Hub : Genes

Serpinf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000003233	0.19	0.1	4.4e-13	0.15	0.14	0.15	0.15	9.0e-14	4.0e-13	7.7e-14	7.8e-14
2	IL	gene expression	ENSRNOG00000003233	0.8	0.18	2.5e-06	0.24	0	0.23	0.21	2.1e-06	3.2e-01	3.8e-06	7.2e-06
3	Liver	gene expression	ENSRNOG00000003233	0.05	0.05	4.9e-04	0.03	0.02	0.02	0.02	4.7e-04	4.7e-03	4.6e-03	1.9e-03
4	Liver	mRNA stability	ENSRNOG00000003233	0.06	0.05	8.4e-05	0.04	0.03	0.02	0.03	2.0e-05	3.3e-04	1.2e-03	6.4e-04
5	OFC	gene expression	ENSRNOG00000003233	0.21	0.19	3.8e-03	0.07	0.05	0.08	0.08	7.7e-03	2.2e-02	6.8e-03	5.7e-03
6	PL	gene expression	ENSRNOG00000003233	0.31	0.12	0.0e+00	0.27	0.27	0.28	0.28	6.0e-21	2.2e-20	1.7e-21	2.3e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
BMI with tail	0.7	2.2	2.6	-1.5	-1.4	1.5	1.5	-1.5	-1.6
BMI without tail	0.1	0.2	0.6	0.2	-0.1	0.8	-0.1	-0.7	0.2
Body weight	0.2	0.7	2.3	0.7	1.5	0.7	-0.8	-0.5	-0.1
Epididymis fat weight	0.6	1.4	2.7	-0.7	-0.2	1.6	0.6	-1.6	-1.5
Glucose	1.8	2.8	6.3	1.0	1.0	-2.5	-0.9	2.4	1.3
Heart weight	0.2	0.2	0.4	0.4	0.7	-0.4	-0.5	0.5	0.3
Left kidney weight	5.1	14.6	16.4	3.6	3.9	-4.0	-3.6	4.0	3.8
Right kidney weight	4.7	13.5	15.5	3.5	3.9	-3.7	-3.6	3.8	3.6
Tail length	3.1	9.3	17.6	3.6	4.2	-1.1	-3.6	1.4	3.0
Length with tail	1.3	4.7	10.7	2.5	3.3	-0.8	-2.6	1.0	1.8
Length without tail	0.1	0.2	0.9	0.2	1.0	0.0	-0.4	-0.1	-0.4
Liver weight, left	1.9	3.1	5.3	2.2	2.3	-0.2	-2.3	0.4	1.7
Liver weight, right	0.8	1.3	2.3	1.4	1.5	0.4	-1.5	-0.2	1.1
Parametrial fat weight	1.0	2.0	5.8	0.0	0.5	2.4	-0.2	-2.3	-0.9
Retroperitoneal fat weight	0.1	0.2	0.7	0.2	0.8	-0.6	-0.3	0.5	-0.0
Intraocular pressure	1.7	2.4	3.8	-1.9	-1.8	0.4	1.9	-0.5	-1.7
Extensor digitorum longus weight	4.8	19.4	23.4	-4.3	-3.6	4.7	4.2	-4.8	-4.7
Soleus weight	0.6	1.7	4.2	0.0	1.2	2.1	-0.1	-1.9	-0.9
Tibialis anterior weight	5.7	19.6	26.9	-3.9	-3.2	5.1	3.9	-5.2	-5.0
Tibia length	1.9	5.4	7.8	2.8	2.7	-1.2	-2.8	1.4	2.6
Number of licking bursts	0.4	0.5	1.3	0.2	0.7	-1.1	-0.2	1.1	0.3
Food consumed during 24 hour testing period	0.2	0.3	0.7	-0.2	-0.4	0.8	0.2	-0.8	-0.2
Times rat made contact with spout	2.2	2.6	3.9	1.7	1.4	-1.3	-1.7	1.4	2.0
Mean time between licks in bursts	0.7	0.9	2.3	1.0	1.5	-0.6	-1.1	0.6	0.7
Mean num. licks in bursts	0.5	0.6	1.3	1.0	0.2	0.2	-1.0	-0.1	1.1
Std. dev. time between licks in bursts	0.2	0.3	0.5	-0.7	-0.1	0.4	0.6	-0.4	-0.7
Water consumed over 24 hours	1.4	1.6	2.3	1.5	1.5	-0.6	-1.5	0.8	1.4
Indifference point 0 sec	0.1	0.2	0.3	-0.5	-0.0	0.3	0.4	-0.4	-0.6
Indifference point AUC	0.3	0.4	0.8	-0.9	-0.5	0.1	0.9	-0.2	-0.6
Indifference point function ln k	0.3	0.5	1.1	-0.3	-0.6	1.0	0.2	-1.0	-0.6
Indifference point function log k	0.3	0.5	1.1	-0.3	-0.6	1.0	0.2	-1.0	-0.6
Delay discounting total patch changes 0 sec	0.2	0.3	0.6	-0.6	-0.2	0.3	0.5	-0.5	-0.7
Delay discounting total patch changes 12 sec	0.5	0.6	1.0	0.6	1.0	-0.9	-0.6	0.8	0.7
Delay discounting total patch changes 18 sec	1.2	1.6	2.8	0.8	1.3	-1.7	-0.8	1.6	0.9
Delay discounting total patch changes 24 sec	0.4	0.5	1.2	0.2	0.7	-1.1	-0.2	1.0	0.4
Delay discounting total patch changes 6 sec	0.2	0.3	0.5	-0.7	-0.3	-0.5	0.7	0.4	-0.7
Delay discounting time to switch 0 sec	2.8	4.3	5.3	2.1	2.3	-1.9	-2.1	2.0	2.1
Delay discounting water rate 0 sec	1.1	1.8	2.6	-1.5	-1.5	0.7	1.5	-0.8	-1.6
Delay discounting water rate 12 sec	0.0	0.0	0.2	0.0	-0.1	-0.0	-0.0	0.1	-0.4
Delay discounting water rate 18 sec	2.1	2.7	4.9	-1.5	-1.3	1.5	1.6	-1.6	-2.2
Delay discounting water rate 24 sec	0.4	0.6	1.0	-1.0	-0.8	0.2	1.0	-0.4	-0.9
Delay discounting water rate 6 sec	0.2	0.2	0.7	-0.5	-0.8	-0.3	0.4	0.2	-0.4
Locomotor activity	0.1	0.1	0.2	0.1	0.4	-0.4	-0.2	0.4	-0.4
Locomotor testing distance	0.1	0.1	0.3	-0.0	0.2	-0.5	-0.0	0.4	-0.6
Locomotor testing rearing	0.5	0.8	1.8	-1.0	-0.8	-0.2	1.0	-0.0	-1.4
Light reinforcement 1	0.2	0.4	1.2	-0.3	-0.2	-1.1	0.2	0.9	-0.5
Light reinforcement 2	3.4	4.5	8.3	1.6	1.6	-2.9	-1.7	2.8	1.7
Reaction time number correct	0.0	0.0	0.1	0.0	0.1	-0.1	-0.2	0.1	0.4
Reaction time mean minus median	0.3	0.4	0.7	-0.8	-0.7	0.3	0.7	-0.5	-0.8
Reaction time mean minus median AUC	2.0	2.6	3.6	-1.7	-1.4	1.4	1.6	-1.5	-1.9
Reaction time num false alarms	1.6	2.2	3.7	-1.9	-1.9	0.0	1.8	-0.3	-1.7
Reaction time num false alarms AUC	1.4	2.0	3.2	-1.8	-1.7	0.0	1.8	-0.3	-1.5
Reaction time trials correct on left	0.0	0.0	0.1	0.0	0.1	-0.1	-0.2	0.1	0.4
Reaction time trials on left	0.0	0.0	0.1	-0.0	0.0	-0.1	-0.1	0.0	0.3
Reaction time mean	0.0	0.1	0.1	0.1	-0.3	0.3	-0.2	-0.3	-0.1
Reaction time mean AUC	0.1	0.1	0.4	-0.1	-0.6	0.3	0.0	-0.3	-0.2
Median of all reaction times	0.1	0.1	0.3	0.5	-0.1	0.0	-0.5	0.1	0.3
Reaction time omissions	0.0	0.0	0.1	0.2	-0.2	0.1	-0.3	-0.2	0.1
Reaction time false alarm rate	1.2	1.8	2.9	-1.6	-1.5	0.2	1.7	-0.5	-1.6
Reaction time premature initiation rate	0.6	0.8	1.3	-0.7	-0.7	1.1	0.7	-1.1	-0.9
Reaction time premature initiations	0.5	0.8	1.1	-0.8	-0.8	1.0	0.7	-1.1	-0.8
Std. dev. reaction times	0.4	0.6	0.7	-0.7	-0.8	0.7	0.6	-0.8	-0.8
Reaction time trials completed	0.0	0.0	0.1	-0.0	0.0	-0.1	-0.1	0.0	0.3
Reaction time trials AUC	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.1	-0.0	0.4
Social response proportion	0.9	1.0	1.5	1.1	0.6	1.1	-1.2	-0.9	0.8
Social responses	0.1	0.2	0.5	0.2	0.2	0.7	-0.2	-0.7	-0.0
Social time	0.7	0.9	2.3	-0.3	-0.5	1.5	0.3	-1.5	-0.7
Conditioned locomotion	0.2	0.2	1.0	-0.3	-1.0	0.1	0.2	-0.1	0.3
Cocaine response after cond. corrected	0.3	0.3	0.5	0.7	0.1	0.7	-0.6	-0.6	0.5
Cocaine response after cond. not corrected	0.2	0.3	0.5	0.5	0.2	0.7	-0.5	-0.6	0.3
Cocaine response before conditioning	0.2	0.3	0.9	-0.6	0.1	0.2	0.5	-0.3	-0.9
Saline control response	0.5	0.7	1.5	-1.0	-0.7	-0.0	1.0	-0.1	-1.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.7	-0.2	0.4	0.6	-0.5	-0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.5	0.1	-0.2	-0.5	0.2	0.6
Condit. Reinf. active responses	1.0	1.3	2.5	-1.6	-0.7	0.3	1.5	-0.5	-1.6
Condit. Reinf. inactive responses	3.2	3.9	7.2	-2.7	-1.3	0.5	2.6	-0.8	-2.7
Condit. Reinf. lever presses	0.7	1.0	1.4	-1.2	-0.4	-1.1	1.2	0.9	-0.9
Condit. Reinf. lever reinforcers received	1.0	1.4	2.8	-1.7	-0.7	0.1	1.6	-0.3	-1.6
Pavlov. Cond. lever latency	0.8	1.1	3.1	-0.1	-0.7	1.8	0.1	-1.6	-0.3
Pavlov. Cond. magazine entry latency	2.6	3.0	5.1	1.3	1.8	-2.3	-1.4	2.2	1.0
Pavlov. Cond. change in total contacts	1.1	1.5	3.0	0.6	1.3	-1.7	-0.6	1.7	0.8
Pavlov. Cond. index score	1.6	2.0	5.5	0.4	1.2	-2.3	-0.4	2.2	0.5
Pavlov. Cond. latency score	1.6	2.1	5.7	0.3	1.1	-2.4	-0.3	2.2	0.5
Pavlov. Cond. lever contacts	1.0	1.4	3.4	0.5	1.2	-1.9	-0.5	1.8	0.5
Pavlov. Cond. magazine entry number	2.2	2.7	4.6	-1.2	-1.7	2.1	1.2	-2.1	-1.1
Pavlov. Cond. intertrial magazine entries	2.3	3.0	4.0	-1.5	-1.8	2.0	1.5	-2.0	-1.5
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	4.6	0.3	1.1	-2.2	-0.3	2.0	0.4
Pavlov. Cond. response bias	1.6	2.1	4.5	0.9	1.4	-2.1	-0.9	2.1	0.8
Conditioned reinforcement - actives	3.0	2.9	3.8	-1.6	-1.5	1.9	1.6	-2.0	-1.7
Conditioned reinforcement - inactives	1.1	1.2	1.4	-1.1	-0.9	1.2	1.0	-1.2	-1.2
Conditioned locomotion	0.1	0.1	0.5	-0.2	-0.0	-0.7	0.2	0.6	0.1
Intermittent access intake day 1-15 change	2.0	2.0	3.4	-1.8	-1.7	0.3	1.8	-0.6	-1.4
Intermittent access intake escalation	0.9	0.9	1.6	-1.2	-1.1	-0.6	1.3	0.2	-0.9
Intermittent access intake escalation 2	0.7	0.7	1.0	-0.9	-0.9	-1.0	0.9	0.7	-0.6
Intermitt. access day 1 inactive lever presses	1.0	1.0	2.3	0.5	0.7	-1.4	-0.6	1.5	1.0
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	-0.2	-0.2	-0.5	0.2	0.5	-0.1
Intermitt. access escalation Index	3.2	2.9	5.2	2.3	2.1	0.1	-2.3	0.1	1.7
Intermittent access day 1 total infusions	0.4	0.4	0.6	-0.7	-0.5	0.6	0.7	-0.6	-0.8
Intermittent access day 15 total infusions	2.3	2.6	4.1	-1.9	-1.8	0.7	2.0	-0.9	-1.8
Intermittent access terminal intake (last 3 days)	2.0	2.2	3.1	-1.5	-1.4	1.2	1.6	-1.3	-1.7
Intermittent access total infusions	1.1	1.3	2.0	-1.3	-1.2	0.6	1.4	-0.7	-1.3
Intermittent access day 1 locomotion	0.6	0.6	0.8	0.6	0.9	-0.7	-0.6	0.9	0.8
Intermittent access day 15 total locomotion	0.2	0.3	0.4	-0.6	-0.3	-0.6	0.6	0.5	-0.3
Intermittent access total locomotion	0.0	0.0	0.1	-0.2	0.1	-0.3	0.2	0.3	-0.0
Intermittent access standard deviation	3.3	3.5	5.9	-2.4	-2.3	0.5	2.4	-0.6	-1.9
Cocaine induced anxiety	0.9	1.1	1.6	-1.2	-1.3	0.7	1.2	-0.7	-1.0
Post-drug Anxiety	0.5	0.6	0.7	-0.8	-0.8	0.7	0.8	-0.8	-0.8
Baseline Anxiety	0.2	0.2	0.4	0.5	0.6	-0.2	-0.6	0.2	0.4
Lifetime Intake	1.3	1.5	2.4	-1.4	-1.3	0.7	1.5	-0.8	-1.3
Incentive Sensitization - Responses	0.4	0.4	0.7	-0.8	-0.6	0.4	0.8	-0.5	-0.6
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	-0.7	-0.5	0.3	0.7	-0.4	-0.5
Progressive ratio test 1 active lever presses	0.3	0.3	0.4	-0.5	-0.5	0.5	0.6	-0.5	-0.5
Progressive ratio test 1 breakpoint	0.5	0.5	0.6	-0.7	-0.6	0.8	0.8	-0.7	-0.7
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.1	0.2	0.2
Progressive ratio test 2 active lever presses	0.9	1.0	1.6	-1.2	-1.1	0.6	1.3	-0.7	-1.0
Progressive ratio test 2 breakpoint	1.0	1.1	1.8	-1.2	-1.1	0.6	1.3	-0.8	-1.0
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.4	-1.2	-1.1	0.3	1.2	-0.4	-0.9
Total sessions with >9 infusions	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4	-0.4	-0.2
Short access day 1 total inactive lever presses	0.1	0.1	0.3	-0.1	-0.0	0.6	0.1	-0.5	-0.1
Short access day 10 total inactive lever presses	0.5	0.6	1.0	0.9	0.8	-0.1	-1.0	0.3	0.9
Short access day 1 total infusions	1.1	1.2	2.1	-1.4	-1.4	0.4	1.5	-0.5	-1.0
Short access day 10 total infusions	1.4	1.5	2.0	-1.4	-1.2	0.9	1.4	-1.0	-1.3
Short access total infusions	1.6	1.7	2.8	-1.6	-1.5	0.7	1.7	-0.8	-1.3
Short access day 1 locomotion	0.2	0.2	0.4	-0.5	-0.6	-0.3	0.6	0.2	-0.3
Short access day 10 total locomotion	0.2	0.2	0.4	0.2	0.4	-0.4	-0.3	0.5	0.6
Short access total locomotion	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.4	0.2	-0.1
Compulsive drug intake	0.9	0.9	1.3	1.2	1.0	-0.1	-1.2	0.3	1.1
One hour access (0.3 mA shock)	2.6	3.0	4.4	-1.9	-2.1	1.1	2.0	-1.3	-1.8
One hour access (shock baseline)	2.1	2.5	3.5	-1.9	-1.9	0.7	1.9	-0.9	-1.8
Number of responses in last shaping day	0.3	0.3	0.9	-0.1	-0.1	-1.0	0.2	0.9	0.3
Context. condit. distance diff. score	1.0	1.2	3.1	-0.3	-0.5	1.8	0.3	-1.7	-0.8
Locomotion velocity, session 1	0.8	0.9	2.7	-0.1	-0.1	1.7	0.0	-1.6	-0.5
Locomotion distance, session 1	0.4	0.6	1.0	-0.9	-0.7	0.4	0.9	-0.5	-1.0
Locomotion velocity, session 2	0.4	0.4	0.8	-0.5	-0.2	0.9	0.5	-0.9	-0.7
Locomotion distance, session 2	1.0	1.4	2.1	-1.2	-1.0	1.2	1.2	-1.2	-1.5
Locomotion velocity, session 3	4.1	4.7	7.8	1.6	1.7	-2.8	-1.6	2.8	2.2
Locomotion distance, session 3	0.1	0.1	0.3	-0.5	-0.4	-0.1	0.5	0.0	-0.3
Stereotopy head waving bouts, day 3	0.6	0.7	2.2	0.6	1.5	-0.4	-0.6	0.5	0.9
Stereotopy head waving duration, day 3	0.4	0.5	1.3	-0.2	0.9	-1.1	0.2	1.0	0.2
Locomotion velocity, session 7	1.3	1.4	2.1	-1.1	-1.1	1.4	1.1	-1.4	-1.0
Locomotion distance, session 7	1.8	2.3	3.5	-1.3	-1.2	1.9	1.2	-1.9	-1.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	-0.5	0.6	0.3	0.5	-0.3	-0.5
Stereotopy head waving duration, day 7	0.3	0.3	0.5	-0.7	0.5	0.3	0.7	-0.3	-0.7
Locomotion velocity, session 8	0.5	0.6	0.9	-0.8	-0.6	0.7	0.8	-0.7	-0.9
Locomotion distance, session 8	0.6	0.9	2.0	-0.5	-0.2	1.4	0.4	-1.4	-1.0
Degree of sensitization distance	0.6	0.6	1.7	-0.1	-0.2	1.3	0.0	-1.2	-0.5
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.3	0.4	0.6	0.2	-0.6	-0.4
Condit. Reinf. active minus inactive responses	0.4	0.4	1.1	0.7	0.5	-0.3	-0.7	0.4	1.0
Condit. Reinf. active-inactive response ratio	4.0	4.3	6.9	2.2	2.1	-1.5	-2.2	1.6	2.6
Condit. Reinf. active responses	0.4	0.5	0.9	-0.5	-0.8	1.0	0.5	-0.9	-0.3
Condit. Reinf. inactive responses	6.4	7.6	9.9	-2.8	-3.1	2.1	2.8	-2.3	-3.1
Incentive salience index mean	0.4	0.5	1.3	0.8	0.6	0.1	-0.8	-0.0	1.1
Condit. Reinf. lever presses	0.5	0.7	0.9	0.9	0.7	1.0	-0.9	-0.8	0.8
Time in familiar zone, hab. session 1	3.1	2.9	3.6	-1.8	-1.7	1.5	1.8	-1.6	-1.9
Time in novel zone, hab. session 1	2.7	2.6	3.1	1.6	1.8	-1.4	-1.6	1.5	1.7
Total zone transitions, hab. session 1	2.3	3.3	6.4	-2.3	-1.6	0.4	2.3	-0.6	-2.5
Total locomotion distance, hab. session 1	0.5	0.8	1.9	-1.1	-0.5	0.1	1.1	-0.2	-1.4
Locomotion velocity, hab. session 1	0.8	1.1	2.4	-1.3	-0.9	0.3	1.3	-0.4	-1.5
Time in familiar zone, hab. session 2	1.9	2.0	3.5	-1.5	-0.9	1.2	1.5	-1.3	-1.9
Time in novel zone, hab. session 2	4.7	4.7	6.8	2.1	1.6	-2.2	-2.1	2.3	2.6
Total zone transitions, hab. session 2	0.4	0.5	1.4	-0.9	-0.3	0.1	0.9	-0.2	-1.2
Total locomotion distance, hab. session 2	0.0	0.1	0.1	-0.0	0.3	-0.4	0.0	0.3	-0.2
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.0	0.2	-0.2	-0.0	0.2	-0.2
Novel to familiar place preference ratio	0.3	0.3	1.2	-0.5	-1.1	0.4	0.5	-0.4	-0.2
Novelty place preference	0.1	0.2	0.6	-0.1	-0.8	0.4	0.1	-0.4	0.0
Time in novel zone, NPP test	0.2	0.2	0.5	-0.1	-0.7	0.5	0.1	-0.5	-0.1
Total zone transitions, NPP test	1.0	1.5	3.4	-1.6	-0.5	-0.2	1.6	-0.1	-1.8
Total locomotion distance, NPP test	0.7	0.9	1.9	-1.2	-0.6	-0.4	1.2	0.2	-1.4
Locomotion velocity, NPP test	0.6	0.9	1.6	-1.2	-0.7	-0.5	1.3	0.3	-1.2
Pavlov. Cond. lever latency	0.7	0.8	1.5	-1.1	-1.0	0.1	1.1	-0.3	-1.2
Pavlov. Cond. magazine entry latency	0.4	0.6	1.1	0.7	0.2	1.0	-0.8	-0.9	0.7
Pavlov. Cond. change in total contacts	0.4	0.4	0.8	0.7	0.5	-0.4	-0.7	0.5	0.9
Pavlov. Cond. index score	0.6	0.7	1.1	1.0	0.9	0.5	-1.1	-0.4	1.0
Pavlov. Cond. latency score	0.9	1.2	1.9	1.4	1.3	0.3	-1.4	-0.1	1.3
Pavlov. Cond. lever contacts	0.6	0.7	1.0	1.0	1.0	-0.1	-1.0	0.2	1.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	-0.3	-0.1	-0.7	0.3	0.7	-0.3
Pavlov. Cond. intertrial magazine entries	1.3	1.6	3.0	-1.6	-1.0	-0.5	1.6	0.2	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	0.8	0.7	0.8	-0.8	-0.6	0.7
Pavlov. Cond. response bias	0.2	0.3	0.4	0.6	0.3	0.6	-0.6	-0.5	0.4
Bone: apparent density	2.3	3.8	6.3	-1.4	-1.6	2.5	1.3	-2.5	-2.1
Bone surface	2.1	3.7	5.4	-1.8	-1.7	1.9	1.8	-2.0	-2.3
Bone volume	2.4	4.1	5.8	-1.9	-1.7	2.0	1.8	-2.1	-2.4
Bone: connectivity density	3.6	5.6	8.1	-1.9	-1.9	2.8	1.8	-2.8	-2.6
Bone: cortical apparent density	0.3	0.4	0.9	-0.7	-0.9	0.0	0.6	-0.1	-0.7
Bone: cortical area	0.6	1.0	1.6	0.8	0.5	-1.2	-0.8	1.3	1.0
Bone: cortical porosity	0.0	0.0	0.1	0.0	0.2	0.2	0.0	-0.2	-0.2
Bone: cortical porosity	0.0	0.0	0.1	0.2	0.3	-0.2	-0.2	0.2	0.2
Bone: cortical thickness	3.7	6.2	8.0	2.3	2.0	-2.8	-2.3	2.8	2.7
Bone: cortical thickness	1.7	2.0	2.7	1.6	1.4	-1.1	-1.6	1.2	1.6
Bone: cortical tissue density	0.3	0.4	0.9	-0.7	-1.0	0.1	0.6	-0.2	-0.7
Bone: elastic displacement	0.1	0.1	0.1	-0.3	-0.2	-0.4	0.4	0.3	-0.2
Bone: elastic work	3.1	4.1	5.6	1.7	1.7	-2.3	-1.7	2.4	2.2
Bone: endosteal estimation	0.1	0.3	0.5	-0.7	-0.4	0.3	0.7	-0.3	-0.6
Bone: endosteal perimeter	1.6	3.2	4.2	-1.9	-2.0	1.4	1.9	-1.5	-1.9
Bone: final force	1.8	3.0	4.2	1.8	1.6	-1.5	-1.8	1.6	2.0
Bone: final moment	1.3	2.2	3.2	1.5	1.3	-1.2	-1.5	1.3	1.8
Bone: marrow area	0.1	0.3	0.5	-0.7	-0.4	0.3	0.7	-0.4	-0.6
Bone: maximum diameter	0.7	1.2	2.6	-1.1	-1.6	0.8	1.1	-0.8	-0.9
Bone: maximum force	1.5	2.6	3.3	1.6	1.5	-1.5	-1.6	1.6	1.8
Bone: maximum moment	1.0	1.8	2.3	1.3	1.2	-1.3	-1.3	1.3	1.5
Bone: minimum diameter	1.0	1.8	2.0	1.4	1.3	-1.3	-1.4	1.4	1.3
Bone: periosteal estimation	0.1	0.2	0.4	0.3	0.3	-0.7	-0.3	0.7	0.5
Bone: periosteal perimeter	0.2	0.3	0.8	-0.6	-0.9	0.2	0.6	-0.2	-0.4
Bone: post-yield work	0.1	0.1	0.2	0.4	0.5	0.3	-0.4	-0.3	0.1
Bone: stiffness	0.3	0.4	1.0	0.7	1.0	0.4	-0.8	-0.3	0.3
Bone: tissue strength	2.5	2.4	3.3	1.3	1.3	-1.8	-1.2	1.8	1.8
Bone: trabecular number	2.6	4.1	5.8	-1.6	-1.6	2.4	1.6	-2.4	-2.4
Bone: trabecular spacing	0.3	0.4	0.9	0.4	0.3	-0.8	-0.4	0.8	1.0
Bone: trabecular thickness	0.2	0.3	0.4	-0.4	-0.6	0.5	0.4	-0.5	-0.6
Bone: trabecular tissue density	0.8	1.1	2.0	0.8	0.5	-1.4	-0.8	1.4	1.1
Breakpoint value in progressive ratio session	0.3	0.3	0.6	0.6	0.8	0.4	-0.6	-0.3	0.3
Distance traveled before self-admin	1.1	1.2	2.8	0.5	0.8	-1.7	-0.5	1.6	0.8
Distance traveled after self-admin	0.3	0.3	0.7	0.5	0.8	-0.2	-0.5	0.3	0.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.4	-0.0	-0.4	0.4	0.3	-0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.2	0.3	0.5	-0.2	-0.4	0.0
Diff in mean of infusions in LGA sessions	0.5	0.6	0.8	0.9	0.7	0.7	-0.9	-0.5	0.9
Extinction: sum of active levers before priming	1.4	1.4	3.0	-0.8	-0.4	1.7	0.8	-1.7	-1.1
Active lever presses in extinction session 6	0.8	0.7	1.5	-0.6	-0.4	1.2	0.7	-1.2	-0.6
Delta distance traveled before/after self-admin	0.6	0.7	2.1	0.2	0.1	1.5	-0.2	-1.3	-0.0
Delta ambulatory time before/after self-admin	0.6	0.6	1.9	0.1	0.0	1.4	-0.2	-1.3	-0.0
Time in closed arm before self-admin	0.3	0.4	1.0	0.2	0.4	1.0	-0.2	-0.9	-0.3
Time in closed arm after self-admin	0.0	0.0	0.1	0.1	0.2	-0.3	-0.1	0.3	0.1
Time in open arm before self-admin	1.9	2.0	3.8	0.9	0.7	-1.9	-0.9	1.9	1.5
Time in open arm after self-admin	0.3	0.3	0.8	0.4	0.3	-0.6	-0.4	0.6	0.9
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.6	0.3	0.3	1.3	-0.3	-1.1	0.0
Time to tail flick, vehicle, before self-admin	2.8	2.8	5.6	-1.1	-0.8	2.4	1.1	-2.3	-1.7
Time to tail flick, vehicle, after self-admin	1.7	1.8	2.9	-1.6	-1.7	0.5	1.6	-0.7	-1.5
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.5	-0.4	0.6	0.5	-0.6	-0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	0.2	0.5	-0.4	-0.4	0.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.9	-0.8	-1.0	-0.7	0.8	0.5	-0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	-0.3	-0.3	0.6	0.3	-0.6	-0.3
Ambulatory time before self-admin	2.3	2.4	4.1	1.2	1.4	-2.0	-1.2	2.0	1.4
Ambulatory time after self-admin	1.5	1.6	2.7	1.5	1.7	-0.4	-1.5	0.5	1.4
Total heroin consumption	0.9	1.1	3.3	-0.0	-0.2	1.8	-0.0	-1.7	-0.3
Area under the delay curve	1.6	1.7	2.8	1.0	1.4	-1.7	-1.0	1.7	1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.4	-0.3	0.4	-0.6	0.2	0.5	-0.1
Delay disc. indifference point, 16s delay	0.7	0.7	1.3	0.5	1.1	-1.1	-0.5	1.1	0.4
Delay disc. indifference point, 2s delay	1.3	1.5	3.1	0.8	1.1	-1.8	-0.8	1.7	0.5
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	0.4	0.4	-0.5	-0.4	0.5	0.4
Delay disc. indifference point, 4s delay	1.3	1.3	1.8	1.0	1.2	-1.3	-1.1	1.3	0.9
Delay disc. indifference point, 8s delay	0.9	0.9	1.4	0.8	1.0	-1.2	-0.8	1.2	0.9
Delay discount exponential model param	1.8	1.9	2.6	-1.1	-1.5	1.6	1.2	-1.6	-1.2
Delay discount hyperbolic model param	1.6	1.7	2.5	-1.0	-1.4	1.6	1.0	-1.6	-1.0
Fecal boli incidents, locomotor time 1	0.1	0.1	0.4	0.1	0.6	0.0	-0.1	0.1	-0.1
Change in fecal boli incidents, locomotor task	0.5	0.5	1.2	0.9	0.2	-0.4	-0.8	0.4	1.1
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.0	-0.5	-1.0	1.0	0.5	-0.9	-0.0
Bouts of movement, locomotor time 1	0.4	0.4	1.0	-0.4	-0.7	1.0	0.5	-0.9	0.0
Total resting periods, locomotor time 1	0.7	0.8	1.5	-0.5	-1.1	1.2	0.6	-1.2	-0.1
Rest time, locomotor task time 1	0.7	0.8	2.1	-0.8	-1.4	0.8	0.8	-0.7	-0.5
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.3	0.3	0.4	0.3	-0.4	-0.4
Vertical activity count, locomotor time 1	0.4	0.4	0.9	-0.8	-0.2	0.5	0.8	-0.5	-1.0
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.8	0.6	0.3	-0.5	-0.6	0.6	1.3
Bouts of movement, locomotor time 2	0.1	0.2	0.2	0.5	0.3	-0.4	-0.5	0.3	0.4
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.2	-0.0	-0.0	-0.3	-0.1	0.2
Rest time, locomotor task time 2	0.5	0.6	1.2	-0.5	-1.1	0.8	0.5	-0.9	-0.7
Distance moved, locomotor task time 2	0.3	0.3	0.7	-0.8	-0.0	-0.4	0.9	0.3	-0.4
Vertical activity count, locomotor time 2	0.4	0.4	1.0	0.3	0.5	-0.9	-0.2	1.0	0.5
Weight adjusted by age	0.4	0.5	0.6	-0.7	-0.8	0.7	0.6	-0.7	-0.8
Seeking ratio, delayed vs. immediate footshock	0.9	1.0	3.3	-0.2	-0.1	-1.8	0.3	1.7	0.1
Locomotion in novel chamber	1.4	1.7	3.0	-1.7	-1.6	-0.7	1.7	0.5	-1.1
Locomotion in novel chamber post-restriction	0.4	0.5	0.7	-0.8	-0.8	0.6	0.8	-0.6	-0.8
Progressive ratio	1.0	1.2	2.1	-1.3	-1.4	0.1	1.3	-0.2	-1.2
Food seeking constrained by brief footshock	0.1	0.1	0.2	0.1	0.2	-0.4	-0.0	0.4	0.1
Seeking ratio, punishment vs. effort	1.2	1.5	2.5	1.3	1.6	-0.7	-1.3	0.8	1.3
Run reversals in cocaine runway, females	0.5	0.5	0.8	-0.9	-0.7	-0.4	0.9	0.3	-0.8
Run reversals in cocaine runway, males	1.2	1.1	1.8	-1.2	-1.2	0.5	1.2	-0.6	-1.3
Latency to leave start box in cocaine runway	0.3	0.4	0.5	0.5	0.5	-0.7	-0.6	0.7	0.5
Latency to leave start box in cocaine runway, F	0.6	0.7	0.8	0.8	0.8	-0.9	-0.9	0.9	0.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	0.2	0.0	-0.2	0.0	0.4
Cd content in liver	1.2	1.3	2.4	-0.9	-1.2	1.0	0.9	-1.1	-1.6
Co content in liver	0.2	0.3	0.6	0.3	0.8	-0.6	-0.3	0.6	0.4
Cu content in liver	1.2	1.4	1.9	1.2	1.2	-1.0	-1.3	1.1	1.4
Fe content in liver	0.6	0.7	1.3	1.1	0.9	-0.2	-1.1	0.3	0.8
K content in liver	3.1	3.1	5.4	1.8	2.3	-1.1	-1.8	1.2	1.9
Mg content in liver	0.0	0.0	0.1	-0.2	0.0	-0.1	0.3	0.1	0.1
Mn content in liver	0.3	0.3	0.4	-0.5	-0.5	0.6	0.5	-0.7	-0.5
Na content in liver	3.5	3.7	4.7	1.6	1.9	-2.1	-1.5	2.2	2.0
Rb content in liver	1.7	2.1	2.4	-1.5	-1.3	1.3	1.5	-1.4	-1.5
Se content in liver	0.8	1.0	1.4	1.0	0.7	-1.0	-1.0	1.1	1.2
Sr content in liver	0.7	0.7	1.1	-0.7	-0.5	1.1	0.7	-1.1	-0.8
Zn content in liver	1.2	1.3	1.5	-1.1	-1.2	1.2	1.1	-1.2	-1.0