Hub : Genes

Polr3h

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000004471	0.13	0.07	6.4e-15	0.1	0.1	0.09	0.09	7.1e-11	9.6e-11	3.7e-10	2.4e-10
2	BLA	intron excision ratio	chr7:113439450:113439717	0.08	0.05	2.1e-03	0.03	0.05	0.04	0.04	7.7e-03	1.1e-03	5.1e-03	5.5e-03
3	BLA	intron excision ratio	chr7:113449412:113451873	0.06	0.04	1.4e-03	0.03	0.05	0.04	0.03	6.5e-03	1.4e-03	4.4e-03	6.5e-03
4	Brain	gene expression	ENSRNOG00000004471	0.11	0.05	8.3e-14	0.15	0.14	0.14	0.15	4.5e-14	4.2e-13	2.4e-13	1.1e-13
5	Brain	intron excision ratio	chr7:113439450:113439717	0.03	0.02	4.8e-03	0.01	0.01	0	0	4.7e-02	2.4e-02	1.8e-01	1.1e-01
6	Liver	gene expression	ENSRNOG00000004471	0.06	0.04	4.0e-06	0.03	0.03	0.03	0.03	1.1e-04	1.2e-04	5.0e-04	3.0e-04
7	PL	gene expression	ENSRNOG00000004471	0.07	0.04	2.8e-04	0.04	0.04	0.03	0.03	8.5e-04	6.8e-04	2.8e-03	2.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
BMI with tail	1.7	5.4	7.4	1.9	2.6	-2.5	-2.3	2.2	2.0	-2.7
BMI without tail	0.0	0.1	0.2	-0.3	0.3	-0.1	-0.1	0.4	-0.2	-0.4
Body weight	1.6	7.0	8.8	2.8	2.1	-2.4	-2.6	2.6	3.0	-2.8
Epididymis fat weight	3.1	7.2	12.1	3.1	0.8	-1.8	-2.9	3.5	3.3	-2.4
Glucose	0.3	0.4	0.8	-0.9	0.0	0.4	0.8	-0.6	-0.9	0.3
Heart weight	2.9	4.1	6.2	1.3	2.5	-2.4	-2.0	1.8	1.3	-2.5
Left kidney weight	11.9	34.1	39.3	6.1	4.6	-5.7	-6.2	5.7	6.3	-6.1
Right kidney weight	13.0	37.1	41.9	6.2	5.2	-6.1	-6.5	5.8	6.3	-6.4
Tail length	0.2	0.7	1.3	-0.7	-1.1	1.1	0.8	-0.5	-0.6	0.9
Length with tail	0.3	1.0	2.3	1.4	0.2	-0.6	-1.0	1.0	1.5	-0.8
Length without tail	1.4	3.0	5.0	2.2	1.3	-1.6	-1.7	1.3	2.2	-1.5
Liver weight, left	0.6	0.9	2.0	1.1	-0.3	-0.2	-1.1	1.4	1.2	-0.7
Liver weight, right	2.0	3.3	7.1	2.2	-0.1	-0.8	-1.9	2.7	2.2	-1.4
Parametrial fat weight	0.2	0.3	0.4	0.6	0.6	-0.7	-0.4	0.6	0.5	-0.6
Retroperitoneal fat weight	4.2	13.8	21.2	4.4	2.2	-3.1	-3.7	4.1	4.6	-3.5
Intraocular pressure	0.3	0.4	0.9	0.8	-0.2	-0.2	-0.9	0.8	0.8	-0.3
Extensor digitorum longus weight	0.2	0.8	1.3	-1.1	-0.5	0.8	1.0	-0.7	-1.1	0.7
Soleus weight	0.2	0.4	1.2	-0.7	0.3	0.0	0.6	-1.1	-0.9	0.4
Tibialis anterior weight	0.5	1.6	2.5	-1.5	-0.2	0.7	1.5	-1.6	-1.6	1.1
Tibia length	0.8	2.2	2.9	1.7	1.2	-1.5	-1.6	1.0	1.7	-1.5
Number of licking bursts	0.6	0.7	1.1	-1.0	-0.6	0.7	0.7	-1.0	-0.9	0.9
Food consumed during 24 hour testing period	1.9	2.3	2.7	1.6	1.6	-1.6	-1.4	1.2	1.6	-1.6
Times rat made contact with spout	0.7	0.8	1.2	0.8	1.1	-1.1	-0.9	0.5	0.8	-0.9
Mean time between licks in bursts	0.4	0.6	1.0	-1.0	-0.5	0.7	0.8	-0.7	-0.9	0.7
Mean num. licks in bursts	2.0	2.4	3.1	1.8	1.2	-1.4	-1.6	1.6	1.7	-1.5
Std. dev. time between licks in bursts	1.2	1.4	2.9	-1.4	0.0	0.6	1.3	-1.7	-1.5	0.8
Water consumed over 24 hours	0.6	0.7	0.9	0.8	0.9	-0.9	-0.8	0.5	0.9	-0.9
Indifference point 0 sec	0.4	0.6	1.3	-0.9	0.4	0.1	0.9	-1.1	-1.1	0.3
Indifference point AUC	0.2	0.2	0.6	-0.4	-0.4	0.3	0.3	-0.8	-0.2	0.6
Indifference point function ln k	0.9	1.3	1.9	1.2	0.9	-1.0	-1.0	1.4	1.1	-1.3
Indifference point function log k	0.9	1.3	1.9	1.2	0.9	-1.0	-1.0	1.4	1.1	-1.3
Delay discounting total patch changes 0 sec	0.5	0.7	1.5	-1.0	0.3	0.3	1.0	-1.2	-1.2	0.4
Delay discounting total patch changes 12 sec	0.1	0.1	0.3	-0.1	0.6	-0.4	0.2	-0.4	-0.2	-0.2
Delay discounting total patch changes 18 sec	0.2	0.3	0.6	-0.6	0.7	-0.3	0.2	-0.8	-0.5	-0.1
Delay discounting total patch changes 24 sec	0.3	0.3	0.6	-0.7	-0.3	0.4	0.5	-0.7	-0.7	0.6
Delay discounting total patch changes 6 sec	0.4	0.6	1.7	-0.8	0.6	-0.1	0.8	-1.3	-0.9	0.2
Delay discounting time to switch 0 sec	0.0	0.0	0.1	-0.0	-0.3	0.3	0.2	0.3	0.0	-0.0
Delay discounting water rate 0 sec	0.2	0.3	0.8	-0.5	0.5	-0.2	0.6	-0.9	-0.6	0.2
Delay discounting water rate 12 sec	0.4	0.6	1.0	-1.0	-0.5	0.6	0.6	-0.9	-1.0	0.7
Delay discounting water rate 18 sec	1.4	1.8	3.5	-1.2	-0.7	1.1	1.5	-1.9	-1.3	1.3
Delay discounting water rate 24 sec	0.1	0.1	0.5	0.1	0.7	-0.5	0.0	-0.3	-0.0	-0.3
Delay discounting water rate 6 sec	1.3	1.9	2.1	-1.5	-1.3	1.4	1.2	-1.3	-1.4	1.4
Locomotor activity	1.5	2.3	2.9	1.6	0.9	-1.3	-1.7	1.7	1.7	-1.6
Locomotor testing distance	0.0	0.0	0.0	-0.1	-0.2	0.2	0.0	-0.1	-0.2	0.2
Locomotor testing rearing	1.2	2.0	3.2	1.4	0.7	-1.1	-1.7	1.8	1.4	-1.4
Light reinforcement 1	0.0	0.1	0.2	-0.2	-0.4	0.3	-0.3	0.1	-0.4	-0.0
Light reinforcement 2	0.7	1.0	2.0	1.1	0.3	-0.6	-1.1	1.4	1.1	-0.9
Reaction time number correct	1.5	2.1	4.3	-1.0	-2.1	1.8	1.1	-1.1	-0.9	1.8
Reaction time mean minus median	0.1	0.1	0.4	0.0	-0.1	0.0	-0.2	0.6	0.0	-0.3
Reaction time mean minus median AUC	0.5	0.7	1.8	0.8	0.2	-0.5	-0.9	1.4	0.7	-0.8
Reaction time num false alarms	0.2	0.3	0.9	-0.3	-0.9	0.8	0.2	0.2	-0.5	0.4
Reaction time num false alarms AUC	0.3	0.5	1.2	-0.6	-1.1	0.9	0.3	0.0	-0.7	0.6
Reaction time trials correct on left	1.5	2.1	4.3	-1.0	-2.1	1.8	1.1	-1.1	-0.9	1.8
Reaction time trials on left	1.6	2.3	4.6	-1.1	-2.1	1.9	1.1	-1.1	-1.0	1.9
Reaction time mean	0.1	0.1	0.2	-0.5	-0.1	0.3	0.4	-0.2	-0.4	0.2
Reaction time mean AUC	0.1	0.1	0.2	-0.4	-0.2	0.3	0.3	-0.2	-0.4	0.2
Median of all reaction times	0.2	0.2	0.5	-0.7	-0.2	0.4	0.6	-0.5	-0.5	0.4
Reaction time omissions	0.4	0.6	0.9	-0.8	-0.9	0.9	0.5	-0.4	-0.7	0.8
Reaction time false alarm rate	0.1	0.1	0.4	0.0	0.1	-0.1	-0.3	0.6	-0.1	-0.4
Reaction time premature initiation rate	0.2	0.3	0.9	-0.4	0.8	-0.3	0.6	-0.9	-0.3	-0.1
Reaction time premature initiations	0.3	0.4	1.3	-0.6	-0.1	0.4	0.8	-1.1	-0.5	0.6
Std. dev. reaction times	0.2	0.3	0.8	0.2	0.2	-0.4	-0.7	0.9	0.2	-0.6
Reaction time trials completed	1.6	2.3	4.6	-1.1	-2.1	1.9	1.1	-1.1	-1.0	1.9
Reaction time trials AUC	1.2	1.7	3.7	-0.8	-1.9	1.7	1.0	-1.0	-0.7	1.6
Social response proportion	0.4	0.4	1.3	0.1	1.2	-0.8	-0.1	0.3	0.1	-0.9
Social responses	0.1	0.1	0.2	-0.3	-0.4	0.4	0.3	-0.3	-0.4	0.4
Social time	1.6	2.1	3.6	-1.9	-0.7	1.2	1.5	-1.6	-1.7	1.4
Conditioned locomotion	0.4	0.5	1.3	0.7	-0.2	-0.2	-0.8	1.2	0.8	-0.5
Cocaine response after cond. corrected	0.0	0.0	0.1	0.3	-0.2	0.1	-0.1	0.2	0.3	-0.0
Cocaine response after cond. not corrected	0.0	0.0	0.1	0.0	-0.3	0.2	0.2	0.2	0.0	0.0
Cocaine response before conditioning	0.2	0.2	0.5	-0.7	-0.1	0.3	0.5	-0.2	-0.7	0.2
Saline control response	0.2	0.2	0.6	-0.4	-0.8	0.6	0.3	0.4	-0.4	0.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.8	-0.0	0.9	-0.7	-0.2	-0.6	-0.0	-0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.6	0.3	1.3	-1.0	-0.4	-0.4	0.3	-0.6
Condit. Reinf. active responses	0.4	0.6	0.9	0.7	0.9	-1.0	-0.9	0.2	0.6	-0.8
Condit. Reinf. inactive responses	0.6	0.7	1.2	0.9	0.4	-0.7	-1.1	0.9	0.8	-0.8
Condit. Reinf. lever presses	0.3	0.4	1.0	-0.7	0.3	0.0	0.7	-1.0	-0.7	0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.7	0.4	0.9	-0.8	-0.6	-0.1	0.3	-0.6
Pavlov. Cond. lever latency	0.9	1.3	2.6	1.5	-0.1	-0.5	-1.4	1.6	1.3	-0.6
Pavlov. Cond. magazine entry latency	2.7	3.1	7.0	-2.0	0.0	0.8	2.1	-2.6	-1.9	1.4
Pavlov. Cond. change in total contacts	0.8	1.1	2.8	-0.8	1.6	-0.7	0.8	-1.7	-0.7	-0.3
Pavlov. Cond. index score	1.8	2.4	5.6	-1.8	0.2	0.6	1.9	-2.4	-1.7	1.1
Pavlov. Cond. latency score	2.3	2.8	6.6	-2.0	0.3	0.6	2.0	-2.6	-1.8	1.2
Pavlov. Cond. lever contacts	0.8	1.2	2.4	-1.4	0.4	0.3	1.3	-1.6	-1.3	0.5
Pavlov. Cond. magazine entry number	1.3	1.6	4.3	1.4	-0.3	-0.3	-1.5	2.1	1.2	-0.9
Pavlov. Cond. intertrial magazine entries	3.0	3.8	4.5	1.9	1.8	-2.0	-2.1	2.0	1.8	-2.0
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	5.4	-1.9	0.1	0.7	1.9	-2.3	-1.7	1.1
Pavlov. Cond. response bias	0.9	1.2	3.1	-1.4	0.6	0.1	1.3	-1.8	-1.2	0.5
Conditioned reinforcement - actives	0.2	0.2	0.7	0.3	0.1	-0.3	-0.8	0.4	0.4	-0.3
Conditioned reinforcement - inactives	0.3	0.4	0.9	-0.9	0.8	-0.4	-0.0	-0.6	-0.7	-0.2
Conditioned locomotion	2.1	2.5	3.6	1.5	1.6	-1.7	-1.9	1.2	1.3	-1.7
Intermittent access intake day 1-15 change	0.4	0.4	1.0	-1.0	-0.3	0.5	0.5	-0.7	-0.7	0.6
Intermittent access intake escalation	0.5	0.5	1.1	-1.1	-0.3	0.5	0.6	-0.7	-0.7	0.6
Intermittent access intake escalation 2	0.2	0.2	0.6	-0.8	-0.3	0.4	0.4	-0.4	-0.5	0.4
Intermitt. access day 1 inactive lever presses	0.8	0.9	2.9	0.3	1.7	-1.3	-0.6	0.1	0.3	-1.1
Intermitt. access day 15 inactive lever presses	1.3	1.5	4.5	0.2	2.1	-1.8	-0.9	0.2	0.2	-1.3
Intermitt. access escalation Index	0.1	0.1	0.5	-0.2	0.7	-0.4	-0.1	-0.4	-0.1	-0.3
Intermittent access day 1 total infusions	1.1	1.2	1.9	1.0	1.1	-1.2	-1.4	0.9	0.9	-1.2
Intermittent access day 15 total infusions	0.1	0.1	0.3	-0.4	0.6	-0.4	-0.3	-0.3	-0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.0	0.1	-0.2	-0.5	0.2	0.2	-0.2
Intermittent access total infusions	0.4	0.4	0.6	0.5	0.7	-0.7	-0.8	0.4	0.6	-0.7
Intermittent access day 1 locomotion	0.6	0.6	0.9	0.7	1.0	-0.9	-0.9	0.6	0.3	-0.9
Intermittent access day 15 total locomotion	0.2	0.2	0.3	0.5	0.4	-0.4	-0.5	0.3	0.4	-0.4
Intermittent access total locomotion	0.7	0.8	1.1	0.9	1.0	-1.0	-1.0	0.6	0.8	-0.9
Intermittent access standard deviation	0.9	1.0	1.6	0.5	1.3	-1.2	-1.1	0.8	0.6	-1.2
Cocaine induced anxiety	1.7	1.9	2.6	1.6	1.5	-1.5	-1.0	1.0	1.6	-1.4
Post-drug Anxiety	0.5	0.6	1.1	0.8	1.0	-0.9	-0.5	0.2	0.8	-0.8
Baseline Anxiety	1.9	2.0	2.5	-1.6	-1.4	1.4	1.3	-1.2	-1.6	1.4
Lifetime Intake	1.3	1.5	2.4	0.9	1.6	-1.5	-1.3	0.7	1.0	-1.3
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.7	0.4	-0.2	0.3	-0.7	-0.4	0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	-0.5	0.6	-0.4	0.1	-0.6	-0.2	0.0
Progressive ratio test 1 active lever presses	0.9	0.9	1.2	0.9	1.1	-1.1	-1.0	0.6	0.9	-0.9
Progressive ratio test 1 breakpoint	0.5	0.6	0.7	0.9	0.7	-0.8	-0.8	0.5	0.9	-0.6
Progressive ratio test 1 inactive lever presses	1.2	1.3	3.7	0.3	1.9	-1.5	-0.8	0.5	0.4	-1.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	0.1	0.6	-0.5	-0.3	-0.3	0.1	-0.1
Progressive ratio test 2 breakpoint	0.3	0.3	0.9	0.3	1.0	-0.8	-0.4	-0.2	0.4	-0.4
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.8	-0.8	0.9	-0.5	0.2	-0.8	-0.8	0.0
Total sessions with >9 infusions	2.5	2.7	3.5	1.5	1.9	-1.9	-1.7	1.1	1.6	-1.8
Short access day 1 total inactive lever presses	1.4	1.5	3.1	0.5	1.8	-1.6	-1.3	0.6	0.6	-1.5
Short access day 10 total inactive lever presses	0.3	0.3	0.6	0.2	0.6	-0.7	-0.8	0.5	0.1	-0.8
Short access day 1 total infusions	2.3	2.5	4.4	0.9	2.1	-1.9	-1.7	1.0	1.0	-1.9
Short access day 10 total infusions	1.5	1.6	2.3	1.5	1.3	-1.3	-1.0	1.0	1.5	-1.2
Short access total infusions	3.8	4.2	6.4	1.7	2.5	-2.4	-2.1	1.4	1.7	-2.3
Short access day 1 locomotion	0.5	0.5	1.3	0.3	1.1	-0.9	-0.6	0.4	0.4	-0.9
Short access day 10 total locomotion	0.2	0.2	0.5	-0.4	0.5	-0.3	-0.2	0.3	-0.7	-0.5
Short access total locomotion	2.1	2.1	3.4	1.1	1.8	-1.6	-1.5	1.2	1.0	-1.7
Compulsive drug intake	2.6	2.5	3.6	-1.4	-1.3	1.4	1.6	-1.9	-1.5	1.8
One hour access (0.3 mA shock)	0.3	0.3	0.6	-0.8	-0.4	0.5	0.3	-0.4	-0.7	0.6
One hour access (shock baseline)	0.2	0.2	0.6	0.3	0.2	-0.3	-0.6	0.8	0.5	-0.4
Number of responses in last shaping day	0.6	0.6	1.2	-0.9	0.9	-0.2	0.8	-1.1	-1.0	0.1
Context. condit. distance diff. score	5.6	6.8	11.2	2.9	1.2	-2.0	-2.9	3.3	2.9	-2.5
Locomotion velocity, session 1	0.2	0.2	0.6	-0.0	-0.8	0.5	0.0	-0.4	-0.0	0.5
Locomotion distance, session 1	2.9	3.7	4.9	-1.7	-1.9	2.0	1.8	-2.1	-1.8	2.2
Locomotion velocity, session 2	0.1	0.1	0.2	0.4	0.2	-0.2	-0.3	0.4	0.4	-0.4
Locomotion distance, session 2	2.2	3.1	6.1	-2.0	-0.5	1.1	1.9	-2.5	-2.0	1.6
Locomotion velocity, session 3	0.2	0.2	0.5	0.5	-0.7	0.3	-0.3	0.5	0.5	0.1
Locomotion distance, session 3	1.7	1.9	3.8	-1.0	-1.9	1.6	1.0	-1.0	-1.0	1.7
Stereotopy head waving bouts, day 3	0.8	0.9	1.3	1.1	0.8	-0.9	-0.9	0.8	1.1	-1.0
Stereotopy head waving duration, day 3	2.8	3.4	4.4	2.0	1.3	-1.6	-1.8	2.0	2.0	-2.1
Locomotion velocity, session 7	0.2	0.2	0.4	0.6	-0.4	0.1	-0.4	0.6	0.6	-0.1
Locomotion distance, session 7	0.0	0.0	0.1	0.1	-0.0	-0.0	0.0	0.0	0.1	0.2
Stereotopy head waving bouts, day 7	1.6	1.8	2.8	1.6	0.0	-0.6	-1.6	1.7	1.7	-1.3
Stereotopy head waving duration, day 7	1.3	1.5	2.9	1.5	-0.2	-0.4	-1.4	1.7	1.5	-1.1
Locomotion velocity, session 8	1.8	2.2	2.7	1.5	1.4	-1.6	-1.6	1.3	1.4	-1.6
Locomotion distance, session 8	0.5	0.8	1.7	0.9	0.3	-0.7	-1.1	1.3	0.9	-0.9
Degree of sensitization distance	3.7	3.7	5.4	1.6	2.3	-2.2	-1.6	1.8	1.6	-2.2
Degree of sensitization stereotypy	1.0	1.1	1.8	1.2	-0.4	-0.2	-1.3	1.4	1.3	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.4	0.3	-0.1	0.4	-0.6	-0.4	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.5	0.3	-0.5	-0.5	0.4	0.5	-0.5
Condit. Reinf. active responses	1.2	1.4	2.4	-1.6	-0.2	0.7	1.4	-1.3	-1.5	0.9
Condit. Reinf. inactive responses	2.6	3.0	4.9	-2.2	-0.9	1.4	1.9	-1.6	-2.2	1.6
Incentive salience index mean	0.3	0.4	0.8	-0.7	0.3	0.1	0.7	-0.9	-0.8	0.4
Condit. Reinf. lever presses	0.5	0.7	1.3	-1.0	-0.1	0.5	1.0	-1.0	-1.1	0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.4	-0.3	0.1	-0.4	0.0	0.3	0.1
Time in novel zone, hab. session 1	0.4	0.4	0.8	0.4	0.5	-0.5	-0.4	0.9	0.5	-0.9
Total zone transitions, hab. session 1	4.1	5.8	7.5	-2.3	-2.4	2.4	2.3	-2.4	-2.3	2.7
Total locomotion distance, hab. session 1	2.7	3.9	6.4	-1.8	-2.5	2.3	1.6	-1.5	-1.7	2.2
Locomotion velocity, hab. session 1	2.9	4.2	5.3	-2.0	-2.3	2.2	1.8	-1.8	-2.0	2.2
Time in familiar zone, hab. session 2	0.4	0.4	1.4	0.1	-1.2	0.8	-0.1	0.5	0.0	0.4
Time in novel zone, hab. session 2	0.3	0.3	1.2	-0.0	1.1	-0.8	0.0	-0.4	0.0	-0.5
Total zone transitions, hab. session 2	0.9	1.2	2.6	-1.3	-0.3	0.6	1.0	-1.6	-1.3	1.0
Total locomotion distance, hab. session 2	0.8	1.1	1.8	-1.3	-0.4	0.7	1.0	-1.3	-1.3	0.9
Locomotion velocity, hab. session 2	1.5	2.0	2.9	-1.7	-0.7	1.1	1.4	-1.7	-1.7	1.3
Novel to familiar place preference ratio	1.7	1.8	2.8	1.5	0.5	-1.0	-1.4	1.5	1.7	-1.3
Novelty place preference	2.4	2.5	4.0	1.9	0.6	-1.2	-1.7	1.9	2.0	-1.5
Time in novel zone, NPP test	3.1	3.3	5.0	2.1	0.7	-1.4	-1.9	2.1	2.2	-1.7
Total zone transitions, NPP test	3.3	4.7	5.7	-2.2	-1.9	2.0	2.0	-2.4	-2.2	2.4
Total locomotion distance, NPP test	1.6	2.2	3.0	-1.6	-1.1	1.3	1.4	-1.7	-1.6	1.5
Locomotion velocity, NPP test	2.5	3.5	4.1	-2.0	-1.6	1.8	1.8	-2.0	-1.9	2.0
Pavlov. Cond. lever latency	0.8	1.0	1.6	1.1	0.3	-0.7	-1.3	1.2	1.2	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.6	1.3	-0.7	0.2	0.3	1.0	-1.1	-0.9	0.7
Pavlov. Cond. change in total contacts	0.9	0.9	2.1	-1.1	0.4	0.2	1.0	-1.5	-1.2	0.6
Pavlov. Cond. index score	0.2	0.3	0.6	-0.4	0.6	-0.2	0.7	-0.8	-0.5	0.2
Pavlov. Cond. latency score	0.2	0.3	0.5	-0.4	0.6	-0.1	0.7	-0.7	-0.6	0.2
Pavlov. Cond. lever contacts	0.9	1.1	1.7	-1.2	-0.2	0.6	1.3	-1.2	-1.3	0.9
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	0.4	-0.2	-0.2	-0.8	0.8	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.1	-1.3	-0.3	0.6	1.1	-1.5	-1.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.8	-0.5	0.3	0.1	0.8	-0.9	-0.7	0.4
Pavlov. Cond. response bias	0.4	0.5	1.0	-0.7	0.2	0.2	1.0	-1.0	-0.8	0.6
Bone: apparent density	0.2	0.3	0.5	-0.6	-0.2	0.4	0.7	-0.7	-0.6	0.5
Bone surface	0.2	0.4	0.7	-0.5	-0.6	0.6	0.6	-0.9	-0.5	0.6
Bone volume	0.0	0.1	0.1	-0.2	-0.3	0.3	0.3	-0.3	-0.2	0.2
Bone: connectivity density	0.1	0.1	0.3	-0.2	-0.0	0.2	0.4	-0.5	-0.2	0.3
Bone: cortical apparent density	0.6	0.7	1.2	-0.9	-0.5	0.7	0.8	-1.1	-0.9	0.9
Bone: cortical area	1.5	2.3	2.8	1.5	1.3	-1.5	-1.7	1.4	1.5	-1.7
Bone: cortical porosity	0.5	0.5	1.0	0.7	0.4	-0.5	-0.5	1.0	0.7	-0.8
Bone: cortical porosity	1.2	1.3	1.8	1.3	0.8	-0.9	-1.0	1.3	1.2	-1.3
Bone: cortical thickness	0.5	0.9	2.2	0.6	1.5	-1.3	-0.8	0.2	0.5	-1.0
Bone: cortical thickness	0.7	0.8	2.0	0.5	1.4	-1.2	-0.9	0.3	0.5	-0.9
Bone: cortical tissue density	0.5	0.7	1.1	-0.9	-0.5	0.6	0.8	-1.1	-0.9	0.9
Bone: elastic displacement	0.1	0.1	0.3	0.0	-0.5	0.3	-0.0	-0.0	0.0	0.2
Bone: elastic work	1.9	2.4	3.2	1.6	1.4	-1.5	-1.6	1.5	1.6	-1.8
Bone: endosteal estimation	0.4	0.8	1.5	1.1	-0.3	-0.2	-0.9	1.2	1.1	-0.8
Bone: endosteal perimeter	1.2	2.4	4.5	1.9	-0.1	-0.6	-1.7	2.1	1.8	-1.4
Bone: final force	2.0	3.4	4.4	1.9	2.1	-2.1	-1.6	1.1	1.9	-1.9
Bone: final moment	2.2	3.6	4.8	1.9	2.2	-2.2	-1.7	1.1	1.9	-2.0
Bone: marrow area	0.4	0.8	1.6	1.1	-0.2	-0.3	-0.9	1.3	1.1	-0.9
Bone: maximum diameter	3.6	6.6	7.9	2.7	1.9	-2.3	-2.8	2.6	2.7	-2.8
Bone: maximum force	3.1	5.5	6.5	2.4	2.5	-2.5	-2.3	1.7	2.3	-2.5
Bone: maximum moment	3.4	5.9	7.1	2.4	2.6	-2.7	-2.4	1.8	2.4	-2.7
Bone: minimum diameter	0.4	0.7	1.3	0.9	0.1	-0.4	-1.0	1.1	0.9	-0.9
Bone: periosteal estimation	1.0	2.1	2.8	1.7	0.6	-1.0	-1.6	1.7	1.6	-1.6
Bone: periosteal perimeter	2.9	4.8	6.9	2.5	0.9	-1.5	-2.5	2.6	2.5	-2.2
Bone: post-yield work	0.4	0.6	1.5	0.4	1.2	-1.0	-0.6	0.1	0.4	-0.9
Bone: stiffness	2.0	3.2	4.1	1.7	2.0	-1.9	-1.8	1.4	1.7	-2.0
Bone: tissue strength	0.1	0.1	0.2	0.4	0.4	-0.4	-0.4	0.1	0.4	-0.4
Bone: trabecular number	0.1	0.1	0.4	0.2	-0.6	0.4	-0.1	0.3	0.3	0.2
Bone: trabecular spacing	1.3	1.7	2.0	1.2	1.4	-1.4	-1.4	0.9	1.3	-1.4
Bone: trabecular thickness	0.1	0.2	0.3	-0.5	-0.3	0.4	0.5	-0.2	-0.5	0.3
Bone: trabecular tissue density	1.2	1.7	3.1	-1.6	-0.0	0.7	1.8	-1.6	-1.6	0.9
Breakpoint value in progressive ratio session	0.1	0.1	0.3	-0.3	0.5	-0.2	0.3	-0.3	-0.4	-0.1
Distance traveled before self-admin	0.3	0.3	1.0	-0.3	1.0	-0.7	-0.2	0.1	-0.3	-0.5
Distance traveled after self-admin	0.4	0.5	1.8	-0.2	1.3	-0.9	-0.3	-0.5	-0.3	-0.7
Delta time in closed arm before/after self-admin	1.7	1.6	1.9	1.2	1.3	-1.4	-1.4	1.1	1.2	-1.3
Delta time in open arm before/after self-admin	0.7	0.6	1.1	-0.8	-1.1	1.0	0.4	-0.3	-1.0	0.7
Diff in mean of infusions in LGA sessions	0.2	0.2	0.6	0.1	-0.1	0.2	0.8	-0.8	0.0	0.5
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.2	0.2	-0.2	0.0	-0.1	-0.1	-0.0
Active lever presses in extinction session 6	0.2	0.2	0.4	0.3	0.6	-0.5	-0.2	0.3	0.2	-0.5
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.4	0.2	-0.3	-0.5	-0.0	0.4	-0.4
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	0.4	0.4	-0.4	-0.5	-0.2	0.4	-0.5
Time in closed arm before self-admin	4.6	5.2	8.0	-2.5	-1.1	2.0	2.8	-2.5	-2.5	2.0
Time in closed arm after self-admin	0.4	0.5	0.7	0.6	0.8	-0.7	-0.5	0.8	0.5	-0.9
Time in open arm before self-admin	0.3	0.3	0.7	0.7	-0.8	0.4	-0.3	0.5	0.7	0.3
Time in open arm after self-admin	0.7	0.8	2.4	-0.5	-1.6	1.2	0.4	-0.2	-0.6	1.0
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.1	0.0	0.1	0.2	-0.1	-0.1	0.1
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.1	-0.4	0.2	0.2	-0.1	0.2	0.2
Time to tail flick, vehicle, after self-admin	2.0	2.1	4.6	-1.0	-2.1	1.9	1.2	-0.7	-1.1	1.6
Time to tail flick, test, before self-admin	0.2	0.2	0.9	0.3	-0.9	0.5	0.1	0.5	0.2	0.4
Time to tail flick, test, after self-admin	1.3	1.3	1.6	-1.3	-1.1	1.2	1.0	-1.1	-1.2	1.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.5	-0.2	0.3	0.3	-0.2	-0.5	0.2
Delta time to tail flick, test, before/after SA	2.6	2.4	3.8	-1.9	-0.8	1.2	1.5	-1.8	-1.8	1.4
Ambulatory time before self-admin	0.3	0.3	0.5	-0.7	0.7	-0.5	-0.3	-0.1	-0.7	-0.2
Ambulatory time after self-admin	0.6	0.7	1.8	-1.1	0.3	0.2	0.5	-1.3	-1.2	0.3
Total heroin consumption	0.1	0.1	0.4	0.5	0.6	-0.5	-0.0	-0.2	0.2	-0.2
Area under the delay curve	0.1	0.2	0.4	-0.6	-0.2	0.3	0.2	-0.5	-0.4	0.5
Delay disc. indifference point, 0s delay	1.0	1.1	1.7	0.8	1.1	-1.0	-0.9	1.3	0.8	-1.3
Delay disc. indifference point, 16s delay	1.5	1.5	2.2	-1.3	-0.9	1.1	1.1	-1.5	-1.2	1.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.1	0.4	-0.4	-0.4	0.4	0.3	-0.3
Delay disc. indifference point, 24s delay	0.3	0.3	0.8	0.0	-0.9	0.6	-0.0	-0.6	0.2	0.8
Delay disc. indifference point, 4s delay	0.2	0.3	0.9	-0.4	1.0	-0.7	-0.1	-0.4	-0.2	-0.3
Delay disc. indifference point, 8s delay	0.7	0.7	1.0	-0.9	-0.7	0.8	0.6	-0.8	-0.8	1.0
Delay discount exponential model param	0.2	0.2	0.5	0.7	0.3	-0.3	-0.3	0.6	0.4	-0.6
Delay discount hyperbolic model param	0.1	0.1	0.3	0.6	0.1	-0.1	-0.1	0.4	0.3	-0.3
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	-0.5	-0.3	0.5	0.7	-0.8	-0.4	0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	0.7	-0.4	-0.1	-0.9	0.4	0.8	-0.2
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	0.8	0.3	-0.3	-0.2	0.2	0.5	-0.3
Bouts of movement, locomotor time 1	0.6	0.6	1.9	1.4	0.0	-0.4	-0.4	0.7	1.3	-0.3
Total resting periods, locomotor time 1	0.4	0.4	1.3	1.1	0.3	-0.4	-0.3	0.4	1.0	-0.2
Rest time, locomotor task time 1	0.7	0.7	1.4	0.7	1.2	-1.0	-0.8	0.6	0.7	-0.9
Distance moved, locomotor task time 1	0.3	0.3	0.9	0.5	-0.0	-0.3	-0.7	0.9	0.7	-0.6
Vertical activity count, locomotor time 1	0.0	0.0	0.0	-0.2	-0.0	0.0	-0.0	0.0	0.0	-0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.2	-0.1	0.3	0.4	-0.5	-0.4	0.2
Bouts of movement, locomotor time 2	0.6	0.6	1.2	0.8	1.1	-1.0	-0.6	0.5	0.5	-0.9
Total resting periods, locomotor time 2	0.5	0.5	1.2	0.7	1.1	-1.0	-0.5	0.3	0.4	-0.8
Rest time, locomotor task time 2	0.1	0.1	0.3	-0.2	0.0	0.1	0.3	-0.5	-0.3	0.3
Distance moved, locomotor task time 2	0.6	0.7	1.8	0.6	0.3	-0.5	-1.0	1.4	0.8	-0.9
Vertical activity count, locomotor time 2	0.3	0.3	0.6	0.5	0.2	-0.4	-0.7	0.8	0.5	-0.6
Weight adjusted by age	0.1	0.2	0.4	0.2	-0.7	0.5	0.2	-0.2	0.5	0.3
Seeking ratio, delayed vs. immediate footshock	2.4	2.8	4.2	-1.6	-0.9	1.4	1.9	-2.1	-1.8	1.7
Locomotion in novel chamber	2.1	2.6	5.0	-2.2	-1.8	1.7	0.4	-0.6	-2.2	1.2
Locomotion in novel chamber post-restriction	1.0	1.2	1.5	-1.1	-1.2	1.2	0.9	-0.8	-1.0	1.2
Progressive ratio	0.1	0.1	0.3	-0.5	0.2	0.0	0.4	-0.4	-0.4	0.1
Food seeking constrained by brief footshock	1.6	1.9	3.1	1.1	1.1	-1.4	-1.7	1.4	1.4	-1.5
Seeking ratio, punishment vs. effort	0.7	0.9	1.5	0.9	0.7	-0.9	-1.2	0.9	0.9	-1.0
Run reversals in cocaine runway, females	1.1	1.1	2.3	-0.7	-1.5	1.4	0.8	-0.6	-0.9	1.2
Run reversals in cocaine runway, males	0.4	0.4	1.0	1.0	-0.5	-0.1	-0.8	0.7	0.6	-0.1
Latency to leave start box in cocaine runway	0.3	0.4	0.7	0.8	0.2	-0.4	-0.4	0.8	0.8	-0.5
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	-0.3	-0.6	0.6	0.7	-0.3	-0.4	0.6
Latency to leave start box in cocaine runway, M	2.9	2.8	3.3	1.8	1.4	-1.6	-1.7	1.7	1.8	-1.7
Cd content in liver	0.6	0.6	1.4	0.7	0.3	-0.5	-0.8	1.2	0.9	-0.7
Co content in liver	0.4	0.5	1.0	0.5	1.0	-0.9	-0.6	0.5	0.5	-0.8
Cu content in liver	3.8	4.6	6.1	-2.5	-1.4	1.9	2.3	-2.3	-2.4	2.1
Fe content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	0.2	-0.1	-0.2
K content in liver	0.6	0.6	1.4	-1.0	0.3	0.2	0.8	-1.2	-0.9	0.4
Mg content in liver	0.9	1.0	2.3	-1.3	0.5	0.1	1.0	-1.5	-1.2	0.5
Mn content in liver	0.1	0.1	0.2	0.3	-0.3	0.0	-0.5	0.4	0.3	-0.1
Na content in liver	2.6	2.8	3.6	-1.9	-1.1	1.5	1.8	-1.7	-1.9	1.7
Rb content in liver	0.0	0.0	0.2	-0.1	0.4	-0.3	-0.0	-0.3	-0.0	-0.1
Se content in liver	1.0	1.2	1.4	-1.1	-1.2	1.2	1.1	-0.9	-0.9	1.2
Sr content in liver	0.9	0.8	1.2	-0.8	-0.9	1.0	0.9	-0.6	-1.0	1.1
Zn content in liver	1.4	1.5	1.6	-1.2	-1.1	1.3	1.3	-1.2	-1.3	1.2