Hub : Genes

Sult1e1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000001957 0.02 0.02 4e-03 0.02 0.01 0.01 0.01 2.2e-03 9.3e-03 9.2e-03 1.2e-02
2 Liver gene expression ENSRNOG00000001957 0.61 0.12 0e+00 0.42 0.38 0.44 0.44 1.2e-50 3.5e-44 6.3e-53 7.4e-53
3 Liver mRNA stability ENSRNOG00000001957 0.18 0.08 0e+00 0.12 0.12 0.1 0.12 1.8e-13 4.0e-13 1.1e-11 4.9e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
BMI with tail1.44.76.4-1.9-2.52.0
BMI without tail0.00.10.10.3-0.2-0.3
Body weight0.10.30.4-0.1-0.70.6
Epididymis fat weight0.00.10.10.3-0.30.1
Glucose1.01.61.71.31.3-1.2
Heart weight0.30.50.80.4-0.60.9
Left kidney weight0.71.93.01.71.5-0.8
Right kidney weight0.92.64.72.21.5-1.0
Tail length0.20.61.00.61.0-0.7
Length with tail0.93.34.31.92.1-1.4
Length without tail0.30.71.01.01.0-0.5
Liver weight, left1.72.84.51.31.4-2.1
Liver weight, right2.23.65.41.51.8-2.3
Parametrial fat weight1.22.43.41.31.5-1.8
Retroperitoneal fat weight0.30.91.71.30.7-0.8
Intraocular pressure0.70.91.5-0.5-1.01.2
Extensor digitorum longus weight11.044.248.8-6.3-7.06.6
Soleus weight0.30.91.2-0.9-0.81.1
Tibialis anterior weight3.913.516.1-3.0-4.04.0
Tibia length0.20.70.90.90.9-0.6
Number of licking bursts0.10.10.2-0.3-0.40.3
Food consumed during 24 hour testing period2.32.83.61.51.7-1.9
Times rat made contact with spout0.20.30.60.40.3-0.8
Mean time between licks in bursts4.15.76.6-2.0-2.52.6
Mean num. licks in bursts0.80.91.20.90.9-1.1
Std. dev. time between licks in bursts1.11.41.8-1.0-1.11.3
Water consumed over 24 hours2.12.52.71.61.4-1.6
Indifference point 0 sec0.10.20.4-0.00.5-0.6
Indifference point AUC2.93.43.71.91.8-1.9
Indifference point function ln k1.01.51.8-1.3-1.01.3
Indifference point function log k1.01.51.8-1.3-1.01.3
Delay discounting total patch changes 0 sec0.10.20.40.00.5-0.6
Delay discounting total patch changes 12 sec0.40.50.80.90.6-0.6
Delay discounting total patch changes 18 sec0.10.10.2-0.20.2-0.4
Delay discounting total patch changes 24 sec0.70.91.20.71.0-1.1
Delay discounting total patch changes 6 sec1.11.61.91.11.4-1.3
Delay discounting time to switch 0 sec3.85.86.4-2.4-2.52.4
Delay discounting water rate 0 sec2.13.44.42.11.9-1.5
Delay discounting water rate 12 sec0.71.11.81.41.1-0.6
Delay discounting water rate 18 sec2.23.03.61.71.9-1.5
Delay discounting water rate 24 sec1.62.22.91.71.6-1.0
Delay discounting water rate 6 sec1.11.63.01.71.1-0.7
Locomotor activity0.50.81.21.01.1-0.4
Locomotor testing distance0.20.30.60.40.8-0.1
Locomotor testing rearing0.10.10.20.30.40.2
Light reinforcement 10.61.11.21.11.1-1.0
Light reinforcement 20.20.30.8-0.9-0.1-0.0
Reaction time number correct0.20.30.50.7-0.00.5
Reaction time mean minus median0.70.91.4-0.9-1.20.7
Reaction time mean minus median AUC0.50.61.1-0.7-1.00.5
Reaction time num false alarms0.40.61.51.20.2-0.5
Reaction time num false alarms AUC0.10.20.40.7-0.3-0.2
Reaction time trials correct on left0.20.30.50.7-0.00.5
Reaction time trials on left0.20.30.50.7-0.10.5
Reaction time mean0.70.91.0-1.0-1.00.8
Reaction time mean AUC0.50.60.7-0.8-0.80.7
Median of all reaction times0.60.81.0-1.0-0.90.8
Reaction time omissions1.11.52.2-0.8-1.51.3
Reaction time false alarm rate0.10.10.10.2-0.2-0.4
Reaction time premature initiation rate0.20.30.6-0.00.6-0.8
Reaction time premature initiations0.30.40.50.50.7-0.6
Std. dev. reaction times0.40.50.8-0.6-0.90.7
Reaction time trials completed0.20.30.50.7-0.10.5
Reaction time trials AUC0.20.30.50.7-0.20.6
Social response proportion1.61.83.10.61.3-1.8
Social responses0.91.11.31.11.0-1.1
Social time0.60.81.20.51.0-1.1
Conditioned locomotion0.30.40.6-0.4-0.60.8
Cocaine response after cond. corrected0.80.91.00.90.9-1.0
Cocaine response after cond. not corrected0.80.90.90.90.9-0.9
Cocaine response before conditioning0.10.20.2-0.4-0.20.5
Saline control response0.81.11.11.01.1-1.0
Condit. Reinf. active minus inactive responses0.10.20.3-0.40.1-0.6
Condit. Reinf. active-inactive response ratio0.20.20.40.10.2-0.7
Condit. Reinf. active responses0.10.20.4-0.20.3-0.6
Condit. Reinf. inactive responses0.30.40.60.50.8-0.6
Condit. Reinf. lever presses0.40.60.60.70.8-0.8
Condit. Reinf. lever reinforcers received0.10.20.3-0.10.4-0.6
Pavlov. Cond. lever latency0.20.20.50.70.2-0.4
Pavlov. Cond. magazine entry latency1.01.21.3-1.1-1.01.1
Pavlov. Cond. change in total contacts0.40.60.9-0.9-0.50.7
Pavlov. Cond. index score0.71.01.3-1.2-0.71.0
Pavlov. Cond. latency score1.01.31.5-1.2-0.91.2
Pavlov. Cond. lever contacts0.10.20.5-0.7-0.00.2
Pavlov. Cond. magazine entry number1.61.92.11.41.3-1.5
Pavlov. Cond. intertrial magazine entries1.62.12.81.31.3-1.7
Pavlov. Cond. lever-magazine prob. diff.0.70.91.3-1.1-0.70.9
Pavlov. Cond. response bias0.70.91.6-1.3-0.70.8
Conditioned reinforcement - actives0.10.10.30.30.10.5
Conditioned reinforcement - inactives1.11.31.70.71.3-1.2
Conditioned locomotion0.10.20.40.60.30.2
Intermittent access intake day 1-15 change0.80.81.4-0.3-0.91.2
Intermittent access intake escalation0.40.40.80.0-0.50.9
Intermittent access intake escalation 20.40.40.70.80.6-0.0
Intermitt. access day 1 inactive lever presses0.50.61.00.21.0-0.9
Intermitt. access day 15 inactive lever presses1.21.31.81.01.3-1.1
Intermitt. access escalation Index1.61.41.9-1.4-1.30.9
Intermittent access day 1 total infusions0.10.10.2-0.40.2-0.1
Intermittent access day 15 total infusions0.10.10.10.20.30.1
Intermittent access terminal intake (last 3 days)0.50.50.90.80.9-0.2
Intermittent access total infusions0.00.00.10.10.4-0.1
Intermittent access day 1 locomotion0.00.00.10.00.3-0.1
Intermittent access day 15 total locomotion0.20.20.40.50.60.2
Intermittent access total locomotion0.10.10.20.10.00.4
Intermittent access standard deviation0.50.51.21.10.5-0.2
Cocaine induced anxiety0.10.10.2-0.3-0.40.1
Post-drug Anxiety0.00.00.10.10.1-0.3
Baseline Anxiety0.10.10.2-0.10.5-0.2
Lifetime Intake0.00.00.0-0.20.0-0.0
Incentive Sensitization - Responses0.10.10.20.00.00.4
Incentive Sensitization - Breakpoint0.10.10.20.10.20.4
Progressive ratio test 1 active lever presses0.00.00.0-0.10.10.1
Progressive ratio test 1 breakpoint0.00.00.1-0.1-0.00.3
Progressive ratio test 1 inactive lever presses2.12.23.01.21.5-1.7
Progressive ratio test 2 active lever presses0.10.10.30.30.50.0
Progressive ratio test 2 breakpoint0.10.10.10.30.40.1
Progressive ratio test 2 inactive lever presses0.80.91.70.31.3-1.0
Total sessions with >9 infusions1.71.92.1-1.4-1.41.3
Short access day 1 total inactive lever presses0.91.01.70.41.3-1.1
Short access day 10 total inactive lever presses1.01.11.20.91.1-1.1
Short access day 1 total infusions0.10.10.20.20.1-0.5
Short access day 10 total infusions0.30.30.8-0.9-0.30.1
Short access total infusions0.40.40.7-0.8-0.60.3
Short access day 1 locomotion0.10.10.10.0-0.30.4
Short access day 10 total locomotion0.20.20.4-0.1-0.30.6
Short access total locomotion0.40.40.6-0.5-0.70.8
Compulsive drug intake0.20.20.5-0.3-0.2-0.7
One hour access (0.3 mA shock)0.20.30.60.20.8-0.5
One hour access (shock baseline)0.10.10.30.30.50.1
Number of responses in last shaping day0.80.81.2-1.1-1.00.4
Context. condit. distance diff. score0.30.40.70.60.9-0.2
Locomotion velocity, session 10.90.91.1-1.1-1.10.7
Locomotion distance, session 10.20.30.40.30.6-0.6
Locomotion velocity, session 20.10.10.10.30.3-0.2
Locomotion distance, session 20.10.20.20.30.4-0.4
Locomotion velocity, session 30.50.60.90.10.9-1.0
Locomotion distance, session 30.10.10.3-0.50.1-0.2
Stereotopy head waving bouts, day 30.50.70.8-0.9-0.80.7
Stereotopy head waving duration, day 30.10.10.2-0.5-0.20.2
Locomotion velocity, session 72.52.83.21.61.6-1.8
Locomotion distance, session 71.62.12.51.61.4-1.4
Stereotopy head waving bouts, day 70.30.30.4-0.6-0.40.6
Stereotopy head waving duration, day 70.30.40.5-0.7-0.70.5
Locomotion velocity, session 80.00.00.0-0.10.10.1
Locomotion distance, session 80.91.31.91.11.4-0.7
Degree of sensitization distance2.32.34.22.01.3-1.1
Degree of sensitization stereotypy0.00.00.0-0.1-0.10.1
Condit. Reinf. active minus inactive responses0.60.60.9-0.4-1.00.9
Condit. Reinf. active-inactive response ratio3.03.24.2-1.4-1.92.0
Condit. Reinf. active responses0.10.10.10.40.0-0.3
Condit. Reinf. inactive responses2.63.03.61.61.7-1.9
Incentive salience index mean0.10.10.10.1-0.40.2
Condit. Reinf. lever presses0.00.00.10.3-0.0-0.2
Time in familiar zone, hab. session 10.10.10.10.00.4-0.3
Time in novel zone, hab. session 10.40.40.7-0.5-0.80.5
Total zone transitions, hab. session 10.20.30.50.50.4-0.7
Total locomotion distance, hab. session 11.72.43.11.21.8-1.7
Locomotion velocity, hab. session 11.42.02.81.01.7-1.5
Time in familiar zone, hab. session 20.30.30.6-0.8-0.50.2
Time in novel zone, hab. session 20.20.20.70.80.10.1
Total zone transitions, hab. session 20.00.00.10.00.3-0.2
Total locomotion distance, hab. session 20.60.71.20.61.1-0.8
Locomotion velocity, hab. session 20.50.71.20.51.1-0.8
Novel to familiar place preference ratio0.10.10.30.4-0.0-0.5
Novelty place preference0.10.10.10.2-0.3-0.3
Time in novel zone, NPP test0.10.20.20.4-0.1-0.5
Total zone transitions, NPP test0.00.00.1-0.10.1-0.3
Total locomotion distance, NPP test0.10.20.30.10.6-0.5
Locomotion velocity, NPP test0.00.10.1-0.30.2-0.1
Pavlov. Cond. lever latency1.52.03.6-1.9-1.11.0
Pavlov. Cond. magazine entry latency0.00.10.10.10.2-0.3
Pavlov. Cond. change in total contacts0.30.30.80.90.3-0.2
Pavlov. Cond. index score0.40.61.01.00.6-0.6
Pavlov. Cond. latency score0.70.91.51.20.7-0.7
Pavlov. Cond. lever contacts1.72.13.71.91.2-1.0
Pavlov. Cond. magazine entry number0.00.00.0-0.10.1-0.2
Pavlov. Cond. intertrial magazine entries0.50.61.11.10.7-0.6
Pavlov. Cond. lever-magazine prob. diff.0.50.60.91.00.6-0.7
Pavlov. Cond. response bias0.50.60.91.00.7-0.7
Bone: apparent density0.20.40.5-0.6-0.70.6
Bone surface0.00.00.10.0-0.00.4
Bone volume0.10.10.20.40.4-0.3
Bone: connectivity density0.71.11.3-1.0-1.20.9
Bone: cortical apparent density0.10.20.2-0.4-0.5-0.4
Bone: cortical area0.60.91.61.30.8-0.6
Bone: cortical porosity2.02.22.4-1.4-1.51.5
Bone: cortical porosity3.03.23.8-1.6-1.81.9
Bone: cortical thickness0.20.30.5-0.3-0.70.7
Bone: cortical thickness0.10.20.30.30.5-0.3
Bone: cortical tissue density0.20.30.3-0.6-0.6-0.3
Bone: elastic displacement0.50.50.6-0.8-0.70.7
Bone: elastic work0.30.40.7-0.9-0.60.4
Bone: endosteal estimation2.14.55.62.12.4-1.9
Bone: endosteal perimeter0.51.01.31.11.1-0.8
Bone: final force0.20.40.70.80.5-0.3
Bone: final moment0.30.40.91.00.6-0.3
Bone: marrow area2.04.25.32.02.3-1.8
Bone: maximum diameter0.10.20.60.80.2-0.1
Bone: maximum force0.61.01.71.31.0-0.7
Bone: maximum moment0.71.32.21.51.1-0.7
Bone: minimum diameter7.213.415.03.93.8-3.3
Bone: periosteal estimation1.32.63.21.81.7-1.3
Bone: periosteal perimeter0.61.11.31.11.1-0.9
Bone: post-yield work0.30.40.50.70.6-0.4
Bone: stiffness1.62.53.82.01.4-1.3
Bone: tissue strength1.21.11.31.11.0-1.0
Bone: trabecular number0.20.40.5-0.7-0.70.3
Bone: trabecular spacing0.10.10.20.5-0.00.1
Bone: trabecular thickness0.10.10.1-0.00.3-0.3
Bone: trabecular tissue density0.30.40.5-0.5-0.70.7
Breakpoint value in progressive ratio session0.20.20.30.30.5-0.6
Distance traveled before self-admin0.60.60.80.90.8-0.6
Distance traveled after self-admin3.33.64.71.92.2-1.6
Delta time in closed arm before/after self-admin1.21.21.6-0.7-1.21.3
Delta time in open arm before/after self-admin1.00.91.60.21.1-1.3
Diff in mean of infusions in LGA sessions0.00.00.0-0.1-0.00.1
Extinction: sum of active levers before priming0.30.30.60.00.6-0.7
Active lever presses in extinction session 60.70.70.90.80.8-1.0
Delta distance traveled before/after self-admin0.40.40.40.60.7-0.6
Delta ambulatory time before/after self-admin0.10.10.10.30.4-0.3
Time in closed arm before self-admin0.70.81.00.71.0-0.9
Time in closed arm after self-admin0.10.10.40.0-0.10.6
Time in open arm before self-admin0.80.91.7-0.1-0.91.3
Time in open arm after self-admin0.80.91.70.50.8-1.3
Sum of active levers in priming session hrs 5-60.70.71.40.30.8-1.2
Time to tail flick, vehicle, before self-admin0.80.81.00.70.9-1.0
Time to tail flick, vehicle, after self-admin0.91.01.41.21.2-0.6
Time to tail flick, test, before self-admin0.10.10.20.40.0-0.4
Time to tail flick, test, after self-admin2.72.83.71.91.5-1.6
Delta time to tail flick, vehicle, before/after SA0.30.30.70.80.5-0.1
Delta time to tail flick, test, before/after SA1.21.01.11.01.1-0.9
Ambulatory time before self-admin0.80.91.31.01.1-0.6
Ambulatory time after self-admin2.93.24.21.62.1-1.6
Total heroin consumption1.92.32.81.71.5-1.3
Area under the delay curve0.00.00.10.2-0.00.1
Delay disc. indifference point, 0s delay0.10.10.20.1-0.40.2
Delay disc. indifference point, 16s delay0.40.40.5-0.5-0.70.7
Delay disc. indifference point, 2s delay3.13.54.62.11.8-1.7
Delay disc. indifference point, 24s delay0.20.10.4-0.3-0.10.6
Delay disc. indifference point, 4s delay0.40.40.80.90.4-0.6
Delay disc. indifference point, 8s delay1.21.31.6-0.8-1.21.3
Delay discount exponential model param0.00.00.1-0.4-0.1-0.0
Delay discount hyperbolic model param0.20.30.5-0.7-0.40.3
Fecal boli incidents, locomotor time 11.31.42.0-1.1-1.11.4
Change in fecal boli incidents, locomotor task0.50.51.3-1.1-0.50.2
Time >=10cm from walls, locomotor time 12.22.23.9-2.0-1.31.1
Bouts of movement, locomotor time 10.91.01.2-1.0-1.10.9
Total resting periods, locomotor time 10.80.91.2-1.1-1.00.8
Rest time, locomotor task time 10.40.50.7-0.30.8-0.8
Distance moved, locomotor task time 10.10.10.20.3-0.40.4
Vertical activity count, locomotor time 10.80.82.01.40.3-0.5
Time >=10cm from walls, locomotor time 20.80.92.3-1.5-0.50.3
Bouts of movement, locomotor time 20.10.20.2-0.30.5-0.4
Total resting periods, locomotor time 20.10.10.2-0.40.4-0.3
Rest time, locomotor task time 20.50.60.7-0.90.8-0.6
Distance moved, locomotor task time 21.21.32.5-0.2-1.61.2
Vertical activity count, locomotor time 20.40.51.21.1-0.4-0.1
Weight adjusted by age1.51.72.5-1.6-1.01.2
Seeking ratio, delayed vs. immediate footshock0.91.01.70.61.0-1.3
Locomotion in novel chamber0.00.00.0-0.00.1-0.1
Locomotion in novel chamber post-restriction0.70.91.40.51.0-1.2
Progressive ratio0.60.70.7-0.8-0.80.8
Food seeking constrained by brief footshock0.10.20.3-0.3-0.60.3
Seeking ratio, punishment vs. effort0.40.50.60.80.6-0.7
Run reversals in cocaine runway, females4.24.26.52.61.9-1.5
Run reversals in cocaine runway, males0.30.30.3-0.6-0.40.5
Latency to leave start box in cocaine runway2.22.44.70.11.6-2.2
Latency to leave start box in cocaine runway, F3.74.06.30.92.2-2.5
Latency to leave start box in cocaine runway, M0.70.61.7-1.3-0.50.1
Cd content in liver2.02.22.3-1.5-1.51.4
Co content in liver0.00.00.1-0.10.2-0.2
Cu content in liver0.60.81.01.00.8-0.9
Fe content in liver0.60.70.9-0.6-0.90.9
K content in liver1.21.21.71.01.0-1.3
Mg content in liver1.21.21.80.91.0-1.3
Mn content in liver0.00.10.20.1-0.00.4
Na content in liver0.80.81.20.80.8-1.1
Rb content in liver0.70.81.1-0.7-1.01.1
Se content in liver0.10.10.10.30.3-0.2
Sr content in liver0.30.30.6-0.4-0.20.8
Zn content in liver0.70.81.50.50.8-1.2