Hub : Genes

Ugt2b10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative polyA ENSRNOT00000089471 0.03 0.02 7.6e-03 -0 0.01 -0 -0 9.7e-01 4.1e-02 9.3e-01 7.2e-01
2 Liver alternative TSS ENSRNOT00000002724 0.05 0.03 6.1e-05 0.03 0 0 0.01 5.6e-04 7.6e-02 7.3e-02 8.3e-03
3 Liver alternative TSS ENSRNOT00000089471 0.04 0.03 1.9e-04 0.02 0.01 0.01 0.02 1.7e-03 5.8e-02 1.5e-02 3.1e-03
4 Liver gene expression ENSRNOG00000001990 0.07 0.04 8.1e-06 0.03 0.01 0.02 0 3.6e-04 1.5e-02 5.2e-03 8.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
BMI with tail1.54.89.3-3.01.9-2.11.3
BMI without tail0.51.03.9-2.0-0.1-0.2-0.4
Body weight0.31.13.3-1.80.8-0.60.3
Epididymis fat weight0.20.51.8-1.3-0.0-0.2-0.4
Glucose1.52.33.61.3-1.51.3-1.9
Heart weight0.40.60.9-0.60.8-0.90.7
Left kidney weight0.10.40.80.9-0.70.6-0.2
Right kidney weight0.20.61.0-0.2-0.91.0-0.7
Tail length0.10.20.30.5-0.50.4-0.4
Length with tail0.51.72.71.2-1.21.6-1.2
Length without tail0.20.51.10.5-0.51.1-0.7
Liver weight, left2.33.76.2-0.0-2.31.9-2.5
Liver weight, right2.74.46.80.6-2.32.3-2.6
Parametrial fat weight1.63.24.8-0.1-2.22.1-1.9
Retroperitoneal fat weight0.62.13.5-1.7-1.20.9-1.9
Intraocular pressure0.60.81.4-0.91.2-0.90.6
Extensor digitorum longus weight8.734.947.1-3.26.6-6.96.3
Soleus weight0.51.52.41.60.9-0.91.3
Tibialis anterior weight3.712.815.9-2.84.0-3.93.5
Tibia length0.10.20.3-0.1-0.40.5-0.5
Number of licking bursts0.10.10.2-0.20.3-0.40.3
Food consumed during 24 hour testing period2.32.74.42.1-1.61.7-1.0
Times rat made contact with spout0.20.30.5-0.1-0.40.7-0.7
Mean time between licks in bursts4.46.17.7-2.02.8-2.72.4
Mean num. licks in bursts0.60.81.10.1-0.91.0-1.1
Std. dev. time between licks in bursts1.41.72.7-0.21.7-1.21.6
Water consumed over 24 hours1.72.02.31.1-1.51.5-1.5
Indifference point 0 sec0.30.40.60.2-0.80.7-0.7
Indifference point AUC3.13.75.60.1-2.31.9-2.4
Indifference point function ln k1.21.72.80.11.5-1.31.7
Indifference point function log k1.21.72.80.11.5-1.31.7
Delay discounting total patch changes 0 sec0.30.40.70.1-0.80.7-0.7
Delay discounting total patch changes 12 sec0.70.91.3-0.8-1.20.6-1.1
Delay discounting total patch changes 18 sec0.30.40.7-0.3-0.70.6-0.9
Delay discounting total patch changes 24 sec0.91.11.80.4-1.31.1-1.1
Delay discounting total patch changes 6 sec1.42.23.70.2-1.81.3-1.9
Delay discounting time to switch 0 sec3.35.06.4-1.72.5-2.42.2
Delay discounting water rate 0 sec1.62.53.60.9-1.81.4-1.9
Delay discounting water rate 12 sec0.40.61.71.3-0.50.6-0.4
Delay discounting water rate 18 sec1.82.33.01.7-1.51.4-1.4
Delay discounting water rate 24 sec1.52.05.32.3-1.20.9-0.8
Delay discounting water rate 6 sec0.60.91.30.7-1.00.9-1.1
Locomotor activity0.40.61.91.4-0.30.7-0.2
Locomotor testing distance0.61.03.11.80.20.00.8
Locomotor testing rearing0.50.82.11.40.3-0.40.8
Light reinforcement 10.40.71.20.1-1.11.1-0.8
Light reinforcement 20.10.10.2-0.50.2-0.00.5
Reaction time number correct0.10.20.30.30.5-0.60.0
Reaction time mean minus median0.60.82.1-1.40.6-0.70.6
Reaction time mean minus median AUC0.91.24.1-2.00.4-0.70.1
Reaction time num false alarms0.50.71.8-1.3-0.50.5-0.7
Reaction time num false alarms AUC0.50.72.5-1.6-0.30.2-0.4
Reaction time trials correct on left0.10.20.30.30.5-0.60.0
Reaction time trials on left0.10.20.40.30.5-0.60.1
Reaction time mean0.71.01.8-1.30.8-0.80.9
Reaction time mean AUC0.70.92.3-1.50.7-0.70.8
Median of all reaction times0.60.81.4-1.20.8-0.80.9
Reaction time omissions1.01.42.2-1.01.2-1.50.9
Reaction time false alarm rate0.50.72.3-1.5-0.40.5-0.3
Reaction time premature initiation rate0.20.20.3-0.4-0.60.5-0.3
Reaction time premature initiations0.10.10.2-0.4-0.40.3-0.4
Std. dev. reaction times0.50.71.6-1.30.6-0.70.6
Reaction time trials completed0.10.20.40.30.5-0.60.1
Reaction time trials AUC0.20.20.50.10.6-0.70.1
Social response proportion2.42.65.2-0.0-1.61.6-2.3
Social responses0.91.23.30.2-1.00.8-1.8
Social time0.91.12.00.1-1.11.1-1.4
Conditioned locomotion0.40.50.90.00.6-1.00.9
Cocaine response after cond. corrected0.70.81.00.7-0.91.0-0.9
Cocaine response after cond. not corrected0.70.71.11.0-0.80.9-0.6
Cocaine response before conditioning0.30.30.80.30.6-0.40.9
Saline control response0.40.51.00.5-0.71.0-0.5
Condit. Reinf. active minus inactive responses0.10.10.2-0.2-0.30.4-0.4
Condit. Reinf. active-inactive response ratio0.20.20.4-0.2-0.40.5-0.6
Condit. Reinf. active responses0.10.10.20.2-0.30.4-0.3
Condit. Reinf. inactive responses0.30.30.80.9-0.50.5-0.1
Condit. Reinf. lever presses0.40.61.61.3-0.60.7-0.2
Condit. Reinf. lever reinforcers received0.10.20.40.6-0.40.5-0.2
Pavlov. Cond. lever latency0.40.50.9-0.9-0.60.3-0.9
Pavlov. Cond. magazine entry latency1.11.22.40.41.2-1.01.6
Pavlov. Cond. change in total contacts0.70.91.40.91.0-0.71.2
Pavlov. Cond. index score1.11.42.41.01.2-0.81.6
Pavlov. Cond. latency score1.51.93.31.01.4-1.01.8
Pavlov. Cond. lever contacts0.50.61.61.30.5-0.10.8
Pavlov. Cond. magazine entry number1.92.44.0-0.6-1.81.5-2.0
Pavlov. Cond. intertrial magazine entries1.72.23.3-0.4-1.61.7-1.8
Pavlov. Cond. lever-magazine prob. diff.1.01.32.11.01.1-0.71.4
Pavlov. Cond. response bias0.91.32.01.11.1-0.81.4
Conditioned reinforcement - actives0.30.30.50.40.5-0.50.7
Conditioned reinforcement - inactives1.11.31.41.2-1.21.2-1.0
Conditioned locomotion0.10.10.20.40.3-0.10.4
Intermittent access intake day 1-15 change2.12.13.30.81.5-1.51.8
Intermittent access intake escalation1.31.31.71.11.0-1.01.3
Intermittent access intake escalation 20.30.31.21.1-0.0-0.10.3
Intermitt. access day 1 inactive lever presses1.11.21.61.0-1.31.1-1.0
Intermitt. access day 15 inactive lever presses1.92.13.11.4-1.81.4-1.2
Intermitt. access escalation Index0.70.61.1-0.11.0-0.90.7
Intermittent access day 1 total infusions0.00.10.10.2-0.20.3-0.2
Intermittent access day 15 total infusions0.40.41.61.30.1-0.10.4
Intermittent access terminal intake (last 3 days)0.40.51.61.3-0.40.2-0.1
Intermittent access total infusions0.10.10.30.6-0.10.00.1
Intermittent access day 1 locomotion0.00.00.00.1-0.10.2-0.0
Intermittent access day 15 total locomotion0.10.10.20.30.0-0.20.5
Intermittent access total locomotion0.10.10.2-0.30.3-0.40.3
Intermittent access standard deviation0.30.31.11.0-0.20.20.1
Cocaine induced anxiety0.10.10.2-0.50.4-0.20.2
Post-drug Anxiety0.30.30.8-0.9-0.20.3-0.6
Baseline Anxiety0.40.41.21.1-0.30.2-0.6
Lifetime Intake0.00.00.10.40.0-0.10.1
Incentive Sensitization - Responses0.00.00.1-0.00.2-0.2-0.3
Incentive Sensitization - Breakpoint0.00.00.10.10.1-0.1-0.3
Progressive ratio test 1 active lever presses0.20.20.3-0.50.3-0.10.6
Progressive ratio test 1 breakpoint0.20.20.4-0.40.5-0.20.6
Progressive ratio test 1 inactive lever presses2.02.23.30.9-1.81.8-1.3
Progressive ratio test 2 active lever presses0.10.10.20.0-0.20.2-0.5
Progressive ratio test 2 breakpoint0.00.00.1-0.2-0.00.1-0.3
Progressive ratio test 2 inactive lever presses1.21.41.71.1-1.31.2-1.1
Total sessions with >9 infusions1.11.22.30.31.2-1.51.1
Short access day 1 total inactive lever presses1.71.94.22.1-1.31.1-0.7
Short access day 10 total inactive lever presses1.51.73.21.8-1.31.2-0.7
Short access day 1 total infusions0.10.10.4-0.1-0.20.6-0.0
Short access day 10 total infusions0.10.10.20.20.1-0.20.4
Short access total infusions0.10.10.2-0.20.4-0.40.4
Short access day 1 locomotion0.10.10.3-0.30.5-0.40.2
Short access day 10 total locomotion0.20.30.7-0.80.4-0.4-0.1
Short access total locomotion0.40.40.6-0.60.7-0.70.5
Compulsive drug intake0.50.50.9-0.4-0.50.8-0.9
One hour access (0.3 mA shock)0.30.30.70.8-0.40.4-0.5
One hour access (shock baseline)0.00.00.10.40.0-0.20.1
Number of responses in last shaping day0.50.50.7-0.70.9-0.50.6
Context. condit. distance diff. score1.11.45.02.2-0.10.30.6
Locomotion velocity, session 10.91.02.9-1.70.7-0.60.1
Locomotion distance, session 10.20.30.40.4-0.50.6-0.5
Locomotion velocity, session 20.10.10.20.4-0.10.30.1
Locomotion distance, session 20.10.10.20.1-0.40.5-0.3
Locomotion velocity, session 30.60.70.90.6-1.00.9-0.9
Locomotion distance, session 30.00.00.10.2-0.20.20.1
Stereotopy head waving bouts, day 30.60.71.1-1.10.8-0.90.3
Stereotopy head waving duration, day 30.10.10.2-0.40.2-0.3-0.1
Locomotion velocity, session 71.92.13.00.2-1.71.6-1.7
Locomotion distance, session 71.11.41.80.9-1.31.4-1.0
Stereotopy head waving bouts, day 70.20.20.40.10.6-0.70.1
Stereotopy head waving duration, day 70.40.51.2-1.10.5-0.5-0.4
Locomotion velocity, session 80.20.20.70.90.10.00.3
Locomotion distance, session 81.11.65.12.3-0.60.90.1
Degree of sensitization distance0.90.91.00.9-1.01.0-0.9
Degree of sensitization stereotypy0.10.10.10.30.1-0.2-0.3
Condit. Reinf. active minus inactive responses0.80.81.3-1.10.8-0.70.9
Condit. Reinf. active-inactive response ratio2.93.24.3-1.02.0-1.82.1
Condit. Reinf. active responses0.10.10.2-0.4-0.30.4-0.1
Condit. Reinf. inactive responses2.32.73.70.8-1.91.8-1.7
Incentive salience index mean0.10.10.4-0.60.3-0.10.3
Condit. Reinf. lever presses0.00.00.00.1-0.00.20.1
Time in familiar zone, hab. session 10.40.41.11.0-0.30.6-0.2
Time in novel zone, hab. session 11.31.23.8-2.00.6-0.80.2
Total zone transitions, hab. session 10.20.30.50.2-0.60.7-0.2
Total locomotion distance, hab. session 11.72.43.11.7-1.81.7-0.9
Locomotion velocity, hab. session 11.62.23.71.9-1.61.5-0.7
Time in familiar zone, hab. session 20.00.00.1-0.00.10.10.3
Time in novel zone, hab. session 20.50.51.6-1.30.2-0.4-0.3
Total zone transitions, hab. session 20.10.20.50.7-0.10.20.3
Total locomotion distance, hab. session 20.60.81.61.3-0.80.9-0.3
Locomotion velocity, hab. session 20.70.92.01.4-0.80.9-0.3
Novel to familiar place preference ratio0.50.51.5-1.2-0.20.3-0.5
Novelty place preference0.70.72.6-1.60.10.1-0.4
Time in novel zone, NPP test0.80.82.8-1.7-0.20.3-0.7
Total zone transitions, NPP test0.00.10.1-0.1-0.40.3-0.2
Total locomotion distance, NPP test0.30.41.11.1-0.50.50.2
Locomotion velocity, NPP test0.20.31.01.0-0.20.20.6
Pavlov. Cond. lever latency0.50.61.00.40.8-1.00.8
Pavlov. Cond. magazine entry latency0.10.20.60.8-0.10.2-0.1
Pavlov. Cond. change in total contacts0.10.10.3-0.50.00.20.0
Pavlov. Cond. index score0.20.20.3-0.3-0.40.5-0.5
Pavlov. Cond. latency score0.20.30.5-0.2-0.50.7-0.6
Pavlov. Cond. lever contacts0.50.61.1-0.2-0.81.1-0.8
Pavlov. Cond. magazine entry number0.00.10.10.2-0.30.3-0.1
Pavlov. Cond. intertrial magazine entries0.60.71.1-1.1-0.80.6-0.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.1-0.50.7-0.6
Pavlov. Cond. response bias0.20.30.4-0.0-0.50.6-0.6
Bone: apparent density0.20.40.6-0.30.6-0.70.8
Bone surface0.30.50.90.80.5-0.40.9
Bone volume0.00.10.20.5-0.20.20.2
Bone: connectivity density0.60.91.2-0.80.9-0.91.1
Bone: cortical apparent density1.11.53.8-2.0-0.60.2-1.3
Bone: cortical area0.10.20.3-0.2-0.40.5-0.6
Bone: cortical porosity2.02.23.8-0.01.6-1.52.0
Bone: cortical porosity3.03.24.7-0.62.1-1.92.2
Bone: cortical thickness0.50.80.9-1.01.0-0.80.8
Bone: cortical thickness0.20.30.91.0-0.10.10.3
Bone: cortical tissue density1.11.43.9-2.0-0.50.1-1.2
Bone: elastic displacement0.70.81.21.00.8-0.81.1
Bone: elastic work0.60.81.21.10.7-0.51.1
Bone: endosteal estimation1.43.13.51.8-1.71.9-1.6
Bone: endosteal perimeter0.40.81.51.2-0.70.9-0.7
Bone: final force0.00.10.2-0.1-0.00.1-0.4
Bone: final moment0.00.10.2-0.1-0.00.1-0.5
Bone: marrow area1.42.93.61.9-1.61.8-1.5
Bone: maximum diameter0.10.20.5-0.70.2-0.1-0.2
Bone: maximum force0.10.20.30.5-0.30.5-0.6
Bone: maximum moment0.20.30.50.5-0.40.6-0.7
Bone: minimum diameter4.07.311.01.5-2.83.3-2.9
Bone: periosteal estimation0.51.11.40.9-1.01.2-1.1
Bone: periosteal perimeter0.30.60.80.9-0.70.7-0.7
Bone: post-yield work0.10.20.2-0.4-0.30.5-0.4
Bone: stiffness0.91.42.6-0.7-1.01.2-1.6
Bone: tissue strength0.70.71.10.2-0.90.9-1.0
Bone: trabecular number0.20.30.8-0.90.3-0.40.3
Bone: trabecular spacing0.40.62.0-1.4-0.1-0.1-0.5
Bone: trabecular thickness0.20.20.70.9-0.40.30.0
Bone: trabecular tissue density0.50.61.6-1.30.8-0.50.3
Breakpoint value in progressive ratio session0.20.20.5-0.2-0.30.6-0.7
Distance traveled before self-admin0.30.40.60.1-0.60.8-0.7
Distance traveled after self-admin2.93.24.52.1-1.81.8-1.4
Delta time in closed arm before/after self-admin0.90.91.2-1.01.0-1.10.7
Delta time in open arm before/after self-admin1.00.91.50.1-1.21.2-0.9
Diff in mean of infusions in LGA sessions0.00.00.10.30.0-0.20.1
Extinction: sum of active levers before priming0.80.81.00.8-0.91.0-0.8
Active lever presses in extinction session 60.70.71.10.5-0.91.0-0.8
Delta distance traveled before/after self-admin0.60.61.41.2-0.70.6-0.4
Delta ambulatory time before/after self-admin0.20.20.70.9-0.30.20.0
Time in closed arm before self-admin0.50.60.80.7-0.80.9-0.6
Time in closed arm after self-admin0.30.30.30.50.4-0.60.5
Time in open arm before self-admin1.31.42.10.51.3-1.31.5
Time in open arm after self-admin1.01.11.5-0.3-1.21.2-1.2
Sum of active levers in priming session hrs 5-61.01.01.21.0-0.91.1-1.0
Time to tail flick, vehicle, before self-admin0.30.30.50.5-0.70.7-0.3
Time to tail flick, vehicle, after self-admin1.21.34.42.1-0.70.6-0.2
Time to tail flick, test, before self-admin0.00.00.10.2-0.00.00.3
Time to tail flick, test, after self-admin1.51.52.30.6-1.51.5-1.1
Delta time to tail flick, vehicle, before/after SA0.20.20.30.6-0.30.2-0.4
Delta time to tail flick, test, before/after SA1.31.11.8-0.2-1.21.1-1.3
Ambulatory time before self-admin0.50.50.80.1-0.80.7-0.9
Ambulatory time after self-admin2.83.13.41.8-1.81.8-1.6
Total heroin consumption1.62.02.11.5-1.41.4-1.3
Area under the delay curve0.10.10.4-0.60.0-0.2-0.2
Delay disc. indifference point, 0s delay0.20.20.8-0.90.3-0.3-0.1
Delay disc. indifference point, 16s delay1.01.02.6-1.60.7-0.90.1
Delay disc. indifference point, 2s delay2.42.73.60.8-1.91.8-1.9
Delay disc. indifference point, 24s delay0.20.20.3-0.10.4-0.50.5
Delay disc. indifference point, 4s delay0.70.81.7-0.7-0.70.6-1.3
Delay disc. indifference point, 8s delay1.51.62.0-1.41.2-1.31.1
Delay discount exponential model param0.10.10.20.50.20.00.4
Delay discount hyperbolic model param0.20.30.60.30.5-0.30.7
Fecal boli incidents, locomotor time 11.11.21.90.01.2-1.41.2
Change in fecal boli incidents, locomotor task0.00.00.00.20.1-0.10.0
Time >=10cm from walls, locomotor time 10.90.91.9-0.11.1-1.40.8
Bouts of movement, locomotor time 10.91.01.1-1.01.0-1.00.9
Total resting periods, locomotor time 10.60.70.8-0.90.8-0.80.7
Rest time, locomotor task time 10.91.02.71.6-0.70.80.1
Distance moved, locomotor task time 10.10.10.2-0.50.3-0.4-0.1
Vertical activity count, locomotor time 11.21.22.6-1.6-0.50.4-1.4
Time >=10cm from walls, locomotor time 20.30.40.70.80.3-0.40.7
Bouts of movement, locomotor time 20.10.10.30.2-0.50.4-0.0
Total resting periods, locomotor time 20.10.10.20.0-0.40.3-0.0
Rest time, locomotor task time 20.91.03.41.8-0.60.70.2
Distance moved, locomotor task time 21.31.52.1-1.41.2-1.21.0
Vertical activity count, locomotor time 20.70.82.8-1.7-0.1-0.1-0.6
Weight adjusted by age1.31.42.60.01.2-1.41.6
Seeking ratio, delayed vs. immediate footshock1.01.11.91.0-1.11.4-0.6
Locomotion in novel chamber0.10.10.4-0.2-0.20.2-0.7
Locomotion in novel chamber post-restriction0.91.11.7-0.3-1.21.0-1.3
Progressive ratio0.60.71.00.30.8-0.91.0
Food seeking constrained by brief footshock0.10.20.3-0.30.3-0.30.6
Seeking ratio, punishment vs. effort0.50.60.9-0.6-0.90.9-0.8
Run reversals in cocaine runway, females2.12.13.21.2-1.81.6-1.1
Run reversals in cocaine runway, males0.10.10.20.20.4-0.50.0
Latency to leave start box in cocaine runway2.93.14.20.8-2.01.9-2.0
Latency to leave start box in cocaine runway, F4.55.07.00.9-2.42.5-2.7
Latency to leave start box in cocaine runway, M0.20.20.30.10.3-0.40.6
Cd content in liver1.21.31.8-0.91.3-1.31.0
Co content in liver0.10.10.2-0.2-0.20.5-0.1
Cu content in liver0.40.51.0-0.2-0.61.0-0.6
Fe content in liver1.01.23.7-1.90.8-0.50.5
K content in liver1.71.72.5-1.2-1.11.6-1.2
Mg content in liver1.81.82.2-1.5-1.11.4-1.3
Mn content in liver0.10.10.2-0.20.4-0.20.5
Na content in liver1.71.83.1-0.9-1.31.3-1.8
Rb content in liver0.81.01.7-1.30.9-1.10.4
Se content in liver0.10.10.2-0.4-0.30.2-0.2
Sr content in liver0.70.61.01.00.4-0.71.0
Zn content in liver1.01.11.70.6-1.31.2-1.1