Hub : Genes

Lyzl6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression ENSRNOG00000003501 0.31 0.11 4.1e-11 0.17 0.17 0.16 0.17 2.4e-09 1.2e-09 5.2e-09 2.1e-09
2 Brain gene expression ENSRNOG00000003501 0.19 0.05 0.0e+00 0.22 0.23 0.23 0.24 1.1e-20 2.5e-21 6.5e-21 1.1e-21
3 PL gene expression ENSRNOG00000003501 0.35 0.1 0.0e+00 0.31 0.3 0.31 0.31 4.8e-24 2.9e-23 6.5e-24 2.3e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail0.31.01.70.31.11.3
BMI without tail0.00.10.1-0.3-0.3-0.2
Body weight0.41.92.6-1.6-1.3-1.2
Epididymis fat weight0.10.20.3-0.5-0.4-0.5
Glucose1.01.51.81.01.31.3
Heart weight0.30.40.9-0.9-0.4-0.3
Left kidney weight0.10.10.3-0.6-0.0-0.4
Right kidney weight0.00.00.10.20.30.1
Tail length0.61.82.3-1.0-1.4-1.5
Length with tail1.14.04.8-1.7-2.0-2.2
Length without tail0.51.21.3-1.0-1.1-1.1
Liver weight, left0.30.40.7-0.2-0.7-0.8
Liver weight, right0.71.22.11.41.00.7
Parametrial fat weight0.71.31.9-0.6-1.3-1.4
Retroperitoneal fat weight0.20.81.2-0.6-1.0-1.1
Intraocular pressure0.10.10.2-0.4-0.10.1
Extensor digitorum longus weight2.39.012.51.83.43.5
Soleus weight0.00.10.4-0.60.1-0.0
Tibialis anterior weight0.00.20.3-0.50.10.5
Tibia length0.20.71.31.10.70.6
Number of licking bursts0.50.61.00.20.81.0
Food consumed during 24 hour testing period0.20.30.6-0.8-0.1-0.4
Times rat made contact with spout0.00.00.10.10.30.1
Mean time between licks in bursts0.60.81.30.41.01.1
Mean num. licks in bursts0.30.30.7-0.1-0.6-0.8
Std. dev. time between licks in bursts0.10.10.2-0.00.30.4
Water consumed over 24 hours0.60.70.90.80.90.7
Indifference point 0 sec1.01.62.5-0.6-1.6-1.4
Indifference point AUC0.40.50.7-0.9-0.7-0.4
Indifference point function ln k0.50.61.2-0.3-0.8-1.1
Indifference point function log k0.50.61.2-0.3-0.8-1.1
Delay discounting total patch changes 0 sec1.52.43.5-0.9-1.9-1.7
Delay discounting total patch changes 12 sec1.62.13.4-1.2-1.8-1.3
Delay discounting total patch changes 18 sec0.60.80.9-0.9-0.9-0.9
Delay discounting total patch changes 24 sec1.21.52.3-0.7-1.5-1.3
Delay discounting total patch changes 6 sec0.40.71.2-0.6-1.1-0.7
Delay discounting time to switch 0 sec0.00.00.1-0.20.10.2
Delay discounting water rate 0 sec0.00.10.10.1-0.2-0.4
Delay discounting water rate 12 sec0.50.70.90.91.00.8
Delay discounting water rate 18 sec0.40.61.41.20.40.4
Delay discounting water rate 24 sec0.50.71.11.10.80.6
Delay discounting water rate 6 sec0.40.61.0-0.4-0.8-1.0
Locomotor activity2.33.64.4-1.9-2.1-1.7
Locomotor testing distance4.88.09.0-2.8-3.0-2.7
Locomotor testing rearing2.33.64.6-2.2-1.9-1.5
Light reinforcement 10.61.21.8-0.6-1.3-1.2
Light reinforcement 20.91.21.8-0.4-1.3-1.3
Reaction time number correct0.00.00.1-0.00.30.1
Reaction time mean minus median0.20.20.3-0.5-0.4-0.5
Reaction time mean minus median AUC0.00.00.10.1-0.1-0.2
Reaction time num false alarms1.21.71.9-1.4-1.3-1.2
Reaction time num false alarms AUC1.62.32.4-1.5-1.6-1.5
Reaction time trials correct on left0.00.00.1-0.00.30.1
Reaction time trials on left0.00.00.0-0.10.20.0
Reaction time mean0.10.10.2-0.0-0.4-0.4
Reaction time mean AUC0.00.00.00.2-0.2-0.2
Median of all reaction times0.10.20.3-0.1-0.5-0.5
Reaction time omissions3.04.15.5-1.6-2.1-2.4
Reaction time false alarm rate1.31.82.0-1.3-1.4-1.3
Reaction time premature initiation rate1.21.72.0-1.2-1.4-1.2
Reaction time premature initiations1.11.61.8-1.2-1.3-1.2
Std. dev. reaction times0.10.10.10.1-0.3-0.4
Reaction time trials completed0.00.00.0-0.10.20.0
Reaction time trials AUC0.00.00.0-0.10.20.1
Social response proportion0.10.10.4-0.6-0.0-0.1
Social responses0.40.50.5-0.7-0.7-0.7
Social time1.21.62.7-1.7-0.9-1.1
Conditioned locomotion0.10.10.10.40.20.3
Cocaine response after cond. corrected0.00.00.10.10.30.0
Cocaine response after cond. not corrected0.10.10.2-0.0-0.0-0.4
Cocaine response before conditioning0.30.30.7-0.2-0.6-0.8
Saline control response0.30.30.6-0.8-0.6-0.3
Condit. Reinf. active minus inactive responses5.16.37.0-2.3-2.6-2.6
Condit. Reinf. active-inactive response ratio5.15.35.6-2.3-2.2-2.4
Condit. Reinf. active responses5.37.48.2-2.5-2.8-2.9
Condit. Reinf. inactive responses0.81.01.4-0.6-1.2-1.1
Condit. Reinf. lever presses1.72.32.6-1.4-1.5-1.6
Condit. Reinf. lever reinforcers received4.36.06.8-2.2-2.5-2.6
Pavlov. Cond. lever latency0.30.40.60.60.60.8
Pavlov. Cond. magazine entry latency0.80.91.10.81.01.0
Pavlov. Cond. change in total contacts0.50.71.1-1.0-0.7-0.8
Pavlov. Cond. index score0.10.10.2-0.4-0.2-0.3
Pavlov. Cond. latency score0.10.20.3-0.5-0.3-0.4
Pavlov. Cond. lever contacts0.20.20.4-0.4-0.5-0.6
Pavlov. Cond. magazine entry number0.91.11.2-0.9-1.0-1.1
Pavlov. Cond. intertrial magazine entries6.88.89.1-2.9-3.0-3.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.3-0.1-0.2
Pavlov. Cond. response bias0.00.00.00.0-0.0-0.1
Conditioned reinforcement - actives0.30.30.5-0.7-0.5-0.2
Conditioned reinforcement - inactives1.61.82.2-1.2-1.5-1.4
Conditioned locomotion1.31.62.2-1.5-1.2-1.1
Intermittent access intake day 1-15 change0.30.30.3-0.5-0.5-0.5
Intermittent access intake escalation0.00.00.00.10.10.1
Intermittent access intake escalation 20.40.40.4-0.5-0.6-0.7
Intermitt. access day 1 inactive lever presses5.86.36.8-2.3-2.6-2.6
Intermitt. access day 15 inactive lever presses7.27.98.7-2.6-2.9-2.9
Intermitt. access escalation Index0.70.61.00.41.00.8
Intermittent access day 1 total infusions0.20.30.5-0.7-0.4-0.3
Intermittent access day 15 total infusions0.10.10.3-0.6-0.3-0.1
Intermittent access terminal intake (last 3 days)1.21.31.9-1.4-1.1-0.9
Intermittent access total infusions0.40.50.7-0.9-0.6-0.5
Intermittent access day 1 locomotion2.32.43.2-1.8-1.5-1.3
Intermittent access day 15 total locomotion1.01.01.2-1.1-1.1-0.8
Intermittent access total locomotion3.64.04.6-2.1-2.0-1.8
Intermittent access standard deviation2.02.22.9-1.2-1.7-1.5
Cocaine induced anxiety0.10.10.20.40.20.0
Post-drug Anxiety0.00.00.1-0.3-0.0-0.1
Baseline Anxiety0.00.00.1-0.30.10.1
Lifetime Intake1.31.41.7-1.3-1.2-1.1
Incentive Sensitization - Responses2.02.02.2-1.5-1.4-1.3
Incentive Sensitization - Breakpoint1.81.81.9-1.4-1.4-1.2
Progressive ratio test 1 active lever presses1.81.92.2-1.5-1.4-1.2
Progressive ratio test 1 breakpoint2.62.63.2-1.8-1.6-1.5
Progressive ratio test 1 inactive lever presses4.85.26.2-2.0-2.5-2.3
Progressive ratio test 2 active lever presses1.61.72.0-1.3-1.4-1.2
Progressive ratio test 2 breakpoint1.71.92.2-1.4-1.5-1.3
Progressive ratio test 2 inactive lever presses3.23.74.3-1.8-2.1-1.9
Total sessions with >9 infusions0.30.30.4-0.6-0.5-0.5
Short access day 1 total inactive lever presses0.91.01.2-1.1-0.9-1.0
Short access day 10 total inactive lever presses3.74.14.4-1.9-2.1-2.1
Short access day 1 total infusions1.31.41.5-1.2-1.1-1.1
Short access day 10 total infusions3.43.74.0-2.0-2.0-1.8
Short access total infusions3.03.33.4-1.8-1.8-1.8
Short access day 1 locomotion3.53.83.9-1.9-2.0-1.9
Short access day 10 total locomotion11.812.813.7-3.7-3.7-3.4
Short access total locomotion8.28.410.0-3.2-2.8-2.7
Compulsive drug intake1.81.82.11.41.31.3
One hour access (0.3 mA shock)0.20.20.4-0.6-0.4-0.2
One hour access (shock baseline)0.91.11.8-1.3-1.0-0.8
Number of responses in last shaping day3.53.64.4-2.1-1.7-1.8
Context. condit. distance diff. score1.31.61.91.11.41.3
Locomotion velocity, session 10.20.20.4-0.3-0.5-0.6
Locomotion distance, session 10.10.10.2-0.1-0.4-0.3
Locomotion velocity, session 20.10.10.20.4-0.1-0.1
Locomotion distance, session 20.10.10.3-0.2-0.6-0.3
Locomotion velocity, session 30.10.10.20.50.2-0.1
Locomotion distance, session 30.20.20.40.30.60.3
Stereotopy head waving bouts, day 30.50.61.51.20.40.4
Stereotopy head waving duration, day 30.50.61.21.10.40.6
Locomotion velocity, session 71.21.31.81.41.10.9
Locomotion distance, session 70.40.50.50.70.70.7
Stereotopy head waving bouts, day 70.40.51.01.00.60.3
Stereotopy head waving duration, day 71.72.03.11.71.31.1
Locomotion velocity, session 80.00.00.0-0.1-0.2-0.1
Locomotion distance, session 80.40.50.60.80.70.8
Degree of sensitization distance0.10.10.2-0.3-0.4-0.0
Degree of sensitization stereotypy0.80.91.11.11.00.6
Condit. Reinf. active minus inactive responses1.71.92.3-1.5-1.3-1.3
Condit. Reinf. active-inactive response ratio0.30.30.6-0.8-0.5-0.4
Condit. Reinf. active responses2.12.52.8-1.5-1.7-1.5
Condit. Reinf. inactive responses0.81.01.6-0.5-1.3-1.0
Incentive salience index mean1.82.22.3-1.5-1.4-1.5
Condit. Reinf. lever presses0.40.50.7-0.6-0.8-0.8
Time in familiar zone, hab. session 10.50.51.00.40.61.0
Time in novel zone, hab. session 10.10.10.30.0-0.1-0.6
Total zone transitions, hab. session 10.81.11.50.81.21.1
Total locomotion distance, hab. session 10.50.70.9-0.6-0.9-1.0
Locomotion velocity, hab. session 10.71.01.3-0.8-1.2-1.1
Time in familiar zone, hab. session 20.30.30.60.30.50.8
Time in novel zone, hab. session 20.20.20.50.0-0.3-0.7
Total zone transitions, hab. session 21.72.22.71.11.61.7
Total locomotion distance, hab. session 20.81.11.21.01.01.1
Locomotion velocity, hab. session 20.91.21.31.01.01.2
Novel to familiar place preference ratio1.11.11.5-1.0-1.2-0.9
Novelty place preference0.80.91.2-0.8-1.1-0.8
Time in novel zone, NPP test0.50.60.8-0.6-0.9-0.7
Total zone transitions, NPP test1.31.92.11.31.31.4
Total locomotion distance, NPP test0.00.10.20.4-0.00.1
Locomotion velocity, NPP test0.00.00.10.2-0.00.1
Pavlov. Cond. lever latency4.55.76.42.22.52.4
Pavlov. Cond. magazine entry latency5.06.48.0-1.9-2.8-2.7
Pavlov. Cond. change in total contacts3.53.84.3-1.7-2.0-2.1
Pavlov. Cond. index score5.06.47.7-2.1-2.8-2.6
Pavlov. Cond. latency score4.45.76.7-2.1-2.6-2.4
Pavlov. Cond. lever contacts3.84.54.7-2.1-2.2-2.1
Pavlov. Cond. magazine entry number4.05.16.61.62.62.5
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.5-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.5.46.87.8-2.2-2.8-2.7
Pavlov. Cond. response bias6.07.49.0-2.1-3.0-2.9
Bone: apparent density2.03.44.6-1.1-2.1-2.1
Bone surface6.311.112.9-2.9-3.5-3.6
Bone volume4.67.89.4-2.2-3.0-3.1
Bone: connectivity density3.14.86.2-1.6-2.4-2.5
Bone: cortical apparent density5.06.58.93.02.22.4
Bone: cortical area2.84.25.3-1.7-2.1-2.3
Bone: cortical porosity18.720.221.2-4.5-4.4-4.6
Bone: cortical porosity12.713.714.2-3.7-3.6-3.8
Bone: cortical thickness0.50.81.91.40.60.3
Bone: cortical thickness0.40.51.01.00.70.2
Bone: cortical tissue density4.86.28.42.92.22.4
Bone: elastic displacement0.00.10.10.3-0.0-0.3
Bone: elastic work1.41.82.5-1.0-1.4-1.6
Bone: endosteal estimation7.516.119.8-4.5-3.8-3.8
Bone: endosteal perimeter10.120.926.9-5.2-4.2-4.2
Bone: final force1.11.72.4-0.8-1.4-1.6
Bone: final moment1.22.02.9-0.9-1.5-1.7
Bone: marrow area7.415.919.5-4.4-3.8-3.8
Bone: maximum diameter4.68.58.6-2.9-2.9-2.9
Bone: maximum force2.23.84.3-1.7-2.1-2.0
Bone: maximum moment2.34.04.7-1.7-2.1-2.2
Bone: minimum diameter11.120.522.5-4.7-4.4-4.4
Bone: periosteal estimation7.515.415.7-4.0-3.9-4.0
Bone: periosteal perimeter6.611.012.9-3.6-3.1-3.2
Bone: post-yield work2.63.65.7-2.4-1.6-1.5
Bone: stiffness0.10.20.3-0.4-0.5-0.3
Bone: tissue strength1.01.01.41.20.61.0
Bone: trabecular number3.86.07.5-1.7-2.7-2.7
Bone: trabecular spacing1.21.62.40.81.31.5
Bone: trabecular thickness2.53.03.8-1.5-1.7-1.9
Bone: trabecular tissue density0.50.71.41.20.60.5
Breakpoint value in progressive ratio session0.91.01.3-1.1-1.0-0.9
Distance traveled before self-admin0.60.61.3-1.1-0.6-0.5
Distance traveled after self-admin0.10.10.2-0.40.10.2
Delta time in closed arm before/after self-admin1.11.11.21.11.01.0
Delta time in open arm before/after self-admin0.00.00.0-0.2-0.00.0
Diff in mean of infusions in LGA sessions0.50.60.9-0.9-0.8-0.6
Extinction: sum of active levers before priming0.00.00.0-0.1-0.10.0
Active lever presses in extinction session 63.43.34.3-2.1-1.8-1.5
Delta distance traveled before/after self-admin0.50.50.70.80.70.6
Delta ambulatory time before/after self-admin0.20.20.50.70.30.3
Time in closed arm before self-admin2.93.34.62.11.61.6
Time in closed arm after self-admin6.87.18.83.02.42.6
Time in open arm before self-admin0.20.20.3-0.40.50.5
Time in open arm after self-admin2.52.74.8-2.2-1.2-1.3
Sum of active levers in priming session hrs 5-60.20.20.30.20.50.5
Time to tail flick, vehicle, before self-admin1.11.11.21.11.01.0
Time to tail flick, vehicle, after self-admin0.70.71.1-0.6-1.0-0.9
Time to tail flick, test, before self-admin2.42.43.21.11.71.8
Time to tail flick, test, after self-admin0.10.10.2-0.4-0.3-0.3
Delta time to tail flick, vehicle, before/after SA3.53.54.3-1.5-2.1-1.9
Delta time to tail flick, test, before/after SA2.82.52.8-1.4-1.7-1.7
Ambulatory time before self-admin0.80.81.7-1.3-0.7-0.6
Ambulatory time after self-admin0.30.30.5-0.7-0.4-0.5
Total heroin consumption1.11.41.7-1.3-1.1-1.1
Area under the delay curve0.00.10.1-0.40.10.0
Delay disc. indifference point, 0s delay0.10.10.20.10.30.4
Delay disc. indifference point, 16s delay0.10.10.3-0.00.50.3
Delay disc. indifference point, 2s delay1.92.12.5-1.2-1.6-1.6
Delay disc. indifference point, 24s delay0.30.30.8-0.9-0.2-0.4
Delay disc. indifference point, 4s delay0.00.00.1-0.10.20.3
Delay disc. indifference point, 8s delay0.10.10.20.40.50.3
Delay discount exponential model param0.10.10.40.60.10.2
Delay discount hyperbolic model param0.10.20.30.60.30.3
Fecal boli incidents, locomotor time 10.00.10.10.10.30.2
Change in fecal boli incidents, locomotor task0.10.10.1-0.4-0.3-0.4
Time >=10cm from walls, locomotor time 11.01.01.30.81.11.0
Bouts of movement, locomotor time 11.51.72.01.31.31.4
Total resting periods, locomotor time 11.61.82.11.31.31.4
Rest time, locomotor task time 10.60.61.11.10.60.7
Distance moved, locomotor task time 10.60.71.2-1.1-0.7-0.6
Vertical activity count, locomotor time 10.40.40.7-0.9-0.5-0.6
Time >=10cm from walls, locomotor time 20.40.40.7-0.8-0.6-0.6
Bouts of movement, locomotor time 20.00.10.10.1-0.2-0.3
Total resting periods, locomotor time 20.10.10.30.50.30.1
Rest time, locomotor task time 21.11.31.71.01.31.1
Distance moved, locomotor task time 20.30.30.5-0.7-0.6-0.4
Vertical activity count, locomotor time 20.80.91.1-0.8-1.1-0.9
Weight adjusted by age0.10.20.5-0.7-0.0-0.2
Seeking ratio, delayed vs. immediate footshock0.70.81.7-1.3-0.7-0.4
Locomotion in novel chamber1.31.72.9-1.7-1.1-1.0
Locomotion in novel chamber post-restriction1.51.82.1-1.1-1.5-1.4
Progressive ratio0.10.10.1-0.3-0.3-0.1
Food seeking constrained by brief footshock0.50.60.8-0.9-0.8-0.5
Seeking ratio, punishment vs. effort0.10.10.1-0.3-0.2-0.2
Run reversals in cocaine runway, females0.10.10.2-0.00.40.3
Run reversals in cocaine runway, males1.21.21.2-1.1-1.1-1.1
Latency to leave start box in cocaine runway0.60.70.70.80.80.8
Latency to leave start box in cocaine runway, F1.01.11.30.91.11.2
Latency to leave start box in cocaine runway, M0.10.10.20.40.00.0
Cd content in liver4.24.65.71.92.12.4
Co content in liver0.10.20.2-0.20.40.5
Cu content in liver0.30.40.5-0.7-0.6-0.6
Fe content in liver5.66.78.12.82.62.3
K content in liver0.20.20.4-0.3-0.5-0.6
Mg content in liver0.80.91.21.10.90.7
Mn content in liver0.30.30.50.7-0.4-0.6
Na content in liver0.50.50.6-0.6-0.8-0.7
Rb content in liver1.01.21.51.01.01.2
Se content in liver3.44.14.81.72.12.2
Sr content in liver0.30.30.50.20.70.4
Zn content in liver0.00.00.00.10.0-0.0