# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | alternative polyA | ENSRNOT00000006408 | 0.0290 | 0.0211 | 2.7e-03 | 0.012 | 0.016 | 0.008 | 0.011 | 1.3e-02 | 6.4e-03 | 3.9e-02 | 1.9e-02 |
2 | Adipose | alternative polyA | ENSRNOT00000091935 | 0.0309 | 0.0223 | 1.9e-03 | 0.006 | 0.017 | 0.013 | 0.011 | 6.1e-02 | 4.3e-03 | 1.1e-02 | 2.1e-02 |
3 | Adipose | gene expression | ENSRNOG00000004763 | 0.2300 | 0.0930 | 0.0e+00 | 0.156 | 0.142 | 0.181 | 0.181 | 5.0e-17 | 1.7e-15 | 1.3e-19 | 1.1e-19 |
4 | Adipose | isoform ratio | ENSRNOT00000095684 | 0.0800 | 0.0490 | 6.1e-09 | 0.060 | 0.056 | 0.048 | 0.058 | 2.9e-07 | 7.0e-07 | 4.2e-06 | 4.3e-07 |
5 | Adipose | isoform ratio | ENSRNOT00000103247 | 0.2000 | 0.0860 | 0.0e+00 | 0.185 | 0.183 | 0.177 | 0.182 | 4.4e-20 | 6.5e-20 | 3.4e-19 | 9.5e-20 |
6 | BLA | gene expression | ENSRNOG00000004763 | 0.0587 | 0.0431 | 3.4e-03 | 0.023 | 0.003 | 0.009 | -0.004 | 2.1e-02 | 2.0e-01 | 9.6e-02 | 6.0e-01 |
7 | BLA | isoform ratio | ENSRNOT00000095684 | 0.3200 | 0.1800 | 1.1e-14 | 0.190 | 0.161 | 0.212 | 0.124 | 2.0e-10 | 5.6e-09 | 1.4e-11 | 3.7e-07 |
8 | BLA | isoform ratio | ENSRNOT00000103247 | 0.4400 | 0.1500 | 0.0e+00 | 0.384 | 0.210 | 0.380 | 0.160 | 9.6e-22 | 1.8e-11 | 1.6e-21 | 6.1e-09 |
9 | Brain | alternative polyA | ENSRNOT00000006408 | 0.1300 | 0.0700 | 1.0e-14 | 0.159 | 0.143 | 0.146 | 0.148 | 1.3e-14 | 3.5e-13 | 1.7e-13 | 1.3e-13 |
10 | Brain | alternative polyA | ENSRNOT00000091935 | 0.1300 | 0.0710 | 1.3e-14 | 0.159 | 0.142 | 0.145 | 0.148 | 1.5e-14 | 4.0e-13 | 2.1e-13 | 1.4e-13 |
11 | Brain | alternative polyA | ENSRNOT00000006408 | 0.1200 | 0.0710 | 3.7e-12 | 0.133 | 0.117 | 0.120 | 0.125 | 2.8e-12 | 5.4e-11 | 3.1e-11 | 1.3e-11 |
12 | Brain | alternative polyA | ENSRNOT00000091935 | 0.1300 | 0.0740 | 2.4e-12 | 0.136 | 0.119 | 0.121 | 0.126 | 1.3e-12 | 4.2e-11 | 2.7e-11 | 1.1e-11 |
13 | Brain | gene expression | ENSRNOG00000004763 | 0.2000 | 0.1600 | 1.0e-04 | 0.017 | 0.033 | 0.042 | 0.027 | 8.6e-03 | 4.9e-04 | 8.5e-05 | 1.4e-03 |
14 | Brain | isoform ratio | ENSRNOT00000006408 | 0.2365 | 0.1102 | 0.0e+00 | 0.279 | 0.277 | 0.279 | 0.280 | 6.1e-26 | 9.6e-26 | 5.3e-26 | 4.5e-26 |
15 | Brain | isoform ratio | ENSRNOT00000103247 | 0.4141 | 0.1447 | 0.0e+00 | 0.448 | 0.455 | 0.451 | 0.459 | 1.5e-45 | 1.7e-46 | 4.4e-46 | 4.1e-47 |
16 | Brain | intron excision ratio | chr3:116836920:116841431 | 0.0323 | 0.0237 | 1.1e-03 | 0.033 | 0.027 | 0.016 | 0.030 | 4.5e-04 | 1.4e-03 | 1.0e-02 | 8.8e-04 |
17 | IL | isoform ratio | ENSRNOT00000095684 | 0.5850 | 0.1890 | 9.2e-03 | -0.012 | -0.010 | -0.009 | -0.008 | 9.7e-01 | 6.6e-01 | 6.0e-01 | 5.3e-01 |
18 | IL | isoform ratio | ENSRNOT00000103247 | 0.3480 | 0.2210 | 4.7e-04 | 0.115 | 0.111 | 0.124 | 0.128 | 1.1e-03 | 1.3e-03 | 7.0e-04 | 5.6e-04 |
19 | Liver | gene expression | ENSRNOG00000004763 | 0.3400 | 0.1500 | 1.2e-06 | 0.038 | 0.015 | 0.053 | 0.036 | 4.2e-05 | 8.3e-03 | 1.3e-06 | 6.4e-05 |
20 | NAcc | gene expression | ENSRNOG00000004763 | 0.1700 | 0.1300 | 5.1e-05 | 0.019 | 0.028 | 0.031 | 0.015 | 1.3e-02 | 3.3e-03 | 2.3e-03 | 2.4e-02 |
21 | NAcc | isoform ratio | ENSRNOT00000095684 | 0.1245 | 0.0644 | 5.0e-11 | 0.122 | 0.127 | 0.123 | 0.121 | 2.3e-09 | 1.0e-09 | 2.1e-09 | 2.8e-09 |
22 | NAcc | isoform ratio | ENSRNOT00000103247 | 0.2399 | 0.1105 | 0.0e+00 | 0.226 | 0.228 | 0.206 | 0.231 | 8.5e-17 | 5.7e-17 | 2.8e-15 | 3.8e-17 |
23 | NAcc | mRNA stability | ENSRNOG00000004763 | 0.1105 | 0.0844 | 2.8e-05 | 0.063 | 0.049 | 0.054 | 0.051 | 1.7e-05 | 1.4e-04 | 6.7e-05 | 1.1e-04 |
24 | OFC | isoform ratio | ENSRNOT00000103247 | 0.2300 | 0.1200 | 6.6e-04 | 0.100 | 0.081 | 0.050 | 0.071 | 2.4e-03 | 5.7e-03 | 2.5e-02 | 9.4e-03 |
25 | PL | gene expression | ENSRNOG00000004763 | 0.0355 | 0.0285 | 6.4e-03 | 0.014 | 0.014 | 0.005 | 0.010 | 3.0e-02 | 2.9e-02 | 1.2e-01 | 5.1e-02 |
26 | PL | isoform ratio | ENSRNOT00000095684 | 0.1400 | 0.0730 | 2.5e-11 | 0.127 | 0.133 | 0.133 | 0.128 | 6.7e-10 | 2.5e-10 | 2.6e-10 | 6.0e-10 |
27 | PL | isoform ratio | ENSRNOT00000103247 | 0.3800 | 0.1300 | 0.0e+00 | 0.387 | 0.374 | 0.384 | 0.377 | 4.9e-31 | 8.9e-30 | 9.7e-31 | 3.8e-30 |
28 | PL | mRNA stability | ENSRNOG00000004763 | 0.0347 | 0.0275 | 9.4e-03 | 0.025 | 0.011 | 0.009 | 0.014 | 4.7e-03 | 4.7e-02 | 6.0e-02 | 2.6e-02 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Locomotion distance, session 3 | 7.2 | 7.8 | 9.7 | -2.8 | 2.8 | 2.7 | 3.0 | -3.0 | 2.8 | 3.0 | -2.9 | 2.9 | -2.9 | 2.9 | -2.8 | -1.1 | 3.0 | -3.0 | 3.0 | 3.1 | -2.7 | -0.5 | 2.8 | 2.8 | -2.9 | -3.0 | -2.6 | 2.8 | 2.9 | -3.0 | -3.1 |
Cocaine induced anxiety | 6.4 | 7.4 | 10.0 | 3.1 | -3.1 | -3.2 | -2.7 | 2.7 | -2.7 | -2.6 | 2.9 | -3.1 | 3.1 | -3.1 | 2.7 | 0.9 | -2.9 | 2.9 | -3.0 | -2.7 | 2.4 | -0.1 | -2.5 | -2.6 | 2.6 | 2.7 | 2.4 | -2.6 | -2.7 | 2.9 | 3.0 |
Body weight | 5.1 | 21.8 | 27.3 | -4.1 | 4.1 | 3.3 | 4.9 | -4.9 | 4.9 | 4.7 | -4.8 | 4.7 | -4.7 | 4.7 | -4.9 | -3.5 | 5.0 | -4.9 | 4.6 | 5.2 | -4.8 | 1.6 | 4.7 | 5.0 | -5.0 | -5.0 | -5.0 | 4.9 | 5.0 | -5.1 | -5.2 |
Condit. Reinf. active responses | 4.5 | 6.2 | 8.5 | -1.6 | 1.5 | 0.9 | 2.6 | -2.6 | 2.7 | 2.8 | -2.7 | 2.7 | -2.7 | 2.7 | -2.7 | -0.8 | 2.7 | -2.7 | 2.7 | 2.7 | -2.8 | 1.2 | 2.9 | 2.7 | -2.7 | -2.6 | -2.4 | 2.8 | 2.7 | -2.7 | -2.1 |
Progressive ratio | 4.4 | 5.1 | 9.1 | 1.6 | -1.6 | -1.4 | -2.1 | 2.1 | -2.2 | -2.4 | 2.5 | -2.2 | 2.2 | -2.2 | 2.2 | 1.9 | -2.5 | 2.5 | -2.7 | -3.0 | 2.3 | -1.5 | -2.6 | -2.3 | 2.1 | 2.0 | 1.8 | -2.5 | -2.3 | 2.7 | 2.6 |
Saline control response | 4.3 | 5.7 | 9.3 | -1.9 | 1.8 | 1.2 | 2.5 | -2.5 | 2.4 | 2.7 | -2.5 | 2.5 | -2.5 | 2.5 | -2.4 | -0.7 | 2.5 | -2.5 | 2.5 | 2.5 | -2.7 | 0.8 | 2.5 | 2.7 | -2.6 | -2.7 | -3.0 | 2.6 | 2.7 | -2.5 | -2.4 |
Tail length | 4.2 | 12.8 | 16.3 | -3.6 | 3.6 | 3.1 | 3.9 | -3.9 | 3.6 | 3.5 | -3.7 | 3.4 | -3.4 | 3.4 | -3.6 | -2.7 | 4.0 | -3.9 | 3.1 | 3.8 | -3.5 | 0.4 | 3.6 | 3.7 | -3.9 | -3.9 | -3.9 | 3.5 | 3.7 | -3.9 | -4.0 |
Rb content in liver | 4.2 | 5.2 | 8.0 | -1.3 | 1.2 | 0.9 | 2.6 | -2.6 | 2.7 | 2.8 | -2.4 | 2.4 | -2.4 | 2.4 | -2.7 | 1.1 | 2.3 | -2.3 | 2.3 | 2.6 | -2.6 | 0.1 | 2.8 | 2.4 | -2.4 | -2.5 | -2.1 | 2.5 | 2.4 | -2.4 | -2.0 |
Tibia length | 4.1 | 11.5 | 15.3 | -3.9 | 3.9 | 3.9 | 3.5 | -3.5 | 3.2 | 3.5 | -3.5 | 3.4 | -3.4 | 3.4 | -3.2 | 0.1 | 3.6 | -3.6 | 3.3 | 3.2 | -3.0 | -1.9 | 3.4 | 3.5 | -3.6 | -3.7 | -3.6 | 3.2 | 3.5 | -3.7 | -3.4 |
Social responses | 3.9 | 5.0 | 7.0 | -1.9 | 1.8 | 1.2 | 2.7 | -2.7 | 2.5 | 2.5 | -2.6 | 2.2 | -2.2 | 2.2 | -2.5 | 0.4 | 2.4 | -2.4 | 2.2 | 1.5 | -2.6 | 0.1 | 2.5 | 2.6 | -2.6 | -2.6 | -2.6 | 2.4 | 2.5 | -2.5 | -1.4 |
Delay disc. indifference point, 0s delay | 3.9 | 4.3 | 6.5 | 1.3 | -1.3 | -0.9 | -2.2 | 2.2 | -2.3 | -2.4 | 2.1 | -2.1 | 2.1 | -2.1 | 2.3 | 2.3 | -2.1 | 2.2 | -2.0 | -2.6 | 2.2 | -1.1 | -2.3 | -2.0 | 2.1 | 2.2 | 1.8 | -2.2 | -2.0 | 2.2 | 2.4 |
Seeking ratio, punishment vs. effort | 3.8 | 4.7 | 8.9 | -1.0 | 0.9 | 0.5 | 1.9 | -1.9 | 2.0 | 2.5 | -2.3 | 2.3 | -2.3 | 2.3 | -2.0 | -1.7 | 2.4 | -2.3 | 2.6 | 3.0 | -2.4 | 2.3 | 2.6 | 2.3 | -2.0 | -1.9 | -1.9 | 2.6 | 2.3 | -2.5 | -2.3 |
Delay discounting water rate 0 sec | 3.7 | 5.9 | 10.1 | -0.8 | 0.7 | -0.1 | 2.3 | -2.3 | 2.7 | 2.9 | -2.4 | 2.4 | -2.4 | 2.4 | -2.7 | -2.4 | 2.4 | -2.4 | 2.2 | 3.2 | -2.7 | 2.5 | 2.8 | 2.6 | -2.5 | -2.3 | -2.6 | 2.9 | 2.7 | -2.4 | -2.5 |
BMI without tail | 3.5 | 7.3 | 11.5 | -2.8 | 2.8 | 2.7 | 2.7 | -2.7 | 2.6 | 2.7 | -2.8 | 2.9 | -2.9 | 2.9 | -2.6 | -2.1 | 3.0 | -2.9 | 2.5 | 3.2 | -2.4 | 0.2 | 2.7 | 2.7 | -2.7 | -2.7 | -2.7 | 2.7 | 2.8 | -2.9 | -3.4 |
Heart weight | 3.5 | 5.1 | 10.0 | -0.8 | 0.7 | 0.1 | 2.3 | -2.3 | 2.4 | 2.5 | -2.2 | 2.1 | -2.1 | 2.1 | -2.4 | -2.4 | 2.2 | -2.2 | 2.0 | 3.2 | -2.7 | 2.8 | 2.5 | 2.3 | -2.2 | -2.4 | -2.0 | 2.6 | 2.3 | -2.2 | -2.8 |
Length with tail | 3.5 | 12.7 | 18.1 | -2.7 | 2.7 | 1.5 | 4.0 | -4.0 | 3.8 | 3.6 | -3.8 | 3.2 | -3.2 | 3.2 | -3.8 | -3.0 | 3.8 | -3.8 | 3.3 | 3.6 | -4.0 | 1.9 | 3.8 | 4.0 | -4.0 | -4.0 | -4.3 | 3.9 | 3.9 | -3.9 | -3.5 |
Bone: maximum diameter | 3.5 | 6.4 | 8.4 | -1.7 | 1.6 | 0.9 | 2.6 | -2.6 | 2.7 | 2.8 | -2.7 | 2.6 | -2.6 | 2.6 | -2.7 | -1.8 | 2.7 | -2.7 | 2.5 | 2.8 | -2.9 | 1.5 | 2.8 | 2.7 | -2.6 | -2.8 | -2.9 | 2.8 | 2.7 | -2.7 | -2.6 |
Condit. Reinf. lever reinforcers received | 3.3 | 4.7 | 6.4 | -1.3 | 1.2 | 0.6 | 2.2 | -2.2 | 2.3 | 2.5 | -2.3 | 2.3 | -2.3 | 2.3 | -2.3 | -0.9 | 2.4 | -2.4 | 2.4 | 2.5 | -2.5 | 1.3 | 2.5 | 2.4 | -2.3 | -2.3 | -2.2 | 2.5 | 2.4 | -2.4 | -1.9 |
Distance traveled before self-admin | 3.3 | 3.5 | 7.3 | -0.8 | 0.7 | -0.0 | 1.7 | -1.7 | 1.7 | 2.3 | -1.9 | 2.1 | -2.1 | 2.1 | -1.7 | -1.3 | 1.8 | -1.9 | 2.1 | 2.5 | -2.1 | 2.7 | 2.1 | 2.0 | -1.7 | -1.7 | -2.0 | 2.2 | 2.1 | -1.7 | -2.2 |
Pavlov. Cond. response bias | 3.2 | 4.4 | 6.3 | -1.7 | 1.7 | 1.1 | 2.2 | -2.2 | 2.1 | 2.2 | -2.0 | 2.1 | -2.1 | 2.1 | -2.1 | -1.5 | 2.1 | -2.1 | 2.2 | 2.3 | -2.3 | 0.9 | 2.0 | 2.3 | -2.4 | -2.4 | -2.5 | 2.2 | 2.3 | -2.1 | -2.2 |
Short access day 10 total inactive lever presses | 3.2 | 3.6 | 7.5 | 2.7 | -2.7 | -2.7 | -2.1 | 2.1 | -2.2 | -1.5 | 1.9 | -1.7 | 1.7 | -1.7 | 2.2 | -0.6 | -1.8 | 1.8 | -1.4 | -0.5 | 1.4 | 2.0 | -1.6 | -1.8 | 2.1 | 2.0 | 2.1 | -1.3 | -1.8 | 1.9 | 1.2 |
Pavlov. Cond. lever latency | 3.1 | 4.3 | 6.0 | 1.8 | -1.8 | -1.1 | -2.2 | 2.2 | -2.1 | -2.0 | 2.0 | -2.1 | 2.1 | -2.1 | 2.1 | 2.1 | -2.1 | 2.1 | -2.2 | -2.0 | 2.2 | -1.0 | -1.8 | -2.2 | 2.4 | 2.3 | 2.4 | -2.1 | -2.2 | 2.1 | 2.2 |
Total heroin consumption | 3.1 | 3.8 | 5.5 | -1.5 | 1.5 | 0.9 | 1.9 | -1.9 | 1.9 | 2.2 | -2.3 | 2.3 | -2.3 | 2.3 | -1.9 | -0.4 | 2.3 | -2.2 | 2.0 | 1.1 | -2.1 | 0.5 | 2.3 | 2.2 | -1.9 | -2.0 | -2.3 | 2.1 | 2.1 | -2.3 | -1.1 |
Condit. Reinf. active minus inactive responses | 3.0 | 3.7 | 5.1 | -1.0 | 1.0 | 0.4 | 1.9 | -1.9 | 2.0 | 2.0 | -2.0 | 2.0 | -2.0 | 2.0 | -2.0 | -1.6 | 2.1 | -2.1 | 2.1 | 2.2 | -2.2 | 1.6 | 2.2 | 2.0 | -2.1 | -2.0 | -1.8 | 2.2 | 2.0 | -2.1 | -1.8 |
Condit. Reinf. active-inactive response ratio | 2.9 | 3.0 | 5.2 | -1.0 | 1.0 | 0.6 | 1.7 | -1.7 | 1.8 | 1.7 | -1.8 | 1.7 | -1.7 | 1.7 | -1.8 | -2.0 | 1.8 | -1.8 | 1.7 | 2.3 | -1.9 | 1.4 | 1.9 | 1.8 | -1.8 | -1.8 | -1.6 | 1.9 | 1.8 | -1.8 | -2.0 |
Pavlov. Cond. lever contacts | 2.9 | 4.1 | 5.8 | -1.7 | 1.7 | 1.1 | 2.2 | -2.2 | 2.0 | 2.0 | -1.9 | 2.1 | -2.1 | 2.1 | -2.0 | -1.7 | 2.1 | -2.1 | 2.2 | 2.1 | -2.2 | 1.0 | 1.8 | 2.2 | -2.3 | -2.2 | -2.4 | 2.1 | 2.2 | -2.0 | -2.1 |
Bone: final force | 2.8 | 4.6 | 5.9 | -1.6 | 1.5 | 0.9 | 2.1 | -2.1 | 2.3 | 2.1 | -2.1 | 2.1 | -2.1 | 2.1 | -2.3 | -2.2 | 2.2 | -2.2 | 2.1 | 2.3 | -2.4 | 1.7 | 2.1 | 2.2 | -2.2 | -2.3 | -2.4 | 2.3 | 2.2 | -2.2 | -2.4 |
Weight adjusted by age | 2.8 | 3.1 | 7.7 | -0.6 | 0.6 | -0.2 | 1.8 | -1.8 | 1.8 | 1.7 | -1.6 | 1.4 | -1.4 | 1.4 | -1.8 | -2.4 | 1.6 | -1.6 | 1.5 | 2.2 | -2.1 | 2.8 | 1.7 | 1.9 | -1.8 | -1.7 | -2.2 | 2.0 | 1.9 | -1.6 | -2.1 |
Pavlov. Cond. change in total contacts | 2.7 | 3.8 | 6.1 | -1.9 | 1.9 | 1.3 | 2.2 | -2.2 | 2.1 | 1.9 | -2.0 | 1.9 | -1.9 | 1.9 | -2.1 | -1.3 | 2.0 | -2.0 | 2.0 | 1.5 | -2.1 | 0.1 | 1.8 | 2.2 | -2.3 | -2.3 | -2.5 | 2.0 | 2.1 | -2.0 | -1.6 |
Progressive ratio test 1 breakpoint | 2.7 | 2.8 | 3.8 | -1.4 | 1.4 | 1.1 | 1.6 | -1.6 | 1.6 | 1.8 | -1.8 | 2.0 | -2.0 | 2.0 | -1.6 | -1.3 | 1.7 | -1.8 | 1.8 | 1.9 | -1.7 | 0.9 | 1.8 | 1.7 | -1.7 | -1.6 | -1.7 | 1.8 | 1.7 | -1.8 | -1.9 |
Locomotion distance, session 8 | 2.7 | 4.1 | 10.7 | -0.1 | -0.0 | -0.5 | 1.8 | -1.8 | 2.2 | 2.3 | -1.8 | 1.8 | -1.8 | 1.8 | -2.2 | -2.3 | 1.9 | -1.9 | 2.0 | 3.3 | -2.4 | 3.0 | 2.4 | 2.0 | -1.9 | -1.8 | -1.4 | 2.4 | 2.1 | -1.9 | -2.3 |
Bone: cortical area | 2.7 | 4.1 | 5.4 | -1.5 | 1.5 | 1.0 | 2.1 | -2.1 | 2.1 | 2.1 | -2.1 | 2.1 | -2.1 | 2.1 | -2.1 | -1.5 | 2.1 | -2.1 | 2.1 | 2.1 | -2.3 | 1.1 | 2.1 | 2.2 | -2.1 | -2.3 | -2.3 | 2.2 | 2.2 | -2.2 | -2.2 |
Bouts of movement, locomotor time 1 | 2.6 | 2.9 | 6.2 | 0.9 | -0.9 | -0.6 | -1.7 | 1.7 | -1.8 | -1.9 | 1.6 | -1.7 | 1.7 | -1.7 | 1.8 | 1.9 | -1.6 | 1.6 | -1.7 | -2.5 | 1.8 | -1.4 | -1.7 | -1.7 | 1.7 | 1.7 | 1.7 | -1.8 | -1.8 | 1.6 | 2.4 |
Total zone transitions, hab. session 2 | 2.5 | 3.2 | 4.2 | -1.5 | 1.4 | 1.1 | 2.0 | -2.0 | 1.8 | 1.8 | -1.9 | 1.9 | -1.9 | 1.9 | -1.8 | -1.4 | 1.9 | -1.9 | 2.1 | 2.0 | -1.9 | 0.8 | 2.0 | 1.9 | -1.9 | -1.8 | -1.7 | 2.0 | 1.9 | -2.0 | -1.8 |
Delta time to tail flick, test, before/after SA | 2.5 | 2.2 | 5.0 | 2.1 | -2.1 | -2.2 | -1.6 | 1.6 | -1.7 | -1.2 | 1.4 | -1.2 | 1.2 | -1.2 | 1.7 | 0.7 | -1.6 | 1.5 | -1.3 | -0.6 | 1.3 | 0.9 | -1.1 | -1.5 | 1.7 | 1.6 | 1.7 | -1.2 | -1.4 | 1.7 | 1.1 |
Bone: periosteal perimeter | 2.4 | 3.9 | 5.5 | -1.2 | 1.2 | 0.6 | 2.0 | -2.0 | 2.0 | 2.2 | -2.1 | 2.0 | -2.0 | 2.0 | -2.0 | -1.2 | 2.1 | -2.1 | 1.9 | 2.3 | -2.3 | 1.0 | 2.3 | 2.2 | -2.1 | -2.2 | -2.3 | 2.2 | 2.2 | -2.1 | -2.1 |
Ambulatory time before self-admin | 2.4 | 2.5 | 4.4 | -1.1 | 1.0 | 0.6 | 1.5 | -1.5 | 1.4 | 1.9 | -1.5 | 1.7 | -1.7 | 1.7 | -1.4 | -1.1 | 1.5 | -1.5 | 1.8 | 2.1 | -1.7 | 1.7 | 1.5 | 1.7 | -1.5 | -1.5 | -2.0 | 1.8 | 1.7 | -1.4 | -2.1 |
Conditioned locomotion | 2.3 | 2.7 | 4.8 | -0.6 | 0.6 | -0.2 | 1.7 | -1.7 | 1.8 | 1.9 | -1.7 | 1.6 | -1.6 | 1.6 | -1.8 | -0.8 | 1.6 | -1.6 | 1.6 | 1.5 | -2.2 | 1.6 | 1.9 | 2.0 | -1.8 | -2.0 | -2.1 | 2.0 | 1.9 | -1.7 | -1.0 |
Pavlov. Cond. index score | 2.3 | 3.0 | 4.5 | -1.6 | 1.6 | 1.1 | 1.9 | -1.9 | 1.8 | 1.8 | -1.7 | 1.8 | -1.8 | 1.8 | -1.8 | -1.2 | 1.8 | -1.8 | 1.9 | 1.8 | -1.9 | 0.4 | 1.6 | 1.9 | -2.1 | -2.0 | -2.1 | 1.8 | 1.9 | -1.7 | -1.7 |
Compulsive drug intake | 2.3 | 2.3 | 3.8 | 1.0 | -1.0 | -0.3 | -1.9 | 1.9 | -1.9 | -1.6 | 1.7 | -1.3 | 1.3 | -1.3 | 1.9 | 0.5 | -1.7 | 1.6 | -1.0 | -1.0 | 1.8 | -0.1 | -1.8 | -1.7 | 1.9 | 1.9 | 1.9 | -1.6 | -1.7 | 1.7 | 0.9 |
Breakpoint value in progressive ratio session | 2.3 | 2.6 | 3.7 | -1.8 | 1.8 | 1.4 | 1.8 | -1.8 | 1.8 | 1.5 | -1.7 | 1.6 | -1.6 | 1.6 | -1.8 | -0.1 | 1.8 | -1.7 | 1.3 | 0.9 | -1.6 | -0.5 | 1.6 | 1.8 | -1.7 | -1.8 | -1.9 | 1.6 | 1.7 | -1.9 | -1.1 |
Delta time to tail flick, vehicle, before/after SA | 2.3 | 2.2 | 3.0 | -1.6 | 1.6 | 1.4 | 1.6 | -1.6 | 1.6 | 1.6 | -1.6 | 1.5 | -1.5 | 1.5 | -1.6 | 0.0 | 1.6 | -1.6 | 1.3 | 1.2 | -1.4 | -0.3 | 1.6 | 1.7 | -1.7 | -1.6 | -1.7 | 1.5 | 1.6 | -1.6 | -1.3 |
Delay discounting total patch changes 24 sec | 2.2 | 2.7 | 6.5 | 2.3 | -2.3 | -2.5 | -1.9 | 1.9 | -1.4 | -1.4 | 1.7 | -1.6 | 1.6 | -1.6 | 1.4 | -1.2 | -1.5 | 1.6 | -1.7 | -0.9 | 1.3 | 2.1 | -1.5 | -1.4 | 1.7 | 1.8 | 1.3 | -1.2 | -1.4 | 1.7 | 1.2 |
Ambulatory time after self-admin | 2.2 | 2.4 | 3.7 | -1.5 | 1.5 | 1.4 | 1.6 | -1.6 | 1.6 | 1.9 | -1.7 | 1.5 | -1.5 | 1.5 | -1.6 | 0.1 | 1.7 | -1.7 | 1.0 | 1.5 | -1.4 | -0.5 | 1.9 | 1.8 | -1.6 | -1.6 | -1.7 | 1.6 | 1.8 | -1.7 | -1.5 |
Delay discounting time to switch 0 sec | 2.1 | 3.2 | 6.4 | 0.3 | -0.3 | 0.4 | -1.6 | 1.6 | -1.7 | -2.0 | 1.8 | -1.8 | 1.8 | -1.8 | 1.7 | 2.0 | -1.6 | 1.7 | -1.9 | -2.4 | 2.1 | -2.5 | -2.1 | -1.8 | 1.7 | 1.6 | 2.0 | -2.1 | -1.9 | 1.5 | 2.0 |
Progressive ratio test 1 active lever presses | 2.1 | 2.2 | 3.1 | -1.2 | 1.2 | 0.9 | 1.4 | -1.4 | 1.4 | 1.6 | -1.6 | 1.8 | -1.8 | 1.8 | -1.4 | -1.4 | 1.5 | -1.6 | 1.6 | 1.7 | -1.5 | 1.0 | 1.6 | 1.5 | -1.4 | -1.4 | -1.4 | 1.6 | 1.5 | -1.5 | -1.7 |
Degree of sensitization distance | 2.1 | 2.2 | 5.6 | 2.1 | -2.1 | -2.4 | -1.4 | 1.4 | -1.1 | -1.4 | 1.4 | -1.4 | 1.4 | -1.4 | 1.1 | -1.3 | -1.4 | 1.4 | -1.6 | -0.8 | 1.0 | 2.0 | -1.1 | -1.4 | 1.4 | 1.5 | 1.5 | -1.1 | -1.3 | 1.4 | 1.0 |
Bone: final moment | 2.1 | 3.5 | 4.8 | -1.4 | 1.4 | 0.8 | 1.9 | -1.9 | 2.0 | 1.9 | -1.9 | 1.8 | -1.8 | 1.8 | -2.0 | -1.9 | 1.9 | -1.9 | 1.8 | 2.1 | -2.1 | 1.4 | 1.9 | 2.0 | -1.9 | -2.0 | -2.1 | 2.0 | 1.9 | -1.9 | -2.2 |
Distance traveled after self-admin | 2.1 | 2.3 | 4.4 | -1.1 | 1.1 | 0.9 | 1.5 | -1.5 | 1.5 | 1.9 | -1.6 | 1.5 | -1.5 | 1.5 | -1.5 | -1.0 | 1.6 | -1.7 | 1.4 | 2.1 | -1.5 | 1.2 | 1.8 | 1.7 | -1.4 | -1.4 | -1.4 | 1.7 | 1.7 | -1.5 | -2.0 |
Time to tail flick, vehicle, before self-admin | 2.1 | 2.1 | 4.3 | 1.9 | -1.9 | -2.1 | -1.4 | 1.4 | -1.4 | -1.7 | 1.8 | -1.4 | 1.4 | -1.4 | 1.4 | -1.4 | -1.5 | 1.5 | -1.3 | -0.4 | 1.1 | 1.2 | -1.7 | -1.4 | 1.5 | 1.4 | 1.3 | -1.2 | -1.4 | 1.5 | 0.7 |
Pavlov. Cond. lever-magazine prob. diff. | 2.0 | 2.5 | 4.0 | -1.4 | 1.4 | 1.0 | 1.8 | -1.8 | 1.7 | 1.7 | -1.5 | 1.6 | -1.6 | 1.6 | -1.7 | -0.9 | 1.6 | -1.6 | 1.7 | 1.6 | -1.7 | 0.3 | 1.4 | 1.8 | -1.9 | -1.9 | -2.0 | 1.7 | 1.8 | -1.5 | -1.5 |
Post-drug Anxiety | 2.0 | 2.2 | 3.5 | 1.6 | -1.6 | -1.7 | -1.3 | 1.3 | -1.3 | -1.5 | 1.5 | -1.9 | 1.9 | -1.9 | 1.3 | 0.6 | -1.5 | 1.5 | -1.8 | -1.6 | 1.3 | -0.5 | -1.3 | -1.4 | 1.3 | 1.3 | 1.3 | -1.4 | -1.4 | 1.5 | 1.8 |
Time to tail flick, test, after self-admin | 2.0 | 2.0 | 3.4 | 1.8 | -1.8 | -1.7 | -1.4 | 1.4 | -1.4 | -1.3 | 1.6 | -1.4 | 1.4 | -1.4 | 1.4 | 1.0 | -1.6 | 1.6 | -1.3 | -1.0 | 1.2 | 0.3 | -1.4 | -1.5 | 1.4 | 1.4 | 1.5 | -1.3 | -1.5 | 1.6 | 1.3 |
Total resting periods, locomotor time 1 | 2.0 | 2.2 | 5.5 | 0.6 | -0.6 | -0.2 | -1.4 | 1.4 | -1.4 | -1.7 | 1.3 | -1.5 | 1.5 | -1.5 | 1.4 | 1.8 | -1.3 | 1.3 | -1.5 | -2.3 | 1.5 | -1.7 | -1.5 | -1.4 | 1.4 | 1.4 | 1.5 | -1.6 | -1.5 | 1.3 | 2.2 |
Cu content in liver | 2.0 | 2.5 | 3.2 | -1.4 | 1.3 | 1.2 | 1.7 | -1.7 | 1.8 | 1.8 | -1.5 | 1.6 | -1.6 | 1.6 | -1.8 | 0.5 | 1.6 | -1.6 | 1.7 | 1.6 | -1.6 | -0.3 | 1.6 | 1.7 | -1.7 | -1.7 | -1.6 | 1.7 | 1.7 | -1.7 | -1.3 |
Mn content in liver | 1.9 | 2.1 | 2.9 | -1.3 | 1.3 | 1.1 | 1.5 | -1.5 | 1.3 | 1.6 | -1.6 | 1.7 | -1.7 | 1.7 | -1.3 | -0.3 | 1.6 | -1.6 | 1.7 | 1.3 | -1.6 | 0.1 | 1.6 | 1.6 | -1.6 | -1.6 | -1.5 | 1.6 | 1.6 | -1.5 | -1.2 |
Locomotion distance, session 2 | 1.8 | 2.6 | 4.3 | -0.4 | 0.3 | -0.1 | 1.7 | -1.7 | 1.8 | 1.8 | -1.7 | 1.6 | -1.6 | 1.6 | -1.8 | -1.1 | 1.7 | -1.7 | 1.8 | 2.0 | -2.0 | 1.8 | 2.1 | 1.7 | -1.7 | -1.6 | -1.1 | 2.0 | 1.7 | -1.8 | -1.2 |
Delay disc. indifference point, 24s delay | 1.8 | 1.8 | 2.9 | 1.1 | -1.1 | -0.6 | -1.4 | 1.4 | -1.4 | -1.7 | 1.5 | -1.4 | 1.4 | -1.4 | 1.4 | 1.3 | -1.5 | 1.5 | -1.0 | -1.3 | 1.2 | 0.1 | -1.7 | -1.5 | 1.4 | 1.2 | 1.6 | -1.4 | -1.5 | 1.5 | 1.2 |
Run reversals in cocaine runway, males | 1.8 | 1.8 | 3.5 | -0.8 | 0.7 | 0.6 | 1.1 | -1.1 | 1.1 | 1.6 | -1.6 | 1.6 | -1.6 | 1.6 | -1.1 | -0.3 | 1.6 | -1.5 | 1.9 | 1.7 | -1.4 | 1.1 | 1.7 | 1.4 | -1.0 | -1.1 | -0.9 | 1.6 | 1.4 | -1.5 | -1.3 |
Delay discounting water rate 6 sec | 1.7 | 2.5 | 3.7 | -1.0 | 1.0 | 0.6 | 1.5 | -1.5 | 1.5 | 1.6 | -1.6 | 1.9 | -1.9 | 1.9 | -1.5 | -1.8 | 1.6 | -1.6 | 1.6 | 1.8 | -1.7 | 1.3 | 1.6 | 1.7 | -1.6 | -1.5 | -1.8 | 1.7 | 1.7 | -1.4 | -1.7 |
Reaction time num false alarms AUC | 1.7 | 2.4 | 3.6 | -0.9 | 0.9 | 0.3 | 1.6 | -1.6 | 1.4 | 1.7 | -1.6 | 1.7 | -1.7 | 1.7 | -1.4 | -0.7 | 1.5 | -1.6 | 1.8 | 1.7 | -1.9 | 1.7 | 1.7 | 1.7 | -1.4 | -1.6 | -1.6 | 1.8 | 1.7 | -1.5 | -1.5 |
Stereotopy head waving bouts, day 3 | 1.7 | 2.0 | 5.4 | 2.0 | -2.1 | -2.3 | -1.3 | 1.3 | -1.4 | -1.1 | 1.5 | -1.4 | 1.4 | -1.4 | 1.4 | 1.1 | -1.4 | 1.4 | -1.5 | -1.4 | 0.9 | 0.9 | -1.2 | -1.1 | 1.3 | 1.3 | 1.0 | -1.0 | -1.1 | 1.4 | 1.9 |
Locomotion distance, session 7 | 1.7 | 2.1 | 9.0 | -0.2 | 0.1 | -0.3 | 1.3 | -1.3 | 1.7 | 1.2 | -1.3 | 1.2 | -1.2 | 1.2 | -1.7 | -3.0 | 1.3 | -1.3 | 1.1 | 2.3 | -1.5 | 2.3 | 1.6 | 1.2 | -1.2 | -1.2 | -0.8 | 1.5 | 1.3 | -1.3 | -2.0 |
Degree of sensitization stereotypy | 1.7 | 1.9 | 3.8 | -2.0 | 2.0 | 1.9 | 1.4 | -1.4 | 1.2 | 1.2 | -1.2 | 1.3 | -1.3 | 1.3 | -1.2 | 0.5 | 1.4 | -1.3 | 1.3 | 0.8 | -1.1 | -1.4 | 1.0 | 1.4 | -1.4 | -1.6 | -1.7 | 1.1 | 1.4 | -1.3 | -1.2 |
Bone: periosteal estimation | 1.7 | 3.5 | 5.0 | -1.3 | 1.3 | 0.8 | 2.0 | -2.0 | 1.9 | 1.9 | -1.9 | 1.8 | -1.8 | 1.8 | -1.9 | -1.7 | 1.9 | -2.0 | 1.7 | 2.2 | -2.1 | 0.9 | 2.0 | 2.0 | -2.0 | -2.1 | -2.2 | 2.0 | 2.0 | -1.9 | -2.2 |
Mg content in liver | 1.7 | 1.8 | 2.5 | -0.9 | 0.9 | 0.7 | 1.5 | -1.5 | 1.5 | 1.5 | -1.5 | 1.6 | -1.6 | 1.6 | -1.5 | 0.0 | 1.3 | -1.4 | 1.5 | 1.2 | -1.5 | 0.2 | 1.5 | 1.4 | -1.3 | -1.4 | -1.3 | 1.5 | 1.4 | -1.4 | -0.9 |
Reaction time num false alarms | 1.6 | 2.3 | 4.4 | -0.6 | 0.5 | -0.1 | 1.5 | -1.5 | 1.3 | 1.7 | -1.5 | 1.5 | -1.5 | 1.5 | -1.3 | -1.0 | 1.5 | -1.5 | 1.8 | 1.9 | -1.9 | 2.1 | 1.7 | 1.6 | -1.4 | -1.5 | -1.5 | 1.8 | 1.6 | -1.5 | -1.5 |
Pavlov. Cond. latency score | 1.6 | 2.1 | 3.4 | -1.2 | 1.2 | 0.7 | 1.6 | -1.6 | 1.5 | 1.5 | -1.3 | 1.5 | -1.5 | 1.5 | -1.5 | -1.1 | 1.5 | -1.5 | 1.5 | 1.4 | -1.6 | 0.6 | 1.3 | 1.6 | -1.8 | -1.7 | -1.8 | 1.5 | 1.6 | -1.4 | -1.3 |
Bone: endosteal perimeter | 1.6 | 3.3 | 5.0 | -1.1 | 1.1 | 0.5 | 1.8 | -1.8 | 1.7 | 2.0 | -2.0 | 1.8 | -1.8 | 1.8 | -1.7 | -1.7 | 2.0 | -2.0 | 1.6 | 2.2 | -2.0 | 1.2 | 2.1 | 2.0 | -1.9 | -1.9 | -2.2 | 2.0 | 2.0 | -2.0 | -2.0 |
Condit. Reinf. lever presses | 1.5 | 2.0 | 2.6 | -1.3 | 1.3 | 0.9 | 1.5 | -1.5 | 1.6 | 1.4 | -1.4 | 1.5 | -1.5 | 1.5 | -1.6 | -1.1 | 1.5 | -1.5 | 1.6 | 1.4 | -1.5 | 0.4 | 1.3 | 1.5 | -1.6 | -1.6 | -1.6 | 1.5 | 1.5 | -1.5 | -1.3 |
Bone: trabecular number | 1.4 | 2.2 | 5.8 | -0.6 | 0.6 | 0.2 | 1.3 | -1.3 | 1.6 | 1.5 | -1.5 | 1.6 | -1.6 | 1.6 | -1.6 | -2.2 | 1.3 | -1.5 | 1.6 | 2.4 | -1.5 | 2.0 | 1.6 | 1.3 | -1.2 | -1.2 | -1.0 | 1.6 | 1.4 | -1.3 | -2.0 |
Locomotion in novel chamber post-restriction | 1.4 | 1.7 | 2.6 | -1.4 | 1.3 | 1.4 | 1.3 | -1.3 | 1.2 | 1.5 | -1.6 | 1.3 | -1.3 | 1.3 | -1.2 | 0.6 | 1.4 | -1.4 | 1.2 | 1.3 | -1.2 | -0.5 | 1.6 | 1.4 | -1.3 | -1.3 | -1.3 | 1.3 | 1.4 | -1.4 | -1.2 |
Latency to leave start box in cocaine runway, F | 1.4 | 1.6 | 4.2 | 0.5 | -0.5 | -0.1 | -1.3 | 1.3 | -1.3 | -1.0 | 0.8 | -1.0 | 1.0 | -1.0 | 1.3 | 2.1 | -1.0 | 1.0 | -1.1 | -1.8 | 1.6 | -2.0 | -0.7 | -1.1 | 1.4 | 1.6 | 1.2 | -1.2 | -1.2 | 0.8 | 1.8 |
Se content in liver | 1.3 | 1.5 | 2.7 | -0.5 | 0.4 | -0.0 | 1.1 | -1.1 | 1.1 | 1.3 | -1.3 | 1.3 | -1.3 | 1.3 | -1.1 | -1.6 | 1.3 | -1.3 | 1.3 | 1.6 | -1.5 | 1.6 | 1.5 | 1.2 | -1.1 | -1.2 | -0.9 | 1.4 | 1.2 | -1.4 | -1.3 |
Conditioned reinforcement - inactives | 1.2 | 1.4 | 10.4 | 0.6 | -0.7 | -1.3 | 0.8 | -0.8 | 0.8 | 1.0 | -0.6 | 0.7 | -0.7 | 0.7 | -0.8 | -2.3 | 0.7 | -0.8 | 1.1 | 1.9 | -1.3 | 3.2 | 0.9 | 0.9 | -0.8 | -0.8 | -0.7 | 1.3 | 0.9 | -0.7 | -1.2 |
Locomotion velocity, session 3 | 1.2 | 1.4 | 2.6 | -1.5 | 1.5 | 1.6 | 1.2 | -1.2 | 1.1 | 1.2 | -1.1 | 1.1 | -1.1 | 1.1 | -1.1 | 0.6 | 1.2 | -1.2 | 1.2 | 1.0 | -0.9 | -1.3 | 1.0 | 1.2 | -1.2 | -1.2 | -1.2 | 1.0 | 1.2 | -1.2 | -1.0 |
Stereotopy head waving duration, day 3 | 1.2 | 1.4 | 3.2 | 1.4 | -1.4 | -1.4 | -1.1 | 1.1 | -1.2 | -1.0 | 1.2 | -1.2 | 1.2 | -1.2 | 1.2 | 1.6 | -1.2 | 1.2 | -1.3 | -1.5 | 1.0 | -0.2 | -1.1 | -1.0 | 1.1 | 1.2 | 0.8 | -1.0 | -1.0 | 1.2 | 1.8 |
Time in novel zone, hab. session 2 | 1.2 | 1.2 | 2.1 | -1.1 | 1.1 | 0.9 | 1.1 | -1.1 | 1.5 | 1.0 | -1.0 | 1.0 | -1.0 | 1.0 | -1.5 | -0.8 | 1.2 | -1.1 | 1.0 | 1.0 | -1.1 | -0.0 | 0.9 | 1.2 | -1.3 | -1.2 | -1.3 | 1.0 | 1.2 | -1.2 | -1.1 |
Bone: cortical thickness | 1.2 | 2.0 | 2.7 | -1.3 | 1.2 | 1.0 | 1.6 | -1.6 | 1.6 | 1.4 | -1.5 | 1.5 | -1.5 | 1.5 | -1.6 | -0.5 | 1.5 | -1.5 | 1.6 | 1.0 | -1.7 | 0.4 | 1.4 | 1.5 | -1.5 | -1.7 | -1.5 | 1.5 | 1.5 | -1.5 | -1.3 |
Bone: post-yield work | 1.2 | 1.6 | 2.6 | 1.2 | -1.2 | -1.1 | -1.4 | 1.4 | -1.6 | -1.2 | 1.3 | -1.3 | 1.3 | -1.3 | 1.6 | 0.6 | -1.4 | 1.4 | -1.4 | -1.3 | 1.2 | -0.2 | -1.4 | -1.3 | 1.3 | 1.3 | 0.9 | -1.3 | -1.3 | 1.5 | 1.3 |
Bone: stiffness | 1.2 | 1.8 | 2.8 | -0.7 | 0.6 | 0.0 | 1.3 | -1.3 | 1.5 | 1.4 | -1.4 | 1.4 | -1.4 | 1.4 | -1.5 | -1.4 | 1.4 | -1.4 | 1.3 | 1.1 | -1.7 | 1.5 | 1.5 | 1.5 | -1.4 | -1.5 | -1.7 | 1.5 | 1.4 | -1.4 | -1.2 |
Bone: trabecular tissue density | 1.2 | 1.7 | 2.8 | -0.6 | 0.5 | -0.0 | 1.4 | -1.4 | 1.5 | 1.4 | -1.4 | 1.4 | -1.4 | 1.4 | -1.5 | -0.9 | 1.3 | -1.3 | 1.4 | 1.2 | -1.7 | 1.6 | 1.5 | 1.4 | -1.4 | -1.5 | -1.4 | 1.5 | 1.4 | -1.3 | -1.0 |
Delta time in open arm before/after self-admin | 1.2 | 1.2 | 3.6 | -0.1 | 0.1 | 0.1 | 0.9 | -0.9 | 0.9 | 1.5 | -0.9 | 1.5 | -1.5 | 1.5 | -0.9 | 0.8 | 1.0 | -1.0 | 1.3 | 1.9 | -1.1 | 0.7 | 1.2 | 1.0 | -0.8 | -0.9 | -0.7 | 1.3 | 1.2 | -1.0 | -1.1 |
BMI with tail | 1.1 | 3.6 | 5.6 | -2.0 | 2.0 | 2.0 | 1.8 | -1.8 | 2.0 | 1.9 | -1.8 | 2.1 | -2.1 | 2.1 | -2.0 | -1.1 | 1.9 | -1.9 | 2.0 | 2.2 | -1.7 | 0.2 | 1.7 | 1.9 | -1.9 | -1.9 | -1.8 | 1.9 | 1.9 | -2.0 | -2.4 |
Tibialis anterior weight | 1.1 | 3.9 | 6.1 | -1.7 | 1.7 | 1.4 | 2.2 | -2.2 | 2.1 | 1.9 | -2.0 | 2.0 | -2.0 | 2.0 | -2.1 | -1.8 | 2.1 | -2.1 | 1.9 | 2.5 | -2.0 | 0.4 | 2.1 | 2.0 | -2.1 | -2.1 | -1.7 | 2.0 | 2.0 | -2.0 | -2.3 |
Intermittent access intake day 1-15 change | 1.1 | 1.1 | 5.0 | -0.4 | 0.3 | 0.4 | 0.4 | -0.4 | 0.5 | 1.0 | -0.8 | 1.2 | -1.2 | 1.2 | -0.5 | -1.5 | 0.9 | -0.9 | 1.3 | 2.2 | -0.8 | 2.0 | 0.8 | 0.7 | -0.5 | -0.5 | -0.5 | 1.1 | 0.8 | -0.7 | -2.0 |
Baseline Anxiety | 1.1 | 1.2 | 1.8 | -1.2 | 1.2 | 1.3 | 1.2 | -1.2 | 1.2 | 0.9 | -1.0 | 1.2 | -1.2 | 1.2 | -1.2 | -0.4 | 1.1 | -1.1 | 1.3 | 1.3 | -1.1 | 0.4 | 0.9 | 1.0 | -1.1 | -1.2 | -0.8 | 1.0 | 1.0 | -1.0 | -1.4 |
Time in familiar zone, hab. session 2 | 1.1 | 1.1 | 1.9 | 1.1 | -1.1 | -0.8 | -1.1 | 1.1 | -1.3 | -1.0 | 1.0 | -1.0 | 1.0 | -1.0 | 1.3 | 0.8 | -1.1 | 1.1 | -1.0 | -1.0 | 1.1 | -0.1 | -0.9 | -1.2 | 1.2 | 1.2 | 1.4 | -1.0 | -1.2 | 1.2 | 1.1 |
Total locomotion distance, hab. session 2 | 1.1 | 1.5 | 7.3 | 0.3 | -0.4 | -1.1 | 1.1 | -1.1 | 1.0 | 1.1 | -1.1 | 1.1 | -1.1 | 1.1 | -1.0 | -1.8 | 1.1 | -1.1 | 1.2 | 1.4 | -1.6 | 2.7 | 1.4 | 1.2 | -1.0 | -1.0 | -0.8 | 1.5 | 1.2 | -1.1 | -0.9 |
Bone: minimum diameter | 1.1 | 2.0 | 2.9 | -1.0 | 1.0 | 0.7 | 1.5 | -1.5 | 1.4 | 1.6 | -1.5 | 1.5 | -1.5 | 1.5 | -1.4 | -0.7 | 1.5 | -1.5 | 1.4 | 1.5 | -1.6 | 0.4 | 1.6 | 1.6 | -1.5 | -1.6 | -1.7 | 1.5 | 1.5 | -1.5 | -1.4 |
Delta ambulatory time before/after self-admin | 1.1 | 1.2 | 8.2 | -0.1 | 0.1 | 0.7 | -0.6 | 0.6 | -0.6 | -1.0 | 0.7 | -1.2 | 1.2 | -1.2 | 0.6 | 1.2 | -0.7 | 0.7 | -1.6 | -1.7 | 1.2 | -2.9 | -0.8 | -0.8 | 0.6 | 0.6 | 0.8 | -1.2 | -0.9 | 0.7 | 1.4 |
Time to tail flick, test, before self-admin | 1.1 | 1.1 | 2.2 | -1.3 | 1.3 | 1.4 | 1.5 | -1.5 | 1.5 | 0.7 | -0.7 | 0.4 | -0.4 | 0.4 | -1.5 | -0.7 | 1.0 | -0.9 | 0.8 | 0.5 | -1.1 | -0.6 | 0.6 | 1.0 | -1.4 | -1.5 | -1.3 | 0.9 | 1.0 | -1.1 | -0.8 |
Food consumed during 24 hour testing period | 1.0 | 1.2 | 1.9 | 1.3 | -1.3 | -1.2 | -1.2 | 1.2 | -1.4 | -0.9 | 1.1 | -1.1 | 1.1 | -1.1 | 1.4 | -0.1 | -1.2 | 1.1 | -1.1 | -0.8 | 1.1 | 0.6 | -1.0 | -1.1 | 1.1 | 1.2 | 1.1 | -1.0 | -1.1 | 1.2 | 0.8 |
Delay discounting total patch changes 18 sec | 1.0 | 1.3 | 3.0 | 1.6 | -1.6 | -1.7 | -1.1 | 1.1 | -0.8 | -0.9 | 1.3 | -1.2 | 1.2 | -1.2 | 0.8 | 0.1 | -1.1 | 1.2 | -1.4 | -0.9 | 0.8 | 1.0 | -1.1 | -1.0 | 1.1 | 1.1 | 0.9 | -0.9 | -1.0 | 1.3 | 1.1 |
Reaction time false alarm rate | 1.0 | 1.4 | 2.5 | -0.8 | 0.8 | 0.4 | 1.2 | -1.2 | 1.0 | 1.2 | -1.3 | 1.3 | -1.3 | 1.3 | -1.0 | -0.8 | 1.3 | -1.3 | 1.6 | 1.3 | -1.4 | 1.4 | 1.3 | 1.3 | -1.1 | -1.2 | -1.0 | 1.4 | 1.3 | -1.3 | -1.2 |
Social response proportion | 1.0 | 1.1 | 2.2 | -0.3 | 0.3 | -0.1 | 1.5 | -1.5 | 1.3 | 1.4 | -1.2 | 0.8 | -0.8 | 0.8 | -1.3 | 0.4 | 1.0 | -1.0 | 0.7 | 0.7 | -1.4 | 0.1 | 1.3 | 1.3 | -1.3 | -1.4 | -1.3 | 1.2 | 1.3 | -1.1 | -0.2 |
Locomotion velocity, session 7 | 1.0 | 1.1 | 2.3 | -0.6 | 0.6 | 0.4 | 1.1 | -1.1 | 1.1 | 1.1 | -1.0 | 1.0 | -1.0 | 1.0 | -1.1 | -1.3 | 1.1 | -1.0 | 0.8 | 1.5 | -1.0 | 0.4 | 1.1 | 1.0 | -1.0 | -1.1 | -1.1 | 1.0 | 1.1 | -1.0 | -1.5 |
Condit. Reinf. active minus inactive responses | 1.0 | 1.1 | 1.8 | -1.1 | 1.1 | 0.9 | 1.2 | -1.2 | 1.0 | 0.8 | -1.1 | 1.0 | -1.0 | 1.0 | -1.0 | -0.9 | 1.2 | -1.1 | 1.1 | 0.7 | -1.2 | -0.1 | 0.9 | 1.1 | -1.2 | -1.3 | -0.9 | 1.0 | 1.0 | -1.2 | -0.8 |
Condit. Reinf. active-inactive response ratio | 1.0 | 1.1 | 1.7 | -0.7 | 0.7 | 0.3 | 1.2 | -1.2 | 1.0 | 1.0 | -1.1 | 1.1 | -1.1 | 1.1 | -1.0 | -1.3 | 1.1 | -1.1 | 1.1 | 1.0 | -1.2 | 0.7 | 1.1 | 1.1 | -1.2 | -1.2 | -0.9 | 1.2 | 1.0 | -1.2 | -0.9 |
Bone: apparent density | 1.0 | 1.7 | 5.4 | -0.2 | 0.2 | -0.0 | 1.2 | -1.2 | 1.4 | 1.5 | -1.3 | 1.4 | -1.4 | 1.4 | -1.4 | -1.5 | 1.1 | -1.3 | 1.5 | 2.3 | -1.3 | 1.8 | 1.6 | 1.1 | -1.0 | -0.9 | -0.7 | 1.5 | 1.2 | -1.1 | -1.7 |
Epididymis fat weight | 0.9 | 2.0 | 3.6 | -1.4 | 1.3 | 1.1 | 1.5 | -1.5 | 1.4 | 1.6 | -1.5 | 1.3 | -1.3 | 1.3 | -1.4 | -0.3 | 1.5 | -1.5 | 1.2 | 1.4 | -1.4 | -0.0 | 1.6 | 1.6 | -1.6 | -1.6 | -1.9 | 1.5 | 1.6 | -1.5 | -1.3 |
Length without tail | 0.9 | 1.9 | 3.3 | -0.7 | 0.7 | -0.1 | 1.6 | -1.6 | 1.6 | 1.4 | -1.4 | 1.3 | -1.3 | 1.3 | -1.6 | -1.1 | 1.4 | -1.3 | 1.5 | 1.2 | -1.8 | 1.3 | 1.5 | 1.6 | -1.6 | -1.7 | -1.8 | 1.6 | 1.6 | -1.5 | -1.0 |
Time in familiar zone, hab. session 1 | 0.9 | 0.8 | 1.8 | 0.6 | -0.6 | -0.2 | -0.9 | 0.9 | -1.3 | -0.8 | 0.8 | -0.8 | 0.8 | -0.8 | 1.3 | 1.2 | -0.9 | 0.9 | -0.9 | -0.7 | 1.1 | -1.1 | -0.8 | -1.0 | 0.9 | 1.0 | 1.1 | -0.9 | -0.9 | 0.9 | 0.7 |
Total locomotion distance, NPP test | 0.9 | 1.2 | 9.4 | 0.7 | -0.8 | -1.4 | 0.7 | -0.7 | 0.6 | 0.7 | -0.7 | 0.6 | -0.6 | 0.6 | -0.6 | -2.6 | 0.7 | -0.7 | 0.8 | 1.4 | -1.2 | 3.1 | 1.0 | 0.7 | -0.6 | -0.6 | -0.3 | 1.1 | 0.8 | -0.6 | -0.9 |
Time in closed arm after self-admin | 0.9 | 0.9 | 4.8 | -0.0 | 0.0 | 0.3 | -0.7 | 0.7 | -0.7 | -0.8 | 0.6 | -1.0 | 1.0 | -1.0 | 0.7 | 1.6 | -0.7 | 0.7 | -1.3 | -1.5 | 1.1 | -2.2 | -0.7 | -0.8 | 0.7 | 0.7 | 0.7 | -1.1 | -0.9 | 0.7 | 1.1 |
Co content in liver | 0.9 | 1.1 | 1.8 | -0.7 | 0.7 | 0.4 | 1.1 | -1.1 | 1.2 | 1.1 | -1.1 | 1.2 | -1.2 | 1.2 | -1.2 | 0.2 | 1.0 | -1.0 | 1.4 | 1.2 | -1.2 | 0.6 | 1.1 | 1.1 | -1.1 | -1.1 | -0.9 | 1.2 | 1.1 | -1.1 | -1.1 |
Light reinforcement 1 | 0.8 | 1.5 | 2.3 | -1.2 | 1.2 | 0.8 | 1.5 | -1.5 | 1.3 | 1.1 | -1.2 | 1.2 | -1.2 | 1.2 | -1.3 | -0.4 | 1.4 | -1.3 | 1.2 | 0.9 | -1.4 | 0.2 | 1.1 | 1.4 | -1.4 | -1.5 | -1.4 | 1.2 | 1.3 | -1.3 | -1.2 |
Reaction time mean minus median | 0.8 | 1.0 | 2.1 | 1.0 | -1.0 | -0.9 | -0.9 | 0.9 | -0.8 | -1.1 | 0.9 | -1.2 | 1.2 | -1.2 | 0.8 | 0.1 | -1.0 | 1.0 | -1.5 | -1.2 | 1.0 | -0.1 | -0.9 | -1.0 | 0.9 | 1.0 | 1.0 | -1.0 | -1.0 | 0.9 | 1.3 |
Reaction time omissions | 0.8 | 1.1 | 2.4 | -0.5 | 0.4 | 0.2 | 1.1 | -1.1 | 1.1 | 1.2 | -1.4 | 0.9 | -0.9 | 0.9 | -1.1 | 0.1 | 1.1 | -1.2 | 1.0 | 0.9 | -1.3 | 0.9 | 1.5 | 1.1 | -1.1 | -1.1 | -0.8 | 1.3 | 1.1 | -1.2 | -0.5 |
Condit. Reinf. inactive responses | 0.8 | 1.0 | 1.7 | -0.5 | 0.5 | 0.2 | 1.1 | -1.1 | 1.2 | 1.3 | -1.1 | 1.1 | -1.1 | 1.1 | -1.2 | 0.9 | 1.0 | -1.1 | 1.1 | 1.0 | -1.1 | 0.2 | 1.3 | 1.2 | -1.0 | -1.0 | -1.0 | 1.2 | 1.1 | -1.1 | -0.6 |
Intermittent access intake escalation | 0.8 | 0.8 | 3.9 | -0.2 | 0.2 | 0.3 | 0.3 | -0.3 | 0.2 | 0.7 | -0.5 | 1.0 | -1.0 | 1.0 | -0.2 | -1.5 | 0.6 | -0.7 | 1.1 | 2.0 | -0.6 | 1.9 | 0.5 | 0.5 | -0.3 | -0.3 | -0.3 | 0.8 | 0.6 | -0.5 | -1.8 |
Short access day 1 locomotion | 0.8 | 0.8 | 1.5 | 1.2 | -1.2 | -0.9 | -1.2 | 1.2 | -1.2 | -0.5 | 1.0 | -0.6 | 0.6 | -0.6 | 1.2 | 0.8 | -1.0 | 0.9 | -0.5 | 0.0 | 0.9 | 0.3 | -0.6 | -0.9 | 1.2 | 1.2 | 1.1 | -0.7 | -0.8 | 1.0 | 0.4 |
Bone surface | 0.8 | 1.4 | 2.9 | -0.3 | 0.2 | -0.1 | 1.2 | -1.2 | 1.2 | 1.4 | -1.2 | 1.1 | -1.1 | 1.1 | -1.2 | -1.2 | 1.1 | -1.2 | 1.1 | 1.7 | -1.3 | 1.6 | 1.4 | 1.2 | -1.1 | -1.0 | -1.0 | 1.4 | 1.2 | -1.1 | -1.3 |
Bone volume | 0.8 | 1.4 | 3.1 | -0.2 | 0.2 | -0.2 | 1.1 | -1.1 | 1.3 | 1.4 | -1.2 | 1.2 | -1.2 | 1.2 | -1.3 | -1.4 | 1.0 | -1.1 | 1.2 | 1.7 | -1.3 | 1.8 | 1.4 | 1.1 | -1.0 | -1.0 | -1.0 | 1.3 | 1.1 | -1.0 | -1.5 |
Sum of active levers in priming session hrs 5-6 | 0.8 | 0.7 | 1.3 | -0.4 | 0.4 | -0.3 | 1.0 | -1.0 | 1.0 | 1.0 | -1.1 | 0.8 | -0.8 | 0.8 | -1.0 | -0.4 | 1.0 | -1.0 | 0.6 | 0.4 | -1.0 | -0.1 | 1.1 | 1.1 | -0.9 | -1.0 | -1.0 | 1.0 | 1.0 | -1.1 | -0.3 |
Intermitt. access day 15 inactive lever presses | 0.7 | 0.7 | 6.6 | 1.4 | -1.4 | -2.0 | -0.3 | 0.3 | -0.3 | -0.0 | 0.5 | -0.2 | 0.2 | -0.2 | 0.3 | -2.0 | -0.4 | 0.4 | -0.1 | 0.7 | -0.3 | 2.6 | -0.2 | -0.2 | 0.3 | 0.2 | 0.2 | 0.1 | -0.2 | 0.5 | -0.2 |
Progressive ratio test 2 inactive lever presses | 0.7 | 0.8 | 5.5 | 0.6 | -0.6 | -1.0 | 0.3 | -0.3 | 0.4 | 0.8 | -0.4 | 0.8 | -0.8 | 0.8 | -0.4 | -1.9 | 0.5 | -0.5 | 0.8 | 1.7 | -0.8 | 2.3 | 0.7 | 0.5 | -0.3 | -0.3 | -0.4 | 0.9 | 0.6 | -0.4 | -1.0 |
Locomotion velocity, hab. session 2 | 0.7 | 1.0 | 7.7 | 0.7 | -0.8 | -1.5 | 0.8 | -0.8 | 0.7 | 0.8 | -0.7 | 0.7 | -0.7 | 0.7 | -0.7 | -1.5 | 0.7 | -0.7 | 0.8 | 1.0 | -1.3 | 2.8 | 1.1 | 0.8 | -0.7 | -0.7 | -0.4 | 1.2 | 0.8 | -0.7 | -0.5 |
Bone: cortical apparent density | 0.7 | 0.9 | 1.9 | -1.4 | 1.4 | 1.2 | 1.2 | -1.2 | 1.3 | 0.5 | -0.8 | 0.8 | -0.8 | 0.8 | -1.3 | 0.2 | 1.0 | -0.9 | 0.9 | -0.1 | -1.0 | -0.8 | 0.5 | 1.0 | -1.2 | -1.2 | -1.0 | 0.7 | 0.9 | -1.1 | -0.5 |
Delay disc. indifference point, 16s delay | 0.7 | 0.7 | 1.4 | 0.5 | -0.5 | -0.4 | -1.0 | 1.0 | -1.0 | -1.1 | 0.9 | -0.9 | 0.9 | -0.9 | 1.0 | -0.1 | -0.8 | 0.8 | -0.6 | -0.9 | 0.8 | -0.2 | -1.2 | -0.9 | 0.9 | 0.8 | 0.8 | -0.9 | -0.9 | 0.9 | 0.7 |
Bouts of movement, locomotor time 2 | 0.7 | 0.8 | 1.5 | -0.1 | 0.2 | 0.6 | -0.8 | 0.8 | -1.0 | -1.2 | 1.0 | -1.1 | 1.1 | -1.1 | 1.0 | 0.1 | -0.8 | 0.8 | -0.7 | -0.9 | 0.9 | -1.2 | -1.2 | -0.9 | 0.8 | 0.6 | 0.8 | -1.0 | -0.9 | 0.9 | 0.5 |
Latency to leave start box in cocaine runway | 0.7 | 0.8 | 2.4 | 0.5 | -0.4 | -0.4 | -0.8 | 0.8 | -0.9 | -0.7 | 0.6 | -0.8 | 0.8 | -0.8 | 0.9 | 1.3 | -0.7 | 0.8 | -0.9 | -1.6 | 1.0 | -1.4 | -0.5 | -0.8 | 0.9 | 1.0 | 0.8 | -0.9 | -0.9 | 0.5 | 1.5 |
Left kidney weight | 0.6 | 1.7 | 5.8 | -0.1 | 0.0 | -0.7 | 1.1 | -1.1 | 1.3 | 1.3 | -1.1 | 1.1 | -1.1 | 1.1 | -1.3 | -1.8 | 1.1 | -1.1 | 0.9 | 1.5 | -1.6 | 2.4 | 1.4 | 1.4 | -1.3 | -1.1 | -1.5 | 1.5 | 1.4 | -1.3 | -1.2 |
Right kidney weight | 0.6 | 1.7 | 4.0 | -0.1 | 0.1 | -0.6 | 1.2 | -1.2 | 1.4 | 1.5 | -1.4 | 1.2 | -1.2 | 1.2 | -1.4 | -1.4 | 1.2 | -1.3 | 0.7 | 1.4 | -1.6 | 2.0 | 1.7 | 1.4 | -1.3 | -1.2 | -1.5 | 1.5 | 1.4 | -1.5 | -1.0 |
Light reinforcement 2 | 0.6 | 0.8 | 1.4 | -0.8 | 0.8 | 0.5 | 1.2 | -1.2 | 1.0 | 0.8 | -0.9 | 0.7 | -0.7 | 0.7 | -1.0 | -0.9 | 0.9 | -0.9 | 0.6 | 0.6 | -1.0 | 0.1 | 0.9 | 1.0 | -1.1 | -1.1 | -1.1 | 0.8 | 0.9 | -0.9 | -0.8 |
Pavlov. Cond. intertrial magazine entries | 0.6 | 0.8 | 1.3 | 1.1 | -1.0 | -0.9 | -1.0 | 1.0 | -0.8 | -1.0 | 1.0 | -1.0 | 1.0 | -1.0 | 0.8 | -0.3 | -0.9 | 1.0 | -0.9 | -0.3 | 0.9 | 0.7 | -0.9 | -1.0 | 1.1 | 1.0 | 1.1 | -0.9 | -1.0 | 1.0 | 0.3 |
Progressive ratio test 1 inactive lever presses | 0.6 | 0.7 | 4.0 | 0.2 | -0.2 | -0.5 | 0.5 | -0.5 | 0.5 | 0.8 | -0.6 | 0.7 | -0.7 | 0.7 | -0.5 | -1.3 | 0.6 | -0.7 | 0.8 | 1.3 | -0.9 | 2.0 | 0.9 | 0.7 | -0.5 | -0.5 | -0.6 | 1.0 | 0.7 | -0.7 | -0.9 |
Short access day 1 total inactive lever presses | 0.6 | 0.6 | 3.8 | 0.5 | -0.5 | -0.5 | -0.7 | 0.7 | -0.8 | -0.8 | 0.8 | -0.6 | 0.6 | -0.6 | 0.8 | -1.9 | -0.6 | 0.6 | 0.1 | 0.5 | 0.4 | 1.7 | -0.9 | -0.7 | 0.7 | 0.7 | 0.7 | -0.4 | -0.6 | 0.7 | -0.5 |
Locomotion velocity, NPP test | 0.6 | 0.8 | 8.3 | 0.9 | -1.0 | -1.5 | 0.3 | -0.3 | 0.3 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | -0.3 | -2.4 | 0.4 | -0.4 | 0.4 | 1.0 | -0.9 | 2.9 | 0.6 | 0.4 | -0.2 | -0.3 | 0.0 | 0.7 | 0.4 | -0.2 | -0.5 |
Pavlov. Cond. magazine entry number | 0.6 | 0.7 | 2.7 | 1.0 | -1.0 | -0.7 | -1.0 | 1.0 | -0.8 | -0.6 | 0.7 | -0.7 | 0.7 | -0.7 | 0.8 | 1.7 | -0.9 | 0.9 | -0.8 | -0.6 | 0.8 | -0.2 | -0.5 | -0.8 | 0.9 | 1.0 | 0.9 | -0.7 | -0.8 | 0.9 | 0.8 |
Bone: connectivity density | 0.6 | 0.9 | 3.0 | -0.1 | 0.1 | -0.1 | 0.9 | -0.9 | 1.1 | 1.1 | -0.9 | 0.9 | -0.9 | 0.9 | -1.1 | -0.9 | 0.8 | -0.9 | 1.0 | 1.7 | -0.9 | 1.3 | 1.2 | 0.8 | -0.7 | -0.6 | -0.4 | 1.1 | 0.8 | -0.8 | -1.2 |
Bone: cortical porosity | 0.6 | 0.7 | 4.8 | -1.5 | 1.6 | 1.9 | 0.4 | -0.4 | 0.4 | 0.3 | -0.5 | 0.4 | -0.4 | 0.4 | -0.4 | 1.4 | 0.4 | -0.5 | 0.5 | -0.4 | 0.0 | -2.2 | 0.1 | 0.4 | -0.5 | -0.5 | -0.7 | 0.1 | 0.4 | -0.4 | -0.0 |
Bone: cortical tissue density | 0.6 | 0.7 | 1.6 | -1.3 | 1.3 | 1.1 | 1.0 | -1.0 | 1.2 | 0.4 | -0.6 | 0.7 | -0.7 | 0.7 | -1.2 | 0.3 | 0.9 | -0.8 | 0.7 | -0.3 | -0.8 | -0.9 | 0.4 | 0.8 | -1.0 | -1.1 | -0.9 | 0.6 | 0.7 | -0.9 | -0.3 |
Bone: trabecular thickness | 0.6 | 0.7 | 1.3 | -0.3 | 0.3 | 0.2 | 0.9 | -0.9 | 1.0 | 1.1 | -0.9 | 1.0 | -1.0 | 1.0 | -1.0 | -0.2 | 0.8 | -0.8 | 1.0 | 1.1 | -1.0 | 0.8 | 1.1 | 0.8 | -0.8 | -0.8 | -0.6 | 0.9 | 0.8 | -0.8 | -0.9 |
Extinction: sum of active levers before priming | 0.6 | 0.6 | 1.2 | -0.9 | 0.9 | 0.7 | 0.7 | -0.7 | 0.7 | 0.9 | -0.9 | 1.1 | -1.1 | 1.1 | -0.7 | 0.6 | 0.8 | -0.8 | 0.7 | 0.0 | -0.6 | -0.8 | 0.9 | 0.8 | -0.7 | -0.7 | -0.8 | 0.6 | 0.8 | -1.0 | -0.1 |
Total resting periods, locomotor time 2 | 0.6 | 0.6 | 1.8 | -0.4 | 0.4 | 0.9 | -0.6 | 0.6 | -0.8 | -1.1 | 0.8 | -1.0 | 1.0 | -1.0 | 0.8 | 0.2 | -0.6 | 0.7 | -0.5 | -0.8 | 0.8 | -1.3 | -1.1 | -0.8 | 0.6 | 0.5 | 0.8 | -0.9 | -0.8 | 0.7 | 0.4 |
Number of licking bursts | 0.5 | 0.5 | 5.9 | -0.1 | 0.1 | 0.3 | -0.5 | 0.5 | -0.5 | -0.8 | 0.6 | -0.6 | 0.6 | -0.6 | 0.5 | -2.4 | -0.6 | 0.5 | -0.6 | 0.3 | 0.9 | 0.3 | -0.8 | -0.7 | 0.6 | 0.7 | 0.5 | -0.8 | -0.7 | 0.7 | -0.8 |
Indifference point AUC | 0.5 | 0.6 | 1.2 | -0.7 | 0.6 | 0.4 | 0.8 | -0.8 | 0.9 | 0.9 | -0.9 | 0.8 | -0.8 | 0.8 | -0.9 | -1.1 | 0.9 | -0.9 | 0.5 | 0.5 | -0.8 | 0.2 | 1.0 | 0.8 | -0.8 | -0.9 | -0.9 | 0.8 | 0.8 | -0.8 | -0.7 |
Delay discounting water rate 18 sec | 0.5 | 0.6 | 1.2 | -0.6 | 0.6 | 0.5 | 0.6 | -0.6 | 0.7 | 0.9 | -0.9 | 0.8 | -0.8 | 0.8 | -0.7 | -0.6 | 0.9 | -0.9 | 0.9 | 1.0 | -0.7 | -0.1 | 0.9 | 0.8 | -0.8 | -0.7 | -0.7 | 0.9 | 0.9 | -1.1 | -0.9 |
Delay discounting water rate 24 sec | 0.5 | 0.7 | 3.2 | -0.8 | 0.8 | 0.6 | 0.7 | -0.7 | 0.8 | 0.7 | -0.9 | 0.7 | -0.7 | 0.7 | -0.8 | -1.8 | 0.9 | -0.9 | 1.0 | 0.9 | -0.7 | 0.4 | 0.8 | 0.8 | -0.8 | -0.8 | -0.9 | 0.8 | 0.8 | -0.9 | -1.1 |
Pavlov. Cond. magazine entry number | 0.5 | 0.6 | 0.9 | 0.7 | -0.7 | -0.5 | -0.8 | 0.8 | -0.6 | -0.8 | 0.7 | -0.7 | 0.7 | -0.7 | 0.6 | 0.9 | -0.7 | 0.8 | -0.8 | -0.9 | 0.8 | -0.2 | -0.6 | -0.8 | 0.9 | 0.9 | 0.9 | -0.7 | -0.8 | 0.6 | 0.9 |
Intermitt. access day 1 inactive lever presses | 0.5 | 0.6 | 6.1 | 0.8 | -0.8 | -0.7 | -0.5 | 0.5 | -0.6 | 0.3 | 0.0 | 0.4 | -0.4 | 0.4 | 0.6 | -1.5 | 0.1 | -0.1 | 0.8 | 1.5 | -0.2 | 2.5 | 0.2 | 0.0 | 0.5 | 0.3 | 0.2 | 0.5 | 0.1 | 0.0 | -0.9 |
Intermittent access day 15 total locomotion | 0.5 | 0.6 | 6.1 | 1.0 | -1.0 | -1.1 | -0.4 | 0.4 | -0.3 | 0.5 | 0.0 | 0.5 | -0.5 | 0.5 | 0.3 | -1.1 | -0.0 | -0.0 | 0.6 | 1.4 | -0.3 | 2.5 | 0.3 | 0.0 | 0.4 | 0.4 | 0.3 | 0.5 | 0.1 | 0.1 | -0.8 |
Locomotion distance, session 1 | 0.5 | 0.6 | 1.8 | 0.4 | -0.4 | -0.6 | 0.7 | -0.7 | 0.8 | 1.0 | -0.7 | 0.6 | -0.6 | 0.6 | -0.8 | -0.2 | 0.7 | -0.7 | 0.8 | 1.3 | -1.0 | 1.3 | 1.1 | 0.8 | -0.6 | -0.6 | -0.3 | 1.0 | 0.8 | -0.7 | -0.7 |
Time in novel zone, hab. session 1 | 0.5 | 0.5 | 2.1 | 0.0 | -0.0 | -0.5 | 0.5 | -0.5 | 1.1 | 0.6 | -0.6 | 0.5 | -0.5 | 0.5 | -1.1 | -1.3 | 0.6 | -0.6 | 0.5 | 0.6 | -0.9 | 1.5 | 0.7 | 0.7 | -0.6 | -0.7 | -0.6 | 0.7 | 0.6 | -0.6 | -0.4 |
Novelty place preference | 0.5 | 0.5 | 0.9 | 0.9 | -0.9 | -0.9 | -0.8 | 0.8 | -0.5 | -0.6 | 0.8 | -0.8 | 0.8 | -0.8 | 0.5 | 0.1 | -0.7 | 0.8 | -0.8 | -0.3 | 0.7 | 0.4 | -0.6 | -0.7 | 0.7 | 0.9 | 0.7 | -0.6 | -0.7 | 0.7 | 0.5 |
Bone: cortical porosity | 0.5 | 0.5 | 5.4 | -1.1 | 1.1 | 1.5 | -0.0 | 0.0 | 0.1 | -0.2 | 0.0 | -0.1 | 0.1 | -0.1 | -0.1 | 1.7 | -0.1 | 0.1 | -0.1 | -1.0 | 0.5 | -2.3 | -0.4 | -0.1 | -0.1 | -0.0 | -0.3 | -0.4 | -0.1 | 0.1 | 0.6 |
Active lever presses in extinction session 6 | 0.5 | 0.5 | 1.3 | 0.8 | -0.8 | -1.1 | -0.9 | 0.9 | -0.9 | -0.5 | 0.6 | -0.4 | 0.4 | -0.4 | 0.9 | 0.7 | -0.6 | 0.6 | -0.3 | -0.5 | 0.6 | 0.5 | -0.6 | -0.5 | 1.0 | 0.9 | 0.5 | -0.5 | -0.6 | 0.5 | 0.7 |
Area under the delay curve | 0.5 | 0.6 | 1.1 | 0.3 | -0.3 | -0.2 | -0.9 | 0.9 | -1.0 | -0.9 | 0.9 | -0.8 | 0.8 | -0.8 | 1.0 | 0.8 | -0.7 | 0.8 | -0.4 | -0.9 | 0.7 | -0.1 | -1.0 | -0.7 | 0.8 | 0.7 | 0.5 | -0.7 | -0.7 | 1.0 | 0.6 |
Delay discount exponential model param | 0.5 | 0.5 | 1.0 | -0.3 | 0.3 | 0.1 | 0.8 | -0.8 | 0.9 | 0.8 | -0.9 | 0.8 | -0.8 | 0.8 | -0.9 | -0.9 | 0.7 | -0.8 | 0.4 | 0.9 | -0.7 | 0.2 | 1.0 | 0.6 | -0.7 | -0.7 | -0.4 | 0.7 | 0.7 | -0.9 | -0.6 |
Delay discount hyperbolic model param | 0.5 | 0.5 | 0.9 | -0.3 | 0.2 | 0.1 | 0.8 | -0.8 | 0.9 | 0.8 | -0.8 | 0.7 | -0.7 | 0.7 | -0.9 | -1.0 | 0.7 | -0.7 | 0.4 | 0.9 | -0.7 | 0.2 | 0.9 | 0.6 | -0.7 | -0.7 | -0.4 | 0.7 | 0.6 | -0.9 | -0.5 |
Liver weight, left | 0.4 | 0.6 | 3.7 | 1.3 | -1.4 | -1.7 | -0.5 | 0.5 | -0.3 | -0.4 | 0.6 | -0.6 | 0.6 | -0.6 | 0.3 | -1.8 | -0.5 | 0.5 | -0.5 | 0.5 | 0.1 | 1.9 | -0.3 | -0.4 | 0.5 | 0.5 | 0.4 | -0.1 | -0.3 | 0.4 | 0.2 |
Mean num. licks in bursts | 0.4 | 0.4 | 6.4 | 0.5 | -0.5 | -0.7 | 0.3 | -0.3 | 0.2 | 0.7 | -0.3 | 0.3 | -0.3 | 0.3 | -0.2 | 2.5 | 0.3 | -0.3 | 0.3 | -0.4 | -0.7 | -0.1 | 0.6 | 0.5 | -0.5 | -0.4 | -0.3 | 0.6 | 0.5 | -0.4 | 1.1 |
Std. dev. time between licks in bursts | 0.4 | 0.4 | 1.5 | -0.4 | 0.3 | 0.4 | 0.5 | -0.5 | 0.8 | 0.8 | -0.7 | 0.7 | -0.7 | 0.7 | -0.8 | -0.2 | 0.6 | -0.6 | 0.7 | 1.2 | -0.5 | 0.6 | 0.8 | 0.6 | -0.5 | -0.4 | -0.5 | 0.7 | 0.7 | -0.5 | -1.1 |
Delay discounting total patch changes 6 sec | 0.4 | 0.6 | 1.6 | 0.2 | -0.3 | -0.7 | 0.5 | -0.5 | 0.7 | 1.2 | -0.7 | 0.6 | -0.6 | 0.6 | -0.7 | -0.8 | 0.8 | -0.8 | 0.5 | 0.9 | -0.9 | 1.3 | 1.0 | 0.9 | -0.7 | -0.6 | -0.8 | 1.0 | 0.9 | -0.8 | -0.4 |
Delay discounting water rate 12 sec | 0.4 | 0.6 | 3.5 | 0.2 | -0.3 | -0.7 | 0.5 | -0.5 | 0.6 | 0.7 | -0.3 | 0.7 | -0.7 | 0.7 | -0.6 | -1.9 | 0.6 | -0.5 | 0.6 | 1.4 | -0.8 | 1.4 | 0.5 | 0.6 | -0.6 | -0.5 | -0.4 | 0.8 | 0.6 | -0.6 | -1.1 |
Locomotor activity | 0.4 | 0.6 | 1.1 | -0.7 | 0.7 | 0.6 | 0.5 | -0.5 | 0.7 | 0.8 | -0.8 | 0.8 | -0.8 | 0.8 | -0.7 | -0.2 | 0.8 | -0.8 | 1.0 | 1.0 | -0.7 | 0.6 | 0.8 | 0.7 | -0.5 | -0.5 | -0.6 | 0.9 | 0.8 | -0.9 | -1.1 |
Reaction time mean minus median AUC | 0.4 | 0.5 | 0.9 | 0.8 | -0.8 | -0.8 | -0.6 | 0.6 | -0.4 | -0.7 | 0.6 | -0.9 | 0.9 | -0.9 | 0.4 | -0.3 | -0.7 | 0.7 | -0.9 | -0.7 | 0.6 | 0.4 | -0.6 | -0.7 | 0.6 | 0.7 | 0.7 | -0.6 | -0.7 | 0.7 | 0.9 |
Social time | 0.4 | 0.6 | 1.0 | -0.7 | 0.7 | 0.6 | 0.9 | -0.9 | 0.6 | 0.8 | -0.9 | 0.8 | -0.8 | 0.8 | -0.6 | 0.8 | 0.7 | -0.7 | 1.0 | 0.4 | -1.0 | -0.3 | 0.9 | 0.8 | -0.7 | -1.0 | -0.7 | 0.8 | 0.8 | -0.7 | -0.2 |
Intermittent access total locomotion | 0.4 | 0.5 | 4.1 | 0.7 | -0.7 | -0.7 | -0.5 | 0.5 | -0.4 | 0.1 | 0.3 | 0.3 | -0.3 | 0.3 | 0.4 | -1.7 | -0.3 | 0.2 | 0.3 | 1.3 | 0.1 | 2.0 | -0.1 | -0.3 | 0.5 | 0.6 | 0.4 | 0.1 | -0.2 | 0.4 | -1.0 |
One hour access (0.3 mA shock) | 0.4 | 0.4 | 3.9 | 0.4 | -0.4 | -0.3 | -0.1 | 0.1 | -0.1 | 0.4 | -0.2 | 0.8 | -0.8 | 0.8 | 0.1 | -1.4 | 0.2 | -0.2 | 0.7 | 1.4 | -0.2 | 2.0 | 0.3 | 0.1 | 0.2 | 0.2 | 0.2 | 0.5 | 0.2 | -0.1 | -1.0 |
Context. condit. distance diff. score | 0.4 | 0.5 | 3.7 | 0.7 | -0.7 | -0.9 | 0.1 | -0.1 | 0.4 | 0.4 | -0.1 | 0.1 | -0.1 | 0.1 | -0.4 | -1.8 | 0.1 | -0.2 | 0.2 | 1.4 | -0.5 | 1.9 | 0.4 | 0.2 | -0.2 | -0.2 | -0.1 | 0.5 | 0.3 | -0.2 | -1.0 |
Locomotion velocity, session 8 | 0.4 | 0.5 | 1.5 | 0.2 | -0.2 | -0.2 | 0.6 | -0.6 | 0.8 | 1.0 | -0.6 | 0.7 | -0.7 | 0.7 | -0.8 | 0.1 | 0.6 | -0.6 | 0.7 | 1.2 | -0.8 | 0.8 | 1.0 | 0.7 | -0.6 | -0.5 | -0.5 | 0.9 | 0.8 | -0.6 | -0.5 |
Condit. Reinf. active responses | 0.4 | 0.5 | 1.0 | -0.9 | 0.9 | 0.7 | 0.9 | -0.9 | 0.6 | 0.5 | -0.8 | 0.6 | -0.6 | 0.6 | -0.6 | -0.8 | 0.8 | -0.8 | 0.7 | 0.3 | -0.8 | -0.1 | 0.6 | 0.8 | -0.9 | -1.0 | -0.8 | 0.7 | 0.7 | -0.9 | -0.5 |
Incentive salience index mean | 0.4 | 0.4 | 1.7 | -0.5 | 0.5 | 0.2 | 0.7 | -0.7 | 0.6 | 0.5 | -0.6 | 0.6 | -0.6 | 0.6 | -0.6 | -1.3 | 0.7 | -0.6 | 0.7 | 0.5 | -0.9 | 0.8 | 0.5 | 0.7 | -0.7 | -0.9 | -0.6 | 0.7 | 0.6 | -0.7 | -0.5 |
Total zone transitions, hab. session 1 | 0.4 | 0.5 | 1.4 | 0.1 | -0.1 | -0.4 | 0.7 | -0.7 | 0.6 | 0.7 | -0.7 | 0.7 | -0.7 | 0.7 | -0.6 | -0.8 | 0.7 | -0.7 | 0.9 | 1.0 | -1.0 | 1.2 | 0.8 | 0.7 | -0.6 | -0.6 | -0.3 | 0.9 | 0.7 | -0.8 | -0.6 |
Total locomotion distance, hab. session 1 | 0.4 | 0.5 | 4.4 | 0.7 | -0.7 | -1.2 | 0.5 | -0.5 | 0.1 | 0.5 | -0.4 | 0.4 | -0.4 | 0.4 | -0.1 | -1.3 | 0.5 | -0.5 | 0.5 | 0.9 | -0.9 | 2.1 | 0.7 | 0.5 | -0.4 | -0.4 | -0.0 | 0.8 | 0.5 | -0.5 | -0.4 |
Locomotion velocity, hab. session 1 | 0.4 | 0.6 | 5.0 | 0.6 | -0.6 | -1.1 | 0.6 | -0.6 | 0.2 | 0.5 | -0.4 | 0.4 | -0.4 | 0.4 | -0.2 | -1.6 | 0.6 | -0.5 | 0.6 | 0.9 | -1.0 | 2.2 | 0.6 | 0.6 | -0.5 | -0.5 | -0.1 | 0.9 | 0.6 | -0.5 | -0.5 |
Total zone transitions, NPP test | 0.4 | 0.5 | 3.1 | -0.4 | 0.4 | 0.3 | 0.7 | -0.7 | 0.5 | 0.5 | -0.7 | 0.7 | -0.7 | 0.7 | -0.5 | -1.7 | 0.7 | -0.7 | 0.8 | 0.9 | -0.7 | 1.0 | 0.7 | 0.6 | -0.5 | -0.5 | -0.3 | 0.7 | 0.6 | -0.6 | -0.9 |
Pavlov. Cond. lever latency | 0.4 | 0.5 | 2.0 | -1.1 | 1.1 | 1.3 | 0.7 | -0.7 | 0.4 | 0.5 | -0.7 | 0.6 | -0.6 | 0.6 | -0.4 | 0.8 | 0.7 | -0.7 | 0.4 | 0.2 | -0.3 | -1.4 | 0.5 | 0.6 | -0.6 | -0.6 | -0.8 | 0.4 | 0.6 | -0.7 | -0.5 |
Pavlov. Cond. response bias | 0.4 | 0.5 | 2.3 | -0.4 | 0.4 | 0.1 | 0.7 | -0.7 | 0.7 | 0.6 | -0.5 | 0.6 | -0.6 | 0.6 | -0.7 | -1.5 | 0.7 | -0.6 | 0.6 | 0.7 | -0.7 | 0.8 | 0.5 | 0.6 | -0.7 | -0.7 | -0.6 | 0.7 | 0.6 | -0.7 | -0.7 |
Bone: cortical thickness | 0.4 | 0.4 | 0.9 | -0.7 | 0.7 | 0.7 | 0.7 | -0.7 | 0.9 | 0.6 | -0.6 | 0.7 | -0.7 | 0.7 | -0.9 | 0.1 | 0.6 | -0.6 | 0.7 | 0.4 | -0.5 | -0.6 | 0.6 | 0.6 | -0.6 | -0.6 | -0.7 | 0.6 | 0.6 | -0.7 | -0.6 |
Bone: maximum force | 0.4 | 0.7 | 1.6 | -0.3 | 0.3 | -0.0 | 0.8 | -0.8 | 0.9 | 0.8 | -0.8 | 0.7 | -0.7 | 0.7 | -0.9 | -1.1 | 0.8 | -0.8 | 0.7 | 0.9 | -1.0 | 1.3 | 0.8 | 0.8 | -0.8 | -0.9 | -1.0 | 0.9 | 0.8 | -0.8 | -1.0 |
Delta distance traveled before/after self-admin | 0.4 | 0.4 | 3.5 | -0.9 | 0.9 | 1.1 | 0.7 | -0.7 | 0.7 | 0.3 | -0.6 | 0.1 | -0.1 | 0.1 | -0.7 | 0.3 | 0.5 | -0.5 | -0.3 | -0.2 | -0.2 | -1.9 | 0.5 | 0.5 | -0.7 | -0.7 | -0.4 | 0.2 | 0.4 | -0.6 | -0.0 |
Time in closed arm before self-admin | 0.4 | 0.4 | 1.0 | 0.3 | -0.3 | 0.0 | -0.7 | 0.7 | -0.7 | -0.6 | 0.6 | -0.4 | 0.4 | -0.4 | 0.7 | 0.8 | -0.5 | 0.6 | -0.9 | -0.9 | 0.9 | -1.0 | -0.6 | -0.6 | 0.7 | 0.7 | 0.5 | -0.7 | -0.6 | 0.5 | 0.7 |
Delay disc. indifference point, 8s delay | 0.4 | 0.5 | 1.1 | 0.0 | 0.0 | 0.2 | -0.8 | 0.8 | -0.9 | -0.8 | 0.9 | -0.6 | 0.6 | -0.6 | 0.9 | 0.4 | -0.7 | 0.8 | -0.2 | -0.7 | 0.8 | -0.3 | -1.1 | -0.7 | 0.7 | 0.8 | 0.5 | -0.8 | -0.7 | 0.9 | 0.2 |
Food seeking constrained by brief footshock | 0.4 | 0.5 | 4.1 | 0.9 | -0.9 | -1.4 | 0.2 | -0.2 | 0.2 | 0.7 | -0.3 | 0.7 | -0.7 | 0.7 | -0.2 | -0.3 | 0.3 | -0.3 | 0.3 | 0.7 | -0.7 | 2.0 | 0.7 | 0.5 | -0.3 | -0.3 | -0.5 | 0.7 | 0.5 | -0.1 | -0.1 |
Sr content in liver | 0.4 | 0.3 | 1.4 | -0.6 | 0.6 | 0.5 | 0.4 | -0.4 | 0.4 | 0.4 | -0.5 | 0.5 | -0.5 | 0.5 | -0.4 | -1.2 | 0.5 | -0.5 | 0.5 | 0.9 | -0.4 | 0.4 | 0.3 | 0.5 | -0.6 | -0.5 | -0.7 | 0.5 | 0.6 | -0.4 | -1.2 |
Locomotor testing rearing | 0.3 | 0.5 | 2.3 | 0.1 | -0.1 | -0.7 | 0.7 | -0.7 | 0.6 | 0.8 | -0.7 | 0.4 | -0.4 | 0.4 | -0.6 | -0.4 | 0.7 | -0.7 | 0.8 | 0.9 | -1.0 | 1.5 | 0.9 | 0.8 | -0.6 | -0.6 | -0.7 | 1.0 | 0.8 | -0.7 | -0.7 |
Intermitt. access escalation Index | 0.3 | 0.3 | 2.7 | -0.4 | 0.5 | 0.7 | -0.1 | 0.1 | -0.1 | -0.4 | 0.1 | -0.5 | 0.5 | -0.5 | 0.1 | 0.9 | -0.1 | 0.1 | -0.5 | -0.7 | 0.5 | -1.6 | -0.3 | -0.2 | 0.2 | 0.2 | 0.2 | -0.4 | -0.2 | 0.1 | 0.5 |
Intermittent access day 1 total infusions | 0.3 | 0.3 | 0.5 | 0.2 | -0.2 | -0.2 | -0.4 | 0.4 | -0.4 | -0.7 | 0.6 | -0.7 | 0.7 | -0.7 | 0.4 | -0.5 | -0.6 | 0.5 | -0.7 | -0.7 | 0.6 | -0.4 | -0.6 | -0.5 | 0.4 | 0.5 | 0.4 | -0.6 | -0.6 | 0.6 | 0.5 |
Intermittent access day 15 total infusions | 0.3 | 0.3 | 2.4 | 0.1 | -0.1 | 0.0 | -0.0 | 0.0 | -0.1 | 0.4 | -0.2 | 0.6 | -0.6 | 0.6 | 0.1 | -1.5 | 0.3 | -0.3 | 0.6 | 1.4 | -0.2 | 1.5 | 0.2 | 0.1 | 0.0 | 0.0 | 0.0 | 0.4 | 0.3 | -0.2 | -1.2 |
Intermittent access terminal intake (last 3 days) | 0.3 | 0.3 | 3.4 | 0.5 | -0.5 | -0.6 | -0.1 | 0.1 | 0.0 | 0.3 | -0.0 | 0.5 | -0.5 | 0.5 | -0.0 | -1.5 | 0.1 | -0.1 | 0.4 | 1.2 | -0.2 | 1.8 | 0.2 | 0.0 | 0.1 | 0.1 | 0.1 | 0.4 | 0.1 | -0.0 | -0.8 |
Short access day 10 total locomotion | 0.3 | 0.3 | 1.3 | -0.4 | 0.4 | 0.4 | 0.1 | -0.1 | 0.3 | 0.6 | -0.3 | 0.9 | -0.9 | 0.9 | -0.3 | -1.0 | 0.3 | -0.4 | 0.9 | 1.2 | -0.3 | 0.6 | 0.4 | 0.3 | -0.2 | -0.1 | -0.2 | 0.5 | 0.4 | -0.3 | -1.1 |
One hour access (shock baseline) | 0.3 | 0.3 | 0.7 | -0.0 | 0.0 | -0.1 | 0.6 | -0.6 | 0.5 | 0.7 | -0.7 | 0.7 | -0.7 | 0.7 | -0.5 | -0.6 | 0.6 | -0.6 | 0.5 | 0.8 | -0.7 | 0.7 | 0.8 | 0.6 | -0.5 | -0.5 | -0.5 | 0.7 | 0.6 | -0.6 | -0.6 |
Stereotopy head waving bouts, day 7 | 0.3 | 0.3 | 1.4 | -0.8 | 0.8 | 0.7 | 0.5 | -0.5 | 0.2 | 0.4 | -0.3 | 0.4 | -0.4 | 0.4 | -0.2 | 1.2 | 0.4 | -0.4 | 0.4 | -0.1 | -0.3 | -1.0 | 0.2 | 0.6 | -0.5 | -0.6 | -0.9 | 0.3 | 0.5 | -0.4 | -0.1 |
Stereotopy head waving duration, day 7 | 0.3 | 0.3 | 3.5 | -0.7 | 0.7 | 0.8 | 0.1 | -0.1 | -0.2 | 0.1 | -0.0 | 0.1 | -0.1 | 0.1 | 0.2 | 1.9 | 0.1 | -0.0 | 0.1 | -0.6 | 0.1 | -1.7 | -0.1 | 0.2 | -0.1 | -0.2 | -0.5 | -0.1 | 0.2 | -0.1 | 0.3 |
Novel to familiar place preference ratio | 0.3 | 0.3 | 1.0 | 0.9 | -0.9 | -1.0 | -0.6 | 0.6 | -0.3 | -0.5 | 0.6 | -0.6 | 0.6 | -0.6 | 0.3 | -0.2 | -0.5 | 0.6 | -0.6 | -0.1 | 0.5 | 0.6 | -0.4 | -0.5 | 0.5 | 0.7 | 0.4 | -0.4 | -0.5 | 0.5 | 0.3 |
Time in novel zone, NPP test | 0.3 | 0.3 | 0.7 | 0.8 | -0.8 | -0.9 | -0.7 | 0.7 | -0.4 | -0.5 | 0.6 | -0.6 | 0.6 | -0.6 | 0.4 | -0.1 | -0.6 | 0.6 | -0.7 | -0.2 | 0.6 | 0.4 | -0.5 | -0.6 | 0.5 | 0.7 | 0.5 | -0.5 | -0.5 | 0.5 | 0.4 |
Pavlov. Cond. magazine entry latency | 0.3 | 0.4 | 4.4 | 0.0 | -0.0 | -0.4 | 0.6 | -0.6 | 0.5 | 0.3 | -0.4 | 0.4 | -0.4 | 0.4 | -0.5 | -2.1 | 0.5 | -0.5 | 0.5 | 0.6 | -0.7 | 1.4 | 0.4 | 0.5 | -0.5 | -0.5 | -0.2 | 0.6 | 0.4 | -0.5 | -0.5 |
Pavlov. Cond. intertrial magazine entries | 0.3 | 0.3 | 0.8 | -0.4 | 0.4 | 0.5 | 0.4 | -0.4 | 0.3 | 0.7 | -0.7 | 0.6 | -0.6 | 0.6 | -0.3 | 0.8 | 0.6 | -0.6 | 0.6 | 0.9 | -0.5 | -0.3 | 0.8 | 0.5 | -0.5 | -0.5 | -0.3 | 0.6 | 0.6 | -0.5 | -0.6 |
Bone: elastic displacement | 0.3 | 0.3 | 2.7 | -1.1 | 1.1 | 1.4 | 0.3 | -0.3 | 0.3 | -0.1 | -0.3 | 0.2 | -0.2 | 0.2 | -0.3 | 0.8 | 0.3 | -0.3 | 0.2 | -0.1 | 0.1 | -1.6 | 0.1 | 0.1 | -0.3 | -0.3 | -0.0 | -0.1 | 0.1 | -0.3 | -0.4 |
Bone: endosteal estimation | 0.3 | 0.6 | 1.8 | -0.3 | 0.3 | 0.0 | 0.8 | -0.8 | 0.6 | 0.8 | -0.7 | 0.6 | -0.6 | 0.6 | -0.6 | -1.3 | 0.8 | -0.8 | 0.4 | 1.3 | -0.9 | 0.7 | 0.8 | 0.8 | -0.9 | -0.9 | -1.1 | 0.8 | 0.8 | -0.7 | -1.2 |
Bone: marrow area | 0.3 | 0.6 | 1.7 | -0.3 | 0.2 | -0.1 | 0.7 | -0.7 | 0.6 | 0.7 | -0.7 | 0.5 | -0.5 | 0.5 | -0.6 | -1.3 | 0.7 | -0.7 | 0.4 | 1.3 | -0.8 | 0.8 | 0.8 | 0.8 | -0.8 | -0.8 | -1.0 | 0.8 | 0.8 | -0.7 | -1.2 |
Diff in mean of infusions in LGA sessions | 0.3 | 0.4 | 4.7 | -0.4 | 0.4 | 0.4 | 0.2 | -0.2 | 0.2 | -0.2 | -0.3 | 0.0 | -0.0 | 0.0 | -0.2 | 0.6 | 0.2 | -0.2 | -0.9 | -1.4 | 0.3 | -2.2 | 0.2 | -0.1 | -0.0 | -0.1 | 0.1 | -0.4 | -0.2 | -0.4 | 1.0 |
Time in open arm before self-admin | 0.3 | 0.3 | 0.6 | 0.1 | -0.1 | 0.1 | -0.8 | 0.8 | -0.8 | -0.6 | 0.4 | -0.7 | 0.7 | -0.7 | 0.8 | -0.6 | -0.5 | 0.5 | -0.5 | -0.4 | 0.8 | -0.3 | -0.5 | -0.6 | 0.5 | 0.8 | 0.5 | -0.6 | -0.5 | 0.5 | 0.2 |
Time in open arm after self-admin | 0.3 | 0.3 | 2.9 | 0.6 | -0.6 | -0.8 | 0.1 | -0.1 | 0.1 | 0.5 | -0.1 | 0.5 | -0.5 | 0.5 | -0.1 | -0.7 | 0.3 | -0.2 | 0.6 | 1.2 | -0.4 | 1.7 | 0.3 | 0.3 | -0.1 | -0.1 | -0.1 | 0.6 | 0.4 | -0.2 | -0.7 |
Run reversals in cocaine runway, females | 0.3 | 0.3 | 1.6 | 0.2 | -0.3 | -0.2 | 0.5 | -0.5 | 0.5 | 0.5 | -0.3 | 0.4 | -0.4 | 0.4 | -0.5 | -0.5 | 0.2 | -0.3 | 0.5 | 1.3 | -0.6 | 1.0 | 0.6 | 0.2 | -0.4 | -0.4 | 0.1 | 0.5 | 0.3 | -0.2 | -0.8 |
K content in liver | 0.3 | 0.3 | 0.6 | -0.4 | 0.4 | 0.3 | 0.6 | -0.6 | 0.4 | 0.6 | -0.6 | 0.8 | -0.8 | 0.8 | -0.4 | 0.1 | 0.5 | -0.6 | 0.8 | 0.4 | -0.7 | -0.1 | 0.6 | 0.6 | -0.5 | -0.7 | -0.5 | 0.6 | 0.6 | -0.6 | -0.0 |
Glucose | 0.2 | 0.3 | 0.7 | -0.1 | 0.1 | 0.1 | 0.5 | -0.5 | 0.8 | 0.7 | -0.4 | 0.4 | -0.4 | 0.4 | -0.8 | -0.2 | 0.5 | -0.5 | 0.3 | 0.9 | -0.5 | 0.3 | 0.6 | 0.5 | -0.5 | -0.5 | -0.6 | 0.6 | 0.5 | -0.5 | -0.7 |
Parametrial fat weight | 0.2 | 0.4 | 1.0 | 0.3 | -0.3 | 0.0 | -0.6 | 0.6 | -0.6 | -0.6 | 0.7 | -0.8 | 0.8 | -0.8 | 0.6 | -0.4 | -0.5 | 0.6 | -1.0 | -0.6 | 0.7 | -0.3 | -0.8 | -0.6 | 0.6 | 0.6 | 0.4 | -0.7 | -0.6 | 0.4 | 0.3 |
Delay discounting total patch changes 0 sec | 0.2 | 0.3 | 2.0 | 0.9 | -0.9 | -1.3 | 0.0 | -0.0 | 0.3 | 0.6 | -0.0 | 0.1 | -0.1 | 0.1 | -0.3 | 0.1 | 0.1 | -0.1 | 0.1 | 0.4 | -0.4 | 1.4 | 0.3 | 0.3 | -0.1 | 0.0 | -0.4 | 0.5 | 0.3 | -0.1 | 0.3 |
Delay discounting total patch changes 12 sec | 0.2 | 0.2 | 1.0 | -0.3 | 0.3 | 0.2 | 0.3 | -0.3 | 0.6 | 0.7 | -0.5 | 0.3 | -0.3 | 0.3 | -0.6 | 1.0 | 0.5 | -0.5 | 0.2 | -0.1 | -0.3 | -0.5 | 0.5 | 0.6 | -0.4 | -0.3 | -0.6 | 0.4 | 0.5 | -0.5 | 0.2 |
Reaction time trials on left | 0.2 | 0.2 | 0.9 | 0.2 | -0.2 | -0.6 | 0.4 | -0.4 | 0.6 | 0.7 | -0.4 | 0.4 | -0.4 | 0.4 | -0.6 | 0.2 | 0.2 | -0.3 | 0.2 | 0.3 | -0.6 | 0.4 | 0.6 | 0.5 | -0.4 | -0.5 | -1.0 | 0.5 | 0.5 | -0.2 | -0.1 |
Median of all reaction times | 0.2 | 0.2 | 1.0 | -0.3 | 0.3 | 0.3 | 0.3 | -0.3 | 0.4 | 0.3 | -0.4 | 0.5 | -0.5 | 0.5 | -0.4 | -1.0 | 0.2 | -0.3 | 0.4 | 0.7 | -0.3 | 1.0 | 0.4 | 0.2 | -0.2 | -0.3 | -0.3 | 0.3 | 0.3 | -0.2 | -0.8 |
Std. dev. reaction times | 0.2 | 0.3 | 2.4 | -0.6 | 0.6 | 0.4 | 0.5 | -0.5 | 0.5 | 0.2 | -0.6 | 0.2 | -0.2 | 0.2 | -0.5 | -1.6 | 0.4 | -0.5 | 0.2 | 0.3 | -0.4 | 0.7 | 0.4 | 0.4 | -0.4 | -0.5 | -0.5 | 0.3 | 0.3 | -0.4 | -0.5 |
Reaction time trials completed | 0.2 | 0.2 | 0.9 | 0.2 | -0.2 | -0.6 | 0.4 | -0.4 | 0.6 | 0.7 | -0.4 | 0.4 | -0.4 | 0.4 | -0.6 | 0.2 | 0.2 | -0.3 | 0.2 | 0.3 | -0.6 | 0.4 | 0.6 | 0.5 | -0.4 | -0.5 | -1.0 | 0.5 | 0.5 | -0.2 | -0.1 |
Reaction time trials AUC | 0.2 | 0.2 | 1.0 | 0.2 | -0.2 | -0.6 | 0.5 | -0.5 | 0.6 | 0.7 | -0.5 | 0.4 | -0.4 | 0.4 | -0.6 | 0.3 | 0.2 | -0.3 | 0.1 | 0.3 | -0.6 | 0.3 | 0.6 | 0.6 | -0.4 | -0.6 | -1.0 | 0.5 | 0.5 | -0.3 | -0.1 |
Conditioned reinforcement - actives | 0.2 | 0.2 | 1.3 | -0.1 | 0.1 | 0.2 | -0.0 | 0.0 | -0.0 | 0.4 | -0.1 | 0.6 | -0.6 | 0.6 | 0.0 | -1.0 | 0.1 | -0.2 | 0.8 | 1.1 | -0.1 | 1.1 | 0.2 | 0.1 | 0.0 | 0.1 | -0.1 | 0.4 | 0.2 | -0.1 | -1.0 |
Conditioned locomotion | 0.2 | 0.3 | 1.4 | 0.4 | -0.4 | -0.2 | -0.6 | 0.6 | -0.5 | -0.0 | 0.5 | 0.1 | -0.1 | 0.1 | 0.5 | -0.6 | -0.5 | 0.4 | 0.3 | 0.8 | 0.3 | 1.2 | -0.5 | -0.4 | 0.5 | 0.6 | 0.4 | -0.1 | -0.3 | 0.6 | -0.7 |
Intermittent access intake escalation 2 | 0.2 | 0.2 | 1.9 | 0.2 | -0.2 | 0.1 | -0.3 | 0.3 | -0.3 | 0.1 | 0.0 | 0.5 | -0.5 | 0.5 | 0.3 | -0.8 | 0.1 | -0.1 | 0.6 | 1.2 | 0.0 | 1.4 | 0.0 | -0.2 | 0.3 | 0.3 | 0.5 | 0.2 | -0.1 | 0.0 | -1.0 |
Intermittent access total infusions | 0.2 | 0.2 | 1.8 | 0.6 | -0.6 | -0.7 | -0.3 | 0.3 | -0.2 | -0.2 | 0.3 | -0.0 | 0.0 | -0.0 | 0.2 | -1.2 | -0.3 | 0.3 | -0.1 | 0.5 | 0.1 | 1.3 | -0.2 | -0.3 | 0.3 | 0.3 | 0.3 | -0.1 | -0.2 | 0.3 | -0.3 |
Intermittent access day 1 locomotion | 0.2 | 0.2 | 1.4 | 0.4 | -0.4 | -0.4 | -0.4 | 0.4 | -0.4 | -0.1 | 0.4 | -0.0 | 0.0 | -0.0 | 0.4 | -1.2 | -0.3 | 0.3 | -0.1 | 0.5 | 0.3 | 0.7 | -0.2 | -0.3 | 0.4 | 0.5 | 0.3 | -0.2 | -0.2 | 0.4 | -0.4 |
Intermittent access standard deviation | 0.2 | 0.2 | 1.8 | -0.3 | 0.3 | 0.2 | 0.3 | -0.3 | 0.2 | 0.2 | -0.2 | 0.3 | -0.3 | 0.3 | -0.2 | -1.3 | 0.3 | -0.3 | 0.4 | 0.7 | -0.3 | 0.9 | 0.2 | 0.2 | -0.3 | -0.3 | -0.2 | 0.3 | 0.2 | -0.2 | -0.8 |
Progressive ratio test 2 active lever presses | 0.2 | 0.3 | 1.9 | 0.3 | -0.3 | -0.5 | 0.2 | -0.2 | 0.2 | 0.5 | -0.4 | 0.5 | -0.5 | 0.5 | -0.2 | -0.9 | 0.3 | -0.4 | 0.4 | 0.9 | -0.4 | 1.4 | 0.5 | 0.3 | -0.2 | -0.2 | -0.2 | 0.5 | 0.3 | -0.3 | -0.5 |
Locomotion velocity, session 1 | 0.2 | 0.2 | 0.8 | -0.1 | 0.1 | -0.1 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.4 | -0.4 | 0.4 | -0.4 | 0.9 | 0.4 | -0.4 | 0.4 | -0.4 | -0.4 | -0.2 | 0.5 | 0.5 | -0.4 | -0.2 | -0.6 | 0.5 | 0.5 | -0.4 | 0.5 |
Pavlov. Cond. latency score | 0.2 | 0.3 | 2.3 | 0.8 | -0.8 | -1.2 | -0.3 | 0.3 | -0.2 | -0.3 | 0.3 | -0.3 | 0.3 | -0.3 | 0.2 | -1.4 | -0.3 | 0.3 | -0.2 | -0.1 | -0.1 | 1.5 | -0.3 | -0.3 | 0.2 | 0.2 | 0.4 | -0.1 | -0.3 | 0.2 | 0.3 |
Bone: tissue strength | 0.2 | 0.2 | 1.5 | 0.1 | -0.1 | -0.4 | 0.3 | -0.3 | 0.1 | 0.2 | -0.3 | 0.3 | -0.3 | 0.3 | -0.1 | -1.0 | 0.3 | -0.3 | 0.2 | 0.3 | -0.4 | 1.2 | 0.3 | 0.3 | -0.3 | -0.3 | -0.4 | 0.4 | 0.3 | -0.2 | -0.4 |
Bone: trabecular spacing | 0.2 | 0.2 | 1.3 | 0.1 | -0.1 | -0.2 | -0.4 | 0.4 | -0.4 | -0.6 | 0.4 | -0.4 | 0.4 | -0.4 | 0.4 | 0.2 | -0.3 | 0.4 | -0.5 | -1.1 | 0.3 | -0.6 | -0.5 | -0.4 | 0.3 | 0.2 | 0.3 | -0.5 | -0.4 | 0.3 | 0.7 |
Delta time in closed arm before/after self-admin | 0.2 | 0.2 | 0.5 | 0.2 | -0.2 | -0.4 | -0.3 | 0.3 | -0.3 | -0.5 | 0.3 | -0.7 | 0.7 | -0.7 | 0.3 | 0.4 | -0.4 | 0.4 | -0.6 | -0.7 | 0.4 | -0.5 | -0.3 | -0.4 | 0.2 | 0.3 | 0.4 | -0.5 | -0.5 | 0.4 | 0.6 |
Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.4 | 0.2 | -0.2 | -0.3 | -0.4 | 0.4 | -0.6 | -0.3 | 0.4 | -0.5 | 0.5 | -0.5 | 0.6 | 0.6 | -0.3 | 0.4 | -0.4 | -0.6 | 0.4 | -0.4 | -0.4 | -0.3 | 0.3 | 0.3 | 0.1 | -0.4 | -0.3 | 0.6 | 0.4 |
Fecal boli incidents, locomotor time 1 | 0.2 | 0.2 | 1.1 | -0.6 | 0.6 | 0.8 | 0.1 | -0.1 | 0.2 | 0.3 | -0.4 | 0.5 | -0.5 | 0.5 | -0.2 | 0.9 | 0.3 | -0.3 | 0.2 | -0.0 | 0.1 | -1.1 | 0.3 | 0.3 | -0.1 | -0.0 | -0.4 | 0.1 | 0.2 | -0.2 | -0.1 |
Time >=10cm from walls, locomotor time 1 | 0.2 | 0.2 | 1.1 | -0.7 | 0.7 | 1.1 | 0.2 | -0.2 | 0.3 | 0.4 | -0.4 | 0.4 | -0.4 | 0.4 | -0.3 | -0.3 | 0.4 | -0.4 | 0.7 | 0.6 | -0.0 | -0.4 | 0.4 | 0.3 | -0.2 | -0.1 | -0.4 | 0.3 | 0.4 | -0.3 | -0.7 |
Rest time, locomotor task time 1 | 0.2 | 0.3 | 1.1 | -0.1 | 0.1 | 0.3 | -0.4 | 0.4 | -0.3 | -0.6 | 0.2 | -0.7 | 0.7 | -0.7 | 0.3 | 0.7 | -0.2 | 0.3 | -0.6 | -0.9 | 0.5 | -1.1 | -0.4 | -0.4 | 0.3 | 0.4 | 0.5 | -0.5 | -0.4 | 0.2 | 0.7 |
Rest time, locomotor task time 2 | 0.2 | 0.2 | 1.2 | -0.5 | 0.5 | 0.9 | -0.4 | 0.4 | -0.3 | -0.4 | 0.1 | -0.2 | 0.2 | -0.2 | 0.3 | 1.1 | -0.1 | 0.1 | 0.0 | -0.7 | 0.4 | -0.8 | -0.3 | -0.3 | 0.3 | 0.3 | 0.3 | -0.4 | -0.4 | 0.2 | 0.4 |
Distance moved, locomotor task time 2 | 0.2 | 0.2 | 1.4 | 1.0 | -1.0 | -1.2 | -0.0 | 0.0 | -0.0 | 0.1 | 0.2 | -0.2 | 0.2 | -0.2 | 0.0 | 0.5 | -0.4 | 0.4 | -0.5 | -0.0 | 0.0 | 0.3 | 0.2 | -0.2 | 0.1 | 0.2 | 0.3 | -0.1 | -0.2 | 0.2 | 0.5 |
Vertical activity count, locomotor time 2 | 0.2 | 0.2 | 1.3 | 0.8 | -0.8 | -1.1 | 0.3 | -0.3 | 0.3 | 0.7 | -0.1 | 0.3 | -0.3 | 0.3 | -0.3 | 0.5 | -0.1 | 0.0 | -0.1 | 0.5 | -0.4 | 0.3 | 0.6 | 0.2 | -0.3 | -0.3 | -0.2 | 0.3 | 0.2 | -0.2 | 0.1 |
Cd content in liver | 0.2 | 0.2 | 0.6 | -0.2 | 0.2 | 0.2 | 0.4 | -0.4 | 0.3 | 0.5 | -0.6 | 0.7 | -0.7 | 0.7 | -0.3 | -0.3 | 0.5 | -0.5 | 0.6 | 0.7 | -0.4 | 0.7 | 0.7 | 0.2 | -0.3 | -0.3 | 0.4 | 0.4 | 0.2 | -0.4 | -0.8 |
Na content in liver | 0.2 | 0.2 | 0.5 | 0.6 | -0.6 | -0.7 | -0.3 | 0.3 | -0.3 | -0.6 | 0.5 | -0.6 | 0.6 | -0.6 | 0.3 | -0.3 | -0.5 | 0.5 | -0.4 | -0.5 | 0.2 | 0.3 | -0.4 | -0.4 | 0.3 | 0.2 | 0.4 | -0.3 | -0.4 | 0.2 | 0.7 |
Zn content in liver | 0.2 | 0.3 | 0.9 | 0.1 | -0.2 | -0.6 | 0.5 | -0.5 | 0.6 | 0.5 | -0.5 | 0.5 | -0.5 | 0.5 | -0.6 | -0.5 | 0.4 | -0.4 | 0.5 | 0.2 | -0.8 | 1.0 | 0.5 | 0.5 | -0.6 | -0.5 | -0.5 | 0.6 | 0.5 | -0.4 | 0.0 |
Liver weight, right | 0.1 | 0.1 | 1.3 | 0.0 | -0.0 | -0.3 | -0.2 | 0.2 | -0.2 | -0.5 | 0.1 | -0.2 | 0.2 | -0.2 | 0.2 | -1.1 | -0.2 | 0.1 | -0.2 | -0.5 | 0.2 | 0.4 | -0.3 | -0.2 | 0.2 | 0.2 | -0.0 | -0.3 | -0.2 | 0.1 | 0.2 |
Retroperitoneal fat weight | 0.1 | 0.3 | 1.1 | 0.5 | -0.5 | -0.6 | -0.4 | 0.4 | -0.3 | -0.7 | 0.7 | -0.6 | 0.6 | -0.6 | 0.3 | -1.0 | -0.5 | 0.5 | -0.3 | 0.0 | 0.3 | 1.1 | -0.7 | -0.5 | 0.4 | 0.3 | 0.4 | -0.4 | -0.5 | 0.5 | -0.0 |
Intraocular pressure | 0.1 | 0.1 | 0.8 | -0.6 | 0.6 | 0.9 | 0.1 | -0.1 | -0.1 | 0.2 | -0.3 | 0.4 | -0.4 | 0.4 | 0.1 | 0.3 | 0.4 | -0.3 | 0.3 | 0.3 | 0.0 | -0.7 | 0.2 | 0.2 | -0.1 | -0.2 | -0.2 | 0.1 | 0.2 | -0.3 | -0.5 |
Extensor digitorum longus weight | 0.1 | 0.4 | 1.1 | -0.7 | 0.7 | 0.9 | 0.8 | -0.8 | 0.6 | 0.4 | -0.5 | 0.4 | -0.4 | 0.4 | -0.6 | -0.5 | 0.6 | -0.6 | 0.3 | 1.1 | -0.5 | -0.7 | 0.5 | 0.5 | -0.7 | -0.7 | -0.5 | 0.5 | 0.6 | -0.5 | -1.0 |
Soleus weight | 0.1 | 0.2 | 1.0 | 0.2 | -0.2 | -0.3 | 0.4 | -0.4 | 0.5 | 0.4 | -0.4 | 0.3 | -0.3 | 0.3 | -0.5 | -0.6 | 0.3 | -0.3 | 0.2 | 1.0 | -0.5 | 0.8 | 0.6 | 0.3 | -0.4 | -0.4 | -0.1 | 0.5 | 0.4 | -0.3 | -0.7 |
Times rat made contact with spout | 0.1 | 0.1 | 0.4 | 0.4 | -0.4 | -0.2 | -0.2 | 0.2 | -0.3 | 0.1 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.6 | -0.2 | 0.2 | -0.3 | -0.1 | 0.2 | -0.4 | -0.1 | -0.2 | 0.1 | 0.3 | 0.2 | -0.1 | -0.1 | 0.2 | 0.2 |
Mean time between licks in bursts | 0.1 | 0.2 | 1.8 | -0.1 | 0.1 | 0.4 | -0.2 | 0.2 | -0.3 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 0.3 | 1.3 | -0.3 | 0.3 | -0.2 | -0.3 | 0.4 | -1.1 | -0.2 | -0.2 | 0.2 | 0.2 | 0.1 | -0.3 | -0.2 | 0.3 | 0.4 |
Water consumed over 24 hours | 0.1 | 0.1 | 0.3 | 0.0 | -0.0 | 0.2 | -0.4 | 0.4 | -0.5 | -0.3 | 0.2 | -0.2 | 0.2 | -0.2 | 0.5 | -0.3 | -0.3 | 0.2 | -0.3 | -0.1 | 0.5 | -0.0 | -0.3 | -0.4 | 0.3 | 0.5 | 0.3 | -0.4 | -0.3 | 0.4 | -0.1 |
Indifference point 0 sec | 0.1 | 0.2 | 1.8 | 0.8 | -0.9 | -1.3 | 0.1 | -0.1 | 0.3 | 0.5 | 0.0 | 0.1 | -0.1 | 0.1 | -0.3 | 0.1 | 0.1 | -0.1 | 0.1 | 0.4 | -0.5 | 1.3 | 0.3 | 0.3 | -0.1 | -0.1 | -0.4 | 0.5 | 0.3 | -0.1 | 0.3 |
Indifference point function ln k | 0.1 | 0.2 | 1.4 | 0.3 | -0.4 | -0.5 | 0.3 | -0.3 | 0.2 | 0.3 | -0.2 | 0.5 | -0.5 | 0.5 | -0.2 | -0.3 | 0.2 | -0.2 | 0.6 | 0.8 | -0.5 | 1.2 | 0.3 | 0.3 | -0.2 | -0.2 | -0.2 | 0.5 | 0.3 | -0.2 | -0.5 |
Indifference point function log k | 0.1 | 0.2 | 1.4 | 0.3 | -0.4 | -0.5 | 0.3 | -0.3 | 0.2 | 0.3 | -0.2 | 0.5 | -0.5 | 0.5 | -0.2 | -0.3 | 0.2 | -0.2 | 0.6 | 0.8 | -0.5 | 1.2 | 0.3 | 0.3 | -0.2 | -0.2 | -0.2 | 0.5 | 0.3 | -0.2 | -0.5 |
Reaction time number correct | 0.1 | 0.2 | 0.8 | 0.3 | -0.3 | -0.6 | 0.4 | -0.4 | 0.5 | 0.6 | -0.3 | 0.3 | -0.3 | 0.3 | -0.5 | 0.3 | 0.1 | -0.2 | 0.1 | 0.3 | -0.5 | 0.3 | 0.5 | 0.5 | -0.3 | -0.4 | -0.9 | 0.4 | 0.4 | -0.1 | -0.1 |
Reaction time trials correct on left | 0.1 | 0.2 | 0.8 | 0.3 | -0.3 | -0.6 | 0.4 | -0.4 | 0.5 | 0.6 | -0.3 | 0.3 | -0.3 | 0.3 | -0.5 | 0.3 | 0.1 | -0.2 | 0.1 | 0.3 | -0.5 | 0.3 | 0.5 | 0.5 | -0.3 | -0.4 | -0.9 | 0.4 | 0.4 | -0.1 | -0.1 |
Reaction time premature initiation rate | 0.1 | 0.1 | 1.7 | -0.3 | 0.3 | 0.5 | -0.3 | 0.3 | 0.1 | -0.1 | 0.0 | 0.4 | -0.4 | 0.4 | -0.1 | -1.3 | 0.1 | -0.1 | 0.3 | 0.4 | 0.2 | 0.5 | -0.2 | -0.2 | 0.2 | 0.2 | 0.2 | -0.1 | -0.1 | -0.0 | -0.8 |
Reaction time premature initiations | 0.1 | 0.1 | 0.9 | 0.0 | -0.0 | -0.0 | -0.2 | 0.2 | 0.2 | 0.1 | 0.0 | 0.4 | -0.4 | 0.4 | -0.2 | -0.9 | -0.1 | 0.0 | 0.2 | 0.3 | 0.1 | 0.7 | -0.1 | -0.1 | 0.2 | 0.2 | -0.1 | -0.0 | -0.0 | 0.1 | -0.5 |
Cocaine response after cond. corrected | 0.1 | 0.1 | 0.4 | 0.6 | -0.6 | -0.6 | -0.4 | 0.4 | -0.3 | -0.2 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.3 | -0.4 | 0.4 | -0.3 | -0.3 | 0.3 | 0.3 | -0.1 | -0.3 | 0.5 | 0.5 | 0.4 | -0.2 | -0.3 | 0.3 | 0.6 |
Cocaine response after cond. not corrected | 0.1 | 0.2 | 0.6 | 0.6 | -0.6 | -0.5 | -0.4 | 0.4 | -0.3 | -0.3 | 0.3 | -0.3 | 0.3 | -0.3 | 0.3 | 0.5 | -0.4 | 0.4 | -0.3 | -0.5 | 0.3 | 0.3 | -0.2 | -0.4 | 0.5 | 0.4 | 0.5 | -0.3 | -0.3 | 0.4 | 0.8 |
Cocaine response before conditioning | 0.1 | 0.1 | 0.7 | -0.1 | 0.1 | 0.2 | -0.2 | 0.2 | -0.0 | -0.3 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 | 0.9 | -0.1 | 0.1 | -0.0 | -0.5 | 0.1 | -0.3 | -0.2 | -0.2 | 0.1 | 0.0 | 0.3 | -0.2 | -0.2 | 0.1 | 0.4 |
Lifetime Intake | 0.1 | 0.1 | 1.4 | 0.2 | -0.2 | -0.3 | 0.1 | -0.1 | 0.1 | 0.1 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | -1.2 | 0.0 | -0.0 | 0.2 | 0.6 | -0.2 | 1.1 | 0.1 | 0.1 | -0.1 | -0.1 | -0.1 | 0.2 | 0.1 | 0.0 | -0.5 |
Incentive Sensitization - Responses | 0.1 | 0.1 | 0.2 | -0.2 | 0.2 | 0.2 | 0.2 | -0.2 | 0.2 | 0.2 | -0.4 | 0.1 | -0.1 | 0.1 | -0.2 | -0.4 | 0.3 | -0.4 | -0.1 | 0.2 | -0.1 | -0.2 | 0.3 | 0.3 | -0.2 | -0.2 | -0.2 | 0.2 | 0.2 | -0.4 | -0.0 |
Progressive ratio test 2 breakpoint | 0.1 | 0.2 | 1.0 | 0.2 | -0.2 | -0.2 | 0.1 | -0.1 | 0.1 | 0.4 | -0.4 | 0.4 | -0.4 | 0.4 | -0.1 | -0.8 | 0.3 | -0.4 | 0.3 | 0.8 | -0.2 | 1.0 | 0.4 | 0.3 | -0.1 | -0.0 | -0.1 | 0.4 | 0.3 | -0.4 | -0.4 |
Total sessions with >9 infusions | 0.1 | 0.1 | 0.3 | -0.5 | 0.5 | 0.5 | 0.5 | -0.5 | 0.5 | 0.0 | -0.1 | -0.0 | 0.0 | -0.0 | -0.5 | -0.5 | 0.1 | -0.2 | -0.1 | 0.1 | -0.3 | -0.6 | 0.0 | 0.3 | -0.6 | -0.5 | -0.5 | 0.1 | 0.3 | -0.2 | -0.4 |
Short access day 10 total infusions | 0.1 | 0.1 | 0.5 | 0.1 | -0.1 | -0.1 | -0.2 | 0.2 | -0.2 | -0.4 | 0.3 | -0.2 | 0.2 | -0.2 | 0.2 | -0.7 | -0.3 | 0.3 | -0.3 | -0.2 | 0.3 | 0.2 | -0.3 | -0.3 | 0.2 | 0.3 | 0.1 | -0.3 | -0.3 | 0.3 | 0.0 |
Short access total locomotion | 0.1 | 0.1 | 0.9 | 0.2 | -0.2 | -0.2 | -0.0 | 0.0 | 0.1 | 0.4 | -0.1 | 0.5 | -0.5 | 0.5 | -0.1 | -0.6 | 0.1 | -0.1 | 0.4 | 0.9 | -0.2 | 0.7 | 0.3 | 0.1 | -0.0 | 0.1 | 0.0 | 0.3 | 0.2 | -0.1 | -0.7 |
Number of responses in last shaping day | 0.1 | 0.1 | 0.3 | 0.2 | -0.2 | -0.1 | -0.4 | 0.4 | -0.6 | -0.3 | 0.3 | -0.5 | 0.5 | -0.5 | 0.6 | 0.1 | -0.3 | 0.3 | -0.3 | -0.2 | 0.4 | -0.1 | -0.3 | -0.3 | 0.4 | 0.4 | 0.2 | -0.3 | -0.3 | 0.5 | 0.2 |
Locomotion velocity, session 2 | 0.1 | 0.1 | 1.1 | 0.1 | -0.1 | 0.0 | -0.1 | 0.1 | -0.1 | 0.0 | 0.0 | 0.0 | -0.0 | 0.0 | 0.1 | 1.1 | -0.1 | 0.1 | 0.0 | -0.2 | 0.1 | -0.6 | 0.1 | -0.1 | 0.1 | 0.2 | 0.3 | -0.0 | -0.1 | 0.0 | 0.5 |
Condit. Reinf. lever presses | 0.1 | 0.1 | 1.5 | -0.1 | 0.1 | -0.1 | 0.0 | -0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.1 | -1.2 | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | 0.8 | -0.3 | 0.1 | -0.1 | -0.2 | -0.2 | 0.1 | 0.1 | -0.1 | -0.3 |
Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 1.8 | 0.2 | -0.2 | -0.6 | 0.2 | -0.2 | 0.3 | 0.1 | -0.0 | 0.0 | -0.0 | 0.0 | -0.3 | -1.4 | 0.2 | -0.1 | 0.1 | 0.4 | -0.4 | 0.9 | 0.0 | 0.2 | -0.3 | -0.3 | -0.1 | 0.2 | 0.2 | -0.2 | -0.2 |
Pavlov. Cond. index score | 0.1 | 0.1 | 1.7 | 0.4 | -0.4 | -0.8 | -0.1 | 0.1 | 0.0 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -0.0 | -1.3 | -0.0 | 0.1 | 0.0 | 0.1 | -0.2 | 1.2 | -0.1 | -0.0 | -0.0 | -0.0 | 0.2 | 0.1 | -0.0 | 0.0 | 0.1 |
Pavlov. Cond. lever contacts | 0.1 | 0.2 | 1.6 | 0.4 | -0.4 | -0.8 | -0.0 | 0.0 | 0.2 | 0.1 | 0.1 | -0.0 | 0.0 | -0.0 | -0.2 | -1.1 | -0.0 | 0.0 | 0.1 | 0.2 | -0.3 | 1.3 | 0.0 | 0.1 | -0.1 | -0.1 | 0.0 | 0.2 | 0.1 | -0.0 | 0.0 |
Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.1 | 1.5 | 0.3 | -0.3 | -0.6 | -0.1 | 0.1 | -0.0 | -0.1 | 0.1 | -0.0 | 0.0 | -0.0 | 0.0 | -1.2 | -0.0 | 0.1 | 0.0 | 0.0 | -0.2 | 1.0 | -0.1 | -0.1 | -0.0 | -0.0 | 0.2 | 0.1 | -0.1 | 0.0 | 0.1 |
Bone: elastic work | 0.1 | 0.2 | 1.0 | -0.8 | 0.8 | 1.0 | 0.4 | -0.4 | 0.3 | 0.1 | -0.3 | 0.2 | -0.2 | 0.2 | -0.3 | 0.2 | 0.3 | -0.3 | 0.3 | 0.0 | -0.1 | -0.8 | 0.2 | 0.2 | -0.4 | -0.4 | -0.2 | 0.1 | 0.2 | -0.3 | -0.7 |
Bone: maximum moment | 0.1 | 0.2 | 1.0 | -0.1 | 0.1 | -0.2 | 0.4 | -0.4 | 0.4 | 0.4 | -0.4 | 0.3 | -0.3 | 0.3 | -0.4 | -0.7 | 0.4 | -0.4 | 0.3 | 0.6 | -0.6 | 1.0 | 0.5 | 0.5 | -0.4 | -0.5 | -0.6 | 0.5 | 0.5 | -0.4 | -0.7 |
Time to tail flick, vehicle, after self-admin | 0.1 | 0.1 | 0.1 | -0.1 | 0.1 | 0.0 | -0.3 | 0.3 | -0.3 | -0.4 | 0.3 | -0.2 | 0.2 | -0.2 | 0.3 | -0.3 | -0.2 | 0.2 | -0.3 | -0.0 | 0.3 | -0.2 | -0.3 | -0.2 | 0.2 | 0.2 | 0.2 | -0.3 | -0.2 | 0.2 | -0.2 |
Delay disc. indifference point, 4s delay | 0.1 | 0.1 | 0.3 | -0.4 | 0.4 | 0.5 | -0.1 | 0.1 | -0.4 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 0.4 | 0.5 | -0.1 | 0.2 | 0.1 | -0.4 | 0.2 | -0.3 | -0.4 | -0.0 | 0.1 | 0.1 | -0.2 | -0.2 | -0.1 | 0.3 | 0.0 |
Change in fecal boli incidents, locomotor task | 0.1 | 0.1 | 0.3 | 0.3 | -0.3 | -0.3 | -0.2 | 0.2 | -0.2 | -0.2 | 0.5 | -0.4 | 0.4 | -0.4 | 0.2 | 0.3 | -0.3 | 0.4 | -0.1 | -0.1 | 0.0 | 0.5 | -0.5 | -0.2 | 0.1 | 0.0 | 0.4 | -0.1 | -0.2 | 0.2 | 0.2 |
Vertical activity count, locomotor time 1 | 0.1 | 0.1 | 0.4 | 0.2 | -0.2 | -0.2 | 0.2 | -0.2 | 0.1 | 0.6 | -0.1 | 0.4 | -0.4 | 0.4 | -0.1 | 0.1 | -0.0 | -0.1 | 0.2 | 0.6 | -0.3 | 0.1 | 0.4 | 0.2 | -0.3 | -0.3 | -0.3 | 0.3 | 0.3 | -0.1 | -0.4 |
Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 1.5 | -0.1 | 0.1 | 0.1 | -0.2 | 0.2 | -0.1 | -0.2 | 0.0 | -0.2 | 0.2 | -0.2 | 0.1 | -1.2 | -0.1 | 0.0 | 0.1 | 0.4 | 0.2 | 0.1 | -0.1 | -0.1 | 0.1 | 0.2 | 0.0 | -0.1 | -0.1 | 0.0 | -0.6 |
Seeking ratio, delayed vs. immediate footshock | 0.1 | 0.1 | 0.2 | 0.3 | -0.3 | -0.3 | -0.4 | 0.4 | -0.3 | -0.4 | 0.2 | -0.3 | 0.3 | -0.3 | 0.3 | -0.4 | -0.1 | 0.2 | -0.5 | -0.4 | 0.5 | -0.2 | -0.2 | -0.3 | 0.4 | 0.5 | 0.4 | -0.3 | -0.3 | 0.2 | 0.4 |
Locomotion in novel chamber | 0.1 | 0.1 | 1.1 | -0.0 | 0.0 | 0.2 | -0.0 | 0.0 | -0.1 | -0.2 | 0.2 | -0.1 | 0.1 | -0.1 | 0.1 | -1.1 | -0.2 | 0.1 | 0.2 | 0.6 | -0.1 | 1.0 | -0.2 | -0.2 | 0.0 | 0.0 | 0.2 | 0.0 | -0.0 | 0.2 | -0.7 |
Latency to leave start box in cocaine runway, M | 0.1 | 0.1 | 0.8 | 0.4 | -0.4 | -0.9 | 0.4 | -0.4 | 0.3 | -0.0 | -0.1 | -0.2 | 0.2 | -0.2 | -0.3 | -0.4 | 0.1 | -0.0 | -0.3 | -0.2 | -0.4 | 0.7 | 0.1 | 0.2 | -0.2 | -0.4 | -0.2 | 0.1 | 0.1 | -0.2 | 0.3 |
Locomotor testing distance | 0.0 | 0.1 | 0.4 | 0.3 | -0.3 | -0.5 | -0.2 | 0.2 | -0.2 | -0.1 | 0.1 | -0.3 | 0.3 | -0.3 | 0.2 | -0.1 | -0.0 | 0.1 | -0.0 | 0.1 | 0.0 | 0.6 | -0.1 | -0.1 | 0.2 | 0.3 | 0.2 | 0.0 | -0.1 | -0.0 | -0.1 |
Reaction time mean | 0.0 | 0.1 | 1.0 | -0.2 | 0.2 | 0.2 | 0.0 | -0.0 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.1 | -1.0 | 0.0 | -0.1 | -0.0 | 0.3 | -0.0 | 0.7 | 0.1 | -0.0 | 0.0 | -0.0 | -0.0 | 0.0 | -0.0 | -0.0 | -0.4 |
Reaction time mean AUC | 0.0 | 0.0 | 0.8 | -0.1 | 0.1 | 0.2 | 0.0 | -0.0 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 | 0.1 | -0.0 | -0.9 | -0.0 | -0.1 | -0.0 | 0.3 | -0.0 | 0.6 | 0.1 | -0.0 | 0.0 | -0.0 | 0.1 | 0.0 | -0.0 | -0.0 | -0.3 |
Pavlov. Cond. magazine entry latency | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | -0.3 | 0.1 | -0.1 | 0.0 | 0.3 | 0.0 | 0.0 | -0.0 | 0.0 | -0.0 | -0.2 | 0.0 | -0.1 | 0.1 | 0.4 | -0.2 | 0.3 | 0.1 | 0.2 | -0.2 | -0.2 | -0.3 | 0.2 | 0.2 | 0.0 | -0.0 |
Incentive Sensitization - Breakpoint | 0.0 | 0.0 | 0.2 | 0.1 | -0.1 | -0.1 | -0.1 | 0.1 | -0.0 | 0.1 | -0.2 | -0.1 | 0.1 | -0.1 | 0.0 | -0.4 | 0.1 | -0.1 | -0.2 | 0.1 | 0.1 | -0.0 | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 | 0.0 | 0.0 | -0.2 | 0.1 |
Short access day 1 total infusions | 0.0 | 0.1 | 0.2 | 0.2 | -0.2 | -0.1 | -0.1 | 0.1 | -0.1 | -0.3 | 0.3 | -0.4 | 0.4 | -0.4 | 0.1 | -0.4 | -0.3 | 0.3 | -0.1 | -0.0 | 0.1 | 0.2 | -0.3 | -0.2 | 0.0 | 0.1 | 0.1 | -0.2 | -0.2 | 0.3 | -0.0 |
Short access total infusions | 0.0 | 0.0 | 0.4 | -0.2 | 0.2 | 0.2 | 0.3 | -0.3 | 0.3 | -0.0 | -0.1 | -0.1 | 0.1 | -0.1 | -0.3 | -0.6 | 0.1 | -0.1 | -0.0 | 0.2 | -0.1 | -0.1 | 0.1 | 0.2 | -0.3 | -0.2 | -0.4 | 0.1 | 0.2 | -0.1 | -0.3 |
Condit. Reinf. inactive responses | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | -0.3 | -0.1 | 0.1 | -0.2 | -0.2 | 0.1 | -0.2 | 0.2 | -0.2 | 0.2 | -0.1 | -0.1 | 0.1 | -0.2 | -0.3 | 0.0 | 0.2 | -0.1 | -0.0 | 0.1 | 0.1 | 0.0 | -0.1 | -0.1 | 0.1 | 0.3 |
Distance moved, locomotor task time 1 | 0.0 | 0.0 | 0.2 | 0.0 | -0.1 | 0.1 | 0.1 | -0.1 | 0.1 | 0.5 | -0.2 | 0.4 | -0.4 | 0.4 | -0.1 | 0.2 | 0.1 | -0.1 | 0.1 | 0.2 | -0.1 | -0.3 | 0.4 | 0.1 | -0.1 | -0.1 | -0.1 | 0.1 | 0.1 | -0.1 | -0.1 |
Fe content in liver | 0.0 | 0.0 | 0.3 | 0.3 | -0.3 | -0.4 | -0.1 | 0.1 | 0.1 | 0.2 | 0.0 | -0.0 | 0.0 | -0.0 | -0.1 | 0.2 | -0.0 | 0.0 | 0.2 | 0.6 | -0.1 | 0.5 | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 | 0.1 | 0.1 | 0.0 | -0.4 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.