Hub : Genes

Endov

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000003699	0.04	0.04	1.7e-03	0.02	0.01	0.02	0.01	2.0e-03	1.2e-02	6.5e-03	9.9e-03
2	Liver	gene expression	ENSRNOG00000003699	0.06	0.04	6.3e-06	0.04	0.05	0.06	0.05	9.3e-06	5.2e-06	8.2e-07	2.8e-06
3	PL	gene expression	ENSRNOG00000003699	0.04	0.03	2.5e-03	0.04	0.04	0.04	0.04	3.1e-04	5.9e-04	4.9e-04	2.5e-04
4	PL	intron excision ratio	chr10:104760201:104768396	0.03	0.02	9.9e-03	0.02	0.01	0	-0	1.2e-02	4.7e-02	1.6e-01	4.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	0.6	2.1	4.8	0.9	-0.5	-2.2	1.6
BMI without tail	4.5	9.4	19.2	1.3	-1.7	-4.4	3.7
Body weight	3.0	12.7	24.4	-2.0	-3.5	-3.2	4.9
Epididymis fat weight	1.0	2.4	4.4	0.1	-0.8	-2.1	2.1
Glucose	2.5	3.8	7.9	0.5	0.9	2.8	-2.5
Heart weight	0.4	0.5	0.9	0.6	-0.9	-0.6	0.7
Left kidney weight	1.0	2.9	8.0	-2.8	-1.2	1.3	0.6
Right kidney weight	0.6	1.6	4.3	-2.1	-0.9	1.1	0.5
Tail length	4.4	13.2	25.0	-1.2	-4.0	-3.2	5.0
Length with tail	2.7	9.9	14.5	-3.4	-3.5	-1.0	3.8
Length without tail	1.8	3.9	9.8	-3.1	-0.8	2.2	-0.2
Liver weight, left	0.8	1.2	3.6	-1.9	-0.1	1.2	-0.1
Liver weight, right	2.5	4.2	8.4	-1.7	-2.9	-0.2	2.3
Parametrial fat weight	1.4	2.7	5.6	-0.3	-2.4	-1.0	2.1
Retroperitoneal fat weight	3.8	12.5	25.3	-1.0	-3.2	-3.7	5.0
Intraocular pressure	0.8	1.1	3.0	1.7	-0.5	-1.0	0.6
Extensor digitorum longus weight	0.7	3.0	6.4	2.5	0.3	-2.3	0.3
Soleus weight	1.5	4.4	10.0	0.8	-3.2	-1.1	2.4
Tibialis anterior weight	0.1	0.4	1.1	1.1	0.1	-0.5	-0.1
Tibia length	8.3	23.4	40.3	-6.3	-4.9	-1.0	5.3
Number of licking bursts	0.1	0.1	0.3	-0.2	-0.3	-0.4	0.5
Food consumed during 24 hour testing period	0.7	0.8	1.6	-0.3	0.0	-1.3	1.3
Times rat made contact with spout	1.6	1.8	4.9	0.5	-2.2	-0.2	1.4
Mean time between licks in bursts	1.0	1.4	2.3	0.3	1.4	1.1	-1.5
Mean num. licks in bursts	0.5	0.6	1.1	1.0	-1.0	-0.1	0.5
Std. dev. time between licks in bursts	1.2	1.5	4.2	1.0	-0.1	-2.0	0.9
Water consumed over 24 hours	0.2	0.2	0.5	0.2	-0.6	0.7	0.1
Indifference point 0 sec	1.0	1.7	4.1	2.0	-1.1	-0.8	0.9
Indifference point AUC	0.0	0.1	0.1	0.3	0.1	-0.2	0.2
Indifference point function ln k	0.8	1.2	1.9	1.4	1.1	0.2	-1.2
Indifference point function log k	0.8	1.2	1.9	1.4	1.1	0.2	-1.2
Delay discounting total patch changes 0 sec	1.3	2.2	5.8	2.4	-0.8	-1.1	0.9
Delay discounting total patch changes 12 sec	1.2	1.7	4.3	2.1	-1.4	-0.1	0.5
Delay discounting total patch changes 18 sec	0.9	1.2	3.4	1.8	0.2	-1.1	0.2
Delay discounting total patch changes 24 sec	1.3	1.7	2.7	0.3	-1.4	-1.4	1.6
Delay discounting total patch changes 6 sec	1.4	2.1	4.5	1.6	-2.1	-0.2	1.2
Delay discounting time to switch 0 sec	0.6	0.9	1.7	-0.3	0.5	1.3	-1.2
Delay discounting water rate 0 sec	2.8	4.4	8.9	0.6	-1.1	-3.0	2.7
Delay discounting water rate 12 sec	1.5	2.2	4.7	1.9	0.2	-2.2	0.7
Delay discounting water rate 18 sec	1.6	2.2	5.1	1.1	-0.2	-2.3	1.5
Delay discounting water rate 24 sec	4.7	6.4	14.7	2.2	-0.6	-3.8	2.4
Delay discounting water rate 6 sec	0.6	0.8	2.1	0.6	0.4	-1.5	0.7
Locomotor activity	0.4	0.6	1.7	0.2	1.3	0.5	-0.7
Locomotor testing distance	0.3	0.5	1.7	0.0	1.3	0.0	-0.4
Locomotor testing rearing	0.5	0.8	1.2	1.1	0.6	-1.1	0.5
Light reinforcement 1	2.0	3.6	4.9	1.7	-1.6	-2.2	2.1
Light reinforcement 2	1.9	2.5	4.1	-0.2	-1.9	-1.6	2.0
Reaction time number correct	2.9	4.1	9.8	2.2	0.8	-3.1	1.0
Reaction time mean minus median	0.5	0.7	1.2	-1.0	-0.6	1.1	-0.4
Reaction time mean minus median AUC	0.7	0.9	1.7	-1.3	-1.2	0.6	0.4
Reaction time num false alarms	0.3	0.4	0.9	0.9	0.1	0.6	-0.6
Reaction time num false alarms AUC	0.5	0.7	0.9	1.0	0.5	0.8	-0.9
Reaction time trials correct on left	2.9	4.1	9.8	2.2	0.8	-3.1	1.0
Reaction time trials on left	2.9	4.2	10.2	2.2	0.8	-3.2	1.0
Reaction time mean	0.2	0.3	0.8	-0.2	-0.3	-0.9	0.5
Reaction time mean AUC	0.3	0.4	1.1	-0.0	-0.2	-1.1	0.5
Median of all reaction times	0.3	0.5	1.5	0.0	-0.0	-1.2	0.6
Reaction time omissions	0.5	0.7	1.4	-1.2	-0.7	-0.7	0.7
Reaction time false alarm rate	1.2	1.8	5.2	-0.2	0.1	2.3	-1.4
Reaction time premature initiation rate	1.3	1.7	3.6	1.9	0.7	0.8	-1.5
Reaction time premature initiations	2.0	2.9	8.5	2.9	1.1	-1.1	-0.8
Std. dev. reaction times	0.1	0.2	0.5	-0.2	0.4	0.3	-0.7
Reaction time trials completed	2.9	4.2	10.2	2.2	0.8	-3.2	1.0
Reaction time trials AUC	3.1	4.5	10.5	2.4	0.7	-3.2	1.1
Social response proportion	0.1	0.1	0.1	0.4	0.3	-0.4	-0.3
Social responses	0.1	0.1	0.3	-0.1	-0.2	-0.5	0.5
Social time	0.1	0.2	0.4	0.5	0.3	-0.6	-0.1
Conditioned locomotion	3.2	3.8	6.5	0.4	-1.6	-2.5	2.5
Cocaine response after cond. corrected	0.1	0.1	0.4	-0.2	0.6	0.2	-0.3
Cocaine response after cond. not corrected	0.7	0.8	1.2	-0.5	1.1	0.8	-1.0
Cocaine response before conditioning	0.8	1.0	1.4	-0.8	1.2	0.8	-1.1
Saline control response	2.0	2.7	4.6	-0.7	-2.0	-1.2	2.1
Condit. Reinf. active minus inactive responses	0.9	1.1	1.7	-1.0	-1.1	-0.9	1.3
Condit. Reinf. active-inactive response ratio	2.3	2.4	5.8	-0.7	-2.4	-0.5	1.8
Condit. Reinf. active responses	0.4	0.5	1.4	0.2	-0.3	-1.2	0.7
Condit. Reinf. inactive responses	0.8	1.0	2.0	1.0	1.4	-0.6	-0.8
Condit. Reinf. lever presses	1.2	1.6	3.4	1.6	-0.0	-1.8	0.7
Condit. Reinf. lever reinforcers received	0.7	1.0	3.0	0.7	-0.0	-1.7	0.6
Pavlov. Cond. lever latency	1.9	2.6	5.0	-1.8	0.7	2.2	-1.2
Pavlov. Cond. magazine entry latency	1.8	2.1	3.8	1.6	2.0	-0.9	-1.0
Pavlov. Cond. change in total contacts	1.3	1.8	3.9	2.0	0.9	-1.6	-0.2
Pavlov. Cond. index score	1.3	1.7	3.0	1.7	0.8	-1.7	0.1
Pavlov. Cond. latency score	1.3	1.6	3.3	1.5	0.8	-1.8	0.2
Pavlov. Cond. lever contacts	2.0	2.8	5.9	1.7	-0.8	-2.4	1.4
Pavlov. Cond. magazine entry number	1.7	2.1	3.3	-1.8	-1.7	1.3	0.8
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.6	-0.6	-1.4	-0.9	1.6
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	3.2	1.8	1.0	-1.7	-0.1
Pavlov. Cond. response bias	1.3	1.8	3.9	1.8	-0.0	-2.0	0.5
Conditioned reinforcement - actives	0.4	0.4	0.6	0.5	-0.5	-0.8	0.7
Conditioned reinforcement - inactives	0.9	1.0	2.3	-0.6	-0.7	-0.9	1.5
Conditioned locomotion	0.7	0.9	1.5	0.7	-1.2	-0.5	1.1
Intermittent access intake day 1-15 change	0.4	0.4	0.9	-1.0	0.5	-0.3	0.4
Intermittent access intake escalation	0.3	0.3	0.6	-0.8	0.3	-0.5	0.5
Intermittent access intake escalation 2	0.4	0.4	0.6	-0.8	-0.6	-0.4	0.8
Intermitt. access day 1 inactive lever presses	1.5	1.6	2.7	-1.2	-1.1	-1.0	1.6
Intermitt. access day 15 inactive lever presses	1.5	1.7	3.3	0.1	-0.9	-1.8	1.7
Intermitt. access escalation Index	1.5	1.3	2.2	-0.3	-1.5	-1.1	1.4
Intermittent access day 1 total infusions	0.2	0.2	0.4	0.5	-0.4	-0.4	0.6
Intermittent access day 15 total infusions	0.4	0.4	1.0	-0.4	-0.4	-0.6	1.0
Intermittent access terminal intake (last 3 days)	0.6	0.6	1.3	-0.5	-0.7	-0.7	1.1
Intermittent access total infusions	0.3	0.4	0.9	0.0	-0.5	-0.6	0.9
Intermittent access day 1 locomotion	0.7	0.7	1.1	0.7	-1.0	-0.7	0.9
Intermittent access day 15 total locomotion	0.3	0.3	0.5	-0.4	-0.7	-0.1	0.7
Intermittent access total locomotion	0.6	0.6	1.1	0.2	-1.1	-0.6	1.0
Intermittent access standard deviation	1.3	1.4	3.4	-1.9	1.1	0.9	-0.4
Cocaine induced anxiety	4.2	4.9	9.0	-1.6	-3.0	-1.3	2.5
Post-drug Anxiety	0.6	0.7	1.1	-0.7	-1.0	-0.9	0.7
Baseline Anxiety	5.6	5.9	10.3	0.7	3.2	1.7	-3.1
Lifetime Intake	0.1	0.1	0.3	-0.1	-0.3	-0.2	0.5
Incentive Sensitization - Responses	0.0	0.0	0.2	-0.4	0.1	0.0	-0.0
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.5	0.2	0.1	-0.1
Progressive ratio test 1 active lever presses	0.7	0.7	1.7	0.1	-0.8	-0.8	1.3
Progressive ratio test 1 breakpoint	0.8	0.9	1.9	0.2	-0.8	-0.9	1.4
Progressive ratio test 1 inactive lever presses	2.7	2.9	5.4	-0.7	-1.5	-1.8	2.3
Progressive ratio test 2 active lever presses	0.3	0.3	0.6	-0.2	-0.7	-0.3	0.7
Progressive ratio test 2 breakpoint	0.3	0.3	0.7	-0.2	-0.3	-0.6	0.8
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.5	-0.7	-0.1	-0.4	0.7
Total sessions with >9 infusions	0.4	0.5	0.8	-0.6	0.9	0.6	-0.6
Short access day 1 total inactive lever presses	0.2	0.2	0.5	-0.4	-0.3	-0.0	0.7
Short access day 10 total inactive lever presses	2.3	2.5	4.1	-1.0	-1.5	-1.6	2.0
Short access day 1 total infusions	0.9	1.0	1.5	0.0	1.2	1.0	-1.2
Short access day 10 total infusions	0.5	0.5	1.2	-0.3	-0.7	-0.5	1.1
Short access total infusions	0.0	0.0	0.0	0.1	0.1	0.2	0.0
Short access day 1 locomotion	0.4	0.4	1.1	-0.5	0.2	1.1	-0.4
Short access day 10 total locomotion	0.3	0.3	0.9	-0.3	0.1	1.0	-0.6
Short access total locomotion	0.7	0.7	1.8	-0.6	0.2	1.3	-0.8
Compulsive drug intake	0.7	0.7	1.1	0.4	-1.1	-1.0	0.7
One hour access (0.3 mA shock)	1.0	1.2	1.9	0.4	-1.0	-1.4	1.4
One hour access (shock baseline)	0.1	0.2	0.5	-0.1	-0.4	-0.2	0.7
Number of responses in last shaping day	1.4	1.4	1.8	-1.2	-1.4	-0.8	1.3
Context. condit. distance diff. score	1.1	1.3	4.3	-0.1	0.6	-2.1	0.7
Locomotion velocity, session 1	3.2	3.5	6.3	-1.1	1.3	2.5	-2.1
Locomotion distance, session 1	1.6	2.1	2.9	1.6	1.7	0.5	-1.7
Locomotion velocity, session 2	3.5	4.1	7.4	1.0	1.5	2.3	-2.7
Locomotion distance, session 2	1.2	1.7	6.6	2.6	-0.0	-0.3	-0.5
Locomotion velocity, session 3	1.6	1.9	3.1	-0.5	1.2	1.8	-1.7
Locomotion distance, session 3	2.4	2.6	5.3	0.6	1.8	1.3	-2.3
Stereotopy head waving bouts, day 3	0.5	0.6	1.4	-0.7	0.5	1.2	-0.7
Stereotopy head waving duration, day 3	0.3	0.4	0.6	-0.7	0.8	0.6	-0.5
Locomotion velocity, session 7	1.1	1.2	3.7	-0.1	1.9	0.2	-1.0
Locomotion distance, session 7	3.4	4.4	10.8	1.6	3.3	-0.4	-2.0
Stereotopy head waving bouts, day 7	0.4	0.4	0.9	-1.0	-0.5	-0.6	0.5
Stereotopy head waving duration, day 7	0.9	1.1	2.7	-1.6	-1.0	-0.2	0.9
Locomotion velocity, session 8	1.6	1.9	6.1	-0.9	2.5	-0.7	-0.6
Locomotion distance, session 8	1.9	2.9	6.2	2.1	0.6	-2.5	0.5
Degree of sensitization distance	1.2	1.2	2.8	1.1	0.1	-1.7	1.0
Degree of sensitization stereotypy	0.6	0.7	1.0	-0.5	-0.7	-1.0	0.9
Condit. Reinf. active minus inactive responses	2.0	2.2	3.6	0.4	-1.7	-1.5	1.9
Condit. Reinf. active-inactive response ratio	0.9	1.0	1.8	0.3	-0.7	-1.4	1.2
Condit. Reinf. active responses	3.6	4.4	6.9	0.6	-2.6	-1.8	2.6
Condit. Reinf. inactive responses	1.2	1.4	2.6	0.8	-1.6	-0.8	1.3
Incentive salience index mean	1.9	2.3	3.7	0.2	-1.9	-1.3	1.9
Condit. Reinf. lever presses	0.3	0.4	0.6	0.6	-0.7	-0.5	0.6
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.7	0.3	-0.1	-0.3
Time in novel zone, hab. session 1	0.5	0.5	1.7	-1.3	0.6	-0.1	0.1
Total zone transitions, hab. session 1	0.6	0.8	2.7	1.6	0.4	-0.4	-0.5
Total locomotion distance, hab. session 1	0.8	1.1	2.3	1.2	0.3	-1.5	0.8
Locomotion velocity, hab. session 1	0.9	1.3	2.5	1.6	-0.2	-1.4	0.9
Time in familiar zone, hab. session 2	0.4	0.4	0.9	0.5	1.0	-0.4	-0.4
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.5	0.0	0.5	-0.3
Total zone transitions, hab. session 2	1.9	2.5	8.6	2.9	-0.2	-1.2	-0.2
Total locomotion distance, hab. session 2	2.6	3.5	7.7	2.8	-1.3	-1.9	1.0
Locomotion velocity, hab. session 2	2.7	3.7	6.9	2.6	-1.6	-1.9	1.3
Novel to familiar place preference ratio	4.0	4.2	9.2	1.9	-3.0	-1.3	1.5
Novelty place preference	3.6	3.8	8.7	1.7	-3.0	-1.2	1.5
Time in novel zone, NPP test	3.4	3.5	7.4	1.8	-2.7	-1.2	1.4
Total zone transitions, NPP test	1.3	1.8	5.6	2.4	0.7	-1.1	-0.4
Total locomotion distance, NPP test	2.7	3.8	10.7	3.3	-0.3	-2.0	0.6
Locomotion velocity, NPP test	2.4	3.5	9.3	3.0	-0.6	-1.9	0.8
Pavlov. Cond. lever latency	2.7	3.4	9.8	0.7	3.1	-1.5	-1.1
Pavlov. Cond. magazine entry latency	2.6	3.4	6.9	-1.7	-2.6	0.3	1.9
Pavlov. Cond. change in total contacts	1.0	1.0	2.8	1.0	-1.7	0.5	0.4
Pavlov. Cond. index score	3.9	4.9	12.9	-1.2	-3.6	0.2	2.3
Pavlov. Cond. latency score	3.6	4.6	12.1	-1.4	-3.5	0.7	2.0
Pavlov. Cond. lever contacts	2.2	2.6	8.5	0.1	-2.9	0.8	1.2
Pavlov. Cond. magazine entry number	2.4	3.0	6.3	1.7	2.5	-0.7	-1.5
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.5	1.6	-0.3	-1.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	3.9	4.9	13.0	-0.9	-3.6	-0.0	2.4
Pavlov. Cond. response bias	2.6	3.2	8.6	-1.0	-2.9	0.6	1.7
Bone: apparent density	0.3	0.5	1.4	1.2	-0.3	-0.8	0.2
Bone surface	0.1	0.2	0.8	-0.9	0.1	0.1	0.4
Bone volume	0.1	0.1	0.2	0.2	-0.1	-0.5	0.4
Bone: connectivity density	0.2	0.3	0.5	0.6	0.7	-0.5	-0.2
Bone: cortical apparent density	2.3	3.0	4.7	1.6	1.7	1.3	-2.2
Bone: cortical area	4.4	6.6	11.9	-1.8	-3.0	-1.4	3.4
Bone: cortical porosity	1.3	1.4	2.9	-1.1	-1.7	1.1	0.6
Bone: cortical porosity	1.1	1.2	2.0	-1.3	-1.4	0.5	0.9
Bone: cortical thickness	4.1	6.8	15.0	-0.9	-3.9	-0.9	3.2
Bone: cortical thickness	1.1	1.3	2.5	-0.8	-1.2	-0.7	1.6
Bone: cortical tissue density	2.6	3.4	5.4	1.6	1.9	1.4	-2.3
Bone: elastic displacement	1.8	2.0	4.4	1.0	-2.1	-0.7	1.5
Bone: elastic work	4.8	6.2	14.1	-0.4	-3.8	-0.8	3.2
Bone: endosteal estimation	0.3	0.7	1.9	-0.0	1.4	-0.9	-0.1
Bone: endosteal perimeter	0.7	1.5	4.5	-2.1	-0.2	-0.2	1.2
Bone: final force	3.4	5.6	10.6	-1.3	-2.6	-1.8	3.3
Bone: final moment	3.9	6.4	12.4	-1.1	-2.9	-1.9	3.5
Bone: marrow area	0.3	0.7	2.0	-0.1	1.4	-0.9	-0.1
Bone: maximum diameter	1.8	3.3	7.4	-2.7	-1.1	-0.4	2.1
Bone: maximum force	3.3	5.8	10.8	-1.1	-2.8	-1.8	3.3
Bone: maximum moment	3.8	6.6	12.5	-0.8	-3.1	-1.9	3.5
Bone: minimum diameter	2.4	4.4	8.8	-1.3	-2.3	-1.4	3.0
Bone: periosteal estimation	1.2	2.4	4.6	-1.3	-1.1	-1.4	2.1
Bone: periosteal perimeter	2.8	4.7	8.6	-2.9	-2.1	0.2	2.4
Bone: post-yield work	0.3	0.4	1.2	1.1	0.3	-0.5	0.1
Bone: stiffness	0.5	0.8	1.8	-1.3	-0.4	-0.5	0.9
Bone: tissue strength	2.7	2.6	3.5	1.6	-1.9	-1.5	1.5
Bone: trabecular number	0.0	0.1	0.1	0.4	0.0	0.0	-0.3
Bone: trabecular spacing	1.5	1.9	6.4	0.1	0.5	-2.5	1.0
Bone: trabecular thickness	0.7	0.9	2.1	0.5	-1.4	1.0	0.2
Bone: trabecular tissue density	0.8	1.1	1.4	-0.7	1.1	1.2	-1.1
Breakpoint value in progressive ratio session	0.5	0.6	0.7	0.8	-0.8	-0.8	0.8
Distance traveled before self-admin	0.8	0.8	1.9	-1.4	-0.5	-0.4	1.0
Distance traveled after self-admin	1.2	1.3	2.4	1.3	0.1	-1.5	1.0
Delta time in closed arm before/after self-admin	0.4	0.4	0.7	-0.8	-0.8	0.5	0.3
Delta time in open arm before/after self-admin	0.6	0.6	1.2	1.0	0.0	-1.1	0.5
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.0	-0.3	0.2	-0.1
Extinction: sum of active levers before priming	1.0	1.0	2.0	0.7	1.4	0.6	-1.1
Active lever presses in extinction session 6	0.1	0.1	0.1	0.2	-0.3	-0.2	0.4
Delta distance traveled before/after self-admin	1.3	1.4	3.9	2.0	0.6	-1.1	0.1
Delta ambulatory time before/after self-admin	1.4	1.5	4.3	2.1	1.0	-0.6	-0.5
Time in closed arm before self-admin	0.7	0.8	1.6	-0.2	0.8	1.0	-1.2
Time in closed arm after self-admin	1.8	1.9	4.5	-1.0	0.1	2.1	-1.5
Time in open arm before self-admin	0.2	0.2	0.5	-0.7	-0.3	0.3	0.1
Time in open arm after self-admin	0.2	0.2	0.4	0.6	0.4	-0.6	0.2
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	0.5	-0.1	-0.8	0.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.4	-0.5	-0.3	0.3
Time to tail flick, vehicle, after self-admin	1.7	1.8	2.9	-0.1	1.2	1.7	-1.7
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.2
Time to tail flick, test, after self-admin	0.3	0.3	1.1	-1.0	0.1	0.3	-0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.4	0.6	0.4	0.0	-0.2
Delta time to tail flick, test, before/after SA	0.6	0.6	1.1	-0.8	1.1	0.4	-0.5
Ambulatory time before self-admin	1.7	1.8	2.7	-1.7	-1.1	-0.9	1.5
Ambulatory time after self-admin	0.7	0.8	1.9	0.7	-0.1	-1.4	1.0
Total heroin consumption	0.3	0.4	1.3	-1.1	-0.2	-0.1	0.3
Area under the delay curve	2.0	2.1	2.8	-1.7	1.5	1.0	-1.6
Delay disc. indifference point, 0s delay	0.7	0.8	3.2	-1.8	0.3	-0.0	-0.0
Delay disc. indifference point, 16s delay	1.4	1.4	3.5	0.5	1.9	-0.1	-1.4
Delay disc. indifference point, 2s delay	0.9	1.0	2.9	-1.7	0.3	0.7	-0.6
Delay disc. indifference point, 24s delay	3.5	3.4	7.2	0.1	1.5	2.0	-2.7
Delay disc. indifference point, 4s delay	1.2	1.3	3.8	-2.0	0.7	0.7	-0.5
Delay disc. indifference point, 8s delay	2.9	3.0	7.4	-2.7	1.0	1.3	-1.4
Delay discount exponential model param	2.6	2.8	3.5	1.8	-1.6	-1.3	1.9
Delay discount hyperbolic model param	2.5	2.6	3.3	1.8	-1.6	-1.3	1.7
Fecal boli incidents, locomotor time 1	0.5	0.6	1.6	1.3	0.3	0.3	-0.7
Change in fecal boli incidents, locomotor task	3.0	2.9	4.9	0.4	1.7	1.9	-2.2
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.5	-0.0	1.2	-0.9	-0.0
Bouts of movement, locomotor time 1	1.3	1.4	2.8	0.6	1.1	1.1	-1.7
Total resting periods, locomotor time 1	1.7	1.9	3.6	0.8	1.1	1.5	-1.9
Rest time, locomotor task time 1	0.3	0.4	1.2	0.1	-0.4	1.1	-0.4
Distance moved, locomotor task time 1	0.4	0.5	0.8	-0.2	-0.6	-0.9	0.9
Vertical activity count, locomotor time 1	1.1	1.2	3.3	0.3	-0.5	-1.8	1.1
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.9	0.3	-0.9	0.7	0.1
Bouts of movement, locomotor time 2	1.2	1.3	2.7	0.1	1.5	0.6	-1.7
Total resting periods, locomotor time 2	0.8	0.9	1.8	0.1	1.2	0.4	-1.3
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.3	0.0	0.5	-0.5
Distance moved, locomotor task time 2	0.3	0.4	0.7	-0.4	-0.9	0.1	0.7
Vertical activity count, locomotor time 2	0.3	0.3	0.7	0.0	-0.1	-0.8	0.8
Weight adjusted by age	2.3	2.6	4.4	-0.5	-2.1	-1.2	2.1
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	2.0	-0.6	-1.4	-0.5	1.3
Locomotion in novel chamber	0.1	0.1	0.2	0.4	0.1	-0.4	0.2
Locomotion in novel chamber post-restriction	0.5	0.5	0.9	0.4	-1.0	-0.5	0.9
Progressive ratio	0.4	0.4	1.3	1.1	-0.2	0.1	-0.6
Food seeking constrained by brief footshock	0.0	0.0	0.0	-0.1	0.1	0.1	-0.2
Seeking ratio, punishment vs. effort	0.4	0.4	1.0	-1.0	0.6	-0.4	0.5
Run reversals in cocaine runway, females	1.0	1.0	2.6	0.9	1.6	-0.3	-0.7
Run reversals in cocaine runway, males	0.7	0.7	2.0	-0.2	-1.4	0.2	0.8
Latency to leave start box in cocaine runway	0.5	0.6	1.1	1.0	0.8	0.3	-0.8
Latency to leave start box in cocaine runway, F	0.3	0.4	1.0	1.0	0.6	-0.2	-0.3
Latency to leave start box in cocaine runway, M	0.4	0.4	1.4	1.2	0.1	0.2	-0.4
Cd content in liver	1.6	1.7	3.9	1.2	2.0	-0.2	-1.3
Co content in liver	0.4	0.4	1.1	1.0	0.5	-0.6	-0.1
Cu content in liver	0.2	0.3	0.7	-0.2	-0.8	0.5	0.3
Fe content in liver	0.7	0.8	1.9	0.4	1.4	0.4	-1.0
K content in liver	1.5	1.5	3.1	0.1	-1.2	-1.2	1.7
Mg content in liver	1.0	1.0	2.5	1.6	-0.2	-1.1	0.5
Mn content in liver	0.5	0.6	2.1	-1.5	-0.1	0.1	0.5
Na content in liver	0.2	0.2	0.5	-0.7	-0.3	0.4	0.2
Rb content in liver	1.4	1.7	3.0	1.3	-0.9	-1.7	1.2
Se content in liver	0.2	0.3	0.8	-0.2	0.2	-0.9	0.5
Sr content in liver	0.6	0.5	1.7	-0.0	-0.6	1.3	-0.3
Zn content in liver	0.6	0.7	1.7	-0.7	-0.7	1.3	-0.0