Hub : Genes

Mnt

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	ENSRNOG00000002894	0.06	0.07	3.7e-03	0.02	0.01	0.02	0.01	4.7e-03	1.5e-02	1.1e-02	2.1e-02
2	LHb	intron excision ratio	chr10:59706563:59711286	0.57	0.25	1.5e-03	0.13	0.09	0.1	0.14	4.5e-04	3.1e-03	1.9e-03	3.9e-04
3	LHb	intron excision ratio	chr10:59709191:59711286	0.7	0.18	1.4e-03	0.13	0.11	0.06	0.13	6.5e-04	1.7e-03	1.9e-02	6.0e-04
4	NAcc	gene expression	ENSRNOG00000002894	0.07	0.05	7.1e-04	0.03	0.04	0.03	0.03	1.6e-03	1.1e-03	1.7e-03	3.2e-03
5	PL	mRNA stability	ENSRNOG00000002894	0.03	0.03	4.3e-03	0.03	0.02	0.01	0.02	4.8e-03	7.0e-03	4.6e-02	1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	1.1	3.4	6.0	-2.4	0.9	-0.9	-1.9	-2.4
BMI without tail	0.3	0.7	1.1	-1.1	0.9	-0.9	-0.6	-0.7
Body weight	1.4	5.8	9.4	-2.1	3.1	-3.1	-2.4	-0.0
Epididymis fat weight	3.5	8.2	12.4	-3.5	2.9	-2.9	-3.2	-1.4
Glucose	2.3	3.6	6.7	1.9	-1.9	1.9	2.6	0.5
Heart weight	0.1	0.2	0.4	-0.6	0.5	-0.5	-0.3	-0.2
Left kidney weight	1.8	5.1	8.9	3.0	-0.4	0.5	2.9	2.8
Right kidney weight	1.5	4.3	7.8	2.7	-0.2	0.2	2.6	2.8
Tail length	2.1	6.3	11.1	0.8	3.1	-3.1	-0.5	3.3
Length with tail	1.3	4.8	7.7	0.3	2.8	-2.8	-1.0	2.7
Length without tail	1.0	2.3	3.6	-0.9	1.9	-1.9	-1.7	0.6
Liver weight, left	1.1	1.7	3.4	0.5	1.6	-1.6	-0.0	1.8
Liver weight, right	0.8	1.3	2.4	-0.3	1.5	-1.5	-0.6	1.1
Parametrial fat weight	6.8	13.2	19.7	-2.9	4.4	-4.4	-4.3	-0.2
Retroperitoneal fat weight	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	-0.1
Intraocular pressure	1.5	2.1	5.2	-1.4	-1.3	1.3	-0.1	-2.3
Extensor digitorum longus weight	3.5	14.2	24.2	-4.9	1.9	-1.9	-4.9	-4.0
Soleus weight	3.2	9.2	12.9	-2.9	3.6	-3.6	-3.5	-0.3
Tibialis anterior weight	6.3	21.7	36.5	-5.8	3.3	-3.3	-6.0	-4.0
Tibia length	1.0	2.8	7.3	1.8	1.3	-1.2	0.6	2.7
Number of licking bursts	0.3	0.4	0.4	0.6	-0.6	0.6	0.7	0.5
Food consumed during 24 hour testing period	0.3	0.4	0.5	-0.7	0.6	-0.6	-0.7	-0.5
Times rat made contact with spout	0.7	0.8	1.6	1.3	0.1	-0.1	1.2	1.1
Mean time between licks in bursts	0.4	0.6	1.3	0.4	0.9	-0.9	-0.2	1.2
Mean num. licks in bursts	0.2	0.2	0.5	0.3	0.7	-0.7	0.2	0.3
Std. dev. time between licks in bursts	0.2	0.2	0.4	-0.5	0.2	-0.2	-0.6	-0.6
Water consumed over 24 hours	0.7	0.8	2.2	0.8	0.8	-0.7	0.3	1.5
Indifference point 0 sec	0.1	0.2	0.3	-0.4	0.3	-0.3	-0.5	-0.5
Indifference point AUC	0.6	0.7	1.2	-0.3	-1.1	1.1	0.4	-0.9
Indifference point function ln k	0.5	0.7	1.4	-0.7	0.9	-0.9	-1.2	-0.0
Indifference point function log k	0.5	0.7	1.4	-0.7	0.9	-0.9	-1.2	-0.0
Delay discounting total patch changes 0 sec	0.1	0.2	0.3	-0.4	0.2	-0.2	-0.5	-0.5
Delay discounting total patch changes 12 sec	0.5	0.6	1.2	1.1	-0.5	0.6	0.9	0.6
Delay discounting total patch changes 18 sec	0.3	0.4	0.9	0.7	-0.4	0.4	1.0	0.4
Delay discounting total patch changes 24 sec	0.6	0.7	1.3	0.9	-0.8	0.9	1.1	-0.1
Delay discounting total patch changes 6 sec	0.3	0.4	0.8	0.2	-0.9	0.9	0.4	-0.7
Delay discounting time to switch 0 sec	1.2	1.9	4.6	1.9	0.3	-0.3	1.1	2.1
Delay discounting water rate 0 sec	0.4	0.6	1.5	-0.8	-0.5	0.5	-0.5	-1.2
Delay discounting water rate 12 sec	0.1	0.1	0.4	-0.7	0.3	-0.3	-0.2	-0.2
Delay discounting water rate 18 sec	2.3	3.1	5.6	-2.4	1.2	-1.2	-2.2	-1.4
Delay discounting water rate 24 sec	0.2	0.3	0.7	-0.6	-0.1	0.1	-0.5	-0.9
Delay discounting water rate 6 sec	0.2	0.3	0.7	0.1	-0.8	0.8	0.4	-0.4
Locomotor activity	0.2	0.4	0.6	-0.8	0.6	-0.6	-0.2	-0.7
Locomotor testing distance	0.0	0.1	0.1	-0.0	0.4	-0.4	-0.1	-0.3
Locomotor testing rearing	0.4	0.6	1.7	-0.9	-0.0	0.0	-0.6	-1.3
Light reinforcement 1	0.0	0.0	0.1	-0.3	0.1	-0.1	-0.3	-0.1
Light reinforcement 2	1.8	2.4	4.1	2.0	-0.8	0.9	1.8	1.7
Reaction time number correct	0.1	0.1	0.3	-0.5	0.4	-0.4	-0.3	-0.4
Reaction time mean minus median	0.2	0.3	0.7	0.4	-0.8	0.8	0.1	0.1
Reaction time mean minus median AUC	0.4	0.5	0.9	-0.7	-0.4	0.4	-1.0	-0.8
Reaction time num false alarms	0.8	1.2	2.6	-0.7	-1.2	1.2	-0.1	-1.6
Reaction time num false alarms AUC	0.8	1.2	2.7	-0.6	-1.2	1.2	-0.1	-1.6
Reaction time trials correct on left	0.1	0.1	0.3	-0.5	0.4	-0.4	-0.3	-0.4
Reaction time trials on left	0.1	0.1	0.3	-0.5	0.3	-0.3	-0.3	-0.4
Reaction time mean	0.3	0.4	0.7	0.8	-0.5	0.5	0.4	0.8
Reaction time mean AUC	0.5	0.6	0.8	0.9	-0.9	0.9	0.6	0.6
Median of all reaction times	0.4	0.5	0.9	0.9	-0.4	0.4	0.6	1.0
Reaction time omissions	0.1	0.1	0.3	0.6	-0.1	0.1	0.2	0.2
Reaction time false alarm rate	0.6	0.8	1.6	-0.4	-1.1	1.1	-0.1	-1.3
Reaction time premature initiation rate	0.3	0.5	0.9	-1.0	0.4	-0.4	-1.0	-0.4
Reaction time premature initiations	0.5	0.8	1.6	-1.3	0.5	-0.5	-1.1	-0.7
Std. dev. reaction times	0.3	0.4	0.7	0.6	-0.9	0.9	0.2	0.2
Reaction time trials completed	0.1	0.1	0.3	-0.5	0.3	-0.3	-0.3	-0.4
Reaction time trials AUC	0.1	0.2	0.3	-0.5	0.3	-0.3	-0.3	-0.5
Social response proportion	2.7	2.9	5.6	-0.4	2.4	-2.4	-1.4	1.2
Social responses	1.7	2.1	3.6	-0.9	1.9	-1.9	-1.6	0.2
Social time	2.0	2.6	4.9	-0.6	2.0	-1.9	-2.2	0.5
Conditioned locomotion	0.8	0.9	1.5	1.2	-1.1	1.1	0.8	0.5
Cocaine response after cond. corrected	0.3	0.3	0.6	0.2	0.7	-0.7	-0.2	0.8
Cocaine response after cond. not corrected	0.5	0.5	1.0	-0.2	1.0	-1.0	-0.6	0.6
Cocaine response before conditioning	1.0	1.2	1.8	-1.3	1.0	-1.0	-1.3	-0.8
Saline control response	0.6	0.8	1.7	-1.3	0.2	-0.3	-0.9	-1.2
Condit. Reinf. active minus inactive responses	0.7	0.8	1.9	-1.4	0.4	-0.4	-0.8	-1.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.1	0.2	-0.2	0.1	0.2
Condit. Reinf. active responses	1.6	2.2	4.8	-2.2	0.2	-0.2	-1.3	-2.2
Condit. Reinf. inactive responses	2.9	3.7	9.3	-2.5	-0.2	0.2	-1.6	-3.0
Condit. Reinf. lever presses	0.6	0.9	1.4	-0.3	-1.2	1.1	0.3	-1.2
Condit. Reinf. lever reinforcers received	1.7	2.4	5.7	-2.2	0.0	-0.1	-1.1	-2.4
Pavlov. Cond. lever latency	0.8	1.1	1.8	-0.5	1.3	-1.3	-1.3	0.2
Pavlov. Cond. magazine entry latency	0.7	0.8	1.5	1.1	-0.3	0.3	1.2	1.1
Pavlov. Cond. change in total contacts	0.5	0.6	1.5	0.8	-0.8	0.8	1.2	0.1
Pavlov. Cond. index score	1.0	1.3	2.4	0.8	-1.3	1.3	1.6	0.1
Pavlov. Cond. latency score	1.3	1.7	2.8	1.0	-1.5	1.5	1.7	0.1
Pavlov. Cond. lever contacts	0.4	0.6	1.2	0.7	-0.8	0.8	1.1	0.3
Pavlov. Cond. magazine entry number	0.8	1.0	2.0	-1.2	0.6	-0.6	-1.4	-0.8
Pavlov. Cond. intertrial magazine entries	1.6	2.1	3.7	-1.9	0.9	-0.9	-1.9	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.2	0.8	-1.3	1.3	1.5	0.1
Pavlov. Cond. response bias	0.6	0.8	1.9	0.9	-0.8	0.8	1.4	0.6
Conditioned reinforcement - actives	2.1	2.0	3.8	-1.9	0.6	-0.6	-1.5	-1.9
Conditioned reinforcement - inactives	0.9	1.0	2.4	-1.6	-0.0	-0.0	-0.8	-1.4
Conditioned locomotion	0.1	0.1	0.3	0.1	-0.3	0.3	0.4	-0.5
Intermittent access intake day 1-15 change	1.5	1.5	3.2	-0.3	-1.4	1.4	0.2	-1.8
Intermittent access intake escalation	1.7	1.7	3.0	0.2	-1.7	1.7	0.9	-1.4
Intermittent access intake escalation 2	2.1	2.1	3.8	1.1	-1.9	2.0	1.3	-0.4
Intermitt. access day 1 inactive lever presses	1.8	1.9	3.9	0.8	-1.6	1.6	2.0	0.1
Intermitt. access day 15 inactive lever presses	0.5	0.6	1.0	-0.4	-1.0	1.0	0.7	-0.2
Intermitt. access escalation Index	3.7	3.3	5.8	0.6	2.4	-2.4	-0.7	2.1
Intermittent access day 1 total infusions	0.8	0.9	2.1	-1.4	0.5	-0.5	-0.9	-1.0
Intermittent access day 15 total infusions	1.5	1.7	5.2	-1.4	-0.7	0.7	-0.6	-2.3
Intermittent access terminal intake (last 3 days)	1.2	1.3	2.4	-1.5	0.3	-0.3	-1.3	-1.5
Intermittent access total infusions	0.9	1.0	2.6	-1.3	-0.3	0.3	-0.6	-1.6
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.2	-0.1	0.1	0.6	-0.2
Intermittent access day 15 total locomotion	0.6	0.6	0.9	-0.2	-0.9	0.9	0.6	-1.0
Intermittent access total locomotion	0.2	0.2	0.4	-0.4	-0.4	0.4	0.3	-0.6
Intermittent access standard deviation	3.1	3.3	5.6	-0.7	-2.2	2.2	0.6	-2.4
Cocaine induced anxiety	0.5	0.5	0.9	-0.3	-0.9	0.9	0.1	-0.9
Post-drug Anxiety	0.1	0.1	0.2	-0.4	-0.2	0.2	-0.4	-0.3
Baseline Anxiety	0.1	0.1	0.2	0.1	0.5	-0.5	-0.1	0.5
Lifetime Intake	1.0	1.1	2.9	-1.4	-0.4	0.4	-0.6	-1.7
Incentive Sensitization - Responses	0.9	0.9	2.4	-1.6	-0.4	0.4	-0.2	-1.4
Incentive Sensitization - Breakpoint	0.7	0.7	1.8	-1.4	-0.4	0.4	-0.1	-1.2
Progressive ratio test 1 active lever presses	1.1	1.2	3.3	-1.8	0.4	-0.4	-0.7	-1.4
Progressive ratio test 1 breakpoint	1.8	1.8	4.9	-2.2	0.7	-0.7	-1.1	-1.4
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.8	-0.4	-0.9	0.9	0.8	-0.6
Progressive ratio test 2 active lever presses	1.4	1.5	3.8	-2.0	-0.3	0.2	-0.5	-1.8
Progressive ratio test 2 breakpoint	1.4	1.6	3.9	-2.0	-0.4	0.3	-0.5	-1.9
Progressive ratio test 2 inactive lever presses	1.1	1.3	2.8	-1.6	-0.8	0.7	-0.0	-1.7
Total sessions with >9 infusions	0.3	0.3	0.7	-0.8	0.2	-0.2	-0.4	-0.8
Short access day 1 total inactive lever presses	0.2	0.2	0.2	-0.5	0.4	-0.4	-0.4	-0.3
Short access day 10 total inactive lever presses	0.2	0.2	0.4	0.4	0.1	-0.1	0.6	0.6
Short access day 1 total infusions	1.1	1.2	2.6	-0.7	-1.2	1.2	0.2	-1.6
Short access day 10 total infusions	1.7	1.8	4.6	-2.0	-0.1	0.0	-0.8	-2.1
Short access total infusions	0.9	1.0	2.8	-1.1	-0.7	0.7	-0.3	-1.7
Short access day 1 locomotion	0.5	0.5	1.3	-0.3	-0.7	0.7	0.5	-1.1
Short access day 10 total locomotion	0.3	0.4	0.8	0.2	-0.7	0.6	0.9	-0.4
Short access total locomotion	0.5	0.5	1.1	-0.4	-0.7	0.7	0.5	-1.1
Compulsive drug intake	0.9	0.9	2.3	0.8	0.9	-0.8	-0.1	1.5
One hour access (0.3 mA shock)	1.6	1.9	4.3	-1.9	-0.1	0.1	-1.2	-2.1
One hour access (shock baseline)	1.8	2.1	5.6	-2.0	-0.5	0.4	-0.7	-2.4
Number of responses in last shaping day	1.0	1.0	1.4	0.3	-1.2	1.2	1.2	-1.0
Context. condit. distance diff. score	1.1	1.4	2.2	-1.3	1.2	-1.2	-1.5	-0.2
Locomotion velocity, session 1	3.0	3.2	4.5	-1.6	2.1	-2.1	-2.1	0.2
Locomotion distance, session 1	0.4	0.6	1.2	-0.9	0.5	-0.5	-1.1	-0.6
Locomotion velocity, session 2	0.6	0.7	1.4	-0.8	0.9	-0.9	-1.2	-0.1
Locomotion distance, session 2	1.2	1.8	3.0	-1.7	0.9	-1.0	-1.7	-1.0
Locomotion velocity, session 3	3.7	4.3	8.1	2.8	-1.3	1.3	2.6	1.9
Locomotion distance, session 3	0.2	0.2	0.6	-0.1	-0.4	0.4	0.1	-0.8
Stereotopy head waving bouts, day 3	0.4	0.5	1.6	0.7	0.5	-0.5	-0.0	1.3
Stereotopy head waving duration, day 3	0.4	0.4	0.7	0.8	-0.6	0.6	0.4	0.7
Locomotion velocity, session 7	1.4	1.5	3.1	-1.7	0.4	-0.4	-1.0	-1.8
Locomotion distance, session 7	2.2	2.8	6.1	-2.5	0.7	-0.8	-1.5	-2.2
Stereotopy head waving bouts, day 7	0.6	0.7	1.7	-0.5	0.9	-0.9	-1.3	0.2
Stereotopy head waving duration, day 7	0.8	1.0	2.3	-0.8	1.0	-1.0	-1.5	-0.1
Locomotion velocity, session 8	0.3	0.3	0.8	-0.6	0.4	-0.4	-0.9	-0.2
Locomotion distance, session 8	2.1	3.1	4.7	-1.9	1.9	-1.9	-2.2	-0.3
Degree of sensitization distance	1.4	1.4	2.5	-1.6	1.2	-1.2	-1.2	-0.5
Degree of sensitization stereotypy	1.1	1.2	2.2	-0.8	1.3	-1.3	-1.5	0.3
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.6	0.1	-0.1	0.4	0.6
Condit. Reinf. active-inactive response ratio	1.7	1.8	3.5	1.9	0.1	-0.1	1.5	1.8
Condit. Reinf. active responses	0.2	0.3	0.5	-0.7	0.3	-0.3	-0.6	-0.5
Condit. Reinf. inactive responses	2.8	3.3	6.3	-2.5	-0.1	0.0	-1.9	-2.5
Incentive salience index mean	0.2	0.3	0.6	0.6	0.5	-0.5	0.1	0.8
Condit. Reinf. lever presses	0.8	1.1	2.1	-0.1	1.4	-1.4	-0.8	0.7
Time in familiar zone, hab. session 1	1.0	0.9	2.2	-1.1	-0.4	0.4	-0.8	-1.5
Time in novel zone, hab. session 1	0.9	0.8	2.5	0.9	0.3	-0.3	0.8	1.6
Total zone transitions, hab. session 1	1.5	2.1	4.6	-2.1	-0.0	-0.0	-1.7	-1.7
Total locomotion distance, hab. session 1	0.4	0.6	1.4	-1.2	0.2	-0.2	-1.1	-0.6
Locomotion velocity, hab. session 1	0.4	0.6	1.2	-1.1	0.1	-0.1	-1.1	-0.7
Time in familiar zone, hab. session 2	1.2	1.3	2.5	-1.6	0.4	-0.4	-1.5	-1.2
Time in novel zone, hab. session 2	3.1	3.1	5.8	2.4	-0.7	0.7	2.3	1.9
Total zone transitions, hab. session 2	0.8	1.0	2.0	-1.3	0.8	-0.8	-1.4	-0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.3	0.1	0.4	-0.4	-0.4	0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.1	0.3	-0.3	-0.3	0.6
Novel to familiar place preference ratio	0.5	0.6	1.4	-0.3	-0.7	0.7	0.5	-1.2
Novelty place preference	0.2	0.2	0.5	-0.2	-0.3	0.3	0.3	-0.7
Time in novel zone, NPP test	0.1	0.2	0.6	-0.4	-0.1	0.1	0.0	-0.8
Total zone transitions, NPP test	0.9	1.3	2.7	-1.7	0.2	-0.3	-1.4	-1.3
Total locomotion distance, NPP test	0.3	0.4	0.7	-0.7	-0.4	0.4	-0.5	-0.8
Locomotion velocity, NPP test	0.3	0.5	0.8	-0.3	-0.9	0.9	-0.0	-0.8
Pavlov. Cond. lever latency	0.3	0.4	0.8	-0.6	-0.5	0.5	-0.3	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.7	1.3	0.1	1.1	-1.1	-0.5	0.8
Pavlov. Cond. change in total contacts	0.5	0.5	1.0	1.0	-0.3	0.3	0.8	0.8
Pavlov. Cond. index score	0.6	0.8	1.3	0.3	1.2	-1.1	-0.4	1.0
Pavlov. Cond. latency score	0.8	1.0	1.7	0.4	1.3	-1.3	-0.3	1.3
Pavlov. Cond. lever contacts	0.3	0.3	0.7	0.5	0.6	-0.6	0.2	0.9
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	-0.1	-0.6	0.5	0.3	-0.5
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.9	-1.0	-0.7	0.7	-0.5	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.0	0.3	1.0	-1.0	-0.4	0.9
Pavlov. Cond. response bias	0.3	0.4	0.6	0.2	0.8	-0.8	-0.4	0.7
Bone: apparent density	3.0	4.9	8.5	-2.6	1.9	-1.9	-2.9	-1.3
Bone surface	2.7	4.8	8.0	-2.8	1.4	-1.5	-2.7	-2.1
Bone volume	3.0	5.0	8.5	-2.9	1.5	-1.5	-2.8	-2.1
Bone: connectivity density	4.2	6.5	11.4	-3.1	2.0	-2.0	-3.4	-1.9
Bone: cortical apparent density	0.4	0.5	1.1	0.3	-1.0	1.0	0.5	-0.2
Bone: cortical area	1.1	1.6	3.7	1.1	-1.3	1.3	1.9	0.0
Bone: cortical porosity	0.2	0.2	0.4	-0.6	0.5	-0.5	-0.4	-0.2
Bone: cortical porosity	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1	-0.0
Bone: cortical thickness	3.6	6.0	10.9	3.2	-1.6	1.7	3.3	1.9
Bone: cortical thickness	0.9	1.0	1.9	1.4	-0.0	0.0	1.2	1.3
Bone: cortical tissue density	0.3	0.4	0.8	0.2	-0.9	0.9	0.4	-0.2
Bone: elastic displacement	0.5	0.6	1.0	0.6	-1.0	1.0	0.7	-0.2
Bone: elastic work	3.3	4.3	8.0	2.8	-1.4	1.5	2.7	1.4
Bone: endosteal estimation	0.2	0.4	1.1	-0.8	-0.1	0.1	-0.4	-1.1
Bone: endosteal perimeter	1.2	2.4	5.8	-2.2	-0.2	0.2	-1.1	-2.4
Bone: final force	0.4	0.7	1.5	1.2	0.3	-0.3	1.0	0.8
Bone: final moment	0.3	0.6	1.3	1.1	0.2	-0.2	1.0	0.6
Bone: marrow area	0.2	0.4	1.0	-0.8	-0.1	0.1	-0.4	-1.0
Bone: maximum diameter	0.5	1.0	3.0	-0.8	-0.8	0.8	0.1	-1.7
Bone: maximum force	0.5	0.9	1.8	1.4	-0.0	0.0	1.2	1.0
Bone: maximum moment	0.4	0.7	1.6	1.3	-0.2	0.2	1.2	0.7
Bone: minimum diameter	0.3	0.6	1.7	0.8	-0.3	0.3	1.3	0.8
Bone: periosteal estimation	0.2	0.4	0.8	0.3	-0.6	0.6	0.9	-0.4
Bone: periosteal perimeter	0.4	0.7	1.8	-0.7	-0.7	0.7	0.4	-1.3
Bone: post-yield work	0.3	0.4	0.7	-0.4	0.8	-0.8	-0.6	0.4
Bone: stiffness	0.9	1.4	2.5	-0.8	1.6	-1.6	-1.1	0.3
Bone: tissue strength	1.7	1.7	3.3	1.8	-0.7	0.8	1.7	1.0
Bone: trabecular number	3.0	4.6	8.7	-2.6	1.7	-1.7	-2.9	-1.3
Bone: trabecular spacing	0.4	0.5	1.3	0.4	-0.7	0.7	1.1	-0.4
Bone: trabecular thickness	0.1	0.2	0.5	-0.1	0.4	-0.4	-0.7	0.2
Bone: trabecular tissue density	1.9	2.7	3.9	2.0	-1.4	1.5	2.0	1.2
Breakpoint value in progressive ratio session	1.1	1.2	2.1	-1.0	1.4	-1.4	-0.9	-0.0
Distance traveled before self-admin	1.5	1.6	2.8	1.2	-1.4	1.4	1.7	0.2
Distance traveled after self-admin	0.0	0.0	0.1	-0.0	0.2	-0.2	0.2	0.0
Delta time in closed arm before/after self-admin	0.4	0.4	0.9	-0.1	-1.0	1.0	0.4	-0.1
Delta time in open arm before/after self-admin	1.1	1.1	1.9	-0.7	1.4	-1.4	-0.9	-0.7
Diff in mean of infusions in LGA sessions	0.6	0.7	1.3	-0.2	1.2	-1.1	-0.5	0.7
Extinction: sum of active levers before priming	2.7	2.7	4.9	-2.2	1.4	-1.5	-1.8	-1.1
Active lever presses in extinction session 6	1.5	1.4	2.1	-1.4	1.0	-1.1	-1.3	-1.1
Delta distance traveled before/after self-admin	1.8	1.9	3.1	-1.1	1.7	-1.7	-1.5	0.0
Delta ambulatory time before/after self-admin	1.3	1.4	2.3	-0.8	1.5	-1.5	-1.4	0.3
Time in closed arm before self-admin	1.5	1.8	2.9	-0.4	1.7	-1.7	-1.6	0.7
Time in closed arm after self-admin	0.3	0.3	0.9	0.5	-0.3	0.3	0.2	0.9
Time in open arm before self-admin	3.4	3.6	7.0	1.3	-2.1	2.1	2.7	0.4
Time in open arm after self-admin	0.6	0.7	1.5	0.2	-0.7	0.7	1.2	-1.0
Sum of active levers in priming session hrs 5-6	2.5	2.4	3.3	-1.8	1.7	-1.8	-1.4	-0.8
Time to tail flick, vehicle, before self-admin	4.7	4.8	7.8	-2.4	2.1	-2.2	-2.8	-1.2
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.2	-0.9	0.0	-0.0	-1.1	-0.8
Time to tail flick, test, before self-admin	0.5	0.5	1.0	0.2	0.5	-0.5	-1.0	0.9
Time to tail flick, test, after self-admin	0.5	0.5	0.8	0.2	0.8	-0.8	-0.5	0.9
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	2.1	1.0	-1.4	1.5	0.8	0.1
Delta time to tail flick, test, before/after SA	0.3	0.3	1.0	-0.7	-0.0	0.0	-0.0	-1.0
Ambulatory time before self-admin	1.7	1.8	3.5	1.6	-1.1	1.1	1.9	0.8
Ambulatory time after self-admin	0.8	0.9	1.4	0.4	1.2	-1.2	-0.0	1.1
Total heroin consumption	4.0	4.8	6.6	-2.2	2.5	-2.6	-2.4	-0.4
Area under the delay curve	0.7	0.7	2.0	0.6	-0.7	0.7	1.4	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.2	-0.6
Delay disc. indifference point, 16s delay	0.4	0.4	1.0	-0.1	-0.7	0.7	1.0	-0.3
Delay disc. indifference point, 2s delay	0.7	0.8	1.5	0.9	-0.7	0.7	1.2	0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	-0.2	-0.3	0.3	0.6	-0.3
Delay disc. indifference point, 4s delay	0.2	0.3	0.8	0.3	-0.1	0.1	0.9	0.6
Delay disc. indifference point, 8s delay	0.3	0.3	0.9	0.4	-0.4	0.4	1.0	0.5
Delay discount exponential model param	0.6	0.7	1.9	-0.7	0.6	-0.6	-1.4	-0.6
Delay discount hyperbolic model param	0.6	0.7	1.8	-0.6	0.6	-0.6	-1.3	-0.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	0.3	0.2	-0.2	-0.2	0.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.7	-0.0	0.1	0.6	0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	-0.2	-0.2	0.2	-0.2	-0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.4	0.2	-0.3	-0.5	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	-0.0	-0.0	-0.5	-0.3
Rest time, locomotor task time 1	0.2	0.2	0.5	0.0	-0.7	0.7	0.0	-0.2
Distance moved, locomotor task time 1	0.2	0.2	0.5	-0.6	0.1	-0.1	-0.2	-0.7
Vertical activity count, locomotor time 1	0.5	0.6	0.9	-0.9	0.5	-0.5	-0.9	-1.0
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.3	0.5	-0.7	0.7	1.1	-0.3
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.0	0.1	-0.1	0.4	0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.3	0.3	-0.3	0.0	-0.1
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.6	-0.2	0.2	-0.3	-0.3
Distance moved, locomotor task time 2	0.3	0.4	0.7	-0.1	-0.8	0.8	0.2	-0.6
Vertical activity count, locomotor time 2	0.3	0.3	0.7	0.8	-0.4	0.4	0.5	0.7
Weight adjusted by age	1.4	1.6	3.4	-1.9	0.7	-0.7	-1.0	-1.6
Seeking ratio, delayed vs. immediate footshock	1.4	1.6	2.8	0.7	-1.7	1.7	1.3	-0.3
Locomotion in novel chamber	3.5	4.3	8.1	0.5	-2.8	2.8	1.5	-1.7
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.3	-0.5
Progressive ratio	0.4	0.4	0.9	-0.5	-0.6	0.6	-0.5	-0.9
Food seeking constrained by brief footshock	0.2	0.2	0.3	0.5	-0.4	0.4	0.4	0.4
Seeking ratio, punishment vs. effort	0.6	0.8	1.8	1.1	0.1	-0.1	0.9	1.3
Run reversals in cocaine runway, females	0.4	0.4	1.1	0.0	-1.0	1.0	0.2	-0.2
Run reversals in cocaine runway, males	0.5	0.5	1.1	-0.4	-0.7	0.7	-0.2	-1.1
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.7	-0.1	0.1	0.3	0.7
Latency to leave start box in cocaine runway, F	0.6	0.7	2.1	1.1	0.2	-0.2	0.2	1.4
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	0.3	-0.3	0.0	-0.2
Cd content in liver	0.9	0.9	2.1	-1.5	0.6	-0.6	-1.2	-0.5
Co content in liver	0.1	0.1	0.3	-0.1	-0.2	0.2	0.5	-0.4
Cu content in liver	0.5	0.6	1.4	1.0	-0.2	0.2	1.2	0.9
Fe content in liver	0.6	0.8	1.6	0.4	1.0	-1.0	-0.2	1.3
K content in liver	0.9	0.9	2.0	1.0	0.9	-0.9	0.4	1.4
Mg content in liver	0.1	0.1	0.4	-0.1	-0.3	0.3	0.2	-0.6
Mn content in liver	0.1	0.1	0.3	-0.2	0.2	-0.2	-0.6	-0.3
Na content in liver	2.0	2.2	3.9	2.0	-0.8	0.8	1.9	1.4
Rb content in liver	1.4	1.7	3.5	-1.8	0.2	-0.2	-1.3	-1.9
Se content in liver	0.8	1.0	1.8	1.3	-0.4	0.5	1.2	1.1
Sr content in liver	0.4	0.4	0.9	-0.7	0.5	-0.5	-1.0	-0.4
Zn content in liver	0.4	0.5	1.3	-0.9	-0.1	0.1	-0.6	-1.1