Hub : Genes

Far2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	ENSRNOG00000001851	0.06	0.04	1.7e-03	0.04	0.03	0.03	0.04	1.8e-03	6.1e-03	9.4e-03	3.2e-03
2	Brain	mRNA stability	ENSRNOG00000001851	0.1	0.06	8.9e-12	0.13	0.12	0.11	0.12	7.3e-12	2.0e-11	1.1e-10	8.1e-11
3	NAcc	gene expression	ENSRNOG00000001851	0.04	0.03	8.8e-04	0.03	0.04	0.03	0.04	1.3e-03	1.1e-03	1.3e-03	1.2e-03
4	PL	gene expression	ENSRNOG00000001851	0.04	0.03	8.7e-04	0.04	0.02	0.01	0.03	6.4e-04	5.8e-03	1.1e-01	4.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
BMI with tail	2.4	7.7	8.7	-2.4	2.9	-2.7	-2.9
BMI without tail	2.8	5.9	7.3	-1.7	2.7	-2.4	-2.7
Body weight	0.3	1.2	1.7	-0.8	1.3	-0.8	-1.3
Epididymis fat weight	0.0	0.0	0.0	0.2	-0.2	-0.1	0.2
Glucose	3.6	5.4	6.3	-2.2	2.3	-2.5	-2.3
Heart weight	0.9	1.3	2.2	-0.4	1.5	-0.9	-1.4
Left kidney weight	0.2	0.7	1.1	0.1	1.0	-0.8	-1.0
Right kidney weight	0.1	0.3	0.4	0.2	0.6	-0.5	-0.6
Tail length	0.2	0.6	1.6	1.3	-0.5	0.6	0.5
Length with tail	0.3	1.0	1.3	1.1	-0.9	1.2	0.8
Length without tail	0.3	0.6	0.9	0.7	-0.8	1.0	0.7
Liver weight, left	0.1	0.1	0.3	-0.6	-0.1	-0.4	0.1
Liver weight, right	0.2	0.4	1.1	-1.1	0.3	-0.4	-0.4
Parametrial fat weight	1.1	2.1	3.0	-1.3	1.4	-1.7	-1.3
Retroperitoneal fat weight	0.8	2.5	3.2	-1.4	1.5	-1.8	-1.6
Intraocular pressure	0.5	0.8	1.0	0.7	-0.9	1.0	0.9
Extensor digitorum longus weight	0.7	2.9	3.4	-1.4	1.8	-1.9	-1.8
Soleus weight	1.7	5.1	5.4	-2.3	2.2	-2.2	-2.3
Tibialis anterior weight	2.2	7.4	8.0	-2.7	2.7	-2.8	-2.7
Tibia length	3.2	8.9	9.6	3.1	-3.0	2.9	2.9
Number of licking bursts	0.9	1.1	1.4	0.5	-1.2	1.1	1.2
Food consumed during 24 hour testing period	3.0	3.7	4.5	-1.8	2.1	-1.6	-2.1
Times rat made contact with spout	0.1	0.1	0.1	0.1	0.4	-0.2	-0.4
Mean time between licks in bursts	0.5	0.7	0.9	0.5	-0.9	0.9	0.9
Mean num. licks in bursts	0.9	1.1	1.5	-0.3	1.2	-1.1	-1.2
Std. dev. time between licks in bursts	1.9	2.2	2.9	1.4	-1.4	1.7	1.4
Water consumed over 24 hours	0.2	0.3	0.5	-0.2	0.7	-0.3	-0.7
Indifference point 0 sec	0.1	0.2	0.4	0.5	-0.2	0.6	0.2
Indifference point AUC	1.2	1.4	1.8	0.6	-1.3	1.3	1.3
Indifference point function ln k	0.1	0.2	0.5	0.7	-0.2	0.3	0.1
Indifference point function log k	0.1	0.2	0.5	0.7	-0.2	0.3	0.1
Delay discounting total patch changes 0 sec	0.1	0.2	0.4	0.4	-0.3	0.6	0.2
Delay discounting total patch changes 12 sec	0.3	0.3	0.8	0.1	-0.6	0.9	0.5
Delay discounting total patch changes 18 sec	0.2	0.3	0.6	0.1	-0.5	0.8	0.5
Delay discounting total patch changes 24 sec	1.0	1.2	1.5	1.1	-1.1	1.2	1.0
Delay discounting total patch changes 6 sec	0.6	0.9	1.5	0.8	-0.8	1.2	0.8
Delay discounting time to switch 0 sec	1.3	2.1	2.4	-1.4	1.3	-1.6	-1.4
Delay discounting water rate 0 sec	0.6	0.9	1.4	0.9	-0.7	1.2	0.8
Delay discounting water rate 12 sec	0.1	0.1	0.5	0.7	0.1	0.2	-0.0
Delay discounting water rate 18 sec	0.0	0.0	0.2	0.4	-0.0	-0.0	0.1
Delay discounting water rate 24 sec	0.6	0.8	1.3	1.1	-0.8	0.7	0.8
Delay discounting water rate 6 sec	0.0	0.0	0.1	-0.2	0.2	0.0	-0.2
Locomotor activity	0.5	0.8	2.2	-1.5	0.6	-0.3	-0.6
Locomotor testing distance	0.5	0.8	1.6	-1.3	0.8	-0.4	-0.8
Locomotor testing rearing	0.1	0.1	0.4	-0.6	0.1	0.1	-0.2
Light reinforcement 1	0.2	0.3	0.6	0.1	-0.7	0.8	0.5
Light reinforcement 2	0.0	0.1	0.1	0.1	-0.4	-0.1	0.3
Reaction time number correct	0.5	0.8	1.6	-1.3	0.6	-0.8	-0.6
Reaction time mean minus median	1.5	2.0	2.8	1.7	-1.2	1.5	1.3
Reaction time mean minus median AUC	0.7	0.9	1.1	0.9	-0.9	1.0	0.9
Reaction time num false alarms	0.3	0.4	0.5	-0.7	0.6	-0.3	-0.7
Reaction time num false alarms AUC	0.6	0.9	1.6	-1.2	0.9	-0.6	-0.9
Reaction time trials correct on left	0.5	0.8	1.6	-1.3	0.6	-0.8	-0.6
Reaction time trials on left	0.5	0.8	1.7	-1.3	0.6	-0.8	-0.6
Reaction time mean	0.6	0.9	1.2	1.1	-0.8	1.0	0.8
Reaction time mean AUC	0.4	0.5	0.8	0.9	-0.6	0.7	0.6
Median of all reaction times	0.6	0.8	1.0	1.0	-0.8	0.9	0.9
Reaction time omissions	0.2	0.3	0.4	0.2	-0.6	0.7	0.6
Reaction time false alarm rate	0.1	0.2	0.3	-0.4	0.5	-0.1	-0.6
Reaction time premature initiation rate	0.0	0.1	0.1	0.3	-0.1	0.4	0.1
Reaction time premature initiations	0.0	0.0	0.1	-0.2	0.0	0.0	-0.0
Std. dev. reaction times	2.4	3.4	4.0	1.8	-1.7	2.0	1.8
Reaction time trials completed	0.5	0.8	1.7	-1.3	0.6	-0.8	-0.6
Reaction time trials AUC	0.6	0.9	1.7	-1.3	0.7	-0.9	-0.6
Social response proportion	1.1	1.1	1.7	-1.1	0.9	-1.3	-1.0
Social responses	1.7	2.1	4.1	-2.0	1.2	-1.2	-1.2
Social time	0.3	0.3	1.0	-1.0	0.0	-0.6	-0.0
Conditioned locomotion	0.2	0.2	0.5	-0.7	0.3	-0.4	-0.3
Cocaine response after cond. corrected	0.3	0.3	0.4	0.3	-0.7	0.4	0.7
Cocaine response after cond. not corrected	0.1	0.1	0.2	-0.4	-0.1	-0.2	0.1
Cocaine response before conditioning	3.1	3.7	4.2	-1.9	1.9	-2.0	-1.9
Saline control response	1.2	1.6	1.9	-1.1	1.4	-1.2	-1.4
Condit. Reinf. active minus inactive responses	0.6	0.7	1.2	-0.4	1.1	-0.5	-1.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.5	0.0	0.6	-0.0
Condit. Reinf. active responses	1.2	1.7	2.2	-1.1	1.5	-1.0	-1.5
Condit. Reinf. inactive responses	2.1	2.7	2.9	-1.7	1.6	-1.6	-1.6
Condit. Reinf. lever presses	1.7	2.3	3.4	-1.2	1.8	-1.0	-1.8
Condit. Reinf. lever reinforcers received	1.7	2.4	3.0	-1.3	1.7	-1.3	-1.7
Pavlov. Cond. lever latency	1.3	1.7	2.5	0.9	-1.6	1.1	1.6
Pavlov. Cond. magazine entry latency	0.5	0.5	0.7	-0.4	0.8	-0.8	-0.8
Pavlov. Cond. change in total contacts	0.9	1.3	1.8	-0.8	1.4	-0.9	-1.4
Pavlov. Cond. index score	1.0	1.4	2.0	-0.6	1.4	-1.0	-1.4
Pavlov. Cond. latency score	1.3	1.6	2.4	-0.7	1.6	-1.1	-1.6
Pavlov. Cond. lever contacts	0.7	1.0	1.6	-0.6	1.3	-0.8	-1.3
Pavlov. Cond. magazine entry number	0.4	0.5	0.6	0.3	-0.8	0.7	0.8
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.0	-1.0	0.9	-0.8	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.4	-0.4	1.2	-0.8	-1.2
Pavlov. Cond. response bias	0.3	0.4	0.8	-0.1	0.9	-0.5	-0.9
Conditioned reinforcement - actives	1.0	1.0	1.2	-1.1	1.1	-0.5	-1.1
Conditioned reinforcement - inactives	0.7	0.8	1.0	-1.0	0.9	-0.7	-0.9
Conditioned locomotion	0.0	0.1	0.2	-0.4	0.1	0.2	-0.1
Intermittent access intake day 1-15 change	0.1	0.1	0.2	0.5	0.1	0.3	-0.1
Intermittent access intake escalation	0.1	0.0	0.1	0.3	0.2	0.0	-0.3
Intermittent access intake escalation 2	0.1	0.1	0.2	0.4	0.0	0.3	-0.1
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	0.6	-0.3	0.4	0.3
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.5	-0.2	0.3	0.2
Intermitt. access escalation Index	4.5	4.0	5.5	-2.0	1.8	-2.3	-1.8
Intermittent access day 1 total infusions	0.0	0.0	0.2	-0.4	0.1	-0.1	-0.1
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.2	0.3	-0.1	-0.3
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.4	-0.7	0.6	-0.4	-0.6
Intermittent access total infusions	0.9	1.0	1.4	-1.2	1.0	-0.8	-1.0
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.1	-0.2	0.2	0.3
Intermittent access day 15 total locomotion	0.7	0.7	0.9	-0.9	0.9	-0.7	-0.9
Intermittent access total locomotion	0.0	0.0	0.2	-0.4	0.0	-0.0	-0.0
Intermittent access standard deviation	0.6	0.7	0.9	-0.7	0.9	-0.6	-1.0
Cocaine induced anxiety	5.3	6.1	6.6	2.4	-2.6	2.4	2.6
Post-drug Anxiety	4.3	4.8	5.1	2.2	-2.2	2.0	2.2
Baseline Anxiety	0.5	0.5	0.7	-0.5	0.8	-0.8	-0.8
Lifetime Intake	0.9	1.0	1.3	-1.1	1.0	-0.8	-1.0
Incentive Sensitization - Responses	1.4	1.4	2.1	1.0	-1.1	1.4	1.1
Incentive Sensitization - Breakpoint	0.9	0.9	1.4	0.7	-0.8	1.2	0.9
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	0.4	-0.5	0.5	0.5
Progressive ratio test 1 breakpoint	0.3	0.3	0.3	0.5	-0.6	0.6	0.6
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.6	0.7	-0.7	0.7	0.8
Progressive ratio test 2 active lever presses	0.1	0.2	0.3	0.2	-0.4	0.5	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.2	-0.5	0.6	0.5
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.6	0.5	-0.5	0.8	0.5
Total sessions with >9 infusions	0.1	0.1	0.2	0.3	-0.3	0.5	0.4
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.1	-0.2	-0.1	0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.3	0.2	-0.4	-0.2
Short access day 1 total infusions	1.2	1.3	1.5	-1.2	1.1	-1.2	-1.1
Short access day 10 total infusions	0.6	0.6	0.8	-0.9	0.8	-0.7	-0.8
Short access total infusions	0.3	0.3	0.5	-0.7	0.6	-0.5	-0.5
Short access day 1 locomotion	0.0	0.0	0.0	-0.1	0.2	-0.0	-0.2
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.0
Short access total locomotion	0.0	0.0	0.1	0.1	-0.2	0.3	0.3
Compulsive drug intake	2.2	2.2	3.1	-1.4	1.4	-1.7	-1.4
One hour access (0.3 mA shock)	0.8	1.0	1.1	-0.9	1.0	-0.9	-1.1
One hour access (shock baseline)	0.3	0.3	0.5	-0.7	0.6	-0.4	-0.6
Number of responses in last shaping day	2.7	2.8	3.2	1.5	-1.7	1.7	1.8
Context. condit. distance diff. score	0.0	0.0	0.1	-0.1	0.3	-0.1	-0.3
Locomotion velocity, session 1	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0
Locomotion distance, session 1	0.7	0.9	1.6	1.2	-0.7	1.1	0.7
Locomotion velocity, session 2	0.5	0.5	0.9	0.9	-0.5	0.9	0.5
Locomotion distance, session 2	0.4	0.6	1.1	0.9	-0.6	1.0	0.6
Locomotion velocity, session 3	0.3	0.4	0.4	-0.7	0.5	-0.6	-0.5
Locomotion distance, session 3	0.1	0.1	0.1	0.3	-0.2	0.2	0.2
Stereotopy head waving bouts, day 3	0.1	0.2	0.4	-0.6	0.4	-0.2	-0.4
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.0	-0.2	0.3	0.2
Locomotion velocity, session 7	1.6	1.7	2.0	1.4	-1.3	1.3	1.3
Locomotion distance, session 7	2.5	3.2	5.0	2.2	-1.6	1.7	1.6
Stereotopy head waving bouts, day 7	1.8	2.1	2.6	1.1	-1.6	1.4	1.6
Stereotopy head waving duration, day 7	0.8	1.0	1.4	0.5	-1.2	1.0	1.2
Locomotion velocity, session 8	0.0	0.0	0.0	0.2	-0.0	-0.1	0.0
Locomotion distance, session 8	0.2	0.3	0.4	0.7	-0.4	0.6	0.4
Degree of sensitization distance	1.6	1.6	2.5	1.6	-1.1	1.2	1.1
Degree of sensitization stereotypy	2.9	3.1	3.7	1.4	-1.9	1.7	1.9
Condit. Reinf. active minus inactive responses	0.3	0.4	0.5	-0.3	0.6	-0.7	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	0.2	-0.4	-0.2
Condit. Reinf. active responses	1.5	1.8	2.1	-1.2	1.5	-1.3	-1.5
Condit. Reinf. inactive responses	1.0	1.2	1.5	-1.1	1.2	-0.8	-1.2
Incentive salience index mean	0.4	0.4	0.5	-0.5	0.7	-0.7	-0.7
Condit. Reinf. lever presses	0.7	1.0	1.1	-1.0	1.0	-0.9	-1.0
Time in familiar zone, hab. session 1	1.5	1.4	2.1	1.4	-1.0	1.3	1.0
Time in novel zone, hab. session 1	2.5	2.5	3.1	-1.8	1.4	-1.7	-1.4
Total zone transitions, hab. session 1	2.1	3.0	4.1	2.0	-1.4	1.9	1.4
Total locomotion distance, hab. session 1	1.0	1.5	2.1	1.4	-1.0	1.5	1.0
Locomotion velocity, hab. session 1	0.8	1.1	1.8	1.4	-0.8	1.2	0.8
Time in familiar zone, hab. session 2	0.0	0.1	0.2	0.4	0.1	-0.1	-0.1
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.4	0.3	-0.0	-0.3
Total zone transitions, hab. session 2	0.3	0.4	0.7	0.8	-0.4	0.9	0.4
Total locomotion distance, hab. session 2	0.3	0.4	0.7	0.6	-0.4	0.8	0.4
Locomotion velocity, hab. session 2	0.3	0.4	0.7	0.7	-0.4	0.8	0.4
Novel to familiar place preference ratio	0.3	0.4	0.5	0.2	-0.7	0.7	0.7
Novelty place preference	0.1	0.1	0.3	0.1	-0.4	0.5	0.4
Time in novel zone, NPP test	0.0	0.0	0.1	-0.2	-0.1	0.2	0.1
Total zone transitions, NPP test	0.4	0.6	1.1	0.9	-0.6	1.1	0.6
Total locomotion distance, NPP test	0.6	0.9	1.5	0.9	-0.8	1.2	0.8
Locomotion velocity, NPP test	1.0	1.4	2.3	1.1	-1.1	1.5	1.1
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.3	0.3	-0.4	-0.3
Pavlov. Cond. magazine entry latency	0.5	0.7	0.8	0.7	-0.9	0.9	0.9
Pavlov. Cond. change in total contacts	0.5	0.5	0.7	0.8	-0.6	0.8	0.6
Pavlov. Cond. index score	0.1	0.1	0.2	0.3	-0.3	0.4	0.3
Pavlov. Cond. latency score	0.1	0.2	0.2	0.3	-0.4	0.5	0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.2	0.0	-0.1	-0.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.3	-0.3	0.2	0.3
Pavlov. Cond. intertrial magazine entries	1.7	2.0	3.3	-1.8	1.3	-1.1	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.1	0.3	-0.2	0.3	0.2
Pavlov. Cond. response bias	0.2	0.2	0.2	-0.4	0.5	-0.4	-0.5
Bone: apparent density	0.7	1.1	1.9	-0.5	1.1	-1.4	-1.1
Bone surface	0.7	1.2	2.1	-0.9	1.0	-1.4	-1.0
Bone volume	1.3	2.1	3.3	-1.1	1.4	-1.8	-1.4
Bone: connectivity density	1.0	1.5	2.8	-0.9	1.1	-1.7	-1.1
Bone: cortical apparent density	1.4	1.8	2.1	1.4	-1.3	1.2	1.3
Bone: cortical area	2.8	4.3	4.9	-1.9	2.2	-1.9	-2.2
Bone: cortical porosity	1.3	1.4	1.6	-1.3	1.2	-1.1	-1.2
Bone: cortical porosity	1.9	2.0	2.3	-1.5	1.4	-1.3	-1.4
Bone: cortical thickness	1.7	2.8	3.5	-1.4	1.9	-1.5	-1.9
Bone: cortical thickness	0.3	0.4	0.5	-0.6	0.7	-0.4	-0.7
Bone: cortical tissue density	1.5	1.9	2.2	1.5	-1.4	1.2	1.4
Bone: elastic displacement	0.0	0.1	0.2	-0.1	0.0	-0.4	-0.0
Bone: elastic work	0.7	0.9	1.6	-0.6	0.9	-1.3	-0.9
Bone: endosteal estimation	0.1	0.1	0.3	-0.5	0.2	-0.3	-0.2
Bone: endosteal perimeter	0.0	0.0	0.0	-0.2	0.1	-0.0	-0.1
Bone: final force	0.8	1.2	1.9	-0.7	1.4	-0.8	-1.4
Bone: final moment	0.7	1.2	1.8	-0.7	1.4	-0.8	-1.4
Bone: marrow area	0.1	0.2	0.4	-0.6	0.3	-0.4	-0.3
Bone: maximum diameter	5.4	9.8	10.3	-3.0	3.2	-3.1	-3.2
Bone: maximum force	0.4	0.7	1.0	-0.5	1.0	-0.7	-1.0
Bone: maximum moment	0.4	0.7	1.0	-0.6	1.0	-0.7	-1.0
Bone: minimum diameter	0.4	0.7	0.9	-0.6	0.9	-0.8	-0.9
Bone: periosteal estimation	0.9	1.8	2.0	-1.4	1.3	-1.3	-1.3
Bone: periosteal perimeter	0.2	0.4	0.5	-0.6	0.7	-0.5	-0.7
Bone: post-yield work	0.2	0.3	0.5	-0.5	0.5	-0.7	-0.5
Bone: stiffness	0.3	0.5	0.7	-0.4	0.9	-0.4	-0.9
Bone: tissue strength	0.2	0.2	0.4	-0.0	0.6	-0.4	-0.6
Bone: trabecular number	0.4	0.7	1.0	-0.6	0.8	-1.0	-0.8
Bone: trabecular spacing	0.2	0.2	0.3	0.1	-0.5	0.5	0.5
Bone: trabecular thickness	2.7	3.2	4.9	-1.3	1.8	-2.2	-1.8
Bone: trabecular tissue density	0.2	0.2	0.4	-0.0	-0.5	0.6	0.5
Breakpoint value in progressive ratio session	0.9	1.0	1.2	-0.9	1.0	-1.1	-1.0
Distance traveled before self-admin	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.3
Distance traveled after self-admin	0.5	0.5	0.7	0.8	-0.8	0.3	0.8
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	-0.3	0.5	-0.8	-0.5
Delta time in open arm before/after self-admin	4.9	4.7	4.8	2.2	-2.2	2.1	2.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.2	-0.2	0.4	0.2
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.2	-0.0	0.4	-0.1
Active lever presses in extinction session 6	0.3	0.3	0.4	-0.6	0.5	-0.5	-0.6
Delta distance traveled before/after self-admin	0.0	0.0	0.1	0.2	-0.3	-0.1	0.3
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.3	-0.5	-0.0	0.5
Time in closed arm before self-admin	2.1	2.4	2.7	1.4	-1.6	1.6	1.6
Time in closed arm after self-admin	0.0	0.0	0.0	0.2	-0.2	0.0	0.1
Time in open arm before self-admin	1.5	1.6	1.8	-1.3	1.2	-1.3	-1.2
Time in open arm after self-admin	0.5	0.6	0.7	0.6	-0.8	0.7	0.8
Sum of active levers in priming session hrs 5-6	2.0	2.0	2.3	-1.2	1.5	-1.4	-1.5
Time to tail flick, vehicle, before self-admin	2.7	2.8	3.4	-1.6	1.8	-1.3	-1.8
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.9	0.3	-0.5	1.0	0.5
Time to tail flick, test, before self-admin	1.1	1.1	1.5	1.2	-1.2	0.5	1.2
Time to tail flick, test, after self-admin	0.9	0.9	1.0	0.9	-1.0	0.8	1.0
Delta time to tail flick, vehicle, before/after SA	3.5	3.4	3.8	1.6	-1.8	2.0	1.9
Delta time to tail flick, test, before/after SA	1.2	1.1	1.6	-1.3	1.1	-0.6	-1.0
Ambulatory time before self-admin	0.4	0.4	0.4	-0.5	0.6	-0.6	-0.7
Ambulatory time after self-admin	0.3	0.3	0.5	0.4	-0.7	0.2	0.7
Total heroin consumption	0.6	0.8	0.9	-0.9	0.8	-0.9	-0.9
Area under the delay curve	1.5	1.6	1.7	1.3	-1.3	1.1	1.3
Delay disc. indifference point, 0s delay	1.5	1.6	1.8	1.2	-1.2	1.4	1.2
Delay disc. indifference point, 16s delay	1.5	1.5	1.8	1.3	-1.2	1.2	1.2
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.0	0.0	-0.2	-0.0
Delay disc. indifference point, 24s delay	4.3	4.2	5.0	2.2	-2.0	2.0	1.9
Delay disc. indifference point, 4s delay	0.2	0.3	0.3	0.6	-0.6	0.2	0.5
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	0.5	-0.7	0.4	0.7
Delay discount exponential model param	1.4	1.5	1.7	-1.3	1.3	-1.0	-1.3
Delay discount hyperbolic model param	1.0	1.0	1.2	-1.1	1.1	-0.8	-1.1
Fecal boli incidents, locomotor time 1	0.2	0.2	0.2	0.5	-0.5	0.5	0.4
Change in fecal boli incidents, locomotor task	0.4	0.4	0.5	-0.5	0.7	-0.6	-0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.5	-0.1	-0.2	0.1
Bouts of movement, locomotor time 1	0.1	0.2	0.4	0.7	0.0	-0.5	-0.1
Total resting periods, locomotor time 1	0.2	0.2	0.5	0.7	-0.1	-0.5	0.1
Rest time, locomotor task time 1	0.7	0.8	1.5	-0.5	0.8	-1.2	-0.9
Distance moved, locomotor task time 1	1.9	2.0	3.3	1.1	-1.3	1.8	1.3
Vertical activity count, locomotor time 1	3.3	3.5	4.7	1.5	-1.9	2.2	1.9
Time >=10cm from walls, locomotor time 2	1.0	1.0	1.4	0.8	-1.2	0.9	1.2
Bouts of movement, locomotor time 2	5.3	5.7	7.5	2.7	-2.3	2.1	2.3
Total resting periods, locomotor time 2	3.6	3.9	5.4	2.3	-1.9	1.6	1.9
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	-0.1	-0.1	0.1
Distance moved, locomotor task time 2	0.2	0.3	0.4	0.3	-0.5	0.7	0.5
Vertical activity count, locomotor time 2	1.1	1.2	1.4	0.8	-1.2	1.2	1.2
Weight adjusted by age	3.6	4.1	5.0	-1.7	2.1	-2.2	-2.1
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.3	-0.1	0.1	0.1
Locomotion in novel chamber	0.1	0.1	0.2	-0.3	0.1	0.5	-0.1
Locomotion in novel chamber post-restriction	0.3	0.3	0.4	-0.5	0.5	-0.6	-0.5
Progressive ratio	0.4	0.4	0.8	-0.9	0.6	-0.5	-0.6
Food seeking constrained by brief footshock	2.2	2.7	3.4	-1.3	1.7	-1.8	-1.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.2	0.3	-0.5	-0.3
Run reversals in cocaine runway, females	0.6	0.6	0.7	0.8	-0.8	0.7	0.8
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.5	0.4	-0.6	-0.3
Latency to leave start box in cocaine runway	0.6	0.7	0.9	-1.0	0.8	-0.7	-0.8
Latency to leave start box in cocaine runway, F	0.2	0.3	0.3	-0.4	0.6	-0.5	-0.5
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.7	0.4	-0.2	-0.4
Cd content in liver	1.0	1.0	2.4	-1.5	0.6	-1.1	-0.6
Co content in liver	4.4	5.2	5.8	2.1	-2.4	2.2	2.4
Cu content in liver	0.0	0.0	0.1	-0.0	-0.0	0.3	0.0
Fe content in liver	0.0	0.0	0.1	-0.3	-0.0	-0.3	0.0
K content in liver	3.8	3.8	4.9	1.1	-2.2	2.1	2.2
Mg content in liver	6.4	6.6	8.4	1.6	-2.9	2.7	2.9
Mn content in liver	1.7	1.9	2.9	1.2	-1.3	1.7	1.3
Na content in liver	2.4	2.5	3.4	0.7	-1.7	1.8	1.7
Rb content in liver	0.0	0.1	0.2	-0.4	-0.2	0.1	0.2
Se content in liver	2.8	3.4	3.9	1.7	-2.0	1.7	2.0
Sr content in liver	0.1	0.1	0.2	-0.0	0.5	-0.3	-0.5
Zn content in liver	0.1	0.2	0.6	-0.8	0.0	-0.2	-0.0