Hsd17b6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	ENSRNOG00000002597	0.77	0.01	0.0e+00	0.61	0.59	0.63	0.64	1.7e-86	3.0e-81	1.2e-89	3.7e-93
2	Liver	intron excision ratio	chr7:423005:425745	0.09	0.07	8.2e-06	0.06	0.04	0.05	0.05	8.1e-07	1.2e-05	1.9e-06	1.3e-06
3	Liver	intron excision ratio	chr7:425908:429139	0.05	0.04	6.1e-04	0.03	0.03	0.03	0.03	3.5e-04	5.3e-04	1.9e-04	3.7e-04
4	Liver	intron excision ratio	chr7:432171:441123	0.51	0.1	0.0e+00	0.36	0.38	0.39	0.39	2.6e-42	5.4e-44	1.8e-46	4.9e-46
5	Liver	intron excision ratio	chr7:432171:441762	0.51	0.09	0.0e+00	0.43	0.42	0.43	0.44	7.1e-52	4.4e-51	1.3e-52	5.5e-53
6	Liver	mRNA stability	ENSRNOG00000002597	0.15	0.08	0.0e+00	0.12	0.14	0.14	0.14	2.9e-13	3.0e-15	3.6e-15	2.9e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	8.0	25.8	31.6	5.0	-5.6	4.3	4.9	-5.3	-5.3
BMI without tail	0.9	1.9	3.7	1.5	-1.3	0.7	1.2	-1.4	-1.9
Body weight	1.1	4.6	5.7	2.1	-2.2	1.7	2.0	-2.3	-2.4
Epididymis fat weight	0.1	0.2	0.4	-0.6	0.2	-0.3	-0.5	0.4	0.5
Glucose	1.6	2.4	3.1	1.7	-1.5	1.2	1.5	-1.6	-1.8
Heart weight	0.1	0.1	0.3	0.1	0.4	-0.6	-0.2	0.0	-0.3
Left kidney weight	0.2	0.5	1.1	1.0	-0.0	0.9	0.8	-0.7	-0.3
Right kidney weight	0.1	0.3	0.6	-0.3	0.8	-0.2	-0.4	0.6	0.7
Tail length	6.1	18.5	23.1	-4.2	4.8	-4.1	-4.3	4.4	3.9
Length with tail	1.8	6.8	9.3	-2.5	3.0	-2.2	-2.5	2.6	2.7
Length without tail	0.3	0.7	1.2	0.8	-0.7	1.1	1.0	-0.9	-0.3
Liver weight, left	1.1	1.9	3.1	1.4	-1.5	0.8	1.2	-1.4	-1.8
Liver weight, right	0.6	1.0	1.7	1.2	-0.8	0.6	0.8	-1.0	-1.3
Parametrial fat weight	0.1	0.1	0.3	-0.5	0.2	-0.3	-0.3	0.2	0.2
Retroperitoneal fat weight	1.8	5.8	9.2	2.5	-2.4	1.6	2.2	-2.5	-3.0
Intraocular pressure	0.8	1.1	1.7	-1.2	1.0	-1.3	-1.1	1.0	0.8
Extensor digitorum longus weight	3.9	15.5	25.0	4.1	-4.2	2.4	3.5	-4.0	-5.0
Soleus weight	5.3	15.6	20.5	4.2	-4.1	2.9	3.8	-4.0	-4.5
Tibialis anterior weight	1.0	3.3	4.8	2.0	-1.7	1.2	1.7	-1.9	-2.2
Tibia length	1.3	3.7	4.2	-2.1	2.0	-1.7	-1.9	2.1	1.8
Number of licking bursts	2.1	2.5	4.4	1.5	-1.8	0.9	1.3	-1.6	-2.1
Food consumed during 24 hour testing period	0.5	0.6	0.7	0.7	-0.8	0.7	0.8	-0.8	-0.7
Times rat made contact with spout	0.8	0.9	1.4	0.8	-1.1	0.5	0.8	-1.0	-1.2
Mean time between licks in bursts	0.8	1.2	1.4	-1.2	1.0	-1.1	-1.1	1.1	1.0
Mean num. licks in bursts	0.5	0.6	1.1	-0.7	0.9	-0.5	-0.6	0.8	1.0
Std. dev. time between licks in bursts	0.1	0.1	0.5	-0.2	0.3	0.3	-0.0	0.2	0.7
Water consumed over 24 hours	1.8	2.2	2.9	1.5	-1.4	1.7	1.7	-1.5	-0.9
Indifference point 0 sec	5.0	8.1	9.8	2.8	-3.1	2.7	2.9	-2.9	-2.6
Indifference point AUC	0.7	0.8	1.0	-0.8	1.0	-0.9	-1.0	1.0	0.9
Indifference point function ln k	0.2	0.3	0.4	0.5	-0.5	0.4	0.6	-0.6	-0.6
Indifference point function log k	0.2	0.3	0.4	0.5	-0.5	0.4	0.6	-0.6	-0.6
Delay discounting total patch changes 0 sec	4.6	7.5	9.5	2.7	-3.1	2.6	2.8	-2.8	-2.5
Delay discounting total patch changes 12 sec	1.3	1.8	2.7	1.3	-1.6	0.9	1.2	-1.3	-1.6
Delay discounting total patch changes 18 sec	0.1	0.1	0.1	0.3	-0.3	0.3	0.2	-0.2	-0.2
Delay discounting total patch changes 24 sec	0.6	0.8	0.9	1.0	-0.9	0.9	0.9	-0.8	-0.7
Delay discounting total patch changes 6 sec	2.3	3.5	4.4	1.8	-2.1	1.7	1.8	-1.9	-1.9
Delay discounting time to switch 0 sec	0.3	0.4	0.6	0.7	-0.5	0.8	0.7	-0.7	-0.4
Delay discounting water rate 0 sec	0.3	0.5	1.0	0.6	-0.8	0.1	0.5	-0.6	-1.0
Delay discounting water rate 12 sec	0.4	0.6	1.4	0.7	-0.9	0.1	0.5	-0.7	-1.2
Delay discounting water rate 18 sec	0.8	1.0	2.5	-1.0	0.6	-1.6	-1.2	0.9	-0.2
Delay discounting water rate 24 sec	0.4	0.6	2.1	0.2	-0.9	-0.6	-0.1	-0.4	-1.4
Delay discounting water rate 6 sec	1.0	1.5	2.8	-1.2	1.1	-1.7	-1.4	1.2	0.5
Locomotor activity	2.7	4.2	6.5	-2.1	2.5	-1.3	-1.7	2.0	2.5
Locomotor testing distance	0.9	1.4	2.4	-1.2	1.4	-0.7	-0.9	1.1	1.6
Locomotor testing rearing	0.1	0.1	0.2	-0.3	0.4	-0.5	-0.3	0.2	0.1
Light reinforcement 1	2.6	4.8	6.9	-2.2	2.3	-1.5	-2.0	2.2	2.6
Light reinforcement 2	0.7	0.9	1.4	-1.1	0.8	-0.5	-0.8	1.0	1.2
Reaction time number correct	0.5	0.7	1.3	0.6	-1.1	0.3	0.6	-0.8	-1.2
Reaction time mean minus median	1.7	2.2	3.2	-1.5	1.8	-1.2	-1.4	1.5	1.4
Reaction time mean minus median AUC	0.8	1.0	2.3	-0.9	1.3	-0.2	-0.6	0.9	1.5
Reaction time num false alarms	0.3	0.4	0.9	0.7	-0.6	0.2	0.5	-0.5	-0.9
Reaction time num false alarms AUC	0.2	0.3	1.0	0.6	-0.5	-0.0	0.3	-0.5	-1.0
Reaction time trials correct on left	0.5	0.7	1.3	0.6	-1.1	0.3	0.6	-0.8	-1.2
Reaction time trials on left	0.5	0.7	1.3	0.6	-1.2	0.4	0.6	-0.8	-1.1
Reaction time mean	0.6	0.8	1.8	-0.8	1.1	-0.3	-0.7	0.9	1.3
Reaction time mean AUC	0.2	0.2	0.7	-0.3	0.6	0.1	-0.2	0.4	0.8
Median of all reaction times	0.2	0.3	0.8	-0.4	0.6	0.0	-0.3	0.5	0.9
Reaction time omissions	0.1	0.1	0.2	0.3	-0.2	0.4	0.3	-0.2	-0.0
Reaction time false alarm rate	0.0	0.1	0.2	0.4	-0.1	0.1	0.2	-0.2	-0.4
Reaction time premature initiation rate	2.4	3.3	4.1	-1.8	1.9	-2.0	-1.9	1.8	1.4
Reaction time premature initiations	1.5	2.1	3.5	-1.5	1.3	-1.9	-1.6	1.4	0.8
Std. dev. reaction times	0.6	0.8	1.3	-0.8	1.1	-0.5	-0.7	0.9	1.1
Reaction time trials completed	0.5	0.7	1.3	0.6	-1.2	0.4	0.6	-0.8	-1.1
Reaction time trials AUC	0.5	0.7	1.4	0.6	-1.2	0.3	0.6	-0.8	-1.2
Social response proportion	0.7	0.8	1.4	-0.8	1.0	-0.5	-0.8	0.9	1.2
Social responses	7.3	9.4	14.0	-3.1	3.3	-2.1	-2.8	3.1	3.7
Social time	0.5	0.6	1.7	0.9	-0.6	0.2	0.6	-0.7	-1.3
Conditioned locomotion	0.3	0.3	1.1	0.3	-0.7	-0.2	0.1	-0.4	-1.1
Cocaine response after cond. corrected	1.0	1.1	3.0	1.0	-1.1	0.1	0.6	-0.9	-1.7
Cocaine response after cond. not corrected	1.0	1.1	3.1	1.0	-1.1	0.0	0.6	-0.9	-1.7
Cocaine response before conditioning	0.3	0.4	0.7	-0.6	0.8	-0.3	-0.5	0.6	0.9
Saline control response	0.2	0.2	0.5	0.5	-0.4	0.1	0.3	-0.4	-0.7
Condit. Reinf. active minus inactive responses	2.4	3.0	3.4	-1.8	1.7	-1.8	-1.8	1.8	1.5
Condit. Reinf. active-inactive response ratio	1.6	1.6	2.7	-1.3	1.1	-1.6	-1.5	1.3	0.6
Condit. Reinf. active responses	1.1	1.5	1.8	-1.3	1.3	-1.0	-1.2	1.3	1.4
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.3	0.3	0.2	-0.0	0.2	0.6
Condit. Reinf. lever presses	2.9	4.0	4.9	-2.2	1.9	-1.8	-2.0	2.0	1.9
Condit. Reinf. lever reinforcers received	1.0	1.4	1.7	-1.3	1.2	-1.1	-1.2	1.2	1.2
Pavlov. Cond. lever latency	1.5	2.0	2.5	1.5	-1.5	1.1	1.3	-1.5	-1.6
Pavlov. Cond. magazine entry latency	2.1	2.4	3.1	-1.6	1.7	-1.2	-1.5	1.5	1.8
Pavlov. Cond. change in total contacts	0.7	1.0	1.2	-1.1	1.1	-0.8	-1.0	1.0	1.0
Pavlov. Cond. index score	1.9	2.5	2.9	-1.7	1.7	-1.3	-1.5	1.6	1.7
Pavlov. Cond. latency score	1.9	2.4	3.2	-1.6	1.7	-1.2	-1.5	1.5	1.8
Pavlov. Cond. lever contacts	1.5	2.0	2.3	-1.5	1.4	-1.2	-1.4	1.5	1.4
Pavlov. Cond. magazine entry number	1.7	2.1	2.9	1.6	-1.5	1.0	1.4	-1.4	-1.7
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.3	0.7	-0.5	0.0	0.4	-0.6	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	3.0	-1.6	1.7	-1.2	-1.5	1.6	1.7
Pavlov. Cond. response bias	2.3	3.2	3.6	-1.9	1.8	-1.6	-1.8	1.8	1.8
Conditioned reinforcement - actives	0.2	0.2	0.3	0.4	-0.3	0.6	0.5	-0.4	-0.1
Conditioned reinforcement - inactives	0.6	0.7	2.1	0.9	-0.8	0.1	0.5	-0.8	-1.4
Conditioned locomotion	1.2	1.4	2.6	-1.4	1.1	-0.6	-1.1	1.3	1.6
Intermittent access intake day 1-15 change	0.3	0.3	0.4	-0.4	0.6	-0.6	-0.6	0.6	0.3
Intermittent access intake escalation	0.7	0.7	1.4	-0.7	0.7	-1.2	-1.0	0.8	0.1
Intermittent access intake escalation 2	1.4	1.3	1.9	-1.1	1.1	-1.4	-1.3	1.2	0.6
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.3	-0.6	0.7	-1.1	-0.9	0.7	-0.0
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.5	-1.2	0.9	-1.1	-1.2	1.1	0.8
Intermitt. access escalation Index	0.3	0.3	0.6	0.6	-0.0	0.8	0.7	-0.5	0.1
Intermittent access day 1 total infusions	0.8	1.0	1.5	0.8	-1.2	1.0	1.0	-1.0	-0.7
Intermittent access day 15 total infusions	0.2	0.3	0.6	0.4	-0.8	0.4	0.5	-0.5	-0.5
Intermittent access terminal intake (last 3 days)	0.7	0.7	1.0	0.8	-1.0	0.9	0.9	-0.8	-0.5
Intermittent access total infusions	0.7	0.8	1.3	0.8	-1.1	0.8	0.9	-0.9	-0.8
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	0.1	-0.1
Intermittent access day 15 total locomotion	0.3	0.3	0.5	-0.6	0.5	-0.6	-0.7	0.7	0.5
Intermittent access total locomotion	0.1	0.1	0.2	-0.4	0.2	-0.2	-0.4	0.5	0.5
Intermittent access standard deviation	0.2	0.2	0.3	-0.4	0.2	-0.5	-0.5	0.5	0.2
Cocaine induced anxiety	0.7	0.8	2.2	-0.8	0.9	-0.1	-0.5	0.8	1.5
Post-drug Anxiety	0.2	0.3	0.8	0.2	0.1	0.9	0.5	-0.2	0.7
Baseline Anxiety	0.0	0.1	0.1	-0.1	0.2	-0.4	-0.3	0.2	-0.1
Lifetime Intake	2.1	2.3	3.2	1.4	-1.8	1.5	1.6	-1.5	-1.2
Incentive Sensitization - Responses	0.1	0.1	0.1	-0.2	0.3	-0.2	-0.2	0.2	0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.1	-0.2	0.4	-0.1	-0.2	0.2	0.4
Progressive ratio test 1 active lever presses	1.2	1.2	1.9	1.2	-1.0	0.7	1.0	-1.2	-1.4
Progressive ratio test 1 breakpoint	1.4	1.4	2.0	1.3	-1.0	0.8	1.1	-1.3	-1.4
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	0.4	0.0	0.2	0.3	-0.3	-0.2
Progressive ratio test 2 active lever presses	0.6	0.7	0.9	1.0	-0.8	0.6	0.8	-0.9	-0.9
Progressive ratio test 2 breakpoint	0.4	0.5	0.7	0.8	-0.5	0.7	0.8	-0.7	-0.4
Progressive ratio test 2 inactive lever presses	0.9	1.0	1.3	1.0	-1.1	1.1	1.1	-1.1	-0.7
Total sessions with >9 infusions	2.1	2.3	3.8	1.4	-1.6	1.9	1.7	-1.5	-0.6
Short access day 1 total inactive lever presses	0.1	0.1	0.3	0.3	-0.5	0.5	0.4	-0.3	-0.2
Short access day 10 total inactive lever presses	0.2	0.2	0.6	-0.2	0.5	-0.8	-0.6	0.4	-0.2
Short access day 1 total infusions	3.2	3.4	4.6	1.9	-1.8	2.2	2.0	-1.8	-1.1
Short access day 10 total infusions	1.6	1.8	2.6	1.2	-1.6	1.3	1.4	-1.4	-1.1
Short access total infusions	4.0	4.5	5.3	2.1	-2.2	2.3	2.3	-2.1	-1.5
Short access day 1 locomotion	0.0	0.0	0.1	0.2	0.0	0.3	0.2	-0.1	0.1
Short access day 10 total locomotion	1.9	2.1	2.5	-1.5	1.4	-1.5	-1.6	1.6	1.2
Short access total locomotion	0.0	0.0	0.1	-0.1	0.2	-0.0	-0.2	0.3	0.3
Compulsive drug intake	0.3	0.3	0.5	0.6	-0.4	0.4	0.7	-0.7	-0.4
One hour access (0.3 mA shock)	0.8	0.9	1.6	0.8	-1.3	0.9	0.9	-1.0	-0.7
One hour access (shock baseline)	0.1	0.2	0.7	0.1	-0.8	0.2	0.2	-0.2	-0.4
Number of responses in last shaping day	0.5	0.5	0.6	-0.7	0.7	-0.6	-0.7	0.8	0.8
Context. condit. distance diff. score	0.1	0.1	0.3	0.4	-0.3	0.1	0.2	-0.3	-0.6
Locomotion velocity, session 1	0.4	0.5	1.0	0.7	-0.4	1.0	0.8	-0.6	-0.1
Locomotion distance, session 1	0.2	0.3	0.9	0.3	-0.1	0.9	0.6	-0.3	0.5
Locomotion velocity, session 2	0.3	0.4	1.4	-0.3	0.8	0.4	-0.0	0.4	1.2
Locomotion distance, session 2	1.1	1.5	4.4	-1.1	1.4	-0.1	-0.6	1.1	2.1
Locomotion velocity, session 3	4.8	5.6	6.5	-2.4	2.5	-1.9	-2.3	2.4	2.5
Locomotion distance, session 3	0.2	0.2	0.2	-0.4	0.5	-0.4	-0.4	0.4	0.3
Stereotopy head waving bouts, day 3	4.2	5.0	7.6	-2.3	2.3	-1.5	-2.1	2.4	2.8
Stereotopy head waving duration, day 3	2.3	2.8	4.5	-1.8	1.6	-1.1	-1.5	1.7	2.1
Locomotion velocity, session 7	0.0	0.0	0.1	0.1	-0.1	0.3	0.2	-0.1	0.2
Locomotion distance, session 7	0.0	0.0	0.1	-0.0	-0.3	-0.2	0.0	-0.1	-0.3
Stereotopy head waving bouts, day 7	0.5	0.6	1.2	-0.5	1.0	-0.2	-0.5	0.8	1.1
Stereotopy head waving duration, day 7	0.3	0.4	1.1	-0.3	0.9	0.0	-0.4	0.7	1.0
Locomotion velocity, session 8	0.4	0.5	1.8	-0.5	0.8	0.3	-0.2	0.6	1.4
Locomotion distance, session 8	0.2	0.2	0.6	-0.5	0.5	-0.1	-0.4	0.5	0.8
Degree of sensitization distance	0.7	0.7	1.0	0.8	-1.0	0.8	0.8	-0.9	-0.8
Degree of sensitization stereotypy	0.1	0.1	0.3	0.5	0.0	0.5	0.4	-0.2	-0.1
Condit. Reinf. active minus inactive responses	1.5	1.7	2.2	-1.3	1.4	-1.0	-1.2	1.3	1.5
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	-0.6	0.7	-0.7	-0.7	0.6	0.4
Condit. Reinf. active responses	1.7	2.0	3.6	-1.4	1.6	-0.7	-1.2	1.4	1.9
Condit. Reinf. inactive responses	0.7	0.8	2.1	-0.8	1.0	-0.1	-0.6	0.8	1.4
Incentive salience index mean	0.7	0.8	1.6	-0.8	1.0	-0.3	-0.7	0.9	1.3
Condit. Reinf. lever presses	0.2	0.2	0.6	0.2	0.2	0.8	0.4	-0.0	0.7
Time in familiar zone, hab. session 1	5.4	5.1	6.3	-2.5	2.3	-2.0	-2.2	2.2	2.3
Time in novel zone, hab. session 1	5.0	4.9	5.9	2.4	-2.1	2.3	2.3	-2.2	-1.9
Total zone transitions, hab. session 1	0.2	0.2	0.8	-0.2	0.4	0.6	0.2	0.1	0.9
Total locomotion distance, hab. session 1	0.5	0.7	2.7	-0.6	0.9	0.5	-0.2	0.7	1.6
Locomotion velocity, hab. session 1	0.7	0.9	2.9	-0.8	1.1	0.1	-0.5	0.9	1.7
Time in familiar zone, hab. session 2	5.4	5.6	6.7	-2.6	2.3	-2.3	-2.4	2.4	2.3
Time in novel zone, hab. session 2	7.0	7.0	7.7	2.8	-2.7	2.7	2.7	-2.7	-2.4
Total zone transitions, hab. session 2	1.5	2.0	3.5	1.4	-1.2	1.9	1.7	-1.4	-0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.5	-0.1	0.2	0.5	0.2	0.1	0.7
Locomotion velocity, hab. session 2	0.2	0.2	0.7	-0.0	0.2	0.7	0.3	0.1	0.8
Novel to familiar place preference ratio	4.2	4.4	5.2	2.2	-2.0	2.3	2.3	-2.1	-1.7
Novelty place preference	3.1	3.2	4.1	1.9	-1.7	2.0	2.0	-1.8	-1.3
Time in novel zone, NPP test	3.8	4.0	4.7	2.1	-2.0	2.2	2.1	-2.0	-1.6
Total zone transitions, NPP test	0.6	0.9	1.5	0.8	-0.9	1.2	1.1	-1.0	-0.5
Total locomotion distance, NPP test	0.4	0.5	1.3	0.6	-0.6	1.1	0.9	-0.7	-0.0
Locomotion velocity, NPP test	0.1	0.2	0.6	0.3	-0.2	0.8	0.5	-0.3	0.3
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.4	0.4	-0.9	-0.6	0.3	-0.3
Pavlov. Cond. magazine entry latency	1.4	1.8	2.1	-1.4	1.3	-1.1	-1.4	1.4	1.4
Pavlov. Cond. change in total contacts	0.4	0.4	0.5	0.6	-0.7	0.7	0.6	-0.6	-0.5
Pavlov. Cond. index score	0.1	0.2	0.6	-0.3	0.3	0.2	-0.2	0.4	0.8
Pavlov. Cond. latency score	0.1	0.2	0.7	-0.2	0.3	0.4	-0.0	0.3	0.8
Pavlov. Cond. lever contacts	0.4	0.5	1.3	0.6	-0.5	1.1	0.8	-0.5	0.2
Pavlov. Cond. magazine entry number	0.4	0.5	0.7	0.7	-0.6	0.5	0.7	-0.8	-0.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	-0.6	0.8	-1.1	-0.8	0.6	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.8	-0.4	0.4	0.1	-0.3	0.4	0.9
Pavlov. Cond. response bias	0.5	0.6	0.9	-0.8	0.7	-0.4	-0.7	0.8	1.0
Bone: apparent density	0.8	1.3	3.1	1.2	-0.6	1.8	1.4	-1.0	0.1
Bone surface	1.0	1.8	5.1	1.3	-0.5	2.3	1.6	-1.0	0.5
Bone volume	1.4	2.4	6.1	1.6	-0.7	2.5	1.9	-1.3	0.3
Bone: connectivity density	0.4	0.6	1.6	0.8	-0.4	1.3	1.0	-0.7	0.1
Bone: cortical apparent density	1.6	2.1	2.9	1.4	-1.7	1.2	1.4	-1.4	-1.5
Bone: cortical area	2.4	3.7	5.2	1.9	-1.8	2.3	2.1	-2.0	-1.2
Bone: cortical porosity	0.2	0.2	0.5	0.4	-0.3	0.7	0.6	-0.5	0.1
Bone: cortical porosity	1.0	1.0	1.8	0.9	-0.9	1.3	1.2	-1.1	-0.3
Bone: cortical thickness	2.5	4.1	4.8	1.9	-2.2	2.1	2.1	-2.1	-1.6
Bone: cortical thickness	0.7	0.8	1.2	0.7	-1.1	0.6	0.9	-1.0	-1.0
Bone: cortical tissue density	1.1	1.5	2.1	1.2	-1.4	0.9	1.1	-1.2	-1.3
Bone: elastic displacement	0.0	0.0	0.0	0.1	-0.1	0.2	0.1	-0.0	0.0
Bone: elastic work	1.2	1.6	2.0	1.2	-1.3	1.4	1.4	-1.3	-0.8
Bone: endosteal estimation	0.9	1.8	2.7	1.6	-1.1	1.4	1.4	-1.4	-1.3
Bone: endosteal perimeter	0.1	0.2	0.7	0.3	-0.0	0.8	0.4	-0.3	0.5
Bone: final force	3.9	6.4	7.4	2.6	-2.5	2.6	2.7	-2.7	-2.0
Bone: final moment	3.8	6.2	7.2	2.5	-2.4	2.6	2.7	-2.7	-2.0
Bone: marrow area	0.7	1.6	2.3	1.5	-1.0	1.3	1.3	-1.3	-1.2
Bone: maximum diameter	0.1	0.2	0.7	0.2	0.1	0.8	0.4	-0.2	0.6
Bone: maximum force	4.1	7.1	8.3	2.7	-2.7	2.7	2.8	-2.9	-2.2
Bone: maximum moment	4.1	7.1	8.2	2.7	-2.6	2.7	2.8	-2.9	-2.2
Bone: minimum diameter	0.8	1.4	2.2	1.3	-1.0	1.5	1.3	-1.2	-0.7
Bone: periosteal estimation	2.1	4.3	5.6	2.2	-1.8	2.4	2.2	-2.1	-1.5
Bone: periosteal perimeter	0.7	1.2	2.7	1.0	-0.9	1.6	1.3	-1.1	-0.1
Bone: post-yield work	0.2	0.3	0.6	0.7	-0.4	0.3	0.5	-0.6	-0.7
Bone: stiffness	5.5	8.7	9.8	3.0	-3.0	2.8	3.0	-3.1	-2.8
Bone: tissue strength	5.4	5.2	6.0	2.3	-2.5	2.1	2.3	-2.3	-2.2
Bone: trabecular number	0.2	0.3	1.3	-0.2	0.6	0.5	0.1	0.3	1.1
Bone: trabecular spacing	0.5	0.6	1.8	-0.6	0.1	-1.4	-0.9	0.5	-0.7
Bone: trabecular thickness	2.4	2.9	6.5	1.7	-1.1	2.6	2.1	-1.5	-0.1
Bone: trabecular tissue density	4.7	6.5	10.0	2.5	-2.9	1.7	2.3	-2.6	-3.2
Breakpoint value in progressive ratio session	2.4	2.7	3.2	-1.7	1.8	-1.5	-1.6	1.6	1.6
Distance traveled before self-admin	0.5	0.6	1.3	-0.9	0.6	-0.3	-0.6	0.8	1.1
Distance traveled after self-admin	0.1	0.1	0.3	-0.3	-0.1	0.3	0.0	0.1	0.5
Delta time in closed arm before/after self-admin	0.3	0.3	1.1	0.0	-0.4	-0.8	-0.3	-0.0	-1.0
Delta time in open arm before/after self-admin	1.1	1.0	1.1	1.1	-0.9	0.9	1.0	-1.1	-1.0
Diff in mean of infusions in LGA sessions	2.0	2.2	2.6	-1.6	1.5	-1.2	-1.5	1.5	1.6
Extinction: sum of active levers before priming	5.1	5.2	5.8	-2.4	2.3	-2.4	-2.4	2.3	1.8
Active lever presses in extinction session 6	0.9	0.9	1.7	-1.1	0.8	-0.5	-0.8	1.0	1.3
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.3	-0.2	0.3	0.3	-0.3	-0.2
Delta ambulatory time before/after self-admin	0.2	0.3	0.5	0.5	-0.4	0.7	0.6	-0.5	-0.2
Time in closed arm before self-admin	0.4	0.5	0.8	0.9	-0.3	0.9	0.9	-0.8	-0.2
Time in closed arm after self-admin	0.5	0.5	0.6	0.7	-0.8	0.6	0.7	-0.7	-0.7
Time in open arm before self-admin	0.2	0.2	0.4	-0.6	0.1	-0.4	-0.5	0.5	0.4
Time in open arm after self-admin	0.7	0.7	1.2	0.8	-1.1	0.6	0.7	-0.8	-1.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.7	0.3	-0.3	-0.5	0.5	0.6
Time to tail flick, vehicle, before self-admin	0.3	0.4	1.4	-0.2	0.6	0.5	0.0	0.3	1.2
Time to tail flick, vehicle, after self-admin	1.0	1.0	1.8	-1.0	1.1	-1.3	-1.1	0.9	0.5
Time to tail flick, test, before self-admin	0.4	0.4	1.0	-0.4	1.0	-0.1	-0.3	0.6	1.0
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.2	-0.2	0.7	0.5	-0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.1	-0.1	-0.8	-0.3	-0.0	-0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.6	0.2	-0.5	-0.5	0.4	0.3
Ambulatory time before self-admin	0.1	0.1	0.3	-0.5	0.2	-0.1	-0.2	0.2	0.6
Ambulatory time after self-admin	0.1	0.1	0.2	-0.1	-0.2	0.4	0.3	-0.2	0.2
Total heroin consumption	1.7	2.0	3.5	-1.6	1.5	-0.9	-1.2	1.4	1.9
Area under the delay curve	0.1	0.1	0.1	0.3	-0.1	0.3	0.3	-0.3	-0.0
Delay disc. indifference point, 0s delay	3.1	3.3	4.9	1.7	-1.7	2.2	2.1	-1.9	-1.0
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	-0.4	0.5	-0.3	-0.3	0.4	0.5
Delay disc. indifference point, 2s delay	0.4	0.5	0.8	0.7	-0.6	0.9	0.7	-0.7	-0.4
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.5	-0.6	0.6	0.6	-0.6	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.5	-0.2	0.3	0.3	0.0	0.2	0.7
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.0	-0.0	-0.3	-0.0	-0.1	-0.3
Delay discount exponential model param	0.0	0.0	0.0	-0.2	-0.0	-0.2	-0.2	0.2	-0.1
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.4	0.4	0.1
Fecal boli incidents, locomotor time 1	0.2	0.2	0.7	0.3	-0.2	-0.4	-0.0	-0.2	-0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	-0.2	0.2	0.6	0.2	-0.0	0.8
Time >=10cm from walls, locomotor time 1	1.5	1.5	2.2	1.2	-1.2	1.5	1.3	-1.2	-0.7
Bouts of movement, locomotor time 1	0.4	0.4	0.5	-0.7	0.7	-0.7	-0.7	0.7	0.7
Total resting periods, locomotor time 1	1.0	1.1	1.3	-1.0	1.2	-0.9	-1.0	1.1	1.1
Rest time, locomotor task time 1	0.3	0.3	0.6	-0.5	0.5	-0.2	-0.4	0.5	0.8
Distance moved, locomotor task time 1	1.4	1.5	2.1	1.2	-1.1	1.5	1.4	-1.3	-0.8
Vertical activity count, locomotor time 1	1.2	1.2	1.6	1.0	-1.2	0.8	1.1	-1.2	-1.3
Time >=10cm from walls, locomotor time 2	0.7	0.7	1.5	0.9	-0.9	0.4	0.6	-0.8	-1.2
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.1	0.4	0.3	0.1	0.1	0.6
Total resting periods, locomotor time 2	0.1	0.1	0.3	0.0	0.3	0.4	0.3	-0.1	0.5
Rest time, locomotor task time 2	0.1	0.1	0.3	0.2	-0.1	0.5	0.3	-0.1	0.3
Distance moved, locomotor task time 2	0.1	0.1	0.3	-0.2	0.1	-0.5	-0.3	0.1	-0.3
Vertical activity count, locomotor time 2	0.5	0.6	1.8	0.6	-0.7	-0.1	0.4	-0.7	-1.3
Weight adjusted by age	0.1	0.1	0.2	-0.2	0.0	-0.4	-0.3	0.3	-0.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.4	-0.7	0.6	-0.0	-0.4	0.7	1.2
Locomotion in novel chamber	0.3	0.4	0.5	0.7	-0.6	0.5	0.6	-0.7	-0.6
Locomotion in novel chamber post-restriction	3.0	3.5	4.6	-2.0	1.9	-1.4	-1.8	1.9	2.1
Progressive ratio	0.8	0.9	1.7	1.0	-1.0	0.5	0.8	-1.0	-1.3
Food seeking constrained by brief footshock	1.5	1.8	2.7	-1.5	1.2	-1.0	-1.3	1.3	1.6
Seeking ratio, punishment vs. effort	2.0	2.5	3.6	-1.7	1.5	-1.1	-1.5	1.6	1.9
Run reversals in cocaine runway, females	0.9	0.9	2.3	-1.1	0.7	-0.2	-0.7	0.9	1.5
Run reversals in cocaine runway, males	1.4	1.3	2.5	-1.0	1.3	-0.7	-1.0	1.2	1.6
Latency to leave start box in cocaine runway	0.6	0.6	1.4	0.8	-0.5	1.2	1.0	-0.8	-0.1
Latency to leave start box in cocaine runway, F	1.3	1.5	3.1	1.3	-0.9	1.8	1.4	-1.1	-0.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.5	0.4	-0.6	-0.4	0.3	-0.1
Cd content in liver	0.4	0.5	0.6	0.6	-0.7	0.6	0.7	-0.8	-0.8
Co content in liver	1.4	1.6	1.9	-1.4	1.2	-1.2	-1.3	1.4	1.1
Cu content in liver	2.9	3.5	5.3	1.7	-1.8	2.3	2.1	-1.9	-1.2
Fe content in liver	0.3	0.3	0.7	0.5	-0.6	0.1	0.4	-0.5	-0.9
K content in liver	0.1	0.1	0.5	-0.3	0.5	0.2	-0.0	0.2	0.7
Mg content in liver	0.1	0.1	0.3	-0.0	0.2	0.5	0.2	0.0	0.6
Mn content in liver	0.5	0.6	2.0	0.5	-0.1	1.4	0.8	-0.4	0.7
Na content in liver	0.3	0.3	0.6	0.5	-0.6	0.8	0.7	-0.6	-0.1
Rb content in liver	1.9	2.4	3.8	1.4	-1.6	1.9	1.7	-1.5	-0.9
Se content in liver	0.0	0.0	0.0	-0.1	0.1	0.2	0.1	0.0	0.2
Sr content in liver	0.8	0.8	1.6	-0.7	0.7	-1.3	-1.1	0.8	0.3
Zn content in liver	3.9	4.2	6.0	-2.1	2.0	-2.4	-2.3	2.1	1.3