Hub : Genes

Pitpna

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000003846	0.04	0.03	3.1e-05	0.03	0.03	0.02	0.03	1.1e-04	1.1e-04	1.8e-03	1.5e-04
2	Brain	gene expression	ENSRNOG00000003846	0.03	0.02	7.8e-03	0	0.01	0.01	0	3.1e-01	1.6e-02	4.9e-02	1.1e-01
3	Eye	intron excision ratio	chr10:60430987:60434857	0.24	0.15	3.1e-03	0.34	0.18	0.27	0.3	3.4e-06	9.5e-04	5.1e-05	1.4e-05
4	Eye	intron excision ratio	chr10:60434887:60440812	0.27	0.16	1.8e-03	0.36	0.22	0.3	0.35	1.8e-06	2.3e-04	1.4e-05	2.1e-06
5	Liver	gene expression	ENSRNOG00000003846	0.03	0.02	8.7e-04	0.02	0.01	0.01	0.01	1.7e-03	1.0e-02	4.1e-02	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	0.4	1.2	2.8	-1.0	-1.7	0.9	-0.9	-1.0
BMI without tail	0.3	0.7	0.9	-0.9	-0.9	0.7	-0.7	-0.9
Body weight	1.9	8.2	9.6	-3.1	-3.0	2.5	-2.5	-3.1
Epididymis fat weight	3.6	8.5	10.7	-2.8	-3.3	2.9	-2.9	-2.7
Glucose	2.8	4.2	5.9	1.8	2.4	-2.1	2.1	1.8
Heart weight	0.5	0.7	1.2	-0.6	-0.5	1.1	-1.1	-0.7
Left kidney weight	0.3	0.7	3.4	0.3	1.8	-0.3	0.3	0.3
Right kidney weight	0.2	0.4	2.1	0.0	1.5	0.1	-0.1	-0.0
Tail length	2.6	7.8	9.9	-3.2	-1.9	2.8	-2.8	-3.1
Length with tail	1.8	6.4	7.8	-2.8	-1.9	2.6	-2.6	-2.7
Length without tail	1.5	3.3	3.7	-1.9	-1.9	1.7	-1.7	-1.9
Liver weight, left	1.3	2.1	2.9	-1.6	-0.9	1.5	-1.5	-1.7
Liver weight, right	1.2	2.0	2.5	-1.6	-1.1	1.4	-1.4	-1.6
Parametrial fat weight	9.4	18.3	22.1	-4.4	-4.7	3.9	-3.9	-4.4
Retroperitoneal fat weight	0.0	0.1	0.2	-0.0	-0.0	0.5	-0.5	0.1
Intraocular pressure	1.0	1.4	2.2	1.5	0.6	-1.2	1.2	1.4
Extensor digitorum longus weight	1.5	6.0	15.1	-1.8	-3.9	2.1	-2.1	-1.8
Soleus weight	4.5	13.1	15.1	-3.5	-3.9	3.6	-3.6	-3.4
Tibialis anterior weight	3.5	12.0	26.4	-3.1	-5.1	2.7	-2.7	-3.1
Tibia length	0.5	1.5	1.9	-1.4	-0.3	1.3	-1.3	-1.4
Number of licking bursts	0.2	0.3	0.5	0.6	0.7	-0.3	0.3	0.6
Food consumed during 24 hour testing period	0.3	0.4	0.5	-0.5	-0.6	0.7	-0.7	-0.5
Times rat made contact with spout	0.2	0.2	0.5	-0.1	0.7	0.6	-0.6	-0.1
Mean time between licks in bursts	0.6	0.8	1.0	-0.9	-0.6	1.0	-1.0	-0.9
Mean num. licks in bursts	0.3	0.4	0.5	-0.7	-0.2	0.7	-0.7	-0.7
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.2	-0.5	0.4	-0.4	-0.2
Water consumed over 24 hours	0.5	0.6	0.9	-0.8	-0.2	0.9	-0.9	-0.8
Indifference point 0 sec	0.0	0.0	0.1	-0.2	-0.3	-0.1	0.1	-0.2
Indifference point AUC	0.9	1.1	1.4	1.1	0.8	-1.0	1.0	1.2
Indifference point function ln k	0.5	0.7	1.0	-0.9	-1.0	0.7	-0.7	-0.9
Indifference point function log k	0.5	0.7	1.0	-0.9	-1.0	0.7	-0.7	-0.9
Delay discounting total patch changes 0 sec	0.0	0.0	0.1	-0.1	-0.3	-0.2	0.2	-0.1
Delay discounting total patch changes 12 sec	0.4	0.5	0.6	0.5	0.8	-0.8	0.8	0.5
Delay discounting total patch changes 18 sec	0.2	0.3	0.7	0.4	0.9	-0.4	0.4	0.3
Delay discounting total patch changes 24 sec	0.9	1.1	1.4	0.9	1.2	-1.1	1.1	0.8
Delay discounting total patch changes 6 sec	0.7	1.1	1.6	1.0	0.7	-1.3	1.3	0.9
Delay discounting time to switch 0 sec	0.1	0.1	0.3	-0.4	0.5	-0.2	0.2	-0.5
Delay discounting water rate 0 sec	0.1	0.2	0.4	0.6	-0.0	-0.1	0.1	0.6
Delay discounting water rate 12 sec	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.1	-0.2
Delay discounting water rate 18 sec	1.2	1.6	3.2	-1.0	-1.8	1.1	-1.1	-1.2
Delay discounting water rate 24 sec	0.1	0.1	0.2	0.1	-0.1	-0.4	0.4	0.2
Delay discounting water rate 6 sec	0.3	0.5	0.7	0.8	0.7	-0.6	0.6	0.8
Locomotor activity	0.1	0.1	0.4	-0.3	-0.2	0.2	-0.2	-0.6
Locomotor testing distance	0.0	0.1	0.2	-0.1	-0.1	0.3	-0.3	-0.4
Locomotor testing rearing	0.0	0.1	0.1	0.1	-0.3	-0.3	0.3	0.0
Light reinforcement 1	0.0	0.1	0.1	-0.1	-0.1	-0.4	0.4	-0.1
Light reinforcement 2	0.8	1.0	2.3	0.7	1.5	-1.0	1.0	0.7
Reaction time number correct	0.2	0.2	0.4	-0.4	-0.3	0.6	-0.6	-0.3
Reaction time mean minus median	0.3	0.4	1.0	0.7	0.4	-0.4	0.4	1.0
Reaction time mean minus median AUC	0.1	0.2	0.4	0.3	-0.5	0.1	-0.1	0.6
Reaction time num false alarms	0.7	1.0	1.6	1.2	0.5	-0.9	0.9	1.3
Reaction time num false alarms AUC	0.7	0.9	1.6	1.3	0.5	-0.8	0.8	1.3
Reaction time trials correct on left	0.2	0.2	0.4	-0.4	-0.3	0.6	-0.6	-0.3
Reaction time trials on left	0.1	0.2	0.4	-0.4	-0.3	0.6	-0.6	-0.3
Reaction time mean	0.1	0.2	0.4	0.4	0.4	-0.3	0.3	0.7
Reaction time mean AUC	0.5	0.7	1.2	0.8	0.7	-0.7	0.7	1.1
Median of all reaction times	0.1	0.2	0.3	0.3	0.5	-0.3	0.3	0.6
Reaction time omissions	0.0	0.0	0.0	0.0	0.1	0.2	-0.2	0.1
Reaction time false alarm rate	0.6	0.9	1.4	1.2	0.5	-0.9	0.9	1.1
Reaction time premature initiation rate	0.1	0.2	0.5	-0.3	-0.7	0.4	-0.4	-0.3
Reaction time premature initiations	0.3	0.4	0.6	-0.4	-0.8	0.7	-0.7	-0.4
Std. dev. reaction times	0.3	0.4	1.1	0.7	0.4	-0.5	0.5	1.0
Reaction time trials completed	0.1	0.2	0.4	-0.4	-0.3	0.6	-0.6	-0.3
Reaction time trials AUC	0.1	0.2	0.3	-0.3	-0.3	0.6	-0.6	-0.2
Social response proportion	5.0	5.4	6.3	-2.3	-2.0	2.5	-2.5	-2.3
Social responses	2.4	3.1	3.2	-1.7	-1.7	1.8	-1.8	-1.8
Social time	3.2	4.2	5.1	-2.0	-2.3	2.1	-2.1	-1.9
Conditioned locomotion	0.6	0.7	1.1	1.0	0.9	-0.6	0.6	1.1
Cocaine response after cond. corrected	0.3	0.4	0.4	-0.7	-0.5	0.5	-0.5	-0.7
Cocaine response after cond. not corrected	0.8	0.9	1.0	-1.0	-0.9	1.0	-1.0	-1.0
Cocaine response before conditioning	0.8	0.9	1.3	-0.9	-1.2	0.9	-0.9	-0.9
Saline control response	0.1	0.1	0.4	-0.2	-0.6	0.2	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.3	-0.6	0.6	-0.6	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.2	-0.0	0.4	-0.4	-0.2
Condit. Reinf. active responses	0.1	0.1	0.6	-0.1	-0.7	0.2	-0.2	-0.1
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.3	-0.7	-0.4	0.4	0.3
Condit. Reinf. lever presses	1.1	1.5	2.0	1.2	0.9	-1.4	1.4	1.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.1	-0.6	0.1	-0.1	0.0
Pavlov. Cond. lever latency	1.4	1.9	2.3	-1.3	-1.5	1.3	-1.3	-1.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.8	0.3	0.9	-0.2	0.2	0.3
Pavlov. Cond. change in total contacts	0.4	0.6	1.3	0.8	1.1	-0.4	0.4	0.7
Pavlov. Cond. index score	1.4	1.9	2.7	1.4	1.6	-1.2	1.2	1.3
Pavlov. Cond. latency score	1.8	2.3	3.3	1.6	1.8	-1.4	1.4	1.5
Pavlov. Cond. lever contacts	0.6	0.8	1.2	0.8	1.1	-0.9	0.9	0.8
Pavlov. Cond. magazine entry number	0.4	0.5	1.3	-0.6	-1.2	0.4	-0.4	-0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.4	-0.8	-1.5	1.0	-1.0	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	2.4	1.3	1.6	-1.2	1.2	1.3
Pavlov. Cond. response bias	0.6	0.9	1.6	0.8	1.3	-0.9	0.9	0.8
Conditioned reinforcement - actives	0.4	0.4	1.3	-0.4	-1.1	0.3	-0.3	-0.4
Conditioned reinforcement - inactives	0.1	0.1	0.2	0.0	-0.5	-0.2	0.2	0.1
Conditioned locomotion	0.3	0.4	0.6	0.4	0.6	-0.8	0.8	0.4
Intermittent access intake day 1-15 change	1.5	1.5	2.1	1.4	0.7	-1.2	1.2	1.4
Intermittent access intake escalation	2.5	2.5	2.9	1.7	1.3	-1.6	1.6	1.7
Intermittent access intake escalation 2	3.1	3.0	3.6	1.9	1.6	-1.7	1.7	1.9
Intermitt. access day 1 inactive lever presses	2.4	2.5	3.7	1.6	1.9	-1.4	1.4	1.6
Intermitt. access day 15 inactive lever presses	1.2	1.3	1.7	1.0	1.1	-1.3	1.3	1.1
Intermitt. access escalation Index	6.8	6.0	7.6	-2.4	-1.8	2.8	-2.8	-2.4
Intermittent access day 1 total infusions	0.2	0.2	0.5	-0.5	-0.7	-0.0	0.0	-0.5
Intermittent access day 15 total infusions	0.6	0.7	1.2	0.8	-0.0	-1.1	1.1	0.8
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.9	-0.3	-0.9	-0.1	0.1	-0.3
Intermittent access total infusions	0.3	0.3	0.7	0.3	-0.2	-0.9	0.9	0.3
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.1	0.4	-0.5	0.5	0.1
Intermittent access day 15 total locomotion	1.0	1.0	1.4	0.9	0.8	-1.2	1.2	0.9
Intermittent access total locomotion	0.2	0.3	0.5	0.4	0.3	-0.7	0.7	0.3
Intermittent access standard deviation	4.2	4.5	5.3	2.2	1.4	-2.3	2.3	2.3
Cocaine induced anxiety	0.7	0.8	1.0	1.0	0.5	-1.0	1.0	1.0
Post-drug Anxiety	0.1	0.1	0.2	0.2	-0.1	-0.5	0.5	0.2
Baseline Anxiety	0.2	0.2	0.2	-0.5	-0.3	0.4	-0.4	-0.5
Lifetime Intake	0.4	0.4	0.8	0.4	-0.1	-0.9	0.9	0.4
Incentive Sensitization - Responses	0.1	0.1	0.2	0.5	0.0	-0.3	0.3	0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.5	0.1	-0.3	0.3	0.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.3	-0.5	-0.1	0.1	-0.3
Progressive ratio test 1 breakpoint	0.3	0.3	0.8	-0.6	-0.9	0.2	-0.2	-0.6
Progressive ratio test 1 inactive lever presses	1.0	1.1	1.4	0.9	0.9	-1.2	1.2	1.1
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	0.3	-0.1	-0.6	0.6	0.3
Progressive ratio test 2 breakpoint	0.2	0.3	0.5	0.4	-0.1	-0.7	0.7	0.4
Progressive ratio test 2 inactive lever presses	0.8	1.0	1.5	0.8	0.5	-1.2	1.2	0.9
Total sessions with >9 infusions	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.2
Short access day 1 total inactive lever presses	0.2	0.2	0.3	-0.5	-0.5	0.3	-0.3	-0.5
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.2	0.3	0.1	-0.1	-0.0
Short access day 1 total infusions	1.4	1.5	2.0	1.2	0.8	-1.4	1.4	1.2
Short access day 10 total infusions	0.1	0.1	0.2	0.1	-0.4	-0.5	0.5	0.1
Short access total infusions	0.7	0.8	1.3	0.8	0.2	-1.1	1.1	0.8
Short access day 1 locomotion	0.8	0.8	1.1	0.7	0.7	-1.1	1.1	0.8
Short access day 10 total locomotion	0.5	0.5	0.8	0.7	0.9	-0.7	0.7	0.6
Short access total locomotion	0.9	0.9	1.3	0.8	0.8	-1.1	1.1	0.8
Compulsive drug intake	0.6	0.6	0.9	-0.9	-0.4	0.8	-0.8	-1.0
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.2	-0.5	-0.6	0.6	0.1
One hour access (shock baseline)	0.3	0.4	0.6	0.5	-0.2	-0.8	0.8	0.6
Number of responses in last shaping day	1.9	1.9	2.7	1.1	1.3	-1.7	1.7	1.1
Context. condit. distance diff. score	1.2	1.5	2.1	-1.1	-1.4	1.2	-1.2	-1.1
Locomotion velocity, session 1	4.4	4.7	5.1	-2.1	-2.3	2.2	-2.2	-2.1
Locomotion distance, session 1	0.3	0.4	0.7	-0.4	-0.8	0.6	-0.6	-0.5
Locomotion velocity, session 2	0.6	0.6	1.0	-0.8	-1.0	0.7	-0.7	-0.8
Locomotion distance, session 2	0.8	1.1	2.0	-0.8	-1.4	1.0	-1.0	-0.9
Locomotion velocity, session 3	1.7	1.9	4.8	1.3	2.2	-0.8	0.8	1.4
Locomotion distance, session 3	0.1	0.1	0.2	0.4	0.3	-0.2	0.2	0.5
Stereotopy head waving bouts, day 3	0.3	0.4	0.6	-0.5	-0.2	0.8	-0.8	-0.5
Stereotopy head waving duration, day 3	0.3	0.3	0.4	0.6	0.6	-0.5	0.5	0.6
Locomotion velocity, session 7	0.2	0.2	0.7	-0.3	-0.8	0.4	-0.4	-0.4
Locomotion distance, session 7	0.5	0.6	1.6	-0.6	-1.3	0.6	-0.6	-0.6
Stereotopy head waving bouts, day 7	0.7	0.8	1.2	-0.8	-1.1	0.9	-0.9	-0.8
Stereotopy head waving duration, day 7	1.0	1.2	1.7	-0.9	-1.3	1.1	-1.1	-1.0
Locomotion velocity, session 8	0.1	0.1	0.3	-0.3	-0.6	0.1	-0.1	-0.4
Locomotion distance, session 8	2.2	3.3	4.3	-1.7	-2.1	1.8	-1.8	-1.8
Degree of sensitization distance	1.2	1.2	1.8	-1.2	-1.3	0.9	-0.9	-1.2
Degree of sensitization stereotypy	1.5	1.6	2.0	-1.2	-1.4	1.2	-1.2	-1.2
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.1	0.2	0.1	-0.1	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.6	-0.2	0.8	0.2	-0.2	-0.2
Condit. Reinf. active responses	0.1	0.1	0.3	-0.2	-0.5	0.4	-0.4	-0.2
Condit. Reinf. inactive responses	0.2	0.3	1.1	0.2	-1.0	-0.1	0.1	0.3
Incentive salience index mean	0.2	0.2	0.3	-0.5	-0.2	0.5	-0.5	-0.5
Condit. Reinf. lever presses	1.3	1.8	2.0	-1.4	-1.1	1.3	-1.3	-1.4
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.5	-0.3	-0.5	0.5	0.4
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.4	0.3	0.2	-0.2	-0.3
Total zone transitions, hab. session 1	0.1	0.1	0.7	0.1	-0.8	-0.1	0.1	0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.5	-0.2	-0.7	0.4	-0.4	-0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.4	-0.1	-0.7	0.3	-0.3	-0.1
Time in familiar zone, hab. session 2	0.3	0.3	1.2	-0.3	-1.1	0.4	-0.4	-0.4
Time in novel zone, hab. session 2	1.0	1.0	3.0	0.6	1.7	-0.7	0.7	0.7
Total zone transitions, hab. session 2	0.6	0.7	1.2	-0.7	-1.1	0.9	-0.9	-0.7
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.4	-0.4	0.7	-0.7	-0.4
Locomotion velocity, hab. session 2	0.2	0.3	0.4	-0.3	-0.4	0.7	-0.7	-0.4
Novel to familiar place preference ratio	0.5	0.6	0.6	0.8	0.6	-0.8	0.8	0.8
Novelty place preference	0.1	0.1	0.2	0.4	0.3	-0.4	0.4	0.4
Time in novel zone, NPP test	0.0	0.0	0.1	0.1	0.0	-0.2	0.2	0.1
Total zone transitions, NPP test	0.1	0.1	0.6	-0.1	-0.8	0.1	-0.1	-0.2
Total locomotion distance, NPP test	0.1	0.2	0.3	0.5	-0.0	-0.6	0.6	0.4
Locomotion velocity, NPP test	0.5	0.8	1.0	0.9	0.5	-1.0	1.0	0.9
Pavlov. Cond. lever latency	0.2	0.2	0.3	0.5	0.0	-0.6	0.6	0.5
Pavlov. Cond. magazine entry latency	0.8	1.1	1.3	-1.1	-0.9	1.1	-1.1	-1.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	0.3	0.7	-0.2	0.2	0.3
Pavlov. Cond. index score	0.8	1.1	1.4	-1.2	-0.8	1.0	-1.0	-1.1
Pavlov. Cond. latency score	1.1	1.4	1.7	-1.3	-0.8	1.2	-1.2	-1.2
Pavlov. Cond. lever contacts	0.2	0.3	0.4	-0.6	-0.1	0.5	-0.5	-0.6
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.6	0.5	-0.4	0.4	0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	0.7	0.1	-0.7	0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.1	-1.0	-0.7	0.9	-0.9	-1.0
Pavlov. Cond. response bias	0.4	0.5	0.7	-0.8	-0.6	0.6	-0.6	-0.8
Bone: apparent density	2.6	4.4	7.3	-1.8	-2.7	2.0	-2.0	-1.9
Bone surface	1.5	2.7	5.2	-1.4	-2.3	1.5	-1.5	-1.4
Bone volume	1.7	2.8	5.5	-1.4	-2.3	1.6	-1.6	-1.4
Bone: connectivity density	3.0	4.7	8.7	-1.9	-3.0	2.0	-2.0	-1.9
Bone: cortical apparent density	0.7	1.0	1.1	1.1	0.8	-1.0	1.0	1.1
Bone: cortical area	1.0	1.5	3.1	1.2	1.7	-0.9	0.9	1.2
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.3	-0.5
Bone: cortical porosity	0.0	0.0	0.1	-0.2	-0.1	0.0	-0.0	-0.2
Bone: cortical thickness	1.9	3.1	7.6	1.6	2.8	-1.3	1.3	1.6
Bone: cortical thickness	0.1	0.1	0.5	-0.0	0.7	-0.0	0.0	-0.0
Bone: cortical tissue density	0.5	0.7	0.8	0.9	0.6	-0.8	0.8	0.9
Bone: elastic displacement	1.4	1.5	2.5	1.0	0.9	-1.6	1.6	0.9
Bone: elastic work	2.3	2.9	5.2	1.4	2.3	-1.7	1.7	1.4
Bone: endosteal estimation	0.0	0.0	0.0	0.1	-0.1	-0.0	0.0	0.1
Bone: endosteal perimeter	0.0	0.1	0.3	0.3	-0.5	-0.0	0.0	0.3
Bone: final force	0.2	0.3	0.5	-0.4	0.5	0.7	-0.7	-0.4
Bone: final moment	0.1	0.2	0.3	-0.2	0.5	0.5	-0.5	-0.2
Bone: marrow area	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1
Bone: maximum diameter	0.3	0.5	0.8	0.9	0.5	-0.6	0.6	0.9
Bone: maximum force	0.1	0.2	0.6	-0.0	0.8	0.4	-0.4	-0.0
Bone: maximum moment	0.1	0.2	0.7	0.2	0.8	0.2	-0.2	0.2
Bone: minimum diameter	0.1	0.2	0.8	0.2	0.9	0.0	-0.0	0.3
Bone: periosteal estimation	0.2	0.4	0.8	0.6	0.9	-0.4	0.4	0.6
Bone: periosteal perimeter	0.2	0.4	0.6	0.8	0.6	-0.5	0.5	0.8
Bone: post-yield work	0.9	1.3	2.2	-0.8	-0.8	1.5	-1.5	-0.8
Bone: stiffness	2.0	3.1	4.3	-1.6	-1.4	2.1	-2.1	-1.6
Bone: tissue strength	0.6	0.5	1.8	0.7	1.3	-0.1	0.1	0.7
Bone: trabecular number	2.1	3.3	6.7	-1.6	-2.6	1.5	-1.5	-1.7
Bone: trabecular spacing	0.5	0.7	1.1	0.7	1.1	-0.8	0.8	0.7
Bone: trabecular thickness	0.2	0.3	0.4	-0.3	-0.6	0.6	-0.6	-0.3
Bone: trabecular tissue density	1.8	2.5	3.6	1.4	1.9	-1.6	1.6	1.4
Breakpoint value in progressive ratio session	1.9	2.1	2.3	-1.4	-1.4	1.5	-1.5	-1.4
Distance traveled before self-admin	1.6	1.7	2.5	1.3	1.6	-1.1	1.1	1.3
Distance traveled after self-admin	0.0	0.1	0.1	-0.3	0.1	0.2	-0.2	-0.3
Delta time in closed arm before/after self-admin	0.5	0.5	0.5	0.7	0.7	-0.7	0.7	0.7
Delta time in open arm before/after self-admin	1.2	1.1	1.4	-1.1	-1.2	0.9	-0.9	-1.1
Diff in mean of infusions in LGA sessions	1.3	1.5	1.8	-1.3	-1.0	1.2	-1.2	-1.3
Extinction: sum of active levers before priming	1.3	1.3	2.2	-1.3	-1.5	0.8	-0.8	-1.3
Active lever presses in extinction session 6	0.9	0.9	1.4	-0.9	-1.2	0.8	-0.8	-0.9
Delta distance traveled before/after self-admin	2.6	2.8	3.2	-1.8	-1.7	1.6	-1.6	-1.8
Delta ambulatory time before/after self-admin	2.1	2.2	2.5	-1.6	-1.5	1.4	-1.4	-1.6
Time in closed arm before self-admin	2.9	3.3	3.7	-1.7	-1.9	1.9	-1.9	-1.7
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	0.2	0.0	-0.0	0.2
Time in open arm before self-admin	5.1	5.5	7.7	2.0	2.8	-2.4	2.4	2.0
Time in open arm after self-admin	0.9	1.0	1.5	0.8	1.2	-1.1	1.1	0.8
Sum of active levers in priming session hrs 5-6	2.8	2.7	2.9	-1.7	-1.7	1.6	-1.6	-1.7
Time to tail flick, vehicle, before self-admin	5.0	5.0	7.5	-2.2	-2.7	2.0	-2.0	-2.2
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.2	0.0	-0.5	-0.1	0.1	0.0
Time to tail flick, test, before self-admin	0.3	0.3	0.5	-0.6	-0.7	0.3	-0.3	-0.6
Time to tail flick, test, after self-admin	0.5	0.5	0.7	-0.8	-0.6	0.6	-0.6	-0.8
Delta time to tail flick, vehicle, before/after SA	2.0	1.9	2.0	1.4	1.3	-1.4	1.4	1.4
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.2	-0.0	0.0	-0.0	0.2
Ambulatory time before self-admin	1.1	1.2	2.3	1.1	1.5	-0.8	0.8	1.1
Ambulatory time after self-admin	1.1	1.2	1.5	-1.2	-0.6	1.1	-1.1	-1.2
Total heroin consumption	4.5	5.4	6.0	-2.4	-2.5	2.2	-2.2	-2.4
Area under the delay curve	1.1	1.2	1.8	0.8	1.3	-1.1	1.1	1.0
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.2	-0.1	0.3	-0.3	-0.0
Delay disc. indifference point, 16s delay	0.8	0.8	1.0	0.7	1.0	-1.0	1.0	0.9
Delay disc. indifference point, 2s delay	1.1	1.2	1.5	0.8	1.2	-1.2	1.2	1.1
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.3	0.5	-0.5	0.5	0.5
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	0.2	0.8	-0.6	0.6	0.4
Delay disc. indifference point, 8s delay	0.5	0.5	0.7	0.5	0.9	-0.8	0.8	0.6
Delay discount exponential model param	0.9	0.9	1.5	-0.7	-1.2	1.0	-1.0	-0.9
Delay discount hyperbolic model param	1.0	1.0	1.6	-0.7	-1.3	1.0	-1.0	-0.9
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.3	-0.4
Change in fecal boli incidents, locomotor task	0.0	0.0	0.2	-0.1	0.4	-0.0	0.0	-0.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.2	-0.1	-0.2	0.2	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.1	-0.3
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.0	-0.2	-0.1	0.1	-0.1
Rest time, locomotor task time 1	0.4	0.5	0.6	0.8	0.3	-0.8	0.8	0.6
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.0	0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.5	-0.4	-0.7	0.4	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.1	0.7	1.0	-0.5	0.5	1.0
Bouts of movement, locomotor time 2	0.1	0.1	0.1	-0.0	0.3	-0.3	0.3	0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	-0.0	-0.1	0.1	-0.1
Rest time, locomotor task time 2	0.0	0.0	0.1	0.2	-0.4	0.0	-0.0	-0.2
Distance moved, locomotor task time 2	0.8	0.9	1.2	0.8	0.7	-1.1	1.1	0.9
Vertical activity count, locomotor time 2	0.3	0.3	0.5	0.4	0.7	-0.5	0.5	0.5
Weight adjusted by age	0.3	0.4	0.8	-0.6	-0.9	0.4	-0.4	-0.6
Seeking ratio, delayed vs. immediate footshock	2.7	3.0	3.5	1.7	1.7	-1.9	1.9	1.6
Locomotion in novel chamber	6.1	7.5	8.5	2.8	2.3	-2.9	2.9	2.8
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	0.3	0.0	-0.4	0.4	0.3
Progressive ratio	0.3	0.4	0.7	0.5	0.1	-0.8	0.8	0.6
Food seeking constrained by brief footshock	0.1	0.2	0.2	0.3	0.4	-0.4	0.4	0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.1	0.4	0.4	-0.4	-0.1
Run reversals in cocaine runway, females	1.2	1.2	1.7	1.1	0.7	-1.3	1.3	1.1
Run reversals in cocaine runway, males	0.2	0.2	0.4	0.6	0.1	-0.3	0.3	0.7
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.0	0.3	0.0	-0.0	-0.0
Latency to leave start box in cocaine runway, F	0.0	0.1	0.1	-0.3	0.0	0.1	-0.1	-0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.1	-0.1	0.4	-0.4	-0.3
Cd content in liver	0.4	0.4	1.0	-0.4	-1.0	0.6	-0.6	-0.5
Co content in liver	0.1	0.1	0.2	0.4	0.4	-0.2	0.2	0.4
Cu content in liver	0.1	0.2	0.5	0.3	0.7	-0.3	0.3	0.3
Fe content in liver	1.0	1.2	2.0	-0.8	-0.6	1.4	-1.4	-0.9
K content in liver	0.8	0.8	1.4	-1.2	-0.2	0.9	-0.9	-1.2
Mg content in liver	0.1	0.1	0.3	0.2	0.3	-0.5	0.5	0.1
Mn content in liver	0.1	0.1	0.2	-0.4	-0.5	0.0	-0.0	-0.4
Na content in liver	1.0	1.0	2.3	0.6	1.5	-1.0	1.0	0.6
Rb content in liver	0.1	0.1	0.6	-0.2	-0.8	0.0	-0.0	-0.2
Se content in liver	0.2	0.3	0.9	0.5	0.9	-0.2	0.2	0.4
Sr content in liver	0.2	0.2	0.7	-0.5	-0.8	0.1	-0.1	-0.4
Zn content in liver	0.0	0.1	0.1	0.1	-0.4	-0.2	0.2	0.2