Spdya

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000004534	0.04	0.04	8.2e-04	0.03	0.02	0.02	0.03	6.2e-04	1.0e-03	1.1e-03	8.2e-04
2	BLA	intron excision ratio	chr6:23948399:23954790	0.09	0.13	9.1e-03	0.03	0.02	0.03	0.03	6.0e-03	3.6e-02	8.2e-03	1.0e-02
3	Brain	intron excision ratio	chr6:23948399:23950703	0.03	0.03	3.7e-03	0.01	0.02	0.01	0.01	1.3e-02	1.2e-02	1.3e-02	2.3e-02
4	Brain	intron excision ratio	chr6:23948399:23954790	0.02	0.02	9.1e-03	0.02	0.02	0.02	0.01	8.3e-03	1.0e-02	1.0e-02	1.8e-02
5	Brain	mRNA stability	ENSRNOG00000004534	0.04	0.04	1.4e-03	0.02	0.01	0	0.01	7.1e-03	2.9e-02	9.4e-02	2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.3	0.8	1.3	-1.0	-0.7	1.0	-1.2	-0.7
BMI without tail	0.1	0.2	0.5	-0.5	-0.3	0.6	-0.7	-0.3
Body weight	1.6	6.6	7.3	-2.4	-2.6	2.7	-2.7	-2.5
Epididymis fat weight	15.4	36.0	37.5	-6.0	-6.1	6.0	-5.8	-6.0
Glucose	0.6	0.9	1.2	-1.1	-1.0	0.9	-0.9	-1.0
Heart weight	9.6	13.7	14.9	-3.5	-3.7	3.9	-3.7	-3.6
Left kidney weight	0.1	0.2	0.7	0.8	0.1	-0.2	0.7	0.1
Right kidney weight	0.5	1.3	1.7	-0.7	-1.3	1.3	-0.9	-1.3
Tail length	0.2	0.6	0.9	-0.6	-1.0	0.8	-0.7	-0.9
Length with tail	1.5	5.6	6.9	-2.1	-2.6	2.4	-2.2	-2.5
Length without tail	0.9	2.0	2.5	-1.3	-1.6	1.4	-1.3	-1.5
Liver weight, left	2.1	3.4	4.2	-1.8	-2.0	1.8	-1.5	-2.0
Liver weight, right	9.9	16.4	17.7	-3.9	-4.2	4.1	-3.9	-4.2
Parametrial fat weight	5.4	10.6	12.2	-3.4	-3.0	3.2	-3.5	-3.1
Retroperitoneal fat weight	21.4	70.9	72.7	-8.4	-8.4	8.5	-8.5	-8.3
Intraocular pressure	3.1	4.4	4.8	-1.9	-2.1	2.2	-2.1	-2.1
Extensor digitorum longus weight	4.9	19.7	20.6	4.4	4.5	-4.5	4.2	4.5
Soleus weight	5.6	16.4	17.7	4.0	4.1	-4.1	3.8	4.2
Tibialis anterior weight	4.3	14.7	16.1	3.8	4.0	-3.8	3.5	4.0
Tibia length	2.8	8.0	8.4	-2.8	-2.9	2.9	-2.9	-2.7
Number of licking bursts	0.1	0.2	0.2	0.3	0.4	-0.5	0.5	0.4
Food consumed during 24 hour testing period	0.2	0.3	0.5	0.7	0.5	-0.5	0.4	0.4
Times rat made contact with spout	2.4	2.8	2.9	1.6	1.7	-1.7	1.7	1.6
Mean time between licks in bursts	2.6	3.6	4.0	-1.9	-1.9	1.9	-1.7	-2.0
Mean num. licks in bursts	0.1	0.2	0.2	0.5	0.4	-0.4	0.3	0.4
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.5	-0.1	0.2	-0.3	-0.2
Water consumed over 24 hours	1.2	1.4	1.9	1.4	1.1	-1.2	1.3	1.0
Indifference point 0 sec	0.2	0.4	0.5	-0.6	-0.6	0.6	-0.7	-0.5
Indifference point AUC	1.1	1.2	1.7	1.0	1.2	-1.3	0.9	1.2
Indifference point function ln k	0.0	0.0	0.0	-0.0	-0.1	0.1	0.2	-0.0
Indifference point function log k	0.0	0.0	0.0	-0.0	-0.1	0.1	0.2	-0.0
Delay discounting total patch changes 0 sec	0.1	0.2	0.4	-0.4	-0.4	0.5	-0.6	-0.3
Delay discounting total patch changes 12 sec	0.7	0.9	1.4	-1.0	-0.9	0.9	-1.2	-0.9
Delay discounting total patch changes 18 sec	0.0	0.1	0.2	-0.1	-0.1	0.1	-0.5	-0.0
Delay discounting total patch changes 24 sec	1.5	1.9	2.1	-1.4	-1.4	1.3	-1.4	-1.4
Delay discounting total patch changes 6 sec	0.0	0.1	0.3	-0.1	0.0	0.1	-0.6	0.0
Delay discounting time to switch 0 sec	0.1	0.2	0.3	0.6	0.5	-0.4	0.5	0.4
Delay discounting water rate 0 sec	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.3	-0.2
Delay discounting water rate 12 sec	1.6	2.4	3.2	-1.3	-1.8	1.7	-1.3	-1.6
Delay discounting water rate 18 sec	0.3	0.4	0.6	-0.2	-0.8	0.7	-0.4	-0.6
Delay discounting water rate 24 sec	1.9	2.6	3.1	-1.6	-1.6	1.7	-1.8	-1.4
Delay discounting water rate 6 sec	1.3	1.8	2.3	-1.2	-1.5	1.5	-1.2	-1.4
Locomotor activity	0.0	0.0	0.1	0.1	0.3	-0.2	-0.0	0.2
Locomotor testing distance	0.6	1.0	1.2	1.0	1.1	-1.0	0.9	1.0
Locomotor testing rearing	0.5	0.8	1.2	0.8	1.1	-1.0	0.7	1.0
Light reinforcement 1	4.2	7.7	9.1	2.5	3.0	-2.8	2.5	3.0
Light reinforcement 2	3.2	4.3	4.5	2.1	2.0	-2.1	2.0	2.1
Reaction time number correct	0.7	0.9	1.4	1.0	0.8	-0.9	1.2	0.9
Reaction time mean minus median	0.1	0.1	0.2	0.1	0.4	-0.2	0.2	0.4
Reaction time mean minus median AUC	0.0	0.0	0.0	-0.2	0.2	-0.0	0.0	0.2
Reaction time num false alarms	0.3	0.4	0.6	0.8	0.7	-0.7	0.6	0.6
Reaction time num false alarms AUC	0.6	0.9	1.3	1.1	0.9	-0.9	0.9	0.9
Reaction time trials correct on left	0.7	0.9	1.4	1.0	0.8	-0.9	1.2	0.9
Reaction time trials on left	0.7	1.0	1.5	1.0	0.8	-0.9	1.2	1.0
Reaction time mean	0.6	0.9	1.3	-1.0	-0.7	1.0	-1.1	-0.8
Reaction time mean AUC	0.5	0.7	1.0	-0.9	-0.6	0.9	-1.0	-0.7
Median of all reaction times	0.8	1.0	1.5	-1.1	-0.8	1.0	-1.2	-0.9
Reaction time omissions	0.1	0.2	0.3	0.1	0.6	-0.4	0.3	0.5
Reaction time false alarm rate	0.0	0.1	0.1	0.4	0.3	-0.3	0.1	0.2
Reaction time premature initiation rate	0.1	0.2	0.3	-0.5	-0.4	0.4	-0.3	-0.4
Reaction time premature initiations	0.0	0.0	0.2	0.1	0.1	-0.1	0.4	0.2
Std. dev. reaction times	0.2	0.3	0.4	-0.6	-0.4	0.6	-0.6	-0.4
Reaction time trials completed	0.7	1.0	1.5	1.0	0.8	-0.9	1.2	1.0
Reaction time trials AUC	0.9	1.3	1.9	1.2	1.0	-1.1	1.4	1.1
Social response proportion	0.3	0.4	0.7	-0.7	-0.3	0.6	-0.9	-0.2
Social responses	0.0	0.1	0.2	-0.1	0.1	0.2	-0.5	0.1
Social time	0.6	0.7	1.2	-0.8	-0.6	1.0	-1.1	-0.6
Conditioned locomotion	3.0	3.6	4.9	2.0	1.7	-1.9	2.2	1.7
Cocaine response after cond. corrected	2.1	2.4	2.6	1.5	1.6	-1.6	1.5	1.6
Cocaine response after cond. not corrected	3.4	3.8	4.1	1.9	1.9	-2.0	2.0	1.9
Cocaine response before conditioning	0.7	0.9	1.0	1.0	0.9	-0.9	1.0	0.9
Saline control response	0.8	1.1	1.6	0.9	1.1	-1.0	0.8	1.3
Condit. Reinf. active minus inactive responses	3.7	4.5	5.3	2.2	2.0	-2.2	2.3	2.0
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.2	1.0	0.7	-0.9	1.1	0.6
Condit. Reinf. active responses	2.9	4.0	4.7	2.1	1.8	-2.0	2.2	1.8
Condit. Reinf. inactive responses	1.8	2.3	2.6	1.5	1.5	-1.5	1.6	1.4
Condit. Reinf. lever presses	1.7	2.4	2.8	1.7	1.4	-1.6	1.7	1.4
Condit. Reinf. lever reinforcers received	2.4	3.4	3.9	1.9	1.7	-1.9	2.0	1.7
Pavlov. Cond. lever latency	1.5	2.0	2.2	-1.4	-1.4	1.5	-1.4	-1.4
Pavlov. Cond. magazine entry latency	0.2	0.2	0.2	0.5	0.5	-0.4	0.4	0.5
Pavlov. Cond. change in total contacts	0.5	0.7	0.9	1.0	0.6	-0.8	0.9	0.6
Pavlov. Cond. index score	0.7	0.9	1.1	1.0	0.8	-1.0	1.0	0.8
Pavlov. Cond. latency score	0.6	0.8	0.9	0.9	0.8	-0.9	0.9	0.8
Pavlov. Cond. lever contacts	0.7	0.9	1.1	1.0	0.9	-1.0	1.0	0.9
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.5	-0.3	0.2	-0.2	-0.3
Pavlov. Cond. intertrial magazine entries	2.5	3.2	3.4	-1.8	-1.7	1.8	-1.8	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.7	0.8	0.6	-0.7	0.8	0.6
Pavlov. Cond. response bias	1.4	2.0	2.2	1.5	1.3	-1.5	1.5	1.3
Conditioned reinforcement - actives	0.2	0.2	0.3	0.4	0.4	-0.4	0.5	0.4
Conditioned reinforcement - inactives	1.7	1.9	2.2	1.2	1.5	-1.4	1.3	1.5
Conditioned locomotion	0.1	0.1	0.3	-0.3	-0.5	0.4	-0.2	-0.5
Intermittent access intake day 1-15 change	0.0	0.0	0.1	0.2	-0.2	0.1	0.1	-0.3
Intermittent access intake escalation	0.2	0.2	0.3	-0.1	-0.5	0.4	-0.2	-0.5
Intermittent access intake escalation 2	0.8	0.8	1.2	-0.7	-1.1	0.9	-0.7	-1.0
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.2	-0.0
Intermitt. access day 15 inactive lever presses	4.0	4.4	5.0	2.1	2.2	-2.1	1.9	2.2
Intermitt. access escalation Index	0.7	0.6	1.2	-1.0	-0.4	0.7	-1.1	-0.4
Intermittent access day 1 total infusions	4.2	4.7	6.1	1.8	2.4	-2.3	1.9	2.5
Intermittent access day 15 total infusions	1.4	1.5	1.7	1.2	1.2	-1.2	1.2	1.3
Intermittent access terminal intake (last 3 days)	1.2	1.3	1.4	1.1	1.2	-1.1	1.1	1.2
Intermittent access total infusions	1.4	1.6	1.8	1.2	1.2	-1.3	1.3	1.3
Intermittent access day 1 locomotion	2.4	2.4	3.0	1.3	1.7	-1.6	1.5	1.7
Intermittent access day 15 total locomotion	0.3	0.3	0.4	0.5	0.6	-0.6	0.7	0.5
Intermittent access total locomotion	0.1	0.1	0.2	0.2	0.4	-0.4	0.4	0.4
Intermittent access standard deviation	0.0	0.0	0.0	-0.0	-0.2	0.1	-0.1	-0.2
Cocaine induced anxiety	0.0	0.1	0.1	0.1	0.3	-0.2	0.2	0.3
Post-drug Anxiety	0.7	0.8	0.9	-0.9	-1.0	0.8	-0.9	-1.0
Baseline Anxiety	0.5	0.5	0.7	-0.5	-0.9	0.7	-0.7	-0.9
Lifetime Intake	1.6	1.8	2.2	1.1	1.4	-1.4	1.3	1.5
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.3	-0.3	0.3	0.1	-0.4
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.1	-0.6
Progressive ratio test 1 active lever presses	0.3	0.3	0.5	0.4	0.6	-0.6	0.4	0.7
Progressive ratio test 1 breakpoint	0.3	0.3	0.4	0.4	0.6	-0.5	0.4	0.6
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.5	0.7	1.2	-1.0	0.7	1.2
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.2	-0.2	0.2	0.1	-0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	-0.1	0.1	0.2	-0.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.8	0.6	0.9	-0.8	0.7	0.9
Total sessions with >9 infusions	0.6	0.7	1.2	0.4	1.0	-0.8	0.5	1.1
Short access day 1 total inactive lever presses	2.8	3.2	4.4	1.4	2.1	-1.8	1.4	2.1
Short access day 10 total inactive lever presses	0.3	0.4	0.4	0.6	0.7	-0.6	0.5	0.7
Short access day 1 total infusions	1.5	1.6	2.7	0.7	1.6	-1.4	0.7	1.6
Short access day 10 total infusions	2.9	3.2	3.5	1.5	1.9	-1.9	1.7	1.8
Short access total infusions	1.0	1.1	1.6	0.7	1.2	-1.1	0.7	1.3
Short access day 1 locomotion	4.3	4.5	5.4	2.0	2.2	-2.1	1.9	2.3
Short access day 10 total locomotion	1.0	1.0	1.2	0.9	1.0	-1.0	1.1	1.1
Short access total locomotion	0.2	0.2	0.3	0.2	0.5	-0.5	0.3	0.6
Compulsive drug intake	0.3	0.3	0.7	-0.8	-0.4	0.4	-0.5	-0.5
One hour access (0.3 mA shock)	0.9	1.1	1.4	0.8	1.0	-1.1	1.2	1.1
One hour access (shock baseline)	1.1	1.3	1.6	1.2	1.0	-1.1	1.2	1.2
Number of responses in last shaping day	0.0	0.0	0.1	0.2	0.1	-0.1	0.3	0.2
Context. condit. distance diff. score	0.1	0.1	0.3	-0.4	-0.5	0.3	-0.2	-0.4
Locomotion velocity, session 1	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.4	-0.2
Locomotion distance, session 1	2.1	2.8	3.2	1.6	1.7	-1.7	1.5	1.8
Locomotion velocity, session 2	0.2	0.2	0.3	-0.3	-0.5	0.4	-0.3	-0.5
Locomotion distance, session 2	0.0	0.0	0.0	0.1	0.1	0.0	-0.1	0.1
Locomotion velocity, session 3	0.3	0.4	0.5	0.4	0.7	-0.6	0.7	0.6
Locomotion distance, session 3	1.0	1.1	1.2	1.1	1.1	-1.0	0.9	1.1
Stereotopy head waving bouts, day 3	1.0	1.2	1.7	1.1	0.9	-1.1	1.3	1.0
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.3	0.0
Locomotion velocity, session 7	0.6	0.6	0.9	0.9	0.8	-0.8	0.8	0.7
Locomotion distance, session 7	0.0	0.1	0.1	-0.1	-0.3	0.2	-0.1	-0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	0.1
Stereotopy head waving duration, day 7	0.6	0.7	1.0	0.8	0.9	-0.8	0.7	1.0
Locomotion velocity, session 8	0.0	0.0	0.1	-0.3	-0.0	0.0	-0.0	-0.1
Locomotion distance, session 8	0.2	0.2	0.5	0.7	0.2	-0.4	0.5	0.4
Degree of sensitization distance	1.3	1.4	1.7	-1.1	-1.2	1.2	-1.0	-1.3
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.0	0.1	0.1	-0.2	0.1
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	-0.4	-0.5	0.6	-0.5	-0.7
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.4	-0.4	0.6	-0.5	-0.6
Condit. Reinf. active responses	0.5	0.6	0.8	0.9	0.8	-0.7	0.7	0.7
Condit. Reinf. inactive responses	1.8	2.1	2.4	1.4	1.4	-1.5	1.4	1.6
Incentive salience index mean	0.2	0.2	0.4	0.6	0.5	-0.4	0.4	0.2
Condit. Reinf. lever presses	1.1	1.5	1.9	1.4	1.3	-1.2	1.1	1.2
Time in familiar zone, hab. session 1	0.8	0.7	1.0	-0.9	-0.7	0.9	-1.0	-0.8
Time in novel zone, hab. session 1	0.6	0.6	0.7	-0.8	-0.7	0.8	-0.8	-0.7
Total zone transitions, hab. session 1	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	0.4
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.2	0.3	-0.2	0.3	0.2
Locomotion velocity, hab. session 1	0.8	1.2	1.3	1.2	1.1	-1.1	1.2	1.0
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.1	0.1	0.0	-0.1	0.1
Time in novel zone, hab. session 2	0.5	0.5	0.7	-0.8	-0.7	0.6	-0.6	-0.7
Total zone transitions, hab. session 2	0.2	0.2	0.4	0.6	0.4	-0.4	0.5	0.4
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.6	0.4	-0.5	0.6	0.3
Locomotion velocity, hab. session 2	0.4	0.6	0.8	0.9	0.7	-0.8	0.9	0.6
Novel to familiar place preference ratio	0.4	0.4	0.5	-0.6	-0.6	0.7	-0.7	-0.6
Novelty place preference	0.8	0.8	0.9	-0.8	-0.9	1.0	-1.0	-0.9
Time in novel zone, NPP test	1.1	1.1	1.2	-1.0	-1.0	1.1	-1.1	-1.1
Total zone transitions, NPP test	1.5	2.2	2.6	1.6	1.3	-1.5	1.5	1.4
Total locomotion distance, NPP test	1.7	2.4	2.8	1.7	1.4	-1.5	1.7	1.4
Locomotion velocity, NPP test	3.3	4.8	5.4	2.3	2.1	-2.2	2.3	2.1
Pavlov. Cond. lever latency	1.5	2.0	2.8	-1.7	-1.2	1.4	-1.4	-1.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.0	-0.1	0.1	-0.0
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.4	-0.1	-0.1	0.2	-0.0
Pavlov. Cond. index score	0.6	0.8	1.3	1.2	0.7	-0.9	0.9	0.7
Pavlov. Cond. latency score	0.5	0.7	1.2	1.1	0.6	-0.8	0.9	0.6
Pavlov. Cond. lever contacts	1.1	1.3	1.9	1.4	1.0	-1.1	1.2	0.9
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	-0.7	-0.4	0.6	-0.7	-0.4
Pavlov. Cond. intertrial magazine entries	1.5	1.8	2.1	1.3	1.4	-1.4	1.2	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.7	1.7	1.2	-1.4	1.4	1.2
Pavlov. Cond. response bias	1.2	1.5	2.1	1.5	1.1	-1.2	1.3	1.0
Bone: apparent density	5.3	8.8	9.4	2.8	3.1	-3.0	2.8	3.1
Bone surface	1.9	3.4	3.8	1.9	1.7	-1.9	1.9	1.7
Bone volume	2.3	4.0	4.3	1.9	2.0	-2.1	2.0	2.0
Bone: connectivity density	5.2	8.1	8.6	2.8	2.9	-2.9	2.7	2.9
Bone: cortical apparent density	0.5	0.6	0.8	0.9	0.7	-0.8	0.8	0.8
Bone: cortical area	0.4	0.6	0.9	0.9	0.7	-0.8	0.7	0.7
Bone: cortical porosity	1.1	1.2	1.2	1.1	1.1	-1.1	1.0	1.1
Bone: cortical porosity	1.0	1.0	1.1	1.0	1.1	-1.0	0.9	1.1
Bone: cortical thickness	0.0	0.0	0.0	0.2	0.1	-0.0	-0.2	0.1
Bone: cortical thickness	1.5	1.8	2.1	1.4	1.3	-1.3	1.3	1.3
Bone: cortical tissue density	0.3	0.4	0.6	0.8	0.6	-0.7	0.6	0.6
Bone: elastic displacement	1.0	1.1	1.3	1.0	1.1	-1.1	0.9	1.1
Bone: elastic work	1.2	1.6	1.7	1.3	1.3	-1.3	1.1	1.3
Bone: endosteal estimation	0.2	0.3	0.7	0.6	0.3	-0.6	0.8	0.3
Bone: endosteal perimeter	0.0	0.1	0.2	0.3	0.1	-0.4	0.4	0.1
Bone: final force	0.1	0.2	0.4	0.6	0.4	-0.4	0.3	0.4
Bone: final moment	0.1	0.2	0.4	0.6	0.4	-0.4	0.3	0.4
Bone: marrow area	0.2	0.4	0.8	0.6	0.4	-0.7	0.9	0.4
Bone: maximum diameter	0.9	1.6	1.9	1.4	1.2	-1.3	1.3	1.2
Bone: maximum force	0.0	0.0	0.1	0.3	0.1	-0.1	-0.0	0.1
Bone: maximum moment	0.0	0.0	0.1	0.3	0.2	-0.2	0.1	0.2
Bone: minimum diameter	0.1	0.2	0.3	-0.3	-0.5	0.4	-0.4	-0.5
Bone: periosteal estimation	0.4	0.8	1.1	1.0	0.7	-1.0	1.0	0.8
Bone: periosteal perimeter	0.1	0.2	0.3	0.6	0.3	-0.5	0.5	0.3
Bone: post-yield work	0.4	0.6	0.6	0.8	0.8	-0.7	0.7	0.8
Bone: stiffness	0.0	0.1	0.1	0.0	-0.4	0.3	-0.2	-0.4
Bone: tissue strength	0.3	0.3	0.6	-0.7	-0.4	0.6	-0.8	-0.4
Bone: trabecular number	4.4	6.8	7.6	2.5	2.7	-2.6	2.4	2.7
Bone: trabecular spacing	1.9	2.5	2.8	-1.5	-1.5	1.7	-1.7	-1.5
Bone: trabecular thickness	0.5	0.6	0.7	0.6	0.8	-0.8	0.8	0.8
Bone: trabecular tissue density	0.1	0.1	0.2	0.3	0.0	-0.2	0.5	0.0
Breakpoint value in progressive ratio session	0.7	0.7	1.0	0.7	1.0	-0.9	0.7	1.0
Distance traveled before self-admin	0.1	0.1	0.2	0.3	0.1	-0.2	0.4	0.1
Distance traveled after self-admin	0.4	0.4	0.6	-0.7	-0.6	0.6	-0.6	-0.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.1	-0.3	0.2	-0.3	-0.2
Delta time in open arm before/after self-admin	0.7	0.7	1.1	0.6	1.1	-0.9	0.6	1.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.1	0.4	-0.4	0.2	0.5
Extinction: sum of active levers before priming	0.9	0.9	1.1	1.1	0.9	-1.0	1.0	0.9
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.3	0.1	-0.0	-0.2	0.1
Delta distance traveled before/after self-admin	1.8	1.9	2.5	-1.6	-1.3	1.3	-1.5	-1.3
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	-0.9	-0.5	0.6	-0.8	-0.5
Time in closed arm before self-admin	0.4	0.4	0.6	-0.7	-0.6	0.8	-0.6	-0.6
Time in closed arm after self-admin	1.4	1.5	1.6	-1.2	-1.3	1.2	-1.1	-1.2
Time in open arm before self-admin	0.1	0.1	0.2	0.4	0.1	-0.3	0.3	0.1
Time in open arm after self-admin	2.6	2.8	3.3	1.5	1.8	-1.8	1.4	1.8
Sum of active levers in priming session hrs 5-6	1.2	1.2	1.5	1.1	1.0	-1.1	1.2	1.0
Time to tail flick, vehicle, before self-admin	1.6	1.6	2.0	-1.0	-1.4	1.4	-1.1	-1.4
Time to tail flick, vehicle, after self-admin	2.8	3.0	3.8	-1.7	-1.6	1.9	-1.7	-1.6
Time to tail flick, test, before self-admin	0.6	0.5	0.8	0.7	0.9	-0.8	0.5	0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.1	-0.4	0.3	-0.1	-0.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	0.1	0.3	-0.1	-0.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.7	0.7	0.2	-0.4	0.8	0.3
Ambulatory time before self-admin	0.3	0.3	0.5	0.6	0.3	-0.5	0.7	0.3
Ambulatory time after self-admin	0.2	0.2	0.3	-0.6	-0.4	0.5	-0.4	-0.5
Total heroin consumption	2.7	3.3	3.9	1.7	2.0	-1.8	1.7	1.9
Area under the delay curve	1.2	1.3	1.4	1.1	1.1	-1.2	1.2	1.1
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.6	-0.6	0.6	-0.5	-0.6
Delay disc. indifference point, 16s delay	1.4	1.4	1.6	1.0	1.3	-1.3	1.2	1.3
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Delay disc. indifference point, 24s delay	5.6	5.4	5.8	2.4	2.3	-2.3	2.4	2.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.2	0.3	0.5	-0.4	0.4	0.5
Delay disc. indifference point, 8s delay	1.1	1.2	1.3	1.0	1.1	-1.1	1.1	1.1
Delay discount exponential model param	1.9	2.0	2.2	-1.4	-1.4	1.4	-1.5	-1.3
Delay discount hyperbolic model param	1.6	1.7	1.9	-1.3	-1.3	1.3	-1.4	-1.3
Fecal boli incidents, locomotor time 1	0.5	0.6	0.8	0.8	0.6	-0.9	0.9	0.6
Change in fecal boli incidents, locomotor task	4.0	3.8	4.3	-2.1	-1.8	2.0	-2.0	-1.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.4	0.3	-0.3	0.4	0.3
Bouts of movement, locomotor time 1	4.5	5.0	6.2	2.3	2.1	-2.2	2.5	2.1
Total resting periods, locomotor time 1	4.3	4.8	6.1	2.3	2.0	-2.1	2.5	2.0
Rest time, locomotor task time 1	0.0	0.0	0.1	0.3	-0.1	-0.1	0.3	-0.1
Distance moved, locomotor task time 1	0.8	0.9	1.5	-1.1	-0.6	0.9	-1.2	-0.6
Vertical activity count, locomotor time 1	0.3	0.3	0.4	-0.7	-0.5	0.6	-0.6	-0.5
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.0	0.1	-0.0	0.0	0.1
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.0	-0.4	0.2	0.1	-0.4
Total resting periods, locomotor time 2	0.1	0.1	0.1	0.2	-0.3	0.1	0.3	-0.3
Rest time, locomotor task time 2	1.6	1.9	2.5	1.6	1.1	-1.4	1.6	1.1
Distance moved, locomotor task time 2	1.1	1.3	1.9	-1.3	-0.9	1.1	-1.4	-0.9
Vertical activity count, locomotor time 2	1.0	1.1	1.3	-1.1	-1.0	1.1	-1.1	-1.0
Weight adjusted by age	0.2	0.2	0.4	-0.3	-0.4	0.5	-0.6	-0.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.4	0.7	-0.8	-0.6	0.6	-0.8	-0.5
Locomotion in novel chamber	1.3	1.6	1.8	-1.3	-1.3	1.2	-1.3	-1.2
Locomotion in novel chamber post-restriction	1.8	2.1	2.2	-1.5	-1.4	1.5	-1.5	-1.4
Progressive ratio	0.7	0.8	1.0	-0.9	-1.0	0.8	-0.9	-0.9
Food seeking constrained by brief footshock	2.6	3.1	3.4	1.8	1.8	-1.7	1.7	1.8
Seeking ratio, punishment vs. effort	1.9	2.3	2.6	1.6	1.6	-1.4	1.5	1.5
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.2	-0.2	-0.0	0.2	-0.2
Run reversals in cocaine runway, males	0.7	0.7	1.0	1.0	0.6	-0.8	0.7	0.9
Latency to leave start box in cocaine runway	0.4	0.4	0.9	0.5	0.9	-0.6	0.5	0.7
Latency to leave start box in cocaine runway, F	0.5	0.6	0.9	0.7	0.9	-0.7	0.6	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.2	0.3	-0.2	0.4	0.2
Cd content in liver	0.0	0.1	0.1	0.2	0.3	-0.2	0.2	0.3
Co content in liver	7.6	9.0	9.7	2.8	3.1	-3.0	3.0	3.1
Cu content in liver	0.1	0.2	0.2	0.4	0.5	-0.3	0.4	0.5
Fe content in liver	0.1	0.1	0.1	-0.2	-0.4	0.3	-0.4	-0.4
K content in liver	0.4	0.4	0.6	-0.5	-0.8	0.6	-0.3	-0.8
Mg content in liver	0.3	0.4	0.5	-0.5	-0.7	0.6	-0.4	-0.7
Mn content in liver	0.3	0.3	0.4	0.7	0.5	-0.6	0.6	0.5
Na content in liver	0.1	0.1	0.3	0.5	0.2	-0.3	0.4	0.2
Rb content in liver	0.0	0.0	0.0	-0.2	-0.2	0.1	0.0	-0.2
Se content in liver	0.6	0.7	0.8	-0.9	-0.8	0.8	-0.9	-0.8
Sr content in liver	0.1	0.1	0.2	-0.2	-0.4	0.3	-0.1	-0.4
Zn content in liver	0.4	0.5	1.0	-0.9	-0.3	0.8	-1.0	-0.3