# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | gene expression | ENSRNOG00000004392 | 0.0350 | 0.0270 | 2.2e-03 | 0.014 | 0.023 | 0.022 | 0.019 | 9.0e-03 | 1.3e-03 | 1.4e-03 | 3.2e-03 |
2 | Adipose | mRNA stability | ENSRNOG00000004392 | 0.0580 | 0.0400 | 5.5e-07 | 0.059 | 0.059 | 0.051 | 0.051 | 4.0e-07 | 3.4e-07 | 2.1e-06 | 2.4e-06 |
3 | BLA | gene expression | ENSRNOG00000004392 | 0.2333 | 0.1145 | 2.9e-09 | 0.121 | 0.145 | 0.144 | 0.138 | 5.0e-07 | 3.5e-08 | 3.8e-08 | 8.0e-08 |
4 | BLA | mRNA stability | ENSRNOG00000004392 | 0.2000 | 0.0890 | 9.1e-12 | 0.190 | 0.184 | 0.186 | 0.178 | 1.9e-10 | 4.2e-10 | 3.3e-10 | 8.0e-10 |
5 | Brain | gene expression | ENSRNOG00000004392 | 0.2300 | 0.1000 | 0.0e+00 | 0.180 | 0.222 | 0.238 | 0.233 | 1.9e-16 | 2.4e-20 | 7.4e-22 | 2.2e-21 |
6 | Brain | mRNA stability | ENSRNOG00000004392 | 0.2538 | 0.0967 | 0.0e+00 | 0.299 | 0.313 | 0.307 | 0.303 | 4.3e-28 | 1.4e-29 | 7.6e-29 | 1.7e-28 |
7 | Eye | gene expression | ENSRNOG00000004392 | 0.7200 | 0.1900 | 5.3e-03 | 0.171 | 0.027 | 0.157 | 0.167 | 1.4e-03 | 1.3e-01 | 2.1e-03 | 1.5e-03 |
8 | IL | gene expression | ENSRNOG00000004392 | 0.3100 | 0.2600 | 2.8e-03 | 0.059 | 0.056 | -0.002 | -0.012 | 1.6e-02 | 1.8e-02 | 3.6e-01 | 9.2e-01 |
9 | IL | mRNA stability | ENSRNOG00000004392 | 0.2560 | 0.1620 | 6.7e-04 | 0.029 | 0.013 | -0.002 | 0.016 | 6.8e-02 | 1.6e-01 | 3.6e-01 | 1.3e-01 |
10 | LHb | mRNA stability | ENSRNOG00000004392 | 0.3540 | 0.1600 | 4.4e-06 | 0.183 | 0.037 | 0.167 | 0.153 | 4.0e-05 | 4.8e-02 | 9.0e-05 | 1.8e-04 |
11 | Liver | alternative TSS | ENSRNOT00000005839 | 0.0314 | 0.0240 | 5.1e-04 | 0.033 | 0.028 | 0.021 | 0.029 | 1.4e-04 | 4.3e-04 | 1.7e-03 | 3.3e-04 |
12 | Liver | alternative TSS | ENSRNOT00000099191 | 0.0289 | 0.0223 | 8.4e-04 | 0.031 | 0.028 | 0.018 | 0.026 | 1.9e-04 | 4.3e-04 | 4.0e-03 | 6.0e-04 |
13 | Liver | gene expression | ENSRNOG00000004392 | 0.1100 | 0.0700 | 1.9e-12 | 0.106 | 0.108 | 0.099 | 0.104 | 9.1e-12 | 5.9e-12 | 4.3e-11 | 1.3e-11 |
14 | NAcc | gene expression | ENSRNOG00000004392 | 0.0660 | 0.0430 | 1.7e-04 | 0.023 | 0.036 | 0.047 | 0.035 | 7.0e-03 | 1.1e-03 | 2.0e-04 | 1.2e-03 |
15 | NAcc | mRNA stability | ENSRNOG00000004392 | 0.3738 | 0.1176 | 0.0e+00 | 0.474 | 0.259 | 0.471 | 0.060 | 2.7e-39 | 2.4e-19 | 5.0e-39 | 2.8e-05 |
16 | OFC | gene expression | ENSRNOG00000004392 | 0.1835 | 0.1177 | 4.6e-03 | 0.022 | -0.012 | -0.013 | -0.004 | 9.7e-02 | 8.7e-01 | 9.9e-01 | 4.1e-01 |
17 | OFC | mRNA stability | ENSRNOG00000004392 | 0.3982 | 0.1591 | 2.7e-07 | 0.148 | 0.010 | 0.084 | 0.075 | 2.3e-04 | 1.8e-01 | 5.0e-03 | 7.8e-03 |
18 | PL | gene expression | ENSRNOG00000004392 | 0.1480 | 0.0880 | 6.7e-10 | 0.106 | 0.128 | 0.117 | 0.111 | 2.1e-08 | 6.2e-10 | 3.3e-09 | 9.0e-09 |
19 | PL | mRNA stability | ENSRNOG00000004392 | 0.2170 | 0.0925 | 0.0e+00 | 0.303 | 0.298 | 0.298 | 0.303 | 2.1e-23 | 5.6e-23 | 5.3e-23 | 2.1e-23 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tibia length | 9.6 | 27.1 | 36.7 | -3.0 | 5.9 | 5.8 | 5.2 | 5.8 | 4.8 | -1.0 | 5.3 | 5.3 | 5.3 | -5.2 | 5.2 | -6.0 | 6.1 | 5.3 | 5.3 | 5.3 | 5.8 | 5.0 |
Baseline Anxiety | 7.4 | 7.8 | 11.3 | 0.8 | -3.2 | -2.5 | -3.0 | -2.4 | -2.9 | 1.8 | -2.8 | -2.9 | -2.9 | 2.9 | -2.9 | 2.9 | -2.9 | -2.9 | -2.9 | -2.9 | -3.4 | -3.1 |
Bone: elastic work | 7.1 | 9.3 | 13.5 | -2.0 | 3.5 | 3.5 | 3.1 | 3.1 | 2.6 | -1.4 | 3.1 | 3.1 | 2.9 | -2.9 | 2.9 | -3.7 | 3.6 | 2.9 | 3.1 | 3.1 | 3.7 | 2.9 |
Bone: cortical area | 6.9 | 10.5 | 13.0 | -1.1 | 3.6 | 3.0 | 3.3 | 3.4 | 3.2 | -1.6 | 3.4 | 3.4 | 3.4 | -3.4 | 3.4 | -3.4 | 3.4 | 3.4 | 3.4 | 3.4 | 3.6 | 3.3 |
Bone: final moment | 6.7 | 11.0 | 14.0 | -0.7 | 3.6 | 2.8 | 3.6 | 3.0 | 3.4 | -1.8 | 3.6 | 3.6 | 3.6 | -3.6 | 3.6 | -3.3 | 3.3 | 3.6 | 3.6 | 3.6 | 3.7 | 3.5 |
Bone: maximum moment | 6.5 | 11.3 | 13.9 | -0.5 | 3.7 | 2.7 | 3.6 | 3.1 | 3.5 | -1.8 | 3.7 | 3.7 | 3.7 | -3.7 | 3.7 | -3.2 | 3.3 | 3.6 | 3.7 | 3.7 | 3.7 | 3.6 |
Bone: final force | 5.9 | 9.6 | 11.8 | -0.5 | 3.4 | 2.5 | 3.4 | 2.8 | 3.2 | -1.7 | 3.4 | 3.4 | 3.4 | -3.4 | 3.4 | -3.0 | 3.0 | 3.4 | 3.4 | 3.4 | 3.4 | 3.3 |
Tail length | 5.8 | 17.6 | 24.0 | 0.7 | 4.3 | 2.7 | 4.7 | 3.9 | 4.9 | -2.8 | 4.6 | 4.6 | 4.7 | -4.8 | 4.7 | -3.4 | 3.6 | 4.8 | 4.6 | 4.6 | 4.2 | 4.8 |
Bone: maximum force | 5.7 | 10.0 | 12.2 | -0.4 | 3.4 | 2.5 | 3.4 | 2.9 | 3.3 | -1.7 | 3.5 | 3.5 | 3.5 | -3.5 | 3.5 | -3.0 | 3.0 | 3.4 | 3.5 | 3.5 | 3.4 | 3.4 |
Bone: cortical thickness | 5.6 | 9.3 | 12.4 | -1.7 | 3.5 | 3.4 | 3.0 | 3.3 | 2.8 | -1.4 | 3.1 | 3.1 | 3.0 | -3.0 | 3.0 | -3.5 | 3.5 | 3.1 | 3.1 | 3.1 | 3.5 | 3.1 |
Delay disc. indifference point, 24s delay | 5.5 | 5.3 | 7.4 | -0.6 | -2.3 | -1.4 | -2.5 | -2.0 | -2.6 | 2.4 | -2.6 | -2.6 | -2.6 | 2.4 | -2.5 | 1.7 | -1.8 | -2.5 | -2.6 | -2.6 | -2.1 | -2.7 |
BMI without tail | 5.2 | 10.8 | 17.4 | 3.0 | 2.5 | -0.0 | 3.6 | 1.1 | 3.9 | -4.2 | 4.0 | 4.0 | 3.8 | -3.6 | 3.6 | -1.0 | 1.4 | 3.7 | 4.0 | 4.0 | 2.7 | 3.7 |
Retroperitoneal fat weight | 5.2 | 17.2 | 25.2 | 0.6 | 4.3 | 2.7 | 4.7 | 3.7 | 4.6 | -3.3 | 4.6 | 4.5 | 4.3 | -4.7 | 4.5 | -3.4 | 3.6 | 4.5 | 4.5 | 4.5 | 4.3 | 5.0 |
Locomotion velocity, session 2 | 5.0 | 5.8 | 7.8 | -0.6 | -2.4 | -1.3 | -2.6 | -1.7 | -2.7 | 2.4 | -2.7 | -2.7 | -2.7 | 2.7 | -2.7 | 1.8 | -1.9 | -2.7 | -2.7 | -2.7 | -2.5 | -2.8 |
Conditioned locomotion | 4.4 | 5.3 | 7.1 | 1.0 | 2.1 | 1.0 | 2.5 | 1.8 | 2.7 | -2.6 | 2.6 | 2.6 | 2.6 | -2.5 | 2.7 | -1.4 | 1.8 | 2.7 | 2.6 | 2.6 | 2.0 | 2.5 |
Body weight | 4.3 | 18.2 | 23.3 | 0.0 | 4.5 | 3.1 | 4.6 | 4.3 | 4.7 | -2.7 | 4.6 | 4.6 | 4.8 | -4.8 | 4.8 | -3.7 | 4.0 | 4.7 | 4.6 | 4.6 | 4.4 | 4.7 |
Condit. Reinf. active responses | 4.1 | 5.0 | 6.8 | 0.3 | 2.3 | 1.4 | 2.6 | 1.8 | 2.5 | -1.8 | 2.6 | 2.5 | 2.5 | -2.5 | 2.5 | -1.8 | 1.9 | 2.5 | 2.5 | 2.5 | 2.3 | 2.4 |
Cocaine induced anxiety | 4.0 | 4.6 | 8.5 | -1.2 | 2.6 | 2.4 | 2.3 | 1.9 | 1.9 | -1.3 | 1.8 | 2.0 | 2.0 | -2.1 | 2.1 | -2.6 | 2.4 | 2.1 | 2.0 | 2.0 | 2.9 | 2.3 |
Bone: periosteal perimeter | 3.8 | 6.2 | 9.9 | -2.1 | 2.9 | 3.1 | 2.3 | 3.1 | 2.1 | 0.2 | 2.4 | 2.4 | 2.3 | -2.4 | 2.4 | -3.2 | 3.1 | 2.3 | 2.4 | 2.4 | 2.9 | 2.1 |
Pavlov. Cond. index score | 3.7 | 4.7 | 8.0 | -1.9 | 2.5 | 2.8 | 2.2 | 2.8 | 1.8 | 0.2 | 2.0 | 1.9 | 1.9 | -2.0 | 1.9 | -2.8 | 2.7 | 1.9 | 1.9 | 1.9 | 2.5 | 1.9 |
Pavlov. Cond. lever-magazine prob. diff. | 3.7 | 4.7 | 7.7 | -1.8 | 2.5 | 2.8 | 2.2 | 2.7 | 1.8 | -0.0 | 2.0 | 2.0 | 2.0 | -2.0 | 2.0 | -2.8 | 2.6 | 1.9 | 2.0 | 2.0 | 2.5 | 2.0 |
Bone: minimum diameter | 3.7 | 6.9 | 8.8 | -0.7 | 2.9 | 2.4 | 2.8 | 2.5 | 2.6 | -1.5 | 2.8 | 2.8 | 2.8 | -2.8 | 2.8 | -2.7 | 2.7 | 2.8 | 2.8 | 2.8 | 3.0 | 2.7 |
Glucose | 3.4 | 5.2 | 9.2 | -2.0 | -1.8 | -0.3 | -2.7 | -1.7 | -3.0 | 2.1 | -2.6 | -2.6 | -2.6 | 2.6 | -2.6 | 0.8 | -1.3 | -2.6 | -2.6 | -2.6 | -1.5 | -2.8 |
Length with tail | 3.3 | 12.2 | 21.6 | -1.7 | 4.0 | 3.8 | 3.6 | 4.6 | 3.5 | -0.5 | 3.3 | 3.3 | 3.5 | -3.7 | 3.6 | -3.9 | 4.0 | 3.6 | 3.2 | 3.2 | 3.7 | 3.6 |
Locomotion distance, session 3 | 3.3 | 3.6 | 4.4 | 0.2 | -2.1 | -1.6 | -2.1 | -1.9 | -2.1 | 1.1 | -2.0 | -2.1 | -2.1 | 2.1 | -2.1 | 1.8 | -1.9 | -2.1 | -2.1 | -2.1 | -2.0 | -2.0 |
Weight adjusted by age | 3.3 | 3.7 | 6.2 | -0.2 | 2.2 | 1.5 | 2.1 | 1.5 | 2.1 | -1.5 | 1.9 | 1.7 | 2.3 | -2.2 | 2.2 | -1.9 | 1.6 | 2.5 | 1.7 | 1.7 | 2.3 | 2.3 |
Saline control response | 3.2 | 4.2 | 5.1 | -0.2 | 2.2 | 1.6 | 2.2 | 2.0 | 2.2 | -1.0 | 2.2 | 2.3 | 2.3 | -2.2 | 2.2 | -1.9 | 2.1 | 2.2 | 2.3 | 2.3 | 2.2 | 2.2 |
Locomotion distance, session 7 | 3.2 | 4.1 | 7.8 | 2.1 | -2.4 | -2.8 | -1.8 | -2.4 | -1.6 | -0.3 | -1.8 | -1.7 | -1.7 | 1.7 | -1.7 | 2.8 | -2.6 | -1.8 | -1.7 | -1.7 | -2.4 | -1.6 |
Bone: cortical tissue density | 3.2 | 4.1 | 5.3 | 0.0 | -2.1 | -1.6 | -2.2 | -2.1 | -2.3 | 1.0 | -2.3 | -2.2 | -2.2 | 2.2 | -2.2 | 1.8 | -2.0 | -2.2 | -2.2 | -2.2 | -2.0 | -2.2 |
Progressive ratio test 1 inactive lever presses | 3.1 | 3.3 | 5.3 | 0.6 | 1.8 | 1.0 | 2.2 | 1.3 | 2.1 | -1.9 | 1.9 | 1.9 | 2.1 | -2.1 | 2.1 | -1.3 | 1.4 | 2.1 | 1.9 | 1.9 | 1.8 | 2.3 |
Short access day 10 total inactive lever presses | 3.1 | 3.4 | 5.0 | -0.3 | 2.1 | 1.6 | 2.2 | 1.8 | 2.0 | -1.4 | 1.8 | 1.8 | 1.9 | -2.1 | 1.9 | -1.9 | 1.9 | 1.9 | 1.8 | 1.8 | 2.2 | 2.1 |
Pavlov. Cond. latency score | 3.1 | 4.0 | 8.3 | -2.3 | 2.3 | 2.9 | 1.8 | 2.8 | 1.4 | 0.7 | 1.6 | 1.6 | 1.6 | -1.7 | 1.6 | -2.8 | 2.6 | 1.6 | 1.6 | 1.6 | 2.3 | 1.5 |
Delay discounting water rate 24 sec | 3.0 | 4.1 | 16.7 | 2.8 | 1.1 | -0.6 | 2.4 | -0.1 | 2.2 | -4.1 | 2.0 | 1.9 | 2.2 | -2.1 | 2.1 | 0.1 | 0.1 | 2.1 | 1.9 | 1.9 | 1.2 | 2.7 |
Change in fecal boli incidents, locomotor task | 3.0 | 2.9 | 5.5 | -1.0 | -1.5 | -0.5 | -2.2 | -1.3 | -2.1 | 2.0 | -1.7 | -1.6 | -2.0 | 2.0 | -2.0 | 0.9 | -0.9 | -2.1 | -1.6 | -1.6 | -1.4 | -2.3 |
Light reinforcement 2 | 2.9 | 3.8 | 5.4 | 0.4 | 1.9 | 1.2 | 2.2 | 1.7 | 2.3 | -2.0 | 2.2 | 2.1 | 2.0 | -2.2 | 2.1 | -1.5 | 1.8 | 2.1 | 2.1 | 2.1 | 1.8 | 2.2 |
Locomotion velocity, session 1 | 2.9 | 3.1 | 5.2 | -1.4 | -1.5 | -0.4 | -2.1 | -1.0 | -2.2 | 2.3 | -2.0 | -2.0 | -2.0 | 2.0 | -2.0 | 0.7 | -1.0 | -1.9 | -2.0 | -2.0 | -1.4 | -2.1 |
Delay discount exponential model param | 2.9 | 3.1 | 4.2 | 0.1 | 1.8 | 1.3 | 1.9 | 2.0 | 1.9 | -1.7 | 1.9 | 2.0 | 2.0 | -1.7 | 1.9 | -1.4 | 1.4 | 1.9 | 1.9 | 1.9 | 1.6 | 2.0 |
Liver weight, right | 2.8 | 4.6 | 9.5 | -1.3 | 2.4 | 2.5 | 2.0 | 3.1 | 2.1 | -0.1 | 2.0 | 1.9 | 2.2 | -2.2 | 2.2 | -2.5 | 2.6 | 2.2 | 1.9 | 1.9 | 2.2 | 2.0 |
Delay discounting water rate 0 sec | 2.7 | 4.3 | 9.9 | 1.3 | 1.9 | 0.7 | 2.6 | 0.9 | 2.4 | -3.2 | 2.0 | 2.1 | 2.3 | -2.5 | 2.2 | -1.1 | 1.0 | 2.2 | 2.1 | 2.1 | 1.9 | 2.9 |
Bone: cortical apparent density | 2.7 | 3.6 | 4.6 | 0.1 | -2.0 | -1.5 | -2.0 | -1.9 | -2.1 | 0.9 | -2.1 | -2.1 | -2.1 | 2.1 | -2.1 | 1.7 | -1.8 | -2.1 | -2.1 | -2.1 | -1.9 | -2.1 |
Delay discount hyperbolic model param | 2.7 | 2.9 | 4.3 | 0.1 | 1.7 | 1.3 | 1.8 | 2.1 | 1.9 | -1.6 | 1.8 | 1.9 | 2.0 | -1.7 | 1.8 | -1.4 | 1.3 | 1.8 | 1.8 | 1.8 | 1.6 | 1.9 |
Locomotion distance, session 1 | 2.6 | 3.4 | 5.2 | 1.2 | -2.1 | -2.1 | -1.7 | -2.1 | -1.6 | 0.3 | -1.9 | -1.8 | -1.8 | 1.8 | -1.8 | 2.2 | -2.3 | -1.8 | -1.8 | -1.8 | -2.1 | -1.5 |
Total resting periods, locomotor time 1 | 2.5 | 2.8 | 4.8 | -0.3 | -1.7 | -1.0 | -2.0 | -1.2 | -1.9 | 1.6 | -1.7 | -1.6 | -1.9 | 2.0 | -2.2 | 1.3 | -1.3 | -2.1 | -1.6 | -1.6 | -1.6 | -1.9 |
K content in liver | 2.5 | 2.5 | 3.6 | 0.3 | 1.6 | 1.0 | 1.7 | 1.5 | 1.9 | -1.4 | 1.7 | 1.7 | 1.7 | -1.8 | 1.7 | -1.2 | 1.4 | 1.8 | 1.7 | 1.7 | 1.4 | 1.8 |
Novel to familiar place preference ratio | 2.4 | 2.5 | 3.5 | -0.7 | 1.7 | 1.6 | 1.7 | 1.3 | 1.3 | -1.5 | 1.6 | 1.6 | 1.6 | -1.6 | 1.6 | -1.7 | 1.9 | 1.6 | 1.6 | 1.6 | 1.8 | 1.3 |
Pavlov. Cond. magazine entry latency | 2.4 | 3.1 | 5.9 | -1.8 | 2.1 | 2.4 | 1.7 | 2.1 | 1.3 | 0.4 | 1.6 | 1.5 | 1.5 | -1.6 | 1.5 | -2.4 | 2.2 | 1.5 | 1.5 | 1.5 | 2.2 | 1.5 |
Condit. Reinf. active-inactive response ratio | 2.3 | 2.4 | 3.7 | -0.8 | 1.8 | 1.8 | 1.6 | 1.9 | 1.5 | -0.8 | 1.4 | 1.5 | 1.6 | -1.6 | 1.5 | -1.8 | 1.8 | 1.6 | 1.5 | 1.5 | 1.7 | 1.6 |
Condit. Reinf. active minus inactive responses | 2.3 | 2.6 | 3.5 | 0.3 | 1.6 | 0.9 | 1.8 | 1.1 | 1.8 | -1.5 | 1.9 | 1.8 | 1.8 | -1.8 | 1.8 | -1.2 | 1.3 | 1.8 | 1.8 | 1.8 | 1.7 | 1.7 |
Novelty place preference | 2.3 | 2.3 | 3.5 | -0.8 | 1.7 | 1.7 | 1.7 | 1.3 | 1.2 | -1.4 | 1.6 | 1.5 | 1.5 | -1.5 | 1.5 | -1.7 | 1.9 | 1.5 | 1.5 | 1.5 | 1.8 | 1.3 |
Pavlov. Cond. response bias | 2.3 | 2.8 | 6.3 | -2.1 | 2.0 | 2.5 | 1.5 | 2.2 | 1.1 | 0.8 | 1.3 | 1.3 | 1.3 | -1.4 | 1.3 | -2.4 | 2.2 | 1.3 | 1.3 | 1.3 | 2.0 | 1.2 |
Bone: periosteal estimation | 2.2 | 4.5 | 5.7 | 0.0 | 2.2 | 1.4 | 2.3 | 2.0 | 2.3 | -1.2 | 2.4 | 2.4 | 2.3 | -2.4 | 2.4 | -1.8 | 1.9 | 2.4 | 2.4 | 2.4 | 2.2 | 2.2 |
Ambulatory time before self-admin | 2.2 | 2.3 | 3.8 | -0.5 | 1.8 | 1.4 | 1.5 | 1.1 | 1.5 | -1.0 | 1.6 | 1.7 | 1.2 | -1.5 | 1.6 | -1.6 | 1.6 | 1.6 | 1.7 | 1.7 | 2.0 | 1.5 |
Cd content in liver | 2.2 | 2.4 | 4.3 | 1.1 | -1.7 | -1.8 | -1.4 | -2.1 | -1.4 | -0.6 | -1.5 | -1.5 | -1.5 | 1.6 | -1.5 | 1.8 | -1.9 | -1.5 | -1.5 | -1.5 | -1.6 | -1.2 |
Pavlov. Cond. magazine entry latency | 2.1 | 2.4 | 5.4 | 2.1 | -1.8 | -2.3 | -1.1 | -2.2 | -1.0 | -0.8 | -1.2 | -1.2 | -1.2 | 1.3 | -1.2 | 2.2 | -2.2 | -1.1 | -1.2 | -1.2 | -1.7 | -0.8 |
Pavlov. Cond. magazine entry number | 2.1 | 2.7 | 6.1 | 2.2 | -2.0 | -2.5 | -1.4 | -2.0 | -0.9 | -0.9 | -1.3 | -1.2 | -1.2 | 1.3 | -1.2 | 2.4 | -2.1 | -1.2 | -1.2 | -1.2 | -2.1 | -1.2 |
Incentive salience index mean | 2.0 | 2.4 | 3.3 | 0.3 | 1.6 | 1.0 | 1.8 | 1.2 | 1.8 | -1.3 | 1.8 | 1.7 | 1.7 | -1.7 | 1.7 | -1.2 | 1.3 | 1.7 | 1.7 | 1.7 | 1.5 | 1.7 |
Bone: maximum diameter | 2.0 | 3.6 | 5.0 | -0.8 | 2.1 | 1.9 | 2.0 | 2.2 | 1.9 | -0.3 | 1.9 | 2.0 | 1.9 | -1.9 | 1.9 | -2.0 | 2.1 | 1.9 | 2.0 | 2.0 | 2.0 | 1.9 |
Time to tail flick, vehicle, after self-admin | 2.0 | 2.1 | 3.4 | -0.4 | -1.5 | -0.8 | -1.8 | -1.1 | -1.5 | 1.6 | -1.5 | -1.5 | -1.5 | 1.7 | -1.6 | 1.1 | -1.2 | -1.7 | -1.5 | -1.5 | -1.6 | -1.7 |
Area under the delay curve | 2.0 | 2.2 | 3.6 | 0.1 | -1.5 | -1.3 | -1.5 | -1.9 | -1.6 | 1.3 | -1.6 | -1.6 | -1.7 | 1.4 | -1.5 | 1.3 | -1.2 | -1.5 | -1.6 | -1.6 | -1.4 | -1.6 |
Bouts of movement, locomotor time 1 | 2.0 | 2.2 | 3.4 | 0.1 | -1.6 | -1.2 | -1.7 | -1.4 | -1.6 | 1.3 | -1.4 | -1.4 | -1.6 | 1.7 | -1.9 | 1.3 | -1.4 | -1.8 | -1.4 | -1.4 | -1.5 | -1.7 |
Delay disc. indifference point, 16s delay | 1.9 | 2.0 | 4.4 | 1.5 | -1.7 | -2.1 | -1.1 | -2.0 | -1.1 | 0.2 | -1.3 | -1.3 | -1.0 | 1.0 | -0.9 | 2.0 | -1.7 | -0.9 | -1.3 | -1.3 | -1.7 | -1.1 |
Parametrial fat weight | 1.8 | 3.6 | 5.1 | -0.3 | 2.0 | 1.6 | 1.9 | 2.3 | 2.0 | -0.8 | 2.0 | 2.0 | 2.2 | -2.0 | 2.1 | -1.8 | 2.0 | 2.1 | 2.0 | 2.0 | 2.0 | 2.0 |
Number of responses in last shaping day | 1.8 | 1.8 | 3.1 | -0.2 | 1.4 | 1.1 | 1.5 | 1.7 | 1.5 | -0.7 | 1.2 | 1.1 | 1.6 | -1.8 | 1.6 | -1.3 | 1.2 | 1.6 | 1.1 | 1.1 | 1.3 | 1.6 |
Time in novel zone, NPP test | 1.8 | 1.9 | 2.7 | -0.5 | 1.5 | 1.4 | 1.5 | 1.1 | 1.1 | -1.4 | 1.4 | 1.4 | 1.4 | -1.4 | 1.4 | -1.4 | 1.6 | 1.4 | 1.4 | 1.4 | 1.6 | 1.2 |
Pavlov. Cond. lever latency | 1.8 | 2.3 | 7.0 | 2.6 | -1.6 | -2.6 | -1.0 | -2.4 | -0.6 | -1.5 | -0.8 | -0.8 | -0.8 | 0.9 | -0.8 | 2.3 | -2.2 | -0.8 | -0.8 | -0.8 | -1.5 | -0.5 |
Bone: cortical thickness | 1.8 | 2.1 | 3.0 | -0.5 | 1.6 | 1.3 | 1.6 | 1.3 | 1.4 | -0.6 | 1.5 | 1.5 | 1.5 | -1.5 | 1.5 | -1.5 | 1.4 | 1.5 | 1.5 | 1.5 | 1.7 | 1.5 |
Reaction time number correct | 1.7 | 2.4 | 13.9 | 3.7 | -0.5 | -2.2 | 0.9 | -1.3 | 1.2 | -3.0 | 0.8 | 0.7 | 0.8 | -0.8 | 0.8 | 1.7 | -1.5 | 1.0 | 0.7 | 0.7 | -0.6 | 1.3 |
Reaction time trials correct on left | 1.7 | 2.4 | 13.9 | 3.7 | -0.5 | -2.2 | 0.9 | -1.3 | 1.2 | -3.0 | 0.8 | 0.7 | 0.8 | -0.8 | 0.8 | 1.7 | -1.5 | 1.0 | 0.7 | 0.7 | -0.6 | 1.3 |
Reaction time trials on left | 1.7 | 2.4 | 14.3 | 3.8 | -0.5 | -2.3 | 1.0 | -1.3 | 1.3 | -3.1 | 0.8 | 0.8 | 0.8 | -0.9 | 0.9 | 1.7 | -1.5 | 1.0 | 0.7 | 0.7 | -0.6 | 1.4 |
Reaction time premature initiation rate | 1.7 | 2.2 | 3.8 | 0.2 | -1.6 | -1.3 | -1.3 | -1.9 | -1.6 | 0.8 | -1.6 | -1.7 | -1.5 | 1.5 | -1.4 | 1.4 | -1.6 | -1.5 | -1.7 | -1.7 | -1.4 | -1.5 |
Reaction time trials completed | 1.7 | 2.4 | 14.3 | 3.8 | -0.5 | -2.3 | 1.0 | -1.3 | 1.3 | -3.1 | 0.8 | 0.8 | 0.8 | -0.9 | 0.9 | 1.7 | -1.5 | 1.0 | 0.7 | 0.7 | -0.6 | 1.4 |
Reaction time trials AUC | 1.7 | 2.5 | 14.2 | 3.8 | -0.4 | -2.2 | 1.0 | -1.2 | 1.3 | -3.1 | 0.8 | 0.8 | 0.9 | -0.9 | 0.9 | 1.7 | -1.4 | 1.1 | 0.8 | 0.8 | -0.5 | 1.4 |
Pavlov. Cond. intertrial magazine entries | 1.7 | 2.2 | 3.0 | -0.1 | 1.6 | 1.2 | 1.7 | 1.5 | 1.6 | -1.2 | 1.5 | 1.6 | 1.6 | -1.7 | 1.6 | -1.4 | 1.5 | 1.6 | 1.6 | 1.6 | 1.5 | 1.6 |
Intermitt. access day 15 inactive lever presses | 1.7 | 1.8 | 3.1 | 0.7 | 1.2 | 0.5 | 1.7 | 1.1 | 1.6 | -1.7 | 1.1 | 1.1 | 1.7 | -1.7 | 1.8 | -0.7 | 0.9 | 1.8 | 1.1 | 1.1 | 1.1 | 1.8 |
Locomotion velocity, session 3 | 1.7 | 2.0 | 2.9 | -0.7 | -1.3 | -0.6 | -1.6 | -1.0 | -1.7 | 1.0 | -1.7 | -1.7 | -1.7 | 1.7 | -1.7 | 0.8 | -1.1 | -1.7 | -1.7 | -1.7 | -1.2 | -1.5 |
Bone: tissue strength | 1.7 | 1.6 | 3.6 | 0.7 | 1.2 | 0.5 | 1.3 | 0.8 | 1.6 | -1.9 | 1.5 | 1.4 | 1.4 | -1.4 | 1.4 | -0.7 | 0.9 | 1.3 | 1.4 | 1.4 | 1.1 | 1.6 |
Vertical activity count, locomotor time 1 | 1.7 | 1.7 | 2.8 | 1.2 | 0.9 | 0.1 | 1.6 | 1.0 | 1.5 | -1.6 | 1.5 | 1.5 | 1.4 | -1.4 | 1.7 | -0.3 | 0.8 | 1.6 | 1.5 | 1.5 | 0.8 | 1.6 |
Light reinforcement 1 | 1.6 | 3.0 | 8.4 | 1.5 | 1.3 | 0.2 | 2.0 | 0.7 | 2.1 | -2.9 | 1.9 | 1.9 | 1.7 | -1.9 | 1.8 | -0.6 | 0.8 | 1.8 | 1.9 | 1.9 | 1.2 | 2.2 |
Pavlov. Cond. magazine entry number | 1.6 | 2.0 | 5.2 | -2.3 | 1.6 | 2.3 | 0.8 | 2.1 | 0.7 | 1.3 | 0.9 | 1.0 | 0.9 | -0.9 | 0.8 | -2.1 | 2.0 | 0.8 | 1.0 | 1.0 | 1.5 | 0.5 |
Progressive ratio test 1 breakpoint | 1.6 | 1.6 | 2.5 | 0.2 | 1.2 | 0.8 | 1.2 | 1.3 | 1.4 | -1.1 | 1.6 | 1.6 | 1.3 | -1.2 | 1.4 | -0.9 | 1.2 | 1.4 | 1.6 | 1.6 | 1.2 | 1.3 |
Locomotion in novel chamber post-restriction | 1.6 | 1.9 | 3.3 | -0.5 | 1.5 | 1.3 | 1.1 | 1.7 | 1.4 | -0.2 | 1.8 | 1.7 | 1.2 | -1.2 | 1.3 | -1.4 | 1.7 | 1.2 | 1.7 | 1.7 | 1.5 | 1.0 |
Soleus weight | 1.5 | 4.5 | 5.8 | -0.3 | 2.3 | 1.7 | 2.4 | 2.1 | 2.4 | -0.8 | 2.3 | 2.3 | 2.3 | -2.4 | 2.3 | -2.0 | 2.1 | 2.3 | 2.3 | 2.3 | 2.2 | 2.3 |
Mean time between licks in bursts | 1.5 | 2.1 | 2.6 | 0.3 | -1.6 | -1.3 | -1.6 | -1.4 | -1.5 | 1.1 | -1.5 | -1.6 | -1.6 | 1.6 | -1.6 | 1.4 | -1.6 | -1.6 | -1.6 | -1.6 | -1.5 | -1.4 |
Reaction time premature initiations | 1.5 | 2.2 | 5.8 | 2.2 | -1.7 | -2.4 | -0.7 | -2.4 | -0.8 | -1.0 | -1.0 | -1.1 | -0.9 | 0.9 | -0.8 | 2.2 | -2.2 | -0.8 | -1.1 | -1.1 | -1.6 | -0.6 |
Conditioned reinforcement - inactives | 1.5 | 1.7 | 2.7 | -0.4 | 1.5 | 1.2 | 1.4 | 1.5 | 1.3 | -0.8 | 0.9 | 1.0 | 1.4 | -1.5 | 1.6 | -1.4 | 1.3 | 1.6 | 1.0 | 1.0 | 1.5 | 1.4 |
Intermittent access intake escalation 2 | 1.5 | 1.5 | 2.7 | -0.9 | 1.4 | 1.4 | 0.9 | 1.4 | 1.0 | -0.1 | 1.1 | 1.1 | 1.4 | -1.0 | 1.4 | -1.5 | 1.6 | 1.4 | 1.1 | 1.1 | 1.5 | 0.7 |
Intermitt. access escalation Index | 1.5 | 1.3 | 2.5 | 0.7 | 1.0 | 0.3 | 1.4 | 0.9 | 1.5 | -1.1 | 1.1 | 1.2 | 1.4 | -1.6 | 1.4 | -0.6 | 0.6 | 1.4 | 1.2 | 1.2 | 0.9 | 1.4 |
Bone: elastic displacement | 1.5 | 1.7 | 2.3 | -0.6 | 1.5 | 1.4 | 1.5 | 1.3 | 1.2 | -1.3 | 1.4 | 1.3 | 1.2 | -1.2 | 1.2 | -1.4 | 1.4 | 1.2 | 1.3 | 1.3 | 1.5 | 1.4 |
Time in closed arm after self-admin | 1.5 | 1.6 | 4.8 | -1.8 | -0.6 | 0.5 | -1.7 | 0.6 | -1.5 | 2.2 | -1.1 | -1.1 | -1.1 | 1.5 | -1.4 | -0.1 | 0.3 | -1.2 | -1.1 | -1.1 | -0.7 | -1.8 |
One hour access (0.3 mA shock) | 1.4 | 1.6 | 2.3 | 0.5 | 1.2 | 0.6 | 1.4 | 1.0 | 1.5 | -1.5 | 1.4 | 1.5 | 1.2 | -1.2 | 1.4 | -0.8 | 1.0 | 1.4 | 1.5 | 1.5 | 1.1 | 1.5 |
Bouts of movement, locomotor time 2 | 1.4 | 1.6 | 2.2 | 0.4 | -1.4 | -1.3 | -1.5 | -1.3 | -1.3 | 0.8 | -1.2 | -1.2 | -1.2 | 1.2 | -1.4 | 1.4 | -1.3 | -1.3 | -1.2 | -1.2 | -1.4 | -1.3 |
Seeking ratio, delayed vs. immediate footshock | 1.4 | 1.6 | 2.6 | -0.2 | 1.4 | 1.0 | 1.2 | 0.9 | 1.4 | -0.5 | 1.6 | 1.4 | 1.4 | -1.2 | 1.5 | -1.3 | 1.3 | 1.2 | 1.4 | 1.4 | 1.4 | 1.2 |
Epididymis fat weight | 1.3 | 3.1 | 4.6 | 1.0 | 1.6 | 0.6 | 2.1 | 1.3 | 2.1 | -1.9 | 2.0 | 2.0 | 2.0 | -2.0 | 1.9 | -1.0 | 1.1 | 1.9 | 2.0 | 2.0 | 1.6 | 2.2 |
Times rat made contact with spout | 1.3 | 1.5 | 3.4 | -1.3 | 1.5 | 1.8 | 1.2 | 1.6 | 0.8 | -1.0 | 1.0 | 0.9 | 0.9 | -1.0 | 0.9 | -1.7 | 1.6 | 1.0 | 0.9 | 0.9 | 1.5 | 1.3 |
Intermittent access terminal intake (last 3 days) | 1.3 | 1.4 | 1.9 | -0.2 | 1.3 | 1.0 | 1.3 | 1.0 | 1.3 | -0.7 | 1.2 | 1.3 | 1.2 | -1.2 | 1.4 | -1.2 | 1.3 | 1.4 | 1.3 | 1.3 | 1.3 | 1.2 |
Progressive ratio test 1 active lever presses | 1.3 | 1.3 | 1.9 | 0.2 | 1.1 | 0.7 | 1.1 | 1.2 | 1.3 | -1.0 | 1.3 | 1.4 | 1.2 | -1.1 | 1.3 | -0.8 | 1.1 | 1.3 | 1.4 | 1.4 | 1.0 | 1.2 |
Short access day 1 total infusions | 1.3 | 1.4 | 2.0 | -0.1 | -1.3 | -0.7 | -1.4 | -0.9 | -1.3 | 0.9 | -1.3 | -1.3 | -1.2 | 1.3 | -1.2 | 1.0 | -1.0 | -1.2 | -1.3 | -1.3 | -1.3 | -1.3 |
Pavlov. Cond. lever contacts | 1.3 | 1.5 | 3.7 | -1.7 | 1.4 | 1.9 | 1.1 | 1.9 | 0.8 | 0.7 | 0.9 | 0.8 | 0.8 | -0.9 | 0.8 | -1.8 | 1.7 | 0.8 | 0.8 | 0.8 | 1.3 | 0.7 |
Delay disc. indifference point, 8s delay | 1.3 | 1.3 | 2.8 | -0.8 | -1.0 | -0.4 | -1.3 | -1.0 | -1.3 | 1.7 | -1.2 | -1.3 | -1.4 | 1.2 | -1.3 | 0.5 | -0.5 | -1.3 | -1.2 | -1.2 | -0.8 | -1.5 |
Run reversals in cocaine runway, females | 1.3 | 1.3 | 5.3 | 1.5 | -1.3 | -1.8 | -1.0 | -2.3 | -0.7 | -0.2 | -0.4 | -0.4 | -0.8 | 0.9 | -0.9 | 1.6 | -1.6 | -0.9 | -0.4 | -0.4 | -1.2 | -0.7 |
Run reversals in cocaine runway, males | 1.3 | 1.2 | 2.6 | -1.4 | 1.3 | 1.6 | 0.7 | 1.4 | 0.7 | 0.3 | 1.0 | 0.9 | 0.9 | -0.9 | 0.9 | -1.6 | 1.6 | 0.9 | 1.0 | 1.0 | 1.4 | 0.4 |
Std. dev. time between licks in bursts | 1.2 | 1.4 | 5.5 | 2.3 | 0.3 | -1.1 | 1.0 | -0.0 | 1.5 | -2.2 | 1.2 | 1.1 | 1.1 | -1.0 | 1.1 | 0.6 | -0.4 | 1.1 | 1.1 | 1.1 | 0.2 | 1.4 |
Delay discounting water rate 18 sec | 1.2 | 1.6 | 6.6 | 1.6 | 0.8 | -0.1 | 1.6 | 0.4 | 1.5 | -2.6 | 1.1 | 1.1 | 1.3 | -1.3 | 1.3 | -0.1 | 0.1 | 1.3 | 1.0 | 1.0 | 0.7 | 1.9 |
Pavlov. Cond. lever contacts | 1.2 | 1.7 | 5.9 | 1.9 | 0.7 | -0.6 | 1.5 | -0.0 | 1.5 | -2.4 | 1.3 | 1.3 | 1.3 | -1.3 | 1.4 | 0.1 | -0.0 | 1.4 | 1.3 | 1.3 | 0.7 | 1.7 |
Intermitt. access day 1 inactive lever presses | 1.2 | 1.3 | 2.3 | -0.3 | 1.4 | 1.0 | 1.5 | 1.2 | 1.2 | -1.0 | 0.8 | 0.8 | 1.1 | -1.4 | 1.2 | -1.2 | 0.9 | 1.2 | 0.8 | 0.8 | 1.5 | 1.5 |
Bone: cortical porosity | 1.2 | 1.3 | 5.2 | -2.3 | 1.3 | 2.0 | 0.5 | 1.3 | 0.1 | 1.1 | 0.6 | 0.5 | 0.6 | -0.6 | 0.6 | -1.9 | 1.6 | 0.6 | 0.5 | 0.5 | 1.5 | 0.4 |
Bone: cortical porosity | 1.2 | 1.3 | 3.4 | -1.8 | 1.4 | 1.8 | 0.8 | 1.2 | 0.4 | 0.7 | 0.9 | 0.8 | 0.9 | -0.9 | 0.9 | -1.8 | 1.6 | 0.9 | 0.8 | 0.8 | 1.5 | 0.6 |
Extinction: sum of active levers before priming | 1.2 | 1.2 | 2.0 | 0.1 | -1.2 | -0.8 | -1.0 | -1.1 | -1.3 | 0.4 | -1.3 | -1.2 | -1.4 | 1.2 | -1.2 | 1.0 | -1.0 | -1.2 | -1.2 | -1.2 | -1.1 | -1.0 |
Reaction time false alarm rate | 1.1 | 1.6 | 6.4 | -1.6 | -0.7 | 0.2 | -1.6 | -0.7 | -1.5 | 2.5 | -1.3 | -1.2 | -1.2 | 1.5 | -1.2 | 0.1 | -0.3 | -1.2 | -1.1 | -1.1 | -0.6 | -1.7 |
Locomotion distance, session 8 | 1.1 | 1.6 | 9.8 | 3.1 | -0.5 | -2.0 | 0.5 | -1.0 | 1.0 | -2.4 | 0.7 | 0.6 | 0.6 | -0.6 | 0.6 | 1.5 | -1.2 | 0.6 | 0.6 | 0.6 | -0.5 | 0.9 |
Bone: trabecular spacing | 1.1 | 1.5 | 8.8 | 2.7 | -0.0 | -1.4 | 0.8 | -0.9 | 1.1 | -3.0 | 0.8 | 0.7 | 0.7 | -0.7 | 0.7 | 1.0 | -0.9 | 0.7 | 0.7 | 0.7 | -0.0 | 1.2 |
Delta ambulatory time before/after self-admin | 1.1 | 1.2 | 2.4 | 1.4 | -1.3 | -1.4 | -0.6 | -1.4 | -0.7 | -0.7 | -1.0 | -1.0 | -0.7 | 0.7 | -0.9 | 1.5 | -1.5 | -0.9 | -1.0 | -1.0 | -1.4 | -0.3 |
Condit. Reinf. active-inactive response ratio | 1.0 | 1.1 | 1.6 | 0.5 | 1.0 | 0.4 | 1.2 | 0.7 | 1.2 | -1.2 | 1.3 | 1.2 | 1.2 | -1.2 | 1.2 | -0.7 | 0.8 | 1.2 | 1.2 | 1.2 | 1.1 | 1.1 |
Condit. Reinf. inactive responses | 1.0 | 1.2 | 1.6 | 0.1 | 1.1 | 0.7 | 1.3 | 0.8 | 1.3 | -0.8 | 1.2 | 1.2 | 1.2 | -1.2 | 1.2 | -0.9 | 0.9 | 1.2 | 1.2 | 1.2 | 1.1 | 1.1 |
Locomotion velocity, hab. session 2 | 1.0 | 1.3 | 3.8 | 1.9 | 0.5 | -0.6 | 1.2 | -0.0 | 1.5 | -2.0 | 1.2 | 1.2 | 1.2 | -1.2 | 1.2 | 0.2 | -0.1 | 1.1 | 1.2 | 1.2 | 0.4 | 1.4 |
Distance traveled before self-admin | 1.0 | 1.1 | 2.2 | -0.6 | 1.3 | 1.1 | 1.0 | 0.7 | 0.9 | -0.5 | 1.0 | 1.2 | 0.7 | -1.0 | 1.1 | -1.3 | 1.2 | 1.1 | 1.2 | 1.2 | 1.5 | 0.9 |
Delay discounting total patch changes 24 sec | 0.9 | 1.1 | 2.6 | 0.5 | 1.0 | 0.4 | 1.4 | 0.5 | 1.2 | -1.4 | 1.0 | 1.1 | 1.2 | -1.2 | 1.1 | -0.7 | 0.5 | 1.2 | 1.0 | 1.0 | 1.1 | 1.6 |
Condit. Reinf. active minus inactive responses | 0.9 | 1.1 | 1.6 | 0.1 | 1.1 | 0.8 | 1.3 | 1.1 | 1.2 | -1.1 | 1.0 | 1.0 | 1.1 | -1.2 | 1.1 | -0.8 | 1.0 | 1.2 | 1.0 | 1.0 | 1.0 | 1.2 |
Pavlov. Cond. lever latency | 0.9 | 1.3 | 5.1 | -1.8 | -0.5 | 0.7 | -1.3 | 0.2 | -1.2 | 2.3 | -1.0 | -1.0 | -1.1 | 1.2 | -1.2 | -0.2 | 0.2 | -1.2 | -1.0 | -1.0 | -0.6 | -1.5 |
Context. condit. distance diff. score | 0.9 | 1.1 | 4.6 | 2.1 | 0.2 | -1.0 | 0.8 | -0.3 | 1.2 | -2.0 | 1.0 | 1.0 | 1.0 | -1.0 | 1.0 | 0.6 | -0.3 | 1.0 | 1.0 | 1.0 | 0.2 | 1.0 |
Total resting periods, locomotor time 2 | 0.9 | 0.9 | 1.5 | 0.6 | -1.2 | -1.1 | -1.1 | -1.0 | -0.9 | 0.5 | -0.9 | -0.9 | -0.8 | 0.9 | -1.1 | 1.2 | -1.1 | -1.0 | -0.9 | -0.9 | -1.2 | -1.0 |
Fe content in liver | 0.9 | 1.0 | 1.4 | 0.5 | -1.1 | -1.0 | -1.1 | -1.1 | -1.0 | 0.2 | -1.1 | -1.1 | -1.1 | 1.1 | -1.1 | 1.1 | -1.2 | -1.0 | -1.1 | -1.1 | -1.1 | -0.8 |
Rb content in liver | 0.9 | 1.1 | 2.3 | 1.1 | 0.8 | 0.0 | 1.2 | 0.6 | 1.3 | -1.5 | 1.2 | 1.2 | 1.2 | -1.1 | 1.2 | -0.2 | 0.5 | 1.2 | 1.2 | 1.2 | 0.7 | 1.2 |
Length without tail | 0.8 | 1.7 | 9.6 | -3.1 | 0.6 | 2.3 | -0.2 | 1.9 | -0.7 | 2.2 | -0.8 | -0.8 | -0.4 | 0.3 | -0.4 | -1.6 | 1.4 | -0.4 | -0.8 | -0.8 | 0.5 | -0.3 |
Indifference point function ln k | 0.8 | 1.1 | 1.5 | 0.6 | -1.2 | -1.2 | -1.1 | -1.2 | -1.0 | 0.3 | -0.9 | -1.0 | -0.9 | 1.1 | -1.0 | 1.2 | -1.2 | -1.0 | -0.9 | -0.9 | -1.2 | -1.2 |
Indifference point function log k | 0.8 | 1.1 | 1.5 | 0.6 | -1.2 | -1.2 | -1.1 | -1.2 | -1.0 | 0.3 | -0.9 | -1.0 | -0.9 | 1.1 | -1.0 | 1.2 | -1.2 | -1.0 | -0.9 | -0.9 | -1.2 | -1.2 |
Pavlov. Cond. lever-magazine prob. diff. | 0.8 | 1.1 | 4.6 | 2.1 | -0.9 | -1.8 | -0.1 | -1.7 | -0.1 | -1.7 | -0.3 | -0.3 | -0.2 | 0.2 | -0.1 | 1.5 | -1.5 | -0.1 | -0.3 | -0.3 | -0.7 | 0.2 |
Total locomotion distance, hab. session 2 | 0.8 | 1.0 | 4.2 | 2.0 | 0.2 | -0.9 | 1.0 | -0.4 | 1.2 | -2.1 | 0.9 | 0.9 | 0.9 | -0.9 | 0.9 | 0.6 | -0.4 | 0.8 | 0.9 | 0.9 | 0.1 | 1.1 |
Total zone transitions, NPP test | 0.8 | 1.2 | 5.2 | 2.3 | -1.2 | -2.0 | -0.4 | -1.4 | -0.1 | -1.1 | -0.4 | -0.4 | -0.4 | 0.4 | -0.4 | 1.8 | -1.7 | -0.4 | -0.4 | -0.4 | -1.2 | -0.1 |
Total locomotion distance, NPP test | 0.8 | 1.1 | 6.6 | 2.6 | -0.3 | -1.6 | 0.6 | -0.8 | 0.9 | -2.0 | 0.5 | 0.5 | 0.5 | -0.5 | 0.5 | 1.2 | -1.0 | 0.5 | 0.5 | 0.5 | -0.4 | 0.8 |
Bone: endosteal perimeter | 0.8 | 1.6 | 2.3 | -0.5 | 1.4 | 1.1 | 1.2 | 1.5 | 1.3 | 0.3 | 1.4 | 1.4 | 1.3 | -1.4 | 1.4 | -1.3 | 1.3 | 1.3 | 1.4 | 1.4 | 1.4 | 1.1 |
Bone: trabecular tissue density | 0.8 | 1.2 | 1.6 | -0.1 | -1.1 | -0.8 | -1.1 | -1.2 | -1.1 | 0.9 | -1.2 | -1.2 | -1.2 | 1.2 | -1.2 | 0.9 | -1.1 | -1.2 | -1.2 | -1.2 | -1.1 | -1.1 |
Food consumed during 24 hour testing period | 0.7 | 0.8 | 3.1 | 0.5 | 0.8 | 0.4 | 1.1 | 0.9 | 1.0 | -1.8 | 0.8 | 0.8 | 0.9 | -0.9 | 0.9 | -0.5 | 0.6 | 1.0 | 0.8 | 0.8 | 0.8 | 1.3 |
Reaction time num false alarms AUC | 0.7 | 1.1 | 1.9 | 0.3 | -1.1 | -1.0 | -1.2 | -1.4 | -1.0 | 1.2 | -1.0 | -0.9 | -0.9 | 1.3 | -0.8 | 1.0 | -1.1 | -0.8 | -0.9 | -0.9 | -1.0 | -1.1 |
Cocaine response after cond. not corrected | 0.7 | 0.7 | 1.1 | -0.2 | -0.8 | -0.5 | -1.0 | -1.0 | -1.0 | 0.6 | -0.9 | -0.9 | -0.9 | 1.1 | -0.9 | 0.6 | -0.8 | -1.0 | -0.9 | -0.9 | -0.6 | -1.0 |
Cocaine response before conditioning | 0.7 | 0.8 | 1.3 | 0.1 | -1.0 | -0.7 | -1.0 | -0.5 | -0.8 | 0.8 | -1.0 | -0.9 | -1.0 | 1.0 | -0.9 | 0.9 | -0.8 | -0.9 | -0.9 | -0.9 | -1.1 | -1.1 |
Condit. Reinf. inactive responses | 0.7 | 0.9 | 2.2 | 1.2 | -1.1 | -1.4 | -0.6 | -1.5 | -0.7 | -0.7 | -0.7 | -0.7 | -0.8 | 0.7 | -0.7 | 1.3 | -1.3 | -0.7 | -0.7 | -0.7 | -1.0 | -0.5 |
Pavlov. Cond. change in total contacts | 0.7 | 0.9 | 4.3 | 2.1 | -0.8 | -1.7 | -0.0 | -1.6 | -0.0 | -1.5 | -0.2 | -0.2 | -0.1 | 0.2 | -0.1 | 1.4 | -1.4 | -0.1 | -0.2 | -0.2 | -0.7 | 0.1 |
Pavlov. Cond. index score | 0.7 | 0.9 | 4.3 | 2.1 | -0.7 | -1.6 | 0.1 | -1.5 | 0.1 | -1.8 | -0.1 | -0.2 | -0.0 | 0.1 | 0.0 | 1.3 | -1.3 | 0.1 | -0.2 | -0.2 | -0.6 | 0.4 |
Pavlov. Cond. latency score | 0.7 | 0.8 | 4.5 | 2.1 | -0.6 | -1.6 | 0.2 | -1.4 | 0.2 | -1.7 | -0.0 | -0.1 | 0.1 | -0.0 | 0.1 | 1.3 | -1.2 | 0.2 | -0.1 | -0.1 | -0.5 | 0.5 |
Intermittent access day 15 total infusions | 0.7 | 0.7 | 1.1 | 0.2 | 0.9 | 0.5 | 0.9 | 0.5 | 1.0 | -0.7 | 0.9 | 1.0 | 1.0 | -0.8 | 1.1 | -0.7 | 0.8 | 1.1 | 1.0 | 1.0 | 0.9 | 1.0 |
Intermittent access total locomotion | 0.7 | 0.8 | 1.2 | -0.2 | 0.9 | 0.8 | 0.9 | 1.1 | 0.9 | -0.7 | 0.7 | 0.8 | 0.9 | -0.9 | 1.0 | -0.8 | 0.9 | 1.0 | 0.8 | 0.8 | 0.9 | 1.1 |
Locomotion velocity, session 7 | 0.7 | 0.8 | 1.1 | 0.5 | -1.0 | -1.0 | -1.0 | -1.0 | -0.8 | 0.2 | -0.8 | -0.9 | -0.9 | 0.9 | -0.9 | 1.0 | -1.0 | -0.9 | -0.9 | -0.9 | -1.0 | -0.8 |
Locomotion velocity, session 8 | 0.7 | 0.8 | 2.3 | 1.5 | -1.0 | -1.5 | -0.5 | -1.3 | -0.3 | -0.7 | -0.6 | -0.6 | -0.6 | 0.6 | -0.6 | 1.4 | -1.3 | -0.6 | -0.6 | -0.6 | -1.1 | -0.3 |
Degree of sensitization distance | 0.7 | 0.7 | 2.6 | 1.2 | 0.4 | -0.3 | 0.9 | 0.3 | 1.0 | -1.6 | 0.8 | 0.9 | 0.9 | -0.9 | 0.9 | 0.1 | 0.2 | 0.9 | 0.9 | 0.9 | 0.4 | 1.0 |
Total zone transitions, hab. session 2 | 0.7 | 0.9 | 4.2 | 2.0 | -0.9 | -1.7 | -0.2 | -1.3 | 0.0 | -1.2 | -0.3 | -0.3 | -0.3 | 0.3 | -0.3 | 1.5 | -1.4 | -0.3 | -0.3 | -0.3 | -1.0 | 0.0 |
Locomotion velocity, NPP test | 0.7 | 0.9 | 4.9 | 2.2 | -0.0 | -1.2 | 0.8 | -0.6 | 1.0 | -1.9 | 0.7 | 0.7 | 0.7 | -0.7 | 0.7 | 0.8 | -0.6 | 0.7 | 0.7 | 0.7 | -0.1 | 0.9 |
Bone: stiffness | 0.7 | 1.2 | 1.6 | -0.0 | 1.1 | 0.7 | 1.1 | 1.1 | 1.2 | -0.1 | 1.3 | 1.2 | 1.3 | -1.3 | 1.3 | -0.9 | 1.0 | 1.3 | 1.2 | 1.2 | 1.1 | 1.0 |
Bone: trabecular thickness | 0.7 | 0.8 | 3.4 | -1.8 | 0.9 | 1.5 | 0.2 | 1.0 | -0.0 | 1.3 | 0.4 | 0.4 | 0.5 | -0.4 | 0.4 | -1.4 | 1.3 | 0.4 | 0.4 | 0.4 | 1.0 | 0.0 |
Distance traveled after self-admin | 0.7 | 0.8 | 2.9 | 1.2 | 0.5 | -0.3 | 0.9 | -0.1 | 0.9 | -1.7 | 0.9 | 1.0 | 0.7 | -0.8 | 0.9 | 0.0 | 0.1 | 0.9 | 1.0 | 1.0 | 0.5 | 1.2 |
Distance moved, locomotor task time 1 | 0.7 | 0.8 | 1.2 | 0.5 | 0.7 | 0.3 | 1.1 | 0.6 | 1.1 | -0.8 | 1.1 | 1.1 | 0.9 | -0.9 | 1.0 | -0.4 | 0.6 | 0.9 | 1.1 | 1.1 | 0.7 | 1.1 |
BMI with tail | 0.6 | 2.0 | 4.6 | 1.5 | 1.0 | -0.2 | 1.4 | 0.3 | 1.6 | -2.1 | 1.8 | 1.7 | 1.7 | -1.5 | 1.5 | -0.3 | 0.5 | 1.5 | 1.8 | 1.8 | 1.1 | 1.6 |
Delay discounting time to switch 0 sec | 0.6 | 0.9 | 2.5 | -0.4 | -0.9 | -0.5 | -1.2 | -0.5 | -1.0 | 1.6 | -0.9 | -0.9 | -0.9 | 1.1 | -0.8 | 0.6 | -0.6 | -0.9 | -0.9 | -0.9 | -0.9 | -1.4 |
Delay discounting water rate 12 sec | 0.6 | 0.9 | 5.4 | 1.9 | 0.1 | -0.9 | 0.8 | -0.5 | 0.8 | -2.3 | 0.7 | 0.7 | 0.7 | -0.9 | 0.7 | 0.6 | -0.4 | 0.9 | 0.7 | 0.7 | 0.1 | 1.0 |
Locomotor activity | 0.6 | 0.9 | 1.5 | 0.2 | -1.0 | -0.7 | -0.9 | -0.8 | -1.0 | 0.3 | -1.2 | -1.1 | -1.0 | 1.0 | -1.0 | 0.9 | -1.0 | -1.0 | -1.1 | -1.1 | -1.0 | -0.9 |
Pavlov. Cond. response bias | 0.6 | 0.8 | 4.3 | 2.0 | -0.2 | -1.2 | 0.6 | -0.8 | 0.6 | -2.1 | 0.4 | 0.4 | 0.5 | -0.5 | 0.5 | 0.9 | -0.8 | 0.6 | 0.4 | 0.4 | -0.1 | 0.8 |
Intermittent access total infusions | 0.6 | 0.6 | 1.0 | 0.1 | 0.8 | 0.5 | 0.8 | 0.5 | 0.9 | -0.8 | 0.9 | 0.9 | 0.8 | -0.8 | 0.9 | -0.7 | 0.8 | 0.9 | 0.9 | 0.9 | 0.8 | 1.0 |
Intermittent access day 1 locomotion | 0.6 | 0.6 | 1.1 | 0.2 | 0.7 | 0.4 | 0.8 | 0.8 | 0.9 | -0.8 | 0.7 | 0.7 | 0.9 | -0.9 | 0.9 | -0.5 | 0.5 | 0.9 | 0.7 | 0.7 | 0.7 | 1.1 |
Intermittent access day 15 total locomotion | 0.6 | 0.6 | 1.1 | -0.6 | 0.9 | 1.0 | 0.7 | 1.0 | 0.7 | -0.2 | 0.6 | 0.7 | 0.6 | -0.7 | 0.7 | -1.0 | 1.0 | 0.7 | 0.7 | 0.7 | 0.8 | 0.7 |
Short access day 10 total infusions | 0.6 | 0.6 | 0.9 | -0.4 | 0.9 | 0.9 | 0.8 | 0.8 | 0.8 | -0.6 | 0.7 | 0.7 | 0.7 | -0.7 | 0.7 | -0.9 | 0.9 | 0.7 | 0.7 | 0.7 | 0.9 | 0.9 |
Short access total locomotion | 0.6 | 0.6 | 1.6 | -1.2 | -0.4 | 0.5 | -0.9 | 0.4 | -0.8 | 1.3 | -0.9 | -0.9 | -0.9 | 0.8 | -0.8 | -0.1 | 0.2 | -0.8 | -0.9 | -0.9 | -0.5 | -0.9 |
Compulsive drug intake | 0.6 | 0.6 | 1.0 | 0.7 | 0.6 | -0.0 | 0.9 | 0.3 | 0.8 | -1.0 | 0.8 | 0.8 | 0.9 | -0.8 | 0.9 | -0.2 | 0.1 | 0.9 | 0.8 | 0.8 | 0.7 | 0.9 |
Stereotopy head waving duration, day 7 | 0.6 | 0.7 | 1.0 | -0.4 | 1.0 | 1.0 | 0.9 | 0.8 | 0.8 | -0.9 | 0.9 | 0.7 | 0.7 | -0.7 | 0.7 | -1.0 | 0.9 | 0.8 | 0.7 | 0.7 | 0.9 | 0.8 |
Degree of sensitization stereotypy | 0.6 | 0.6 | 1.6 | 0.5 | 0.7 | 0.2 | 0.9 | 0.1 | 0.9 | -1.3 | 1.0 | 0.8 | 0.8 | -0.8 | 0.8 | -0.4 | 0.4 | 0.8 | 0.8 | 0.8 | 0.7 | 1.0 |
Delta distance traveled before/after self-admin | 0.6 | 0.6 | 2.5 | 1.6 | -0.8 | -1.2 | -0.0 | -1.2 | -0.1 | -1.2 | -0.3 | -0.4 | -0.2 | 0.2 | -0.3 | 1.2 | -1.1 | -0.4 | -0.4 | -0.4 | -0.9 | 0.4 |
Time in closed arm before self-admin | 0.6 | 0.6 | 1.9 | -0.6 | -0.6 | -0.3 | -1.4 | -1.0 | -1.0 | 1.2 | -0.3 | -0.3 | -0.9 | 1.0 | -1.1 | 0.3 | -0.3 | -1.0 | -0.3 | -0.3 | -0.4 | -1.2 |
Delay disc. indifference point, 4s delay | 0.6 | 0.7 | 1.4 | -0.3 | -0.7 | -0.3 | -0.8 | -1.1 | -0.9 | 0.6 | -0.8 | -0.9 | -1.2 | 0.9 | -1.1 | 0.5 | -0.2 | -1.1 | -0.8 | -0.8 | -0.7 | -0.7 |
Sr content in liver | 0.6 | 0.5 | 2.5 | -1.6 | -0.0 | 0.7 | -0.5 | 0.0 | -0.8 | 1.6 | -0.5 | -0.5 | -0.5 | 0.6 | -0.5 | -0.5 | 0.3 | -0.5 | -0.5 | -0.5 | 0.1 | -0.8 |
Locomotor testing distance | 0.5 | 0.9 | 1.8 | 0.8 | -1.1 | -1.2 | -0.6 | -1.2 | -0.8 | -0.2 | -1.3 | -1.1 | -0.8 | 0.6 | -0.7 | 1.2 | -1.4 | -0.7 | -1.1 | -1.1 | -1.0 | -0.6 |
Condit. Reinf. lever presses | 0.5 | 0.6 | 3.4 | 1.6 | 0.1 | -0.8 | 0.8 | -0.5 | 0.7 | -1.9 | 0.5 | 0.5 | 0.7 | -0.6 | 0.7 | 0.5 | -0.4 | 0.7 | 0.5 | 0.5 | 0.1 | 0.9 |
Conditioned locomotion | 0.5 | 0.5 | 1.3 | -0.2 | 0.8 | 0.8 | 0.9 | 1.1 | 0.9 | -0.7 | 0.4 | 0.4 | 0.8 | -0.8 | 0.8 | -0.7 | 0.7 | 0.8 | 0.4 | 0.4 | 0.6 | 1.1 |
Progressive ratio test 2 breakpoint | 0.5 | 0.6 | 0.9 | -0.0 | 0.8 | 0.7 | 0.7 | 1.0 | 0.9 | -0.6 | 0.8 | 0.8 | 0.8 | -0.9 | 0.8 | -0.7 | 0.8 | 0.8 | 0.8 | 0.8 | 0.7 | 0.9 |
Progressive ratio test 2 inactive lever presses | 0.5 | 0.5 | 0.8 | -0.4 | 0.9 | 0.9 | 0.8 | 0.7 | 0.7 | -0.5 | 0.5 | 0.5 | 0.7 | -0.7 | 0.9 | -0.9 | 0.8 | 0.9 | 0.5 | 0.5 | 0.9 | 0.9 |
Locomotion distance, session 2 | 0.5 | 0.7 | 1.6 | 1.1 | -1.0 | -1.3 | -0.5 | -1.0 | -0.5 | -0.3 | -0.7 | -0.6 | -0.6 | 0.6 | -0.6 | 1.2 | -1.2 | -0.6 | -0.6 | -0.6 | -1.0 | -0.5 |
Stereotopy head waving bouts, day 3 | 0.5 | 0.6 | 1.0 | -0.7 | -0.6 | 0.0 | -0.8 | -0.6 | -1.0 | 0.6 | -1.0 | -1.0 | -1.0 | 1.0 | -1.0 | 0.2 | -0.4 | -1.0 | -1.0 | -1.0 | -0.7 | -0.9 |
Total zone transitions, hab. session 1 | 0.5 | 0.7 | 2.1 | 1.1 | -0.9 | -1.2 | -0.6 | -1.4 | -0.5 | -0.4 | -0.6 | -0.6 | -0.6 | 0.6 | -0.6 | 1.1 | -1.2 | -0.6 | -0.6 | -0.6 | -0.8 | -0.3 |
Ambulatory time after self-admin | 0.5 | 0.6 | 2.5 | 0.9 | 0.5 | -0.0 | 0.8 | -0.0 | 0.8 | -1.6 | 0.7 | 0.8 | 0.6 | -0.7 | 0.8 | -0.1 | 0.2 | 0.8 | 0.8 | 0.8 | 0.5 | 1.1 |
Fecal boli incidents, locomotor time 1 | 0.5 | 0.5 | 0.8 | 0.3 | -0.8 | -0.7 | -0.8 | -0.8 | -0.7 | 0.1 | -0.7 | -0.8 | -0.7 | 0.8 | -0.5 | 0.8 | -0.8 | -0.6 | -0.8 | -0.8 | -0.9 | -0.7 |
Time >=10cm from walls, locomotor time 1 | 0.5 | 0.5 | 1.3 | 1.2 | 0.0 | -0.4 | 0.3 | 0.4 | 0.7 | -1.0 | 1.1 | 1.1 | 0.6 | -0.2 | 0.5 | 0.4 | 0.2 | 0.4 | 1.1 | 1.1 | -0.2 | 0.4 |
Cu content in liver | 0.5 | 0.6 | 2.4 | -1.5 | 0.8 | 1.4 | 0.3 | 1.0 | 0.0 | 0.4 | 0.3 | 0.3 | 0.3 | -0.4 | 0.3 | -1.2 | 1.2 | 0.4 | 0.3 | 0.3 | 0.9 | 0.2 |
Heart weight | 0.4 | 0.5 | 0.9 | 0.1 | 0.7 | 0.3 | 0.9 | 0.2 | 0.8 | -0.7 | 0.9 | 0.8 | 0.8 | -0.9 | 0.7 | -0.6 | 0.4 | 0.6 | 0.9 | 0.9 | 0.9 | 0.8 |
Intraocular pressure | 0.4 | 0.5 | 1.0 | 0.7 | 0.5 | -0.1 | 0.5 | 0.1 | 0.8 | -0.9 | 1.0 | 0.9 | 1.0 | -0.8 | 1.0 | -0.2 | 0.3 | 0.9 | 0.9 | 0.9 | 0.6 | 0.5 |
Delay discounting total patch changes 18 sec | 0.4 | 0.6 | 2.3 | 1.5 | -0.6 | -1.3 | -0.1 | -1.3 | -0.1 | -1.3 | -0.0 | 0.0 | -0.1 | 0.2 | -0.0 | 1.1 | -1.1 | -0.1 | -0.1 | -0.1 | -0.6 | 0.1 |
Delay discounting total patch changes 6 sec | 0.4 | 0.6 | 1.1 | -0.7 | 1.0 | 1.0 | 1.1 | 0.7 | 0.7 | -0.3 | 0.7 | 0.7 | 0.6 | -0.7 | 0.6 | -1.0 | 1.0 | 0.8 | 0.7 | 0.7 | 1.0 | 0.9 |
Reaction time num false alarms | 0.4 | 0.5 | 1.5 | 0.2 | -0.7 | -0.7 | -0.8 | -1.2 | -0.7 | 0.9 | -0.6 | -0.5 | -0.7 | 0.9 | -0.6 | 0.6 | -0.8 | -0.5 | -0.4 | -0.4 | -0.6 | -0.8 |
Social response proportion | 0.4 | 0.4 | 0.9 | 0.8 | -0.7 | -0.9 | -0.4 | -0.8 | -0.4 | -0.3 | -0.6 | -0.6 | -0.4 | 0.3 | -0.5 | 0.9 | -1.0 | -0.4 | -0.6 | -0.6 | -0.8 | -0.2 |
Condit. Reinf. lever reinforcers received | 0.4 | 0.6 | 3.8 | 1.4 | 0.1 | -0.7 | 0.8 | -0.4 | 0.6 | -2.0 | 0.5 | 0.5 | 0.6 | -0.6 | 0.7 | 0.4 | -0.3 | 0.7 | 0.5 | 0.5 | 0.2 | 0.8 |
Intermittent access intake day 1-15 change | 0.4 | 0.4 | 0.7 | -0.2 | 0.7 | 0.5 | 0.3 | 0.6 | 0.5 | -0.2 | 0.7 | 0.7 | 0.8 | -0.5 | 0.8 | -0.6 | 0.8 | 0.8 | 0.7 | 0.7 | 0.7 | 0.4 |
Intermittent access intake escalation | 0.4 | 0.4 | 0.8 | 0.0 | 0.7 | 0.4 | 0.5 | 0.4 | 0.7 | -0.4 | 0.7 | 0.7 | 0.8 | -0.6 | 0.9 | -0.6 | 0.7 | 0.9 | 0.7 | 0.7 | 0.7 | 0.5 |
Intermittent access standard deviation | 0.4 | 0.4 | 1.0 | -1.0 | -0.2 | 0.3 | -0.6 | -0.4 | -0.8 | 0.6 | -0.8 | -0.7 | -0.8 | 0.9 | -0.7 | -0.2 | -0.0 | -0.7 | -0.7 | -0.7 | -0.1 | -0.6 |
Progressive ratio test 2 active lever presses | 0.4 | 0.5 | 0.9 | -0.3 | 0.8 | 0.8 | 0.7 | 0.9 | 0.7 | -0.5 | 0.6 | 0.6 | 0.6 | -0.6 | 0.7 | -0.8 | 0.9 | 0.7 | 0.6 | 0.6 | 0.7 | 0.8 |
Short access day 1 locomotion | 0.4 | 0.4 | 1.1 | -1.0 | -0.3 | 0.4 | -0.5 | 0.1 | -0.7 | 1.0 | -0.8 | -0.7 | -0.8 | 0.5 | -0.8 | -0.1 | 0.1 | -0.8 | -0.7 | -0.7 | -0.4 | -0.7 |
Total locomotion distance, hab. session 1 | 0.4 | 0.6 | 3.4 | 1.5 | 0.1 | -0.8 | 0.5 | -0.9 | 0.7 | -1.9 | 0.4 | 0.5 | 0.5 | -0.5 | 0.5 | 0.5 | -0.5 | 0.5 | 0.5 | 0.5 | 0.2 | 1.0 |
Locomotion velocity, hab. session 1 | 0.4 | 0.5 | 2.1 | 1.4 | 0.1 | -0.7 | 0.6 | -0.7 | 0.7 | -1.4 | 0.5 | 0.6 | 0.6 | -0.6 | 0.6 | 0.4 | -0.4 | 0.5 | 0.6 | 0.6 | 0.3 | 1.0 |
Time in familiar zone, hab. session 2 | 0.4 | 0.4 | 1.0 | 0.9 | -0.6 | -1.0 | -0.4 | -0.9 | -0.4 | -0.5 | -0.5 | -0.4 | -0.4 | 0.4 | -0.4 | 0.8 | -1.0 | -0.4 | -0.4 | -0.4 | -0.5 | -0.3 |
Pavlov. Cond. change in total contacts | 0.4 | 0.4 | 1.8 | -1.3 | 0.7 | 1.2 | 0.4 | 0.7 | -0.1 | 0.5 | 0.3 | 0.2 | 0.2 | -0.3 | 0.2 | -1.1 | 0.9 | 0.2 | 0.2 | 0.2 | 0.8 | 0.2 |
Pavlov. Cond. intertrial magazine entries | 0.4 | 0.4 | 1.5 | 1.2 | 0.1 | -0.6 | 0.5 | -0.0 | 0.7 | -1.2 | 0.7 | 0.7 | 0.7 | -0.7 | 0.7 | 0.3 | -0.1 | 0.7 | 0.7 | 0.7 | 0.1 | 0.5 |
Delta time in open arm before/after self-admin | 0.4 | 0.3 | 1.5 | 1.1 | -0.0 | -0.8 | 0.5 | -1.2 | 0.3 | -1.0 | 0.1 | 0.4 | 0.2 | -0.5 | 0.4 | 0.4 | -0.6 | 0.3 | 0.4 | 0.4 | 0.2 | 0.6 |
Sum of active levers in priming session hrs 5-6 | 0.4 | 0.4 | 1.2 | 0.4 | 0.5 | -0.1 | 0.6 | -0.9 | 0.4 | -1.1 | 0.7 | 0.5 | 0.6 | -0.5 | 0.6 | -0.3 | -0.2 | 0.6 | 0.5 | 0.5 | 0.9 | 0.9 |
Delta time to tail flick, test, before/after SA | 0.4 | 0.3 | 0.6 | -0.2 | -0.6 | -0.2 | -0.6 | -0.5 | -0.8 | 0.3 | -0.7 | -0.7 | -0.6 | 0.7 | -0.6 | 0.4 | -0.4 | -0.6 | -0.7 | -0.7 | -0.6 | -0.7 |
Delay disc. indifference point, 2s delay | 0.4 | 0.4 | 1.1 | -0.3 | -0.5 | -0.3 | -0.6 | -1.0 | -0.7 | 0.8 | -0.8 | -0.9 | -0.8 | 0.6 | -0.6 | 0.3 | -0.3 | -0.6 | -0.8 | -0.8 | -0.4 | -0.6 |
Progressive ratio | 0.4 | 0.5 | 0.9 | 0.1 | -0.7 | -0.5 | -0.4 | -0.8 | -0.8 | 0.4 | -0.8 | -0.9 | -0.5 | 0.5 | -0.4 | 0.6 | -0.8 | -0.7 | -0.9 | -0.9 | -0.7 | -0.7 |
Mg content in liver | 0.4 | 0.4 | 1.6 | 1.3 | 0.2 | -0.4 | 0.6 | 0.3 | 0.9 | -1.0 | 0.6 | 0.6 | 0.6 | -0.6 | 0.6 | 0.3 | 0.0 | 0.7 | 0.6 | 0.6 | -0.0 | 0.6 |
Left kidney weight | 0.3 | 0.7 | 2.7 | -1.6 | 0.9 | 1.6 | 0.5 | 1.5 | 0.3 | 1.0 | 0.2 | 0.2 | 0.3 | -0.4 | 0.4 | -1.4 | 1.1 | 0.2 | 0.2 | 0.2 | 0.8 | 0.4 |
Extensor digitorum longus weight | 0.3 | 1.0 | 6.1 | 2.5 | -0.3 | -1.5 | 0.3 | -0.7 | 0.8 | -2.1 | 0.7 | 0.7 | 0.6 | -0.6 | 0.6 | 1.1 | -0.8 | 0.5 | 0.7 | 0.7 | -0.2 | 0.7 |
Delay discounting water rate 6 sec | 0.3 | 0.4 | 2.4 | 1.1 | 0.2 | -0.3 | 0.7 | 0.2 | 0.7 | -1.6 | 0.4 | 0.4 | 0.7 | -0.6 | 0.5 | 0.2 | -0.1 | 0.5 | 0.3 | 0.3 | 0.1 | 0.9 |
Locomotor testing rearing | 0.3 | 0.5 | 2.0 | 1.2 | -0.6 | -0.9 | 0.3 | -1.0 | -0.2 | -1.4 | -0.7 | -0.6 | -0.3 | -0.2 | -0.2 | 0.9 | -1.1 | -0.4 | -0.6 | -0.6 | -0.6 | 0.3 |
Reaction time mean | 0.3 | 0.3 | 0.7 | 0.5 | 0.4 | 0.0 | 0.5 | 0.5 | 0.7 | -0.4 | 0.8 | 0.7 | 0.8 | -0.7 | 0.8 | -0.2 | 0.4 | 0.7 | 0.7 | 0.7 | 0.4 | 0.5 |
Reaction time mean AUC | 0.3 | 0.4 | 0.8 | 0.9 | 0.4 | -0.2 | 0.6 | 0.4 | 0.8 | -0.7 | 0.8 | 0.8 | 0.9 | -0.7 | 0.8 | 0.0 | 0.3 | 0.8 | 0.7 | 0.7 | 0.3 | 0.6 |
Median of all reaction times | 0.3 | 0.4 | 0.8 | 0.9 | 0.3 | -0.2 | 0.6 | 0.2 | 0.7 | -0.7 | 0.8 | 0.8 | 0.9 | -0.7 | 0.8 | 0.0 | 0.2 | 0.8 | 0.8 | 0.8 | 0.3 | 0.6 |
Std. dev. reaction times | 0.3 | 0.4 | 0.7 | 0.3 | -0.7 | -0.6 | -0.8 | -0.4 | -0.6 | 0.7 | -0.6 | -0.6 | -0.5 | 0.7 | -0.5 | 0.7 | -0.6 | -0.5 | -0.6 | -0.6 | -0.7 | -0.8 |
Condit. Reinf. active responses | 0.3 | 0.4 | 2.1 | 0.9 | 0.3 | -0.2 | 0.7 | 0.0 | 0.6 | -1.4 | 0.4 | 0.5 | 0.5 | -0.6 | 0.6 | 0.1 | 0.0 | 0.6 | 0.5 | 0.5 | 0.3 | 0.8 |
Conditioned reinforcement - actives | 0.3 | 0.3 | 0.7 | 0.4 | 0.4 | 0.2 | 0.8 | 0.1 | 0.7 | -0.8 | 0.2 | 0.3 | 0.4 | -0.9 | 0.5 | -0.2 | 0.2 | 0.5 | 0.3 | 0.3 | 0.2 | 0.8 |
Intermittent access day 1 total infusions | 0.3 | 0.3 | 0.6 | 0.1 | 0.6 | 0.4 | 0.5 | 0.3 | 0.6 | -0.5 | 0.8 | 0.8 | 0.5 | -0.4 | 0.5 | -0.5 | 0.5 | 0.5 | 0.8 | 0.8 | 0.5 | 0.7 |
Post-drug Anxiety | 0.3 | 0.3 | 0.9 | -0.4 | 0.7 | 0.7 | 0.6 | 0.6 | 0.3 | -0.6 | 0.3 | 0.4 | 0.3 | -0.5 | 0.5 | -0.7 | 0.6 | 0.5 | 0.4 | 0.4 | 0.9 | 0.7 |
Short access day 10 total locomotion | 0.3 | 0.3 | 1.4 | -1.2 | 0.0 | 0.7 | -0.6 | 0.6 | -0.5 | 0.9 | -0.6 | -0.5 | -0.5 | 0.4 | -0.4 | -0.4 | 0.4 | -0.4 | -0.5 | -0.5 | 0.0 | -0.6 |
One hour access (shock baseline) | 0.3 | 0.3 | 0.6 | -0.1 | 0.6 | 0.6 | 0.6 | 0.7 | 0.8 | -0.4 | 0.5 | 0.5 | 0.5 | -0.6 | 0.5 | -0.5 | 0.7 | 0.5 | 0.5 | 0.5 | 0.4 | 0.7 |
Stereotopy head waving duration, day 3 | 0.3 | 0.3 | 0.6 | -0.3 | -0.5 | -0.1 | -0.6 | -0.5 | -0.7 | -0.0 | -0.8 | -0.7 | -0.7 | 0.7 | -0.7 | 0.3 | -0.3 | -0.7 | -0.7 | -0.7 | -0.6 | -0.6 |
Bone surface | 0.3 | 0.6 | 1.3 | -0.5 | 0.8 | 0.8 | 0.6 | 1.1 | 0.6 | 0.4 | 0.8 | 0.8 | 0.7 | -0.7 | 0.7 | -0.8 | 1.0 | 0.7 | 0.8 | 0.8 | 0.7 | 0.4 |
Bone volume | 0.3 | 0.4 | 0.7 | 0.0 | 0.6 | 0.4 | 0.6 | 0.8 | 0.7 | -0.1 | 0.8 | 0.8 | 0.7 | -0.8 | 0.8 | -0.5 | 0.7 | 0.7 | 0.8 | 0.8 | 0.6 | 0.5 |
Breakpoint value in progressive ratio session | 0.3 | 0.3 | 1.0 | -0.1 | 0.7 | 0.5 | 0.8 | -0.2 | 0.4 | -1.0 | 0.4 | 0.5 | 0.4 | -0.4 | 0.6 | -0.6 | 0.4 | 0.5 | 0.5 | 0.5 | 0.9 | 0.9 |
Delta time in closed arm before/after self-admin | 0.3 | 0.3 | 2.5 | -0.5 | 0.3 | 0.7 | 0.3 | 1.6 | 0.3 | 0.4 | -0.1 | -0.3 | 0.4 | -0.1 | 0.2 | -0.4 | 0.6 | 0.3 | -0.3 | -0.3 | -0.1 | 0.1 |
Rest time, locomotor task time 1 | 0.3 | 0.4 | 0.9 | -0.9 | -0.2 | 0.3 | -0.8 | 0.1 | -0.7 | 1.0 | -0.7 | -0.6 | -0.6 | 0.6 | -0.8 | -0.1 | 0.1 | -0.7 | -0.6 | -0.6 | -0.2 | -0.7 |
Vertical activity count, locomotor time 2 | 0.3 | 0.3 | 0.9 | 0.9 | 0.2 | -0.3 | 0.6 | 0.1 | 0.7 | -0.9 | 0.4 | 0.5 | 0.6 | -0.5 | 0.8 | 0.2 | -0.1 | 0.7 | 0.5 | 0.5 | 0.1 | 0.7 |
Latency to leave start box in cocaine runway | 0.3 | 0.3 | 0.6 | 0.4 | -0.7 | -0.7 | -0.6 | -0.6 | -0.5 | 0.2 | -0.5 | -0.4 | -0.7 | 0.6 | -0.5 | 0.8 | -0.6 | -0.6 | -0.4 | -0.4 | -0.8 | -0.5 |
Mn content in liver | 0.3 | 0.4 | 0.8 | -0.6 | 0.7 | 0.9 | 0.6 | 0.9 | 0.5 | -0.2 | 0.6 | 0.6 | 0.6 | -0.6 | 0.6 | -0.8 | 0.9 | 0.6 | 0.6 | 0.6 | 0.6 | 0.4 |
Se content in liver | 0.3 | 0.4 | 0.8 | 0.4 | 0.5 | 0.2 | 0.6 | 0.6 | 0.7 | -0.9 | 0.7 | 0.7 | 0.7 | -0.6 | 0.7 | -0.3 | 0.5 | 0.7 | 0.7 | 0.7 | 0.5 | 0.7 |
Zn content in liver | 0.3 | 0.3 | 1.9 | -1.3 | 0.2 | 0.9 | -0.1 | 0.8 | -0.2 | 1.4 | -0.2 | -0.2 | -0.2 | 0.1 | -0.2 | -0.6 | 0.6 | -0.1 | -0.2 | -0.2 | 0.0 | -0.3 |
Liver weight, left | 0.2 | 0.3 | 1.6 | -1.3 | 0.1 | 0.7 | -0.4 | 0.1 | -0.6 | 0.7 | -0.4 | -0.4 | -0.5 | 0.5 | -0.4 | -0.5 | 0.3 | -0.5 | -0.4 | -0.4 | 0.1 | -0.3 |
Number of licking bursts | 0.2 | 0.3 | 0.6 | 0.2 | 0.4 | 0.3 | 0.7 | 0.7 | 0.7 | -0.1 | 0.6 | 0.6 | 0.5 | -0.5 | 0.5 | -0.3 | 0.5 | 0.5 | 0.6 | 0.6 | 0.2 | 0.6 |
Water consumed over 24 hours | 0.2 | 0.2 | 1.2 | -1.1 | 0.2 | 0.9 | -0.1 | 0.5 | -0.3 | -0.0 | -0.2 | -0.3 | -0.3 | 0.2 | -0.3 | -0.6 | 0.5 | -0.2 | -0.3 | -0.3 | 0.2 | 0.0 |
Delay discounting total patch changes 0 sec | 0.2 | 0.3 | 2.1 | 0.7 | 0.2 | -0.2 | 0.6 | -0.4 | 0.4 | -1.4 | 0.5 | 0.5 | 0.4 | -0.5 | 0.4 | 0.1 | -0.1 | 0.5 | 0.5 | 0.5 | 0.3 | 0.7 |
Reaction time mean minus median | 0.2 | 0.3 | 1.4 | -1.2 | 0.0 | 0.6 | -0.4 | 0.5 | -0.5 | 1.2 | -0.4 | -0.3 | -0.3 | 0.4 | -0.3 | -0.4 | 0.4 | -0.4 | -0.3 | -0.3 | -0.0 | -0.7 |
Reaction time mean minus median AUC | 0.2 | 0.2 | 1.0 | -0.9 | 0.4 | 0.8 | 0.3 | 1.0 | 0.2 | 0.7 | 0.0 | 0.0 | 0.2 | -0.3 | 0.2 | -0.7 | 0.7 | 0.1 | 0.0 | 0.0 | 0.3 | 0.0 |
Reaction time omissions | 0.2 | 0.3 | 0.8 | 0.6 | 0.5 | -0.0 | 0.7 | 0.3 | 0.7 | -0.5 | 0.4 | 0.5 | 0.7 | -0.8 | 0.9 | -0.2 | 0.1 | 0.9 | 0.5 | 0.5 | 0.4 | 0.8 |
Lifetime Intake | 0.2 | 0.2 | 0.3 | -0.0 | 0.4 | 0.4 | 0.3 | 0.3 | 0.5 | -0.4 | 0.5 | 0.5 | 0.5 | -0.3 | 0.5 | -0.4 | 0.5 | 0.5 | 0.5 | 0.5 | 0.4 | 0.6 |
Total sessions with >9 infusions | 0.2 | 0.2 | 0.6 | -0.1 | -0.5 | -0.1 | -0.8 | 0.1 | -0.5 | 0.5 | -0.5 | -0.5 | -0.3 | 0.6 | -0.3 | 0.4 | -0.0 | -0.3 | -0.5 | -0.5 | -0.7 | -0.6 |
Stereotopy head waving bouts, day 7 | 0.2 | 0.2 | 1.0 | 0.3 | 0.4 | 0.2 | 0.6 | -0.1 | 0.5 | -1.0 | 0.6 | 0.5 | 0.5 | -0.5 | 0.5 | -0.3 | 0.2 | 0.5 | 0.5 | 0.5 | 0.5 | 0.6 |
Active lever presses in extinction session 6 | 0.2 | 0.2 | 0.5 | -0.3 | 0.0 | 0.2 | 0.1 | -0.5 | -0.4 | -0.5 | -0.7 | -0.7 | -0.2 | 0.2 | -0.2 | -0.1 | -0.4 | -0.2 | -0.7 | -0.7 | 0.2 | 0.3 |
Time in open arm before self-admin | 0.2 | 0.2 | 1.6 | -0.3 | 0.2 | 0.5 | 0.5 | 1.3 | 0.3 | 0.1 | -0.3 | -0.3 | 0.3 | -0.2 | 0.3 | -0.3 | 0.4 | 0.3 | -0.3 | -0.3 | -0.1 | 0.2 |
Time in open arm after self-admin | 0.2 | 0.2 | 0.8 | 0.9 | -0.2 | -0.6 | 0.5 | -0.7 | 0.2 | -0.6 | -0.2 | 0.0 | -0.0 | -0.2 | 0.2 | 0.5 | -0.6 | 0.0 | 0.0 | 0.0 | -0.2 | 0.4 |
Delta time to tail flick, vehicle, before/after SA | 0.2 | 0.2 | 0.4 | 0.5 | -0.6 | -0.6 | -0.3 | -0.5 | -0.3 | -0.2 | -0.5 | -0.6 | -0.3 | 0.2 | -0.3 | 0.6 | -0.6 | -0.3 | -0.6 | -0.6 | -0.7 | -0.1 |
Locomotion in novel chamber | 0.2 | 0.2 | 0.6 | 0.8 | -0.4 | -0.6 | 0.3 | -0.6 | -0.0 | -0.4 | -0.2 | -0.4 | -0.0 | 0.0 | -0.1 | 0.6 | -0.8 | 0.0 | -0.5 | -0.5 | -0.4 | 0.1 |
Food seeking constrained by brief footshock | 0.2 | 0.2 | 0.4 | -0.4 | -0.3 | -0.0 | -0.5 | -0.4 | -0.6 | 0.1 | -0.6 | -0.6 | -0.6 | 0.4 | -0.6 | 0.2 | -0.3 | -0.6 | -0.6 | -0.6 | -0.2 | -0.3 |
Latency to leave start box in cocaine runway, F | 0.2 | 0.3 | 0.9 | 0.9 | -0.6 | -0.9 | -0.3 | -0.6 | -0.2 | -0.2 | -0.3 | -0.3 | -0.3 | 0.3 | -0.2 | 0.9 | -0.8 | -0.3 | -0.3 | -0.3 | -0.8 | -0.1 |
Right kidney weight | 0.1 | 0.3 | 1.3 | -1.1 | 0.5 | 1.1 | 0.3 | 1.1 | 0.2 | 0.6 | -0.1 | -0.1 | 0.1 | -0.2 | -0.0 | -0.8 | 0.7 | -0.1 | -0.1 | -0.1 | 0.3 | 0.4 |
Mean num. licks in bursts | 0.1 | 0.2 | 0.6 | -0.6 | 0.5 | 0.6 | 0.1 | 0.2 | 0.0 | -0.8 | 0.1 | 0.1 | 0.2 | -0.3 | 0.2 | -0.6 | 0.4 | 0.3 | 0.1 | 0.1 | 0.7 | 0.4 |
Indifference point 0 sec | 0.1 | 0.2 | 1.2 | 0.3 | 0.4 | 0.1 | 0.5 | -0.2 | 0.4 | -1.1 | 0.5 | 0.5 | 0.4 | -0.4 | 0.3 | -0.2 | 0.1 | 0.4 | 0.5 | 0.5 | 0.4 | 0.7 |
Social time | 0.1 | 0.1 | 0.5 | 0.7 | -0.4 | -0.6 | -0.2 | -0.4 | -0.1 | -0.6 | -0.2 | -0.2 | -0.1 | 0.0 | -0.3 | 0.6 | -0.4 | -0.3 | -0.1 | -0.1 | -0.4 | -0.0 |
Cocaine response after cond. corrected | 0.1 | 0.1 | 0.5 | -0.2 | -0.3 | -0.2 | -0.4 | -0.7 | -0.5 | 0.1 | -0.4 | -0.4 | -0.3 | 0.4 | -0.3 | 0.2 | -0.4 | -0.4 | -0.4 | -0.4 | -0.1 | -0.3 |
Incentive Sensitization - Responses | 0.1 | 0.1 | 0.5 | -0.3 | 0.4 | 0.4 | 0.1 | 0.7 | 0.3 | 0.1 | 0.3 | 0.4 | 0.3 | -0.2 | 0.3 | -0.4 | 0.5 | 0.3 | 0.4 | 0.4 | 0.3 | 0.1 |
Incentive Sensitization - Breakpoint | 0.1 | 0.1 | 0.4 | -0.4 | 0.4 | 0.5 | 0.1 | 0.6 | 0.2 | 0.1 | 0.2 | 0.3 | 0.2 | -0.2 | 0.2 | -0.4 | 0.5 | 0.2 | 0.3 | 0.3 | 0.3 | 0.1 |
Short access day 1 total inactive lever presses | 0.1 | 0.1 | 0.4 | 0.3 | 0.2 | 0.0 | 0.4 | 0.4 | 0.6 | -0.3 | 0.1 | 0.1 | 0.5 | -0.3 | 0.5 | -0.1 | -0.0 | 0.5 | 0.1 | 0.1 | 0.1 | 0.6 |
Condit. Reinf. lever presses | 0.1 | 0.1 | 0.3 | 0.6 | 0.1 | -0.2 | 0.4 | 0.1 | 0.4 | -0.6 | 0.3 | 0.2 | 0.2 | -0.3 | 0.2 | 0.1 | -0.1 | 0.3 | 0.2 | 0.2 | 0.0 | 0.4 |
Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.2 | -0.0 | -0.2 | -0.2 | -0.4 | -0.3 | -0.4 | -0.4 | -0.3 | -0.3 | -0.3 | 0.3 | -0.3 | 0.2 | -0.2 | -0.3 | -0.3 | -0.3 | -0.1 | -0.2 |
Time in novel zone, hab. session 2 | 0.1 | 0.1 | 0.1 | -0.3 | -0.2 | 0.2 | -0.3 | 0.1 | -0.2 | 0.4 | -0.2 | -0.2 | -0.2 | 0.2 | -0.2 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | -0.3 | -0.3 |
Bone: apparent density | 0.1 | 0.2 | 0.5 | 0.5 | 0.3 | -0.1 | 0.5 | 0.4 | 0.6 | -0.3 | 0.6 | 0.7 | 0.5 | -0.6 | 0.6 | -0.1 | 0.3 | 0.6 | 0.7 | 0.7 | 0.3 | 0.3 |
Bone: endosteal estimation | 0.1 | 0.2 | 1.7 | 1.3 | -0.3 | -1.0 | 0.2 | -0.4 | 0.4 | -0.3 | 0.2 | 0.3 | 0.2 | -0.2 | 0.2 | 0.7 | -0.6 | 0.2 | 0.3 | 0.3 | -0.2 | 0.1 |
Bone: marrow area | 0.1 | 0.2 | 1.7 | 1.3 | -0.3 | -1.0 | 0.1 | -0.5 | 0.3 | -0.4 | 0.2 | 0.2 | 0.2 | -0.2 | 0.2 | 0.7 | -0.6 | 0.2 | 0.2 | 0.2 | -0.2 | 0.1 |
Bone: post-yield work | 0.1 | 0.1 | 0.8 | 0.9 | -0.2 | -0.6 | 0.0 | -0.4 | 0.2 | -0.5 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | 0.5 | -0.5 | 0.0 | 0.0 | 0.0 | -0.3 | 0.1 |
Diff in mean of infusions in LGA sessions | 0.1 | 0.1 | 0.4 | -0.1 | -0.3 | -0.1 | -0.0 | -0.4 | -0.4 | 0.1 | -0.6 | -0.5 | -0.5 | 0.3 | -0.4 | 0.2 | -0.3 | -0.5 | -0.5 | -0.5 | -0.2 | -0.1 |
Time to tail flick, vehicle, before self-admin | 0.1 | 0.1 | 0.2 | 0.1 | 0.3 | 0.2 | 0.4 | 0.3 | 0.4 | -0.0 | 0.4 | 0.4 | 0.4 | -0.2 | 0.3 | -0.2 | 0.2 | 0.2 | 0.4 | 0.4 | 0.2 | 0.2 |
Time to tail flick, test, before self-admin | 0.1 | 0.1 | 0.4 | -0.6 | 0.2 | 0.5 | -0.1 | 0.5 | -0.1 | 0.4 | -0.1 | -0.1 | 0.2 | 0.0 | 0.0 | -0.4 | 0.4 | -0.0 | -0.1 | -0.1 | 0.2 | -0.2 |
Time to tail flick, test, after self-admin | 0.1 | 0.1 | 0.5 | -0.3 | -0.2 | 0.2 | -0.1 | 0.4 | -0.3 | 0.2 | -0.6 | -0.7 | -0.1 | 0.3 | -0.1 | 0.1 | -0.1 | -0.1 | -0.7 | -0.7 | -0.4 | -0.2 |
Total heroin consumption | 0.1 | 0.1 | 0.4 | -0.5 | 0.4 | 0.5 | 0.2 | -0.3 | 0.0 | -0.4 | -0.2 | -0.0 | 0.0 | -0.3 | 0.4 | -0.5 | 0.2 | 0.2 | -0.0 | -0.0 | 0.6 | 0.5 |
Time >=10cm from walls, locomotor time 2 | 0.1 | 0.1 | 0.4 | -0.5 | 0.2 | 0.6 | 0.0 | 0.4 | 0.1 | 0.2 | 0.2 | 0.1 | -0.0 | 0.2 | -0.0 | -0.3 | 0.6 | -0.1 | 0.1 | 0.1 | -0.1 | -0.0 |
Rest time, locomotor task time 2 | 0.1 | 0.2 | 0.5 | -0.4 | -0.2 | 0.1 | -0.6 | 0.4 | -0.4 | 0.7 | -0.3 | -0.2 | -0.4 | 0.4 | -0.7 | 0.1 | 0.1 | -0.6 | -0.2 | -0.2 | -0.3 | -0.6 |
Distance moved, locomotor task time 2 | 0.1 | 0.1 | 0.3 | -0.1 | 0.3 | 0.3 | 0.5 | 0.0 | 0.4 | -0.0 | 0.2 | 0.2 | 0.3 | -0.3 | 0.4 | -0.3 | 0.2 | 0.4 | 0.2 | 0.2 | 0.3 | 0.5 |
Seeking ratio, punishment vs. effort | 0.1 | 0.1 | 0.3 | 0.3 | 0.3 | 0.1 | 0.2 | 0.2 | 0.5 | -0.5 | 0.5 | 0.6 | 0.3 | -0.3 | 0.2 | -0.2 | 0.3 | 0.4 | 0.6 | 0.6 | 0.4 | 0.5 |
Latency to leave start box in cocaine runway, M | 0.1 | 0.0 | 0.1 | -0.3 | 0.0 | 0.2 | -0.2 | 0.4 | -0.2 | 0.3 | 0.0 | 0.2 | -0.3 | 0.2 | -0.3 | -0.1 | 0.3 | -0.2 | 0.0 | 0.0 | 0.0 | -0.3 |
Co content in liver | 0.1 | 0.2 | 0.5 | 0.6 | -0.4 | -0.5 | -0.2 | -0.6 | -0.2 | -0.7 | -0.3 | -0.3 | -0.3 | 0.2 | -0.3 | 0.5 | -0.5 | -0.3 | -0.3 | -0.3 | -0.3 | -0.1 |
Na content in liver | 0.1 | 0.1 | 0.3 | -0.5 | 0.3 | 0.4 | 0.1 | 0.5 | 0.1 | 0.2 | 0.1 | 0.1 | 0.1 | -0.2 | 0.1 | -0.4 | 0.4 | 0.2 | 0.1 | 0.1 | 0.2 | 0.1 |
Tibialis anterior weight | 0.0 | 0.1 | 0.5 | 0.7 | -0.1 | -0.5 | 0.1 | 0.2 | 0.4 | 0.1 | 0.3 | 0.3 | 0.3 | -0.4 | 0.3 | 0.3 | -0.1 | 0.3 | 0.3 | 0.3 | -0.2 | -0.2 |
Indifference point AUC | 0.0 | 0.0 | 0.1 | 0.2 | -0.1 | -0.2 | 0.1 | -0.3 | -0.0 | -0.2 | -0.2 | -0.1 | -0.1 | -0.0 | -0.1 | 0.2 | -0.2 | -0.1 | -0.2 | -0.2 | -0.1 | 0.1 |
Delay discounting total patch changes 12 sec | 0.0 | 0.0 | 0.2 | -0.2 | 0.1 | 0.2 | 0.1 | -0.2 | -0.1 | -0.4 | -0.1 | 0.1 | -0.0 | -0.0 | -0.1 | -0.2 | 0.1 | -0.0 | 0.0 | 0.0 | 0.2 | 0.2 |
Social responses | 0.0 | 0.1 | 0.2 | 0.5 | -0.2 | -0.3 | 0.1 | -0.0 | 0.1 | -0.4 | -0.1 | -0.1 | -0.1 | 0.0 | -0.1 | 0.3 | -0.3 | -0.1 | -0.1 | -0.1 | -0.3 | 0.3 |
Short access total infusions | 0.0 | 0.0 | 0.1 | -0.1 | -0.0 | 0.1 | -0.2 | -0.0 | -0.1 | -0.0 | 0.0 | 0.0 | -0.1 | 0.2 | -0.0 | -0.0 | 0.1 | -0.0 | 0.0 | 0.0 | -0.1 | 0.0 |
Time in novel zone, hab. session 1 | 0.0 | 0.0 | 0.1 | 0.2 | 0.1 | -0.0 | 0.2 | 0.0 | 0.3 | -0.3 | 0.1 | 0.2 | 0.2 | -0.2 | 0.2 | 0.0 | 0.1 | 0.2 | 0.2 | 0.2 | 0.0 | 0.2 |
Bone: connectivity density | 0.0 | 0.1 | 0.5 | 0.7 | -0.3 | -0.4 | -0.1 | 0.1 | 0.2 | -0.1 | 0.1 | 0.1 | 0.0 | -0.1 | 0.1 | 0.5 | -0.1 | 0.1 | 0.1 | 0.1 | -0.4 | -0.2 |
Bone: trabecular number | 0.0 | 0.0 | 0.5 | -0.1 | -0.0 | 0.0 | -0.0 | 0.5 | 0.0 | 0.7 | 0.0 | 0.1 | 0.1 | -0.1 | 0.1 | -0.0 | 0.2 | 0.1 | 0.1 | 0.1 | -0.1 | -0.3 |
Delay disc. indifference point, 0s delay | 0.0 | 0.0 | 0.6 | -0.0 | 0.0 | 0.0 | 0.2 | -0.8 | 0.1 | 0.0 | -0.2 | -0.2 | -0.1 | -0.2 | 0.0 | -0.1 | 0.1 | 0.0 | -0.2 | -0.2 | 0.1 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.