Hub : Genes

Ddx56

Models

#	tissue	modality	RNA phenotype	h²	h² se	h² P	eQTL R²	BLUP R²	ENET R²	LASSO R²	eQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000004670	0.6300	0.1200	0.0e+00	0.316	0.395	0.389	0.398	1.1e-35	1.3e-46	9.2e-46	4.3e-47
2	Adipose	mRNA stability	ENSRNOG00000004670	0.1530	0.0790	9.9e-12	0.077	0.076	0.077	0.081	5.9e-09	7.5e-09	6.3e-09	2.6e-09
3	BLA	gene expression	ENSRNOG00000004670	0.8745	0.0474	0.0e+00	0.430	0.678	0.682	0.690	5.5e-25	2.0e-48	6.4e-49	7.5e-50
4	BLA	mRNA stability	ENSRNOG00000004670	0.0820	0.0580	8.7e-04	0.018	0.049	0.021	0.027	3.6e-02	1.3e-03	2.5e-02	1.3e-02
5	Brain	gene expression	ENSRNOG00000004670	0.8500	0.0410	0.0e+00	0.460	0.721	0.721	0.723	3.6e-47	1.1e-95	1.0e-95	3.4e-96
6	Brain	mRNA stability	ENSRNOG00000004670	0.2262	0.1040	7.2e-16	0.141	0.166	0.152	0.173	5.4e-13	3.3e-15	5.5e-14	8.2e-16
7	Eye	gene expression	ENSRNOG00000004670	0.8000	0.1000	8.0e-06	0.203	0.229	0.241	0.228	4.8e-04	2.0e-04	1.3e-04	2.1e-04
8	IL	gene expression	ENSRNOG00000004670	0.9240	0.0420	0.0e+00	0.277	0.524	0.510	0.545	2.3e-07	9.6e-15	2.9e-14	1.5e-15
9	LHb	gene expression	ENSRNOG00000004670	0.8618	0.0560	0.0e+00	0.477	0.611	0.614	0.614	6.1e-13	4.6e-18	3.3e-18	3.3e-18
10	Liver	gene expression	ENSRNOG00000004670	0.5000	0.1200	0.0e+00	0.207	0.332	0.333	0.338	1.4e-22	8.2e-38	5.2e-38	1.3e-38
11	NAcc	gene expression	ENSRNOG00000004670	0.8600	0.0520	0.0e+00	0.468	0.712	0.712	0.709	1.1e-38	2.2e-74	2.1e-74	8.4e-74
12	NAcc	mRNA stability	ENSRNOG00000004670	0.0871	0.0553	5.7e-04	0.035	0.047	0.049	0.040	1.2e-03	2.1e-04	1.5e-04	5.6e-04
13	OFC	gene expression	ENSRNOG00000004670	0.9479	0.0251	0.0e+00	0.323	0.565	0.548	0.548	1.8e-08	3.6e-16	1.7e-15	1.7e-15
14	OFC	mRNA stability	ENSRNOG00000004670	0.3352	0.1519	4.5e-04	0.034	0.136	0.074	0.067	5.6e-02	4.1e-04	8.1e-03	1.1e-02
15	PL	gene expression	ENSRNOG00000004670	0.9005	0.0439	0.0e+00	0.490	0.792	0.782	0.785	5.3e-42	2.2e-95	2.1e-92	2.6e-93

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method.

Trait associations

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
Glucose	21.4	32.8	43.4	-6.1	-5.2	-5.5	-3.9	-6.0	-6.3	-4.5	-5.9	-5.9	-5.6	-5.8	-6.0	-6.0	-6.6	-6.0
Liver weight, right	7.6	12.6	15.8	3.8	2.9	3.4	2.6	3.9	3.5	3.2	3.9	3.2	3.4	3.8	3.8	3.9	3.6	4.0
Delta time in closed arm before/after self-admin	7.1	6.9	9.9	3.0	1.3	2.9	2.8	2.7	2.8	1.9	2.9	1.8	2.8	3.1	3.0	2.6	2.4	2.7
Delta time in open arm before/after self-admin	6.5	6.2	9.0	-2.7	-0.6	-2.9	-2.8	-2.5	-2.2	-1.6	-2.8	-2.1	-2.8	-3.0	-2.8	-2.4	-2.6	-2.5
Delay discounting total patch changes 18 sec	4.9	6.4	8.6	-2.8	-2.7	-2.2	-1.8	-2.9	-2.9	-2.6	-2.6	-2.0	-2.2	-2.8	-2.6	-2.7	-2.1	-2.7
Delay discounting total patch changes 0 sec	4.1	6.7	8.7	-2.8	-2.2	-2.5	-2.1	-2.9	-2.9	-2.5	-2.8	-2.1	-2.5	-2.9	-2.9	-2.8	-2.1	-2.8
Delay discounting total patch changes 6 sec	4.1	6.2	7.9	-2.7	-2.2	-2.4	-2.0	-2.7	-2.7	-2.2	-2.6	-2.2	-2.4	-2.8	-2.7	-2.6	-2.3	-2.6
Locomotion in novel chamber	3.9	4.8	9.2	2.3	0.9	2.6	2.3	2.1	2.6	0.7	2.3	2.0	2.6	2.2	2.3	1.8	3.0	2.1
Short access total locomotion	3.7	3.8	5.5	1.9	0.3	2.2	2.2	2.2	1.7	1.8	2.3	1.3	2.1	2.3	2.3	2.0	1.5	2.0
Indifference point 0 sec	3.6	5.8	7.4	-2.5	-1.9	-2.3	-2.0	-2.7	-2.6	-2.2	-2.6	-1.9	-2.4	-2.7	-2.7	-2.6	-1.9	-2.6
Delay discounting total patch changes 12 sec	3.2	4.3	5.6	-2.1	-2.0	-1.7	-1.4	-2.3	-2.4	-2.3	-2.0	-1.9	-1.9	-2.4	-2.1	-2.2	-1.8	-2.1
Times rat made contact with spout	2.9	3.3	8.0	-1.5	-2.1	-0.7	0.4	-2.1	-1.1	-2.8	-1.5	-2.7	-0.8	-1.6	-1.8	-2.2	-1.9	-2.0
Liver weight, left	2.8	4.5	5.8	2.4	1.9	2.2	1.9	2.3	2.4	1.5	2.3	1.6	2.1	2.3	2.3	2.2	2.0	2.3
Short access day 10 total locomotion	2.8	3.0	8.2	1.3	-0.2	1.4	1.3	2.1	0.7	2.9	2.0	1.2	1.4	2.2	2.1	2.2	1.0	2.1
Delay discounting water rate 0 sec	2.7	4.3	5.4	-2.2	-1.6	-2.2	-1.8	-2.2	-2.2	-1.5	-2.2	-1.9	-2.1	-2.2	-2.3	-2.2	-2.3	-2.2
Reaction time premature initiation rate	2.6	3.4	4.6	2.1	1.5	2.1	1.9	2.0	2.2	1.0	2.0	1.3	2.1	1.9	2.0	1.8	1.6	1.8
Locomotion distance, session 8	2.6	3.9	9.8	2.0	-0.3	2.7	3.1	1.6	2.2	-0.0	2.2	0.7	2.8	1.9	2.1	1.5	1.7	1.8
Locomotion in novel chamber post-restriction	2.6	3.1	4.5	1.7	0.4	2.1	1.9	1.7	1.8	0.9	1.9	1.5	2.1	1.9	2.0	1.7	1.9	1.8
Food consumed during 24 hour testing period	2.5	3.0	4.4	-1.8	-1.0	-1.8	-1.3	-1.8	-1.7	-1.3	-1.9	-1.8	-1.8	-1.6	-2.0	-1.9	-2.1	-1.9
Intermittent access intake day 1-15 change	2.5	2.5	6.7	-1.7	-2.6	-1.0	-0.7	-1.7	-1.4	-2.0	-1.5	-1.5	-1.1	-1.8	-1.5	-1.5	-1.3	-1.5
Bone: maximum diameter	2.5	4.7	7.7	-2.4	-0.8	-2.8	-2.8	-2.0	-2.6	-0.6	-2.4	-1.3	-2.6	-2.2	-2.3	-1.9	-2.2	-2.1
Short access day 1 locomotion	2.4	2.6	3.5	1.5	1.0	1.6	1.3	1.9	1.6	1.7	1.8	1.4	1.5	1.8	1.9	1.7	1.5	1.7
Locomotion distance, session 1	2.4	3.1	4.3	1.7	2.0	1.3	0.6	2.0	1.9	2.0	1.6	2.1	1.3	1.7	1.7	1.9	1.8	1.9
Intermittent access day 1 locomotion	2.3	2.3	4.4	1.4	0.2	1.4	1.3	1.7	0.8	2.1	1.8	1.0	1.4	1.9	1.8	1.8	1.0	1.8
Time in open arm before self-admin	2.3	2.5	4.1	1.6	0.2	1.7	1.6	1.6	1.5	0.9	1.7	1.5	2.0	1.9	1.6	1.5	1.8	1.5
Na content in liver	2.3	2.4	4.1	-1.8	-0.6	-1.9	-2.0	-1.5	-1.7	-0.7	-1.8	-0.7	-1.9	-1.7	-1.7	-1.5	-1.3	-1.6
Water consumed over 24 hours	2.2	2.6	3.4	-1.6	-1.2	-1.5	-1.0	-1.8	-1.6	-1.5	-1.7	-1.7	-1.5	-1.5	-1.9	-1.8	-1.8	-1.8
Social responses	2.2	2.9	4.6	-1.9	-1.2	-1.7	-1.7	-1.6	-2.1	-0.6	-1.7	-1.6	-2.1	-1.7	-1.6	-1.5	-2.1	-1.6
Conditioned locomotion	2.2	2.6	3.7	1.5	1.9	1.3	0.6	1.8	1.6	1.7	1.6	1.9	1.3	1.5	1.7	1.8	1.8	1.7
Locomotor testing rearing	2.1	3.3	4.4	-2.0	-1.1	-1.8	-1.7	-1.9	-2.1	-1.4	-2.0	-1.4	-2.0	-2.1	-1.9	-1.9	-1.8	-1.9
Time in novel zone, hab. session 2	2.1	2.1	2.7	-1.5	-0.6	-1.7	-1.4	-1.5	-1.5	-0.9	-1.6	-1.3	-1.6	-1.5	-1.6	-1.5	-1.6	-1.6
Cocaine induced anxiety	2.0	2.3	3.8	-1.5	-0.4	-1.9	-1.7	-1.3	-1.2	-0.5	-1.7	-1.4	-1.8	-1.7	-1.7	-1.3	-1.9	-1.4
Condit. Reinf. active minus inactive responses	2.0	2.2	2.8	-1.7	-1.1	-1.5	-1.2	-1.5	-1.6	-1.0	-1.6	-1.4	-1.6	-1.5	-1.6	-1.5	-1.7	-1.5
Intermittent access intake escalation	1.9	1.9	5.0	-1.4	-2.2	-0.8	-0.5	-1.4	-1.1	-1.9	-1.2	-1.4	-0.9	-1.6	-1.3	-1.4	-1.1	-1.3
Intermittent access intake escalation 2	1.9	1.9	5.0	-1.2	-1.9	-0.8	-0.3	-1.5	-0.8	-2.2	-1.4	-1.5	-0.6	-1.6	-1.5	-1.5	-1.2	-1.5
Condit. Reinf. active-inactive response ratio	1.9	2.1	3.8	-1.4	-1.6	-0.8	-0.1	-1.6	-1.1	-2.0	-1.4	-1.9	-0.9	-1.4	-1.4	-1.8	-1.6	-1.6
Time >=10cm from walls, locomotor time 2	1.9	2.0	2.8	1.3	1.1	1.4	1.0	1.6	1.5	1.4	1.5	1.5	1.3	1.6	1.7	1.5	1.3	1.5
Extensor digitorum longus weight	1.8	7.1	11.9	-2.9	-0.3	-3.4	-3.4	-2.4	-2.9	-0.6	-2.9	-1.9	-3.5	-2.7	-2.9	-2.3	-2.9	-2.5
Intermitt. access escalation Index	1.8	1.6	3.0	-1.3	-1.4	-0.9	-0.5	-1.4	-0.9	-1.7	-1.3	-1.4	-0.9	-1.5	-1.3	-1.4	-1.2	-1.3
Delay discounting water rate 18 sec	1.7	2.2	5.1	1.5	2.3	0.7	-0.0	1.8	1.4	2.1	1.3	1.8	0.6	1.5	1.4	1.7	1.4	1.6
Intermitt. access day 1 inactive lever presses	1.7	1.8	3.4	1.1	1.0	1.1	0.7	1.6	1.1	1.9	1.5	1.5	1.1	1.7	1.5	1.5	1.2	1.4
Change in fecal boli incidents, locomotor task	1.7	1.6	4.6	-1.4	-2.1	-0.6	-0.2	-1.3	-1.4	-1.5	-1.0	-1.5	-0.6	-1.2	-1.1	-1.3	-1.3	-1.2
Bouts of movement, locomotor time 1	1.7	1.8	3.2	-1.5	-1.8	-1.0	-0.8	-1.5	-1.4	-1.8	-1.4	-0.9	-0.9	-1.3	-1.4	-1.6	-0.9	-1.6
Right kidney weight	1.6	4.6	7.8	2.2	1.8	1.9	1.2	2.2	2.1	1.8	2.1	2.5	2.0	2.2	2.1	2.2	2.8	2.3
Light reinforcement 2	1.6	2.2	5.0	1.5	2.1	0.5	-0.2	1.6	1.2	2.2	1.2	2.1	0.7	1.2	1.2	1.7	1.6	1.5
Delay discounting total patch changes 24 sec	1.5	1.9	8.0	-1.0	-2.8	-0.1	0.5	-1.6	-1.3	-2.4	-0.8	-1.4	-0.1	-1.3	-0.9	-1.5	-0.7	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.8	2.4	1.5	0.8	1.5	1.3	1.4	1.4	0.9	1.5	1.1	1.5	1.3	1.5	1.4	1.3	1.4
Locomotor activity	1.4	2.2	3.0	-1.4	-1.5	-1.0	-0.7	-1.6	-1.5	-1.7	-1.5	-1.4	-1.4	-1.6	-1.4	-1.7	-1.5	-1.7
Intermitt. access day 15 inactive lever presses	1.4	1.5	2.2	-1.1	-0.8	-1.3	-1.2	-1.3	-1.5	-0.8	-1.3	-1.2	-1.3	-1.3	-1.3	-1.2	-1.4	-1.2
Incentive salience index mean	1.4	1.6	2.8	-1.4	-0.6	-1.6	-1.7	-1.2	-1.6	-0.3	-1.4	-0.7	-1.6	-1.4	-1.4	-1.1	-1.3	-1.2
Time to tail flick, vehicle, before self-admin	1.4	1.4	4.6	1.1	0.9	0.5	0.2	1.5	0.7	2.1	1.0	1.3	0.5	1.5	1.1	1.4	1.0	1.3
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	4.0	1.2	0.8	1.0	0.6	1.6	0.8	2.0	1.5	1.0	0.9	1.3	1.5	1.6	0.7	1.5
Rb content in liver	1.4	1.8	3.4	-1.4	-0.2	-1.7	-1.6	-1.2	-1.5	-0.1	-1.4	-1.4	-1.8	-1.1	-1.4	-1.0	-1.8	-1.1
Number of licking bursts	1.3	1.6	4.2	-1.3	0.3	-1.7	-2.0	-1.1	-1.1	-0.3	-1.4	0.1	-1.6	-1.6	-1.4	-1.1	-0.7	-1.2
Compulsive drug intake	1.3	1.3	2.1	1.3	0.6	1.4	1.3	1.0	1.3	0.1	1.2	1.1	1.3	1.1	1.1	0.9	1.5	0.9
Total zone transitions, NPP test	1.3	1.8	2.6	1.2	1.5	1.0	0.4	1.6	1.5	1.6	1.3	1.6	0.9	1.4	1.4	1.5	1.4	1.5
Pavlov. Cond. index score	1.3	1.7	2.1	1.4	0.8	1.4	1.2	1.4	1.3	0.9	1.4	1.2	1.4	1.2	1.4	1.3	1.3	1.3
Bone: trabecular thickness	1.3	1.5	2.4	1.2	1.0	1.2	0.7	1.4	1.2	1.0	1.3	1.4	1.1	1.2	1.3	1.4	1.5	1.4
Time in closed arm after self-admin	1.3	1.3	2.2	1.3	-0.2	1.5	1.5	1.1	0.9	0.6	1.4	0.8	1.2	1.3	1.4	1.1	1.0	1.1
Locomotion velocity, session 3	1.2	1.4	2.6	1.2	0.5	1.4	1.4	1.1	1.4	0.5	1.2	0.9	1.6	1.0	1.2	1.1	1.3	1.2
Total locomotion distance, NPP test	1.2	1.7	3.3	1.1	1.5	0.7	-0.1	1.5	1.1	1.8	1.1	1.8	0.6	1.2	1.2	1.5	1.4	1.4
Pavlov. Cond. latency score	1.2	1.6	2.0	1.4	0.8	1.4	1.1	1.4	1.3	0.9	1.4	1.1	1.4	1.3	1.4	1.3	1.3	1.3
Bone: cortical thickness	1.2	1.4	3.2	1.0	1.1	0.9	0.3	1.3	1.1	1.0	1.1	1.8	1.1	1.1	1.1	1.2	1.7	1.2
Bone: tissue strength	1.2	1.2	2.8	-0.9	-1.2	-0.4	0.2	-1.2	-0.8	-1.7	-0.9	-1.6	-0.6	-1.0	-0.9	-1.3	-1.2	-1.1
Parametrial fat weight	1.1	2.1	3.7	-1.5	-1.3	-1.8	-1.7	-1.2	-1.9	-0.4	-1.5	-1.0	-1.7	-1.6	-1.5	-1.1	-1.6	-1.3
Stereotopy head waving duration, day 3	1.1	1.3	2.8	1.3	0.3	1.5	1.7	1.0	1.4	0.4	1.3	0.4	1.5	1.2	1.3	1.0	0.8	1.1
Delta ambulatory time before/after self-admin	1.1	1.2	1.9	1.2	1.1	0.8	0.4	1.2	0.8	1.3	1.1	1.4	0.8	1.4	1.2	1.2	1.2	1.1
Delay disc. indifference point, 16s delay	1.1	1.1	2.6	-1.1	-0.6	-1.5	-1.6	-0.8	-1.3	0.3	-1.1	-0.3	-1.5	-0.9	-1.1	-0.7	-0.9	-0.9
Locomotion velocity, session 2	1.0	1.2	2.6	-1.0	-1.6	-0.5	0.3	-1.2	-0.7	-1.4	-1.0	-1.5	-0.4	-1.0	-1.0	-1.3	-1.3	-1.2
Locomotion velocity, NPP test	1.0	1.5	3.5	1.0	1.4	0.5	-0.3	1.5	0.9	1.9	1.0	1.8	0.4	1.1	1.1	1.5	1.3	1.3
Pavlov. Cond. change in total contacts	1.0	1.0	1.9	-1.1	-0.2	-1.3	-1.4	-0.8	-1.2	-0.0	-1.1	-0.5	-1.3	-1.1	-1.0	-0.8	-1.1	-1.0
Pavlov. Cond. intertrial magazine entries	1.0	1.3	3.9	0.8	1.5	0.2	-0.8	1.2	0.6	1.8	0.7	2.0	0.1	0.8	0.9	1.3	1.2	1.1
Delta distance traveled before/after self-admin	1.0	1.1	2.1	1.0	0.9	0.7	0.2	1.2	0.6	1.4	1.1	1.4	0.6	1.3	1.1	1.1	1.1	1.1
Total resting periods, locomotor time 1	1.0	1.2	2.7	-1.2	-1.6	-0.7	-0.4	-1.2	-1.2	-1.4	-1.1	-0.9	-0.6	-0.9	-1.0	-1.2	-0.8	-1.2
Bouts of movement, locomotor time 2	1.0	1.1	4.1	0.2	1.3	0.0	-0.9	1.1	0.1	2.0	0.6	2.0	-0.0	0.7	0.8	1.1	0.9	0.8
Sr content in liver	1.0	0.9	2.2	-1.2	-0.0	-1.3	-1.5	-0.8	-0.9	-0.2	-1.1	-0.3	-1.3	-0.9	-1.1	-0.8	-0.6	-0.9
Tibialis anterior weight	0.9	3.1	4.3	-2.0	-0.8	-2.1	-2.1	-1.8	-2.0	-0.8	-2.0	-1.2	-2.1	-1.9	-1.9	-1.7	-1.6	-1.8
Short access day 1 total inactive lever presses	0.9	1.0	3.2	-1.3	0.2	-1.5	-1.8	-0.5	-1.2	0.8	-1.0	-0.2	-1.4	-0.8	-0.9	-0.4	-1.2	-0.7
Context. condit. distance diff. score	0.9	1.0	3.3	0.9	-0.5	1.5	1.8	0.5	1.0	-0.5	1.0	0.3	1.6	0.8	1.0	0.5	1.0	0.7
Area under the delay curve	0.9	0.9	4.3	-0.7	0.5	-1.4	-2.1	-0.1	-1.1	1.3	-0.7	1.0	-1.3	-0.5	-0.6	-0.0	-0.0	-0.3
Delay disc. indifference point, 2s delay	0.9	1.0	4.6	0.4	2.1	-0.7	-1.5	0.6	0.2	1.5	0.0	1.9	-0.5	0.3	0.0	0.6	1.1	0.4
Delay disc. indifference point, 4s delay	0.9	1.0	4.6	-0.7	0.9	-1.3	-2.1	0.1	-1.0	1.5	-0.5	1.4	-1.1	-0.3	-0.4	0.1	0.3	-0.2
Delay discount hyperbolic model param	0.9	0.9	4.5	0.7	-0.6	1.3	2.1	0.0	1.1	-1.4	0.6	-1.3	1.2	0.4	0.5	-0.1	-0.2	0.2
Food seeking constrained by brief footshock	0.9	1.1	5.1	0.0	1.7	-0.6	-1.4	0.9	-0.0	2.2	0.2	1.4	-0.7	0.7	0.3	0.9	0.5	0.7
Run reversals in cocaine runway, females	0.9	0.9	2.9	0.6	0.4	0.7	0.3	1.0	0.7	0.8	0.8	1.7	1.0	1.0	0.9	0.9	1.5	0.8
K content in liver	0.9	0.9	2.7	0.5	1.7	0.1	-0.7	1.0	0.7	1.6	0.5	1.2	0.1	0.8	0.6	1.1	0.7	0.9
Mean time between licks in bursts	0.8	1.1	1.6	-1.1	-0.8	-0.9	-0.5	-1.2	-1.0	-1.0	-1.2	-1.0	-0.8	-0.8	-1.1	-1.2	-1.2	-1.2
Mean num. licks in bursts	0.8	1.0	3.8	0.1	-1.6	1.0	2.0	-0.4	0.2	-1.5	0.2	-1.7	0.8	0.3	0.1	-0.5	-0.7	-0.2
Reaction time mean AUC	0.8	1.1	1.7	1.2	0.0	1.3	1.3	1.0	1.1	0.4	1.1	0.7	1.2	1.2	1.2	1.0	1.2	1.1
Reaction time premature initiations	0.8	1.1	2.0	1.2	0.6	1.3	1.4	1.1	1.3	0.3	1.1	0.4	1.4	1.1	1.1	0.9	0.8	0.9
Pavlov. Cond. lever latency	0.8	1.0	4.8	-0.7	1.0	-1.5	-2.2	-0.2	-0.9	1.3	-0.8	0.4	-1.6	-0.5	-0.7	-0.1	-0.5	-0.3
Intermittent access day 1 total infusions	0.8	0.9	1.4	1.1	0.5	0.7	0.5	1.0	0.5	1.1	0.9	1.1	1.0	1.2	1.0	1.0	1.0	0.9
Intermittent access terminal intake (last 3 days)	0.8	0.9	2.6	-0.8	-1.6	-0.5	-0.2	-1.1	-0.9	-1.4	-0.8	-0.9	-0.3	-1.0	-0.9	-0.9	-0.7	-0.9
Locomotion distance, session 2	0.8	1.1	1.5	1.2	0.4	1.2	1.2	1.2	1.2	0.7	1.2	0.6	1.1	1.1	1.2	1.1	0.8	1.1
Degree of sensitization distance	0.8	0.8	2.8	0.9	-0.5	1.4	1.7	0.5	0.9	-0.4	1.0	0.2	1.3	0.8	0.8	0.5	0.9	0.7
Time in familiar zone, hab. session 2	0.8	0.8	1.7	1.0	0.0	1.2	1.3	0.8	1.0	0.2	1.0	0.3	1.1	1.0	1.0	0.8	0.8	0.9
Pavlov. Cond. lever latency	0.8	1.0	1.4	-1.1	-1.0	-0.9	-0.5	-1.2	-1.0	-1.0	-1.0	-1.2	-0.9	-1.0	-1.1	-1.2	-1.1	-1.1
Pavlov. Cond. magazine entry latency	0.8	1.1	1.8	1.2	0.4	1.3	1.3	1.0	1.1	0.4	1.2	0.8	1.4	1.0	1.1	0.9	1.0	1.0
Bone: cortical area	0.8	1.3	3.9	-1.2	0.4	-1.6	-2.0	-0.8	-1.3	0.2	-1.2	-0.3	-1.6	-1.0	-1.2	-0.7	-1.0	-0.8
Time to tail flick, test, after self-admin	0.8	0.8	3.0	-0.4	1.7	-1.4	-1.7	0.1	-0.4	1.4	-0.6	0.6	-1.1	-0.4	-0.5	0.0	-0.6	-0.3
Delay discount exponential model param	0.8	0.9	4.0	0.6	-0.4	1.3	2.0	0.0	1.0	-1.3	0.6	-1.1	1.2	0.5	0.5	-0.0	-0.1	0.3
Vertical activity count, locomotor time 2	0.8	0.9	1.5	1.0	0.9	0.8	0.8	1.1	1.2	0.6	0.9	1.0	0.9	1.0	0.8	0.9	1.2	1.0
Pavlov. Cond. lever contacts	0.7	1.0	4.3	0.8	-1.0	1.5	2.1	0.3	0.9	-1.1	0.9	-0.1	1.6	0.5	0.8	0.2	0.6	0.4
Intermittent access standard deviation	0.7	0.8	3.9	0.2	-2.0	0.7	1.4	-0.5	0.1	-1.5	0.0	-1.2	0.8	-0.1	-0.1	-0.4	-0.4	-0.3
Progressive ratio test 1 inactive lever presses	0.7	0.7	3.5	-0.4	1.5	-1.1	-1.5	0.3	-0.5	1.9	-0.3	0.4	-0.9	0.1	-0.1	0.3	-0.6	0.0
Short access day 1 total infusions	0.7	0.8	1.4	0.7	0.1	0.9	0.8	1.0	0.5	1.2	1.1	0.5	0.9	1.1	1.1	1.0	0.5	1.0
Condit. Reinf. active responses	0.7	0.9	1.3	-1.1	-0.7	-1.0	-1.0	-0.9	-1.1	-0.4	-1.0	-0.6	-1.0	-1.0	-1.0	-0.9	-1.0	-0.9
Time in novel zone, NPP test	0.7	0.7	1.2	-0.7	-1.0	-0.7	-0.2	-0.9	-0.8	-0.9	-0.8	-1.1	-0.6	-0.8	-0.8	-0.9	-1.0	-0.9
Delta time to tail flick, test, before/after SA	0.7	0.6	2.4	-0.6	0.2	-1.1	-1.5	0.0	-1.0	1.4	-0.4	0.3	-1.2	-0.3	-0.4	0.1	-0.5	-0.1
Cu content in liver	0.7	0.8	1.6	-1.0	-0.4	-0.8	-0.6	-0.9	-0.9	-0.7	-0.9	-1.2	-1.0	-0.8	-0.9	-0.9	-1.3	-0.9
Left kidney weight	0.6	1.6	3.5	1.0	1.5	0.7	0.0	1.4	1.0	1.6	1.1	1.9	0.9	1.2	1.1	1.4	1.7	1.4
Tibia length	0.6	1.7	3.6	1.1	1.9	0.8	0.1	1.4	1.4	1.3	1.1	1.8	0.8	1.0	1.1	1.4	1.6	1.4
Indifference point AUC	0.6	0.7	1.4	-0.9	-1.2	-0.5	-0.3	-0.9	-0.9	-0.9	-0.7	-0.8	-0.5	-1.2	-0.7	-0.8	-0.9	-0.9
Delay discounting time to switch 0 sec	0.6	0.9	1.3	1.1	0.7	1.0	0.8	0.9	0.9	0.7	1.0	0.7	0.9	1.1	1.1	1.0	1.0	1.0
Post-drug Anxiety	0.6	0.7	1.2	-0.7	-0.1	-1.1	-0.9	-0.8	-0.6	-0.5	-1.0	-0.5	-0.9	-1.0	-1.0	-0.8	-1.0	-0.9
Pavlov. Cond. lever contacts	0.6	0.7	1.0	0.9	0.6	0.7	0.6	1.0	0.7	0.8	0.9	0.7	0.7	0.9	1.0	1.0	0.7	0.9
Bone: final moment	0.6	1.0	1.5	-1.0	-0.5	-1.1	-1.0	-1.0	-1.1	-0.8	-1.1	-0.9	-1.2	-1.0	-1.1	-1.0	-1.2	-1.0
Diff in mean of infusions in LGA sessions	0.6	0.6	1.0	0.7	0.2	0.6	0.4	0.9	0.5	1.0	0.8	0.9	0.7	1.0	0.8	0.9	1.0	0.9
Delay disc. indifference point, 24s delay	0.6	0.6	1.9	-0.5	-0.1	-1.3	-1.4	-0.5	-0.8	0.3	-0.8	0.0	-1.2	-0.8	-0.9	-0.4	-0.5	-0.6
Total resting periods, locomotor time 2	0.6	0.6	2.7	-0.1	0.8	-0.2	-1.0	0.7	-0.2	1.6	0.3	1.6	-0.2	0.3	0.5	0.7	0.6	0.4
Progressive ratio	0.6	0.7	1.1	0.9	0.7	0.6	0.7	1.0	0.9	1.0	0.9	0.4	0.6	1.0	0.8	0.9	0.7	1.0
Co content in liver	0.6	0.7	1.1	-1.0	-0.8	-0.7	-0.5	-0.9	-0.9	-0.7	-0.8	-0.8	-0.8	-1.0	-0.8	-0.8	-0.9	-0.8
Se content in liver	0.6	0.7	2.1	-0.8	0.6	-1.2	-1.4	-0.5	-0.7	0.5	-0.9	-0.3	-1.2	-0.8	-0.8	-0.4	-0.9	-0.6
Body weight	0.5	2.0	7.2	-1.4	0.9	-2.0	-2.7	-0.9	-1.5	0.5	-1.4	-0.0	-2.1	-1.3	-1.4	-0.8	-0.9	-1.0
Tail length	0.5	1.4	3.7	-1.2	0.0	-1.8	-1.9	-0.8	-1.4	0.4	-1.3	-0.4	-1.6	-1.2	-1.2	-0.7	-1.3	-1.0
Length with tail	0.5	2.0	7.6	-1.4	0.8	-2.2	-2.8	-0.7	-1.5	0.9	-1.4	0.3	-2.0	-1.3	-1.4	-0.6	-1.0	-0.9
Reaction time number correct	0.5	0.7	1.3	-0.9	-1.1	-0.5	-0.2	-0.9	-0.8	-0.9	-0.8	-1.0	-0.5	-0.6	-0.8	-0.9	-0.9	-0.9
Reaction time trials correct on left	0.5	0.7	1.3	-0.9	-1.1	-0.5	-0.2	-0.9	-0.8	-0.9	-0.8	-1.0	-0.5	-0.6	-0.8	-0.9	-0.9	-0.9
Reaction time trials on left	0.5	0.6	1.3	-0.9	-1.1	-0.5	-0.2	-0.9	-0.8	-0.9	-0.7	-0.9	-0.4	-0.6	-0.8	-0.9	-0.9	-0.8
Reaction time false alarm rate	0.5	0.7	2.7	0.5	1.7	-0.3	-1.0	0.7	0.3	1.2	0.2	1.3	-0.4	0.4	0.3	0.7	0.9	0.5
Reaction time trials completed	0.5	0.6	1.3	-0.9	-1.1	-0.5	-0.2	-0.9	-0.8	-0.9	-0.7	-0.9	-0.4	-0.6	-0.8	-0.9	-0.9	-0.8
Social response proportion	0.5	0.6	1.4	-0.7	0.3	-1.0	-1.1	-0.5	-0.9	0.4	-0.7	-0.7	-1.2	-0.7	-0.7	-0.4	-1.1	-0.5
Cocaine response after cond. corrected	0.5	0.6	1.7	-0.8	0.4	-1.1	-1.3	-0.6	-0.7	0.0	-0.9	0.2	-0.8	-0.7	-0.8	-0.6	-0.4	-0.8
Cocaine response before conditioning	0.5	0.6	0.8	0.7	0.7	0.8	0.5	0.8	0.9	0.6	0.8	0.6	0.7	0.8	0.8	0.8	0.9	0.8
Pavlov. Cond. magazine entry number	0.5	0.6	1.6	0.6	1.1	0.3	-0.2	0.9	0.5	1.2	0.6	1.0	0.2	0.8	0.7	0.9	0.7	0.9
Short access day 10 total infusions	0.5	0.6	0.9	0.9	0.4	0.8	0.6	0.7	0.5	0.7	0.8	0.8	0.9	0.9	0.9	0.8	0.8	0.7
Novel to familiar place preference ratio	0.5	0.5	1.3	-0.6	-1.1	-0.6	-0.3	-0.7	-0.8	-0.6	-0.7	-0.7	-0.5	-0.7	-0.7	-0.7	-0.7	-0.7
Novelty place preference	0.5	0.6	1.2	-0.6	-1.1	-0.6	-0.2	-0.8	-0.8	-0.7	-0.7	-0.9	-0.5	-0.7	-0.7	-0.8	-0.9	-0.8
Pavlov. Cond. magazine entry number	0.5	0.6	1.6	-0.8	0.2	-1.1	-1.2	-0.6	-0.8	-0.0	-0.9	-0.4	-1.2	-0.6	-0.8	-0.5	-0.7	-0.6
Bone: cortical tissue density	0.5	0.7	0.9	-0.9	-0.2	-1.0	-0.9	-0.8	-1.0	-0.2	-0.9	-0.6	-0.9	-0.8	-0.9	-0.7	-0.9	-0.8
Bone: final force	0.5	0.9	1.4	-0.9	-0.6	-1.0	-0.8	-0.9	-1.0	-0.8	-1.0	-0.9	-1.0	-0.9	-1.1	-1.0	-1.2	-1.0
Active lever presses in extinction session 6	0.5	0.5	2.6	1.0	1.6	0.1	-0.1	0.6	0.7	1.0	0.4	0.5	0.4	0.7	0.4	0.6	0.5	0.6
Time in closed arm before self-admin	0.5	0.6	0.9	-0.5	0.1	-0.8	-0.7	-0.8	-0.6	-0.8	-0.9	-0.6	-0.8	-0.9	-0.9	-0.9	-0.9	-0.9
Time to tail flick, test, before self-admin	0.5	0.4	2.8	0.0	-0.3	0.4	0.9	-0.6	0.4	-1.7	-0.2	-0.9	0.6	-0.4	-0.3	-0.7	-0.3	-0.5
Mn content in liver	0.5	0.6	2.1	0.6	1.3	0.1	-0.4	0.8	0.5	1.4	0.5	1.1	0.1	0.4	0.6	0.9	0.5	0.8
Heart weight	0.4	0.6	3.6	-0.5	-1.9	0.0	0.5	-0.8	-0.7	-1.3	-0.4	-0.9	0.1	-0.6	-0.5	-0.8	-0.3	-0.6
Intraocular pressure	0.4	0.6	1.3	-0.9	-1.0	-0.7	-0.7	-0.7	-0.9	-0.6	-0.8	-0.5	-0.6	-1.1	-0.8	-0.7	-0.7	-0.8
Indifference point function ln k	0.4	0.5	1.3	0.6	1.2	0.3	-0.1	0.8	0.6	1.1	0.6	0.8	0.2	0.8	0.6	0.8	0.7	0.7
Indifference point function log k	0.4	0.5	1.3	0.6	1.2	0.3	-0.1	0.8	0.6	1.1	0.6	0.8	0.2	0.8	0.6	0.8	0.7	0.7
Reaction time mean minus median	0.4	0.6	2.4	0.3	-1.2	1.1	1.6	-0.1	0.4	-1.3	0.4	-0.5	1.0	0.4	0.3	-0.2	0.4	0.1
Reaction time mean	0.4	0.5	1.1	0.9	-0.3	1.0	1.0	0.6	0.8	0.2	0.8	0.3	0.8	0.8	0.8	0.6	0.8	0.8
Median of all reaction times	0.4	0.6	0.9	0.9	0.0	0.8	0.8	0.8	0.8	0.7	0.9	0.5	0.6	0.8	0.9	0.9	0.7	1.0
Reaction time trials AUC	0.4	0.6	1.2	-1.0	-1.1	-0.5	-0.3	-0.9	-0.8	-0.8	-0.8	-0.9	-0.5	-0.6	-0.8	-0.9	-0.9	-0.8
Social time	0.4	0.6	1.1	-1.0	-0.4	-0.7	-0.6	-0.7	-0.9	-0.3	-0.7	-1.1	-1.0	-0.6	-0.6	-0.6	-1.0	-0.6
Cocaine response after cond. not corrected	0.4	0.5	1.9	-0.7	0.8	-1.0	-1.4	-0.4	-0.5	0.3	-0.8	0.4	-0.8	-0.6	-0.7	-0.4	-0.2	-0.6
Pavlov. Cond. index score	0.4	0.5	1.7	0.6	-0.3	1.0	1.3	0.4	0.8	-0.5	0.7	0.2	1.1	0.4	0.6	0.3	0.6	0.4
Pavlov. Cond. latency score	0.4	0.5	1.5	0.7	-0.0	1.1	1.2	0.5	0.9	-0.3	0.8	0.4	1.1	0.4	0.7	0.4	0.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.6	0.6	-0.2	1.0	1.3	0.4	0.8	-0.4	0.7	0.2	1.1	0.4	0.6	0.3	0.6	0.4
Baseline Anxiety	0.4	0.5	1.4	0.6	0.2	0.7	0.4	0.5	0.2	0.4	0.7	1.1	0.7	0.8	0.7	0.6	1.2	0.7
Locomotion distance, session 3	0.4	0.4	0.6	-0.7	-0.3	-0.7	-0.7	-0.6	-0.6	-0.3	-0.7	-0.4	-0.7	-0.7	-0.7	-0.6	-0.7	-0.6
Stereotopy head waving bouts, day 3	0.4	0.5	0.7	0.7	0.4	0.8	0.9	0.7	0.8	0.5	0.8	0.2	0.8	0.8	0.8	0.7	0.3	0.7
Total locomotion distance, hab. session 1	0.4	0.5	1.7	0.3	1.0	0.1	-0.4	0.8	0.6	1.3	0.4	1.3	0.3	0.5	0.5	0.8	0.8	0.7
Bone: cortical apparent density	0.4	0.5	0.8	-0.9	-0.1	-0.9	-0.9	-0.7	-0.9	-0.1	-0.8	-0.5	-0.9	-0.7	-0.8	-0.7	-0.8	-0.7
Bone: cortical thickness	0.4	0.7	3.0	-0.8	0.9	-1.3	-1.7	-0.4	-0.8	0.4	-0.8	0.1	-1.2	-0.6	-0.8	-0.4	-0.6	-0.5
Bone: elastic displacement	0.4	0.5	1.0	0.8	0.5	0.8	1.0	0.6	0.9	0.1	0.7	0.1	0.8	0.8	0.7	0.6	0.6	0.7
Bone: periosteal perimeter	0.4	0.6	2.9	-0.7	0.4	-1.1	-1.7	-0.3	-1.0	0.9	-0.6	0.4	-1.0	-0.5	-0.6	-0.1	-0.2	-0.2
Distance traveled before self-admin	0.4	0.4	0.8	-0.7	0.1	-0.6	-0.3	-0.7	-0.0	-0.9	-0.8	-0.8	-0.3	-0.7	-0.8	-0.8	-0.8	-0.7
Extinction: sum of active levers before priming	0.4	0.4	1.0	-0.4	-1.0	-0.7	-0.5	-0.5	-1.0	0.2	-0.5	-0.8	-0.4	-0.3	-0.5	-0.3	-0.9	-0.3
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.5	0.5	1.2	-0.1	-0.4	0.8	0.8	1.2	0.3	0.9	-0.2	0.7	0.4	0.6	0.5	0.5
Delay disc. indifference point, 8s delay	0.4	0.4	1.8	-0.2	0.6	-0.5	-1.1	0.5	-0.2	1.4	0.0	1.1	-0.5	-0.0	0.1	0.5	0.3	0.2
Rest time, locomotor task time 2	0.4	0.4	1.3	-0.5	-1.1	-0.2	0.2	-0.8	-0.5	-1.0	-0.5	-1.1	-0.3	-0.5	-0.5	-0.7	-0.7	-0.6
Seeking ratio, punishment vs. effort	0.4	0.5	2.2	-0.7	0.7	-0.9	-1.5	-0.3	-0.8	0.5	-0.6	0.6	-1.0	-0.5	-0.5	-0.2	-0.3	-0.5
Run reversals in cocaine runway, males	0.4	0.4	0.6	-0.8	-0.5	-0.6	-0.4	-0.6	-0.6	-0.5	-0.6	-0.7	-0.6	-0.5	-0.6	-0.6	-0.8	-0.6
Latency to leave start box in cocaine runway, F	0.4	0.4	2.5	-0.3	1.6	-0.7	-1.2	-0.1	0.2	0.3	-0.4	0.6	-0.6	-0.3	-0.4	-0.1	0.3	-0.2
Epididymis fat weight	0.3	0.6	1.2	0.8	0.7	0.9	0.8	0.7	1.0	0.2	0.8	0.6	0.9	0.8	0.8	0.7	1.1	0.8
Length without tail	0.3	0.6	2.5	-0.7	1.0	-1.2	-1.6	-0.4	-0.7	0.5	-0.8	0.3	-1.2	-0.6	-0.7	-0.3	-0.4	-0.5
Reaction time mean minus median AUC	0.3	0.4	1.8	0.4	-0.7	0.9	1.3	-0.1	0.6	-1.1	0.4	-0.1	1.0	0.3	0.3	-0.2	0.5	0.0
Reaction time num false alarms AUC	0.3	0.4	1.5	0.1	1.2	-0.6	-1.2	0.2	-0.1	0.8	-0.1	0.9	-0.6	0.1	-0.1	0.3	0.5	0.1
Reaction time omissions	0.3	0.4	0.8	0.6	-0.3	0.9	0.9	0.4	0.6	-0.1	0.7	0.4	0.8	0.5	0.6	0.4	0.8	0.5
Std. dev. reaction times	0.3	0.5	1.7	0.6	-0.8	1.0	1.3	0.1	0.5	-0.7	0.6	-0.1	1.0	0.6	0.5	0.1	0.7	0.4
Condit. Reinf. active responses	0.3	0.4	0.8	0.6	0.2	0.9	0.9	0.6	0.7	0.1	0.8	0.2	0.8	0.6	0.8	0.6	0.4	0.6
Condit. Reinf. inactive responses	0.3	0.4	1.6	0.6	-0.1	1.0	1.3	0.4	0.8	-0.5	0.6	-0.2	0.9	0.6	0.6	0.2	0.2	0.3
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	0.6	0.3	0.8	0.8	0.6	0.7	0.1	0.7	0.3	0.7	0.6	0.7	0.5	0.5	0.5
Pavlov. Cond. response bias	0.3	0.5	2.0	0.2	-1.1	0.8	1.4	-0.2	0.4	-1.3	0.3	-0.4	1.0	-0.1	0.2	-0.3	0.1	-0.2
Intermittent access day 15 total infusions	0.3	0.3	1.3	-0.6	-1.1	-0.4	-0.4	-0.6	-0.6	-0.6	-0.6	-0.5	-0.3	-0.6	-0.6	-0.5	-0.4	-0.5
Incentive Sensitization - Breakpoint	0.3	0.3	1.1	-0.5	-1.1	-0.1	-0.1	-0.6	-0.5	-0.9	-0.4	-0.3	0.0	-0.5	-0.4	-0.5	0.1	-0.3
Progressive ratio test 1 breakpoint	0.3	0.3	0.5	0.5	-0.4	0.5	0.4	0.5	-0.0	0.6	0.6	0.6	0.6	0.7	0.6	0.6	0.4	0.4
Short access day 10 total inactive lever presses	0.3	0.4	0.7	0.4	0.6	0.5	0.3	0.8	0.6	0.8	0.6	0.6	0.5	0.8	0.7	0.7	0.4	0.6
Short access total infusions	0.3	0.4	0.6	0.6	0.2	0.8	0.7	0.6	0.5	0.4	0.7	0.3	0.8	0.7	0.7	0.6	0.5	0.6
Locomotion velocity, session 7	0.3	0.3	0.6	-0.8	-0.3	-0.6	-0.5	-0.6	-0.5	-0.4	-0.6	-0.4	-0.5	-0.6	-0.6	-0.6	-0.6	-0.6
Stereotopy head waving bouts, day 7	0.3	0.3	1.2	0.4	-0.8	0.7	0.9	0.2	0.3	0.0	0.5	0.3	1.1	0.3	0.5	0.3	0.6	0.4
Locomotion velocity, session 8	0.3	0.4	1.7	0.0	-1.3	0.7	1.2	-0.3	0.2	-1.0	0.1	-0.3	0.8	-0.1	0.1	-0.3	0.1	-0.2
Condit. Reinf. lever presses	0.3	0.4	1.6	0.1	0.8	-0.4	-1.1	0.4	-0.3	1.3	0.0	0.9	-0.4	0.1	0.1	0.5	0.2	0.4
Locomotion velocity, hab. session 1	0.3	0.5	1.5	0.5	0.9	0.3	-0.1	0.8	0.7	1.0	0.5	1.2	0.4	0.5	0.6	0.8	0.9	0.7
Locomotion velocity, hab. session 2	0.3	0.4	1.8	-0.4	0.7	-0.8	-1.4	0.3	-0.3	1.3	-0.3	0.7	-0.9	-0.1	-0.1	0.3	-0.1	0.1
Pavlov. Cond. response bias	0.3	0.3	0.5	0.6	0.4	0.6	0.6	0.7	0.6	0.4	0.7	0.4	0.7	0.6	0.7	0.6	0.4	0.6
Bone: periosteal estimation	0.3	0.5	1.7	-0.8	0.1	-1.1	-1.3	-0.5	-0.8	0.1	-0.8	-0.1	-1.0	-0.7	-0.8	-0.5	-0.6	-0.6
Bone: trabecular spacing	0.3	0.4	1.0	-0.7	-0.1	-0.9	-1.0	-0.6	-0.7	0.0	-0.7	-0.1	-0.9	-0.7	-0.7	-0.5	-0.5	-0.6
Breakpoint value in progressive ratio session	0.3	0.4	1.0	-0.4	0.7	-1.0	-1.0	-0.4	-0.2	0.2	-0.7	-0.4	-0.7	-0.5	-0.7	-0.4	-0.7	-0.5
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.1	-0.5	0.4	-0.9	-1.0	-0.2	-0.4	0.5	-0.5	-0.2	-0.7	-0.3	-0.5	-0.2	-0.4	-0.3
Ambulatory time before self-admin	0.3	0.3	0.6	-0.8	0.3	-0.7	-0.7	-0.5	-0.1	-0.4	-0.7	-0.3	-0.5	-0.7	-0.7	-0.6	-0.6	-0.6
Ambulatory time after self-admin	0.3	0.3	2.2	0.2	1.5	-0.3	-0.4	0.5	0.5	0.9	0.1	0.5	0.0	0.4	0.1	0.4	0.0	0.3
Delay disc. indifference point, 0s delay	0.3	0.4	1.4	-0.3	1.1	-0.6	-1.2	-0.1	-0.2	0.2	-0.4	1.0	-0.5	-0.1	-0.4	-0.1	0.7	-0.2
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	0.7	0.8	0.5	0.5	0.6	0.7	0.5	0.6	0.3	0.4	0.6	0.6	0.5	0.3	0.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.5	0.4	-0.3	0.7	0.7	0.4	0.4	-0.1	0.6	0.2	0.6	0.6	0.5	0.4	0.7	0.6
Distance moved, locomotor task time 2	0.3	0.4	0.5	0.6	0.4	0.6	0.5	0.7	0.7	0.5	0.7	0.6	0.5	0.6	0.6	0.7	0.7	0.6
Soleus weight	0.2	0.6	2.4	0.0	1.6	-0.7	-1.4	0.3	-0.3	1.4	-0.1	0.7	-0.6	0.2	-0.1	0.5	0.2	0.3
Reaction time num false alarms	0.2	0.3	1.4	-0.3	0.8	-0.7	-1.2	-0.2	-0.5	0.3	-0.4	0.3	-0.8	-0.2	-0.4	-0.1	-0.0	-0.3
Condit. Reinf. lever presses	0.2	0.2	0.5	0.4	0.1	0.7	0.6	0.4	0.5	0.0	0.5	0.5	0.7	0.4	0.5	0.4	0.6	0.4
Conditioned locomotion	0.2	0.3	2.0	-0.4	-1.4	-0.0	-0.1	-0.1	-1.1	0.6	0.1	-0.4	-0.1	0.1	0.2	0.2	-0.5	0.1
Intermittent access day 15 total locomotion	0.2	0.2	1.0	-0.3	-0.9	-0.1	-0.3	0.3	-0.6	1.0	0.2	-0.1	-0.2	0.3	0.3	0.4	-0.1	0.4
Intermittent access total locomotion	0.2	0.3	1.6	-0.1	-0.8	-0.1	-0.3	0.4	-0.7	1.3	0.3	0.3	-0.0	0.4	0.4	0.6	0.0	0.5
Incentive Sensitization - Responses	0.2	0.2	1.1	-0.5	-1.0	-0.1	-0.1	-0.5	-0.6	-0.7	-0.3	-0.3	-0.0	-0.4	-0.4	-0.4	0.1	-0.3
Progressive ratio test 2 inactive lever presses	0.2	0.3	1.2	-0.5	-0.9	-0.6	-0.8	-0.2	-1.1	0.6	-0.3	-0.1	-0.5	-0.1	-0.2	-0.1	-0.4	-0.1
Number of responses in last shaping day	0.2	0.2	0.6	0.0	0.6	0.3	-0.2	0.5	0.3	0.7	0.4	0.8	0.3	0.4	0.5	0.5	0.5	0.4
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.3	-0.1	0.3	0.3	0.4	0.3	0.8	0.4	0.5	0.7	0.3	0.4	0.5	0.4	0.5
Condit. Reinf. inactive responses	0.2	0.2	0.8	-0.0	0.6	-0.3	-0.8	0.3	-0.2	0.9	0.0	0.9	-0.3	-0.0	0.1	0.4	0.3	0.2
Time in novel zone, hab. session 1	0.2	0.2	0.7	-0.4	0.1	-0.4	-0.2	-0.6	-0.3	-0.4	-0.4	-0.8	-0.5	-0.4	-0.5	-0.6	-0.7	-0.5
Total zone transitions, hab. session 2	0.2	0.2	0.9	-0.2	0.6	-0.6	-0.9	0.3	-0.1	0.9	-0.2	0.4	-0.7	-0.0	-0.1	0.2	-0.3	0.1
Total locomotion distance, hab. session 2	0.2	0.3	1.4	-0.5	0.3	-0.8	-1.2	0.1	-0.4	0.9	-0.4	0.3	-0.9	-0.2	-0.3	0.1	-0.3	-0.1
Bone surface	0.2	0.3	0.6	-0.6	-0.1	-0.7	-0.6	-0.5	-0.3	-0.5	-0.7	-0.3	-0.5	-0.7	-0.8	-0.6	-0.5	-0.7
Bone volume	0.2	0.3	0.5	-0.6	0.2	-0.7	-0.7	-0.5	-0.3	-0.4	-0.6	-0.3	-0.6	-0.6	-0.7	-0.5	-0.5	-0.6
Bone: elastic work	0.2	0.2	1.2	0.4	1.1	0.0	-0.2	0.5	0.5	0.5	0.2	0.5	-0.0	0.3	0.3	0.4	0.4	0.4
Bone: maximum force	0.2	0.3	0.6	-0.5	-0.1	-0.7	-0.7	-0.5	-0.6	-0.3	-0.6	-0.3	-0.7	-0.6	-0.6	-0.5	-0.6	-0.5
Bone: maximum moment	0.2	0.4	0.9	-0.6	-0.0	-0.8	-0.9	-0.5	-0.7	-0.2	-0.7	-0.3	-0.9	-0.6	-0.6	-0.5	-0.6	-0.6
Bone: trabecular tissue density	0.2	0.2	1.7	-0.1	-1.3	0.5	0.7	-0.2	-0.2	-0.6	0.1	-0.4	0.4	-0.0	0.2	-0.2	-0.0	-0.1
Time in open arm after self-admin	0.2	0.2	0.5	-0.6	0.2	-0.5	-0.3	-0.3	0.1	-0.3	-0.4	-0.6	-0.2	-0.5	-0.5	-0.4	-0.7	-0.4
Rest time, locomotor task time 1	0.2	0.2	1.5	-0.4	-1.2	0.0	0.2	-0.4	-0.5	-0.4	-0.1	-0.3	-0.1	-0.0	-0.1	-0.3	-0.2	-0.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	0.3	-0.7	0.6	0.7	0.2	0.0	0.1	0.4	-0.4	0.4	0.3	0.5	0.3	-0.2	0.3
Cd content in liver	0.2	0.2	0.3	0.4	0.4	0.5	0.4	0.4	0.3	0.5	0.5	0.1	0.4	0.4	0.6	0.5	0.2	0.5
Zn content in liver	0.2	0.2	1.0	-0.1	1.0	-0.1	-0.6	0.4	0.0	1.0	0.1	0.4	-0.2	0.4	0.2	0.5	0.0	0.3
Retroperitoneal fat weight	0.1	0.3	0.7	0.3	0.6	0.2	-0.3	0.6	0.2	0.7	0.4	0.8	-0.0	0.3	0.5	0.6	0.7	0.6
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.2	-0.4	-0.3	-0.3	-0.4	0.1	-0.1	-0.2	-0.3	-0.4	-0.2	-0.5
Delay discounting water rate 12 sec	0.1	0.2	0.4	-0.6	-0.1	-0.4	-0.5	-0.3	-0.4	-0.2	-0.5	-0.2	-0.5	-0.2	-0.4	-0.5	-0.5	-0.5
Delay discounting water rate 24 sec	0.1	0.1	0.4	-0.2	-0.3	-0.2	-0.1	-0.1	-0.3	0.1	-0.1	-0.5	-0.2	0.2	-0.2	-0.1	-0.6	-0.1
Delay discounting water rate 6 sec	0.1	0.2	1.0	-0.1	0.7	-0.1	-0.6	0.4	0.0	1.0	0.1	0.5	-0.4	-0.0	0.2	0.3	-0.2	0.2
Locomotor testing distance	0.1	0.2	0.5	-0.4	0.4	-0.3	-0.7	-0.2	-0.3	0.0	-0.4	0.4	-0.6	-0.4	-0.2	-0.3	-0.0	-0.4
Saline control response	0.1	0.1	0.5	-0.2	-0.7	0.3	0.6	-0.2	-0.0	-0.6	0.0	-0.4	0.3	-0.2	-0.1	-0.3	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	0.4	-0.0	0.6	0.6	0.4	0.4	0.0	0.5	0.2	0.6	0.3	0.5	0.4	0.4	0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	0.3	-0.1	0.5	0.6	0.2	0.4	-0.2	0.3	0.1	0.5	0.0	0.3	0.1	0.2	0.2
Conditioned reinforcement - actives	0.1	0.1	0.5	-0.1	-0.7	0.1	0.1	0.0	-0.3	0.2	0.1	-0.2	0.2	0.1	0.1	0.1	-0.3	0.1
Intermittent access total infusions	0.1	0.1	0.4	-0.1	-0.6	-0.1	-0.1	-0.2	-0.4	-0.2	-0.2	-0.1	0.1	-0.1	-0.2	-0.1	-0.0	-0.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	0.2	-0.4	0.1	0.1	0.2	-0.3	0.4	0.2	0.4	0.2	0.3	0.2	0.3	0.1	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.7	-0.2	-0.8	-0.2	-0.1	-0.4	-0.5	-0.5	-0.3	-0.0	0.1	-0.2	-0.3	-0.3	0.0	-0.3
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.5	-0.3	0.2	0.3	0.3	-0.0	0.5	0.4	0.4	0.5	0.6	0.4	0.4	0.3	0.3
One hour access (shock baseline)	0.1	0.2	0.5	-0.2	-0.7	-0.6	-0.4	-0.2	-0.7	0.4	-0.3	-0.4	-0.2	-0.1	-0.3	-0.1	-0.6	-0.2
Locomotion velocity, session 1	0.1	0.1	0.4	-0.3	-0.6	0.1	0.5	-0.2	-0.0	-0.4	-0.1	-0.5	0.1	-0.2	-0.1	-0.3	-0.4	-0.2
Degree of sensitization stereotypy	0.1	0.1	0.5	-0.2	-0.7	-0.1	-0.1	-0.1	-0.3	0.3	-0.0	0.2	0.2	-0.2	-0.1	-0.0	0.1	-0.0
Bone: apparent density	0.1	0.1	0.3	0.2	0.6	0.2	0.1	0.3	0.4	0.1	0.3	0.4	0.2	0.2	0.2	0.3	0.3	0.3
Bone: connectivity density	0.1	0.1	0.4	0.4	0.4	0.4	0.5	0.3	0.6	-0.0	0.3	0.2	0.4	0.3	0.3	0.3	0.4	0.3
Bone: cortical porosity	0.1	0.2	0.2	0.4	0.2	0.4	0.3	0.4	0.3	0.2	0.5	0.4	0.4	0.4	0.5	0.4	0.5	0.4
Bone: endosteal perimeter	0.1	0.2	1.2	-0.2	0.3	-0.6	-1.1	0.0	-0.5	0.9	-0.2	0.6	-0.6	-0.2	-0.2	0.2	0.1	0.1
Bone: minimum diameter	0.1	0.2	0.4	0.4	0.6	0.3	0.1	0.5	0.4	0.6	0.5	0.2	0.3	0.6	0.5	0.6	0.3	0.6
Bone: post-yield work	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.5	-0.2	-0.5	0.1	-0.3	0.2	-0.3	-0.3	-0.2	-0.1	0.0	-0.2
Distance traveled after self-admin	0.1	0.1	0.7	-0.2	0.9	-0.4	-0.5	0.1	0.1	0.5	-0.1	0.2	-0.3	0.0	-0.1	0.0	-0.3	-0.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.9	0.3	1.0	0.1	-0.1	0.3	0.6	0.1	0.1	0.5	0.0	0.2	0.1	0.2	0.5	0.1
Total heroin consumption	0.1	0.1	0.5	-0.1	0.2	-0.5	-0.0	-0.1	0.3	-0.1	-0.3	-0.7	0.0	-0.2	-0.4	-0.2	-0.4	-0.2
Distance moved, locomotor task time 1	0.1	0.1	0.7	-0.2	0.4	-0.4	-0.5	0.1	-0.2	0.9	-0.0	0.0	-0.4	-0.2	-0.1	0.3	-0.2	0.2
Weight adjusted by age	0.1	0.1	0.4	-0.2	0.4	-0.4	-0.6	-0.0	-0.0	0.3	-0.2	0.3	-0.4	-0.1	-0.2	-0.1	0.0	-0.2
Latency to leave start box in cocaine runway	0.1	0.2	1.1	-0.0	1.1	-0.3	-0.7	0.1	0.2	0.4	-0.2	0.3	-0.4	-0.2	-0.1	0.1	0.1	0.0
Fe content in liver	0.1	0.1	0.5	0.3	-0.4	0.3	0.7	0.1	0.2	-0.2	0.3	-0.4	0.3	0.4	0.2	0.1	-0.1	0.1
Mg content in liver	0.1	0.1	0.4	-0.3	0.2	-0.4	-0.6	-0.2	-0.2	0.2	-0.3	-0.1	-0.5	-0.0	-0.3	-0.1	-0.3	-0.2
BMI with tail	0.0	0.0	0.2	-0.2	0.2	-0.1	-0.4	-0.2	-0.3	-0.2	-0.2	-0.2	-0.4	-0.2	-0.2	-0.2	-0.0	-0.1
BMI without tail	0.0	0.0	0.2	-0.2	-0.4	-0.1	-0.0	-0.1	-0.3	-0.2	-0.1	-0.4	-0.2	-0.1	-0.1	-0.1	-0.3	-0.1
Light reinforcement 1	0.0	0.1	0.3	-0.1	0.2	-0.3	-0.6	-0.0	-0.4	0.3	-0.1	0.3	-0.3	-0.1	-0.1	0.1	-0.0	-0.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.0	0.2	0.0	-0.2	0.2	0.0	0.4	0.2	0.4	-0.0	0.0	0.1	0.3	0.2	0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.0	-0.1	0.0	0.1	-0.0	0.0	-0.2	-0.0	0.2	0.2	-0.3	-0.1	-0.1	0.2	-0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.0	0.2	-0.1	-0.2	0.0	-0.1	0.1	-0.0	0.0	-0.2	0.2	0.0	0.1	-0.0	0.1
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.1	-0.0	-0.1	0.1	-0.1	0.1	0.2	-0.0	-0.1	-0.0	0.1	-0.1
Lifetime Intake	0.0	0.0	0.1	-0.0	-0.4	-0.1	-0.1	-0.1	-0.3	0.0	-0.1	-0.1	0.1	0.0	-0.0	-0.0	-0.0	-0.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.3	0.0	-0.5	-0.0	-0.1	-0.1	-0.2	-0.3	-0.1	0.3	0.3	0.1	-0.1	-0.1	0.3	-0.1
Total sessions with >9 infusions	0.0	0.0	0.2	-0.1	-0.4	0.1	0.2	-0.1	-0.2	-0.2	0.0	-0.1	0.1	-0.1	0.0	-0.0	-0.1	-0.1
Locomotion distance, session 7	0.0	0.0	0.3	-0.0	-0.5	0.2	0.3	-0.1	-0.0	-0.5	-0.0	-0.1	0.1	-0.1	-0.1	-0.2	0.2	-0.1
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1	0.1	-0.1	-0.1	0.1	0.3	0.2	-0.0	0.1	0.1	0.2	0.1
Total zone transitions, hab. session 1	0.0	0.0	0.2	-0.0	0.1	0.0	0.1	0.2	0.2	0.4	0.1	0.1	0.1	0.1	0.1	0.1	-0.0	0.1
Bone: cortical porosity	0.0	0.0	0.1	0.1	0.3	-0.0	-0.1	0.2	0.1	0.2	0.1	0.2	-0.0	0.1	0.1	0.2	0.1	0.1
Bone: endosteal estimation	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.4	-0.2	-0.3	-0.1	-0.3	0.1	-0.2	-0.4	-0.3	-0.2	-0.1	-0.2
Bone: marrow area	0.0	0.0	0.1	-0.2	-0.3	-0.2	-0.2	-0.1	-0.2	-0.1	-0.2	0.2	-0.1	-0.3	-0.2	-0.1	0.0	-0.2
Bone: stiffness	0.0	0.0	0.2	0.0	-0.4	0.1	0.2	-0.1	-0.2	-0.2	0.1	-0.1	0.1	-0.0	0.1	-0.0	-0.1	-0.0
Bone: trabecular number	0.0	0.0	0.1	0.1	0.4	0.0	0.1	0.1	0.3	-0.1	0.1	0.1	0.1	0.0	-0.0	0.0	0.2	0.0
Vertical activity count, locomotor time 1	0.0	0.0	0.3	-0.1	0.5	-0.3	-0.3	0.1	0.1	0.2	-0.1	-0.0	-0.1	-0.2	-0.2	-0.0	-0.1	-0.0

For each tested trait, stats based on TWAS chi² (squared Z-score) for the above models are shown. Avg chi² ratio is the mean chi² across all models for this gene, divided by the mean chi² across all models for all genes. Avg chi² is the mean chi² across all models for this gene. Max chi² is the highest chi² across all models for this gene.

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.