Hub : Genes

Fign

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000004679	0.1	0.05	5.5e-12	0.07	0.08	0.07	0.07	1.1e-08	4.9e-09	3.3e-08	3.0e-08
2	Brain	gene expression	ENSRNOG00000004679	0.03	0.02	5.0e-03	0.02	0.02	0	0.02	4.5e-03	7.7e-03	1.0e-01	1.2e-02
3	Liver	gene expression	ENSRNOG00000004679	0.05	0.04	6.0e-06	0.03	0.04	0.04	0.04	1.4e-04	1.2e-05	1.5e-05	1.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
BMI with tail	0.9	2.8	5.5	-1.4	2.3	-1.0
BMI without tail	0.0	0.1	0.2	-0.2	0.2	-0.4
Body weight	0.2	0.7	1.8	0.4	0.4	1.4
Epididymis fat weight	11.3	26.5	27.2	-5.2	5.0	-5.2
Glucose	0.3	0.5	0.7	0.9	-0.4	0.7
Heart weight	0.1	0.2	0.4	0.1	0.6	0.4
Left kidney weight	2.0	5.7	9.1	2.5	-1.3	3.0
Right kidney weight	1.5	4.3	6.9	2.3	-0.8	2.6
Tail length	2.9	8.6	11.6	2.7	-3.4	2.6
Length with tail	1.4	5.2	7.1	2.2	-1.9	2.7
Length without tail	0.8	1.7	3.8	1.0	-0.3	2.0
Liver weight, left	0.1	0.1	0.2	0.5	-0.1	0.4
Liver weight, right	0.6	0.9	1.5	1.1	-0.1	1.2
Parametrial fat weight	3.7	7.3	9.0	-2.4	2.6	-3.0
Retroperitoneal fat weight	3.9	12.8	16.4	-3.2	4.0	-3.4
Intraocular pressure	0.8	1.1	1.5	1.0	-1.0	1.2
Extensor digitorum longus weight	0.4	1.8	2.3	1.5	-0.9	1.5
Soleus weight	0.2	0.5	0.8	0.9	-0.3	0.8
Tibialis anterior weight	0.2	0.8	1.1	-1.1	1.0	-0.6
Tibia length	7.4	20.9	25.6	4.3	-4.3	5.1
Number of licking bursts	0.1	0.1	0.1	-0.3	0.1	-0.3
Food consumed during 24 hour testing period	0.8	1.0	1.4	0.9	-0.9	1.2
Times rat made contact with spout	2.5	2.9	3.5	-1.9	1.6	-1.6
Mean time between licks in bursts	1.3	1.8	2.6	1.6	-1.1	1.3
Mean num. licks in bursts	0.4	0.5	0.7	-0.7	0.8	-0.6
Std. dev. time between licks in bursts	2.0	2.3	2.5	1.6	-1.4	1.6
Water consumed over 24 hours	0.4	0.5	1.1	0.5	-0.2	1.0
Indifference point 0 sec	0.4	0.6	1.0	-0.8	1.0	-0.4
Indifference point AUC	2.9	3.4	6.9	1.6	-2.6	0.8
Indifference point function ln k	0.6	0.9	2.0	-0.6	1.4	-0.4
Indifference point function log k	0.6	0.9	2.0	-0.6	1.4	-0.4
Delay discounting total patch changes 0 sec	0.9	1.5	2.1	-1.3	1.4	-0.9
Delay discounting total patch changes 12 sec	1.2	1.6	2.0	1.2	-1.4	1.2
Delay discounting total patch changes 18 sec	1.2	1.6	2.2	1.2	-1.5	1.1
Delay discounting total patch changes 24 sec	1.3	1.6	2.1	1.0	-1.5	1.4
Delay discounting total patch changes 6 sec	0.2	0.3	0.5	-0.6	0.4	-0.7
Delay discounting time to switch 0 sec	1.0	1.5	3.1	-1.0	1.8	-0.4
Delay discounting water rate 0 sec	2.2	3.5	4.0	1.7	-2.0	1.9
Delay discounting water rate 12 sec	1.6	2.4	2.9	1.7	-1.3	1.6
Delay discounting water rate 18 sec	3.0	4.0	4.4	1.9	-2.1	2.0
Delay discounting water rate 24 sec	0.9	1.3	1.9	1.0	-1.4	0.9
Delay discounting water rate 6 sec	1.9	2.7	2.8	1.7	-1.6	1.7
Locomotor activity	3.3	5.2	5.6	2.1	-2.3	2.4
Locomotor testing distance	5.6	9.3	10.3	3.2	-2.7	3.2
Locomotor testing rearing	7.4	11.6	13.8	3.7	-3.0	3.5
Light reinforcement 1	0.1	0.1	0.3	0.3	-0.5	0.1
Light reinforcement 2	0.2	0.3	0.4	-0.1	-0.7	-0.6
Reaction time number correct	0.2	0.2	0.3	0.5	0.5	0.4
Reaction time mean minus median	0.8	1.0	1.8	-1.1	0.2	-1.3
Reaction time mean minus median AUC	1.8	2.3	4.0	-1.6	0.7	-2.0
Reaction time num false alarms	5.1	7.0	8.3	2.9	-2.6	2.4
Reaction time num false alarms AUC	5.3	7.4	8.5	2.9	-2.6	2.6
Reaction time trials correct on left	0.2	0.2	0.3	0.5	0.5	0.4
Reaction time trials on left	0.2	0.2	0.3	0.6	0.5	0.5
Reaction time mean	1.5	2.1	4.1	-1.5	0.2	-2.0
Reaction time mean AUC	2.5	3.3	5.7	-1.9	0.7	-2.4
Median of all reaction times	1.4	1.9	3.7	-1.4	0.2	-1.9
Reaction time omissions	0.5	0.7	1.2	-0.8	0.6	-1.1
Reaction time false alarm rate	3.8	5.4	6.8	2.3	-2.6	2.0
Reaction time premature initiation rate	0.0	0.1	0.2	-0.1	-0.4	0.0
Reaction time premature initiations	0.0	0.0	0.1	0.2	-0.1	0.2
Std. dev. reaction times	0.6	0.8	1.6	-0.8	-0.2	-1.3
Reaction time trials completed	0.2	0.2	0.3	0.6	0.5	0.5
Reaction time trials AUC	0.3	0.4	0.6	0.8	0.2	0.7
Social response proportion	1.6	1.7	2.4	-1.4	1.0	-1.5
Social responses	3.5	4.5	5.0	2.1	-2.2	2.1
Social time	0.2	0.2	0.6	-0.0	-0.8	-0.1
Conditioned locomotion	0.0	0.0	0.1	-0.1	-0.2	-0.0
Cocaine response after cond. corrected	4.7	5.2	7.1	-2.1	2.7	-2.0
Cocaine response after cond. not corrected	1.0	1.1	2.0	-1.0	1.4	-0.7
Cocaine response before conditioning	5.7	6.9	7.8	2.3	-2.8	2.8
Saline control response	0.5	0.7	0.9	-0.9	0.9	-0.7
Condit. Reinf. active minus inactive responses	6.0	7.4	7.9	2.6	-2.7	2.8
Condit. Reinf. active-inactive response ratio	3.7	3.9	4.6	1.9	-2.1	1.8
Condit. Reinf. active responses	4.8	6.6	8.5	2.5	-2.3	2.9
Condit. Reinf. inactive responses	0.2	0.3	0.8	0.4	0.0	0.9
Condit. Reinf. lever presses	5.5	7.6	8.6	2.6	-2.7	2.9
Condit. Reinf. lever reinforcers received	4.0	5.7	6.5	2.4	-2.2	2.6
Pavlov. Cond. lever latency	4.6	6.2	7.9	-2.3	2.4	-2.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.5	0.0	0.4
Pavlov. Cond. change in total contacts	2.8	3.8	4.9	1.7	-2.2	1.9
Pavlov. Cond. index score	1.1	1.4	2.4	0.8	-1.1	1.6
Pavlov. Cond. latency score	0.8	1.0	1.7	0.6	-1.0	1.3
Pavlov. Cond. lever contacts	3.5	4.9	6.5	1.9	-2.1	2.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.3	0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.1	1.4	-0.8	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.9	0.7	-1.0	1.4
Pavlov. Cond. response bias	2.3	3.1	4.7	1.4	-1.6	2.2
Conditioned reinforcement - actives	0.8	0.8	1.0	0.7	-1.0	1.0
Conditioned reinforcement - inactives	0.3	0.3	0.4	0.6	-0.5	0.6
Conditioned locomotion	0.1	0.1	0.4	0.0	-0.2	0.6
Intermittent access intake day 1-15 change	5.3	5.3	6.8	2.6	-1.9	2.3
Intermittent access intake escalation	4.6	4.5	5.9	2.4	-1.8	2.2
Intermittent access intake escalation 2	1.9	1.8	2.8	1.7	-1.1	1.2
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.9	-0.1	0.9	0.0
Intermitt. access day 15 inactive lever presses	0.4	0.4	0.5	0.7	-0.5	0.7
Intermitt. access escalation Index	0.2	0.2	0.3	-0.4	0.5	-0.4
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.4	0.2	0.0
Intermittent access day 15 total infusions	1.8	2.1	2.7	1.3	-1.3	1.6
Intermittent access terminal intake (last 3 days)	1.8	2.0	2.3	1.3	-1.4	1.5
Intermittent access total infusions	0.7	0.8	1.2	0.7	-0.9	1.1
Intermittent access day 1 locomotion	0.5	0.5	0.8	-0.8	0.9	-0.3
Intermittent access day 15 total locomotion	2.0	2.1	2.8	1.6	-1.0	1.7
Intermittent access total locomotion	0.2	0.2	0.5	0.4	0.1	0.7
Intermittent access standard deviation	3.7	4.0	4.8	2.2	-1.6	2.1
Cocaine induced anxiety	3.7	4.2	5.1	-2.3	1.8	-2.0
Post-drug Anxiety	0.6	0.6	0.9	-1.0	0.8	-0.6
Baseline Anxiety	1.4	1.5	2.2	1.5	-0.5	1.4
Lifetime Intake	0.8	0.9	1.4	0.6	-0.9	1.2
Incentive Sensitization - Responses	2.3	2.3	3.2	1.4	-1.8	1.4
Incentive Sensitization - Breakpoint	2.4	2.4	3.2	1.5	-1.8	1.4
Progressive ratio test 1 active lever presses	0.4	0.4	1.1	0.1	-0.5	1.0
Progressive ratio test 1 breakpoint	0.7	0.7	1.6	0.4	-0.7	1.3
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	0.1	0.1	0.7
Progressive ratio test 2 active lever presses	1.8	1.9	2.8	1.1	-1.7	1.3
Progressive ratio test 2 breakpoint	2.2	2.4	3.0	1.4	-1.7	1.6
Progressive ratio test 2 inactive lever presses	1.2	1.4	2.3	0.9	-1.5	1.1
Total sessions with >9 infusions	0.3	0.4	1.0	-0.1	-0.4	1.0
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.1	-0.3	0.4
Short access day 10 total inactive lever presses	0.1	0.1	0.3	0.5	0.2	0.2
Short access day 1 total infusions	0.7	0.7	1.1	0.2	-1.0	1.0
Short access day 10 total infusions	1.1	1.3	2.7	0.8	-0.6	1.7
Short access total infusions	0.4	0.5	1.0	0.2	-0.6	1.0
Short access day 1 locomotion	0.4	0.4	1.0	0.3	-0.3	1.0
Short access day 10 total locomotion	1.1	1.2	1.5	-1.2	1.2	-0.8
Short access total locomotion	0.3	0.3	0.5	-0.7	0.7	0.1
Compulsive drug intake	3.2	3.1	4.0	-1.6	2.0	-1.6
One hour access (0.3 mA shock)	1.2	1.5	1.8	1.0	-1.3	1.2
One hour access (shock baseline)	2.1	2.4	3.4	1.2	-1.8	1.5
Number of responses in last shaping day	0.4	0.4	1.1	-0.2	-1.0	0.4
Context. condit. distance diff. score	0.1	0.2	0.2	0.3	-0.5	0.5
Locomotion velocity, session 1	0.2	0.2	0.4	0.4	-0.6	0.1
Locomotion distance, session 1	0.1	0.2	0.5	0.1	-0.7	0.0
Locomotion velocity, session 2	0.7	0.8	1.6	-0.9	0.3	-1.2
Locomotion distance, session 2	0.9	1.2	1.8	0.9	-1.3	1.1
Locomotion velocity, session 3	0.4	0.5	0.8	-0.6	0.5	-0.9
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.2	-0.1
Stereotopy head waving bouts, day 3	0.5	0.6	1.4	0.5	-0.5	1.2
Stereotopy head waving duration, day 3	0.6	0.8	1.2	0.6	-0.9	1.1
Locomotion velocity, session 7	0.1	0.2	0.3	0.6	-0.3	0.2
Locomotion distance, session 7	0.2	0.3	0.5	0.7	-0.4	0.6
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.0	-0.7	0.4
Stereotopy head waving duration, day 7	0.3	0.3	0.6	0.3	-0.8	0.6
Locomotion velocity, session 8	0.2	0.2	0.4	0.3	-0.6	0.2
Locomotion distance, session 8	0.1	0.1	0.3	0.1	-0.5	0.4
Degree of sensitization distance	0.0	0.0	0.1	-0.1	0.3	0.3
Degree of sensitization stereotypy	0.5	0.6	1.1	-1.0	0.4	-0.7
Condit. Reinf. active minus inactive responses	2.3	2.6	3.3	1.5	-1.5	1.8
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	0.6	-0.3	0.8
Condit. Reinf. active responses	4.4	5.3	5.6	2.4	-2.3	2.3
Condit. Reinf. inactive responses	3.8	4.5	5.7	2.4	-2.0	1.9
Incentive salience index mean	2.7	3.3	3.7	1.7	-1.8	1.9
Condit. Reinf. lever presses	0.5	0.6	0.7	0.8	-0.7	0.9
Time in familiar zone, hab. session 1	1.1	1.1	1.9	0.9	-1.4	0.7
Time in novel zone, hab. session 1	2.0	2.0	3.1	-1.2	1.8	-1.2
Total zone transitions, hab. session 1	2.2	3.1	3.7	1.5	-1.9	1.8
Total locomotion distance, hab. session 1	3.3	4.7	5.5	2.2	-2.3	2.0
Locomotion velocity, hab. session 1	2.7	3.9	4.4	2.0	-2.1	1.8
Time in familiar zone, hab. session 2	1.1	1.1	1.4	-1.2	0.8	-1.1
Time in novel zone, hab. session 2	0.5	0.5	0.7	0.7	-0.4	0.9
Total zone transitions, hab. session 2	1.3	1.7	2.2	0.9	-1.5	1.5
Total locomotion distance, hab. session 2	0.3	0.4	0.6	0.4	-0.8	0.6
Locomotion velocity, hab. session 2	0.3	0.5	0.7	0.5	-0.9	0.6
Novel to familiar place preference ratio	0.9	1.0	1.6	-1.1	1.3	-0.4
Novelty place preference	1.2	1.3	2.0	-1.3	1.4	-0.5
Time in novel zone, NPP test	1.2	1.3	2.0	-1.2	1.4	-0.5
Total zone transitions, NPP test	0.4	0.6	1.2	0.3	-1.1	0.7
Total locomotion distance, NPP test	1.2	1.7	2.8	1.0	-1.7	1.1
Locomotion velocity, NPP test	1.3	1.8	2.8	1.1	-1.7	1.2
Pavlov. Cond. lever latency	0.2	0.3	0.6	-0.1	0.5	-0.7
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.1	0.3	0.2
Pavlov. Cond. change in total contacts	0.6	0.7	0.8	0.6	-0.9	0.9
Pavlov. Cond. index score	0.4	0.5	0.8	0.5	-0.6	0.9
Pavlov. Cond. latency score	0.4	0.5	0.9	0.4	-0.6	1.0
Pavlov. Cond. lever contacts	0.5	0.5	1.0	0.4	-0.7	1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	0.4	-0.3
Pavlov. Cond. intertrial magazine entries	2.9	3.5	3.9	2.0	-1.7	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	0.5	-0.5	0.9
Pavlov. Cond. response bias	0.1	0.1	0.2	0.2	-0.2	0.4
Bone: apparent density	0.1	0.2	0.4	0.1	-0.6	0.3
Bone surface	1.2	2.0	3.0	1.2	-1.7	1.3
Bone volume	0.4	0.7	1.0	0.6	-1.0	0.9
Bone: connectivity density	0.2	0.3	0.8	0.1	-0.9	0.2
Bone: cortical apparent density	0.0	0.0	0.1	0.2	-0.3	0.1
Bone: cortical area	3.5	5.3	7.2	2.2	-2.0	2.7
Bone: cortical porosity	1.4	1.5	2.1	1.1	-1.0	1.4
Bone: cortical porosity	3.0	3.2	4.0	1.8	-1.6	2.0
Bone: cortical thickness	0.8	1.4	2.5	0.9	-0.9	1.6
Bone: cortical thickness	2.3	2.7	4.2	1.4	-1.4	2.1
Bone: cortical tissue density	0.0	0.0	0.0	0.0	-0.2	-0.1
Bone: elastic displacement	1.9	2.1	2.7	-1.4	1.7	-1.3
Bone: elastic work	0.5	0.6	1.1	-0.7	1.0	-0.6
Bone: endosteal estimation	1.8	3.8	4.3	2.0	-2.1	1.7
Bone: endosteal perimeter	3.7	7.5	9.0	3.0	-2.7	2.5
Bone: final force	3.3	5.5	5.7	2.4	-2.4	2.3
Bone: final moment	2.8	4.7	5.1	2.3	-2.1	2.1
Bone: marrow area	1.8	3.9	4.4	2.0	-2.1	1.8
Bone: maximum diameter	2.9	5.4	6.5	2.2	-2.2	2.6
Bone: maximum force	3.6	6.2	6.9	2.6	-2.3	2.5
Bone: maximum moment	3.3	5.7	6.6	2.6	-2.1	2.4
Bone: minimum diameter	1.7	3.2	3.7	1.9	-1.6	1.9
Bone: periosteal estimation	3.3	6.8	7.5	2.6	-2.4	2.7
Bone: periosteal perimeter	5.4	9.0	9.9	3.1	-2.7	3.1
Bone: post-yield work	1.6	2.1	2.8	1.7	-1.2	1.4
Bone: stiffness	5.5	8.7	9.2	3.0	-2.8	3.0
Bone: tissue strength	0.7	0.7	0.9	1.0	-0.8	0.7
Bone: trabecular number	0.1	0.1	0.3	-0.5	-0.2	-0.4
Bone: trabecular spacing	0.1	0.2	0.5	-0.2	0.7	0.0
Bone: trabecular thickness	0.8	1.0	1.1	1.0	-1.1	0.8
Bone: trabecular tissue density	2.4	3.3	3.3	1.8	-1.8	1.8
Breakpoint value in progressive ratio session	1.5	1.6	2.0	-1.4	1.0	-1.4
Distance traveled before self-admin	5.2	5.5	8.2	2.2	-1.9	2.9
Distance traveled after self-admin	4.0	4.5	5.7	2.4	-1.7	2.2
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	-0.7	0.8	-0.4
Delta time in open arm before/after self-admin	0.3	0.3	0.6	0.8	-0.3	0.5
Diff in mean of infusions in LGA sessions	12.6	14.1	16.7	-4.1	3.4	-3.8
Extinction: sum of active levers before priming	0.6	0.6	0.9	0.9	-0.4	0.9
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.2	0.7	0.4
Delta distance traveled before/after self-admin	0.4	0.4	0.8	-0.2	0.5	-0.9
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	0.7	-0.5	0.2
Time in closed arm before self-admin	0.1	0.1	0.2	-0.2	0.3	-0.5
Time in closed arm after self-admin	0.1	0.1	0.1	0.4	-0.2	0.4
Time in open arm before self-admin	0.6	0.6	1.2	-1.1	-0.3	-0.7
Time in open arm after self-admin	0.0	0.0	0.1	-0.4	0.1	-0.1
Sum of active levers in priming session hrs 5-6	2.5	2.4	3.6	-1.4	1.9	-1.4
Time to tail flick, vehicle, before self-admin	2.3	2.3	2.8	-1.5	1.7	-1.4
Time to tail flick, vehicle, after self-admin	4.8	5.2	6.6	-1.9	2.3	-2.6
Time to tail flick, test, before self-admin	1.6	1.6	2.2	-1.1	1.1	-1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.3	0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.2	-0.2	-0.5
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	0.1	-0.6	0.3
Ambulatory time before self-admin	7.3	7.7	10.4	2.6	-2.4	3.2
Ambulatory time after self-admin	3.8	4.2	5.2	2.3	-1.8	2.1
Total heroin consumption	1.6	1.9	3.0	-1.3	1.7	-1.0
Area under the delay curve	0.2	0.2	0.3	-0.6	0.2	-0.4
Delay disc. indifference point, 0s delay	0.3	0.3	0.7	0.8	-0.1	0.6
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	-0.7	0.4	-0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.6	-0.1	-0.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.3	-0.6	-0.2
Delay disc. indifference point, 4s delay	0.5	0.5	0.8	-0.7	0.6	-0.9
Delay disc. indifference point, 8s delay	0.4	0.4	0.8	-0.9	0.4	-0.5
Delay discount exponential model param	0.3	0.3	0.5	0.7	-0.3	0.6
Delay discount hyperbolic model param	0.2	0.2	0.3	0.5	-0.2	0.5
Fecal boli incidents, locomotor time 1	0.5	0.6	1.0	-0.7	0.4	-1.0
Change in fecal boli incidents, locomotor task	1.6	1.5	2.0	1.0	-1.2	1.4
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	0.3	-0.4	0.6
Bouts of movement, locomotor time 1	8.2	9.1	11.4	-3.4	2.6	-3.0
Total resting periods, locomotor time 1	8.0	8.9	11.2	-3.3	2.5	-3.0
Rest time, locomotor task time 1	3.8	4.1	4.8	-2.1	1.7	-2.2
Distance moved, locomotor task time 1	4.0	4.4	5.8	2.4	-1.4	2.3
Vertical activity count, locomotor time 1	0.5	0.5	0.9	1.0	-0.3	0.7
Time >=10cm from walls, locomotor time 2	1.8	1.9	2.4	1.5	-0.9	1.5
Bouts of movement, locomotor time 2	8.4	9.0	9.6	-3.0	3.1	-2.9
Total resting periods, locomotor time 2	10.5	11.2	11.8	-3.4	3.3	-3.3
Rest time, locomotor task time 2	2.6	3.0	3.5	-1.9	1.5	-1.8
Distance moved, locomotor task time 2	3.0	3.4	4.6	2.1	-1.1	2.1
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.6	0.3	-0.0
Weight adjusted by age	0.6	0.7	1.6	-0.6	0.4	-1.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.6	0.5	-0.4	0.8
Locomotion in novel chamber	0.4	0.5	0.9	-1.0	0.7	-0.4
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	-0.4	0.1	0.1
Progressive ratio	0.1	0.2	0.2	-0.3	0.4	0.5
Food seeking constrained by brief footshock	0.5	0.6	0.8	-0.9	0.6	-0.9
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.0	0.1	-0.5
Run reversals in cocaine runway, females	0.2	0.2	0.5	-0.0	0.7	-0.1
Run reversals in cocaine runway, males	0.8	0.8	1.2	-0.9	0.5	-1.1
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.2	-0.2	-0.2
Latency to leave start box in cocaine runway, F	0.5	0.6	0.8	0.5	-0.9	0.8
Latency to leave start box in cocaine runway, M	1.6	1.6	2.1	-1.3	1.0	-1.4
Cd content in liver	1.0	1.1	1.4	-0.9	1.1	-1.2
Co content in liver	0.8	0.9	1.5	0.8	-0.8	1.2
Cu content in liver	0.4	0.5	0.9	0.6	-1.0	0.4
Fe content in liver	2.4	2.9	3.4	-1.7	1.6	-1.8
K content in liver	2.9	2.9	3.3	1.8	-1.8	1.5
Mg content in liver	2.6	2.7	3.2	1.8	-1.6	1.5
Mn content in liver	7.1	8.2	9.2	2.9	-3.0	2.6
Na content in liver	5.3	5.7	6.0	2.3	-2.3	2.5
Rb content in liver	1.4	1.8	2.1	1.2	-1.4	1.4
Se content in liver	0.7	0.8	0.9	-0.9	0.9	-0.9
Sr content in liver	1.1	1.0	1.4	0.9	-0.8	1.2
Zn content in liver	0.2	0.2	0.5	-0.7	0.2	-0.2