.6	-0.7	-0.3	-0.1	0.2	-0.1	-0.3	-0.8
Latency to leave start box in cocaine runway, F	0.6	0.7	0.9	-1.0	-0.8	-0.7	0.9	-0.6	-0.8	-1.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.5	-0.1	0.3	0.4	-0.7	0.4	0.3	-0.3
Cd content in liver	0.6	0.7	1.6	-0.1	0.6	1.0	-1.3	0.9	0.7	-0.6
Co content in liver	0.9	1.1	3.2	-1.4	-0.9	-0.6	0.1	-0.7	-0.9	-1.8
Cu content in liver	0.8	1.0	1.7	-1.1	-1.0	-0.9	0.4	-1.0	-1.0	-1.3
Fe content in liver	0.3	0.3	0.6	-0.6	-0.6	-0.5	0.4	-0.5	-0.5	-0.8
K content in liver	0.1	0.1	0.2	-0.2	0.0	0.1	-0.5	0.1	0.0	-0.4
Mg content in liver	0.2	0.2	0.7	-0.6	-0.3	-0.1	-0.3	-0.1	-0.3	-0.8
Mn content in liver	0.7	0.8	1.9	-1.2	-0.8	-0.7	0.3	-0.6	-0.8	-1.4
Na content in liver	0.5	0.6	1.0	0.3	0.8	0.9	-1.0	0.9	0.8	0.0
Rb content in liver	0.4	0.5	2.0	-1.0	-0.4	-0.2	-0.3	-0.2	-0.4	-1.4
Se content in liver	1.4	1.7	2.0	-1.1	-1.4	-1.4	1.4	-1.4	-1.3	-1.0
Sr content in liver	0.1	0.1	0.1	0.2	0.3	0.4	-0.3	0.4	0.3	0.2
Zn content in liver	0.5	0.6	1.8	-1.0	-0.6	-0.4	0.1	-0.4	-0.6	-1.3