Hub : Genes

Adcy3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000003999 0.39 0.11 1.1e-16 0.12 0.02 0.12 0.06 1.2e-13 3.3e-03 1.9e-13 2.0e-07
2 Brain gene expression ENSRNOG00000003999 0.17 0.13 5.9e-03 0.01 0.02 0.02 0.01 2.2e-02 4.1e-03 2.8e-03 2.5e-02
3 Liver gene expression ENSRNOG00000003999 0.29 0.12 0.0e+00 0.14 0.13 0.13 0.09 2.3e-15 3.8e-14 1.4e-14 3.2e-10
4 PL gene expression ENSRNOG00000003999 0.05 0.05 5.7e-03 0.03 0.02 0.02 0.02 3.4e-03 6.3e-03 1.5e-02 8.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail3.511.515.3-3.8-2.6-3.1-3.9
BMI without tail1.12.43.3-1.8-0.5-1.8-1.6
Body weight2.912.517.9-4.2-1.6-3.6-4.0
Epididymis fat weight20.848.560.8-7.7-5.2-6.8-7.8
Glucose0.30.40.8-0.1-0.9-0.7-0.6
Heart weight4.46.37.8-2.4-2.8-2.2-2.5
Left kidney weight0.20.51.50.41.20.40.5
Right kidney weight0.41.31.8-1.3-0.1-1.3-1.3
Tail length0.31.02.30.71.50.31.1
Length with tail0.20.71.2-0.81.1-0.9-0.5
Length without tail0.20.50.9-0.90.6-0.3-0.8
Liver weight, left1.21.93.2-1.5-0.6-1.8-1.4
Liver weight, right4.67.69.7-3.1-2.1-2.8-2.9
Parametrial fat weight13.025.531.5-5.6-3.3-5.5-5.4
Retroperitoneal fat weight34.0112.6127.5-11.2-9.0-10.8-11.3
Intraocular pressure3.44.85.9-2.2-2.2-1.9-2.4
Extensor digitorum longus weight1.97.79.62.73.12.62.8
Soleus weight3.39.713.63.12.43.23.7
Tibialis anterior weight1.13.94.81.82.01.82.2
Tibia length0.51.52.6-1.4-0.4-1.6-1.2
Number of licking bursts1.61.93.0-1.6-0.6-1.7-1.4
Food consumed during 24 hour testing period0.10.10.20.10.30.10.4
Times rat made contact with spout0.91.01.60.81.01.31.0
Mean time between licks in bursts1.42.02.3-1.4-1.4-1.5-1.4
Mean num. licks in bursts2.53.15.11.80.72.31.8
Std. dev. time between licks in bursts0.30.30.8-0.4-0.9-0.4-0.5
Water consumed over 24 hours0.20.30.50.30.40.70.5
Indifference point 0 sec0.10.20.5-0.1-0.7-0.40.0
Indifference point AUC0.00.00.00.1-0.1-0.1-0.1
Indifference point function ln k1.72.53.21.61.31.61.8
Indifference point function log k1.72.53.21.61.31.61.8
Delay discounting total patch changes 0 sec0.10.10.50.0-0.7-0.20.1
Delay discounting total patch changes 12 sec1.11.52.2-1.2-0.8-1.5-1.2
Delay discounting total patch changes 18 sec0.30.40.7-0.3-0.8-0.7-0.5
Delay discounting total patch changes 24 sec0.50.71.2-0.8-0.7-1.1-0.5
Delay discounting total patch changes 6 sec0.81.31.7-0.9-1.3-1.3-1.0
Delay discounting time to switch 0 sec0.71.11.5-0.9-1.2-0.8-1.2
Delay discounting water rate 0 sec2.54.05.51.91.62.02.4
Delay discounting water rate 12 sec0.00.00.0-0.2-0.1-0.10.1
Delay discounting water rate 18 sec3.04.06.02.11.51.82.4
Delay discounting water rate 24 sec0.00.10.1-0.4-0.2-0.0-0.2
Delay discounting water rate 6 sec1.01.42.31.30.80.91.5
Locomotor activity1.82.94.9-2.00.2-2.2-1.7
Locomotor testing distance1.42.24.8-1.60.0-2.2-1.2
Locomotor testing rearing0.40.61.9-0.51.4-0.6-0.2
Light reinforcement 10.61.11.91.21.10.01.4
Light reinforcement 22.43.24.92.20.71.62.2
Reaction time number correct0.30.40.80.30.90.50.7
Reaction time mean minus median1.21.62.6-1.30.3-1.6-1.4
Reaction time mean minus median AUC1.21.63.1-1.20.4-1.8-1.3
Reaction time num false alarms2.12.94.3-2.0-0.2-2.1-1.8
Reaction time num false alarms AUC1.92.64.1-1.9-0.2-2.0-1.7
Reaction time trials correct on left0.30.40.80.30.90.50.7
Reaction time trials on left0.20.40.80.20.90.40.7
Reaction time mean0.20.30.5-0.3-0.7-0.6-0.6
Reaction time mean AUC0.10.10.2-0.3-0.4-0.4-0.4
Median of all reaction times0.20.20.70.3-0.80.20.0
Reaction time omissions1.01.32.5-1.20.7-1.6-0.9
Reaction time false alarm rate2.23.14.3-1.9-0.9-2.1-1.9
Reaction time premature initiation rate0.00.00.10.1-0.30.30.0
Reaction time premature initiations0.20.20.40.40.10.60.6
Std. dev. reaction times1.21.62.9-1.3-0.0-1.7-1.3
Reaction time trials completed0.20.40.80.20.90.40.7
Reaction time trials AUC0.20.30.80.10.90.30.6
Social response proportion0.10.10.20.2-0.40.4-0.2
Social responses0.20.30.6-0.3-0.2-0.8-0.6
Social time0.00.00.10.2-0.00.3-0.2
Conditioned locomotion2.02.42.81.41.61.41.7
Cocaine response after cond. corrected0.10.10.20.10.4-0.00.3
Cocaine response after cond. not corrected0.60.61.20.61.10.30.9
Cocaine response before conditioning1.72.13.11.31.81.21.5
Saline control response1.72.23.21.60.81.51.8
Condit. Reinf. active minus inactive responses1.21.42.81.31.70.60.9
Condit. Reinf. active-inactive response ratio0.60.72.20.51.50.10.5
Condit. Reinf. active responses0.81.12.31.01.50.40.9
Condit. Reinf. inactive responses0.20.30.70.40.80.20.5
Condit. Reinf. lever presses0.91.21.71.31.30.81.0
Condit. Reinf. lever reinforcers received0.71.02.30.91.50.40.8
Pavlov. Cond. lever latency0.60.81.1-1.1-0.7-1.0-0.8
Pavlov. Cond. magazine entry latency0.00.10.10.3-0.2-0.0-0.3
Pavlov. Cond. change in total contacts0.00.10.10.3-0.00.4-0.2
Pavlov. Cond. index score0.30.40.90.90.30.70.4
Pavlov. Cond. latency score0.40.50.91.00.30.80.4
Pavlov. Cond. lever contacts0.10.10.20.50.40.30.1
Pavlov. Cond. magazine entry number0.20.30.70.20.50.30.9
Pavlov. Cond. intertrial magazine entries1.01.31.5-1.2-1.2-1.1-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.20.50.70.10.50.1
Pavlov. Cond. response bias0.20.30.50.70.50.50.3
Conditioned reinforcement - actives3.83.74.62.11.81.72.0
Conditioned reinforcement - inactives6.57.310.03.22.22.42.9
Conditioned locomotion3.54.26.12.02.02.51.7
Intermittent access intake day 1-15 change3.93.85.72.40.82.02.2
Intermittent access intake escalation2.92.94.52.10.61.71.9
Intermittent access intake escalation 20.70.71.11.0-0.60.90.7
Intermitt. access day 1 inactive lever presses0.20.20.70.10.8-0.30.3
Intermitt. access day 15 inactive lever presses1.41.52.21.21.50.51.5
Intermitt. access escalation Index3.22.96.2-1.5-2.5-1.0-1.5
Intermittent access day 1 total infusions1.31.51.81.31.11.11.3
Intermittent access day 15 total infusions3.13.54.92.21.61.62.0
Intermittent access terminal intake (last 3 days)2.32.53.51.91.41.31.6
Intermittent access total infusions2.12.33.41.51.81.31.3
Intermittent access day 1 locomotion1.91.92.61.51.01.61.4
Intermittent access day 15 total locomotion0.50.50.80.90.40.70.8
Intermittent access total locomotion0.70.81.10.90.91.10.7
Intermittent access standard deviation0.40.50.60.80.70.40.7
Cocaine induced anxiety0.81.01.51.2-0.50.91.1
Post-drug Anxiety0.40.51.3-0.2-1.1-0.7-0.1
Baseline Anxiety1.11.21.8-1.2-0.7-1.4-1.0
Lifetime Intake2.52.83.81.71.91.41.5
Incentive Sensitization - Responses1.51.52.21.50.61.51.0
Incentive Sensitization - Breakpoint1.01.01.61.30.41.30.8
Progressive ratio test 1 active lever presses1.21.23.20.81.80.80.7
Progressive ratio test 1 breakpoint0.90.92.10.81.50.80.7
Progressive ratio test 1 inactive lever presses2.83.05.21.82.31.11.5
Progressive ratio test 2 active lever presses1.61.72.31.51.11.41.2
Progressive ratio test 2 breakpoint1.61.82.41.51.11.51.2
Progressive ratio test 2 inactive lever presses3.33.85.32.31.22.02.1
Total sessions with >9 infusions3.94.37.51.92.71.61.9
Short access day 1 total inactive lever presses1.92.13.01.61.11.31.7
Short access day 10 total inactive lever presses0.40.41.4-0.60.1-1.2-0.3
Short access day 1 total infusions1.71.82.21.51.41.21.2
Short access day 10 total infusions3.23.54.12.02.01.32.0
Short access total infusions2.12.33.21.51.81.31.4
Short access day 1 locomotion2.82.96.61.42.61.31.2
Short access day 10 total locomotion1.41.61.81.11.41.31.3
Short access total locomotion2.22.23.31.31.41.81.4
Compulsive drug intake2.52.58.3-0.9-2.9-0.3-0.8
One hour access (0.3 mA shock)3.23.75.62.40.92.12.0
One hour access (shock baseline)4.24.98.02.32.81.71.9
Number of responses in last shaping day1.31.31.71.30.91.11.3
Context. condit. distance diff. score0.20.20.50.3-0.40.70.3
Locomotion velocity, session 10.20.20.4-0.3-0.4-0.7-0.0
Locomotion distance, session 10.91.12.10.91.40.71.1
Locomotion velocity, session 20.40.51.0-1.0-0.2-0.5-0.8
Locomotion distance, session 20.10.20.6-0.10.80.00.1
Locomotion velocity, session 30.00.00.00.0-0.1-0.0-0.0
Locomotion distance, session 30.00.00.0-0.1-0.0-0.0-0.0
Stereotopy head waving bouts, day 32.42.94.42.10.91.81.8
Stereotopy head waving duration, day 30.50.51.11.00.00.70.8
Locomotion velocity, session 70.10.10.3-0.4-0.20.3-0.5
Locomotion distance, session 70.81.11.9-0.9-1.0-0.6-1.4
Stereotopy head waving bouts, day 70.10.10.2-0.0-0.3-0.10.5
Stereotopy head waving duration, day 70.30.30.80.60.30.30.9
Locomotion velocity, session 80.40.41.00.50.51.00.4
Locomotion distance, session 80.91.32.61.10.01.61.2
Degree of sensitization distance1.11.21.9-1.0-0.9-1.0-1.4
Degree of sensitization stereotypy0.50.50.7-0.8-0.8-0.8-0.3
Condit. Reinf. active minus inactive responses2.42.73.5-1.7-0.9-1.9-1.9
Condit. Reinf. active-inactive response ratio2.12.23.1-1.2-1.3-1.8-1.7
Condit. Reinf. active responses0.30.40.5-0.70.2-0.7-0.7
Condit. Reinf. inactive responses1.41.72.40.91.61.41.2
Incentive salience index mean0.81.01.5-1.10.4-1.2-1.1
Condit. Reinf. lever presses0.70.93.10.11.80.20.6
Time in familiar zone, hab. session 11.51.41.9-1.4-0.9-1.0-1.4
Time in novel zone, hab. session 10.30.20.4-0.5-0.5-0.4-0.6
Total zone transitions, hab. session 10.50.71.10.61.00.70.9
Total locomotion distance, hab. session 11.21.72.21.21.41.01.5
Locomotion velocity, hab. session 12.13.04.31.81.71.42.1
Time in familiar zone, hab. session 20.30.30.9-0.3-1.0-0.2-0.4
Time in novel zone, hab. session 20.30.30.5-0.60.1-0.4-0.7
Total zone transitions, hab. session 20.00.10.1-0.10.30.20.3
Total locomotion distance, hab. session 20.00.10.1-0.10.3-0.00.3
Locomotion velocity, hab. session 20.10.20.4-0.00.6-0.00.5
Novel to familiar place preference ratio0.00.00.00.1-0.00.00.2
Novelty place preference0.00.00.1-0.2-0.2-0.3-0.0
Time in novel zone, NPP test0.10.10.1-0.4-0.2-0.2-0.3
Total zone transitions, NPP test0.71.12.70.51.60.60.9
Total locomotion distance, NPP test1.52.03.61.11.91.21.4
Locomotion velocity, NPP test2.23.14.91.52.21.21.9
Pavlov. Cond. lever latency0.30.30.9-0.0-1.0-0.3-0.5
Pavlov. Cond. magazine entry latency0.20.20.6-0.80.2-0.4-0.4
Pavlov. Cond. change in total contacts0.10.10.2-0.2-0.20.40.1
Pavlov. Cond. index score0.10.10.3-0.60.30.10.0
Pavlov. Cond. latency score0.10.10.3-0.60.20.10.0
Pavlov. Cond. lever contacts0.20.20.5-0.00.70.30.5
Pavlov. Cond. magazine entry number0.10.10.30.4-0.6-0.0-0.2
Pavlov. Cond. intertrial magazine entries1.01.21.51.20.91.21.0
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.10.60.50.4
Pavlov. Cond. response bias0.60.71.20.41.10.80.9
Bone: apparent density3.35.47.52.22.02.32.7
Bone surface0.81.42.30.90.81.41.5
Bone volume1.93.34.61.61.42.02.1
Bone: connectivity density1.82.94.41.61.31.72.1
Bone: cortical apparent density0.10.20.40.6-0.40.30.4
Bone: cortical area0.10.20.3-0.30.5-0.5-0.1
Bone: cortical porosity2.62.84.71.42.21.51.5
Bone: cortical porosity1.92.13.71.11.91.41.2
Bone: cortical thickness0.10.20.4-0.50.0-0.7-0.4
Bone: cortical thickness0.70.91.40.91.20.90.7
Bone: cortical tissue density0.10.10.20.5-0.40.20.3
Bone: elastic displacement2.02.33.01.71.41.21.7
Bone: elastic work1.01.42.11.40.61.11.4
Bone: endosteal estimation0.20.30.60.50.30.60.8
Bone: endosteal perimeter0.00.10.1-0.20.3-0.30.0
Bone: final force0.10.20.3-0.50.1-0.5-0.2
Bone: final moment0.10.10.2-0.40.1-0.4-0.1
Bone: marrow area0.20.30.60.50.40.60.7
Bone: maximum diameter0.10.10.20.30.5-0.00.5
Bone: maximum force0.10.10.2-0.40.3-0.4-0.2
Bone: maximum moment0.00.00.1-0.30.3-0.2-0.0
Bone: minimum diameter0.81.42.2-1.5-0.5-1.4-1.2
Bone: periosteal estimation0.10.30.60.40.70.40.6
Bone: periosteal perimeter0.10.10.2-0.10.3-0.40.1
Bone: post-yield work1.11.52.41.01.61.20.9
Bone: stiffness0.10.20.4-0.6-0.4-0.4-0.2
Bone: tissue strength0.50.51.3-0.5-1.1-0.6-0.5
Bone: trabecular number3.25.07.12.11.92.22.7
Bone: trabecular spacing0.60.80.9-0.7-0.9-0.9-1.0
Bone: trabecular thickness0.20.30.90.20.90.30.3
Bone: trabecular tissue density0.00.10.20.10.50.1-0.1
Breakpoint value in progressive ratio session1.61.83.21.30.61.81.3
Distance traveled before self-admin0.10.10.30.20.60.30.1
Distance traveled after self-admin0.10.10.2-0.1-0.50.30.2
Delta time in closed arm before/after self-admin0.20.20.6-0.4-0.8-0.3-0.3
Delta time in open arm before/after self-admin0.70.71.1-0.51.1-1.0-0.6
Diff in mean of infusions in LGA sessions0.20.30.6-0.80.3-0.5-0.4
Extinction: sum of active levers before priming0.10.10.40.10.60.40.1
Active lever presses in extinction session 61.41.45.20.32.3-0.20.4
Delta distance traveled before/after self-admin1.11.22.3-1.0-1.5-1.0-0.7
Delta ambulatory time before/after self-admin0.40.41.5-0.2-1.20.00.0
Time in closed arm before self-admin0.10.20.60.10.8-0.10.2
Time in closed arm after self-admin0.50.60.9-0.90.4-0.9-0.6
Time in open arm before self-admin0.30.30.8-0.4-0.90.1-0.4
Time in open arm after self-admin0.00.00.10.30.10.20.1
Sum of active levers in priming session hrs 5-60.10.10.10.1-0.20.20.4
Time to tail flick, vehicle, before self-admin1.71.72.6-1.60.5-1.6-1.2
Time to tail flick, vehicle, after self-admin6.26.710.0-2.7-1.6-2.6-3.2
Time to tail flick, test, before self-admin1.61.62.10.91.41.41.2
Time to tail flick, test, after self-admin1.01.01.41.01.01.20.8
Delta time to tail flick, vehicle, before/after SA1.31.32.4-0.7-1.5-0.8-1.2
Delta time to tail flick, test, before/after SA1.71.52.51.60.11.51.2
Ambulatory time before self-admin0.20.20.60.00.80.20.0
Ambulatory time after self-admin0.10.10.20.2-0.20.10.4
Total heroin consumption2.73.35.42.00.22.31.9
Area under the delay curve0.10.10.4-0.2-0.60.1-0.3
Delay disc. indifference point, 0s delay0.50.62.1-0.2-1.4-0.4-0.2
Delay disc. indifference point, 16s delay0.00.00.1-0.1-0.30.10.0
Delay disc. indifference point, 2s delay0.50.51.7-0.3-1.30.3-0.4
Delay disc. indifference point, 24s delay2.12.13.51.11.91.31.3
Delay disc. indifference point, 4s delay0.40.41.4-0.1-1.20.4-0.1
Delay disc. indifference point, 8s delay0.00.00.1-0.1-0.30.1-0.0
Delay discount exponential model param0.10.10.20.10.4-0.40.1
Delay discount hyperbolic model param0.10.10.40.10.6-0.40.1
Fecal boli incidents, locomotor time 13.53.84.52.11.42.02.1
Change in fecal boli incidents, locomotor task3.33.26.1-1.6-2.5-1.2-1.6
Time >=10cm from walls, locomotor time 10.70.71.10.81.00.80.6
Bouts of movement, locomotor time 10.30.30.80.4-0.00.30.9
Total resting periods, locomotor time 10.40.51.20.6-0.00.61.1
Rest time, locomotor task time 10.20.30.50.6-0.30.30.7
Distance moved, locomotor task time 10.70.81.5-1.10.0-0.7-1.2
Vertical activity count, locomotor time 10.20.20.3-0.5-0.50.1-0.6
Time >=10cm from walls, locomotor time 21.81.92.71.60.91.61.1
Bouts of movement, locomotor time 20.10.10.5-0.2-0.70.10.1
Total resting periods, locomotor time 20.20.20.7-0.2-0.90.10.2
Rest time, locomotor task time 20.10.10.10.0-0.4-0.10.3
Distance moved, locomotor task time 20.00.00.00.20.10.2-0.2
Vertical activity count, locomotor time 20.10.10.20.4-0.30.40.2
Weight adjusted by age1.21.31.9-1.4-0.2-1.3-1.3
Seeking ratio, delayed vs. immediate footshock0.30.30.6-0.6-0.0-0.6-0.8
Locomotion in novel chamber1.31.62.2-1.40.4-1.4-1.5
Locomotion in novel chamber post-restriction1.31.64.4-0.9-2.1-0.3-1.0
Progressive ratio0.30.41.0-0.51.0-0.1-0.5
Food seeking constrained by brief footshock9.211.219.92.84.52.83.0
Seeking ratio, punishment vs. effort1.72.02.91.60.81.41.7
Run reversals in cocaine runway, females0.70.71.21.0-0.00.71.1
Run reversals in cocaine runway, males1.51.52.31.21.20.71.5
Latency to leave start box in cocaine runway0.10.10.30.20.20.60.1
Latency to leave start box in cocaine runway, F0.10.10.2-0.40.1-0.0-0.4
Latency to leave start box in cocaine runway, M1.31.21.61.30.91.21.0
Cd content in liver0.00.00.0-0.2-0.10.2-0.2
Co content in liver2.73.24.81.52.21.71.7
Cu content in liver0.70.91.4-1.00.7-0.8-1.2
Fe content in liver0.40.40.80.80.20.90.6
K content in liver2.32.33.0-1.6-0.7-1.7-1.7
Mg content in liver1.41.41.7-1.1-1.3-1.1-1.3
Mn content in liver0.30.30.9-0.2-0.90.2-0.5
Na content in liver2.83.04.62.11.01.52.1
Rb content in liver0.40.51.0-0.7-0.2-1.0-0.7
Se content in liver0.81.01.5-0.9-1.0-0.7-1.2
Sr content in liver0.20.20.6-0.2-0.80.2-0.2
Zn content in liver4.14.66.6-2.5-0.2-2.6-2.3