Nedd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	ENSRNOG00000004011	0.07	0.04	6.2e-08	0.05	0.05	0.03	0.04	2.7e-06	1.4e-06	2.5e-04	1.0e-05
2	Brain	mRNA stability	ENSRNOG00000004011	0.07	0.04	1.5e-05	0.03	0.04	0.03	0.02	3.8e-04	1.2e-04	2.2e-03	2.7e-03
3	Liver	gene expression	ENSRNOG00000004011	0.2	0.08	0.0e+00	0.24	0.23	0.21	0.24	8.6e-27	1.7e-25	5.7e-23	3.2e-26
4	Liver	mRNA stability	ENSRNOG00000004011	0.04	0.03	8.1e-05	0.02	0.03	0.02	0.02	6.0e-03	7.8e-04	1.6e-03	1.1e-03
5	PL	gene expression	ENSRNOG00000004011	0.14	0.07	4.5e-09	0.11	0.1	0.1	0.1	7.3e-09	4.5e-08	9.7e-08	5.5e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
BMI with tail	0.9	2.9	3.7	-1.7	-1.9	-1.3	-1.9	1.5
BMI without tail	1.1	2.4	3.0	-1.7	-1.5	-1.6	-1.7	1.0
Body weight	3.9	16.6	25.0	-4.8	-3.4	-5.0	-4.6	1.4
Epididymis fat weight	2.4	5.6	9.4	-2.8	-1.7	-3.1	-2.8	0.6
Glucose	0.1	0.1	0.2	-0.2	-0.3	-0.2	-0.3	0.5
Heart weight	0.1	0.1	0.3	-0.4	-0.1	-0.5	-0.3	-0.4
Left kidney weight	1.5	4.4	6.6	-2.6	-1.7	-2.6	-2.4	0.7
Right kidney weight	1.4	4.1	7.1	-2.5	-1.4	-2.7	-2.3	0.2
Tail length	3.4	10.2	19.0	-3.9	-2.2	-4.4	-3.5	0.2
Length with tail	5.2	18.9	38.3	-5.2	-2.7	-6.2	-4.6	-0.2
Length without tail	3.2	7.0	14.6	-3.1	-1.6	-3.8	-2.8	-0.3
Liver weight, left	0.3	0.4	1.0	-0.5	0.2	-1.0	-0.3	-0.8
Liver weight, right	3.3	5.4	7.1	-2.6	-2.5	-1.9	-2.7	1.8
Parametrial fat weight	0.1	0.1	0.2	-0.4	-0.3	-0.4	-0.4	0.3
Retroperitoneal fat weight	1.5	5.1	6.7	-2.6	-2.0	-2.4	-2.6	1.5
Intraocular pressure	1.7	2.3	3.1	1.5	1.7	1.2	1.4	-1.7
Extensor digitorum longus weight	0.7	2.6	8.3	-0.7	-1.8	0.6	-0.8	2.9
Soleus weight	0.8	2.2	3.0	-1.7	-1.6	-1.0	-1.7	1.2
Tibialis anterior weight	0.8	2.8	9.4	-0.1	-1.6	1.3	-0.2	3.1
Tibia length	7.1	19.9	28.1	-5.1	-4.0	-5.3	-5.0	2.0
Number of licking bursts	0.4	0.5	0.7	-0.7	-0.8	-0.2	-0.8	0.7
Food consumed during 24 hour testing period	0.9	1.1	3.0	0.5	1.2	-0.4	0.7	-1.7
Times rat made contact with spout	0.7	0.8	1.9	1.1	0.3	1.4	0.8	0.4
Mean time between licks in bursts	1.2	1.7	3.6	-1.0	-1.5	-0.2	-1.2	1.9
Mean num. licks in bursts	1.8	2.2	3.4	1.8	1.4	1.6	1.8	-0.6
Std. dev. time between licks in bursts	0.7	0.9	1.1	-1.0	-1.1	-0.7	-1.0	1.0
Water consumed over 24 hours	0.2	0.2	0.7	-0.0	0.3	-0.4	-0.0	-0.9
Indifference point 0 sec	0.1	0.2	0.3	0.3	0.6	0.2	0.6	-0.4
Indifference point AUC	0.1	0.2	0.5	0.0	0.5	-0.1	0.2	-0.7
Indifference point function ln k	0.0	0.0	0.0	0.2	0.1	-0.1	0.2	-0.2
Indifference point function log k	0.0	0.0	0.0	0.2	0.1	-0.1	0.2	-0.2
Delay discounting total patch changes 0 sec	0.1	0.1	0.2	0.1	0.5	-0.0	0.4	-0.4
Delay discounting total patch changes 12 sec	0.2	0.3	0.7	-0.8	-0.1	-0.8	-0.5	0.0
Delay discounting total patch changes 18 sec	0.1	0.1	0.1	-0.1	0.4	-0.3	0.1	-0.4
Delay discounting total patch changes 24 sec	0.2	0.3	0.7	0.3	0.8	0.1	0.6	-0.6
Delay discounting total patch changes 6 sec	0.4	0.6	1.1	0.8	0.7	1.0	0.9	0.1
Delay discounting time to switch 0 sec	0.6	0.9	2.5	-0.6	-1.2	-0.1	-0.7	1.6
Delay discounting water rate 0 sec	0.3	0.4	0.6	-0.6	-0.7	-0.5	-0.8	0.5
Delay discounting water rate 12 sec	0.0	0.1	0.2	0.1	0.4	-0.1	0.1	-0.4
Delay discounting water rate 18 sec	0.6	0.7	1.5	-0.6	-1.0	-0.3	-0.8	1.2
Delay discounting water rate 24 sec	1.9	2.7	3.7	-1.8	-1.7	-1.5	-1.9	1.2
Delay discounting water rate 6 sec	4.0	5.8	8.1	-2.7	-2.5	-2.4	-2.9	1.3
Locomotor activity	1.2	1.9	2.4	-1.5	-1.4	-1.3	-1.4	1.3
Locomotor testing distance	0.2	0.3	1.1	-0.2	-0.6	0.1	-0.2	1.1
Locomotor testing rearing	0.3	0.5	1.0	0.4	-0.2	1.0	0.4	1.0
Light reinforcement 1	1.8	3.4	5.4	-2.2	-1.3	-2.3	-2.1	0.4
Light reinforcement 2	0.1	0.2	0.4	0.3	0.6	0.1	0.2	-0.6
Reaction time number correct	0.0	0.0	0.2	0.0	0.0	-0.1	-0.0	-0.4
Reaction time mean minus median	0.3	0.4	1.0	0.7	0.4	1.0	0.7	0.2
Reaction time mean minus median AUC	0.9	1.1	2.1	1.2	0.8	1.4	1.2	-0.2
Reaction time num false alarms	1.9	2.6	3.5	1.7	1.8	1.1	1.9	-1.4
Reaction time num false alarms AUC	2.4	3.4	4.6	2.0	2.1	1.4	2.2	-1.5
Reaction time trials correct on left	0.0	0.0	0.2	0.0	0.0	-0.1	-0.0	-0.4
Reaction time trials on left	0.0	0.0	0.2	0.1	0.0	-0.0	0.0	-0.4
Reaction time mean	0.5	0.7	2.1	-0.3	-0.9	0.5	-0.4	1.5
Reaction time mean AUC	0.4	0.6	1.8	-0.2	-0.8	0.6	-0.3	1.4
Median of all reaction times	0.9	1.2	3.0	-0.6	-1.3	0.2	-0.8	1.7
Reaction time omissions	1.1	1.5	3.8	1.3	0.6	2.0	1.2	0.4
Reaction time false alarm rate	1.7	2.4	3.5	1.8	1.6	1.4	1.9	-0.8
Reaction time premature initiation rate	3.7	4.9	7.3	-2.0	-2.7	-1.2	-2.2	2.7
Reaction time premature initiations	2.4	3.4	5.0	-1.8	-2.2	-1.3	-1.9	1.9
Std. dev. reaction times	0.3	0.4	0.8	0.3	-0.2	0.9	0.3	0.9
Reaction time trials completed	0.0	0.0	0.2	0.1	0.0	-0.0	0.0	-0.4
Reaction time trials AUC	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.2	-0.2
Social response proportion	4.4	4.7	6.0	-2.3	-2.4	-2.0	-2.5	1.6
Social responses	2.7	3.5	5.9	-1.6	-2.2	-1.0	-1.8	2.4
Social time	0.4	0.5	1.3	0.2	-0.7	0.8	0.0	1.2
Conditioned locomotion	0.8	1.0	2.1	-0.9	-1.1	-0.4	-0.9	1.4
Cocaine response after cond. corrected	1.3	1.5	4.9	0.5	1.4	-0.3	0.7	-2.2
Cocaine response after cond. not corrected	1.4	1.5	4.5	0.7	1.4	-0.1	0.8	-2.1
Cocaine response before conditioning	0.3	0.3	0.7	0.5	-0.2	0.7	0.3	0.8
Saline control response	0.2	0.2	0.3	0.5	0.6	0.3	0.5	-0.5
Condit. Reinf. active minus inactive responses	0.4	0.5	1.3	-0.5	-0.8	-0.1	-0.5	1.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.2	-0.2	-0.1	-0.1	0.2
Condit. Reinf. active responses	1.0	1.3	3.2	-0.9	-1.4	-0.2	-1.0	1.8
Condit. Reinf. inactive responses	0.5	0.6	1.4	-0.6	-1.0	-0.1	-0.7	1.2
Condit. Reinf. lever presses	0.7	0.9	1.8	-1.2	-0.7	-1.3	-1.0	0.3
Condit. Reinf. lever reinforcers received	0.9	1.2	2.7	-0.9	-1.3	-0.3	-0.9	1.6
Pavlov. Cond. lever latency	0.2	0.3	1.0	0.5	0.1	1.0	0.4	0.2
Pavlov. Cond. magazine entry latency	0.5	0.5	0.7	-0.8	-0.8	-0.6	-0.8	0.6
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	-0.5	-0.4	-0.8	-0.5	0.3
Pavlov. Cond. index score	0.5	0.7	1.3	-0.9	-0.7	-1.1	-0.8	0.4
Pavlov. Cond. latency score	0.3	0.3	0.7	-0.6	-0.5	-0.8	-0.6	0.2
Pavlov. Cond. lever contacts	0.6	0.8	2.0	-1.0	-0.5	-1.4	-0.9	0.1
Pavlov. Cond. magazine entry number	1.1	1.4	1.8	1.2	1.3	0.9	1.3	-1.1
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.3	-1.1	-0.8	-1.0	-0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	-0.8	-0.6	-1.0	-0.8	0.3
Pavlov. Cond. response bias	1.1	1.5	2.7	-1.4	-1.0	-1.6	-1.3	0.4
Conditioned reinforcement - actives	0.3	0.3	0.6	-0.1	-0.8	0.3	-0.2	0.8
Conditioned reinforcement - inactives	0.6	0.7	1.7	0.6	0.9	0.4	0.8	-1.3
Conditioned locomotion	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.2	-0.1
Intermittent access intake day 1-15 change	0.3	0.3	0.6	0.1	-0.6	0.6	0.0	0.8
Intermittent access intake escalation	0.1	0.1	0.2	0.3	-0.1	0.5	0.2	0.3
Intermittent access intake escalation 2	0.3	0.3	0.5	0.7	-0.0	0.7	0.6	0.2
Intermitt. access day 1 inactive lever presses	10.0	10.8	13.6	3.4	3.7	2.6	3.5	-3.2
Intermitt. access day 15 inactive lever presses	4.1	4.5	7.3	2.0	2.7	1.1	2.1	-2.4
Intermitt. access escalation Index	0.0	0.0	0.0	0.1	0.2	0.1	0.1	-0.1
Intermittent access day 1 total infusions	0.7	0.8	1.0	1.0	0.9	0.8	0.8	-0.9
Intermittent access day 15 total infusions	0.4	0.4	0.8	0.8	0.4	0.9	0.5	-0.4
Intermittent access terminal intake (last 3 days)	0.4	0.4	0.9	0.8	0.3	0.9	0.6	-0.3
Intermittent access total infusions	0.8	0.9	1.4	1.2	0.7	1.1	0.9	-0.7
Intermittent access day 1 locomotion	0.9	0.9	2.8	0.5	1.0	-0.1	0.5	-1.7
Intermittent access day 15 total locomotion	0.3	0.3	0.5	0.5	0.5	0.4	0.5	-0.7
Intermittent access total locomotion	0.6	0.7	1.3	0.8	0.8	0.6	0.8	-1.1
Intermittent access standard deviation	0.2	0.2	0.3	0.5	0.1	0.5	0.2	-0.5
Cocaine induced anxiety	0.6	0.7	1.5	-0.7	0.3	-1.2	-0.5	-1.1
Post-drug Anxiety	0.4	0.5	1.2	-0.7	-0.1	-1.1	-0.7	-0.4
Baseline Anxiety	0.2	0.3	0.9	0.0	-0.5	0.4	-0.0	1.0
Lifetime Intake	0.0	0.0	0.1	0.3	-0.1	0.3	0.0	-0.1
Incentive Sensitization - Responses	0.3	0.3	0.5	0.7	0.5	0.3	0.6	-0.6
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	0.7	0.5	0.3	0.6	-0.6
Progressive ratio test 1 active lever presses	0.3	0.4	1.1	0.5	0.5	0.2	0.3	-1.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.5	0.2	0.1	0.2	0.0	-0.7
Progressive ratio test 1 inactive lever presses	1.6	1.7	2.5	1.3	1.4	0.8	1.3	-1.6
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	0.5	0.1	0.4	0.2	-0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.4	0.0	0.4	0.2	-0.1
Progressive ratio test 2 inactive lever presses	2.6	3.0	4.1	2.0	1.7	1.8	1.8	-1.2
Total sessions with >9 infusions	0.1	0.1	0.3	0.2	-0.0	-0.0	-0.0	-0.6
Short access day 1 total inactive lever presses	3.9	4.4	5.1	2.3	2.2	1.8	2.2	-1.9
Short access day 10 total inactive lever presses	1.9	2.1	3.2	1.3	1.8	0.6	1.6	-1.7
Short access day 1 total infusions	0.9	0.9	1.8	-0.8	-1.3	-0.3	-1.1	1.0
Short access day 10 total infusions	0.5	0.5	0.9	0.7	0.7	0.4	0.7	-1.0
Short access total infusions	0.8	0.9	1.5	-0.8	-1.2	-0.5	-1.1	0.8
Short access day 1 locomotion	0.0	0.0	0.1	0.1	0.1	0.1	-0.0	-0.3
Short access day 10 total locomotion	0.2	0.2	0.5	0.5	0.3	0.4	0.3	-0.7
Short access total locomotion	0.4	0.4	1.3	0.4	0.5	0.1	0.3	-1.1
Compulsive drug intake	0.5	0.5	0.6	-0.8	-0.7	-0.7	-0.7	0.8
One hour access (0.3 mA shock)	0.1	0.2	0.3	0.3	-0.5	0.5	-0.1	0.5
One hour access (shock baseline)	0.3	0.4	0.7	0.8	0.4	0.7	0.6	-0.4
Number of responses in last shaping day	1.1	1.1	1.4	1.2	1.1	0.8	1.2	-0.9
Context. condit. distance diff. score	0.7	0.9	1.4	-1.1	-0.7	-1.2	-1.0	0.5
Locomotion velocity, session 1	1.6	1.7	2.0	1.4	1.4	1.2	1.4	-1.2
Locomotion distance, session 1	0.2	0.3	0.4	0.6	0.5	0.5	0.6	-0.4
Locomotion velocity, session 2	0.3	0.4	1.2	0.2	0.7	-0.3	0.2	-1.1
Locomotion distance, session 2	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	0.1
Locomotion velocity, session 3	0.2	0.3	0.4	-0.7	-0.4	-0.6	-0.6	0.1
Locomotion distance, session 3	1.9	2.1	3.3	-1.6	-1.2	-1.8	-1.7	0.5
Stereotopy head waving bouts, day 3	0.8	0.9	2.7	1.0	0.1	1.6	0.7	0.7
Stereotopy head waving duration, day 3	1.1	1.3	2.9	1.3	0.7	1.7	1.2	0.1
Locomotion velocity, session 7	0.3	0.4	1.2	-0.3	0.2	-1.1	-0.3	-0.7
Locomotion distance, session 7	0.3	0.4	1.1	-0.1	0.5	-0.9	-0.1	-1.0
Stereotopy head waving bouts, day 7	0.4	0.5	1.4	0.2	0.8	-0.4	0.4	-1.2
Stereotopy head waving duration, day 7	0.2	0.2	0.7	0.1	0.6	-0.4	0.2	-0.9
Locomotion velocity, session 8	0.3	0.4	1.2	0.0	0.6	-0.4	0.1	-1.1
Locomotion distance, session 8	1.3	1.9	2.6	-1.5	-1.3	-1.5	-1.6	0.8
Degree of sensitization distance	1.8	1.8	2.3	1.4	1.5	0.9	1.4	-1.4
Degree of sensitization stereotypy	0.6	0.6	1.9	-0.0	0.8	-0.8	0.2	-1.4
Condit. Reinf. active minus inactive responses	2.0	2.2	5.2	1.7	0.5	2.3	1.4	0.7
Condit. Reinf. active-inactive response ratio	1.5	1.6	3.9	1.3	0.2	2.0	1.1	1.0
Condit. Reinf. active responses	4.8	5.8	10.9	2.9	1.7	3.3	2.6	-0.3
Condit. Reinf. inactive responses	2.8	3.3	4.1	2.0	1.8	1.8	1.9	-1.4
Incentive salience index mean	1.6	1.9	5.0	1.6	0.4	2.2	1.3	0.6
Condit. Reinf. lever presses	0.2	0.3	0.9	0.5	-0.2	1.0	0.2	0.4
Time in familiar zone, hab. session 1	0.2	0.2	0.5	-0.4	0.1	-0.7	-0.3	-0.5
Time in novel zone, hab. session 1	0.2	0.1	0.5	0.2	-0.3	0.4	0.1	0.7
Total zone transitions, hab. session 1	1.5	2.1	5.9	-0.8	-1.7	0.1	-1.1	2.4
Total locomotion distance, hab. session 1	1.5	2.1	7.0	-0.3	-1.6	0.7	-0.8	2.6
Locomotion velocity, hab. session 1	1.7	2.4	7.9	-0.1	-1.6	1.1	-0.6	2.8
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.0	-0.0	0.0	-0.1	0.3
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.4	0.2	0.5	0.5	-0.2
Total zone transitions, hab. session 2	1.1	1.4	3.2	-0.7	-1.5	0.1	-1.0	1.8
Total locomotion distance, hab. session 2	1.8	2.4	7.6	-0.2	-1.7	1.1	-0.7	2.8
Locomotion velocity, hab. session 2	1.8	2.4	7.5	-0.3	-1.7	1.0	-0.8	2.7
Novel to familiar place preference ratio	2.4	2.5	5.6	1.1	2.0	0.2	1.4	-2.4
Novelty place preference	2.7	2.8	6.0	1.2	2.1	0.2	1.5	-2.4
Time in novel zone, NPP test	2.2	2.4	5.1	1.1	1.9	0.1	1.3	-2.3
Total zone transitions, NPP test	0.5	0.7	0.9	-0.9	-0.9	-0.6	-0.9	0.8
Total locomotion distance, NPP test	0.5	0.7	2.1	0.1	-0.7	0.8	-0.2	1.4
Locomotion velocity, NPP test	0.5	0.7	2.0	0.4	-0.6	1.1	0.1	1.4
Pavlov. Cond. lever latency	0.4	0.6	1.2	-0.9	-0.3	-1.1	-0.8	-0.1
Pavlov. Cond. magazine entry latency	1.2	1.6	3.8	-0.8	-1.5	-0.1	-1.1	1.9
Pavlov. Cond. change in total contacts	0.3	0.3	1.1	0.2	-0.6	0.5	-0.1	1.0
Pavlov. Cond. index score	0.1	0.2	0.4	0.1	-0.5	0.4	-0.1	0.7
Pavlov. Cond. latency score	0.1	0.2	0.3	0.3	-0.3	0.6	0.1	0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.5	0.6	0.2	0.7	0.5	-0.0
Pavlov. Cond. magazine entry number	1.4	1.8	3.4	1.0	1.6	0.5	1.2	-1.9
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.6	0.7	0.7	0.5	0.8	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.0	-0.6	0.3	-0.3	0.9
Pavlov. Cond. response bias	0.4	0.4	1.4	0.0	-0.7	0.5	-0.3	1.2
Bone: apparent density	0.4	0.7	1.4	-0.6	-1.1	-0.1	-0.6	1.2
Bone surface	0.2	0.3	0.8	0.0	-0.4	0.6	-0.0	0.9
Bone volume	0.6	1.0	2.4	-0.7	-1.2	-0.0	-0.7	1.6
Bone: connectivity density	0.1	0.2	0.3	0.4	0.5	0.5	0.5	-0.5
Bone: cortical apparent density	3.0	3.9	5.5	-2.3	-1.8	-2.2	-2.1	0.9
Bone: cortical area	1.7	2.5	3.3	-1.8	-1.7	-1.6	-1.7	1.2
Bone: cortical porosity	0.6	0.7	1.1	0.9	0.9	0.6	1.0	-0.6
Bone: cortical porosity	0.3	0.3	0.6	0.6	0.4	0.6	0.8	-0.1
Bone: cortical thickness	1.1	1.8	2.8	-1.6	-1.2	-1.7	-1.4	0.7
Bone: cortical thickness	0.1	0.1	0.3	-0.2	0.2	-0.3	0.2	-0.6
Bone: cortical tissue density	2.8	3.6	5.2	-2.3	-1.8	-2.2	-2.1	0.8
Bone: elastic displacement	1.6	1.8	2.4	1.5	1.3	1.5	1.5	-0.8
Bone: elastic work	1.4	1.8	2.7	1.5	1.2	1.5	1.6	-0.6
Bone: endosteal estimation	0.4	0.9	2.4	-0.2	-1.1	0.7	-0.5	1.6
Bone: endosteal perimeter	0.8	1.7	2.3	-1.3	-1.5	-0.9	-1.5	1.2
Bone: final force	0.5	0.8	1.3	-0.8	-1.1	-0.4	-0.8	1.2
Bone: final moment	0.3	0.6	1.1	-0.6	-0.9	-0.2	-0.6	1.1
Bone: marrow area	0.4	0.8	2.2	-0.2	-1.1	0.6	-0.5	1.5
Bone: maximum diameter	1.0	1.8	2.3	-1.4	-1.5	-1.0	-1.4	1.3
Bone: maximum force	0.3	0.6	1.1	-0.7	-1.0	-0.2	-0.6	1.0
Bone: maximum moment	0.2	0.4	1.0	-0.4	-0.8	0.0	-0.4	1.0
Bone: minimum diameter	3.7	6.8	8.3	-2.8	-2.7	-2.4	-2.9	2.2
Bone: periosteal estimation	0.9	1.8	2.8	-1.3	-1.7	-0.7	-1.3	1.6
Bone: periosteal perimeter	0.7	1.2	1.5	-1.1	-1.2	-0.9	-1.1	1.0
Bone: post-yield work	0.1	0.1	0.3	0.1	0.3	-0.0	0.2	-0.5
Bone: stiffness	2.9	4.7	6.9	-2.0	-2.6	-1.2	-2.0	2.6
Bone: tissue strength	0.5	0.5	1.1	-0.5	-0.8	-0.3	-0.4	1.0
Bone: trabecular number	0.1	0.1	0.4	-0.2	-0.5	0.3	-0.1	0.6
Bone: trabecular spacing	0.7	1.0	1.6	0.9	1.2	0.3	1.0	-1.2
Bone: trabecular thickness	1.7	2.0	2.8	-1.7	-1.4	-1.5	-1.6	0.8
Bone: trabecular tissue density	0.2	0.3	0.4	-0.4	-0.6	-0.5	-0.4	0.6
Breakpoint value in progressive ratio session	0.3	0.3	0.7	0.4	-0.0	0.7	0.3	0.9
Distance traveled before self-admin	1.2	1.2	2.0	-1.4	-1.2	-0.6	-1.4	0.7
Distance traveled after self-admin	0.4	0.5	0.8	-0.8	-0.5	-0.8	-0.9	-0.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.1	0.1	0.2	0.1	-0.3
Delta time in open arm before/after self-admin	0.4	0.4	0.6	0.5	0.8	0.5	0.7	-0.7
Diff in mean of infusions in LGA sessions	2.6	2.9	4.4	2.1	1.5	2.1	2.0	-0.1
Extinction: sum of active levers before priming	3.2	3.2	4.7	2.1	1.6	2.2	1.9	-0.8
Active lever presses in extinction session 6	1.0	1.0	2.2	1.2	0.5	1.5	1.0	0.1
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.1	-0.2
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	0.5	0.4	0.1	0.6	-0.4
Time in closed arm before self-admin	2.4	2.7	3.1	-1.7	-1.8	-1.5	-1.7	1.5
Time in closed arm after self-admin	1.3	1.4	1.9	-1.3	-1.3	-0.9	-1.4	1.0
Time in open arm before self-admin	1.6	1.8	2.7	1.6	1.2	1.3	1.6	-0.7
Time in open arm after self-admin	1.4	1.5	1.9	1.3	1.4	1.1	1.4	-0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.5	-0.6	-0.7	-0.6	0.1
Time to tail flick, vehicle, before self-admin	2.0	2.1	2.8	-1.6	-1.4	-1.5	-1.7	0.8
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.3	-0.1	0.6	0.2	0.3
Time to tail flick, test, before self-admin	0.3	0.3	0.5	-0.7	-0.4	-0.7	-0.5	0.0
Time to tail flick, test, after self-admin	1.5	1.5	2.2	-1.2	-1.4	-0.5	-1.2	1.5
Delta time to tail flick, vehicle, before/after SA	2.3	2.2	2.8	1.7	1.4	1.5	1.6	-1.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	-0.4	-0.5	-0.1	-0.4	0.6
Ambulatory time before self-admin	0.7	0.8	1.3	-1.1	-1.0	-0.4	-1.2	0.5
Ambulatory time after self-admin	0.6	0.7	1.0	-1.0	-0.6	-1.0	-1.0	-0.4
Total heroin consumption	0.1	0.1	0.4	0.3	0.6	0.0	0.4	-0.1
Area under the delay curve	1.0	1.1	1.2	1.1	1.1	1.0	1.1	-1.0
Delay disc. indifference point, 0s delay	0.9	1.0	1.3	1.1	0.9	1.2	1.0	-0.5
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	0.3	-0.0	0.7	0.1	0.1
Delay disc. indifference point, 2s delay	1.0	1.1	1.6	1.1	1.3	0.7	1.0	-1.2
Delay disc. indifference point, 24s delay	0.3	0.2	0.8	0.5	0.1	0.9	0.4	0.1
Delay disc. indifference point, 4s delay	2.2	2.3	3.1	1.5	1.8	1.0	1.6	-1.5
Delay disc. indifference point, 8s delay	0.4	0.4	0.7	0.6	0.7	0.5	0.6	-0.8
Delay discount exponential model param	1.0	1.0	1.2	-1.0	-1.1	-0.8	-1.0	1.1
Delay discount hyperbolic model param	1.0	1.1	1.4	-1.0	-1.2	-0.8	-1.0	1.2
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	-0.7	-0.5	-0.5	-0.7	-0.1
Change in fecal boli incidents, locomotor task	0.9	0.8	1.3	1.1	0.9	0.8	1.0	-0.5
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.0	-0.0
Bouts of movement, locomotor time 1	0.9	1.0	1.5	-0.9	-1.2	-0.5	-1.0	1.1
Total resting periods, locomotor time 1	0.6	0.7	1.2	-0.7	-1.1	-0.4	-0.9	0.9
Rest time, locomotor task time 1	0.1	0.2	0.3	0.4	0.2	0.6	0.5	-0.1
Distance moved, locomotor task time 1	0.3	0.3	0.8	0.5	0.0	0.8	0.3	0.9
Vertical activity count, locomotor time 1	1.3	1.3	3.2	-0.9	-1.2	-0.4	-1.1	1.8
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.6	0.8	0.8	0.4	0.8	-0.7
Bouts of movement, locomotor time 2	0.4	0.5	1.5	0.1	-0.5	0.7	0.0	1.2
Total resting periods, locomotor time 2	0.6	0.7	2.2	-0.1	-0.8	0.8	-0.2	1.5
Rest time, locomotor task time 2	1.0	1.1	3.0	-0.4	-1.3	0.5	-0.6	1.7
Distance moved, locomotor task time 2	0.2	0.3	0.5	-0.0	0.6	-0.7	0.0	-0.7
Vertical activity count, locomotor time 2	0.8	0.9	1.9	-1.0	-0.6	-1.4	-1.0	0.5
Weight adjusted by age	2.1	2.3	3.2	-1.8	-1.4	-1.7	-1.8	0.7
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	1.2	0.9	1.1	0.8	1.0	-1.1
Locomotion in novel chamber	0.7	0.8	1.3	1.1	0.9	0.8	0.9	-0.7
Locomotion in novel chamber post-restriction	0.3	0.3	0.5	0.5	0.6	0.4	0.5	-0.7
Progressive ratio	0.3	0.3	0.5	0.6	0.3	0.7	0.7	-0.0
Food seeking constrained by brief footshock	0.2	0.2	0.9	0.3	0.4	-0.2	0.2	-1.0
Seeking ratio, punishment vs. effort	0.1	0.2	0.6	0.1	0.5	-0.2	-0.0	-0.8
Run reversals in cocaine runway, females	5.2	5.1	7.4	-2.2	-2.7	-1.0	-2.5	2.4
Run reversals in cocaine runway, males	3.8	3.6	6.3	1.6	2.3	0.8	1.9	-2.5
Latency to leave start box in cocaine runway	0.4	0.4	0.7	-0.7	-0.6	-0.5	-0.6	0.8
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.3	0.3	0.3	0.4	0.3
Latency to leave start box in cocaine runway, M	2.3	2.2	3.3	-1.8	-1.2	-1.7	-1.7	0.4
Cd content in liver	5.7	6.3	7.8	-2.6	-2.8	-1.9	-2.8	2.4
Co content in liver	0.3	0.4	0.9	-0.7	-0.2	-0.9	-0.7	-0.3
Cu content in liver	0.1	0.1	0.1	-0.3	0.0	-0.3	-0.2	-0.3
Fe content in liver	0.1	0.2	0.4	-0.2	-0.5	-0.1	-0.2	0.6
K content in liver	0.6	0.6	0.7	0.8	0.8	0.7	0.8	-0.7
Mg content in liver	0.5	0.5	0.6	0.8	0.6	0.8	0.8	-0.4
Mn content in liver	0.2	0.3	0.8	0.3	-0.2	0.6	0.2	0.9
Na content in liver	0.5	0.5	1.1	0.5	0.9	-0.0	0.8	-1.1
Rb content in liver	0.6	0.8	1.6	0.7	0.9	0.6	0.8	-1.3
Se content in liver	0.1	0.1	0.3	0.2	0.3	-0.2	0.2	-0.5
Sr content in liver	0.7	0.7	2.4	0.3	0.9	-0.2	0.2	-1.5
Zn content in liver	0.2	0.2	0.3	-0.4	-0.1	-0.6	-0.4	-0.3