Hub : Genes

Tmtc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000004585	0.12	0.06	6.6e-09	0.08	0.08	0.08	0.08	6.3e-09	9.3e-09	6.1e-09	2.5e-09
2	BLA	gene expression	ENSRNOG00000004585	0.16	0.07	3.6e-06	0.07	0.1	0.1	0.1	9.1e-05	3.1e-06	6.1e-06	4.2e-06
3	Brain	gene expression	ENSRNOG00000004585	0.14	0.06	1.1e-09	0.1	0.12	0.12	0.12	9.4e-10	3.2e-11	3.1e-11	7.6e-11
4	Liver	gene expression	ENSRNOG00000004585	0.05	0.03	4.7e-04	0.04	0.03	0.03	0.03	4.3e-05	7.3e-04	2.3e-04	9.7e-05
5	NAcc	gene expression	ENSRNOG00000004585	0.14	0.06	2.2e-07	0.08	0.08	0.07	0.07	2.1e-06	1.2e-06	6.5e-06	3.9e-06
6	NAcc	intron excision ratio	chr7:40543989:40545542	0.09	0.05	7.0e-05	0.05	0.06	0.03	0.06	8.4e-05	2.0e-05	2.0e-03	1.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	1.3	4.3	11.3	0.4	-2.0	-1.1	-0.6	-3.4	3.0
BMI without tail	1.0	2.2	4.0	1.8	-0.9	0.3	1.0	-2.0	2.0
Body weight	0.2	0.8	2.0	0.8	-0.5	0.2	-0.1	-1.4	1.3
Epididymis fat weight	0.1	0.3	1.9	-0.0	-0.3	0.1	1.4	0.2	-0.1
Glucose	0.3	0.4	1.7	0.4	-0.5	0.1	1.3	-0.1	0.4
Heart weight	0.7	1.0	3.4	1.8	0.7	1.3	-0.8	-0.2	-0.0
Left kidney weight	0.8	2.2	4.1	2.0	1.2	2.0	-1.3	0.8	-1.1
Right kidney weight	0.6	1.6	2.5	1.0	1.3	1.6	-0.3	1.6	-1.5
Tail length	1.3	3.9	5.9	2.1	2.0	2.4	1.8	2.1	-1.3
Length with tail	0.4	1.4	2.6	0.5	1.3	1.3	1.2	1.6	-1.0
Length without tail	0.2	0.4	1.7	-1.3	-0.1	-0.6	-0.3	0.2	-0.0
Liver weight, left	1.9	3.1	6.4	0.6	-2.0	-0.5	1.6	-2.2	2.5
Liver weight, right	0.5	0.8	2.6	1.6	0.0	0.8	-0.3	-1.1	0.7
Parametrial fat weight	0.3	0.6	1.4	1.0	-0.2	0.6	0.6	-0.7	1.2
Retroperitoneal fat weight	0.2	0.6	2.1	1.4	0.2	1.0	-0.3	-0.3	0.0
Intraocular pressure	0.4	0.5	1.1	-0.5	0.1	-0.2	1.1	1.1	-0.6
Extensor digitorum longus weight	0.1	0.6	2.3	-0.3	-0.2	-0.6	-1.5	-0.8	0.4
Soleus weight	0.8	2.3	3.7	-1.0	-1.6	-1.6	0.5	-1.9	1.9
Tibialis anterior weight	0.1	0.4	1.1	-0.1	0.6	0.1	-1.0	0.5	-0.8
Tibia length	1.4	3.9	5.4	-2.1	-2.1	-2.2	2.3	-1.3	1.6
Number of licking bursts	0.4	0.5	1.0	0.6	0.6	1.0	0.7	0.6	-0.3
Food consumed during 24 hour testing period	0.1	0.1	0.3	0.1	0.2	-0.3	-0.6	-0.5	0.4
Times rat made contact with spout	0.9	1.0	2.8	0.2	-0.4	-0.4	-1.7	-1.4	1.1
Mean time between licks in bursts	1.6	2.2	4.5	2.1	1.7	2.1	0.5	0.9	-0.6
Mean num. licks in bursts	0.7	0.9	2.5	-0.1	-0.6	-0.8	-1.6	-1.1	0.7
Std. dev. time between licks in bursts	1.3	1.6	2.9	0.1	1.5	1.0	-0.8	1.7	-1.6
Water consumed over 24 hours	0.5	0.5	1.2	1.0	0.7	0.5	-1.1	-0.5	0.3
Indifference point 0 sec	0.6	1.0	3.3	-1.8	-0.6	-1.2	0.4	0.4	-0.6
Indifference point AUC	0.8	0.9	3.8	-2.0	-0.6	-1.1	0.2	0.5	-0.2
Indifference point function ln k	0.8	1.2	4.3	2.1	0.8	1.4	0.1	-0.2	0.2
Indifference point function log k	0.8	1.2	4.3	2.1	0.8	1.4	0.1	-0.2	0.2
Delay discounting total patch changes 0 sec	0.5	0.8	2.7	-1.7	-0.4	-0.9	0.5	0.7	-0.7
Delay discounting total patch changes 12 sec	1.1	1.5	4.2	-2.0	-0.5	-1.0	1.4	1.0	-0.8
Delay discounting total patch changes 18 sec	0.9	1.2	3.6	-1.9	0.0	-0.7	-0.3	1.3	-1.2
Delay discounting total patch changes 24 sec	0.5	0.6	2.1	-1.0	-0.5	-0.5	1.4	0.0	0.3
Delay discounting total patch changes 6 sec	0.6	0.9	3.3	-1.8	-0.3	-1.0	1.0	0.5	-0.4
Delay discounting time to switch 0 sec	0.0	0.0	0.1	0.1	-0.2	-0.3	0.1	-0.3	0.2
Delay discounting water rate 0 sec	0.3	0.5	0.8	0.0	0.9	0.6	0.7	0.9	-0.7
Delay discounting water rate 12 sec	0.7	1.0	3.2	1.8	0.0	1.0	0.6	-0.9	0.9
Delay discounting water rate 18 sec	0.6	0.8	2.9	1.7	0.5	1.2	-0.1	-0.2	0.1
Delay discounting water rate 24 sec	1.7	2.3	6.2	2.5	0.7	2.1	1.8	0.1	-0.1
Delay discounting water rate 6 sec	1.2	1.7	6.0	2.4	1.1	1.6	0.0	-0.4	0.5
Locomotor activity	0.2	0.3	0.6	0.8	0.7	0.8	-0.2	0.4	-0.3
Locomotor testing distance	0.1	0.2	0.4	0.7	0.6	0.7	0.2	0.3	-0.2
Locomotor testing rearing	0.3	0.5	1.0	0.1	1.0	0.5	0.1	1.0	-1.0
Light reinforcement 1	0.7	1.3	2.1	-0.8	-1.3	-1.1	-0.8	-1.5	1.1
Light reinforcement 2	0.4	0.5	2.0	-0.1	-0.3	-0.4	-1.4	-0.7	0.5
Reaction time number correct	2.1	3.0	6.2	0.1	-2.1	-1.1	0.0	-2.5	2.5
Reaction time mean minus median	0.7	0.9	4.0	-0.5	-0.3	-0.0	2.0	0.9	-0.4
Reaction time mean minus median AUC	1.3	1.7	5.6	-1.2	-1.3	-0.9	2.4	0.1	0.4
Reaction time num false alarms	1.1	1.5	3.9	0.8	1.2	0.7	-2.0	0.8	-1.3
Reaction time num false alarms AUC	1.1	1.6	3.4	0.6	1.2	0.7	-1.8	1.1	-1.6
Reaction time trials correct on left	2.1	3.0	6.2	0.1	-2.1	-1.1	0.0	-2.5	2.5
Reaction time trials on left	1.9	2.7	5.5	0.0	-2.0	-1.1	-0.1	-2.3	2.3
Reaction time mean	7.1	9.8	23.1	0.3	3.1	2.2	1.0	4.8	-4.5
Reaction time mean AUC	6.3	8.4	19.6	0.3	2.9	2.0	0.8	4.4	-4.2
Median of all reaction times	10.3	13.9	30.3	0.8	4.0	2.9	0.5	5.5	-5.3
Reaction time omissions	0.7	1.0	2.8	-1.1	0.2	-0.1	0.0	1.7	-1.3
Reaction time false alarm rate	2.1	2.9	6.2	0.3	2.0	1.0	-1.6	2.0	-2.5
Reaction time premature initiation rate	4.4	5.9	9.9	3.0	3.1	3.1	-0.5	1.9	-1.8
Reaction time premature initiations	1.7	2.4	7.1	2.7	1.5	2.1	-0.5	0.2	-0.2
Std. dev. reaction times	2.4	3.3	7.8	0.1	1.4	1.2	1.6	2.8	-2.4
Reaction time trials completed	1.9	2.7	5.5	0.0	-2.0	-1.1	-0.1	-2.3	2.3
Reaction time trials AUC	1.7	2.4	5.3	0.1	-1.8	-1.0	-0.3	-2.3	2.2
Social response proportion	2.0	2.2	6.2	0.5	1.5	0.8	-2.5	1.2	-1.5
Social responses	0.4	0.6	3.2	0.3	0.4	-0.2	-1.8	-0.2	0.1
Social time	0.2	0.2	0.4	0.1	0.3	0.2	0.6	0.6	-0.7
Conditioned locomotion	0.6	0.7	1.5	-1.2	-1.0	-0.9	-0.7	-0.3	0.3
Cocaine response after cond. corrected	0.5	0.5	2.2	-0.2	-0.9	-0.1	1.5	-0.1	0.4
Cocaine response after cond. not corrected	0.5	0.6	3.1	0.1	-0.6	0.2	1.8	0.2	-0.2
Cocaine response before conditioning	0.6	0.8	1.6	0.6	1.1	0.7	0.5	0.9	-1.3
Saline control response	0.3	0.4	0.6	0.5	0.5	0.8	-0.8	0.3	-0.7
Condit. Reinf. active minus inactive responses	1.1	1.4	4.2	2.1	1.3	1.6	-0.1	0.0	-0.1
Condit. Reinf. active-inactive response ratio	1.5	1.5	4.5	2.1	1.3	1.7	-0.3	0.1	-0.4
Condit. Reinf. active responses	0.3	0.4	1.3	1.1	0.7	0.8	-0.1	-0.3	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.5	-0.1	-0.3	0.5	0.0	0.0
Condit. Reinf. lever presses	0.1	0.1	0.3	0.3	0.5	0.3	0.1	0.3	-0.2
Condit. Reinf. lever reinforcers received	0.3	0.4	1.4	1.2	0.6	0.8	0.2	-0.3	0.2
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.0	-0.1	-0.3	-0.3	-0.6	0.2
Pavlov. Cond. magazine entry latency	0.7	0.8	1.7	1.0	0.3	1.3	0.5	1.1	-0.8
Pavlov. Cond. change in total contacts	0.7	1.0	1.8	1.1	0.8	1.4	0.6	1.1	-0.7
Pavlov. Cond. index score	0.5	0.7	1.4	0.7	0.6	1.1	0.2	1.2	-0.9
Pavlov. Cond. latency score	0.6	0.8	1.6	1.0	0.6	1.3	0.0	1.1	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.2	0.1	0.4	-0.1	0.5	-0.2
Pavlov. Cond. magazine entry number	1.5	1.8	4.0	-0.9	-0.9	-1.6	-1.0	-2.0	1.4
Pavlov. Cond. intertrial magazine entries	0.7	0.9	2.2	-1.3	-0.8	-1.5	-0.3	-0.8	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.0	0.8	0.7	1.2	0.2	1.4	-1.0
Pavlov. Cond. response bias	0.2	0.3	0.6	0.4	0.1	0.7	0.8	0.7	-0.2
Conditioned reinforcement - actives	0.6	0.6	1.2	-0.8	-0.6	-0.9	0.6	-0.7	1.1
Conditioned reinforcement - inactives	0.3	0.3	1.2	-1.1	0.2	-0.7	0.2	0.5	-0.1
Conditioned locomotion	0.1	0.2	0.7	-0.2	0.3	-0.2	0.9	0.2	0.1
Intermittent access intake day 1-15 change	0.4	0.4	1.0	-0.2	-0.7	-0.3	1.0	-0.4	0.6
Intermittent access intake escalation	0.4	0.4	1.5	-0.2	-0.6	-0.2	1.2	-0.2	0.4
Intermittent access intake escalation 2	0.5	0.5	1.0	0.3	-0.5	-0.2	0.7	-1.0	0.9
Intermitt. access day 1 inactive lever presses	0.3	0.4	0.9	-1.0	-0.7	-0.8	0.2	0.1	-0.1
Intermitt. access day 15 inactive lever presses	0.8	0.9	1.5	-0.8	-1.0	-1.0	-1.2	-1.0	0.6
Intermitt. access escalation Index	0.4	0.4	0.8	0.9	0.4	0.5	-0.4	-0.8	0.5
Intermittent access day 1 total infusions	0.3	0.4	1.2	-0.7	-0.1	-0.4	1.1	0.7	-0.1
Intermittent access day 15 total infusions	0.6	0.7	3.0	-0.8	-0.4	-0.5	1.7	0.4	0.1
Intermittent access terminal intake (last 3 days)	0.8	0.9	1.5	-1.0	-0.9	-1.0	1.2	-0.4	0.8
Intermittent access total infusions	0.6	0.7	1.7	-1.0	-0.6	-0.8	1.3	0.2	0.5
Intermittent access day 1 locomotion	1.1	1.1	2.6	-0.6	0.9	0.1	1.3	1.6	-1.1
Intermittent access day 15 total locomotion	2.1	2.2	5.8	-0.2	1.5	0.7	0.9	2.4	-2.0
Intermittent access total locomotion	0.9	1.0	2.8	-0.4	0.8	0.3	1.1	1.7	-1.2
Intermittent access standard deviation	1.0	1.0	1.7	-0.6	-1.3	-0.9	0.9	-1.0	1.2
Cocaine induced anxiety	2.6	3.0	7.5	-2.7	-1.8	-2.4	0.1	-0.9	0.8
Post-drug Anxiety	3.1	3.4	5.6	-2.1	-2.4	-2.2	-0.1	-1.8	1.6
Baseline Anxiety	1.7	1.8	5.3	2.3	0.9	2.0	-0.1	0.5	-0.5
Lifetime Intake	0.8	0.9	2.3	-1.1	-0.8	-0.9	1.5	0.1	0.6
Incentive Sensitization - Responses	0.8	0.8	1.9	-1.4	-0.5	-1.4	0.3	-0.4	0.6
Incentive Sensitization - Breakpoint	0.6	0.6	1.6	-1.3	-0.5	-1.2	0.4	-0.3	0.4
Progressive ratio test 1 active lever presses	0.4	0.4	1.1	0.1	0.6	0.4	0.5	1.0	-0.5
Progressive ratio test 1 breakpoint	0.3	0.3	0.9	0.2	0.5	0.4	0.4	0.9	-0.4
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.8	-0.1	-0.5	-0.2	0.9	0.1	0.3
Progressive ratio test 2 active lever presses	0.3	0.4	0.8	-0.9	-0.3	-0.9	0.3	-0.1	0.5
Progressive ratio test 2 breakpoint	0.3	0.3	0.8	-0.9	-0.1	-0.8	0.4	0.1	0.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.5	-0.7	0.0	-0.5	-0.3	0.3	-0.0
Total sessions with >9 infusions	0.7	0.7	1.2	-1.0	-0.8	-1.0	1.1	-0.4	0.7
Short access day 1 total inactive lever presses	0.8	0.9	2.5	-0.9	0.3	-0.2	0.9	1.6	-1.1
Short access day 10 total inactive lever presses	1.0	1.1	4.7	0.9	-0.1	0.3	-2.2	-1.0	0.4
Short access day 1 total infusions	0.4	0.4	1.4	-0.2	-0.8	-0.3	1.2	-0.2	0.6
Short access day 10 total infusions	0.5	0.5	2.1	-0.5	0.1	-0.1	1.5	0.9	-0.3
Short access total infusions	0.4	0.4	0.7	-0.7	-0.7	-0.6	0.8	-0.0	0.5
Short access day 1 locomotion	0.9	0.9	4.8	0.5	-0.3	0.5	2.2	0.0	0.4
Short access day 10 total locomotion	1.2	1.3	2.3	0.3	0.9	0.9	1.5	1.4	-1.3
Short access total locomotion	0.2	0.2	1.0	0.1	0.0	0.2	1.0	0.2	-0.1
Compulsive drug intake	0.2	0.2	0.5	-0.3	-0.3	-0.3	-0.7	-0.4	0.1
One hour access (0.3 mA shock)	0.8	1.0	2.1	-1.5	0.2	-0.8	1.5	0.8	-0.4
One hour access (shock baseline)	0.8	1.0	3.3	-1.2	-0.2	-0.8	1.8	0.5	0.0
Number of responses in last shaping day	0.5	0.5	1.1	0.8	0.9	0.7	-1.1	0.1	-0.2
Context. condit. distance diff. score	1.9	2.4	6.5	-0.1	1.5	0.8	0.8	2.5	-2.0
Locomotion velocity, session 1	1.0	1.1	2.9	1.7	0.4	0.9	-0.6	-1.1	0.8
Locomotion distance, session 1	1.2	1.5	2.9	1.7	-0.3	0.7	0.4	-1.7	1.6
Locomotion velocity, session 2	1.2	1.4	2.4	0.7	-1.0	-0.3	1.5	-1.5	1.6
Locomotion distance, session 2	1.9	2.7	6.2	1.3	-1.2	-0.1	0.8	-2.5	2.5
Locomotion velocity, session 3	1.4	1.6	2.3	1.5	1.5	1.5	0.2	1.2	-1.2
Locomotion distance, session 3	2.7	3.0	4.3	1.8	1.9	2.1	1.2	1.7	-1.4
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	0.3	0.1	0.1	-0.6	0.3	-0.1
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.2	-0.6	-0.6	-0.8	-0.7	0.6
Locomotion velocity, session 7	1.2	1.3	1.8	1.1	1.1	1.4	0.7	1.2	-1.2
Locomotion distance, session 7	0.9	1.1	2.1	0.6	0.8	0.9	1.4	1.3	-1.2
Stereotopy head waving bouts, day 7	0.7	0.8	2.1	1.4	0.3	1.5	0.4	0.5	-0.2
Stereotopy head waving duration, day 7	0.8	1.0	2.1	1.2	0.7	1.4	0.6	1.0	-0.8
Locomotion velocity, session 8	0.1	0.2	0.5	0.1	0.3	-0.2	-0.7	-0.5	0.3
Locomotion distance, session 8	0.6	0.9	1.3	0.9	1.1	1.1	0.6	1.1	-0.8
Degree of sensitization distance	0.6	0.6	1.6	-1.3	-0.9	-1.1	0.0	-0.1	-0.2
Degree of sensitization stereotypy	0.6	0.6	1.5	1.2	0.1	1.2	1.0	0.2	0.1
Condit. Reinf. active minus inactive responses	0.3	0.3	1.3	-0.4	0.3	-0.2	-1.1	0.0	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.5	0.6	-0.1	-0.6	0.4	-0.3
Condit. Reinf. active responses	0.1	0.1	0.8	-0.1	0.1	-0.1	-0.9	-0.0	0.2
Condit. Reinf. inactive responses	0.4	0.5	2.0	1.4	0.2	1.0	-0.2	0.1	-0.1
Incentive salience index mean	0.6	0.8	1.7	-0.8	-0.4	-0.9	-1.3	-0.8	0.8
Condit. Reinf. lever presses	1.6	2.1	3.6	-1.0	-1.6	-1.5	-0.9	-1.9	1.7
Time in familiar zone, hab. session 1	0.7	0.6	3.2	0.3	0.6	0.0	-1.8	-0.4	-0.1
Time in novel zone, hab. session 1	0.6	0.6	2.4	-0.4	-0.3	0.0	1.5	0.9	-0.4
Total zone transitions, hab. session 1	0.7	1.0	2.1	1.4	0.3	0.5	-0.6	-1.4	1.0
Total locomotion distance, hab. session 1	0.7	0.9	1.7	1.1	0.4	0.5	-1.0	-1.3	1.1
Locomotion velocity, hab. session 1	0.7	1.1	2.4	1.2	0.0	0.5	-0.8	-1.5	1.3
Time in familiar zone, hab. session 2	0.8	0.8	2.6	1.6	0.8	1.2	-0.2	0.0	-0.2
Time in novel zone, hab. session 2	0.9	0.9	2.3	-1.5	-0.9	-1.4	0.4	-0.3	0.5
Total zone transitions, hab. session 2	0.7	0.9	2.6	0.6	-0.2	-0.1	0.3	-1.6	1.4
Total locomotion distance, hab. session 2	0.5	0.6	1.6	0.6	0.3	0.2	-0.4	-1.3	1.2
Locomotion velocity, hab. session 2	0.4	0.6	1.5	0.5	0.2	0.2	-0.3	-1.2	1.2
Novel to familiar place preference ratio	0.5	0.5	1.8	-1.3	-0.7	-0.9	0.0	-0.1	0.3
Novelty place preference	0.3	0.3	1.3	-1.2	-0.4	-0.7	-0.2	0.1	0.0
Time in novel zone, NPP test	0.2	0.2	0.9	-1.0	-0.2	-0.5	-0.0	0.2	-0.1
Total zone transitions, NPP test	0.5	0.7	2.4	0.4	-0.3	-0.3	-0.1	-1.5	1.2
Total locomotion distance, NPP test	0.9	1.3	3.6	0.9	0.0	0.1	-0.5	-1.9	1.7
Locomotion velocity, NPP test	0.7	1.1	2.9	0.8	0.1	0.0	-0.8	-1.7	1.4
Pavlov. Cond. lever latency	0.1	0.1	0.4	-0.2	-0.0	-0.3	0.6	-0.1	0.2
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	0.5	0.4	0.7	0.3	1.0	-1.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.1	0.2	0.0	-0.2	0.4	-0.5
Pavlov. Cond. index score	0.6	0.7	1.5	1.1	0.7	1.2	-0.0	0.8	-0.8
Pavlov. Cond. latency score	0.4	0.5	0.9	0.8	0.5	0.9	-0.3	0.6	-0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.4	-0.1	0.3	-0.5	-0.2	-0.0
Pavlov. Cond. magazine entry number	1.3	1.7	2.6	-1.3	-1.1	-1.6	-0.1	-1.5	1.5
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.5	-0.5	1.0	-0.0	-1.2	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.0	0.9	0.4	1.0	0.3	0.5	-0.5
Pavlov. Cond. response bias	0.2	0.3	0.7	0.8	0.1	0.8	0.3	0.5	-0.4
Bone: apparent density	0.2	0.4	0.7	-0.1	0.6	0.2	-0.5	0.8	-0.9
Bone surface	0.4	0.6	1.2	-1.0	-1.0	-0.7	1.1	0.0	0.4
Bone volume	0.1	0.1	0.3	-0.5	-0.4	-0.4	0.3	0.3	-0.1
Bone: connectivity density	0.2	0.3	0.6	-0.4	0.2	0.0	0.6	0.8	-0.7
Bone: cortical apparent density	3.1	4.1	6.5	1.8	2.1	2.5	1.0	2.1	-2.2
Bone: cortical area	0.6	0.9	4.2	0.8	0.3	0.6	2.0	0.5	-0.0
Bone: cortical porosity	0.9	1.0	2.1	-0.9	-0.6	-1.5	-0.9	-1.1	0.8
Bone: cortical porosity	1.0	1.1	2.1	-0.9	-0.5	-1.5	-1.3	-1.1	0.6
Bone: cortical thickness	1.0	1.6	2.9	1.0	0.9	1.1	1.7	1.5	-1.1
Bone: cortical thickness	2.7	3.1	6.0	1.5	2.4	1.7	0.6	1.9	-1.9
Bone: cortical tissue density	3.0	3.9	6.3	1.8	2.1	2.5	0.9	2.1	-2.2
Bone: elastic displacement	0.7	0.8	2.1	0.4	1.5	0.5	-0.8	0.7	-0.9
Bone: elastic work	0.4	0.6	1.4	1.0	1.2	0.9	-0.0	0.2	-0.3
Bone: endosteal estimation	0.4	0.8	1.6	-0.6	-0.8	-0.9	-0.1	-1.2	1.3
Bone: endosteal perimeter	0.2	0.4	1.0	-0.5	-0.5	-0.5	0.7	-0.5	1.0
Bone: final force	0.4	0.7	2.5	-0.8	0.2	-0.3	1.6	0.9	-0.3
Bone: final moment	0.3	0.6	2.4	-0.6	0.0	-0.2	1.6	0.7	-0.2
Bone: marrow area	0.3	0.7	1.5	-0.6	-0.7	-0.8	0.0	-1.1	1.2
Bone: maximum diameter	0.5	0.9	1.9	0.1	-1.0	-0.4	1.3	-0.9	1.4
Bone: maximum force	0.3	0.6	2.8	-0.4	0.0	-0.1	1.7	0.6	-0.1
Bone: maximum moment	0.3	0.5	2.9	-0.1	-0.1	0.0	1.7	0.4	0.1
Bone: minimum diameter	0.5	0.9	4.5	0.3	-0.2	0.1	2.1	-0.1	0.7
Bone: periosteal estimation	0.2	0.4	1.2	0.3	-0.3	-0.1	1.1	-0.5	0.8
Bone: periosteal perimeter	0.2	0.4	1.8	0.1	-0.4	-0.1	1.3	-0.1	0.6
Bone: post-yield work	0.4	0.6	1.5	-0.1	-1.2	-0.3	0.7	-0.6	1.0
Bone: stiffness	0.4	0.6	3.0	0.6	0.1	0.6	1.7	0.3	0.3
Bone: tissue strength	0.3	0.3	0.6	-0.1	-0.3	-0.3	-0.8	-0.7	0.5
Bone: trabecular number	0.5	0.8	2.2	-0.6	0.5	0.0	0.6	1.5	-1.3
Bone: trabecular spacing	2.1	2.7	5.3	-0.5	-2.0	-1.3	1.2	-1.9	2.3
Bone: trabecular thickness	1.8	2.1	3.6	1.9	1.6	1.6	-1.7	0.5	-1.0
Bone: trabecular tissue density	0.8	1.1	2.8	1.4	0.6	0.6	-1.7	-1.0	0.5
Breakpoint value in progressive ratio session	2.6	3.0	4.0	2.0	1.7	2.0	-1.7	1.4	-1.5
Distance traveled before self-admin	0.6	0.6	1.3	0.6	0.3	0.8	1.1	0.9	-0.8
Distance traveled after self-admin	0.1	0.1	0.2	-0.1	-0.4	-0.2	0.2	-0.1	0.1
Delta time in closed arm before/after self-admin	1.2	1.2	3.4	-1.2	0.1	-0.6	-1.8	0.7	-1.1
Delta time in open arm before/after self-admin	0.4	0.4	0.9	0.2	0.4	0.6	0.1	0.8	-0.9
Diff in mean of infusions in LGA sessions	4.0	4.5	6.3	2.5	2.5	2.4	-2.0	1.6	-1.7
Extinction: sum of active levers before priming	1.1	1.1	3.5	-1.9	-0.7	-1.4	-0.7	-0.0	0.0
Active lever presses in extinction session 6	1.7	1.6	2.9	-0.0	1.7	0.6	-1.2	1.6	-1.6
Delta distance traveled before/after self-admin	0.1	0.1	0.4	-0.2	0.0	-0.2	-0.7	-0.1	-0.1
Delta ambulatory time before/after self-admin	1.1	1.2	2.2	-1.3	-1.1	-1.5	-0.2	-1.1	1.1
Time in closed arm before self-admin	0.6	0.7	2.6	0.8	0.3	0.8	1.6	0.4	-0.0
Time in closed arm after self-admin	0.2	0.2	0.4	-0.1	0.3	0.2	-0.7	0.5	-0.6
Time in open arm before self-admin	0.3	0.3	0.7	-0.5	-0.1	-0.7	-0.9	-0.3	0.3
Time in open arm after self-admin	0.2	0.2	0.4	-0.4	0.4	-0.0	-0.3	0.6	-0.6
Sum of active levers in priming session hrs 5-6	2.7	2.7	4.5	2.1	1.8	2.1	-1.3	1.1	-1.1
Time to tail flick, vehicle, before self-admin	1.8	1.8	2.3	1.3	1.5	1.5	-1.1	1.2	-1.5
Time to tail flick, vehicle, after self-admin	0.6	0.7	2.0	1.4	-0.2	1.1	1.0	-0.0	-0.0
Time to tail flick, test, before self-admin	1.8	1.7	5.2	2.3	0.2	1.3	-0.3	-1.3	1.3
Time to tail flick, test, after self-admin	1.2	1.2	3.6	1.9	1.0	1.4	0.7	-0.4	0.4
Delta time to tail flick, vehicle, before/after SA	1.2	1.1	2.1	-0.7	-1.4	-0.9	1.4	-0.7	1.0
Delta time to tail flick, test, before/after SA	0.3	0.2	1.3	-0.3	0.0	-0.1	1.1	0.1	-0.1
Ambulatory time before self-admin	0.9	1.0	2.3	0.7	0.4	1.0	1.5	0.9	-0.9
Ambulatory time after self-admin	0.0	0.0	0.1	-0.0	0.0	0.0	0.2	0.3	-0.3
Total heroin consumption	0.2	0.2	1.1	0.4	0.2	0.2	-1.0	0.2	-0.1
Area under the delay curve	1.0	1.0	2.0	1.2	0.5	1.4	1.0	1.1	-0.7
Delay disc. indifference point, 0s delay	0.7	0.8	2.1	-0.9	-1.5	-0.9	0.7	-0.1	0.6
Delay disc. indifference point, 16s delay	2.0	2.0	3.8	1.8	0.7	1.9	1.6	1.2	-0.6
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.0	-0.1	0.2	-0.2	0.4	-0.5
Delay disc. indifference point, 24s delay	1.3	1.3	2.3	1.5	0.8	1.5	1.4	0.8	-0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	-0.7	-0.4	-0.4	-0.1	0.2	-0.2
Delay disc. indifference point, 8s delay	0.8	0.9	1.9	1.0	0.2	1.2	1.4	0.8	-0.4
Delay discount exponential model param	1.1	1.2	2.5	-1.4	-0.7	-1.6	-0.8	-1.0	0.7
Delay discount hyperbolic model param	0.9	0.9	1.9	-1.1	-0.5	-1.4	-0.7	-1.0	0.7
Fecal boli incidents, locomotor time 1	0.6	0.6	1.4	0.0	0.8	0.5	-0.7	0.9	-1.2
Change in fecal boli incidents, locomotor task	1.2	1.1	1.9	1.0	1.4	1.2	-0.3	1.2	-0.8
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	-0.4	-0.3	-0.5	0.4	-0.5	0.5
Bouts of movement, locomotor time 1	1.6	1.8	3.5	1.4	1.4	1.9	-0.6	1.3	-1.1
Total resting periods, locomotor time 1	0.6	0.7	1.4	0.9	0.7	1.2	-0.7	0.8	-0.7
Rest time, locomotor task time 1	0.2	0.2	0.8	-0.2	-0.2	-0.2	-0.9	-0.1	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.7	0.1	0.1	-0.1	0.9	-0.2	0.2
Vertical activity count, locomotor time 1	0.2	0.2	0.4	0.3	0.6	0.4	0.4	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	-0.1	-0.4	-0.2	-0.6	-0.3	0.6
Bouts of movement, locomotor time 2	0.1	0.2	0.6	0.7	-0.1	0.4	-0.2	-0.3	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.4	-0.2	0.2	-0.2	-0.3	0.4
Rest time, locomotor task time 2	0.4	0.5	1.6	-0.3	0.3	0.1	-1.3	0.7	-0.8
Distance moved, locomotor task time 2	0.9	1.0	2.1	0.4	-0.9	-0.2	1.4	-1.1	1.3
Vertical activity count, locomotor time 2	0.5	0.6	2.4	0.7	0.4	0.5	1.6	0.1	0.2
Weight adjusted by age	0.3	0.3	0.5	-0.3	-0.7	-0.4	0.7	-0.7	0.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.4	0.5	0.6	0.5	1.2	0.3	0.1
Locomotion in novel chamber	3.2	3.9	6.2	1.4	2.1	2.2	1.8	2.5	-1.7
Locomotion in novel chamber post-restriction	0.2	0.2	0.6	-0.1	0.8	0.1	0.1	0.6	-0.4
Progressive ratio	1.6	1.8	4.9	-0.4	0.7	0.5	2.2	1.9	-1.3
Food seeking constrained by brief footshock	1.4	1.8	3.5	1.4	1.1	1.6	-1.9	0.6	-1.0
Seeking ratio, punishment vs. effort	1.6	2.0	6.1	1.8	0.4	1.2	-2.5	-0.9	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.4	0.3	0.1	0.3	0.6	0.3	-0.4
Run reversals in cocaine runway, males	0.4	0.4	1.8	-0.2	0.5	-0.0	-1.3	0.3	-0.5
Latency to leave start box in cocaine runway	0.9	1.0	2.4	-0.3	-1.4	-0.4	1.5	-0.4	1.1
Latency to leave start box in cocaine runway, F	1.1	1.2	2.1	-1.4	-1.5	-1.4	0.0	-0.7	0.9
Latency to leave start box in cocaine runway, M	2.4	2.3	5.7	1.6	0.3	1.8	2.4	1.3	-0.6
Cd content in liver	0.4	0.4	1.1	-1.0	-0.4	-1.0	0.0	-0.4	0.4
Co content in liver	0.1	0.1	0.2	0.4	-0.2	0.1	0.2	-0.2	0.3
Cu content in liver	0.6	0.8	1.5	1.2	-0.2	0.6	-0.2	-1.1	1.2
Fe content in liver	0.9	1.1	2.0	-0.8	-0.6	-1.4	-0.4	-1.3	1.3
K content in liver	2.0	2.0	6.8	1.0	-0.4	0.2	-2.6	-1.6	1.3
Mg content in liver	0.9	1.0	1.7	-0.2	-1.0	-0.6	-1.1	-1.3	1.3
Mn content in liver	0.1	0.1	0.3	0.1	-0.3	-0.2	-0.2	-0.6	0.5
Na content in liver	1.7	1.8	3.8	-0.2	-1.4	-0.9	-0.6	-1.8	1.9
Rb content in liver	0.7	0.8	2.1	-0.7	-1.5	-0.9	0.4	-0.7	1.0
Se content in liver	0.3	0.4	0.9	-0.2	-0.5	-0.4	1.0	-0.5	0.9
Sr content in liver	0.1	0.1	0.1	0.3	-0.1	0.1	0.3	-0.2	0.2
Zn content in liver	1.0	1.2	2.9	-0.1	-0.8	-0.8	-0.7	-1.7	1.5