| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000003846 | 0.044 | 0.029 | 3.1e-05 | 0.034 | 0.034 | 0.021 | 0.032 | 1.1e-04 | 0.00011 | 1.8e-03 | 1.5e-04 |
| 2 | Brain | gene expression | ENSRNOG00000003846 | 0.026 | 0.021 | 7.8e-03 | 0.000 | 0.014 | 0.008 | 0.005 | 3.1e-01 | 0.01600 | 4.9e-02 | 1.1e-01 |
| 3 | Eye | intron excision ratio | chr10:60430987:60434857 | 0.243 | 0.152 | 3.1e-03 | 0.340 | 0.182 | 0.268 | 0.304 | 3.4e-06 | 0.00095 | 5.1e-05 | 1.4e-05 |
| 4 | Eye | intron excision ratio | chr10:60434887:60440812 | 0.274 | 0.163 | 1.8e-03 | 0.357 | 0.225 | 0.303 | 0.353 | 1.8e-06 | 0.00023 | 1.4e-05 | 2.1e-06 |
| 5 | Liver | gene expression | ENSRNOG00000003846 | 0.029 | 0.022 | 8.7e-04 | 0.021 | 0.014 | 0.008 | 0.014 | 1.7e-03 | 0.01000 | 4.1e-02 | 1.1e-02 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 |
|---|---|---|---|---|---|---|---|---|
| Parametrial fat weight | 9.4 | 18.3 | 22.1 | -4.4 | -4.7 | 3.9 | -3.9 | -4.4 |
| Intermitt. access escalation Index | 6.8 | 6.0 | 7.6 | -2.4 | -1.8 | 2.8 | -2.8 | -2.4 |
| Locomotion in novel chamber | 6.1 | 7.5 | 8.5 | 2.8 | 2.3 | -2.9 | 2.9 | 2.8 |
| Time in open arm before self-admin | 5.1 | 5.5 | 7.7 | 2.0 | 2.8 | -2.4 | 2.4 | 2.0 |
| Social response proportion | 5.0 | 5.4 | 6.3 | -2.3 | -2.0 | 2.5 | -2.5 | -2.3 |
| Time to tail flick, vehicle, before self-admin | 5.0 | 5.0 | 7.5 | -2.2 | -2.7 | 2.0 | -2.0 | -2.2 |
| Soleus weight | 4.5 | 13.1 | 15.1 | -3.5 | -3.9 | 3.6 | -3.6 | -3.4 |
| Total heroin consumption | 4.5 | 5.4 | 6.0 | -2.4 | -2.5 | 2.2 | -2.2 | -2.4 |
| Locomotion velocity, session 1 | 4.4 | 4.7 | 5.1 | -2.1 | -2.3 | 2.2 | -2.2 | -2.1 |
| Intermittent access standard deviation | 4.2 | 4.5 | 5.3 | 2.2 | 1.4 | -2.3 | 2.3 | 2.3 |
| Epididymis fat weight | 3.6 | 8.5 | 10.7 | -2.8 | -3.3 | 2.9 | -2.9 | -2.7 |
| Tibialis anterior weight | 3.5 | 12.0 | 26.4 | -3.1 | -5.1 | 2.7 | -2.7 | -3.1 |
| Social time | 3.2 | 4.2 | 5.1 | -2.0 | -2.3 | 2.1 | -2.1 | -1.9 |
| Intermittent access intake escalation 2 | 3.1 | 3.0 | 3.6 | 1.9 | 1.6 | -1.7 | 1.7 | 1.9 |
| Bone: connectivity density | 3.0 | 4.7 | 8.7 | -1.9 | -3.0 | 2.0 | -2.0 | -1.9 |
| Time in closed arm before self-admin | 2.9 | 3.3 | 3.7 | -1.7 | -1.9 | 1.9 | -1.9 | -1.7 |
| Glucose | 2.8 | 4.2 | 5.9 | 1.8 | 2.4 | -2.1 | 2.1 | 1.8 |
| Sum of active levers in priming session hrs 5-6 | 2.8 | 2.7 | 2.9 | -1.7 | -1.7 | 1.6 | -1.6 | -1.7 |
| Seeking ratio, delayed vs. immediate footshock | 2.7 | 3.0 | 3.5 | 1.7 | 1.7 | -1.9 | 1.9 | 1.6 |
| Tail length | 2.6 | 7.8 | 9.9 | -3.2 | -1.9 | 2.8 | -2.8 | -3.1 |
| Bone: apparent density | 2.6 | 4.4 | 7.3 | -1.8 | -2.7 | 2.0 | -2.0 | -1.9 |
| Delta distance traveled before/after self-admin | 2.6 | 2.8 | 3.2 | -1.8 | -1.7 | 1.6 | -1.6 | -1.8 |
| Intermittent access intake escalation | 2.5 | 2.5 | 2.9 | 1.7 | 1.3 | -1.6 | 1.6 | 1.7 |
| Social responses | 2.4 | 3.1 | 3.2 | -1.7 | -1.7 | 1.8 | -1.8 | -1.8 |
| Intermitt. access day 1 inactive lever presses | 2.4 | 2.5 | 3.7 | 1.6 | 1.9 | -1.4 | 1.4 | 1.6 |
| Bone: elastic work | 2.3 | 2.9 | 5.2 | 1.4 | 2.3 | -1.7 | 1.7 | 1.4 |
| Locomotion distance, session 8 | 2.2 | 3.3 | 4.3 | -1.7 | -2.1 | 1.8 | -1.8 | -1.8 |
| Bone: trabecular number | 2.1 | 3.3 | 6.7 | -1.6 | -2.6 | 1.5 | -1.5 | -1.7 |
| Delta ambulatory time before/after self-admin | 2.1 | 2.2 | 2.5 | -1.6 | -1.5 | 1.4 | -1.4 | -1.6 |
| Bone: stiffness | 2.0 | 3.1 | 4.3 | -1.6 | -1.4 | 2.1 | -2.1 | -1.6 |
| Delta time to tail flick, vehicle, before/after SA | 2.0 | 1.9 | 2.0 | 1.4 | 1.3 | -1.4 | 1.4 | 1.4 |
| Body weight | 1.9 | 8.2 | 9.6 | -3.1 | -3.0 | 2.5 | -2.5 | -3.1 |
| Number of responses in last shaping day | 1.9 | 1.9 | 2.7 | 1.1 | 1.3 | -1.7 | 1.7 | 1.1 |
| Bone: cortical thickness | 1.9 | 3.1 | 7.6 | 1.6 | 2.8 | -1.3 | 1.3 | 1.6 |
| Breakpoint value in progressive ratio session | 1.9 | 2.1 | 2.3 | -1.4 | -1.4 | 1.5 | -1.5 | -1.4 |
| Length with tail | 1.8 | 6.4 | 7.8 | -2.8 | -1.9 | 2.6 | -2.6 | -2.7 |
| Pavlov. Cond. latency score | 1.8 | 2.3 | 3.3 | 1.6 | 1.8 | -1.4 | 1.4 | 1.5 |
| Bone: trabecular tissue density | 1.8 | 2.5 | 3.6 | 1.4 | 1.9 | -1.6 | 1.6 | 1.4 |
| Locomotion velocity, session 3 | 1.7 | 1.9 | 4.8 | 1.3 | 2.2 | -0.8 | 0.8 | 1.4 |
| Bone volume | 1.7 | 2.8 | 5.5 | -1.4 | -2.3 | 1.6 | -1.6 | -1.4 |
| Distance traveled before self-admin | 1.6 | 1.7 | 2.5 | 1.3 | 1.6 | -1.1 | 1.1 | 1.3 |
| Length without tail | 1.5 | 3.3 | 3.7 | -1.9 | -1.9 | 1.7 | -1.7 | -1.9 |
| Extensor digitorum longus weight | 1.5 | 6.0 | 15.1 | -1.8 | -3.9 | 2.1 | -2.1 | -1.8 |
| Intermittent access intake day 1-15 change | 1.5 | 1.5 | 2.1 | 1.4 | 0.7 | -1.2 | 1.2 | 1.4 |
| Degree of sensitization stereotypy | 1.5 | 1.6 | 2.0 | -1.2 | -1.4 | 1.2 | -1.2 | -1.2 |
| Bone surface | 1.5 | 2.7 | 5.2 | -1.4 | -2.3 | 1.5 | -1.5 | -1.4 |
| Pavlov. Cond. lever latency | 1.4 | 1.9 | 2.3 | -1.3 | -1.5 | 1.3 | -1.3 | -1.3 |
| Pavlov. Cond. index score | 1.4 | 1.9 | 2.7 | 1.4 | 1.6 | -1.2 | 1.2 | 1.3 |
| Short access day 1 total infusions | 1.4 | 1.5 | 2.0 | 1.2 | 0.8 | -1.4 | 1.4 | 1.2 |
| Bone: elastic displacement | 1.4 | 1.5 | 2.5 | 1.0 | 0.9 | -1.6 | 1.6 | 0.9 |
| Liver weight, left | 1.3 | 2.1 | 2.9 | -1.6 | -0.9 | 1.5 | -1.5 | -1.7 |
| Pavlov. Cond. lever-magazine prob. diff. | 1.3 | 1.7 | 2.4 | 1.3 | 1.6 | -1.2 | 1.2 | 1.3 |
| Condit. Reinf. lever presses | 1.3 | 1.8 | 2.0 | -1.4 | -1.1 | 1.3 | -1.3 | -1.4 |
| Diff in mean of infusions in LGA sessions | 1.3 | 1.5 | 1.8 | -1.3 | -1.0 | 1.2 | -1.2 | -1.3 |
| Extinction: sum of active levers before priming | 1.3 | 1.3 | 2.2 | -1.3 | -1.5 | 0.8 | -0.8 | -1.3 |
| Liver weight, right | 1.2 | 2.0 | 2.5 | -1.6 | -1.1 | 1.4 | -1.4 | -1.6 |
| Delay discounting water rate 18 sec | 1.2 | 1.6 | 3.2 | -1.0 | -1.8 | 1.1 | -1.1 | -1.2 |
| Intermitt. access day 15 inactive lever presses | 1.2 | 1.3 | 1.7 | 1.0 | 1.1 | -1.3 | 1.3 | 1.1 |
| Context. condit. distance diff. score | 1.2 | 1.5 | 2.1 | -1.1 | -1.4 | 1.2 | -1.2 | -1.1 |
| Degree of sensitization distance | 1.2 | 1.2 | 1.8 | -1.2 | -1.3 | 0.9 | -0.9 | -1.2 |
| Delta time in open arm before/after self-admin | 1.2 | 1.1 | 1.4 | -1.1 | -1.2 | 0.9 | -0.9 | -1.1 |
| Run reversals in cocaine runway, females | 1.2 | 1.2 | 1.7 | 1.1 | 0.7 | -1.3 | 1.3 | 1.1 |
| Condit. Reinf. lever presses | 1.1 | 1.5 | 2.0 | 1.2 | 0.9 | -1.4 | 1.4 | 1.2 |
| Pavlov. Cond. latency score | 1.1 | 1.4 | 1.7 | -1.3 | -0.8 | 1.2 | -1.2 | -1.2 |
| Ambulatory time before self-admin | 1.1 | 1.2 | 2.3 | 1.1 | 1.5 | -0.8 | 0.8 | 1.1 |
| Ambulatory time after self-admin | 1.1 | 1.2 | 1.5 | -1.2 | -0.6 | 1.1 | -1.1 | -1.2 |
| Area under the delay curve | 1.1 | 1.2 | 1.8 | 0.8 | 1.3 | -1.1 | 1.1 | 1.0 |
| Delay disc. indifference point, 2s delay | 1.1 | 1.2 | 1.5 | 0.8 | 1.2 | -1.2 | 1.2 | 1.1 |
| Intraocular pressure | 1.0 | 1.4 | 2.2 | 1.5 | 0.6 | -1.2 | 1.2 | 1.4 |
| Intermittent access day 15 total locomotion | 1.0 | 1.0 | 1.4 | 0.9 | 0.8 | -1.2 | 1.2 | 0.9 |
| Progressive ratio test 1 inactive lever presses | 1.0 | 1.1 | 1.4 | 0.9 | 0.9 | -1.2 | 1.2 | 1.1 |
| Stereotopy head waving duration, day 7 | 1.0 | 1.2 | 1.7 | -0.9 | -1.3 | 1.1 | -1.1 | -1.0 |
| Time in novel zone, hab. session 2 | 1.0 | 1.0 | 3.0 | 0.6 | 1.7 | -0.7 | 0.7 | 0.7 |
| Bone: cortical area | 1.0 | 1.5 | 3.1 | 1.2 | 1.7 | -0.9 | 0.9 | 1.2 |
| Delay discount hyperbolic model param | 1.0 | 1.0 | 1.6 | -0.7 | -1.3 | 1.0 | -1.0 | -0.9 |
| Fe content in liver | 1.0 | 1.2 | 2.0 | -0.8 | -0.6 | 1.4 | -1.4 | -0.9 |
| Na content in liver | 1.0 | 1.0 | 2.3 | 0.6 | 1.5 | -1.0 | 1.0 | 0.6 |
| Indifference point AUC | 0.9 | 1.1 | 1.4 | 1.1 | 0.8 | -1.0 | 1.0 | 1.2 |
| Delay discounting total patch changes 24 sec | 0.9 | 1.1 | 1.4 | 0.9 | 1.2 | -1.1 | 1.1 | 0.8 |
| Pavlov. Cond. intertrial magazine entries | 0.9 | 1.1 | 2.4 | -0.8 | -1.5 | 1.0 | -1.0 | -0.8 |
| Short access total locomotion | 0.9 | 0.9 | 1.3 | 0.8 | 0.8 | -1.1 | 1.1 | 0.8 |
| Bone: post-yield work | 0.9 | 1.3 | 2.2 | -0.8 | -0.8 | 1.5 | -1.5 | -0.8 |
| Active lever presses in extinction session 6 | 0.9 | 0.9 | 1.4 | -0.9 | -1.2 | 0.8 | -0.8 | -0.9 |
| Time in open arm after self-admin | 0.9 | 1.0 | 1.5 | 0.8 | 1.2 | -1.1 | 1.1 | 0.8 |
| Delay discount exponential model param | 0.9 | 0.9 | 1.5 | -0.7 | -1.2 | 1.0 | -1.0 | -0.9 |
| Light reinforcement 2 | 0.8 | 1.0 | 2.3 | 0.7 | 1.5 | -1.0 | 1.0 | 0.7 |
| Cocaine response after cond. not corrected | 0.8 | 0.9 | 1.0 | -1.0 | -0.9 | 1.0 | -1.0 | -1.0 |
| Cocaine response before conditioning | 0.8 | 0.9 | 1.3 | -0.9 | -1.2 | 0.9 | -0.9 | -0.9 |
| Progressive ratio test 2 inactive lever presses | 0.8 | 1.0 | 1.5 | 0.8 | 0.5 | -1.2 | 1.2 | 0.9 |
| Short access day 1 locomotion | 0.8 | 0.8 | 1.1 | 0.7 | 0.7 | -1.1 | 1.1 | 0.8 |
| Locomotion distance, session 2 | 0.8 | 1.1 | 2.0 | -0.8 | -1.4 | 1.0 | -1.0 | -0.9 |
| Pavlov. Cond. magazine entry latency | 0.8 | 1.1 | 1.3 | -1.1 | -0.9 | 1.1 | -1.1 | -1.0 |
| Pavlov. Cond. index score | 0.8 | 1.1 | 1.4 | -1.2 | -0.8 | 1.0 | -1.0 | -1.1 |
| Delay disc. indifference point, 16s delay | 0.8 | 0.8 | 1.0 | 0.7 | 1.0 | -1.0 | 1.0 | 0.9 |
| Distance moved, locomotor task time 2 | 0.8 | 0.9 | 1.2 | 0.8 | 0.7 | -1.1 | 1.1 | 0.9 |
| K content in liver | 0.8 | 0.8 | 1.4 | -1.2 | -0.2 | 0.9 | -0.9 | -1.2 |
| Delay discounting total patch changes 6 sec | 0.7 | 1.1 | 1.6 | 1.0 | 0.7 | -1.3 | 1.3 | 0.9 |
| Reaction time num false alarms | 0.7 | 1.0 | 1.6 | 1.2 | 0.5 | -0.9 | 0.9 | 1.3 |
| Reaction time num false alarms AUC | 0.7 | 0.9 | 1.6 | 1.3 | 0.5 | -0.8 | 0.8 | 1.3 |
| Cocaine induced anxiety | 0.7 | 0.8 | 1.0 | 1.0 | 0.5 | -1.0 | 1.0 | 1.0 |
| Short access total infusions | 0.7 | 0.8 | 1.3 | 0.8 | 0.2 | -1.1 | 1.1 | 0.8 |
| Stereotopy head waving bouts, day 7 | 0.7 | 0.8 | 1.2 | -0.8 | -1.1 | 0.9 | -0.9 | -0.8 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.7 | 0.8 | 1.1 | -1.0 | -0.7 | 0.9 | -0.9 | -1.0 |
| Bone: cortical apparent density | 0.7 | 1.0 | 1.1 | 1.1 | 0.8 | -1.0 | 1.0 | 1.1 |
| Mean time between licks in bursts | 0.6 | 0.8 | 1.0 | -0.9 | -0.6 | 1.0 | -1.0 | -0.9 |
| Reaction time false alarm rate | 0.6 | 0.9 | 1.4 | 1.2 | 0.5 | -0.9 | 0.9 | 1.1 |
| Conditioned locomotion | 0.6 | 0.7 | 1.1 | 1.0 | 0.9 | -0.6 | 0.6 | 1.1 |
| Pavlov. Cond. lever contacts | 0.6 | 0.8 | 1.2 | 0.8 | 1.1 | -0.9 | 0.9 | 0.8 |
| Pavlov. Cond. response bias | 0.6 | 0.9 | 1.6 | 0.8 | 1.3 | -0.9 | 0.9 | 0.8 |
| Intermittent access day 15 total infusions | 0.6 | 0.7 | 1.2 | 0.8 | -0.0 | -1.1 | 1.1 | 0.8 |
| Compulsive drug intake | 0.6 | 0.6 | 0.9 | -0.9 | -0.4 | 0.8 | -0.8 | -1.0 |
| Locomotion velocity, session 2 | 0.6 | 0.6 | 1.0 | -0.8 | -1.0 | 0.7 | -0.7 | -0.8 |
| Total zone transitions, hab. session 2 | 0.6 | 0.7 | 1.2 | -0.7 | -1.1 | 0.9 | -0.9 | -0.7 |
| Bone: tissue strength | 0.6 | 0.5 | 1.8 | 0.7 | 1.3 | -0.1 | 0.1 | 0.7 |
| Time >=10cm from walls, locomotor time 2 | 0.6 | 0.6 | 1.1 | 0.7 | 1.0 | -0.5 | 0.5 | 1.0 |
| Heart weight | 0.5 | 0.7 | 1.2 | -0.6 | -0.5 | 1.1 | -1.1 | -0.7 |
| Tibia length | 0.5 | 1.5 | 1.9 | -1.4 | -0.3 | 1.3 | -1.3 | -1.4 |
| Water consumed over 24 hours | 0.5 | 0.6 | 0.9 | -0.8 | -0.2 | 0.9 | -0.9 | -0.8 |
| Indifference point function ln k | 0.5 | 0.7 | 1.0 | -0.9 | -1.0 | 0.7 | -0.7 | -0.9 |
| Indifference point function log k | 0.5 | 0.7 | 1.0 | -0.9 | -1.0 | 0.7 | -0.7 | -0.9 |
| Reaction time mean AUC | 0.5 | 0.7 | 1.2 | 0.8 | 0.7 | -0.7 | 0.7 | 1.1 |
| Short access day 10 total locomotion | 0.5 | 0.5 | 0.8 | 0.7 | 0.9 | -0.7 | 0.7 | 0.6 |
| Locomotion distance, session 7 | 0.5 | 0.6 | 1.6 | -0.6 | -1.3 | 0.6 | -0.6 | -0.6 |
| Novel to familiar place preference ratio | 0.5 | 0.6 | 0.6 | 0.8 | 0.6 | -0.8 | 0.8 | 0.8 |
| Locomotion velocity, NPP test | 0.5 | 0.8 | 1.0 | 0.9 | 0.5 | -1.0 | 1.0 | 0.9 |
| Bone: cortical tissue density | 0.5 | 0.7 | 0.8 | 0.9 | 0.6 | -0.8 | 0.8 | 0.9 |
| Bone: trabecular spacing | 0.5 | 0.7 | 1.1 | 0.7 | 1.1 | -0.8 | 0.8 | 0.7 |
| Delta time in closed arm before/after self-admin | 0.5 | 0.5 | 0.5 | 0.7 | 0.7 | -0.7 | 0.7 | 0.7 |
| Time to tail flick, test, after self-admin | 0.5 | 0.5 | 0.7 | -0.8 | -0.6 | 0.6 | -0.6 | -0.8 |
| Delay disc. indifference point, 8s delay | 0.5 | 0.5 | 0.7 | 0.5 | 0.9 | -0.8 | 0.8 | 0.6 |
| BMI with tail | 0.4 | 1.2 | 2.8 | -1.0 | -1.7 | 0.9 | -0.9 | -1.0 |
| Delay discounting total patch changes 12 sec | 0.4 | 0.5 | 0.6 | 0.5 | 0.8 | -0.8 | 0.8 | 0.5 |
| Pavlov. Cond. change in total contacts | 0.4 | 0.6 | 1.3 | 0.8 | 1.1 | -0.4 | 0.4 | 0.7 |
| Pavlov. Cond. magazine entry number | 0.4 | 0.5 | 1.3 | -0.6 | -1.2 | 0.4 | -0.4 | -0.6 |
| Conditioned reinforcement - actives | 0.4 | 0.4 | 1.3 | -0.4 | -1.1 | 0.3 | -0.3 | -0.4 |
| Lifetime Intake | 0.4 | 0.4 | 0.8 | 0.4 | -0.1 | -0.9 | 0.9 | 0.4 |
| Pavlov. Cond. response bias | 0.4 | 0.5 | 0.7 | -0.8 | -0.6 | 0.6 | -0.6 | -0.8 |
| Rest time, locomotor task time 1 | 0.4 | 0.5 | 0.6 | 0.8 | 0.3 | -0.8 | 0.8 | 0.6 |
| Cd content in liver | 0.4 | 0.4 | 1.0 | -0.4 | -1.0 | 0.6 | -0.6 | -0.5 |
| BMI without tail | 0.3 | 0.7 | 0.9 | -0.9 | -0.9 | 0.7 | -0.7 | -0.9 |
| Left kidney weight | 0.3 | 0.7 | 3.4 | 0.3 | 1.8 | -0.3 | 0.3 | 0.3 |
| Food consumed during 24 hour testing period | 0.3 | 0.4 | 0.5 | -0.5 | -0.6 | 0.7 | -0.7 | -0.5 |
| Mean num. licks in bursts | 0.3 | 0.4 | 0.5 | -0.7 | -0.2 | 0.7 | -0.7 | -0.7 |
| Delay discounting water rate 6 sec | 0.3 | 0.5 | 0.7 | 0.8 | 0.7 | -0.6 | 0.6 | 0.8 |
| Reaction time mean minus median | 0.3 | 0.4 | 1.0 | 0.7 | 0.4 | -0.4 | 0.4 | 1.0 |
| Reaction time premature initiations | 0.3 | 0.4 | 0.6 | -0.4 | -0.8 | 0.7 | -0.7 | -0.4 |
| Std. dev. reaction times | 0.3 | 0.4 | 1.1 | 0.7 | 0.4 | -0.5 | 0.5 | 1.0 |
| Cocaine response after cond. corrected | 0.3 | 0.4 | 0.4 | -0.7 | -0.5 | 0.5 | -0.5 | -0.7 |
| Conditioned locomotion | 0.3 | 0.4 | 0.6 | 0.4 | 0.6 | -0.8 | 0.8 | 0.4 |
| Intermittent access total infusions | 0.3 | 0.3 | 0.7 | 0.3 | -0.2 | -0.9 | 0.9 | 0.3 |
| Progressive ratio test 1 breakpoint | 0.3 | 0.3 | 0.8 | -0.6 | -0.9 | 0.2 | -0.2 | -0.6 |
| One hour access (shock baseline) | 0.3 | 0.4 | 0.6 | 0.5 | -0.2 | -0.8 | 0.8 | 0.6 |
| Locomotion distance, session 1 | 0.3 | 0.4 | 0.7 | -0.4 | -0.8 | 0.6 | -0.6 | -0.5 |
| Stereotopy head waving bouts, day 3 | 0.3 | 0.4 | 0.6 | -0.5 | -0.2 | 0.8 | -0.8 | -0.5 |
| Stereotopy head waving duration, day 3 | 0.3 | 0.3 | 0.4 | 0.6 | 0.6 | -0.5 | 0.5 | 0.6 |
| Time in familiar zone, hab. session 2 | 0.3 | 0.3 | 1.2 | -0.3 | -1.1 | 0.4 | -0.4 | -0.4 |
| Pavlov. Cond. intertrial magazine entries | 0.3 | 0.4 | 0.6 | 0.7 | 0.1 | -0.7 | 0.7 | 0.7 |
| Bone: maximum diameter | 0.3 | 0.5 | 0.8 | 0.9 | 0.5 | -0.6 | 0.6 | 0.9 |
| Time to tail flick, test, before self-admin | 0.3 | 0.3 | 0.5 | -0.6 | -0.7 | 0.3 | -0.3 | -0.6 |
| Delay disc. indifference point, 4s delay | 0.3 | 0.3 | 0.7 | 0.2 | 0.8 | -0.6 | 0.6 | 0.4 |
| Vertical activity count, locomotor time 2 | 0.3 | 0.3 | 0.5 | 0.4 | 0.7 | -0.5 | 0.5 | 0.5 |
| Weight adjusted by age | 0.3 | 0.4 | 0.8 | -0.6 | -0.9 | 0.4 | -0.4 | -0.6 |
| Progressive ratio | 0.3 | 0.4 | 0.7 | 0.5 | 0.1 | -0.8 | 0.8 | 0.6 |
| Right kidney weight | 0.2 | 0.4 | 2.1 | 0.0 | 1.5 | 0.1 | -0.1 | -0.0 |
| Number of licking bursts | 0.2 | 0.3 | 0.5 | 0.6 | 0.7 | -0.3 | 0.3 | 0.6 |
| Times rat made contact with spout | 0.2 | 0.2 | 0.5 | -0.1 | 0.7 | 0.6 | -0.6 | -0.1 |
| Delay discounting total patch changes 18 sec | 0.2 | 0.3 | 0.7 | 0.4 | 0.9 | -0.4 | 0.4 | 0.3 |
| Reaction time number correct | 0.2 | 0.2 | 0.4 | -0.4 | -0.3 | 0.6 | -0.6 | -0.3 |
| Reaction time trials correct on left | 0.2 | 0.2 | 0.4 | -0.4 | -0.3 | 0.6 | -0.6 | -0.3 |
| Condit. Reinf. active minus inactive responses | 0.2 | 0.3 | 0.4 | -0.3 | -0.6 | 0.6 | -0.6 | -0.4 |
| Condit. Reinf. inactive responses | 0.2 | 0.2 | 0.5 | 0.3 | -0.7 | -0.4 | 0.4 | 0.3 |
| Pavlov. Cond. magazine entry latency | 0.2 | 0.2 | 0.8 | 0.3 | 0.9 | -0.2 | 0.2 | 0.3 |
| Intermittent access day 1 total infusions | 0.2 | 0.2 | 0.5 | -0.5 | -0.7 | -0.0 | 0.0 | -0.5 |
| Intermittent access terminal intake (last 3 days) | 0.2 | 0.2 | 0.9 | -0.3 | -0.9 | -0.1 | 0.1 | -0.3 |
| Intermittent access total locomotion | 0.2 | 0.3 | 0.5 | 0.4 | 0.3 | -0.7 | 0.7 | 0.3 |
| Baseline Anxiety | 0.2 | 0.2 | 0.2 | -0.5 | -0.3 | 0.4 | -0.4 | -0.5 |
| Progressive ratio test 2 active lever presses | 0.2 | 0.2 | 0.4 | 0.3 | -0.1 | -0.6 | 0.6 | 0.3 |
| Progressive ratio test 2 breakpoint | 0.2 | 0.3 | 0.5 | 0.4 | -0.1 | -0.7 | 0.7 | 0.4 |
| Short access day 1 total inactive lever presses | 0.2 | 0.2 | 0.3 | -0.5 | -0.5 | 0.3 | -0.3 | -0.5 |
| One hour access (0.3 mA shock) | 0.2 | 0.2 | 0.4 | 0.2 | -0.5 | -0.6 | 0.6 | 0.1 |
| Locomotion velocity, session 7 | 0.2 | 0.2 | 0.7 | -0.3 | -0.8 | 0.4 | -0.4 | -0.4 |
| Condit. Reinf. inactive responses | 0.2 | 0.3 | 1.1 | 0.2 | -1.0 | -0.1 | 0.1 | 0.3 |
| Incentive salience index mean | 0.2 | 0.2 | 0.3 | -0.5 | -0.2 | 0.5 | -0.5 | -0.5 |
| Time in familiar zone, hab. session 1 | 0.2 | 0.2 | 0.2 | 0.5 | -0.3 | -0.5 | 0.5 | 0.4 |
| Total locomotion distance, hab. session 2 | 0.2 | 0.3 | 0.5 | -0.4 | -0.4 | 0.7 | -0.7 | -0.4 |
| Locomotion velocity, hab. session 2 | 0.2 | 0.3 | 0.4 | -0.3 | -0.4 | 0.7 | -0.7 | -0.4 |
| Pavlov. Cond. lever latency | 0.2 | 0.2 | 0.3 | 0.5 | 0.0 | -0.6 | 0.6 | 0.5 |
| Pavlov. Cond. lever contacts | 0.2 | 0.3 | 0.4 | -0.6 | -0.1 | 0.5 | -0.5 | -0.6 |
| Pavlov. Cond. magazine entry number | 0.2 | 0.2 | 0.3 | 0.6 | 0.5 | -0.4 | 0.4 | 0.5 |
| Bone: final force | 0.2 | 0.3 | 0.5 | -0.4 | 0.5 | 0.7 | -0.7 | -0.4 |
| Bone: periosteal estimation | 0.2 | 0.4 | 0.8 | 0.6 | 0.9 | -0.4 | 0.4 | 0.6 |
| Bone: periosteal perimeter | 0.2 | 0.4 | 0.6 | 0.8 | 0.6 | -0.5 | 0.5 | 0.8 |
| Bone: trabecular thickness | 0.2 | 0.3 | 0.4 | -0.3 | -0.6 | 0.6 | -0.6 | -0.3 |
| Delay disc. indifference point, 24s delay | 0.2 | 0.2 | 0.3 | 0.3 | 0.5 | -0.5 | 0.5 | 0.5 |
| Vertical activity count, locomotor time 1 | 0.2 | 0.2 | 0.5 | -0.4 | -0.7 | 0.4 | -0.4 | -0.3 |
| Run reversals in cocaine runway, males | 0.2 | 0.2 | 0.4 | 0.6 | 0.1 | -0.3 | 0.3 | 0.7 |
| Se content in liver | 0.2 | 0.3 | 0.9 | 0.5 | 0.9 | -0.2 | 0.2 | 0.4 |
| Sr content in liver | 0.2 | 0.2 | 0.7 | -0.5 | -0.8 | 0.1 | -0.1 | -0.4 |
| Std. dev. time between licks in bursts | 0.1 | 0.1 | 0.2 | -0.2 | -0.5 | 0.4 | -0.4 | -0.2 |
| Delay discounting time to switch 0 sec | 0.1 | 0.1 | 0.3 | -0.4 | 0.5 | -0.2 | 0.2 | -0.5 |
| Delay discounting water rate 0 sec | 0.1 | 0.2 | 0.4 | 0.6 | -0.0 | -0.1 | 0.1 | 0.6 |
| Delay discounting water rate 24 sec | 0.1 | 0.1 | 0.2 | 0.1 | -0.1 | -0.4 | 0.4 | 0.2 |
| Locomotor activity | 0.1 | 0.1 | 0.4 | -0.3 | -0.2 | 0.2 | -0.2 | -0.6 |
| Reaction time mean minus median AUC | 0.1 | 0.2 | 0.4 | 0.3 | -0.5 | 0.1 | -0.1 | 0.6 |
| Reaction time trials on left | 0.1 | 0.2 | 0.4 | -0.4 | -0.3 | 0.6 | -0.6 | -0.3 |
| Reaction time mean | 0.1 | 0.2 | 0.4 | 0.4 | 0.4 | -0.3 | 0.3 | 0.7 |
| Median of all reaction times | 0.1 | 0.2 | 0.3 | 0.3 | 0.5 | -0.3 | 0.3 | 0.6 |
| Reaction time premature initiation rate | 0.1 | 0.2 | 0.5 | -0.3 | -0.7 | 0.4 | -0.4 | -0.3 |
| Reaction time trials completed | 0.1 | 0.2 | 0.4 | -0.4 | -0.3 | 0.6 | -0.6 | -0.3 |
| Reaction time trials AUC | 0.1 | 0.2 | 0.3 | -0.3 | -0.3 | 0.6 | -0.6 | -0.2 |
| Saline control response | 0.1 | 0.1 | 0.4 | -0.2 | -0.6 | 0.2 | -0.2 | -0.2 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.1 | -0.2 | -0.0 | 0.4 | -0.4 | -0.2 |
| Condit. Reinf. active responses | 0.1 | 0.1 | 0.6 | -0.1 | -0.7 | 0.2 | -0.2 | -0.1 |
| Condit. Reinf. lever reinforcers received | 0.1 | 0.1 | 0.3 | 0.1 | -0.6 | 0.1 | -0.1 | 0.0 |
| Conditioned reinforcement - inactives | 0.1 | 0.1 | 0.2 | 0.0 | -0.5 | -0.2 | 0.2 | 0.1 |
| Intermittent access day 1 locomotion | 0.1 | 0.1 | 0.3 | 0.1 | 0.4 | -0.5 | 0.5 | 0.1 |
| Post-drug Anxiety | 0.1 | 0.1 | 0.2 | 0.2 | -0.1 | -0.5 | 0.5 | 0.2 |
| Incentive Sensitization - Responses | 0.1 | 0.1 | 0.2 | 0.5 | 0.0 | -0.3 | 0.3 | 0.4 |
| Incentive Sensitization - Breakpoint | 0.1 | 0.1 | 0.2 | 0.5 | 0.1 | -0.3 | 0.3 | 0.4 |
| Progressive ratio test 1 active lever presses | 0.1 | 0.1 | 0.3 | -0.3 | -0.5 | -0.1 | 0.1 | -0.3 |
| Short access day 10 total infusions | 0.1 | 0.1 | 0.2 | 0.1 | -0.4 | -0.5 | 0.5 | 0.1 |
| Locomotion distance, session 3 | 0.1 | 0.1 | 0.2 | 0.4 | 0.3 | -0.2 | 0.2 | 0.5 |
| Locomotion velocity, session 8 | 0.1 | 0.1 | 0.3 | -0.3 | -0.6 | 0.1 | -0.1 | -0.4 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.2 | 0.6 | -0.2 | 0.8 | 0.2 | -0.2 | -0.2 |
| Condit. Reinf. active responses | 0.1 | 0.1 | 0.3 | -0.2 | -0.5 | 0.4 | -0.4 | -0.2 |
| Time in novel zone, hab. session 1 | 0.1 | 0.1 | 0.2 | -0.4 | 0.3 | 0.2 | -0.2 | -0.3 |
| Total zone transitions, hab. session 1 | 0.1 | 0.1 | 0.7 | 0.1 | -0.8 | -0.1 | 0.1 | 0.1 |
| Total locomotion distance, hab. session 1 | 0.1 | 0.2 | 0.5 | -0.2 | -0.7 | 0.4 | -0.4 | -0.2 |
| Locomotion velocity, hab. session 1 | 0.1 | 0.1 | 0.4 | -0.1 | -0.7 | 0.3 | -0.3 | -0.1 |
| Novelty place preference | 0.1 | 0.1 | 0.2 | 0.4 | 0.3 | -0.4 | 0.4 | 0.4 |
| Total zone transitions, NPP test | 0.1 | 0.1 | 0.6 | -0.1 | -0.8 | 0.1 | -0.1 | -0.2 |
| Total locomotion distance, NPP test | 0.1 | 0.2 | 0.3 | 0.5 | -0.0 | -0.6 | 0.6 | 0.4 |
| Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.4 | 0.3 | 0.7 | -0.2 | 0.2 | 0.3 |
| Bone: cortical porosity | 0.1 | 0.1 | 0.2 | -0.4 | -0.4 | 0.3 | -0.3 | -0.5 |
| Bone: cortical thickness | 0.1 | 0.1 | 0.5 | -0.0 | 0.7 | -0.0 | 0.0 | -0.0 |
| Bone: final moment | 0.1 | 0.2 | 0.3 | -0.2 | 0.5 | 0.5 | -0.5 | -0.2 |
| Bone: maximum force | 0.1 | 0.2 | 0.6 | -0.0 | 0.8 | 0.4 | -0.4 | -0.0 |
| Bone: maximum moment | 0.1 | 0.2 | 0.7 | 0.2 | 0.8 | 0.2 | -0.2 | 0.2 |
| Bone: minimum diameter | 0.1 | 0.2 | 0.8 | 0.2 | 0.9 | 0.0 | -0.0 | 0.3 |
| Fecal boli incidents, locomotor time 1 | 0.1 | 0.1 | 0.1 | -0.2 | -0.3 | 0.3 | -0.3 | -0.4 |
| Time >=10cm from walls, locomotor time 1 | 0.1 | 0.1 | 0.1 | 0.2 | -0.1 | -0.2 | 0.2 | 0.3 |
| Bouts of movement, locomotor time 2 | 0.1 | 0.1 | 0.1 | -0.0 | 0.3 | -0.3 | 0.3 | 0.2 |
| Locomotion in novel chamber post-restriction | 0.1 | 0.1 | 0.1 | 0.3 | 0.0 | -0.4 | 0.4 | 0.3 |
| Food seeking constrained by brief footshock | 0.1 | 0.2 | 0.2 | 0.3 | 0.4 | -0.4 | 0.4 | 0.4 |
| Seeking ratio, punishment vs. effort | 0.1 | 0.1 | 0.2 | -0.1 | 0.4 | 0.4 | -0.4 | -0.1 |
| Latency to leave start box in cocaine runway, M | 0.1 | 0.1 | 0.2 | -0.1 | -0.1 | 0.4 | -0.4 | -0.3 |
| Co content in liver | 0.1 | 0.1 | 0.2 | 0.4 | 0.4 | -0.2 | 0.2 | 0.4 |
| Cu content in liver | 0.1 | 0.2 | 0.5 | 0.3 | 0.7 | -0.3 | 0.3 | 0.3 |
| Mg content in liver | 0.1 | 0.1 | 0.3 | 0.2 | 0.3 | -0.5 | 0.5 | 0.1 |
| Mn content in liver | 0.1 | 0.1 | 0.2 | -0.4 | -0.5 | 0.0 | -0.0 | -0.4 |
| Rb content in liver | 0.1 | 0.1 | 0.6 | -0.2 | -0.8 | 0.0 | -0.0 | -0.2 |
| Retroperitoneal fat weight | 0.0 | 0.1 | 0.2 | -0.0 | -0.0 | 0.5 | -0.5 | 0.1 |
| Indifference point 0 sec | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | -0.1 | 0.1 | -0.2 |
| Delay discounting total patch changes 0 sec | 0.0 | 0.0 | 0.1 | -0.1 | -0.3 | -0.2 | 0.2 | -0.1 |
| Delay discounting water rate 12 sec | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | -0.1 | 0.1 | -0.2 |
| Locomotor testing distance | 0.0 | 0.1 | 0.2 | -0.1 | -0.1 | 0.3 | -0.3 | -0.4 |
| Locomotor testing rearing | 0.0 | 0.1 | 0.1 | 0.1 | -0.3 | -0.3 | 0.3 | 0.0 |
| Light reinforcement 1 | 0.0 | 0.1 | 0.1 | -0.1 | -0.1 | -0.4 | 0.4 | -0.1 |
| Reaction time omissions | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | 0.1 |
| Total sessions with >9 infusions | 0.0 | 0.0 | 0.1 | -0.2 | -0.2 | -0.2 | 0.2 | -0.2 |
| Short access day 10 total inactive lever presses | 0.0 | 0.0 | 0.1 | -0.2 | 0.3 | 0.1 | -0.1 | -0.0 |
| Condit. Reinf. active minus inactive responses | 0.0 | 0.0 | 0.0 | -0.1 | 0.2 | 0.1 | -0.1 | -0.1 |
| Time in novel zone, NPP test | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | -0.2 | 0.2 | 0.1 |
| Bone: cortical porosity | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | 0.0 | -0.0 | -0.2 |
| Bone: endosteal estimation | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | -0.0 | 0.0 | 0.1 |
| Bone: endosteal perimeter | 0.0 | 0.1 | 0.3 | 0.3 | -0.5 | -0.0 | 0.0 | 0.3 |
| Bone: marrow area | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | 0.1 |
| Distance traveled after self-admin | 0.0 | 0.1 | 0.1 | -0.3 | 0.1 | 0.2 | -0.2 | -0.3 |
| Time in closed arm after self-admin | 0.0 | 0.0 | 0.0 | 0.2 | 0.2 | 0.0 | -0.0 | 0.2 |
| Time to tail flick, vehicle, after self-admin | 0.0 | 0.0 | 0.2 | 0.0 | -0.5 | -0.1 | 0.1 | 0.0 |
| Delta time to tail flick, test, before/after SA | 0.0 | 0.0 | 0.0 | 0.2 | -0.0 | 0.0 | -0.0 | 0.2 |
| Delay disc. indifference point, 0s delay | 0.0 | 0.0 | 0.1 | -0.2 | -0.1 | 0.3 | -0.3 | -0.0 |
| Change in fecal boli incidents, locomotor task | 0.0 | 0.0 | 0.2 | -0.1 | 0.4 | -0.0 | 0.0 | -0.0 |
| Bouts of movement, locomotor time 1 | 0.0 | 0.0 | 0.1 | -0.2 | -0.3 | 0.1 | -0.1 | -0.3 |
| Total resting periods, locomotor time 1 | 0.0 | 0.0 | 0.1 | 0.0 | -0.2 | -0.1 | 0.1 | -0.1 |
| Distance moved, locomotor task time 1 | 0.0 | 0.0 | 0.0 | -0.1 | -0.1 | -0.0 | 0.0 | 0.1 |
| Total resting periods, locomotor time 2 | 0.0 | 0.0 | 0.1 | -0.2 | -0.0 | -0.1 | 0.1 | -0.1 |
| Rest time, locomotor task time 2 | 0.0 | 0.0 | 0.1 | 0.2 | -0.4 | 0.0 | -0.0 | -0.2 |
| Latency to leave start box in cocaine runway | 0.0 | 0.0 | 0.1 | 0.0 | 0.3 | 0.0 | -0.0 | -0.0 |
| Latency to leave start box in cocaine runway, F | 0.0 | 0.1 | 0.1 | -0.3 | 0.0 | 0.1 | -0.1 | -0.3 |
| Zn content in liver | 0.0 | 0.1 | 0.1 | 0.1 | -0.4 | -0.2 | 0.2 | 0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.