Hub : Genes

Afm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000002878 0.03 0.03 5.4e-03 0.01 0.01 0.01 0.01 1.8e-02 9.9e-03 1.2e-02 1.3e-02
2 Liver gene expression ENSRNOG00000002878 0.22 0.1 0.0e+00 0.11 0.18 0.19 0.19 2.0e-12 4.1e-19 5.1e-21 4.5e-21
3 Liver mRNA stability ENSRNOG00000002878 0.34 0.11 0.0e+00 0.31 0.32 0.32 0.32 1.3e-34 3.0e-36 5.5e-36 2.6e-36

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail1.23.99.11.6-3.00.0
BMI without tail0.30.61.50.0-1.20.5
Body weight0.31.52.8-1.2-0.31.7
Epididymis fat weight0.20.51.2-0.01.1-0.4
Glucose0.20.30.50.40.6-0.7
Heart weight0.40.61.0-0.8-0.31.0
Left kidney weight0.82.33.2-1.81.41.4
Right kidney weight1.64.56.0-2.42.31.5
Tail length1.75.17.9-2.82.01.8
Length with tail1.86.79.7-2.83.11.6
Length without tail0.71.54.4-0.32.1-0.3
Liver weight, left0.50.81.50.50.7-1.2
Liver weight, right1.01.62.40.31.5-1.6
Parametrial fat weight0.40.71.1-1.0-0.11.0
Retroperitoneal fat weight0.00.20.4-0.10.70.2
Intraocular pressure0.91.31.7-1.30.81.2
Extensor digitorum longus weight3.413.537.21.7-6.10.5
Soleus weight2.67.610.83.3-2.7-2.2
Tibialis anterior weight1.44.78.92.1-3.0-1.0
Tibia length1.13.04.8-2.20.52.0
Number of licking bursts0.10.10.2-0.40.50.1
Food consumed during 24 hour testing period0.10.10.10.2-0.3-0.3
Times rat made contact with spout0.40.50.7-0.80.80.3
Mean time between licks in bursts0.70.91.4-1.20.80.9
Mean num. licks in bursts0.00.00.1-0.20.3-0.1
Std. dev. time between licks in bursts0.20.20.5-0.10.7-0.3
Water consumed over 24 hours0.20.20.4-0.50.70.0
Indifference point 0 sec0.71.22.41.5-0.6-0.9
Indifference point AUC0.50.61.4-0.41.2-0.6
Indifference point function ln k0.71.02.60.6-1.60.4
Indifference point function log k0.71.02.60.6-1.60.4
Delay discounting total patch changes 0 sec0.61.02.11.4-0.5-0.9
Delay discounting total patch changes 12 sec1.41.82.71.50.7-1.7
Delay discounting total patch changes 18 sec0.00.00.0-0.1-0.00.2
Delay discounting total patch changes 24 sec2.12.63.91.90.4-2.0
Delay discounting total patch changes 6 sec1.11.62.61.40.5-1.6
Delay discounting time to switch 0 sec0.20.20.50.0-0.70.5
Delay discounting water rate 0 sec0.20.30.5-0.50.7-0.1
Delay discounting water rate 12 sec0.20.30.70.10.6-0.8
Delay discounting water rate 18 sec0.10.20.30.50.0-0.5
Delay discounting water rate 24 sec0.30.40.6-0.80.40.6
Delay discounting water rate 6 sec0.60.92.00.11.4-0.9
Locomotor activity0.10.20.50.40.2-0.7
Locomotor testing distance1.01.62.51.6-0.5-1.5
Locomotor testing rearing0.71.11.81.4-0.7-0.9
Light reinforcement 10.10.10.20.40.0-0.5
Light reinforcement 20.40.51.20.30.5-1.1
Reaction time number correct0.30.50.7-0.8-0.10.8
Reaction time mean minus median1.21.52.5-1.60.61.3
Reaction time mean minus median AUC1.72.23.3-1.80.71.6
Reaction time num false alarms1.42.02.91.50.8-1.7
Reaction time num false alarms AUC1.62.23.21.70.7-1.8
Reaction time trials correct on left0.30.50.7-0.8-0.10.8
Reaction time trials on left0.40.50.8-0.9-0.20.9
Reaction time mean1.21.72.7-1.50.11.6
Reaction time mean AUC0.91.21.8-1.30.21.4
Median of all reaction times0.91.21.9-1.20.11.4
Reaction time omissions0.81.11.8-0.7-1.01.3
Reaction time false alarm rate1.92.73.81.90.9-2.0
Reaction time premature initiation rate0.30.40.60.60.4-0.8
Reaction time premature initiations0.00.10.10.10.3-0.3
Std. dev. reaction times0.71.01.5-1.20.31.2
Reaction time trials completed0.40.50.8-0.9-0.20.9
Reaction time trials AUC0.50.71.1-1.0-0.21.1
Social response proportion0.50.50.7-0.80.80.5
Social responses0.40.50.80.90.2-0.8
Social time0.10.20.3-0.50.30.4
Conditioned locomotion0.60.71.8-0.61.3-0.1
Cocaine response after cond. corrected0.30.30.6-0.70.60.1
Cocaine response after cond. not corrected0.20.20.5-0.7-0.40.3
Cocaine response before conditioning1.21.53.80.0-2.00.7
Saline control response0.20.30.80.3-0.9-0.1
Condit. Reinf. active minus inactive responses0.81.01.61.1-1.3-0.5
Condit. Reinf. active-inactive response ratio1.31.32.1-1.1-0.81.4
Condit. Reinf. active responses1.01.42.21.5-0.8-1.1
Condit. Reinf. inactive responses1.41.82.71.60.1-1.6
Condit. Reinf. lever presses0.10.20.3-0.00.6-0.4
Condit. Reinf. lever reinforcers received1.11.52.41.5-0.8-1.2
Pavlov. Cond. lever latency0.10.20.20.5-0.4-0.2
Pavlov. Cond. magazine entry latency1.01.11.6-1.30.41.2
Pavlov. Cond. change in total contacts0.00.10.2-0.10.4-0.1
Pavlov. Cond. index score1.11.42.2-1.50.61.2
Pavlov. Cond. latency score1.01.22.0-1.40.31.3
Pavlov. Cond. lever contacts0.40.50.9-0.81.00.2
Pavlov. Cond. magazine entry number0.81.01.51.2-0.2-1.2
Pavlov. Cond. intertrial magazine entries0.10.20.20.5-0.3-0.4
Pavlov. Cond. lever-magazine prob. diff.0.91.21.9-1.40.61.2
Pavlov. Cond. response bias0.50.61.1-0.81.10.3
Conditioned reinforcement - actives0.40.40.50.60.7-0.7
Conditioned reinforcement - inactives1.01.11.8-1.20.31.3
Conditioned locomotion1.41.63.9-1.02.00.1
Intermittent access intake day 1-15 change0.40.41.1-0.2-0.41.0
Intermittent access intake escalation0.50.51.4-0.40.11.2
Intermittent access intake escalation 21.81.82.1-1.21.41.3
Intermitt. access day 1 inactive lever presses2.83.14.12.0-1.9-1.1
Intermitt. access day 15 inactive lever presses2.32.54.2-1.8-0.22.0
Intermitt. access escalation Index1.11.01.4-1.1-0.61.2
Intermittent access day 1 total infusions0.40.41.0-0.41.0-0.3
Intermittent access day 15 total infusions0.60.61.4-0.61.20.5
Intermittent access terminal intake (last 3 days)1.92.14.2-1.22.00.7
Intermittent access total infusions1.31.43.0-1.01.70.5
Intermittent access day 1 locomotion0.10.10.1-0.30.3-0.1
Intermittent access day 15 total locomotion1.21.31.71.01.1-1.3
Intermittent access total locomotion0.40.51.2-0.31.10.0
Intermittent access standard deviation0.10.10.20.40.3-0.2
Cocaine induced anxiety1.82.13.2-1.80.11.8
Post-drug Anxiety0.40.50.6-0.80.70.6
Baseline Anxiety2.93.15.21.80.8-2.3
Lifetime Intake1.31.42.7-1.21.70.4
Incentive Sensitization - Responses1.11.11.4-1.11.20.8
Incentive Sensitization - Breakpoint1.21.21.5-1.21.20.8
Progressive ratio test 1 active lever presses2.82.96.6-1.52.60.1
Progressive ratio test 1 breakpoint2.52.65.8-1.42.40.1
Progressive ratio test 1 inactive lever presses0.10.10.20.3-0.1-0.5
Progressive ratio test 2 active lever presses2.12.35.8-1.02.4-0.0
Progressive ratio test 2 breakpoint1.21.43.5-0.71.9-0.2
Progressive ratio test 2 inactive lever presses0.50.61.3-0.61.20.3
Total sessions with >9 infusions0.70.81.6-1.30.20.8
Short access day 1 total inactive lever presses0.00.00.10.30.0-0.1
Short access day 10 total inactive lever presses1.51.73.11.4-1.8-0.3
Short access day 1 total infusions0.40.50.9-0.30.9-0.7
Short access day 10 total infusions0.40.40.9-0.41.0-0.2
Short access total infusions0.60.71.2-1.10.80.5
Short access day 1 locomotion0.70.71.8-0.21.3-0.6
Short access day 10 total locomotion0.10.10.30.20.2-0.6
Short access total locomotion0.20.20.4-0.60.50.1
Compulsive drug intake1.71.62.91.3-1.7-0.6
One hour access (0.3 mA shock)1.51.74.5-0.82.10.0
One hour access (shock baseline)3.33.89.0-1.53.00.3
Number of responses in last shaping day1.51.52.61.40.1-1.6
Context. condit. distance diff. score3.74.56.92.6-0.8-2.4
Locomotion velocity, session 11.21.32.01.4-0.9-1.0
Locomotion distance, session 12.43.14.92.2-0.9-1.9
Locomotion velocity, session 21.01.21.91.4-1.1-0.6
Locomotion distance, session 21.21.73.01.7-0.2-1.5
Locomotion velocity, session 31.61.83.01.7-0.4-1.5
Locomotion distance, session 32.83.04.92.2-1.2-1.7
Stereotopy head waving bouts, day 30.40.50.90.70.3-0.9
Stereotopy head waving duration, day 30.40.40.90.50.5-0.9
Locomotion velocity, session 70.91.01.91.00.3-1.4
Locomotion distance, session 70.30.40.80.50.4-0.9
Stereotopy head waving bouts, day 70.40.51.20.5-1.1-0.2
Stereotopy head waving duration, day 70.00.10.10.3-0.3-0.1
Locomotion velocity, session 84.65.58.83.0-1.1-2.5
Locomotion distance, session 84.77.011.23.3-1.3-2.8
Degree of sensitization distance1.51.62.2-1.51.21.0
Degree of sensitization stereotypy0.10.10.30.2-0.50.1
Condit. Reinf. active minus inactive responses0.10.10.1-0.20.30.3
Condit. Reinf. active-inactive response ratio0.40.40.6-0.50.80.6
Condit. Reinf. active responses0.10.10.20.4-0.0-0.1
Condit. Reinf. inactive responses0.30.40.70.7-0.8-0.3
Incentive salience index mean0.10.10.20.40.0-0.3
Condit. Reinf. lever presses0.10.20.30.4-0.5-0.3
Time in familiar zone, hab. session 11.71.62.51.4-0.4-1.6
Time in novel zone, hab. session 13.93.84.9-2.21.61.9
Total zone transitions, hab. session 13.04.26.32.50.5-2.5
Total locomotion distance, hab. session 12.84.07.11.91.2-2.7
Locomotion velocity, hab. session 13.14.57.82.30.6-2.8
Time in familiar zone, hab. session 20.50.51.0-0.71.00.0
Time in novel zone, hab. session 20.30.30.50.2-0.70.5
Total zone transitions, hab. session 20.30.30.70.8-0.4-0.4
Total locomotion distance, hab. session 20.30.40.60.70.3-0.8
Locomotion velocity, hab. session 20.81.11.71.20.3-1.3
Novel to familiar place preference ratio0.20.20.40.30.3-0.7
Novelty place preference0.20.20.40.10.5-0.6
Time in novel zone, NPP test0.30.30.50.20.7-0.7
Total zone transitions, NPP test1.21.72.91.3-1.7-0.5
Total locomotion distance, NPP test0.91.21.61.3-0.6-1.3
Locomotion velocity, NPP test1.11.62.11.4-1.1-1.2
Pavlov. Cond. lever latency0.60.81.2-1.1-0.01.1
Pavlov. Cond. magazine entry latency0.70.91.41.10.1-1.2
Pavlov. Cond. change in total contacts0.40.40.60.8-0.2-0.7
Pavlov. Cond. index score1.41.82.61.6-0.3-1.6
Pavlov. Cond. latency score0.91.21.81.3-0.3-1.3
Pavlov. Cond. lever contacts1.11.22.01.4-0.5-1.2
Pavlov. Cond. magazine entry number1.01.32.1-1.40.41.3
Pavlov. Cond. intertrial magazine entries0.91.11.71.20.2-1.3
Pavlov. Cond. lever-magazine prob. diff.1.61.93.01.7-0.3-1.7
Pavlov. Cond. response bias1.11.32.11.40.1-1.4
Bone: apparent density1.21.95.40.6-2.3-0.1
Bone surface0.81.42.5-0.8-1.61.0
Bone volume0.61.13.2-0.0-1.80.3
Bone: connectivity density0.91.43.40.8-1.8-0.5
Bone: cortical apparent density0.60.71.21.1-0.5-0.9
Bone: cortical area0.71.03.0-0.0-1.70.2
Bone: cortical porosity0.20.20.3-0.50.50.0
Bone: cortical porosity0.20.20.5-0.70.30.3
Bone: cortical thickness1.72.87.60.8-2.8-0.1
Bone: cortical thickness0.80.91.6-0.7-1.30.8
Bone: cortical tissue density0.50.61.11.0-0.4-0.8
Bone: elastic displacement1.41.64.40.2-2.10.6
Bone: elastic work1.62.15.4-0.2-2.30.9
Bone: endosteal estimation0.71.42.4-1.61.10.8
Bone: endosteal perimeter0.61.22.5-1.60.51.0
Bone: final force0.50.91.9-1.4-0.20.9
Bone: final moment0.50.92.0-1.40.00.8
Bone: marrow area0.61.22.2-1.51.00.8
Bone: maximum diameter0.71.41.6-1.3-0.91.3
Bone: maximum force0.40.71.7-1.3-0.40.6
Bone: maximum moment0.40.71.8-1.3-0.10.5
Bone: minimum diameter1.83.44.9-2.22.10.8
Bone: periosteal estimation0.30.71.2-1.1-0.40.8
Bone: periosteal perimeter0.10.20.3-0.6-0.50.2
Bone: post-yield work2.02.74.0-2.02.00.6
Bone: stiffness0.50.82.10.20.6-1.4
Bone: tissue strength0.40.40.80.10.9-0.7
Bone: trabecular number0.91.32.51.0-1.6-0.8
Bone: trabecular spacing0.20.20.40.10.6-0.4
Bone: trabecular thickness0.70.82.10.6-1.5-0.2
Bone: trabecular tissue density0.20.30.50.4-0.7-0.4
Breakpoint value in progressive ratio session0.20.20.3-0.6-0.10.4
Distance traveled before self-admin1.31.43.7-0.41.9-0.5
Distance traveled after self-admin1.92.15.20.02.3-1.0
Delta time in closed arm before/after self-admin0.10.10.10.2-0.2-0.4
Delta time in open arm before/after self-admin0.90.92.5-0.21.6-0.3
Diff in mean of infusions in LGA sessions1.31.52.6-1.3-0.41.6
Extinction: sum of active levers before priming0.80.82.1-0.11.4-0.5
Active lever presses in extinction session 61.01.01.4-1.20.81.0
Delta distance traveled before/after self-admin0.20.20.30.60.0-0.5
Delta ambulatory time before/after self-admin0.20.20.40.7-0.3-0.3
Time in closed arm before self-admin0.91.02.20.4-1.50.8
Time in closed arm after self-admin1.71.83.11.3-1.8-0.7
Time in open arm before self-admin0.20.20.5-0.70.20.2
Time in open arm after self-admin2.32.56.8-0.82.6-0.1
Sum of active levers in priming session hrs 5-60.30.30.7-0.30.8-0.4
Time to tail flick, vehicle, before self-admin0.60.61.2-0.81.10.4
Time to tail flick, vehicle, after self-admin2.12.33.41.8-0.5-1.8
Time to tail flick, test, before self-admin0.20.20.50.7-0.2-0.2
Time to tail flick, test, after self-admin0.40.41.0-0.41.0-0.1
Delta time to tail flick, vehicle, before/after SA1.61.62.41.5-1.0-1.1
Delta time to tail flick, test, before/after SA0.50.40.9-0.40.9-0.5
Ambulatory time before self-admin1.21.23.00.01.7-0.9
Ambulatory time after self-admin1.51.73.30.61.8-1.2
Total heroin consumption0.40.51.4-0.21.2-0.1
Area under the delay curve0.91.01.41.20.5-1.2
Delay disc. indifference point, 0s delay0.40.40.80.9-0.6-0.5
Delay disc. indifference point, 16s delay0.91.02.01.40.1-0.9
Delay disc. indifference point, 2s delay0.50.60.90.41.0-0.9
Delay disc. indifference point, 24s delay1.51.52.80.61.7-1.1
Delay disc. indifference point, 4s delay2.83.05.02.00.2-2.2
Delay disc. indifference point, 8s delay0.30.30.40.6-0.1-0.6
Delay discount exponential model param1.01.11.6-1.1-0.71.3
Delay discount hyperbolic model param1.51.62.5-1.3-0.71.6
Fecal boli incidents, locomotor time 10.50.61.3-1.10.30.6
Change in fecal boli incidents, locomotor task0.70.71.1-1.0-0.01.0
Time >=10cm from walls, locomotor time 11.21.21.9-1.4-0.11.3
Bouts of movement, locomotor time 10.10.10.4-0.30.6-0.0
Total resting periods, locomotor time 10.40.51.1-0.51.00.0
Rest time, locomotor task time 10.60.70.9-0.90.90.5
Distance moved, locomotor task time 10.00.00.0-0.10.20.0
Vertical activity count, locomotor time 10.40.40.60.70.4-0.7
Time >=10cm from walls, locomotor time 20.60.60.8-0.8-0.70.9
Bouts of movement, locomotor time 21.11.22.01.10.7-1.4
Total resting periods, locomotor time 20.70.81.10.80.8-1.0
Rest time, locomotor task time 21.41.74.4-0.72.1-0.3
Distance moved, locomotor task time 20.91.02.40.2-1.50.7
Vertical activity count, locomotor time 20.50.61.00.9-1.0-0.1
Weight adjusted by age0.10.10.3-0.5-0.20.3
Seeking ratio, delayed vs. immediate footshock0.30.40.50.40.7-0.7
Locomotion in novel chamber1.11.31.91.40.3-1.4
Locomotion in novel chamber post-restriction0.20.20.30.50.5-0.4
Progressive ratio0.10.10.30.2-0.6-0.1
Food seeking constrained by brief footshock0.30.30.80.2-0.90.4
Seeking ratio, punishment vs. effort0.10.10.1-0.30.30.2
Run reversals in cocaine runway, females0.30.30.40.5-0.6-0.4
Run reversals in cocaine runway, males1.71.72.6-1.1-1.11.6
Latency to leave start box in cocaine runway0.00.00.10.10.1-0.3
Latency to leave start box in cocaine runway, F0.40.40.80.40.7-0.9
Latency to leave start box in cocaine runway, M1.51.52.7-1.1-0.71.6
Cd content in liver2.22.43.8-2.00.21.8
Co content in liver0.40.51.30.11.1-0.5
Cu content in liver0.60.71.60.70.3-1.3
Fe content in liver0.60.72.00.5-1.4-0.0
K content in liver4.04.07.41.91.1-2.7
Mg content in liver2.42.54.00.61.8-2.0
Mn content in liver1.61.82.41.5-1.6-0.9
Na content in liver5.55.911.32.40.9-3.4
Rb content in liver0.30.40.5-0.70.00.7
Se content in liver1.72.03.41.60.3-1.8
Sr content in liver1.51.32.1-1.1-0.91.4
Zn content in liver1.41.52.51.40.0-1.6