Hub : Genes

Dnajc27

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000003988 0.59 0 0.0e+00 0.32 0.34 0.35 0.34 1.1e-35 6.5e-39 1.1e-39 4.5e-39
2 Brain gene expression ENSRNOG00000003988 0.03 0.03 1.2e-03 0.03 0.03 0.02 0.02 1.1e-03 1.0e-03 3.2e-03 3.8e-03
3 NAcc gene expression ENSRNOG00000003988 0.08 0.05 5.0e-09 0.08 0.11 0.1 0.09 8.7e-07 2.7e-08 1.5e-07 1.9e-07
4 PL gene expression ENSRNOG00000003988 0.18 0.12 2.5e-03 0.03 0.04 0.04 0.03 1.6e-03 6.1e-04 8.9e-04 2.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail3.611.712.63.53.43.33.4
BMI without tail1.02.23.31.21.41.41.8
Body weight3.213.615.83.63.73.54.0
Epididymis fat weight22.552.457.67.67.47.26.7
Glucose0.20.30.60.70.60.60.3
Heart weight4.26.17.42.62.72.71.6
Left kidney weight0.10.40.7-0.5-0.7-0.80.4
Right kidney weight0.61.83.21.21.21.01.8
Tail length0.30.81.5-1.2-0.9-0.8-0.7
Length with tail0.10.30.50.20.50.50.7
Length without tail0.20.40.70.70.60.40.8
Liver weight, left1.11.81.91.31.41.41.4
Liver weight, right4.67.78.92.82.93.02.3
Parametrial fat weight14.027.528.25.35.35.25.2
Retroperitoneal fat weight36.3120.2132.811.411.511.39.5
Intraocular pressure3.44.86.22.52.42.31.4
Extensor digitorum longus weight1.87.38.7-2.9-2.9-2.9-1.9
Soleus weight3.811.012.9-3.6-3.4-3.2-3.1
Tibialis anterior weight1.13.94.9-2.2-2.0-1.9-1.7
Tibia length0.61.82.41.21.51.51.0
Number of licking bursts1.72.02.21.21.41.41.5
Food consumed during 24 hour testing period0.10.10.3-0.5-0.2-0.1-0.5
Times rat made contact with spout1.01.11.3-1.0-1.0-1.0-1.1
Mean time between licks in bursts1.31.92.31.41.41.51.1
Mean num. licks in bursts2.83.44.7-1.6-1.8-1.8-2.2
Std. dev. time between licks in bursts0.20.20.40.50.50.6-0.1
Water consumed over 24 hours0.30.30.6-0.5-0.5-0.4-0.8
Indifference point 0 sec0.10.20.30.30.40.5-0.4
Indifference point AUC0.00.00.1-0.0-0.1-0.10.3
Indifference point function ln k1.82.52.8-1.6-1.7-1.7-1.4
Indifference point function log k1.82.52.8-1.6-1.7-1.7-1.4
Delay discounting total patch changes 0 sec0.10.10.30.10.30.4-0.5
Delay discounting total patch changes 12 sec1.21.62.01.11.31.31.4
Delay discounting total patch changes 18 sec0.20.30.50.50.70.7-0.0
Delay discounting total patch changes 24 sec0.40.51.00.50.81.00.4
Delay discounting total patch changes 6 sec0.91.32.01.21.21.40.6
Delay discounting time to switch 0 sec0.81.21.71.31.21.10.9
Delay discounting water rate 0 sec3.15.05.6-2.4-2.2-2.1-2.2
Delay discounting water rate 12 sec0.00.00.1-0.00.00.1-0.3
Delay discounting water rate 18 sec3.54.75.8-2.3-2.0-1.8-2.4
Delay discounting water rate 24 sec0.00.00.10.30.20.20.0
Delay discounting water rate 6 sec1.11.62.3-1.4-1.1-1.0-1.5
Locomotor activity2.23.46.21.51.71.62.5
Locomotor testing distance1.52.55.01.11.41.42.2
Locomotor testing rearing0.30.52.1-0.2-0.1-0.21.4
Light reinforcement 10.51.02.1-1.5-0.9-0.9-0.4
Light reinforcement 22.53.33.9-2.0-1.7-1.7-1.9
Reaction time number correct0.40.50.7-0.9-0.7-0.6-0.7
Reaction time mean minus median1.62.14.91.11.21.02.2
Reaction time mean minus median AUC1.41.73.70.91.21.01.9
Reaction time num false alarms2.12.93.81.41.71.71.9
Reaction time num false alarms AUC1.82.53.11.31.71.71.8
Reaction time trials correct on left0.40.50.7-0.9-0.7-0.6-0.7
Reaction time trials on left0.30.40.6-0.8-0.6-0.6-0.5
Reaction time mean0.30.40.40.60.60.50.6
Reaction time mean AUC0.10.20.30.40.40.30.6
Median of all reaction times0.00.00.10.10.10.1-0.3
Reaction time omissions0.81.02.20.40.90.91.5
Reaction time false alarm rate2.43.43.71.71.91.91.8
Reaction time premature initiation rate0.10.10.40.00.00.1-0.7
Reaction time premature initiations0.30.41.2-0.5-0.4-0.3-1.1
Std. dev. reaction times1.41.93.51.01.31.21.9
Reaction time trials completed0.30.40.6-0.8-0.6-0.6-0.5
Reaction time trials AUC0.20.30.5-0.7-0.6-0.6-0.4
Social response proportion0.10.10.30.50.1-0.00.1
Social responses0.40.50.60.70.60.60.8
Social time0.00.00.00.1-0.0-0.10.2
Conditioned locomotion2.22.73.7-1.8-1.8-1.9-0.6
Cocaine response after cond. corrected0.10.10.1-0.3-0.3-0.30.1
Cocaine response after cond. not corrected0.50.60.9-1.0-0.8-0.8-0.3
Cocaine response before conditioning1.51.92.5-1.6-1.4-1.5-0.9
Saline control response1.72.32.6-1.5-1.6-1.6-1.3
Condit. Reinf. active minus inactive responses0.81.01.4-1.2-1.1-1.2-0.4
Condit. Reinf. active-inactive response ratio0.30.40.6-0.8-0.6-0.70.2
Condit. Reinf. active responses0.50.81.3-1.1-0.9-0.9-0.3
Condit. Reinf. inactive responses0.20.20.4-0.7-0.5-0.4-0.2
Condit. Reinf. lever presses0.71.01.3-1.1-1.1-1.1-0.6
Condit. Reinf. lever reinforcers received0.40.61.1-1.0-0.8-0.9-0.2
Pavlov. Cond. lever latency0.60.81.10.81.01.00.7
Pavlov. Cond. magazine entry latency0.00.00.00.10.00.0-0.1
Pavlov. Cond. change in total contacts0.00.00.00.1-0.2-0.2-0.1
Pavlov. Cond. index score0.30.40.5-0.4-0.7-0.7-0.6
Pavlov. Cond. latency score0.30.40.5-0.5-0.7-0.7-0.6
Pavlov. Cond. lever contacts0.10.10.2-0.2-0.4-0.40.0
Pavlov. Cond. magazine entry number0.20.30.5-0.7-0.5-0.4-0.5
Pavlov. Cond. intertrial magazine entries1.21.62.41.31.51.60.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.2-0.4-0.4-0.5
Pavlov. Cond. response bias0.20.30.4-0.4-0.6-0.6-0.2
Conditioned reinforcement - actives3.93.84.2-2.0-2.0-2.0-1.7
Conditioned reinforcement - inactives6.47.38.5-2.8-2.9-2.9-2.1
Conditioned locomotion3.84.55.6-1.8-2.3-2.4-2.0
Intermittent access intake day 1-15 change4.94.87.6-2.0-2.0-1.9-2.8
Intermittent access intake escalation3.73.66.4-1.7-1.7-1.6-2.5
Intermittent access intake escalation 21.01.03.5-0.4-0.5-0.4-1.9
Intermitt. access day 1 inactive lever presses0.20.20.2-0.5-0.5-0.40.3
Intermitt. access day 15 inactive lever presses1.01.12.0-1.4-1.1-1.1-0.0
Intermitt. access escalation Index2.82.53.41.91.81.70.7
Intermittent access day 1 total infusions1.51.72.5-1.4-1.5-1.6-0.2
Intermittent access day 15 total infusions3.53.94.6-2.1-2.1-2.2-1.5
Intermittent access terminal intake (last 3 days)2.73.03.7-1.7-1.9-1.9-1.3
Intermittent access total infusions2.32.53.9-1.6-1.8-2.0-0.4
Intermittent access day 1 locomotion2.32.32.9-1.5-1.7-1.7-1.2
Intermittent access day 15 total locomotion0.60.60.7-0.8-0.8-0.8-0.8
Intermittent access total locomotion0.91.01.3-0.9-1.1-1.1-0.8
Intermittent access standard deviation0.60.70.8-0.9-0.9-0.9-0.6
Cocaine induced anxiety0.70.82.2-0.7-0.6-0.5-1.5
Post-drug Anxiety0.30.30.60.30.60.8-0.5
Baseline Anxiety0.90.91.30.81.11.20.8
Lifetime Intake2.73.04.6-1.7-2.0-2.1-0.6
Incentive Sensitization - Responses1.71.72.0-1.1-1.3-1.4-1.4
Incentive Sensitization - Breakpoint1.21.31.7-0.8-1.1-1.2-1.3
Progressive ratio test 1 active lever presses1.21.21.8-1.2-1.3-1.30.3
Progressive ratio test 1 breakpoint0.90.91.4-1.0-1.2-1.20.1
Progressive ratio test 1 inactive lever presses2.62.74.0-1.8-1.9-2.0-0.2
Progressive ratio test 2 active lever presses2.02.12.7-1.3-1.6-1.6-1.2
Progressive ratio test 2 breakpoint2.02.22.9-1.3-1.7-1.7-1.2
Progressive ratio test 2 inactive lever presses3.64.24.7-2.0-2.2-2.1-1.9
Total sessions with >9 infusions4.34.76.4-2.3-2.5-2.5-1.0
Short access day 1 total inactive lever presses2.12.42.9-1.6-1.7-1.6-1.1
Short access day 10 total inactive lever presses0.40.51.30.30.50.51.1
Short access day 1 total infusions1.81.93.2-1.3-1.6-1.8-0.3
Short access day 10 total infusions3.23.55.1-2.1-2.1-2.3-0.6
Short access total infusions2.12.43.7-1.5-1.8-1.9-0.3
Short access day 1 locomotion2.52.64.1-1.6-1.9-2.0-0.5
Short access day 10 total locomotion1.51.62.0-1.3-1.4-1.4-1.0
Short access total locomotion2.52.53.1-1.5-1.8-1.7-1.3
Compulsive drug intake1.91.92.61.61.51.6-0.4
One hour access (0.3 mA shock)3.84.46.4-1.8-2.0-2.0-2.5
One hour access (shock baseline)4.14.76.7-2.2-2.4-2.6-1.2
Number of responses in last shaping day1.51.52.3-1.2-1.4-1.5-0.6
Context. condit. distance diff. score0.10.10.2-0.2-0.4-0.4-0.4
Locomotion velocity, session 10.20.20.40.20.50.60.1
Locomotion distance, session 10.81.01.5-1.2-1.0-0.9-0.8
Locomotion velocity, session 20.50.61.10.70.70.61.1
Locomotion distance, session 20.00.00.1-0.3-0.00.0-0.2
Locomotion velocity, session 30.00.00.00.1-0.0-0.00.2
Locomotion distance, session 30.00.00.00.00.00.1-0.1
Stereotopy head waving bouts, day 32.32.82.9-1.6-1.7-1.7-1.7
Stereotopy head waving duration, day 30.30.40.4-0.5-0.6-0.6-0.7
Locomotion velocity, session 70.10.10.20.40.10.10.2
Locomotion distance, session 70.91.11.71.31.11.00.8
Stereotopy head waving bouts, day 70.00.00.1-0.3-0.1-0.1-0.1
Stereotopy head waving duration, day 70.30.40.5-0.7-0.7-0.6-0.3
Locomotion velocity, session 80.30.40.6-0.5-0.7-0.8-0.5
Locomotion distance, session 81.01.52.4-1.0-1.2-1.1-1.6
Degree of sensitization distance1.41.41.71.31.21.11.2
Degree of sensitization stereotypy0.30.30.30.40.50.60.6
Condit. Reinf. active minus inactive responses2.73.13.51.71.91.81.6
Condit. Reinf. active-inactive response ratio2.62.83.31.71.81.81.3
Condit. Reinf. active responses0.30.30.50.50.60.60.7
Condit. Reinf. inactive responses1.61.92.2-1.5-1.5-1.4-1.1
Incentive salience index mean0.81.01.80.70.90.91.3
Condit. Reinf. lever presses0.40.61.1-1.0-0.7-0.80.2
Time in familiar zone, hab. session 11.81.72.01.31.31.21.4
Time in novel zone, hab. session 10.30.30.50.70.60.50.2
Total zone transitions, hab. session 10.50.81.1-1.0-0.9-0.7-0.9
Total locomotion distance, hab. session 11.21.82.4-1.6-1.3-1.2-1.2
Locomotion velocity, hab. session 12.43.44.5-2.1-1.8-1.7-1.7
Time in familiar zone, hab. session 20.20.20.40.70.50.50.1
Time in novel zone, hab. session 20.30.30.50.60.50.40.7
Total zone transitions, hab. session 20.20.20.6-0.3-0.20.0-0.8
Total locomotion distance, hab. session 20.10.20.5-0.3-0.10.1-0.7
Locomotion velocity, hab. session 20.20.20.5-0.6-0.2-0.0-0.7
Novel to familiar place preference ratio0.10.10.4-0.30.00.2-0.7
Novelty place preference0.10.10.2-0.00.30.4-0.3
Time in novel zone, NPP test0.10.10.30.20.40.5-0.2
Total zone transitions, NPP test0.60.91.3-1.1-1.0-1.0-0.3
Total locomotion distance, NPP test1.41.92.6-1.6-1.4-1.4-0.9
Locomotion velocity, NPP test2.23.14.5-2.1-1.8-1.7-1.2
Pavlov. Cond. lever latency0.30.40.50.70.60.7-0.2
Pavlov. Cond. magazine entry latency0.10.10.30.10.20.20.5
Pavlov. Cond. change in total contacts0.00.00.1-0.2-0.3-0.2-0.0
Pavlov. Cond. index score0.00.10.1-0.2-0.2-0.20.3
Pavlov. Cond. latency score0.00.00.0-0.2-0.2-0.10.2
Pavlov. Cond. lever contacts0.30.30.5-0.7-0.6-0.60.1
Pavlov. Cond. magazine entry number0.10.10.20.40.30.20.0
Pavlov. Cond. intertrial magazine entries0.81.01.6-0.9-1.1-1.3-0.6
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.6-0.6-0.60.0
Pavlov. Cond. response bias0.70.91.2-1.1-1.1-1.1-0.3
Bone: apparent density3.66.06.8-2.5-2.6-2.5-2.1
Bone surface0.91.61.7-1.3-1.3-1.2-1.3
Bone volume2.23.84.2-1.9-2.0-2.0-1.8
Bone: connectivity density2.03.23.6-1.8-1.9-1.9-1.5
Bone: cortical apparent density0.10.10.4-0.2-0.2-0.2-0.6
Bone: cortical area0.00.00.1-0.10.20.20.3
Bone: cortical porosity2.22.43.4-1.6-1.7-1.8-0.7
Bone: cortical porosity1.61.72.6-1.3-1.5-1.6-0.5
Bone: cortical thickness0.10.20.30.30.50.60.2
Bone: cortical thickness0.70.80.8-0.9-0.9-0.9-0.9
Bone: cortical tissue density0.10.10.3-0.1-0.1-0.1-0.5
Bone: elastic displacement2.12.32.6-1.6-1.6-1.5-1.4
Bone: elastic work1.31.72.6-1.2-1.2-1.1-1.6
Bone: endosteal estimation0.20.40.5-0.7-0.6-0.6-0.6
Bone: endosteal perimeter0.00.00.1-0.10.10.10.3
Bone: final force0.10.10.30.30.30.30.5
Bone: final moment0.00.10.10.20.20.20.3
Bone: marrow area0.20.40.5-0.7-0.6-0.6-0.6
Bone: maximum diameter0.10.10.3-0.5-0.2-0.2-0.3
Bone: maximum force0.00.10.20.20.20.20.4
Bone: maximum moment0.00.00.00.00.10.10.2
Bone: minimum diameter0.91.62.11.11.31.21.4
Bone: periosteal estimation0.20.30.5-0.7-0.6-0.5-0.4
Bone: periosteal perimeter0.00.00.0-0.20.10.10.2
Bone: post-yield work0.91.21.7-1.1-1.2-1.3-0.3
Bone: stiffness0.10.20.20.30.40.40.4
Bone: tissue strength0.40.40.70.90.60.70.2
Bone: trabecular number3.55.56.3-2.4-2.5-2.5-1.9
Bone: trabecular spacing0.50.71.00.80.91.00.5
Bone: trabecular thickness0.10.20.3-0.4-0.4-0.60.2
Bone: trabecular tissue density0.00.00.0-0.1-0.0-0.10.2
Breakpoint value in progressive ratio session1.21.31.5-1.0-1.2-1.2-1.2
Distance traveled before self-admin0.00.00.1-0.2-0.2-0.20.1
Distance traveled after self-admin0.10.10.20.10.10.1-0.5
Delta time in closed arm before/after self-admin0.30.30.40.60.60.60.5
Delta time in open arm before/after self-admin0.10.10.5-0.10.00.00.7
Diff in mean of infusions in LGA sessions0.40.41.40.30.30.21.2
Extinction: sum of active levers before priming0.20.20.6-0.1-0.2-0.30.8
Active lever presses in extinction session 60.90.81.1-0.9-0.8-0.91.0
Delta distance traveled before/after self-admin0.91.01.31.11.11.20.4
Delta ambulatory time before/after self-admin0.10.20.30.40.20.3-0.6
Time in closed arm before self-admin0.10.10.2-0.4-0.1-0.1-0.3
Time in closed arm after self-admin0.70.71.20.50.90.91.1
Time in open arm before self-admin0.10.10.30.60.20.20.0
Time in open arm after self-admin0.20.20.3-0.3-0.4-0.4-0.5
Sum of active levers in priming session hrs 5-60.10.10.2-0.3-0.1-0.0-0.4
Time to tail flick, vehicle, before self-admin1.51.53.30.81.00.91.8
Time to tail flick, vehicle, after self-admin8.69.110.03.23.13.02.8
Time to tail flick, test, before self-admin1.51.51.7-1.3-1.3-1.3-0.9
Time to tail flick, test, after self-admin0.80.81.1-0.8-1.0-1.1-0.5
Delta time to tail flick, vehicle, before/after SA1.81.72.31.51.41.50.6
Delta time to tail flick, test, before/after SA1.21.11.5-0.8-1.2-1.2-1.0
Ambulatory time before self-admin0.10.10.1-0.3-0.1-0.10.4
Ambulatory time after self-admin0.10.10.3-0.2-0.1-0.0-0.5
Total heroin consumption3.13.75.7-1.6-1.9-1.8-2.4
Area under the delay curve0.00.00.10.40.10.20.0
Delay disc. indifference point, 0s delay0.20.30.40.50.50.6-0.4
Delay disc. indifference point, 16s delay0.00.00.10.10.10.1-0.2
Delay disc. indifference point, 2s delay0.10.20.50.70.20.2-0.4
Delay disc. indifference point, 24s delay2.52.43.0-1.6-1.7-1.7-1.0
Delay disc. indifference point, 4s delay0.10.10.20.50.30.3-0.3
Delay disc. indifference point, 8s delay0.00.00.00.1-0.0-0.00.1
Delay discount exponential model param0.00.00.0-0.20.10.00.1
Delay discount hyperbolic model param0.00.00.1-0.30.0-0.00.1
Fecal boli incidents, locomotor time 13.94.34.7-2.0-2.2-2.1-1.9
Change in fecal boli incidents, locomotor task3.63.44.22.02.11.91.3
Time >=10cm from walls, locomotor time 10.30.30.4-0.7-0.5-0.6-0.1
Bouts of movement, locomotor time 10.60.60.9-0.9-0.7-0.5-1.0
Total resting periods, locomotor time 10.80.91.4-1.1-0.8-0.6-1.2
Rest time, locomotor task time 10.30.30.7-0.5-0.5-0.4-0.8
Distance moved, locomotor task time 11.01.11.71.00.90.81.3
Vertical activity count, locomotor time 10.20.20.30.60.50.4-0.0
Time >=10cm from walls, locomotor time 21.01.11.6-0.9-1.1-1.2-0.8
Bouts of movement, locomotor time 20.20.20.70.00.10.3-0.8
Total resting periods, locomotor time 20.20.20.70.00.10.3-0.8
Rest time, locomotor task time 20.00.00.1-0.2-0.2-0.1-0.3
Distance moved, locomotor task time 20.00.00.10.20.0-0.10.1
Vertical activity count, locomotor time 20.10.10.20.0-0.3-0.4-0.1
Weight adjusted by age1.71.93.71.11.31.01.9
Seeking ratio, delayed vs. immediate footshock0.40.51.10.60.50.41.0
Locomotion in novel chamber1.51.83.21.21.21.11.8
Locomotion in novel chamber post-restriction1.01.21.81.21.31.3-0.1
Progressive ratio0.20.20.70.2-0.0-0.20.8
Food seeking constrained by brief footshock8.910.815.4-3.6-3.7-3.9-1.1
Seeking ratio, punishment vs. effort1.82.22.5-1.6-1.5-1.5-1.4
Run reversals in cocaine runway, females0.80.81.1-0.9-0.9-0.8-1.1
Run reversals in cocaine runway, males1.61.62.2-1.5-1.3-1.2-1.0
Latency to leave start box in cocaine runway0.00.00.10.0-0.2-0.30.0
Latency to leave start box in cocaine runway, F0.20.20.50.40.30.20.7
Latency to leave start box in cocaine runway, M1.11.11.5-1.0-1.2-1.2-0.7
Cd content in liver0.10.10.3-0.00.20.3-0.6
Co content in liver2.93.44.6-2.0-2.0-2.1-0.9
Cu content in liver0.91.13.20.70.70.41.8
Fe content in liver0.40.50.7-0.6-0.7-0.6-0.9
K content in liver2.52.52.61.51.61.61.6
Mg content in liver1.41.51.81.31.31.30.9
Mn content in liver0.10.10.30.60.20.3-0.2
Na content in liver3.03.23.6-1.8-1.9-1.8-1.6
Rb content in liver0.50.60.80.60.90.90.8
Se content in liver0.81.01.61.31.01.00.6
Sr content in liver0.10.10.10.40.10.1-0.2
Zn content in liver4.65.08.91.82.11.93.0