Hub : Genes

Sec14l4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000004555 0.15 0.06 0.0e+00 0.16 0.16 0.16 0.16 1.2e-17 1.2e-17 3.1e-17 7.3e-18
2 Adipose isoform ratio ENSRNOT00000006053 0.1 0.05 3.0e-10 0.08 0.08 0.08 0.07 2.0e-09 1.7e-09 3.4e-09 1.0e-08
3 Adipose isoform ratio ENSRNOT00000113444 0.17 0.07 0.0e+00 0.13 0.13 0.13 0.12 2.6e-14 5.6e-14 5.5e-14 8.8e-14
4 BLA gene expression ENSRNOG00000004555 0.15 0.07 5.7e-07 0.15 0.11 0.12 0.13 1.5e-08 2.0e-06 1.1e-06 3.0e-07
5 Brain gene expression ENSRNOG00000004555 0.22 0.09 0.0e+00 0.2 0.2 0.2 0.2 4.1e-18 7.4e-18 3.8e-18 4.0e-18
6 Brain isoform ratio ENSRNOT00000113444 0.05 0.03 7.0e-05 0.03 0.04 0.04 0.04 5.9e-04 1.1e-04 1.1e-04 1.4e-04
7 Eye alternative polyA ENSRNOT00000113444 0.56 0.17 6.3e-04 0.19 0.07 0.09 0.17 6.7e-04 2.8e-02 1.6e-02 1.4e-03
8 Eye gene expression ENSRNOG00000004555 0.7 0.11 1.1e-07 0.28 0.3 0.28 0.29 3.4e-05 1.5e-05 3.2e-05 2.4e-05
9 Eye isoform ratio ENSRNOT00000006116 0.43 0.15 9.8e-04 0.11 0.06 0.05 0.12 9.1e-03 4.2e-02 6.8e-02 5.8e-03
10 Eye isoform ratio ENSRNOT00000113444 0.65 0.13 3.8e-06 0.24 0.27 0.27 0.29 1.4e-04 5.2e-05 4.7e-05 2.1e-05
11 IL gene expression ENSRNOG00000004555 0.17 0.09 1.7e-03 0.09 0.09 0.08 0.11 3.9e-03 3.4e-03 7.2e-03 1.3e-03
12 NAcc gene expression ENSRNOG00000004555 0.56 0.15 0.0e+00 0.44 0.42 0.43 0.43 1.5e-35 5.6e-34 4.0e-35 1.3e-34
13 NAcc isoform ratio ENSRNOT00000113444 0.04 0.03 5.2e-03 0.03 0.03 0.02 0.02 3.9e-03 4.6e-03 6.9e-03 1.7e-02
14 OFC gene expression ENSRNOG00000004555 0.29 0.14 2.6e-04 0.12 0.14 0.05 0.14 8.1e-04 3.7e-04 2.4e-02 3.7e-04
15 PL gene expression ENSRNOG00000004555 0.25 0.09 4.7e-13 0.18 0.16 0.17 0.18 1.6e-13 1.6e-12 1.1e-12 9.8e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
BMI with tail0.41.43.70.91.0-0.91.91.2-1.40.9-0.6-0.31.41.71.1-0.31.61.2
BMI without tail0.40.72.50.30.2-0.20.91.0-0.80.2-0.20.30.31.41.1-1.01.61.2
Body weight2.08.411.82.62.5-2.43.13.3-3.12.7-2.3-1.92.73.33.2-3.23.43.2
Epididymis fat weight0.51.13.7-0.50.1-0.20.11.1-0.9-0.7-0.20.8-0.31.71.5-1.11.91.5
Glucose7.711.728.84.84.9-4.93.91.0-2.24.7-3.1-5.44.7-0.4-0.1-0.2-0.9-0.2
Heart weight0.40.61.0-0.4-0.60.6-0.7-0.80.8-0.61.00.8-0.9-0.9-0.90.1-0.8-0.9
Left kidney weight0.30.92.6-1.0-1.21.1-1.00.20.4-0.81.01.6-1.30.50.6-0.90.90.6
Right kidney weight0.61.74.8-1.3-1.31.4-0.90.6-0.1-1.60.62.2-1.51.41.3-1.51.51.1
Tail length1.13.411.41.40.9-0.81.12.3-1.61.6-1.6-1.30.91.92.4-3.42.22.4
Length with tail1.65.714.72.11.8-1.61.62.8-2.22.2-1.8-1.81.52.53.1-3.82.82.9
Length without tail1.12.33.01.71.7-1.61.41.6-1.61.6-1.1-1.51.51.31.6-1.51.41.4
Liver weight, left2.13.58.6-2.9-2.52.7-2.3-1.11.5-2.31.32.5-2.5-0.5-0.50.6-0.4-0.4
Liver weight, right3.45.611.5-3.1-3.22.7-2.6-1.62.2-2.92.73.4-3.0-1.0-1.41.7-0.6-1.1
Parametrial fat weight0.71.42.91.71.6-1.71.6-0.1-0.51.0-1.0-1.61.7-0.4-0.50.3-0.9-0.8
Retroperitoneal fat weight0.10.20.90.2-0.0-0.20.3-0.50.2-0.90.40.5-0.2-0.3-0.70.6-0.4-0.7
Intraocular pressure0.81.12.90.3-0.2-0.5-0.0-1.21.10.01.0-0.00.1-1.6-1.51.6-1.4-1.7
Extensor digitorum longus weight2.710.813.23.43.0-3.13.33.5-3.23.6-2.8-3.33.43.03.4-3.43.23.3
Soleus weight1.02.87.60.80.9-1.20.92.0-1.32.2-0.8-1.11.01.72.2-2.82.32.1
Tibialis anterior weight1.44.76.82.32.3-2.52.22.1-2.12.6-1.8-2.32.31.82.2-1.92.02.0
Tibia length0.41.13.0-0.5-0.70.7-0.70.9-0.3-0.80.41.2-0.91.31.3-1.61.71.4
Number of licking bursts1.61.94.30.91.1-1.20.61.7-1.40.6-0.8-0.90.71.61.9-1.72.11.9
Food consumed during 24 hour testing period0.60.72.00.40.4-0.4-0.2-0.70.61.40.4-1.00.6-1.2-0.90.9-1.1-0.9
Times rat made contact with spout1.61.94.9-0.10.2-0.3-0.5-1.71.20.90.5-0.80.3-2.1-2.02.2-2.2-2.0
Mean time between licks in bursts1.11.54.2-0.3-0.20.4-0.7-1.51.20.00.6-0.3-0.4-1.9-1.61.9-2.1-1.6
Mean num. licks in bursts3.64.411.5-1.0-0.91.0-1.0-2.72.1-0.21.20.5-0.6-2.9-3.13.0-3.4-3.1
Std. dev. time between licks in bursts1.01.22.0-0.8-1.01.0-1.0-1.31.2-0.80.80.5-0.8-1.3-1.31.4-1.4-1.3
Water consumed over 24 hours1.41.64.1-0.6-0.30.2-1.2-1.61.40.41.0-0.3-0.3-2.0-1.71.8-1.8-1.7
Indifference point 0 sec0.10.10.40.00.2-0.3-0.00.4-0.30.3-0.0-0.50.30.40.4-0.50.60.4
Indifference point AUC1.01.23.4-0.4-0.50.8-0.3-1.51.10.40.3-0.50.1-1.5-1.51.7-1.8-1.3
Indifference point function ln k0.50.72.10.20.10.20.01.2-0.70.4-0.50.10.01.11.3-1.41.11.2
Indifference point function log k0.50.72.10.20.10.20.01.2-0.70.4-0.50.10.01.11.3-1.41.11.2
Delay discounting total patch changes 0 sec0.10.10.40.20.4-0.50.10.3-0.20.5-0.0-0.70.50.20.3-0.40.40.2
Delay discounting total patch changes 12 sec0.10.10.3-0.20.3-0.00.20.3-0.40.0-0.0-0.40.30.50.5-0.10.60.5
Delay discounting total patch changes 18 sec0.30.41.00.50.7-0.80.5-0.60.10.7-0.1-1.00.8-0.7-0.80.6-0.8-0.7
Delay discounting total patch changes 24 sec3.44.25.8-2.0-1.81.8-1.6-2.42.1-2.02.11.8-1.7-2.0-2.42.3-2.1-2.3
Delay discounting total patch changes 6 sec0.10.20.90.20.3-0.10.2-0.10.11.0-0.2-0.90.6-0.4-0.40.4-0.4-0.2
Delay discounting time to switch 0 sec0.71.15.1-0.6-0.4-0.2-0.50.4-0.2-2.31.01.8-1.21.00.7-0.31.50.6
Delay discounting water rate 0 sec0.71.07.50.90.8-0.40.70.2-0.02.7-0.4-1.91.3-0.6-0.10.3-0.5-0.1
Delay discounting water rate 12 sec0.20.31.30.1-0.40.30.0-0.50.71.10.3-0.40.2-0.9-0.7-0.0-0.9-0.5
Delay discounting water rate 18 sec0.60.82.2-1.1-1.41.5-1.10.20.6-0.50.91.1-1.20.20.5-0.50.70.6
Delay discounting water rate 24 sec0.40.61.7-0.1-0.50.4-0.6-0.61.11.11.30.0-0.4-1.2-0.60.8-0.7-0.6
Delay discounting water rate 6 sec0.10.21.60.3-0.40.2-0.1-0.00.51.30.5-0.40.1-0.50.0-0.3-0.1-0.0
Locomotor activity0.40.72.41.20.8-1.00.3-0.10.11.5-0.3-1.50.8-0.8-0.3-0.3-0.7-0.4
Locomotor testing distance0.60.92.71.00.5-0.70.61.1-0.71.3-0.7-1.00.80.81.0-1.61.01.0
Locomotor testing rearing1.52.45.12.11.7-1.81.61.5-1.42.3-1.5-1.91.70.81.0-1.30.81.1
Light reinforcement 10.30.61.30.60.3-0.20.90.9-0.70.4-0.3-0.30.40.91.1-1.21.00.9
Light reinforcement 20.20.20.8-0.4-0.50.4-0.40.10.2-0.10.70.3-0.40.30.5-0.80.90.5
Reaction time number correct0.70.92.7-0.5-0.50.4-1.0-1.01.30.81.10.0-0.6-1.6-1.30.7-1.3-1.0
Reaction time mean minus median0.00.00.3-0.20.5-0.3-0.10.1-0.20.1-0.1-0.10.00.10.1-0.0-0.00.0
Reaction time mean minus median AUC0.30.30.70.20.6-0.60.50.7-0.70.3-0.3-0.20.30.80.7-0.90.80.6
Reaction time num false alarms0.71.01.80.90.7-0.91.11.1-1.20.2-0.9-0.41.01.31.0-1.01.31.1
Reaction time num false alarms AUC0.81.13.00.70.5-0.80.91.3-1.2-0.0-0.7-0.10.71.61.2-1.41.71.4
Reaction time trials correct on left0.70.92.7-0.5-0.50.4-1.0-1.01.30.81.10.0-0.6-1.6-1.30.7-1.3-1.0
Reaction time trials on left0.71.02.7-0.5-0.60.5-1.0-1.11.30.81.10.1-0.6-1.7-1.30.7-1.3-1.0
Reaction time mean0.10.10.5-0.30.2-0.1-0.20.4-0.4-0.7-0.10.3-0.30.50.40.10.50.5
Reaction time mean AUC0.10.20.6-0.40.10.1-0.30.4-0.4-0.8-0.10.5-0.40.60.5-0.00.50.5
Median of all reaction times0.10.20.7-0.30.10.1-0.30.4-0.5-0.9-0.10.5-0.40.60.40.20.60.6
Reaction time omissions0.10.10.4-0.4-0.30.30.1-0.40.2-0.4-0.00.6-0.4-0.2-0.20.1-0.5-0.4
Reaction time false alarm rate1.72.45.80.90.7-0.91.41.8-1.8-0.4-1.2-0.10.92.41.9-1.92.41.9
Reaction time premature initiation rate3.14.17.4-2.5-2.62.7-1.9-1.82.0-2.32.02.5-2.3-1.3-1.51.4-1.4-1.5
Reaction time premature initiations2.94.15.6-2.2-2.32.4-2.0-2.02.3-1.42.12.0-2.1-2.0-2.01.6-1.9-1.8
Std. dev. reaction times0.00.10.30.10.5-0.50.00.2-0.3-0.40.00.1-0.10.20.10.20.20.0
Reaction time trials completed0.71.02.7-0.5-0.60.5-1.0-1.11.30.81.10.1-0.6-1.7-1.30.7-1.3-1.0
Reaction time trials AUC0.50.72.2-0.4-0.40.4-1.0-0.91.10.90.9-0.1-0.5-1.5-1.10.6-1.1-0.8
Social response proportion0.40.41.20.40.4-0.4-0.1-0.70.50.20.5-0.70.1-1.1-0.71.0-0.9-1.0
Social responses0.30.40.90.60.7-0.60.1-0.40.20.90.2-0.90.5-0.8-0.40.6-0.6-0.6
Social time0.50.61.2-0.7-0.40.5-1.1-0.90.8-0.90.90.7-0.9-1.0-0.80.5-0.8-0.8
Conditioned locomotion0.20.31.8-0.5-0.60.7-0.20.1-0.0-1.30.10.8-0.50.50.10.00.40.1
Cocaine response after cond. corrected1.21.42.51.21.2-1.01.21.3-1.30.6-1.6-1.01.01.11.2-1.30.91.2
Cocaine response after cond. not corrected3.13.45.11.61.6-1.31.82.2-2.11.3-2.1-1.51.42.02.1-2.21.82.1
Cocaine response before conditioning0.20.31.10.20.20.00.40.7-0.41.0-0.3-0.20.30.60.8-0.60.60.7
Saline control response1.72.35.3-0.8-1.11.2-0.7-1.91.6-0.21.00.6-0.6-2.0-2.22.1-2.3-2.1
Condit. Reinf. active minus inactive responses0.70.91.3-0.9-1.11.2-1.0-1.01.20.11.10.7-0.6-1.1-1.01.1-0.9-0.9
Condit. Reinf. active-inactive response ratio0.10.10.20.20.00.10.2-0.2-0.00.2-0.2-0.20.4-0.2-0.40.5-0.3-0.2
Condit. Reinf. active responses2.02.84.5-1.4-1.61.8-1.4-2.01.9-0.21.61.1-1.0-2.0-2.02.1-2.0-1.9
Condit. Reinf. inactive responses2.73.34.5-1.7-1.81.9-1.7-2.12.1-0.71.91.5-1.5-2.0-1.92.0-2.0-2.0
Condit. Reinf. lever presses0.60.91.4-0.8-1.11.0-0.7-1.11.10.21.00.7-0.4-1.0-1.21.2-1.0-1.1
Condit. Reinf. lever reinforcers received1.72.34.1-1.2-1.51.7-1.1-1.81.7-0.11.41.0-0.7-1.8-1.92.0-1.9-1.8
Pavlov. Cond. lever latency2.83.87.11.61.5-1.61.62.3-2.10.3-1.7-1.11.02.42.7-2.72.52.4
Pavlov. Cond. magazine entry latency0.00.00.10.1-0.1-0.30.10.00.10.40.0-0.00.2-0.00.0-0.10.1-0.1
Pavlov. Cond. change in total contacts1.31.83.4-1.0-1.20.9-1.1-1.71.6-0.21.30.8-0.6-1.6-1.81.8-1.6-1.7
Pavlov. Cond. index score1.31.72.9-1.1-1.21.0-1.1-1.61.5-0.21.30.9-0.7-1.6-1.71.7-1.5-1.6
Pavlov. Cond. latency score1.31.62.6-1.1-1.21.1-1.1-1.51.5-0.21.20.9-0.7-1.5-1.61.5-1.5-1.5
Pavlov. Cond. lever contacts3.34.58.4-1.7-1.71.7-1.7-2.62.3-0.41.81.2-1.1-2.6-2.92.9-2.8-2.7
Pavlov. Cond. magazine entry number0.10.10.20.20.10.20.30.2-0.3-0.3-0.5-0.10.10.40.3-0.30.10.3
Pavlov. Cond. intertrial magazine entries0.00.10.20.20.10.50.20.1-0.20.4-0.3-0.20.20.20.30.0-0.10.2
Pavlov. Cond. lever-magazine prob. diff.1.31.72.6-1.2-1.31.0-1.2-1.51.5-0.31.30.9-0.8-1.5-1.61.5-1.4-1.5
Pavlov. Cond. response bias1.62.24.6-1.2-1.11.0-1.2-1.81.6-0.11.40.7-0.6-1.8-2.02.2-1.8-1.9
Conditioned reinforcement - actives1.21.22.31.11.4-1.51.41.2-1.30.8-1.1-0.71.11.00.8-0.70.90.9
Conditioned reinforcement - inactives2.22.53.91.81.9-2.01.71.4-1.61.9-1.8-1.61.81.11.1-1.30.91.1
Conditioned locomotion0.81.01.60.70.9-0.91.21.3-1.10.9-0.9-0.70.81.01.0-0.81.11.2
Intermittent access intake day 1-15 change0.50.51.40.91.2-1.00.90.3-0.70.8-0.7-0.90.90.1-0.1-0.0-0.10.2
Intermittent access intake escalation0.30.31.00.61.0-0.70.60.3-0.60.7-0.5-0.60.70.1-0.1-0.00.00.3
Intermittent access intake escalation 20.10.10.3-0.00.1-0.0-0.5-0.30.30.10.5-0.1-0.1-0.5-0.50.4-0.2-0.2
Intermitt. access day 1 inactive lever presses0.30.30.9-0.6-0.40.6-0.2-0.60.50.40.10.5-0.4-0.6-0.60.6-0.9-0.6
Intermitt. access day 15 inactive lever presses0.60.62.20.90.7-0.90.6-0.40.21.50.1-0.80.8-0.9-0.90.6-0.8-0.6
Intermitt. access escalation Index0.50.41.1-0.3-0.50.5-0.1-0.90.7-0.40.70.3-0.2-0.7-0.80.8-0.8-1.1
Intermittent access day 1 total infusions0.30.31.00.40.4-1.00.70.5-0.6-0.3-0.3-0.10.30.70.5-0.50.90.5
Intermittent access day 15 total infusions0.80.92.81.21.3-1.71.40.8-1.00.5-0.8-0.81.10.70.4-0.60.80.6
Intermittent access terminal intake (last 3 days)0.20.20.80.60.7-0.90.70.3-0.40.3-0.2-0.40.50.20.1-0.20.30.2
Intermittent access total infusions0.50.61.20.90.9-1.10.90.7-0.80.5-0.7-0.60.70.60.5-0.60.70.7
Intermittent access day 1 locomotion1.31.32.3-1.2-1.10.7-0.8-1.21.2-1.51.01.1-1.1-1.0-1.31.3-1.0-1.2
Intermittent access day 15 total locomotion1.61.83.01.51.6-1.71.61.3-1.60.8-1.0-0.91.31.41.0-1.11.51.3
Intermittent access total locomotion0.40.51.10.91.0-0.91.10.4-0.70.6-0.8-0.81.00.30.1-0.30.20.3
Intermittent access standard deviation0.80.81.3-0.9-0.90.3-0.7-0.91.1-0.71.21.1-1.0-0.9-0.91.1-0.8-0.9
Cocaine induced anxiety0.91.04.01.41.1-0.90.90.2-0.32.0-0.7-1.81.3-0.5-0.30.2-0.5-0.1
Post-drug Anxiety0.50.51.90.81.0-0.80.30.4-0.51.4-0.7-1.20.9-0.10.1-0.2-0.10.1
Baseline Anxiety0.60.71.60.20.8-0.80.20.9-1.0-0.5-0.40.10.31.21.1-1.11.20.9
Lifetime Intake0.60.61.20.80.9-1.10.80.9-0.90.5-0.8-0.70.70.70.7-0.80.80.9
Incentive Sensitization - Responses0.20.21.90.80.6-1.40.10.2-0.4-0.3-0.0-0.30.30.20.1-0.30.40.0
Incentive Sensitization - Breakpoint0.20.21.90.70.6-1.40.10.2-0.4-0.30.0-0.20.30.30.2-0.30.50.1
Progressive ratio test 1 active lever presses1.51.53.01.31.6-1.51.51.0-1.31.3-1.7-1.51.60.80.7-0.80.40.7
Progressive ratio test 1 breakpoint1.11.22.51.01.3-1.31.40.9-1.31.0-1.6-1.11.30.80.7-0.80.40.7
Progressive ratio test 1 inactive lever presses3.13.36.21.92.0-2.01.91.6-1.82.5-2.1-2.32.31.21.3-1.51.01.4
Progressive ratio test 2 active lever presses0.70.72.61.01.1-1.60.80.7-0.90.3-0.8-0.80.90.60.4-0.60.60.6
Progressive ratio test 2 breakpoint0.50.52.51.01.0-1.60.70.4-0.70.4-0.7-0.90.90.30.1-0.30.20.2
Progressive ratio test 2 inactive lever presses1.41.75.61.91.7-2.41.70.9-1.11.2-0.7-1.21.50.60.5-0.60.90.5
Total sessions with >9 infusions0.00.00.1-0.3-0.20.1-0.30.00.10.10.00.2-0.20.00.0-0.00.00.2
Short access day 1 total inactive lever presses1.61.83.71.61.2-1.21.31.3-1.11.9-1.2-1.81.50.81.1-1.21.01.3
Short access day 10 total inactive lever presses0.30.31.2-0.4-0.71.1-0.2-0.50.70.60.20.2-0.3-0.7-0.40.5-0.9-0.5
Short access day 1 total infusions0.30.30.70.20.1-0.10.30.8-0.60.1-0.50.00.10.80.7-0.80.80.8
Short access day 10 total infusions0.10.10.2-0.4-0.40.1-0.2-0.10.3-0.20.10.3-0.3-0.2-0.30.2-0.1-0.0
Short access total infusions0.10.10.5-0.1-0.1-0.20.10.5-0.30.0-0.30.1-0.10.50.5-0.50.60.7
Short access day 1 locomotion0.91.02.4-1.5-1.41.6-1.2-0.50.9-0.70.91.3-1.3-0.3-0.10.3-0.0-0.1
Short access day 10 total locomotion2.22.44.2-1.5-1.61.4-1.2-1.91.8-1.00.80.9-1.2-1.8-1.71.7-2.0-1.8
Short access total locomotion3.94.06.2-2.4-2.52.2-1.9-2.02.3-1.61.81.9-2.1-1.9-1.81.9-1.8-1.7
Compulsive drug intake3.02.96.5-2.2-2.02.5-1.9-1.41.5-2.01.32.2-2.1-1.0-1.11.4-1.3-1.1
One hour access (0.3 mA shock)0.40.40.90.60.9-0.80.70.6-0.80.4-0.9-0.70.70.50.5-0.40.40.5
One hour access (shock baseline)3.23.87.02.32.4-2.62.21.6-1.92.0-2.1-2.32.31.21.3-1.41.11.3
Number of responses in last shaping day0.30.30.9-0.6-0.50.8-0.2-0.40.4-1.00.50.7-0.4-0.3-0.80.7-0.2-0.4
Context. condit. distance diff. score2.12.64.2-2.0-1.71.9-1.5-1.61.5-1.61.61.9-1.8-1.2-1.41.3-1.3-1.3
Locomotion velocity, session 11.11.23.9-0.0-0.10.2-0.3-1.41.0-0.00.5-0.30.0-1.7-1.61.5-2.0-1.8
Locomotion distance, session 11.01.32.8-1.3-1.41.7-0.9-1.11.1-1.30.71.1-1.1-0.9-0.90.8-1.2-1.1
Locomotion velocity, session 21.21.45.3-0.20.10.2-0.8-1.51.00.30.1-0.70.0-2.0-1.71.5-2.3-1.7
Locomotion distance, session 22.73.97.4-1.4-1.71.6-1.6-2.52.1-1.71.51.2-1.3-2.4-2.51.9-2.7-2.7
Locomotion velocity, session 30.70.81.6-1.2-1.11.3-0.6-0.90.9-0.90.61.0-0.9-0.6-0.80.5-0.9-0.9
Locomotion distance, session 30.30.30.80.90.5-0.70.9-0.2-0.10.5-0.5-0.80.8-0.3-0.4-0.2-0.6-0.5
Stereotopy head waving bouts, day 31.01.22.4-1.3-1.31.5-1.2-1.11.2-1.01.00.9-1.1-1.0-0.81.1-1.1-0.9
Stereotopy head waving duration, day 32.32.84.1-1.9-1.82.0-1.5-1.61.7-1.71.71.7-1.7-1.4-1.51.6-1.5-1.5
Locomotion velocity, session 70.40.41.30.60.1-0.10.2-0.40.21.1-0.1-0.70.8-0.6-0.71.0-0.8-0.6
Locomotion distance, session 70.81.02.6-0.5-0.81.0-0.5-1.10.9-0.70.60.6-0.4-1.1-1.41.6-1.5-1.3
Stereotopy head waving bouts, day 70.10.10.3-0.30.0-0.10.30.1-0.3-0.6-0.20.4-0.10.40.1-0.50.30.1
Stereotopy head waving duration, day 70.30.31.00.00.3-0.40.70.6-0.6-0.2-0.40.10.20.80.6-1.00.90.6
Locomotion velocity, session 82.53.05.2-1.1-1.21.3-1.7-2.21.9-1.21.60.9-1.3-2.2-2.12.0-2.3-2.1
Locomotion distance, session 87.310.813.0-3.5-3.43.6-3.3-3.43.4-3.23.23.3-3.4-3.0-3.22.9-3.1-3.2
Degree of sensitization distance4.04.16.3-2.3-2.12.5-2.4-1.82.0-1.82.12.1-2.2-1.6-1.62.3-1.6-1.6
Degree of sensitization stereotypy0.60.61.80.20.6-0.80.80.9-0.90.1-0.6-0.20.41.10.8-1.31.10.9
Condit. Reinf. active minus inactive responses0.50.51.60.80.3-0.20.6-0.70.30.4-0.1-0.50.6-0.9-1.01.0-1.3-1.0
Condit. Reinf. active-inactive response ratio2.12.36.40.0-0.20.1-0.3-2.01.4-0.20.80.1-0.2-2.2-2.32.3-2.5-2.3
Condit. Reinf. active responses0.30.31.00.5-0.10.20.2-0.70.50.10.3-0.10.1-0.8-0.90.9-1.0-0.9
Condit. Reinf. inactive responses0.50.51.60.40.10.10.21.0-0.60.4-0.1-0.10.11.01.2-1.11.31.1
Incentive salience index mean0.50.61.81.30.8-0.71.10.0-0.31.1-0.6-1.01.2-0.2-0.30.3-0.5-0.3
Condit. Reinf. lever presses0.40.61.21.10.8-0.71.10.7-0.71.1-0.6-0.81.00.60.5-0.30.60.5
Time in familiar zone, hab. session 11.81.72.6-1.2-1.30.7-1.4-1.51.4-1.61.41.4-1.5-1.2-1.30.9-1.0-1.4
Time in novel zone, hab. session 11.61.52.61.01.0-0.60.91.5-1.21.6-1.2-1.21.11.21.4-1.21.21.6
Total zone transitions, hab. session 11.11.53.1-0.6-1.00.7-0.8-1.61.4-0.70.90.4-0.6-1.7-1.81.5-1.7-1.7
Total locomotion distance, hab. session 10.20.31.3-0.1-0.10.00.1-0.60.40.1-0.3-0.30.2-0.8-0.80.5-1.1-0.8
Locomotion velocity, hab. session 10.30.51.9-0.2-0.20.20.0-0.90.6-0.10.0-0.10.0-1.0-1.10.8-1.4-1.1
Time in familiar zone, hab. session 23.53.67.3-2.7-1.92.0-2.0-1.71.6-2.71.82.4-2.3-1.1-1.31.5-1.1-1.3
Time in novel zone, hab. session 22.42.46.72.11.5-1.71.41.3-1.12.6-1.0-2.11.90.81.1-1.21.11.1
Total zone transitions, hab. session 20.30.40.80.60.1-0.20.3-0.60.40.40.1-0.80.5-0.9-0.80.4-0.9-0.9
Total locomotion distance, hab. session 20.30.41.00.80.5-0.70.5-0.40.20.9-0.1-1.00.7-0.7-0.60.3-0.7-0.6
Locomotion velocity, hab. session 20.40.51.61.10.8-0.90.8-0.0-0.21.0-0.5-1.31.0-0.4-0.30.0-0.4-0.3
Novel to familiar place preference ratio1.51.64.32.11.4-1.61.70.3-0.71.6-1.3-1.91.9-0.2-0.30.1-0.6-0.3
Novelty place preference1.51.53.92.01.4-1.51.60.4-0.71.7-1.2-1.91.9-0.1-0.20.1-0.4-0.2
Time in novel zone, NPP test1.31.33.41.81.2-1.41.50.2-0.61.7-1.0-1.71.8-0.2-0.30.1-0.5-0.3
Total zone transitions, NPP test0.10.10.5-0.4-0.50.7-0.20.00.1-0.30.00.3-0.20.20.1-0.30.10.1
Total locomotion distance, NPP test0.00.00.20.00.10.10.30.1-0.20.2-0.4-0.20.40.30.1-0.30.00.1
Locomotion velocity, NPP test0.20.20.70.30.4-0.20.60.4-0.60.2-0.8-0.50.60.50.4-0.50.20.4
Pavlov. Cond. lever latency0.20.30.80.70.9-0.70.60.4-0.60.4-0.8-0.80.50.10.3-0.1-0.10.3
Pavlov. Cond. magazine entry latency1.21.62.2-1.3-1.31.2-1.2-1.51.5-0.81.10.9-1.0-1.4-1.41.2-1.4-1.4
Pavlov. Cond. change in total contacts0.40.51.41.00.6-0.90.7-0.1-0.20.8-0.5-1.21.1-0.3-0.3-0.0-0.3-0.4
Pavlov. Cond. index score1.11.42.0-1.3-1.41.3-1.1-1.31.3-0.91.21.1-1.0-1.0-1.10.9-1.0-1.2
Pavlov. Cond. latency score1.01.32.1-1.4-1.41.3-1.2-1.21.3-0.91.31.2-1.0-0.9-1.10.9-0.8-1.1
Pavlov. Cond. lever contacts0.40.51.0-0.8-0.90.8-0.7-0.70.8-0.41.00.7-0.5-0.5-0.60.6-0.4-0.6
Pavlov. Cond. magazine entry number1.62.03.61.21.3-1.21.01.8-1.60.6-1.1-0.70.81.81.8-1.61.91.9
Pavlov. Cond. intertrial magazine entries1.41.73.70.80.5-0.00.81.7-1.40.8-1.1-0.40.71.81.9-1.71.71.9
Pavlov. Cond. lever-magazine prob. diff.1.11.32.0-1.3-1.41.4-1.1-1.31.3-0.91.21.1-1.0-1.0-1.10.9-1.0-1.1
Pavlov. Cond. response bias0.10.20.3-0.3-0.40.5-0.2-0.50.50.00.20.1-0.1-0.5-0.50.5-0.6-0.6
Bone: apparent density0.20.30.9-0.7-0.60.9-0.50.10.0-0.8-0.30.4-0.60.40.5-0.50.20.4
Bone surface0.30.51.30.60.5-0.60.80.7-0.70.3-0.9-0.60.60.80.8-1.10.50.6
Bone volume0.20.30.80.30.3-0.20.40.6-0.6-0.0-0.8-0.40.30.80.9-0.90.60.7
Bone: connectivity density0.10.20.8-0.6-0.60.8-0.20.00.1-0.9-0.20.6-0.60.20.2-0.50.00.1
Bone: cortical apparent density0.00.10.2-0.4-0.0-0.2-0.00.1-0.1-0.50.20.10.00.40.10.10.50.2
Bone: cortical area3.04.67.12.01.9-2.12.12.3-2.02.7-1.4-1.72.02.02.3-2.62.42.2
Bone: cortical porosity0.70.81.50.70.6-0.50.71.0-0.90.8-1.1-0.60.71.01.1-1.20.91.1
Bone: cortical porosity0.20.20.50.30.1-0.20.30.5-0.40.3-0.5-0.00.20.50.6-0.70.50.5
Bone: cortical thickness2.43.97.51.71.4-1.71.82.3-1.92.0-1.2-1.21.62.22.3-2.72.62.3
Bone: cortical thickness0.40.51.9-0.5-0.80.60.10.3-0.1-1.40.30.9-0.60.80.4-0.90.80.5
Bone: cortical tissue density0.10.10.2-0.40.1-0.20.10.1-0.2-0.50.1-0.00.10.40.20.10.50.2
Bone: elastic displacement0.40.51.1-0.7-0.90.7-0.7-0.10.4-0.90.71.1-1.00.30.5-0.50.50.2
Bone: elastic work0.81.03.2-0.2-0.30.2-0.01.1-0.5-0.10.20.6-0.61.41.7-1.61.81.4
Bone: endosteal estimation0.00.00.30.00.1-0.1-0.10.1-0.00.6-0.0-0.20.2-0.00.2-0.30.10.1
Bone: endosteal perimeter0.61.22.81.21.2-1.21.11.0-0.91.7-1.0-1.21.20.60.8-1.40.70.8
Bone: final force0.10.10.40.10.0-0.40.30.3-0.00.30.50.20.10.20.3-0.40.60.2
Bone: final moment0.20.30.70.20.2-0.50.30.5-0.30.60.2-0.10.20.50.7-0.90.90.5
Bone: marrow area0.00.00.2-0.00.1-0.1-0.10.10.00.5-0.0-0.20.1-0.10.1-0.20.00.1
Bone: maximum diameter3.15.712.52.72.7-2.82.52.3-2.13.5-1.6-2.62.71.62.0-2.21.91.9
Bone: maximum force0.10.20.6-0.2-0.0-0.30.00.3-0.10.40.40.1-0.00.30.6-0.80.80.4
Bone: maximum moment0.20.41.4-0.10.1-0.40.00.6-0.30.80.2-0.10.10.60.9-1.21.00.7
Bone: minimum diameter0.10.10.6-0.3-0.20.2-0.20.30.00.60.20.1-0.10.20.5-0.80.40.4
Bone: periosteal estimation0.81.63.41.01.1-1.21.11.4-1.11.8-0.7-1.11.21.11.4-1.71.41.3
Bone: periosteal perimeter2.44.06.62.01.9-2.12.12.1-1.92.6-1.5-1.72.01.71.9-2.41.91.9
Bone: post-yield work0.10.20.50.30.5-0.5-0.30.3-0.20.7-0.3-0.70.30.10.4-0.50.20.3
Bone: stiffness0.10.10.6-0.8-0.30.4-0.1-0.30.30.10.40.30.0-0.3-0.50.5-0.2-0.3
Bone: tissue strength0.50.51.8-0.8-0.60.4-1.3-0.30.70.31.30.6-0.9-0.40.1-0.10.3-0.1
Bone: trabecular number0.30.51.1-0.4-0.20.5-0.10.8-0.5-0.6-0.60.2-0.31.01.1-1.00.81.0
Bone: trabecular spacing0.30.41.61.20.6-1.30.5-0.30.20.90.3-0.60.5-0.6-0.60.3-0.3-0.6
Bone: trabecular thickness0.81.02.6-1.6-1.01.6-1.10.4-0.1-1.40.01.1-1.20.80.9-0.60.70.9
Bone: trabecular tissue density0.20.30.8-0.4-0.20.2-0.7-0.70.5-0.30.60.3-0.3-0.7-0.80.9-0.7-0.7
Breakpoint value in progressive ratio session0.30.40.80.40.8-0.3-0.10.4-0.70.9-0.6-0.90.80.70.6-0.10.50.6
Distance traveled before self-admin0.20.20.50.0-0.00.4-0.2-0.40.20.2-0.7-0.70.3-0.4-0.50.3-0.6-0.3
Distance traveled after self-admin0.20.20.70.40.3-0.50.40.1-0.4-0.1-0.8-0.70.60.20.0-0.20.10.0
Delta time in closed arm before/after self-admin2.22.18.4-2.1-1.72.9-2.0-1.01.0-1.40.91.8-1.7-0.4-0.30.5-0.7-0.5
Delta time in open arm before/after self-admin3.43.28.12.42.2-2.92.21.2-1.52.1-1.4-2.32.40.70.6-1.10.90.8
Diff in mean of infusions in LGA sessions0.10.10.40.20.3-0.10.30.1-0.4-0.5-0.60.00.20.50.2-0.30.20.1
Extinction: sum of active levers before priming1.11.12.61.21.5-0.91.10.5-1.11.3-1.6-1.61.60.40.3-0.2-0.20.1
Active lever presses in extinction session 62.12.03.11.01.3-1.61.11.6-1.70.9-1.8-1.11.21.71.6-1.71.31.6
Delta distance traveled before/after self-admin0.30.31.10.40.3-1.11.00.5-0.5-0.6-0.10.20.20.60.3-0.50.60.2
Delta ambulatory time before/after self-admin0.10.11.20.0-0.0-0.40.50.2-0.2-1.1-0.00.5-0.20.30.1-0.20.2-0.1
Time in closed arm before self-admin0.20.20.7-0.5-0.70.4-0.2-0.10.5-0.50.80.5-0.6-0.3-0.00.60.20.1
Time in closed arm after self-admin1.71.87.0-1.9-1.72.6-1.6-0.61.0-1.21.21.7-1.7-0.20.00.7-0.1-0.1
Time in open arm before self-admin0.00.00.1-0.2-0.10.3-0.20.1-0.1-0.2-0.00.4-0.30.20.1-0.30.00.1
Time in open arm after self-admin0.60.72.21.11.1-1.50.9-0.0-0.31.0-0.4-1.01.1-0.4-0.60.0-0.5-0.4
Sum of active levers in priming session hrs 5-61.11.11.90.71.1-1.40.71.1-1.30.7-1.0-0.70.91.41.3-1.01.11.0
Time to tail flick, vehicle, before self-admin0.30.30.90.20.1-0.90.10.5-0.4-0.30.20.5-0.10.80.7-0.81.00.6
Time to tail flick, vehicle, after self-admin0.20.20.7-0.3-0.5-0.1-0.3-0.70.5-0.80.10.7-0.5-0.4-0.30.1-0.6-0.7
Time to tail flick, test, before self-admin0.90.91.5-0.9-1.00.9-1.1-0.81.10.01.00.9-0.8-1.0-0.91.2-0.9-0.8
Time to tail flick, test, after self-admin1.11.15.31.30.6-1.10.30.9-0.52.3-0.4-1.41.10.50.8-1.10.91.0
Delta time to tail flick, vehicle, before/after SA0.50.51.2-0.3-0.40.5-0.6-0.90.6-0.8-0.00.3-0.4-0.8-0.80.8-1.1-0.9
Delta time to tail flick, test, before/after SA1.31.22.41.31.1-1.00.91.0-0.91.6-0.8-1.41.10.71.0-1.10.91.0
Ambulatory time before self-admin0.10.10.7-0.1-0.00.4-0.4-0.1-0.10.1-0.9-0.60.3-0.0-0.10.0-0.2-0.0
Ambulatory time after self-admin0.10.10.80.10.2-0.10.2-0.1-0.3-0.5-0.9-0.60.50.2-0.1-0.1-0.1-0.1
Total heroin consumption0.10.10.3-0.20.20.3-0.10.3-0.40.5-0.3-0.30.20.50.6-0.10.40.4
Area under the delay curve7.78.311.63.23.1-3.13.42.8-3.12.5-3.0-3.03.32.62.5-2.62.42.3
Delay disc. indifference point, 0s delay6.67.210.82.62.6-2.83.32.8-3.21.0-2.9-1.82.63.12.7-2.82.72.5
Delay disc. indifference point, 16s delay4.84.87.42.52.7-2.42.71.8-2.32.2-2.4-2.72.71.61.6-1.71.31.5
Delay disc. indifference point, 2s delay6.06.78.72.62.4-2.62.92.8-2.91.5-2.9-1.92.52.92.6-2.82.72.6
Delay disc. indifference point, 24s delay3.93.85.72.12.4-2.22.42.0-2.41.1-2.3-1.92.11.81.5-1.31.41.6
Delay disc. indifference point, 4s delay5.45.78.62.62.3-2.52.92.4-2.52.3-2.7-2.32.62.12.0-2.31.92.1
Delay disc. indifference point, 8s delay1.21.22.51.51.3-1.41.30.7-0.91.4-0.9-1.61.60.50.5-0.60.50.4
Delay discount exponential model param7.27.610.8-3.1-3.03.0-3.3-2.73.0-2.42.92.8-3.1-2.5-2.32.4-2.3-2.3
Delay discount hyperbolic model param7.68.011.6-3.2-3.03.1-3.4-2.83.1-2.43.02.8-3.2-2.6-2.42.6-2.4-2.3
Fecal boli incidents, locomotor time 10.50.51.1-0.6-0.50.8-0.9-0.90.8-0.20.40.1-0.3-0.9-0.71.0-1.1-0.8
Change in fecal boli incidents, locomotor task1.41.32.9-0.5-0.50.3-1.0-1.31.2-0.60.90.6-0.8-1.6-1.71.7-1.6-1.4
Time >=10cm from walls, locomotor time 10.50.53.1-0.5-0.20.3-0.40.2-0.2-1.80.61.4-0.80.70.1-0.20.80.3
Bouts of movement, locomotor time 10.10.20.60.50.5-0.80.7-0.2-0.2-0.5-0.1-0.00.30.10.10.4-0.3-0.3
Total resting periods, locomotor time 10.20.30.80.60.6-0.90.9-0.4-0.2-0.3-0.2-0.00.3-0.2-0.20.6-0.6-0.5
Rest time, locomotor task time 10.50.51.4-0.1-0.2-0.4-0.3-0.90.70.20.50.0-0.1-1.0-1.01.2-1.2-1.0
Distance moved, locomotor task time 10.30.31.2-0.2-0.20.2-0.20.6-0.3-0.50.1-0.0-0.20.70.8-1.11.10.8
Vertical activity count, locomotor time 10.10.10.7-0.4-0.10.3-0.3-0.10.0-0.9-0.1-0.1-0.30.00.0-0.40.20.1
Time >=10cm from walls, locomotor time 20.20.30.4-0.7-0.40.7-0.6-0.40.4-0.60.50.6-0.6-0.3-0.40.4-0.4-0.5
Bouts of movement, locomotor time 20.30.31.20.30.2-0.11.10.4-0.50.7-0.5-0.00.50.70.8-0.60.40.5
Total resting periods, locomotor time 20.30.31.40.40.2-0.11.20.3-0.40.7-0.5-0.20.70.60.6-0.30.20.2
Rest time, locomotor task time 20.60.72.1-0.5-0.70.4-0.7-1.01.0-0.30.80.5-0.6-1.0-1.01.4-1.1-1.1
Distance moved, locomotor task time 20.10.20.7-0.5-0.20.1-0.20.2-0.0-0.80.40.4-0.40.30.3-0.50.50.3
Vertical activity count, locomotor time 20.20.20.40.10.3-0.10.30.4-0.5-0.4-0.6-0.30.10.50.4-0.60.40.5
Weight adjusted by age1.11.22.21.10.8-1.11.31.1-1.01.0-0.8-0.71.01.31.3-1.51.41.0
Seeking ratio, delayed vs. immediate footshock0.40.51.4-0.4-0.00.6-0.7-0.70.51.0-0.3-0.70.1-1.0-0.70.8-1.2-0.7
Locomotion in novel chamber0.40.62.2-1.0-0.80.6-0.6-0.10.2-1.40.51.5-1.00.40.10.00.30.1
Locomotion in novel chamber post-restriction2.42.95.2-1.4-1.21.3-1.3-2.01.6-1.71.31.4-1.2-1.8-2.32.1-2.1-2.2
Progressive ratio0.20.21.00.50.3-0.30.00.4-0.3-0.3-0.2-0.1-0.00.40.5-1.00.80.5
Food seeking constrained by brief footshock3.13.87.31.91.5-2.01.72.1-2.01.2-1.9-1.51.62.02.0-2.72.32.1
Seeking ratio, punishment vs. effort0.81.02.20.90.7-0.91.31.0-1.01.5-1.1-1.11.20.90.8-0.80.71.0
Run reversals in cocaine runway, females0.50.53.5-0.5-0.40.2-0.2-0.60.4-1.90.41.0-0.7-0.3-0.50.5-0.3-0.7
Run reversals in cocaine runway, males0.00.00.20.10.20.20.30.1-0.10.5-0.2-0.20.10.10.2-0.10.10.2
Latency to leave start box in cocaine runway0.20.20.70.50.3-0.40.80.3-0.30.4-0.8-0.30.60.1-0.2-0.4-0.20.0
Latency to leave start box in cocaine runway, F0.10.10.50.20.0-0.50.60.4-0.20.3-0.10.30.10.40.1-0.70.50.2
Latency to leave start box in cocaine runway, M0.50.51.50.70.4-0.00.5-0.1-0.20.6-1.2-1.10.8-0.5-0.50.3-1.1-0.4
Cd content in liver1.11.23.2-1.0-1.21.3-1.1-0.91.0-1.81.11.2-1.3-0.6-0.91.1-0.6-0.7
Co content in liver0.40.51.00.80.6-0.30.90.7-0.80.9-1.0-0.71.00.70.6-0.30.30.5
Cu content in liver0.20.20.60.30.5-0.00.40.6-0.7-0.1-0.8-0.30.30.60.5-0.20.40.6
Fe content in liver1.72.15.8-0.7-0.40.6-0.9-1.91.40.00.70.1-0.4-2.1-2.02.2-2.4-2.0
K content in liver2.12.13.61.21.0-0.81.41.7-1.70.5-1.6-0.81.01.81.9-1.81.71.8
Mg content in liver3.33.44.41.71.7-1.51.92.1-2.01.7-1.8-1.51.71.92.1-2.01.82.0
Mn content in liver0.50.62.30.20.2-0.20.50.7-0.60.7-1.0-0.60.60.80.9-1.50.60.9
Na content in liver4.54.88.02.72.8-2.82.71.6-2.12.6-2.5-2.82.81.01.2-1.20.61.1
Rb content in liver1.21.52.21.51.2-1.21.21.4-1.40.6-1.2-1.21.21.31.2-1.21.31.3
Se content in liver2.42.94.11.51.7-1.51.41.9-1.81.6-1.7-1.51.31.61.9-2.01.72.0
Sr content in liver0.50.41.20.90.6-1.00.3-0.30.21.10.3-0.80.5-0.8-0.60.5-0.5-0.6
Zn content in liver0.10.21.00.40.2-0.1-0.20.40.01.00.2-0.60.0-0.00.5-0.20.40.5