# | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Adipose | alternative TSS | ENSRNOT00000114273 | 0.0578 | 0.0393 | 3.1e-06 | 0.057 | 0.044 | 0.047 | 0.051 | 6.2e-07 | 1.1e-05 | 5.8e-06 | 2.3e-06 |
2 | Adipose | alternative TSS | ENSRNOT00000118712 | 0.0646 | 0.0443 | 1.3e-06 | 0.060 | 0.046 | 0.048 | 0.055 | 2.9e-07 | 6.5e-06 | 4.3e-06 | 1.0e-06 |
3 | Adipose | gene expression | ENSRNOG00000001681 | 0.1500 | 0.0870 | 1.4e-11 | 0.073 | 0.086 | 0.091 | 0.094 | 1.7e-08 | 9.2e-10 | 2.6e-10 | 1.5e-10 |
4 | Adipose | intron excision ratio | chr11:33825581:33827030 | 0.0964 | 0.0529 | 1.5e-11 | 0.092 | 0.081 | 0.076 | 0.091 | 2.2e-10 | 2.6e-09 | 8.9e-09 | 2.8e-10 |
5 | Adipose | intron excision ratio | chr11:33826532:33827030 | 0.2132 | 0.0850 | 0.0e+00 | 0.249 | 0.246 | 0.248 | 0.247 | 2.3e-27 | 5.0e-27 | 2.3e-27 | 3.5e-27 |
6 | BLA | mRNA stability | ENSRNOG00000001681 | 0.1400 | 0.0720 | 1.5e-07 | 0.121 | 0.122 | 0.095 | 0.103 | 5.3e-07 | 4.7e-07 | 9.0e-06 | 3.6e-06 |
7 | Brain | gene expression | ENSRNOG00000001681 | 0.0280 | 0.0230 | 9.4e-03 | 0.015 | 0.007 | 0.008 | 0.011 | 1.4e-02 | 6.5e-02 | 5.2e-02 | 3.0e-02 |
8 | Brain | mRNA stability | ENSRNOG00000001681 | 0.0565 | 0.0360 | 1.7e-05 | 0.043 | 0.036 | 0.041 | 0.045 | 7.7e-05 | 2.4e-04 | 1.0e-04 | 5.1e-05 |
9 | Eye | intron excision ratio | chr11:33826532:33827030 | 0.3360 | 0.2010 | 9.8e-03 | 0.014 | -0.008 | -0.018 | -0.012 | 2.0e-01 | 4.4e-01 | 7.8e-01 | 5.3e-01 |
10 | IL | intron excision ratio | chr11:33825581:33827030 | 0.2880 | 0.2460 | 5.1e-03 | 0.028 | 0.112 | 0.008 | 0.064 | 7.2e-02 | 1.2e-03 | 2.0e-01 | 1.3e-02 |
11 | IL | intron excision ratio | chr11:33826532:33827030 | 0.2960 | 0.2650 | 6.6e-03 | 0.018 | 0.102 | 0.005 | 0.042 | 1.2e-01 | 2.0e-03 | 2.4e-01 | 3.5e-02 |
12 | LHb | mRNA stability | ENSRNOG00000001681 | 0.1380 | 0.1000 | 4.7e-03 | 0.041 | 0.112 | 0.089 | 0.083 | 3.9e-02 | 1.3e-03 | 4.0e-03 | 5.2e-03 |
13 | Liver | intron excision ratio | chr11:33820891:33825432 | 0.1076 | 0.0600 | 7.8e-12 | 0.091 | 0.087 | 0.089 | 0.093 | 2.5e-10 | 7.4e-10 | 3.9e-10 | 1.6e-10 |
14 | Liver | intron excision ratio | chr11:33825581:33827030 | 0.1520 | 0.0734 | 0.0e+00 | 0.147 | 0.145 | 0.145 | 0.117 | 5.4e-16 | 7.8e-16 | 8.4e-16 | 6.2e-13 |
15 | Liver | intron excision ratio | chr11:33826532:33827030 | 0.2496 | 0.0909 | 0.0e+00 | 0.304 | 0.304 | 0.310 | 0.314 | 3.2e-34 | 3.2e-34 | 6.1e-35 | 1.6e-35 |
16 | Liver | mRNA stability | ENSRNOG00000001681 | 0.0705 | 0.0393 | 2.7e-09 | 0.056 | 0.072 | 0.061 | 0.065 | 6.9e-07 | 2.0e-08 | 2.5e-07 | 9.9e-08 |
17 | NAcc | mRNA stability | ENSRNOG00000001681 | 0.0916 | 0.0536 | 1.3e-07 | 0.084 | 0.088 | 0.096 | 0.092 | 8.1e-07 | 4.2e-07 | 1.4e-07 | 2.2e-07 |
18 | OFC | intron excision ratio | chr11:33826532:33827030 | 0.1312 | 0.0949 | 9.5e-03 | 0.112 | 0.042 | 0.058 | 0.032 | 1.3e-03 | 3.6e-02 | 1.7e-02 | 6.0e-02 |
19 | PL | gene expression | ENSRNOG00000001681 | 0.1226 | 0.0760 | 1.9e-07 | 0.095 | 0.085 | 0.082 | 0.083 | 1.1e-07 | 4.9e-07 | 7.6e-07 | 7.3e-07 |
20 | PL | mRNA stability | ENSRNOG00000001681 | 0.1168 | 0.0609 | 2.5e-10 | 0.097 | 0.133 | 0.129 | 0.126 | 8.0e-08 | 2.9e-10 | 5.5e-10 | 8.4e-10 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tibialis anterior weight | 6.6 | 22.6 | 35.1 | -4.7 | 4.7 | 3.4 | -4.7 | 4.9 | -5.1 | 4.5 | -5.9 | 5.6 | 1.0 | -0.7 | -5.6 | -4.8 | -4.8 | 4.8 | -5.5 | -5.4 | 4.7 | 4.8 | -5.6 |
Pavlov. Cond. intertrial magazine entries | 6.5 | 7.8 | 11.6 | -2.7 | 2.7 | 2.5 | -2.7 | 3.3 | -3.2 | 2.9 | -2.4 | 2.0 | -1.7 | 1.9 | -1.5 | -3.4 | -2.8 | 3.2 | -3.0 | -3.1 | 3.4 | 3.3 | -2.8 |
Times rat made contact with spout | 4.9 | 5.6 | 10.7 | 1.6 | -1.6 | -1.9 | 1.7 | -2.5 | 2.6 | -2.4 | 2.9 | -2.6 | -1.9 | 1.7 | 3.3 | 2.2 | 1.7 | -2.1 | 2.7 | 2.8 | -2.5 | -2.4 | 3.0 |
Glucose | 4.6 | 7.0 | 8.7 | -2.8 | 2.8 | 2.8 | -2.9 | 2.8 | -2.9 | 2.9 | -2.7 | 2.6 | -0.8 | 0.9 | -2.0 | -2.6 | -2.9 | 2.9 | -2.9 | -2.8 | 2.8 | 2.8 | -2.8 |
Locomotion velocity, session 3 | 4.5 | 5.2 | 9.7 | -2.3 | 2.3 | 3.0 | -2.3 | 2.5 | -2.5 | 3.1 | -1.8 | 1.9 | -1.4 | 1.5 | -1.0 | -2.3 | -2.4 | 2.4 | -2.3 | -2.3 | 2.6 | 2.5 | -2.2 |
Locomotor activity | 4.0 | 6.4 | 9.4 | 2.8 | -2.8 | -1.8 | 2.7 | -2.5 | 2.7 | -2.2 | 3.1 | -3.0 | 0.3 | -0.4 | 2.5 | 2.6 | 2.8 | -2.6 | 2.9 | 2.7 | -2.5 | -2.6 | 2.8 |
Stereotopy head waving bouts, day 7 | 4.0 | 4.5 | 6.4 | -2.3 | 2.3 | 2.0 | -2.2 | 2.4 | -2.3 | 2.3 | -1.5 | 1.4 | -2.1 | 2.2 | -0.6 | -2.5 | -2.2 | 2.4 | -2.1 | -2.1 | 2.5 | 2.4 | -1.8 |
Stereotopy head waving duration, day 7 | 3.8 | 4.6 | 6.6 | -2.3 | 2.3 | 2.6 | -2.1 | 2.5 | -2.4 | 2.3 | -1.5 | 1.3 | -1.8 | 1.9 | -0.5 | -2.3 | -2.1 | 2.4 | -2.2 | -2.2 | 2.6 | 2.5 | -2.0 |
Na content in liver | 3.8 | 4.1 | 5.6 | -2.1 | 2.1 | 2.3 | -1.9 | 2.2 | -2.3 | 2.3 | -2.0 | 1.9 | -0.6 | 0.7 | -1.4 | -2.0 | -1.9 | 2.1 | -2.2 | -2.4 | 2.2 | 2.2 | -2.2 |
Extensor digitorum longus weight | 3.6 | 14.4 | 22.9 | -3.7 | 3.7 | 2.8 | -3.6 | 3.9 | -4.2 | 3.7 | -4.8 | 4.5 | 0.7 | -0.5 | -4.4 | -3.9 | -3.7 | 3.8 | -4.4 | -4.3 | 3.9 | 3.8 | -4.5 |
Degree of sensitization stereotypy | 3.5 | 3.8 | 6.0 | -2.1 | 2.1 | 2.5 | -1.9 | 2.3 | -2.3 | 2.1 | -1.8 | 1.6 | -1.0 | 1.1 | -1.0 | -1.9 | -1.9 | 2.1 | -2.1 | -2.1 | 2.3 | 2.3 | -2.0 |
Reaction time num false alarms AUC | 3.1 | 4.4 | 6.0 | 2.1 | -2.1 | -2.3 | 2.0 | -2.1 | 2.4 | -2.1 | 2.4 | -2.3 | 0.1 | -0.2 | 1.9 | 1.9 | 2.0 | -2.2 | 2.4 | 2.4 | -2.3 | -2.2 | 2.4 |
Locomotion distance, session 7 | 3.0 | 3.8 | 5.6 | 2.2 | -2.2 | -1.4 | 2.0 | -2.2 | 2.3 | -1.6 | 2.0 | -1.5 | 0.7 | -0.8 | 1.5 | 2.4 | 1.8 | -2.3 | 2.2 | 2.3 | -2.3 | -2.2 | 2.1 |
Total locomotion distance, hab. session 2 | 3.0 | 4.0 | 8.1 | 1.7 | -1.7 | -1.3 | 1.7 | -2.5 | 2.4 | -2.1 | 1.7 | -1.4 | 0.9 | -1.0 | 1.4 | 2.8 | 1.7 | -2.4 | 2.2 | 2.4 | -2.5 | -2.5 | 2.1 |
Bone: minimum diameter | 3.0 | 5.5 | 8.5 | -2.0 | 2.0 | 2.6 | -2.1 | 2.5 | -2.7 | 2.9 | -2.6 | 2.4 | 0.4 | -0.3 | -2.4 | -2.2 | -2.1 | 2.4 | -2.7 | -2.7 | 2.6 | 2.6 | -2.8 |
Reaction time false alarm rate | 2.9 | 4.2 | 6.3 | 2.2 | -2.2 | -2.5 | 2.1 | -2.1 | 2.3 | -2.0 | 2.3 | -2.2 | 0.3 | -0.4 | 1.6 | 1.6 | 2.1 | -2.1 | 2.3 | 2.2 | -2.1 | -2.1 | 2.3 |
Locomotion velocity, session 8 | 2.9 | 3.4 | 6.2 | -1.6 | 1.6 | 2.4 | -1.7 | 2.3 | -2.1 | 2.5 | -1.3 | 1.2 | -1.0 | 1.1 | -0.8 | -1.9 | -1.8 | 2.0 | -1.9 | -2.1 | 2.3 | 2.3 | -1.8 |
Right kidney weight | 2.8 | 8.1 | 10.7 | 3.2 | -3.2 | -2.2 | 3.2 | -3.1 | 3.0 | -3.0 | 2.8 | -2.8 | 1.4 | -1.6 | 2.0 | 3.3 | 3.1 | -3.1 | 3.0 | 3.0 | -3.0 | -3.1 | 2.8 |
Locomotion velocity, hab. session 2 | 2.8 | 3.8 | 7.9 | 1.5 | -1.5 | -1.2 | 1.5 | -2.5 | 2.3 | -2.0 | 1.7 | -1.3 | 0.8 | -0.9 | 1.4 | 2.8 | 1.6 | -2.3 | 2.1 | 2.4 | -2.5 | -2.5 | 2.1 |
Delta time to tail flick, vehicle, before/after SA | 2.7 | 2.6 | 4.6 | -1.3 | 1.3 | 2.1 | -1.1 | 1.5 | -1.8 | 1.5 | -2.1 | 2.0 | 1.3 | -1.2 | -2.0 | -0.8 | -1.1 | 1.2 | -1.9 | -2.0 | 1.5 | 1.6 | -2.1 |
Sr content in liver | 2.7 | 2.5 | 3.3 | 1.7 | -1.7 | -1.3 | 1.8 | -1.6 | 1.7 | -1.6 | 1.8 | -1.6 | 0.2 | -0.3 | 1.5 | 1.6 | 1.8 | -1.7 | 1.8 | 1.7 | -1.6 | -1.6 | 1.7 |
Degree of sensitization distance | 2.6 | 2.6 | 3.7 | 1.7 | -1.7 | -1.1 | 1.5 | -1.7 | 1.8 | -1.4 | 1.9 | -1.7 | -0.0 | -0.1 | 1.7 | 1.8 | 1.5 | -1.7 | 1.9 | 1.9 | -1.7 | -1.7 | 1.9 |
Light reinforcement 2 | 2.5 | 3.2 | 5.4 | -1.7 | 1.7 | 2.0 | -1.8 | 1.5 | -2.0 | 1.7 | -2.2 | 2.0 | 1.1 | -1.0 | -2.2 | -1.3 | -1.8 | 1.6 | -2.1 | -1.9 | 1.8 | 1.5 | -2.3 |
Left kidney weight | 2.3 | 6.5 | 10.4 | 2.7 | -2.7 | -2.2 | 2.6 | -2.9 | 2.7 | -3.1 | 1.9 | -1.8 | 1.9 | -2.0 | 1.3 | 3.2 | 2.5 | -2.9 | 2.5 | 2.7 | -3.0 | -3.0 | 2.3 |
Reaction time num false alarms | 2.3 | 3.2 | 5.1 | 1.8 | -1.8 | -2.1 | 1.7 | -1.7 | 2.0 | -1.7 | 2.2 | -2.1 | -0.4 | 0.3 | 1.8 | 1.4 | 1.7 | -1.8 | 2.1 | 2.0 | -1.8 | -1.7 | 2.2 |
Time to tail flick, vehicle, before self-admin | 2.3 | 2.3 | 5.7 | 1.3 | -1.3 | -2.4 | 1.1 | -1.4 | 1.6 | -1.4 | 2.1 | -1.9 | -1.0 | 1.0 | 1.7 | 0.5 | 1.3 | -1.1 | 1.8 | 1.7 | -1.2 | -1.4 | 1.9 |
Time to tail flick, test, after self-admin | 2.3 | 2.4 | 3.5 | 1.8 | -1.8 | -1.3 | 1.8 | -1.9 | 1.5 | -1.7 | 1.1 | -0.6 | 1.8 | -1.9 | 0.3 | 1.7 | 1.8 | -1.8 | 1.3 | 1.3 | -1.5 | -1.6 | 1.1 |
Intermitt. access day 1 inactive lever presses | 2.2 | 2.4 | 6.3 | 1.5 | -1.5 | -1.1 | 1.3 | -1.2 | 1.5 | -1.1 | 2.5 | -2.5 | -0.9 | 0.8 | 2.1 | 0.9 | 1.4 | -1.3 | 1.7 | 1.7 | -1.0 | -1.2 | 1.8 |
Epididymis fat weight | 2.1 | 4.9 | 9.6 | -1.5 | 1.5 | 2.5 | -1.3 | 1.7 | -2.4 | 2.1 | -3.0 | 2.7 | 2.1 | -2.0 | -3.1 | -1.4 | -1.4 | 1.7 | -2.6 | -2.5 | 2.0 | 1.9 | -3.0 |
Bone surface | 2.1 | 3.7 | 6.1 | -1.8 | 1.8 | 2.1 | -1.7 | 1.7 | -2.0 | 2.1 | -2.5 | 2.4 | 1.0 | -0.9 | -2.4 | -1.4 | -1.7 | 1.7 | -2.2 | -2.1 | 1.8 | 1.7 | -2.4 |
Diff in mean of infusions in LGA sessions | 2.1 | 2.3 | 5.8 | -1.8 | 1.8 | 2.4 | -1.9 | 1.4 | -1.5 | 1.7 | -0.8 | 0.6 | -1.7 | 1.8 | 0.2 | -1.1 | -1.8 | 1.6 | -1.3 | -1.0 | 1.6 | 1.7 | -1.1 |
Time in closed arm after self-admin | 2.1 | 2.2 | 9.8 | 1.2 | -1.2 | -1.3 | 1.0 | -1.6 | 0.9 | -1.4 | -0.6 | 0.9 | 3.1 | -3.1 | -1.5 | 1.4 | 0.9 | -1.4 | 0.4 | 0.5 | -1.4 | -1.5 | 0.1 |
Mean time between licks in bursts | 2.0 | 2.8 | 4.1 | 1.6 | -1.6 | -1.8 | 1.6 | -1.8 | 1.9 | -1.4 | 1.9 | -1.8 | -0.3 | 0.3 | 1.6 | 1.4 | 1.6 | -1.6 | 1.9 | 1.9 | -1.9 | -1.9 | 2.0 |
Bone: trabecular spacing | 2.0 | 2.5 | 3.6 | 1.7 | -1.7 | -1.4 | 1.7 | -1.6 | 1.7 | -1.9 | 1.7 | -1.7 | 0.3 | -0.4 | 1.5 | 1.8 | 1.6 | -1.7 | 1.8 | 1.7 | -1.6 | -1.6 | 1.7 |
Delta ambulatory time before/after self-admin | 2.0 | 2.1 | 4.3 | 1.9 | -1.9 | -1.6 | 1.8 | -1.6 | 1.3 | -1.3 | 0.9 | -0.9 | 2.0 | -2.1 | -0.1 | 1.3 | 1.7 | -1.6 | 1.2 | 1.0 | -1.4 | -1.4 | 0.9 |
Indifference point AUC | 1.9 | 2.2 | 4.7 | -1.7 | 1.7 | 2.2 | -1.5 | 1.7 | -1.6 | 1.6 | -1.3 | 1.1 | -1.1 | 1.2 | -0.4 | -1.2 | -1.6 | 1.5 | -1.5 | -1.4 | 1.6 | 1.7 | -1.4 |
Stereotopy head waving bouts, day 3 | 1.9 | 2.3 | 6.6 | -1.5 | 1.5 | 0.3 | -1.6 | 1.6 | -1.5 | 1.7 | -0.9 | 0.8 | -1.9 | 1.9 | -0.5 | -2.6 | -1.5 | 1.9 | -1.3 | -1.5 | 1.7 | 1.6 | -1.1 |
Delay disc. indifference point, 8s delay | 1.9 | 2.0 | 3.8 | 1.8 | -1.8 | -0.9 | 1.9 | -1.2 | 1.3 | -1.5 | 1.4 | -1.5 | 1.4 | -1.5 | 0.5 | 1.4 | 1.8 | -1.6 | 1.3 | 1.2 | -1.2 | -1.1 | 1.1 |
Change in fecal boli incidents, locomotor task | 1.9 | 1.8 | 2.9 | 1.3 | -1.3 | -1.4 | 1.5 | -1.4 | 1.5 | -1.5 | 1.4 | -1.3 | -0.2 | 0.2 | 1.4 | 1.2 | 1.4 | -1.4 | 1.6 | 1.7 | -1.4 | -1.3 | 1.6 |
Delay discounting water rate 0 sec | 1.8 | 2.8 | 5.0 | -1.6 | 1.6 | 1.7 | -1.8 | 2.2 | -1.9 | 1.6 | -1.2 | 0.8 | -1.3 | 1.4 | -0.6 | -2.0 | -1.8 | 2.0 | -1.7 | -1.8 | 2.1 | 2.2 | -1.6 |
Condit. Reinf. inactive responses | 1.8 | 2.2 | 3.8 | -1.7 | 1.7 | 2.0 | -1.7 | 1.6 | -1.4 | 1.9 | -0.8 | 0.6 | -1.8 | 1.9 | 0.0 | -1.4 | -1.7 | 1.5 | -1.3 | -1.2 | 1.6 | 1.5 | -1.0 |
Number of responses in last shaping day | 1.8 | 1.8 | 3.2 | 1.4 | -1.4 | -1.8 | 1.5 | -1.7 | 1.4 | -1.7 | 0.8 | -0.9 | 1.0 | -1.1 | 0.4 | 1.2 | 1.4 | -1.4 | 1.3 | 1.2 | -1.5 | -1.5 | 1.1 |
Stereotopy head waving duration, day 3 | 1.8 | 2.2 | 5.7 | -1.5 | 1.5 | 0.4 | -1.6 | 1.6 | -1.5 | 1.5 | -1.0 | 0.8 | -1.6 | 1.7 | -0.6 | -2.4 | -1.5 | 1.9 | -1.4 | -1.5 | 1.6 | 1.6 | -1.1 |
Bone: marrow area | 1.7 | 3.6 | 8.7 | -1.1 | 1.1 | 1.7 | -1.1 | 1.7 | -1.9 | 2.1 | -2.5 | 2.3 | 2.2 | -2.1 | -3.0 | -1.3 | -1.1 | 1.4 | -2.1 | -2.2 | 1.7 | 1.6 | -2.5 |
Area under the delay curve | 1.7 | 1.9 | 4.8 | 1.4 | -1.4 | -0.8 | 1.8 | -1.3 | 1.2 | -1.5 | 0.6 | -0.7 | 2.1 | -2.2 | -0.1 | 1.5 | 1.7 | -1.7 | 1.0 | 1.0 | -1.3 | -1.2 | 0.7 |
Delay disc. indifference point, 24s delay | 1.7 | 1.6 | 2.8 | 1.2 | -1.2 | -0.8 | 1.6 | -1.4 | 1.4 | -1.5 | 1.1 | -0.9 | 1.0 | -1.1 | 0.7 | 1.5 | 1.7 | -1.6 | 1.3 | 1.2 | -1.3 | -1.3 | 1.2 |
Delay discounting total patch changes 12 sec | 1.6 | 2.1 | 4.2 | -1.3 | 1.3 | 1.7 | -1.3 | 1.9 | -1.6 | 1.6 | -0.7 | 0.3 | -1.7 | 1.7 | 0.0 | -1.6 | -1.3 | 1.6 | -1.3 | -1.5 | 1.8 | 2.0 | -1.1 |
Delay discounting total patch changes 6 sec | 1.6 | 2.4 | 7.8 | -1.5 | 1.5 | 1.8 | -1.6 | 1.4 | -1.3 | 1.8 | -0.2 | 0.2 | -2.8 | 2.8 | 0.8 | -1.5 | -1.6 | 1.5 | -1.0 | -1.0 | 1.6 | 1.6 | -0.7 |
Intermittent access day 1 locomotion | 1.6 | 1.6 | 2.9 | 1.1 | -1.1 | -0.6 | 0.8 | -1.4 | 1.5 | -1.4 | 1.6 | -1.2 | -0.1 | 0.0 | 1.6 | 1.6 | 0.9 | -1.4 | 1.5 | 1.7 | -1.3 | -1.4 | 1.5 |
Total zone transitions, hab. session 1 | 1.6 | 2.2 | 4.2 | 1.4 | -1.4 | -0.5 | 1.3 | -1.6 | 1.7 | -1.2 | 1.8 | -1.4 | -0.1 | -0.0 | 1.7 | 2.0 | 1.2 | -1.7 | 1.7 | 1.8 | -1.7 | -1.6 | 1.8 |
Bone: endosteal estimation | 1.6 | 3.5 | 8.8 | -1.0 | 1.0 | 1.6 | -1.1 | 1.7 | -1.9 | 2.0 | -2.4 | 2.3 | 2.2 | -2.1 | -3.0 | -1.3 | -1.1 | 1.4 | -2.1 | -2.2 | 1.6 | 1.6 | -2.4 |
Time to tail flick, test, before self-admin | 1.6 | 1.5 | 2.8 | 1.2 | -1.2 | -1.5 | 1.2 | -1.7 | 1.4 | -1.5 | 0.9 | -0.5 | 1.1 | -1.1 | 0.3 | 1.4 | 1.2 | -1.4 | 1.2 | 1.1 | -1.5 | -1.5 | 1.1 |
Delay discount exponential model param | 1.6 | 1.7 | 4.2 | -1.3 | 1.3 | 0.7 | -1.8 | 1.2 | -1.2 | 1.4 | -0.5 | 0.7 | -2.0 | 2.0 | 0.1 | -1.5 | -1.6 | 1.6 | -1.0 | -1.0 | 1.3 | 1.2 | -0.7 |
Progressive ratio test 1 breakpoint | 1.5 | 1.5 | 2.4 | 1.5 | -1.5 | -1.2 | 1.3 | -1.3 | 1.3 | -1.3 | 1.2 | -1.0 | 0.9 | -1.0 | 0.7 | 1.3 | 1.3 | -1.4 | 1.3 | 1.3 | -1.2 | -1.3 | 1.2 |
Total locomotion distance, hab. session 1 | 1.5 | 2.1 | 3.3 | 1.4 | -1.4 | -1.0 | 1.3 | -1.6 | 1.7 | -1.4 | 1.6 | -1.4 | -0.0 | -0.1 | 1.5 | 1.8 | 1.2 | -1.6 | 1.7 | 1.7 | -1.7 | -1.6 | 1.7 |
Locomotion velocity, hab. session 1 | 1.5 | 2.1 | 3.4 | 1.3 | -1.3 | -1.0 | 1.2 | -1.7 | 1.7 | -1.4 | 1.6 | -1.4 | -0.2 | 0.1 | 1.6 | 1.9 | 1.1 | -1.6 | 1.7 | 1.8 | -1.7 | -1.7 | 1.8 |
Total zone transitions, hab. session 2 | 1.5 | 2.0 | 5.6 | 1.2 | -1.2 | -0.2 | 1.1 | -1.7 | 1.6 | -1.1 | 1.3 | -0.9 | 0.7 | -0.8 | 1.1 | 2.4 | 1.2 | -1.7 | 1.5 | 1.7 | -1.8 | -1.7 | 1.4 |
Delta distance traveled before/after self-admin | 1.5 | 1.6 | 3.7 | 1.6 | -1.6 | -1.6 | 1.4 | -1.5 | 1.1 | -1.1 | 0.7 | -0.7 | 1.9 | -1.9 | -0.3 | 1.1 | 1.4 | -1.3 | 1.0 | 0.8 | -1.3 | -1.2 | 0.7 |
Delay discounting water rate 12 sec | 1.4 | 2.1 | 4.9 | 1.5 | -1.5 | -0.7 | 1.3 | -1.1 | 1.3 | -1.1 | 2.1 | -2.2 | -1.0 | 0.9 | 2.2 | 1.1 | 1.2 | -1.2 | 1.6 | 1.6 | -1.1 | -1.1 | 1.7 |
Incentive Sensitization - Breakpoint | 1.4 | 1.4 | 5.0 | -1.5 | 1.5 | 1.5 | -1.5 | 1.0 | -0.7 | 1.0 | -0.3 | 0.5 | -2.2 | 2.2 | 0.8 | -0.8 | -1.4 | 1.0 | -0.6 | -0.3 | 0.9 | 0.9 | -0.2 |
Active lever presses in extinction session 6 | 1.4 | 1.4 | 6.9 | -0.7 | 0.7 | 0.4 | -0.9 | 0.9 | -0.6 | 1.2 | 0.5 | -0.8 | -2.6 | 2.6 | 1.2 | -1.4 | -0.9 | 1.2 | -0.2 | -0.2 | 1.0 | 1.1 | 0.1 |
Locomotion in novel chamber post-restriction | 1.4 | 1.7 | 3.5 | -1.3 | 1.3 | 0.1 | -1.3 | 1.4 | -1.2 | 0.8 | -1.8 | 1.9 | 0.5 | -0.4 | -1.8 | -1.3 | -1.2 | 1.3 | -1.5 | -1.6 | 1.0 | 1.0 | -1.5 |
Fe content in liver | 1.4 | 1.7 | 4.6 | -1.0 | 1.0 | 0.3 | -1.2 | 1.6 | -1.4 | 1.3 | -0.6 | 0.5 | -1.7 | 1.8 | -0.2 | -2.2 | -1.2 | 1.7 | -1.1 | -1.2 | 1.7 | 1.6 | -0.9 |
Retroperitoneal fat weight | 1.3 | 4.3 | 7.6 | -1.9 | 1.9 | 1.7 | -1.9 | 1.9 | -2.3 | 1.9 | -2.8 | 2.6 | 1.0 | -0.8 | -2.7 | -1.7 | -2.0 | 2.0 | -2.5 | -2.5 | 1.9 | 1.9 | -2.6 |
Total sessions with >9 infusions | 1.3 | 1.4 | 2.5 | 1.5 | -1.5 | -1.6 | 1.3 | -1.0 | 1.3 | -1.3 | 1.1 | -0.9 | 0.9 | -1.0 | 0.4 | 1.0 | 1.4 | -1.3 | 1.2 | 1.0 | -1.2 | -1.1 | 1.1 |
Short access day 1 total inactive lever presses | 1.3 | 1.4 | 4.9 | 0.9 | -0.9 | -0.7 | 1.0 | -0.6 | 1.0 | -0.7 | 2.0 | -2.2 | -1.2 | 1.1 | 1.8 | 0.5 | 1.0 | -0.8 | 1.3 | 1.3 | -0.6 | -0.6 | 1.5 |
Short access day 1 locomotion | 1.3 | 1.4 | 3.5 | 1.4 | -1.4 | -1.9 | 1.3 | -1.2 | 1.3 | -1.2 | 1.2 | -0.9 | 0.6 | -0.6 | 0.5 | 0.7 | 1.4 | -1.2 | 1.3 | 1.1 | -1.1 | -1.3 | 1.2 |
Bone volume | 1.3 | 2.2 | 4.5 | -1.6 | 1.6 | 1.2 | -1.4 | 1.1 | -1.5 | 1.2 | -2.1 | 2.1 | 0.9 | -0.8 | -2.0 | -0.9 | -1.4 | 1.3 | -1.7 | -1.6 | 1.2 | 1.1 | -1.8 |
Bone: post-yield work | 1.3 | 1.8 | 2.8 | -1.1 | 1.1 | 1.4 | -1.4 | 1.7 | -1.6 | 1.5 | -1.2 | 0.9 | -0.8 | 0.9 | -0.7 | -1.5 | -1.4 | 1.5 | -1.4 | -1.5 | 1.6 | 1.7 | -1.3 |
Bone: trabecular tissue density | 1.3 | 1.8 | 3.1 | 1.1 | -1.1 | -1.0 | 1.1 | -1.6 | 1.6 | -1.6 | 1.2 | -0.8 | 0.5 | -0.6 | 1.1 | 1.7 | 1.1 | -1.6 | 1.5 | 1.6 | -1.7 | -1.6 | 1.5 |
Delay discount hyperbolic model param | 1.3 | 1.4 | 4.4 | -1.2 | 1.2 | 0.7 | -1.5 | 1.0 | -1.0 | 1.4 | -0.3 | 0.4 | -2.1 | 2.1 | 0.3 | -1.3 | -1.4 | 1.5 | -0.8 | -0.8 | 1.2 | 1.0 | -0.5 |
Fecal boli incidents, locomotor time 1 | 1.3 | 1.4 | 3.1 | 1.5 | -1.5 | -0.4 | 1.2 | -1.1 | 1.0 | -1.4 | 0.9 | -0.8 | 1.7 | -1.8 | 0.2 | 1.7 | 1.2 | -1.3 | 0.9 | 0.9 | -1.2 | -1.0 | 0.7 |
Bouts of movement, locomotor time 2 | 1.3 | 1.4 | 3.8 | -1.3 | 1.3 | 2.0 | -1.2 | 1.0 | -1.3 | 0.8 | -1.2 | 1.6 | 0.3 | -0.3 | -1.0 | -0.5 | -1.3 | 1.0 | -1.4 | -1.1 | 1.2 | 1.1 | -1.5 |
Weight adjusted by age | 1.3 | 1.5 | 2.7 | 1.3 | -1.3 | -1.0 | 1.4 | -1.2 | 1.2 | -1.4 | 1.6 | -1.7 | 0.0 | -0.1 | 1.2 | 1.1 | 1.5 | -1.2 | 1.3 | 1.2 | -1.0 | -0.9 | 1.3 |
Delay discounting total patch changes 18 sec | 1.2 | 1.6 | 3.5 | -1.4 | 1.4 | 1.9 | -1.1 | 1.5 | -1.2 | 1.3 | -0.6 | 0.4 | -1.7 | 1.7 | 0.3 | -1.0 | -1.2 | 1.2 | -1.0 | -1.1 | 1.4 | 1.6 | -0.8 |
Locomotor testing distance | 1.2 | 2.1 | 4.2 | 1.3 | -1.3 | -0.9 | 1.2 | -1.3 | 1.5 | -1.1 | 2.1 | -1.9 | -0.9 | 0.8 | 2.0 | 1.2 | 1.3 | -1.2 | 1.7 | 1.6 | -1.4 | -1.4 | 1.8 |
Intermittent access day 15 total infusions | 1.2 | 1.3 | 5.2 | 0.1 | -0.1 | 0.2 | -0.4 | -0.1 | 0.8 | -0.3 | 1.6 | -1.5 | -2.2 | 2.2 | 2.3 | 0.4 | -0.4 | -0.2 | 1.0 | 1.3 | -0.4 | -0.1 | 1.3 |
Intermittent access total locomotion | 1.2 | 1.3 | 5.7 | 0.3 | -0.3 | 0.7 | -0.2 | -0.4 | 0.9 | -0.4 | 1.9 | -1.5 | -1.8 | 1.7 | 2.4 | 1.0 | -0.1 | -0.5 | 1.1 | 1.4 | -0.6 | -0.4 | 1.4 |
Incentive Sensitization - Responses | 1.2 | 1.2 | 4.2 | -1.3 | 1.3 | 1.5 | -1.4 | 0.9 | -0.6 | 0.9 | -0.3 | 0.4 | -2.0 | 2.0 | 0.7 | -0.7 | -1.2 | 1.0 | -0.5 | -0.3 | 0.8 | 0.8 | -0.2 |
Locomotion velocity, session 7 | 1.2 | 1.3 | 2.2 | 1.2 | -1.2 | -0.9 | 1.0 | -1.1 | 1.3 | -0.9 | 1.5 | -1.2 | -0.3 | 0.3 | 1.4 | 1.1 | 1.0 | -1.2 | 1.4 | 1.4 | -1.1 | -1.1 | 1.4 |
Social responses | 1.1 | 1.4 | 2.2 | 1.5 | -1.5 | -1.1 | 1.3 | -1.2 | 1.2 | -1.3 | 1.0 | -1.1 | 0.7 | -0.7 | 0.8 | 1.3 | 1.3 | -1.3 | 1.2 | 1.2 | -1.1 | -1.3 | 1.1 |
Conditioned reinforcement - inactives | 1.1 | 1.2 | 4.0 | 0.7 | -0.7 | -0.1 | 0.7 | -0.7 | 1.1 | -0.7 | 1.8 | -1.4 | -1.3 | 1.2 | 2.0 | 0.9 | 0.8 | -0.9 | 1.3 | 1.4 | -0.8 | -0.7 | 1.5 |
Food seeking constrained by brief footshock | 1.1 | 1.4 | 2.5 | 1.1 | -1.1 | -1.6 | 1.1 | -1.1 | 1.3 | -1.2 | 1.6 | -1.4 | -0.4 | 0.4 | 1.3 | 0.8 | 1.0 | -1.0 | 1.4 | 1.2 | -1.1 | -1.2 | 1.4 |
Locomotor testing rearing | 1.0 | 1.6 | 2.4 | 1.2 | -1.2 | -0.9 | 1.3 | -1.5 | 1.4 | -1.2 | 1.4 | -1.3 | 0.5 | -0.5 | 1.1 | 1.5 | 1.3 | -1.4 | 1.4 | 1.4 | -1.4 | -1.6 | 1.3 |
Social response proportion | 1.0 | 1.1 | 2.2 | 1.5 | -1.5 | -1.2 | 1.3 | -0.9 | 0.9 | -1.1 | 1.0 | -1.1 | 0.4 | -0.4 | 0.8 | 0.8 | 1.3 | -1.0 | 1.0 | 0.9 | -0.8 | -0.9 | 1.0 |
Pavlov. Cond. lever latency | 1.0 | 1.4 | 3.7 | 1.0 | -1.0 | -1.9 | 1.0 | -1.5 | 1.5 | -1.3 | 1.0 | -0.5 | 0.1 | -0.1 | 0.7 | 0.8 | 1.0 | -1.2 | 1.4 | 1.4 | -1.5 | -1.6 | 1.4 |
Intermittent access intake escalation 2 | 1.0 | 1.0 | 4.7 | -0.9 | 0.9 | 1.0 | -1.2 | 0.8 | -0.3 | 0.7 | 0.3 | -0.4 | -2.2 | 2.2 | 1.2 | -0.6 | -1.2 | 0.7 | -0.1 | 0.1 | 0.6 | 0.7 | 0.2 |
Intermittent access terminal intake (last 3 days) | 1.0 | 1.1 | 4.3 | 0.4 | -0.4 | 0.0 | -0.1 | -0.2 | 0.9 | -0.5 | 1.6 | -1.5 | -1.7 | 1.6 | 2.1 | 0.7 | -0.1 | -0.5 | 1.1 | 1.4 | -0.6 | -0.3 | 1.4 |
Progressive ratio test 2 inactive lever presses | 1.0 | 1.2 | 5.5 | -0.0 | 0.0 | 1.1 | -0.3 | -0.0 | 0.5 | -0.1 | 1.3 | -1.3 | -2.3 | 2.2 | 2.3 | 0.5 | -0.2 | -0.1 | 0.8 | 1.1 | -0.0 | 0.0 | 1.1 |
Bone: endosteal perimeter | 1.0 | 2.1 | 4.7 | -1.2 | 1.2 | 2.2 | -1.3 | 1.5 | -1.5 | 1.9 | -1.6 | 1.6 | 0.6 | -0.6 | -1.5 | -0.8 | -1.3 | 1.2 | -1.6 | -1.5 | 1.4 | 1.5 | -1.7 |
Time to tail flick, vehicle, after self-admin | 1.0 | 1.0 | 2.6 | -0.6 | 0.6 | 0.8 | -0.4 | 0.8 | -1.1 | 0.8 | -1.4 | 1.3 | 1.2 | -1.1 | -1.6 | -0.6 | -0.3 | 0.7 | -1.2 | -1.3 | 0.9 | 0.8 | -1.4 |
Total heroin consumption | 1.0 | 1.2 | 3.7 | 0.8 | -0.8 | 0.3 | 0.8 | -1.0 | 1.0 | -0.9 | 1.8 | -1.4 | -0.7 | 0.6 | 1.9 | 1.5 | 0.8 | -1.0 | 1.2 | 1.2 | -0.9 | -0.8 | 1.3 |
Latency to leave start box in cocaine runway, M | 1.0 | 0.9 | 2.1 | -1.3 | 1.3 | 1.2 | -1.5 | 1.1 | -0.9 | 0.9 | -1.0 | 1.3 | -0.3 | 0.3 | -0.6 | -0.4 | -1.4 | 0.9 | -1.0 | -0.7 | 0.7 | 0.8 | -0.9 |
Condit. Reinf. active responses | 0.9 | 1.2 | 3.8 | -1.2 | 1.2 | 2.0 | -1.0 | 1.2 | -1.2 | 1.4 | -0.8 | 0.6 | -0.8 | 0.8 | -0.2 | -0.8 | -1.0 | 1.1 | -1.1 | -1.0 | 1.3 | 1.3 | -1.0 |
Intermittent access total infusions | 0.9 | 1.0 | 3.6 | 0.5 | -0.5 | 0.1 | 0.1 | -0.3 | 0.9 | -0.5 | 1.6 | -1.5 | -1.3 | 1.2 | 1.9 | 0.8 | 0.2 | -0.6 | 1.1 | 1.3 | -0.6 | -0.3 | 1.3 |
Progressive ratio test 1 active lever presses | 0.9 | 0.9 | 1.4 | 1.2 | -1.2 | -0.7 | 0.9 | -0.9 | 1.0 | -1.1 | 0.9 | -0.7 | 0.7 | -0.7 | 0.6 | 1.2 | 1.0 | -1.1 | 1.0 | 1.0 | -1.0 | -1.0 | 0.9 |
Bone: cortical thickness | 0.9 | 1.4 | 4.5 | 0.8 | -0.8 | -0.5 | 0.7 | -0.9 | 1.1 | -1.2 | 1.6 | -1.6 | -1.4 | 1.3 | 2.1 | 1.0 | 0.7 | -0.9 | 1.3 | 1.3 | -0.9 | -0.9 | 1.5 |
Bone: periosteal estimation | 0.9 | 1.8 | 2.9 | -1.0 | 1.0 | 1.6 | -1.1 | 1.4 | -1.5 | 1.6 | -1.6 | 1.6 | 0.8 | -0.7 | -1.6 | -1.1 | -1.1 | 1.2 | -1.6 | -1.6 | 1.4 | 1.4 | -1.7 |
Sum of active levers in priming session hrs 5-6 | 0.9 | 0.9 | 2.5 | -0.7 | 0.7 | 0.8 | -0.9 | 1.1 | -0.8 | 1.3 | 0.2 | -0.2 | -1.6 | 1.6 | 0.5 | -1.1 | -0.9 | 1.1 | -0.5 | -0.6 | 1.1 | 1.2 | -0.4 |
Seeking ratio, punishment vs. effort | 0.9 | 1.1 | 2.2 | 1.0 | -1.0 | -1.5 | 1.1 | -1.2 | 1.3 | -1.0 | 1.3 | -0.9 | 0.1 | -0.1 | 0.8 | 0.9 | 1.1 | -1.1 | 1.2 | 1.1 | -1.3 | -1.1 | 1.2 |
Indifference point 0 sec | 0.8 | 1.4 | 5.4 | 0.5 | -0.5 | -0.0 | 0.3 | -0.1 | 0.5 | -0.4 | 1.8 | -2.0 | -2.3 | 2.2 | 2.3 | 0.2 | 0.2 | -0.3 | 0.9 | 0.7 | -0.2 | 0.0 | 1.2 |
Indifference point function ln k | 0.8 | 1.1 | 1.9 | 1.0 | -1.0 | -1.1 | 0.9 | -1.0 | 1.2 | -1.4 | 1.3 | -1.2 | 0.0 | -0.1 | 1.1 | 1.1 | 0.9 | -1.1 | 1.2 | 1.1 | -1.2 | -1.1 | 1.2 |
Indifference point function log k | 0.8 | 1.1 | 1.9 | 1.0 | -1.0 | -1.1 | 0.9 | -1.0 | 1.2 | -1.4 | 1.3 | -1.2 | 0.0 | -0.1 | 1.1 | 1.1 | 0.9 | -1.1 | 1.2 | 1.1 | -1.2 | -1.1 | 1.2 |
Condit. Reinf. lever reinforcers received | 0.8 | 1.2 | 4.1 | -1.1 | 1.1 | 2.0 | -0.9 | 1.3 | -1.2 | 1.5 | -0.8 | 0.6 | -0.6 | 0.6 | -0.3 | -0.8 | -0.9 | 1.0 | -1.1 | -1.1 | 1.3 | 1.3 | -1.1 |
Post-drug Anxiety | 0.8 | 0.9 | 3.3 | -1.1 | 1.1 | 1.8 | -1.0 | 1.3 | -0.9 | 1.2 | -0.2 | 0.3 | -1.1 | 1.1 | 0.2 | -0.5 | -1.1 | 0.8 | -0.7 | -0.7 | 0.9 | 1.2 | -0.6 |
Delta time in closed arm before/after self-admin | 0.8 | 0.8 | 2.3 | 1.2 | -1.2 | -1.1 | 1.0 | -1.1 | 0.7 | -0.8 | 0.2 | -0.1 | 1.5 | -1.5 | -0.5 | 0.6 | 1.0 | -0.9 | 0.6 | 0.4 | -0.8 | -0.9 | 0.3 |
Time in open arm after self-admin | 0.8 | 0.9 | 2.2 | -0.8 | 0.8 | 1.5 | -0.7 | 1.3 | -1.0 | 1.3 | -0.0 | -0.2 | -1.2 | 1.2 | 0.3 | -1.0 | -0.6 | 1.1 | -0.7 | -0.8 | 1.2 | 1.2 | -0.6 |
Delay discounting water rate 24 sec | 0.7 | 1.0 | 1.8 | 1.3 | -1.3 | -0.2 | 1.2 | -0.9 | 0.9 | -1.0 | 1.0 | -1.1 | 0.7 | -0.7 | 0.9 | 1.2 | 1.2 | -1.1 | 1.0 | 1.0 | -0.8 | -0.9 | 0.8 |
Condit. Reinf. active-inactive response ratio | 0.7 | 0.7 | 2.7 | 1.0 | -1.0 | -0.2 | 1.1 | -0.7 | 0.5 | -0.6 | 0.2 | -0.1 | 1.6 | -1.7 | -0.3 | 1.0 | 1.1 | -0.8 | 0.4 | 0.4 | -0.6 | -0.6 | 0.2 |
Conditioned reinforcement - actives | 0.7 | 0.7 | 1.8 | 0.8 | -0.8 | -0.1 | 0.9 | -0.9 | 0.9 | -0.9 | 0.7 | -0.4 | 0.8 | -0.8 | 0.5 | 1.4 | 0.9 | -1.1 | 0.8 | 0.8 | -1.0 | -1.0 | 0.7 |
Intermittent access day 15 total locomotion | 0.7 | 0.7 | 3.5 | -0.5 | 0.5 | 1.0 | -1.1 | 0.4 | 0.1 | 0.3 | 0.8 | -0.6 | -1.9 | 1.8 | 1.5 | 0.1 | -1.0 | 0.3 | 0.3 | 0.5 | 0.2 | 0.4 | 0.5 |
Progressive ratio test 1 inactive lever presses | 0.7 | 0.7 | 1.5 | 1.0 | -1.0 | -0.7 | 0.7 | -0.6 | 0.8 | -0.6 | 1.2 | -1.1 | -0.6 | 0.5 | 1.2 | 0.4 | 0.8 | -0.7 | 1.0 | 1.0 | -0.4 | -0.6 | 1.1 |
Short access total infusions | 0.7 | 0.8 | 1.9 | 1.4 | -1.4 | -1.1 | 1.1 | -0.5 | 0.7 | -0.7 | 0.6 | -0.6 | 1.3 | -1.3 | -0.1 | 0.6 | 1.1 | -0.9 | 0.7 | 0.5 | -0.7 | -0.6 | 0.5 |
Short access total locomotion | 0.7 | 0.7 | 1.5 | 1.1 | -1.1 | -1.0 | 0.8 | -0.8 | 0.8 | -0.8 | 0.6 | -0.3 | 1.2 | -1.2 | -0.1 | 0.7 | 0.9 | -1.0 | 0.7 | 0.6 | -0.8 | -0.9 | 0.5 |
One hour access (shock baseline) | 0.7 | 0.8 | 4.5 | -0.2 | 0.2 | 0.5 | -0.6 | 0.2 | 0.3 | 0.3 | 1.0 | -0.9 | -2.1 | 2.1 | 1.7 | -0.0 | -0.5 | 0.1 | 0.5 | 0.7 | 0.1 | 0.2 | 0.8 |
Locomotion distance, session 1 | 0.7 | 0.9 | 2.7 | -1.4 | 1.4 | 1.7 | -1.5 | 0.5 | -0.7 | 1.1 | -0.8 | 1.1 | -0.8 | 0.9 | -0.1 | -0.2 | -1.5 | 0.7 | -0.8 | -0.5 | 0.5 | 0.5 | -0.6 |
Bone: maximum diameter | 0.7 | 1.2 | 3.2 | -1.0 | 1.0 | 1.8 | -0.9 | 1.2 | -1.3 | 1.4 | -1.1 | 0.9 | 0.0 | 0.0 | -0.8 | -0.8 | -0.9 | 1.1 | -1.3 | -1.3 | 1.3 | 1.3 | -1.3 |
Bone: trabecular thickness | 0.7 | 0.9 | 1.6 | -1.2 | 1.2 | 0.5 | -1.1 | 0.8 | -0.9 | 0.7 | -1.2 | 1.3 | 0.0 | 0.0 | -1.1 | -0.9 | -1.0 | 0.9 | -1.1 | -0.9 | 0.8 | 0.8 | -1.0 |
Delay disc. indifference point, 16s delay | 0.7 | 0.7 | 1.6 | 0.8 | -0.8 | -0.9 | 1.2 | -1.0 | 0.7 | -0.7 | 0.0 | -0.4 | 1.3 | -1.3 | -0.3 | 0.5 | 1.1 | -0.9 | 0.5 | 0.6 | -0.6 | -1.0 | 0.4 |
Cd content in liver | 0.7 | 0.8 | 1.9 | 0.6 | -0.6 | -1.2 | 0.5 | -0.6 | 0.8 | -0.6 | 1.3 | -1.4 | -1.1 | 1.1 | 1.2 | 0.2 | 0.5 | -0.5 | 1.0 | 0.9 | -0.6 | -0.6 | 1.1 |
Heart weight | 0.6 | 0.9 | 3.8 | -0.0 | 0.0 | -1.0 | 0.1 | -0.1 | -0.4 | -0.3 | -1.3 | 1.1 | 1.9 | -1.8 | -2.0 | -0.4 | 0.0 | 0.2 | -0.7 | -0.8 | 0.1 | -0.1 | -0.9 |
Parametrial fat weight | 0.6 | 1.1 | 4.4 | -0.1 | 0.1 | 0.4 | -0.3 | 0.5 | -0.8 | 0.5 | -1.4 | 1.3 | 2.1 | -2.0 | -2.0 | -0.2 | -0.3 | 0.4 | -1.0 | -1.0 | 0.5 | 0.4 | -1.3 |
Number of licking bursts | 0.6 | 0.8 | 2.2 | 0.8 | -0.8 | -1.5 | 0.8 | -1.1 | 1.0 | -1.2 | 0.5 | -0.4 | 0.6 | -0.7 | 0.1 | 0.8 | 0.8 | -0.9 | 0.8 | 0.9 | -1.0 | -1.0 | 0.8 |
Water consumed over 24 hours | 0.6 | 0.7 | 1.5 | 0.9 | -0.9 | -0.1 | 1.0 | -0.7 | 0.7 | -0.6 | 1.2 | -1.2 | -0.2 | 0.2 | 1.1 | 0.9 | 1.0 | -0.8 | 0.9 | 0.8 | -0.6 | -0.7 | 0.9 |
Delay discounting total patch changes 0 sec | 0.6 | 1.0 | 4.9 | 0.3 | -0.3 | 0.2 | 0.1 | 0.1 | 0.3 | -0.1 | 1.5 | -1.7 | -2.2 | 2.1 | 2.0 | 0.0 | 0.0 | -0.1 | 0.7 | 0.5 | 0.1 | 0.2 | 0.9 |
Reaction time premature initiations | 0.6 | 0.9 | 1.8 | -1.0 | 1.0 | 1.2 | -1.0 | 1.1 | -1.0 | 0.7 | -1.3 | 1.1 | 0.2 | -0.2 | -0.9 | -0.5 | -1.0 | 0.8 | -1.1 | -1.0 | 0.7 | 1.2 | -1.1 |
Intermittent access standard deviation | 0.6 | 0.6 | 3.6 | -0.4 | 0.4 | 0.1 | -0.6 | 0.5 | 0.0 | 0.6 | 0.8 | -0.8 | -1.9 | 1.9 | 1.2 | -0.6 | -0.5 | 0.4 | 0.2 | 0.3 | 0.3 | 0.5 | 0.5 |
Progressive ratio test 2 active lever presses | 0.6 | 0.6 | 2.7 | -0.1 | 0.1 | 0.3 | -0.2 | -0.3 | 0.6 | -0.2 | 0.9 | -0.7 | -1.6 | 1.6 | 1.6 | 0.4 | -0.1 | -0.3 | 0.7 | 1.0 | -0.3 | -0.3 | 1.0 |
Progressive ratio test 2 breakpoint | 0.6 | 0.6 | 3.3 | -0.2 | 0.2 | 0.3 | -0.3 | -0.1 | 0.5 | -0.2 | 0.9 | -0.7 | -1.8 | 1.8 | 1.6 | 0.2 | -0.3 | -0.1 | 0.6 | 0.8 | -0.2 | -0.1 | 0.9 |
Short access day 10 total inactive lever presses | 0.6 | 0.7 | 1.8 | -0.8 | 0.8 | 0.3 | -0.9 | 0.9 | -0.8 | 1.1 | -0.3 | 0.1 | -1.0 | 1.0 | -0.2 | -1.3 | -0.9 | 0.9 | -0.7 | -0.8 | 0.9 | 0.7 | -0.5 |
Condit. Reinf. inactive responses | 0.6 | 0.7 | 2.6 | -1.3 | 1.3 | 0.7 | -1.3 | 0.2 | -0.5 | 0.4 | -1.0 | 1.6 | -0.5 | 0.5 | -0.4 | -0.3 | -1.3 | 0.6 | -0.7 | -0.4 | 0.3 | 0.2 | -0.5 |
Bone: periosteal perimeter | 0.6 | 1.0 | 3.4 | -1.1 | 1.1 | 1.8 | -1.2 | 0.9 | -1.0 | 1.3 | -0.9 | 0.9 | -0.3 | 0.4 | -0.4 | -0.5 | -1.2 | 0.9 | -1.0 | -0.9 | 1.0 | 1.0 | -1.0 |
Distance traveled after self-admin | 0.6 | 0.7 | 3.0 | 1.1 | -1.1 | -1.2 | 0.8 | -0.8 | 0.4 | -0.5 | 0.3 | -0.1 | 1.7 | -1.7 | -0.8 | 0.4 | 0.9 | -0.6 | 0.3 | 0.0 | -0.6 | -0.5 | 0.0 |
Ambulatory time before self-admin | 0.6 | 0.6 | 1.3 | -0.8 | 0.8 | 1.1 | -0.8 | 0.8 | -0.9 | 1.0 | -0.6 | 0.6 | -0.2 | 0.2 | -0.5 | -0.7 | -0.7 | 0.9 | -0.9 | -0.8 | 0.9 | 0.9 | -0.9 |
Delay disc. indifference point, 4s delay | 0.6 | 0.7 | 3.2 | 0.6 | -0.6 | -0.3 | 0.8 | -0.5 | 0.6 | -1.0 | -0.0 | 0.1 | 1.8 | -1.8 | -0.5 | 1.1 | 0.7 | -1.0 | 0.4 | 0.3 | -0.9 | -0.5 | 0.2 |
Rest time, locomotor task time 1 | 0.6 | 0.6 | 3.9 | 0.9 | -0.9 | 0.1 | 0.4 | -0.3 | 0.4 | -0.3 | -0.0 | 0.1 | 1.9 | -2.0 | -0.6 | 1.0 | 0.5 | -0.7 | 0.2 | 0.3 | -0.6 | -0.5 | -0.0 |
Vertical activity count, locomotor time 1 | 0.6 | 0.6 | 2.1 | -0.7 | 0.7 | 0.2 | -0.5 | 0.7 | -0.8 | 0.8 | -0.3 | -0.1 | -1.4 | 1.5 | 0.2 | -1.3 | -0.5 | 0.9 | -0.6 | -0.7 | 0.9 | 0.9 | -0.4 |
Vertical activity count, locomotor time 2 | 0.6 | 0.7 | 1.9 | -0.3 | 0.3 | -0.3 | -0.6 | 0.9 | -0.9 | 0.6 | -0.7 | 0.6 | 0.6 | -0.6 | -1.4 | -1.2 | -0.7 | 0.8 | -0.9 | -1.1 | 0.8 | 0.8 | -1.0 |
Mn content in liver | 0.6 | 0.6 | 1.7 | -0.7 | 0.7 | 0.8 | -0.4 | 0.4 | -0.6 | 0.5 | -1.2 | 1.3 | 1.1 | -1.1 | -1.3 | -0.0 | -0.4 | 0.4 | -0.8 | -0.7 | 0.3 | 0.4 | -1.0 |
Mean num. licks in bursts | 0.5 | 0.7 | 3.9 | -0.2 | 0.2 | 0.6 | -0.1 | 0.0 | 0.2 | 0.1 | 0.9 | -0.9 | -2.0 | 1.9 | 1.6 | 0.1 | -0.1 | 0.1 | 0.4 | 0.4 | -0.0 | 0.0 | 0.7 |
Reaction time mean minus median AUC | 0.5 | 0.7 | 2.3 | -0.9 | 0.9 | 1.1 | -0.8 | 0.6 | -0.7 | 0.7 | -0.3 | 0.4 | -1.5 | 1.5 | 0.5 | -0.6 | -0.8 | 0.8 | -0.6 | -0.3 | 0.7 | 0.7 | -0.3 |
Reaction time premature initiation rate | 0.5 | 0.7 | 1.6 | -0.5 | 0.5 | 0.6 | -0.5 | 0.7 | -0.8 | 0.5 | -1.3 | 1.1 | 1.0 | -0.9 | -1.3 | -0.4 | -0.4 | 0.5 | -0.9 | -0.9 | 0.5 | 0.8 | -1.1 |
Conditioned locomotion | 0.5 | 0.6 | 1.1 | 0.8 | -0.8 | -0.6 | 0.7 | -0.7 | 0.8 | -0.8 | 1.0 | -1.0 | -0.3 | 0.3 | 1.0 | 0.6 | 0.8 | -0.6 | 0.9 | 0.8 | -0.7 | -0.6 | 0.9 |
Saline control response | 0.5 | 0.7 | 1.6 | -0.9 | 0.9 | 1.3 | -0.7 | 0.9 | -0.9 | 1.0 | -0.7 | 0.7 | -0.6 | 0.6 | -0.3 | -0.7 | -0.7 | 0.9 | -0.9 | -0.9 | 0.9 | 0.9 | -0.8 |
Time in novel zone, hab. session 1 | 0.5 | 0.5 | 1.6 | -0.2 | 0.2 | -0.6 | -0.2 | 0.7 | -0.6 | 0.6 | -0.7 | 0.4 | 0.5 | -0.4 | -1.2 | -1.3 | -0.3 | 0.7 | -0.7 | -0.8 | 0.7 | 0.7 | -0.8 |
Locomotion velocity, NPP test | 0.5 | 0.7 | 1.5 | 0.3 | -0.3 | -0.6 | 0.3 | -1.2 | 1.1 | -0.9 | 0.6 | -0.3 | 0.1 | -0.2 | 0.6 | 1.2 | 0.4 | -0.9 | 0.9 | 1.1 | -1.2 | -1.2 | 0.9 |
Extinction: sum of active levers before priming | 0.5 | 0.5 | 2.2 | -0.4 | 0.4 | 1.5 | -0.7 | 0.9 | -0.7 | 1.0 | 0.1 | -0.0 | -0.7 | 0.7 | 0.3 | -0.4 | -0.7 | 0.7 | -0.5 | -0.5 | 0.9 | 1.0 | -0.5 |
Delay disc. indifference point, 2s delay | 0.5 | 0.6 | 3.3 | 0.5 | -0.5 | -0.3 | 0.8 | -0.5 | 0.4 | -0.8 | -0.3 | 0.3 | 1.8 | -1.8 | -0.8 | 0.8 | 0.6 | -0.8 | 0.2 | 0.2 | -0.7 | -0.5 | -0.0 |
Distance moved, locomotor task time 2 | 0.5 | 0.6 | 2.0 | -0.6 | 0.6 | -0.9 | -0.6 | 0.5 | -0.6 | 0.4 | -0.9 | 0.9 | 0.4 | -0.3 | -1.4 | -1.2 | -0.5 | 0.8 | -0.8 | -0.9 | 0.5 | 0.5 | -0.8 |
Latency to leave start box in cocaine runway, F | 0.5 | 0.6 | 2.2 | 0.4 | -0.4 | -1.5 | 0.4 | -1.0 | 0.9 | -1.0 | -0.1 | 0.2 | 0.8 | -0.8 | -0.3 | 0.8 | 0.3 | -0.8 | 0.6 | 0.5 | -1.2 | -0.9 | 0.5 |
Mg content in liver | 0.5 | 0.5 | 1.4 | -0.5 | 0.5 | -0.0 | -0.2 | 0.9 | -0.9 | 0.7 | -0.7 | 0.4 | 0.4 | -0.3 | -1.1 | -1.2 | -0.2 | 0.8 | -0.8 | -1.1 | 0.9 | 0.9 | -0.9 |
Soleus weight | 0.4 | 1.2 | 2.4 | -0.5 | 0.5 | 1.6 | -0.5 | 1.3 | -1.3 | 1.3 | -1.1 | 0.8 | 0.8 | -0.8 | -1.2 | -0.8 | -0.5 | 0.9 | -1.2 | -1.3 | 1.3 | 1.3 | -1.4 |
Delay discounting total patch changes 24 sec | 0.4 | 0.5 | 2.3 | -0.4 | 0.4 | 1.5 | -0.5 | 0.9 | -0.8 | 0.7 | -0.2 | -0.1 | -0.4 | 0.4 | 0.1 | -0.4 | -0.6 | 0.6 | -0.7 | -0.7 | 0.9 | 1.1 | -0.7 |
Reaction time trials AUC | 0.4 | 0.5 | 1.0 | -0.9 | 0.9 | 1.0 | -1.0 | 0.8 | -0.7 | 0.5 | -0.7 | 0.6 | -0.6 | 0.6 | -0.2 | -0.4 | -1.0 | 0.6 | -0.7 | -0.5 | 0.5 | 0.8 | -0.6 |
Pavlov. Cond. change in total contacts | 0.4 | 0.6 | 1.5 | -0.6 | 0.6 | 1.2 | -0.6 | 0.9 | -0.9 | 0.6 | -0.9 | 0.7 | 0.6 | -0.6 | -0.8 | -0.2 | -0.6 | 0.7 | -0.9 | -0.9 | 0.7 | 0.9 | -1.0 |
Pavlov. Cond. lever contacts | 0.4 | 0.6 | 1.7 | -0.5 | 0.5 | 1.3 | -0.6 | 1.0 | -1.0 | 0.8 | -0.7 | 0.2 | 0.2 | -0.2 | -0.6 | -0.4 | -0.6 | 0.7 | -0.9 | -0.9 | 0.9 | 1.0 | -1.0 |
Pavlov. Cond. response bias | 0.4 | 0.5 | 1.8 | -0.5 | 0.5 | 1.3 | -0.6 | 0.9 | -0.9 | 0.7 | -0.6 | 0.2 | 0.0 | -0.0 | -0.4 | -0.3 | -0.6 | 0.6 | -0.8 | -0.8 | 0.8 | 0.9 | -0.8 |
Intermittent access intake day 1-15 change | 0.4 | 0.4 | 2.1 | -0.3 | 0.3 | -0.0 | -0.6 | 0.0 | 0.2 | -0.3 | 0.5 | -0.5 | -1.4 | 1.4 | 1.1 | -0.1 | -0.6 | 0.1 | 0.3 | 0.5 | -0.0 | 0.1 | 0.5 |
Intermittent access intake escalation | 0.4 | 0.4 | 2.3 | -0.3 | 0.3 | 0.0 | -0.6 | 0.2 | 0.1 | -0.1 | 0.6 | -0.7 | -1.5 | 1.5 | 1.1 | -0.2 | -0.6 | 0.2 | 0.3 | 0.4 | 0.0 | 0.2 | 0.5 |
Lifetime Intake | 0.4 | 0.5 | 1.3 | 0.6 | -0.6 | -0.2 | 0.2 | -0.2 | 0.7 | -0.4 | 1.1 | -1.0 | -0.5 | 0.5 | 1.1 | 0.7 | 0.3 | -0.6 | 0.8 | 0.9 | -0.6 | -0.3 | 0.9 |
One hour access (0.3 mA shock) | 0.4 | 0.5 | 2.0 | 0.2 | -0.2 | 0.9 | -0.3 | -0.1 | 0.4 | 0.1 | 1.0 | -0.9 | -1.0 | 1.0 | 1.4 | 0.6 | -0.3 | -0.3 | 0.6 | 0.8 | -0.2 | -0.1 | 0.7 |
Condit. Reinf. lever presses | 0.4 | 0.5 | 1.2 | 0.9 | -0.9 | -0.3 | 0.8 | -0.6 | 0.7 | -0.6 | 1.0 | -1.1 | 0.0 | -0.1 | 0.8 | 0.7 | 0.8 | -0.7 | 0.8 | 0.7 | -0.5 | -0.6 | 0.7 |
Total locomotion distance, NPP test | 0.4 | 0.5 | 1.2 | 0.3 | -0.3 | -0.5 | 0.3 | -1.0 | 0.9 | -0.7 | 0.5 | -0.2 | 0.3 | -0.3 | 0.4 | 1.1 | 0.4 | -0.8 | 0.7 | 0.9 | -1.0 | -1.0 | 0.8 |
Pavlov. Cond. magazine entry latency | 0.4 | 0.5 | 0.9 | 0.7 | -0.7 | -1.0 | 0.6 | -0.9 | 0.8 | -0.9 | 0.7 | -0.6 | 0.1 | -0.2 | 0.5 | 0.7 | 0.6 | -0.7 | 0.8 | 0.8 | -0.9 | -0.9 | 0.8 |
Bone: cortical porosity | 0.4 | 0.4 | 0.8 | 0.4 | -0.4 | -0.7 | 0.7 | -0.9 | 0.8 | -0.9 | 0.4 | -0.1 | 0.1 | -0.2 | 0.5 | 0.7 | 0.7 | -0.8 | 0.7 | 0.8 | -0.8 | -0.9 | 0.8 |
Bone: cortical thickness | 0.4 | 0.5 | 1.1 | 0.7 | -0.7 | -0.8 | 0.7 | -0.9 | 0.8 | -1.0 | 0.6 | -0.5 | 0.1 | -0.1 | 0.6 | 0.8 | 0.7 | -0.7 | 0.8 | 0.7 | -0.8 | -0.8 | 0.8 |
Bone: maximum force | 0.4 | 0.6 | 1.2 | -0.5 | 0.5 | 0.7 | -0.6 | 1.1 | -1.0 | 1.0 | -0.7 | 0.5 | -0.2 | 0.2 | -0.6 | -1.0 | -0.6 | 0.9 | -0.9 | -1.0 | 1.0 | 1.0 | -0.9 |
Bone: tissue strength | 0.4 | 0.4 | 0.7 | 0.8 | -0.8 | -0.7 | 0.6 | -0.3 | 0.6 | -0.6 | 0.7 | -0.8 | -0.1 | 0.0 | 0.6 | 0.4 | 0.6 | -0.6 | 0.7 | 0.7 | -0.5 | -0.5 | 0.7 |
Delay disc. indifference point, 0s delay | 0.4 | 0.4 | 2.5 | 0.3 | -0.3 | -0.1 | 0.4 | -0.5 | 0.3 | -0.8 | -0.4 | 0.3 | 1.6 | -1.6 | -0.7 | 0.9 | 0.3 | -0.6 | 0.1 | 0.2 | -0.6 | -0.3 | -0.1 |
Time >=10cm from walls, locomotor time 1 | 0.4 | 0.4 | 1.6 | 0.4 | -0.4 | -0.2 | 0.2 | -0.2 | 0.2 | -0.2 | 1.3 | -1.1 | -1.0 | 1.0 | 1.1 | -0.1 | -0.0 | -0.1 | 0.5 | 0.3 | 0.1 | -0.2 | 0.5 |
Time >=10cm from walls, locomotor time 2 | 0.4 | 0.4 | 0.9 | -0.5 | 0.5 | -0.2 | -0.3 | 0.5 | -0.7 | 0.5 | -0.5 | 0.7 | 0.2 | -0.2 | -0.9 | -0.9 | -0.5 | 0.6 | -0.7 | -0.9 | 0.7 | 0.5 | -0.8 |
Run reversals in cocaine runway, females | 0.4 | 0.4 | 0.9 | 0.5 | -0.5 | -0.4 | 0.6 | -0.6 | 0.7 | -1.0 | 0.6 | -0.5 | 0.2 | -0.2 | 0.6 | 0.9 | 0.6 | -0.8 | 0.7 | 0.8 | -0.8 | -0.5 | 0.7 |
Run reversals in cocaine runway, males | 0.4 | 0.4 | 1.3 | -0.9 | 0.9 | 1.1 | -0.8 | 0.3 | -0.3 | 0.5 | -0.3 | 0.2 | -1.1 | 1.1 | 0.6 | 0.1 | -0.8 | 0.4 | -0.3 | 0.1 | 0.3 | 0.3 | -0.1 |
Rb content in liver | 0.4 | 0.5 | 1.4 | 0.5 | -0.5 | -1.1 | 0.4 | -0.9 | 0.7 | -1.2 | 0.5 | -0.5 | 0.3 | -0.3 | 0.3 | 0.6 | 0.4 | -0.7 | 0.7 | 0.9 | -0.8 | -0.9 | 0.6 |
Se content in liver | 0.4 | 0.4 | 2.6 | -0.5 | 0.5 | -0.5 | -0.4 | 0.5 | -0.2 | 0.3 | 0.2 | -0.2 | -1.6 | 1.6 | 0.6 | -1.0 | -0.4 | 0.6 | -0.1 | -0.2 | 0.5 | 0.5 | 0.1 |
Tail length | 0.3 | 0.9 | 2.8 | 0.7 | -0.7 | -0.5 | 0.7 | -0.7 | 0.8 | -0.9 | 1.3 | -1.4 | -1.1 | 1.0 | 1.7 | 0.6 | 0.8 | -0.7 | 1.0 | 1.3 | -0.6 | -0.6 | 1.2 |
Std. dev. time between licks in bursts | 0.3 | 0.4 | 2.0 | 0.1 | -0.1 | 0.2 | 0.2 | -0.0 | 0.2 | 0.0 | 0.8 | -0.9 | -1.4 | 1.4 | 1.3 | 0.1 | 0.2 | -0.0 | 0.4 | 0.5 | -0.1 | -0.0 | 0.6 |
Cocaine response after cond. corrected | 0.3 | 0.3 | 1.7 | -0.6 | 0.6 | 0.9 | -0.6 | 0.2 | -0.1 | 0.3 | 0.2 | 0.1 | -1.3 | 1.3 | 0.9 | 0.1 | -0.6 | 0.2 | -0.0 | -0.0 | 0.1 | 0.2 | 0.2 |
Cocaine response after cond. not corrected | 0.3 | 0.4 | 1.6 | -0.4 | 0.4 | 0.8 | -0.3 | -0.3 | 0.3 | 0.1 | 0.6 | -0.2 | -1.3 | 1.2 | 1.2 | 0.6 | -0.3 | -0.2 | 0.3 | 0.4 | -0.3 | -0.3 | 0.6 |
Condit. Reinf. lever presses | 0.3 | 0.5 | 1.2 | -0.3 | 0.3 | 1.1 | -0.3 | 1.0 | -0.9 | 0.9 | -0.3 | -0.2 | -0.1 | 0.1 | -0.3 | -0.6 | -0.4 | 0.7 | -0.7 | -0.8 | 1.0 | 1.1 | -0.8 |
Pavlov. Cond. index score | 0.3 | 0.4 | 1.7 | -0.3 | 0.3 | 1.3 | -0.4 | 0.9 | -0.8 | 0.7 | -0.1 | -0.3 | -0.6 | 0.6 | 0.3 | -0.3 | -0.4 | 0.6 | -0.5 | -0.6 | 0.9 | 1.0 | -0.5 |
Pavlov. Cond. intertrial magazine entries | 0.3 | 0.5 | 0.7 | -0.8 | 0.8 | 0.7 | -0.6 | 0.7 | -0.7 | 0.9 | -0.5 | 0.6 | -0.7 | 0.7 | -0.1 | -0.8 | -0.6 | 0.7 | -0.6 | -0.7 | 0.8 | 0.8 | -0.5 |
Intermitt. access day 15 inactive lever presses | 0.3 | 0.4 | 1.7 | 0.2 | -0.2 | 0.6 | -0.0 | -0.0 | 0.3 | -0.3 | 1.1 | -1.0 | -1.0 | 0.9 | 1.3 | 0.4 | 0.0 | -0.2 | 0.5 | 0.7 | -0.1 | -0.1 | 0.6 |
Intermittent access day 1 total infusions | 0.3 | 0.4 | 1.0 | 0.4 | -0.4 | 0.2 | 0.2 | -0.5 | 0.7 | -0.6 | 0.8 | -0.5 | -0.2 | 0.1 | 1.0 | 1.0 | 0.3 | -0.7 | 0.7 | 0.9 | -0.6 | -0.5 | 0.8 |
Short access day 10 total infusions | 0.3 | 0.3 | 1.5 | 0.8 | -0.8 | -1.2 | 0.5 | -0.1 | 0.4 | -0.5 | 0.3 | -0.2 | 1.0 | -1.0 | -0.4 | 0.2 | 0.5 | -0.5 | 0.4 | 0.2 | -0.4 | -0.3 | 0.2 |
Compulsive drug intake | 0.3 | 0.3 | 1.5 | -0.1 | 0.1 | 1.2 | -0.1 | 0.4 | -0.6 | 0.4 | -0.5 | 0.4 | 1.0 | -1.0 | -0.7 | 0.2 | -0.1 | 0.2 | -0.6 | -0.6 | 0.4 | 0.4 | -0.8 |
Locomotion velocity, session 1 | 0.3 | 0.3 | 0.9 | -0.7 | 0.7 | 0.4 | -0.9 | 0.2 | -0.3 | 0.5 | -0.4 | 0.6 | -0.7 | 0.7 | -0.0 | -0.4 | -1.0 | 0.5 | -0.4 | -0.2 | 0.3 | 0.2 | -0.2 |
Locomotion velocity, session 2 | 0.3 | 0.4 | 1.1 | -0.7 | 0.7 | 1.1 | -1.0 | 0.3 | -0.4 | 0.7 | -0.2 | 0.4 | -0.8 | 0.8 | 0.2 | -0.2 | -1.0 | 0.5 | -0.4 | -0.2 | 0.4 | 0.3 | -0.3 |
Locomotion distance, session 3 | 0.3 | 0.3 | 0.9 | -0.3 | 0.3 | 0.5 | -0.3 | 0.5 | -0.5 | 1.0 | -0.7 | 0.8 | 0.5 | -0.4 | -0.8 | -0.5 | -0.4 | 0.4 | -0.6 | -0.5 | 0.4 | 0.5 | -0.6 |
Condit. Reinf. active-inactive response ratio | 0.3 | 0.3 | 1.5 | 0.6 | -0.6 | -0.2 | 0.6 | -0.2 | 0.3 | -0.1 | 0.9 | -1.2 | -0.5 | 0.5 | 0.8 | 0.1 | 0.5 | -0.3 | 0.5 | 0.5 | -0.1 | -0.2 | 0.5 |
Time in familiar zone, hab. session 2 | 0.3 | 0.3 | 1.8 | 0.2 | -0.2 | 0.6 | 0.3 | -0.1 | -0.0 | 0.1 | -0.4 | 0.4 | 1.3 | -1.3 | -0.6 | 0.5 | 0.3 | -0.3 | -0.1 | -0.2 | -0.1 | -0.1 | -0.3 |
Pavlov. Cond. lever latency | 0.3 | 0.3 | 0.6 | 0.8 | -0.8 | -0.6 | 0.8 | -0.5 | 0.5 | -0.4 | 0.5 | -0.5 | 0.6 | -0.7 | 0.1 | 0.4 | 0.8 | -0.6 | 0.5 | 0.5 | -0.5 | -0.5 | 0.4 |
Bone: connectivity density | 0.3 | 0.5 | 1.6 | -0.9 | 0.9 | 0.4 | -0.8 | 0.1 | -0.5 | 0.5 | -1.2 | 1.3 | 0.6 | -0.6 | -1.2 | -0.3 | -0.7 | 0.5 | -0.8 | -0.5 | 0.3 | 0.2 | -0.8 |
Bone: cortical tissue density | 0.3 | 0.4 | 1.6 | -0.8 | 0.8 | -0.1 | -1.0 | 0.0 | -0.2 | -0.3 | -1.0 | 1.3 | 0.2 | -0.2 | -0.7 | 0.1 | -1.0 | 0.3 | -0.5 | -0.2 | -0.1 | 0.0 | -0.4 |
Bone: elastic displacement | 0.3 | 0.3 | 1.0 | 0.5 | -0.5 | -1.0 | 0.6 | -0.6 | 0.6 | -0.7 | 0.6 | -0.5 | -0.0 | 0.0 | 0.4 | 0.2 | 0.6 | -0.5 | 0.6 | 0.6 | -0.6 | -0.5 | 0.6 |
Bone: final moment | 0.3 | 0.4 | 1.0 | -0.2 | 0.2 | 0.9 | -0.3 | 1.0 | -0.9 | 1.0 | -0.4 | 0.1 | -0.1 | 0.1 | -0.3 | -0.8 | -0.3 | 0.7 | -0.7 | -0.8 | 1.0 | 0.9 | -0.7 |
Bone: maximum moment | 0.3 | 0.6 | 1.1 | -0.5 | 0.5 | 0.8 | -0.6 | 1.0 | -0.9 | 0.9 | -0.7 | 0.6 | -0.2 | 0.2 | -0.6 | -0.9 | -0.6 | 0.8 | -0.8 | -0.9 | 1.0 | 1.0 | -0.9 |
Delta time in open arm before/after self-admin | 0.3 | 0.3 | 0.5 | -0.2 | 0.2 | 0.4 | -0.2 | 0.7 | -0.6 | 0.7 | -0.4 | 0.0 | 0.3 | -0.3 | -0.6 | -0.6 | -0.1 | 0.5 | -0.6 | -0.7 | 0.7 | 0.7 | -0.6 |
Total resting periods, locomotor time 2 | 0.3 | 0.4 | 2.1 | -0.6 | 0.6 | 1.5 | -0.6 | 0.4 | -0.7 | 0.2 | -0.5 | 0.8 | 0.2 | -0.2 | -0.3 | 0.1 | -0.7 | 0.4 | -0.7 | -0.4 | 0.6 | 0.5 | -0.7 |
Rest time, locomotor task time 2 | 0.3 | 0.4 | 1.2 | 0.7 | -0.7 | 0.5 | 0.4 | -0.3 | 0.6 | -0.3 | 0.8 | -0.7 | -0.3 | 0.2 | 1.1 | 1.1 | 0.3 | -0.6 | 0.7 | 0.6 | -0.6 | -0.5 | 0.7 |
Seeking ratio, delayed vs. immediate footshock | 0.3 | 0.4 | 1.6 | -0.3 | 0.3 | -1.3 | -0.1 | -0.4 | 0.5 | -0.9 | -0.6 | 1.2 | 0.6 | -0.6 | -0.7 | 0.4 | 0.0 | -0.3 | 0.1 | 0.2 | -0.8 | -0.7 | 0.1 |
K content in liver | 0.3 | 0.3 | 1.1 | 0.0 | -0.0 | -0.2 | 0.4 | 0.4 | -0.5 | 0.4 | -0.5 | 0.1 | 1.0 | -0.9 | -1.0 | -0.6 | 0.4 | 0.3 | -0.5 | -0.7 | 0.5 | 0.4 | -0.7 |
Zn content in liver | 0.3 | 0.3 | 1.4 | 0.4 | -0.4 | 0.1 | 0.4 | 0.2 | 0.2 | 0.1 | 1.0 | -1.2 | -1.0 | 0.9 | 1.1 | -0.1 | 0.4 | -0.1 | 0.4 | 0.4 | 0.1 | 0.2 | 0.5 |
BMI with tail | 0.2 | 0.6 | 3.5 | 0.6 | -0.6 | 0.2 | 0.7 | -0.0 | -0.2 | 0.2 | -0.6 | 0.4 | 1.9 | -1.9 | -1.2 | 0.3 | 0.6 | -0.2 | -0.3 | -0.4 | -0.0 | -0.0 | -0.6 |
Liver weight, right | 0.2 | 0.3 | 0.6 | 0.4 | -0.4 | -0.5 | 0.5 | -0.6 | 0.6 | -0.5 | 0.3 | -0.1 | 0.4 | -0.4 | 0.1 | 0.6 | 0.5 | -0.6 | 0.5 | 0.5 | -0.8 | -0.7 | 0.5 |
Intraocular pressure | 0.2 | 0.2 | 0.9 | -0.3 | 0.3 | -0.7 | -0.2 | 0.1 | -0.2 | -0.1 | -0.9 | 0.9 | 0.5 | -0.5 | -1.0 | -0.7 | -0.2 | 0.2 | -0.4 | -0.3 | 0.2 | 0.1 | -0.4 |
Food consumed during 24 hour testing period | 0.2 | 0.3 | 1.1 | -0.0 | 0.0 | -0.1 | 0.1 | -0.4 | 0.4 | -0.5 | 0.6 | -0.4 | -1.0 | 1.0 | 1.0 | 0.5 | 0.1 | -0.2 | 0.5 | 0.6 | -0.5 | -0.4 | 0.7 |
Delay discounting time to switch 0 sec | 0.2 | 0.3 | 0.9 | 0.2 | -0.2 | -0.7 | 0.3 | -0.8 | 0.5 | -0.3 | -0.3 | 0.6 | 1.0 | -1.0 | -0.7 | 0.4 | 0.3 | -0.5 | 0.2 | 0.2 | -0.6 | -0.7 | 0.1 |
Delay discounting water rate 18 sec | 0.2 | 0.2 | 1.0 | 0.4 | -0.4 | -0.2 | -0.0 | 0.3 | -0.4 | 0.1 | -0.3 | -0.1 | 1.0 | -1.0 | -0.8 | -0.4 | -0.0 | 0.2 | -0.4 | -0.4 | 0.5 | 0.2 | -0.6 |
Delay discounting water rate 6 sec | 0.2 | 0.2 | 0.5 | 0.6 | -0.6 | 0.1 | 0.7 | -0.3 | 0.3 | -0.4 | 0.6 | -0.7 | 0.1 | -0.1 | 0.6 | 0.4 | 0.6 | -0.5 | 0.5 | 0.5 | -0.2 | -0.3 | 0.4 |
Reaction time number correct | 0.2 | 0.3 | 0.7 | -0.8 | 0.8 | 0.9 | -0.8 | 0.6 | -0.4 | 0.3 | -0.5 | 0.4 | -0.7 | 0.7 | 0.1 | -0.2 | -0.9 | 0.5 | -0.5 | -0.3 | 0.3 | 0.5 | -0.3 |
Reaction time mean minus median | 0.2 | 0.2 | 1.3 | -0.2 | 0.2 | 0.2 | -0.1 | -0.1 | 0.1 | -0.0 | 0.3 | -0.2 | -1.1 | 1.1 | 0.8 | 0.0 | -0.1 | 0.0 | 0.2 | 0.4 | -0.1 | -0.1 | 0.4 |
Reaction time trials correct on left | 0.2 | 0.3 | 0.7 | -0.8 | 0.8 | 0.9 | -0.8 | 0.6 | -0.4 | 0.3 | -0.5 | 0.4 | -0.7 | 0.7 | 0.1 | -0.2 | -0.9 | 0.5 | -0.5 | -0.3 | 0.3 | 0.5 | -0.3 |
Reaction time trials on left | 0.2 | 0.3 | 0.8 | -0.8 | 0.8 | 0.9 | -0.8 | 0.6 | -0.5 | 0.3 | -0.5 | 0.4 | -0.7 | 0.7 | 0.1 | -0.2 | -0.8 | 0.5 | -0.5 | -0.3 | 0.4 | 0.6 | -0.4 |
Median of all reaction times | 0.2 | 0.3 | 1.3 | 0.3 | -0.3 | -0.8 | 0.3 | -0.0 | -0.3 | 0.3 | -0.6 | 0.7 | 1.0 | -0.9 | -1.1 | -0.8 | 0.3 | 0.2 | -0.4 | -0.5 | 0.2 | 0.0 | -0.5 |
Std. dev. reaction times | 0.2 | 0.2 | 0.9 | 0.2 | -0.2 | -0.3 | 0.2 | -0.3 | 0.4 | -0.1 | 0.5 | -0.2 | -0.9 | 0.9 | 0.8 | 0.0 | 0.2 | -0.2 | 0.4 | 0.5 | -0.3 | -0.4 | 0.6 |
Reaction time trials completed | 0.2 | 0.3 | 0.8 | -0.8 | 0.8 | 0.9 | -0.8 | 0.6 | -0.5 | 0.3 | -0.5 | 0.4 | -0.7 | 0.7 | 0.1 | -0.2 | -0.8 | 0.5 | -0.5 | -0.3 | 0.4 | 0.6 | -0.4 |
Condit. Reinf. active minus inactive responses | 0.2 | 0.2 | 1.5 | -0.2 | 0.2 | 1.2 | -0.1 | 0.3 | -0.4 | 0.3 | -0.5 | 0.4 | 0.5 | -0.5 | -0.3 | 0.3 | -0.1 | 0.1 | -0.4 | -0.3 | 0.3 | 0.3 | -0.5 |
Pavlov. Cond. lever-magazine prob. diff. | 0.2 | 0.3 | 1.5 | -0.2 | 0.2 | 1.2 | -0.3 | 0.8 | -0.6 | 0.6 | 0.0 | -0.4 | -0.5 | 0.5 | 0.3 | -0.1 | -0.3 | 0.4 | -0.4 | -0.5 | 0.7 | 0.8 | -0.4 |
Cocaine induced anxiety | 0.2 | 0.2 | 0.7 | -0.4 | 0.4 | 0.7 | -0.3 | 0.6 | -0.2 | 0.4 | -0.0 | -0.2 | -0.8 | 0.8 | 0.5 | -0.1 | -0.5 | 0.3 | -0.1 | -0.1 | 0.3 | 0.6 | -0.0 |
Short access day 1 total infusions | 0.2 | 0.3 | 1.1 | 0.6 | -0.6 | -1.0 | 0.6 | -0.3 | 0.5 | -0.6 | 0.4 | -0.3 | 0.4 | -0.4 | 0.0 | 0.2 | 0.6 | -0.5 | 0.5 | 0.3 | -0.4 | -0.5 | 0.4 |
Short access day 10 total locomotion | 0.2 | 0.2 | 0.4 | 0.5 | -0.5 | -0.4 | 0.2 | -0.5 | 0.5 | -0.6 | 0.4 | -0.1 | 0.6 | -0.6 | 0.1 | 0.6 | 0.3 | -0.6 | 0.4 | 0.4 | -0.5 | -0.6 | 0.3 |
Context. condit. distance diff. score | 0.2 | 0.3 | 0.7 | 0.7 | -0.7 | 0.6 | 0.6 | -0.1 | 0.3 | -0.1 | 0.8 | -0.8 | 0.1 | -0.1 | 0.8 | 0.9 | 0.5 | -0.6 | 0.5 | 0.4 | -0.2 | -0.1 | 0.4 |
Locomotion distance, session 8 | 0.2 | 0.3 | 1.6 | 0.3 | -0.3 | 0.9 | 0.1 | -0.5 | 0.5 | -0.1 | 0.5 | -0.1 | 0.1 | -0.2 | 0.7 | 1.3 | 0.1 | -0.6 | 0.4 | 0.6 | -0.5 | -0.5 | 0.4 |
Incentive salience index mean | 0.2 | 0.2 | 0.5 | 0.6 | -0.6 | -0.2 | 0.5 | -0.4 | 0.4 | -0.3 | 0.6 | -0.7 | 0.2 | -0.2 | 0.4 | 0.3 | 0.5 | -0.5 | 0.5 | 0.5 | -0.3 | -0.4 | 0.4 |
Novelty place preference | 0.2 | 0.2 | 0.7 | -0.4 | 0.4 | -0.8 | -0.3 | -0.2 | 0.0 | -0.0 | -0.6 | 0.8 | 0.5 | -0.4 | -0.8 | -0.4 | -0.4 | 0.2 | -0.2 | -0.1 | -0.1 | -0.2 | -0.2 |
Time in novel zone, NPP test | 0.2 | 0.2 | 1.0 | -0.4 | 0.4 | -0.6 | -0.4 | -0.1 | -0.1 | 0.1 | -0.7 | 0.9 | 0.6 | -0.6 | -1.0 | -0.4 | -0.4 | 0.2 | -0.3 | -0.2 | -0.0 | -0.1 | -0.4 |
Pavlov. Cond. lever contacts | 0.2 | 0.2 | 0.9 | -0.5 | 0.5 | 0.7 | -0.5 | 0.2 | -0.2 | 0.2 | 0.1 | -0.2 | -1.0 | 1.0 | 0.6 | -0.0 | -0.5 | 0.3 | -0.1 | -0.0 | 0.2 | 0.2 | 0.0 |
Bone: cortical apparent density | 0.2 | 0.3 | 1.4 | -0.8 | 0.8 | -0.1 | -0.9 | -0.0 | -0.1 | -0.3 | -0.9 | 1.2 | 0.2 | -0.1 | -0.6 | 0.2 | -1.0 | 0.2 | -0.4 | -0.1 | -0.2 | -0.0 | -0.3 |
Bone: cortical porosity | 0.2 | 0.2 | 0.6 | 0.1 | -0.1 | -0.6 | 0.4 | -0.7 | 0.6 | -0.7 | 0.3 | 0.0 | -0.2 | 0.2 | 0.5 | 0.4 | 0.4 | -0.5 | 0.6 | 0.6 | -0.6 | -0.7 | 0.6 |
Bone: final force | 0.2 | 0.4 | 0.9 | -0.1 | 0.1 | 0.8 | -0.1 | 0.9 | -0.8 | 1.0 | -0.3 | -0.0 | 0.1 | -0.1 | -0.4 | -0.7 | -0.1 | 0.6 | -0.6 | -0.8 | 0.9 | 0.9 | -0.7 |
Time in closed arm before self-admin | 0.2 | 0.2 | 0.7 | -0.2 | 0.2 | 0.4 | -0.5 | 0.4 | -0.4 | 0.2 | -0.8 | 0.5 | 0.7 | -0.7 | -0.7 | 0.0 | -0.6 | 0.2 | -0.5 | -0.3 | 0.2 | 0.3 | -0.6 |
Ambulatory time after self-admin | 0.2 | 0.2 | 1.4 | 0.5 | -0.5 | -0.4 | 0.2 | -0.2 | -0.1 | 0.1 | -0.1 | 0.0 | 1.2 | -1.2 | -0.8 | -0.1 | 0.3 | -0.0 | -0.1 | -0.3 | -0.0 | 0.0 | -0.4 |
Bouts of movement, locomotor time 1 | 0.2 | 0.3 | 0.6 | -0.6 | 0.6 | 0.5 | -0.7 | 0.5 | -0.5 | 0.3 | -0.6 | 0.7 | -0.5 | 0.5 | -0.2 | -0.5 | -0.5 | 0.5 | -0.5 | -0.4 | 0.5 | 0.6 | -0.4 |
Distance moved, locomotor task time 1 | 0.2 | 0.3 | 1.2 | 0.0 | -0.0 | -1.1 | 0.3 | -0.2 | 0.1 | -0.1 | 0.3 | -0.7 | -1.0 | 1.0 | 0.4 | -0.8 | 0.3 | 0.2 | 0.2 | 0.1 | 0.2 | -0.1 | 0.3 |
Locomotion in novel chamber | 0.2 | 0.2 | 1.1 | -0.6 | 0.6 | 0.3 | -0.3 | 0.3 | 0.0 | -0.1 | 0.0 | 0.1 | -1.0 | 1.0 | 0.6 | 0.0 | -0.4 | 0.1 | 0.1 | 0.3 | 0.1 | 0.1 | 0.2 |
Latency to leave start box in cocaine runway | 0.2 | 0.2 | 0.7 | -0.4 | 0.4 | -0.5 | -0.5 | -0.2 | 0.2 | -0.4 | -0.7 | 0.9 | 0.5 | -0.4 | -0.6 | 0.4 | -0.6 | -0.1 | -0.1 | 0.0 | -0.5 | -0.3 | -0.1 |
Cu content in liver | 0.2 | 0.2 | 0.5 | -0.7 | 0.7 | 0.2 | -0.6 | 0.4 | -0.5 | 0.3 | -0.5 | 0.3 | -0.5 | 0.5 | -0.3 | -0.5 | -0.6 | 0.6 | -0.5 | -0.4 | 0.4 | 0.4 | -0.4 |
BMI without tail | 0.1 | 0.3 | 0.8 | 0.8 | -0.8 | -0.6 | 0.8 | -0.4 | 0.3 | -0.3 | 0.2 | -0.4 | 0.7 | -0.7 | -0.1 | 0.3 | 0.9 | -0.5 | 0.3 | 0.4 | -0.3 | -0.4 | 0.2 |
Body weight | 0.1 | 0.3 | 1.6 | 0.3 | -0.3 | 0.1 | 0.3 | 0.0 | -0.3 | 0.0 | -0.6 | 0.5 | 1.3 | -1.3 | -0.9 | -0.0 | 0.2 | 0.1 | -0.4 | -0.4 | 0.1 | 0.1 | -0.6 |
Liver weight, left | 0.1 | 0.2 | 0.6 | 0.2 | -0.2 | -0.1 | 0.3 | -0.4 | 0.4 | -0.8 | 0.3 | -0.2 | -0.0 | -0.0 | 0.5 | 0.6 | 0.2 | -0.4 | 0.4 | 0.5 | -0.5 | -0.4 | 0.4 |
Light reinforcement 1 | 0.1 | 0.3 | 1.2 | 0.1 | -0.1 | -0.2 | 0.1 | -0.6 | 0.3 | -0.6 | -0.3 | 0.5 | 1.1 | -1.1 | -0.5 | 0.7 | 0.2 | -0.5 | 0.1 | 0.2 | -0.5 | -0.6 | -0.0 |
Reaction time mean | 0.1 | 0.1 | 0.6 | 0.1 | -0.1 | -0.5 | 0.1 | 0.0 | -0.3 | 0.3 | -0.4 | 0.5 | 0.2 | -0.2 | -0.6 | -0.8 | 0.1 | 0.3 | -0.3 | -0.4 | 0.3 | 0.1 | -0.3 |
Reaction time mean AUC | 0.1 | 0.1 | 0.6 | 0.0 | -0.0 | -0.2 | -0.0 | 0.1 | -0.3 | 0.5 | -0.1 | 0.3 | -0.3 | 0.3 | -0.2 | -0.8 | -0.0 | 0.4 | -0.2 | -0.3 | 0.4 | 0.2 | -0.2 |
Cocaine response before conditioning | 0.1 | 0.2 | 0.6 | 0.1 | -0.1 | 0.0 | 0.1 | -0.6 | 0.5 | -0.3 | 0.2 | 0.0 | 0.3 | -0.3 | 0.2 | 0.8 | 0.2 | -0.6 | 0.4 | 0.6 | -0.6 | -0.7 | 0.4 |
Pavlov. Cond. magazine entry latency | 0.1 | 0.1 | 0.3 | 0.3 | -0.3 | 0.6 | 0.2 | 0.1 | -0.0 | 0.0 | 0.4 | -0.6 | -0.2 | 0.2 | 0.6 | 0.4 | 0.2 | -0.2 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
Pavlov. Cond. latency score | 0.1 | 0.1 | 0.7 | 0.1 | -0.1 | 0.9 | 0.0 | 0.4 | -0.3 | 0.3 | 0.2 | -0.6 | -0.3 | 0.3 | 0.4 | 0.2 | 0.0 | 0.1 | -0.1 | -0.2 | 0.4 | 0.5 | -0.1 |
Pavlov. Cond. magazine entry number | 0.1 | 0.1 | 0.3 | -0.2 | 0.2 | -0.5 | -0.1 | -0.2 | 0.2 | -0.1 | 0.1 | 0.0 | -0.6 | 0.6 | 0.2 | -0.2 | -0.1 | 0.0 | 0.2 | 0.2 | -0.2 | -0.3 | 0.3 |
Conditioned locomotion | 0.1 | 0.1 | 0.6 | 0.1 | -0.1 | -0.3 | -0.2 | -0.2 | 0.4 | -0.1 | 0.8 | -0.5 | -0.4 | 0.4 | 0.5 | 0.3 | -0.1 | -0.2 | 0.4 | 0.4 | -0.4 | -0.2 | 0.5 |
Intermitt. access escalation Index | 0.1 | 0.1 | 0.3 | 0.5 | -0.5 | -0.3 | 0.3 | -0.5 | 0.2 | -0.3 | 0.5 | -0.5 | -0.1 | 0.1 | 0.4 | 0.2 | 0.3 | -0.3 | 0.3 | 0.4 | -0.1 | -0.4 | 0.3 |
Locomotion distance, session 2 | 0.1 | 0.2 | 0.8 | -0.4 | 0.4 | 0.3 | -0.5 | -0.6 | 0.4 | -0.3 | -0.3 | 0.8 | 0.1 | -0.1 | 0.1 | 0.9 | -0.4 | -0.3 | 0.2 | 0.5 | -0.6 | -0.6 | 0.2 |
Condit. Reinf. active responses | 0.1 | 0.1 | 0.3 | -0.4 | 0.4 | 0.4 | -0.4 | -0.0 | -0.1 | 0.0 | -0.3 | 0.5 | -0.0 | 0.0 | -0.1 | 0.1 | -0.5 | 0.1 | -0.2 | -0.0 | 0.1 | -0.0 | -0.2 |
Time in familiar zone, hab. session 1 | 0.1 | 0.1 | 0.6 | -0.1 | 0.1 | 0.4 | -0.1 | -0.4 | 0.3 | -0.2 | -0.1 | 0.5 | 0.3 | -0.3 | 0.1 | 0.8 | -0.1 | -0.4 | 0.2 | 0.3 | -0.4 | -0.4 | 0.2 |
Time in novel zone, hab. session 2 | 0.1 | 0.1 | 0.6 | -0.0 | 0.0 | -0.8 | -0.2 | -0.0 | 0.0 | -0.2 | 0.1 | -0.0 | -0.7 | 0.7 | 0.2 | -0.4 | -0.2 | 0.2 | 0.1 | 0.1 | 0.0 | -0.0 | 0.2 |
Novel to familiar place preference ratio | 0.1 | 0.1 | 0.7 | -0.2 | 0.2 | -0.8 | -0.1 | -0.4 | 0.3 | -0.1 | -0.2 | 0.3 | 0.1 | -0.1 | -0.4 | -0.2 | -0.2 | -0.0 | 0.1 | 0.2 | -0.3 | -0.4 | 0.1 |
Total zone transitions, NPP test | 0.1 | 0.2 | 0.9 | -0.0 | 0.0 | 0.8 | -0.1 | -0.4 | 0.3 | -0.1 | 0.3 | -0.1 | -0.1 | 0.1 | 0.6 | 1.0 | -0.0 | -0.4 | 0.3 | 0.4 | -0.4 | -0.4 | 0.3 |
Pavlov. Cond. change in total contacts | 0.1 | 0.1 | 0.3 | -0.4 | 0.4 | 0.1 | -0.5 | -0.2 | 0.0 | -0.4 | -0.2 | 0.3 | -0.1 | 0.1 | 0.0 | 0.3 | -0.6 | 0.0 | -0.1 | 0.1 | -0.2 | -0.2 | -0.0 |
Pavlov. Cond. latency score | 0.1 | 0.1 | 0.2 | 0.1 | -0.1 | -0.3 | 0.1 | -0.3 | 0.3 | -0.4 | 0.3 | -0.3 | -0.2 | 0.2 | 0.3 | 0.3 | 0.1 | -0.2 | 0.3 | 0.3 | -0.4 | -0.3 | 0.3 |
Pavlov. Cond. magazine entry number | 0.1 | 0.1 | 0.4 | -0.3 | 0.3 | 0.6 | -0.2 | 0.3 | -0.3 | 0.4 | -0.3 | 0.3 | -0.1 | 0.1 | -0.1 | -0.1 | -0.1 | 0.2 | -0.3 | -0.3 | 0.4 | 0.3 | -0.3 |
Pavlov. Cond. response bias | 0.1 | 0.1 | 0.3 | 0.0 | -0.0 | -0.1 | -0.1 | -0.3 | 0.3 | -0.4 | 0.3 | -0.3 | -0.5 | 0.5 | 0.5 | 0.3 | -0.2 | -0.2 | 0.3 | 0.3 | -0.3 | -0.3 | 0.4 |
Bone: apparent density | 0.1 | 0.1 | 0.5 | -0.2 | 0.2 | -0.7 | -0.1 | -0.6 | 0.3 | -0.5 | -0.3 | 0.5 | 0.4 | -0.4 | -0.4 | 0.2 | -0.0 | -0.2 | 0.1 | 0.3 | -0.5 | -0.5 | 0.1 |
Bone: cortical area | 0.1 | 0.2 | 0.9 | -0.3 | 0.3 | 1.0 | -0.3 | 0.4 | -0.5 | 0.5 | -0.1 | 0.0 | -0.5 | 0.5 | 0.3 | -0.2 | -0.3 | 0.4 | -0.3 | -0.3 | 0.5 | 0.5 | -0.3 |
Bone: elastic work | 0.1 | 0.1 | 0.3 | 0.1 | -0.1 | -0.1 | 0.1 | 0.3 | -0.2 | 0.2 | 0.2 | -0.2 | -0.5 | 0.5 | 0.2 | -0.6 | 0.1 | 0.2 | -0.0 | -0.2 | 0.3 | 0.3 | -0.0 |
Bone: trabecular number | 0.1 | 0.2 | 0.4 | -0.2 | 0.2 | -0.5 | -0.1 | -0.6 | 0.3 | -0.5 | -0.3 | 0.6 | 0.5 | -0.5 | -0.4 | 0.4 | -0.1 | -0.3 | 0.1 | 0.3 | -0.6 | -0.6 | 0.1 |
Time in open arm before self-admin | 0.1 | 0.1 | 0.3 | 0.1 | -0.1 | -0.1 | 0.3 | -0.5 | 0.4 | -0.4 | 0.5 | -0.1 | -0.1 | 0.0 | 0.3 | 0.4 | 0.4 | -0.4 | 0.4 | 0.3 | -0.4 | -0.5 | 0.4 |
Delta time to tail flick, test, before/after SA | 0.1 | 0.1 | 0.2 | 0.4 | -0.4 | 0.1 | 0.4 | -0.0 | 0.0 | -0.1 | 0.2 | -0.3 | 0.3 | -0.3 | 0.1 | 0.1 | 0.4 | -0.1 | 0.1 | 0.1 | 0.1 | -0.0 | 0.0 |
Total resting periods, locomotor time 1 | 0.1 | 0.1 | 0.3 | -0.3 | 0.3 | 0.5 | -0.4 | 0.3 | -0.3 | 0.3 | -0.3 | 0.4 | -0.4 | 0.4 | 0.1 | -0.3 | -0.2 | 0.3 | -0.3 | -0.2 | 0.4 | 0.5 | -0.2 |
Progressive ratio | 0.1 | 0.1 | 0.3 | 0.0 | -0.0 | 0.2 | -0.2 | 0.4 | -0.4 | 0.2 | -0.2 | -0.2 | -0.2 | 0.3 | -0.0 | -0.5 | -0.3 | 0.4 | -0.3 | -0.2 | 0.5 | 0.3 | -0.3 |
Length with tail | 0.0 | 0.1 | 0.4 | 0.2 | -0.2 | -0.4 | 0.2 | -0.3 | 0.2 | -0.6 | 0.3 | -0.3 | -0.3 | 0.3 | 0.5 | 0.2 | 0.1 | -0.2 | 0.3 | 0.4 | -0.2 | -0.3 | 0.3 |
Length without tail | 0.0 | 0.0 | 0.1 | 0.1 | -0.1 | 0.2 | 0.0 | 0.1 | -0.1 | 0.0 | -0.0 | -0.1 | 0.2 | -0.2 | -0.1 | -0.0 | -0.1 | 0.1 | -0.1 | -0.2 | 0.0 | 0.1 | -0.1 |
Tibia length | 0.0 | 0.0 | 0.1 | 0.4 | -0.4 | -0.2 | -0.0 | -0.2 | 0.1 | -0.3 | 0.0 | -0.2 | 0.3 | -0.3 | -0.1 | 0.2 | -0.0 | -0.2 | 0.1 | 0.1 | -0.3 | -0.2 | 0.0 |
Reaction time omissions | 0.0 | 0.0 | 0.1 | 0.3 | -0.3 | 0.1 | 0.3 | -0.1 | 0.1 | 0.4 | 0.1 | -0.0 | 0.3 | -0.3 | -0.1 | 0.1 | 0.3 | -0.2 | 0.1 | -0.0 | -0.1 | -0.0 | 0.0 |
Social time | 0.0 | 0.1 | 0.2 | 0.3 | -0.3 | 0.3 | 0.2 | 0.4 | -0.2 | -0.0 | -0.0 | 0.0 | 0.4 | -0.4 | -0.1 | 0.1 | 0.1 | 0.0 | -0.1 | -0.2 | 0.1 | 0.3 | -0.2 |
Baseline Anxiety | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | 0.2 | -0.3 | -0.1 | -0.1 | 0.1 | 0.2 | 0.2 | -0.2 | 0.2 | -0.0 | -0.1 | -0.2 | 0.0 | -0.1 | -0.1 | 0.1 | -0.1 | -0.1 |
Condit. Reinf. active minus inactive responses | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | -0.0 | 0.2 | -0.1 | 0.1 | 0.0 | 0.3 | -0.3 | -0.0 | 0.0 | 0.2 | -0.0 | 0.1 | -0.1 | 0.1 | 0.2 | 0.0 | -0.1 | 0.1 |
Pavlov. Cond. index score | 0.0 | 0.0 | 0.1 | 0.0 | -0.0 | -0.2 | -0.1 | -0.2 | 0.2 | -0.3 | 0.2 | -0.2 | -0.3 | 0.3 | 0.3 | 0.1 | -0.1 | -0.1 | 0.2 | 0.2 | -0.2 | -0.2 | 0.2 |
Pavlov. Cond. lever-magazine prob. diff. | 0.0 | 0.0 | 0.1 | 0.0 | -0.0 | -0.1 | -0.1 | -0.1 | 0.2 | -0.2 | 0.2 | -0.2 | -0.3 | 0.2 | 0.2 | 0.1 | -0.1 | -0.1 | 0.1 | 0.2 | -0.2 | -0.1 | 0.2 |
Bone: stiffness | 0.0 | 0.0 | 0.2 | 0.1 | -0.1 | 0.1 | 0.1 | 0.2 | -0.0 | 0.1 | 0.2 | -0.4 | -0.3 | 0.3 | 0.3 | -0.1 | 0.2 | 0.0 | 0.0 | -0.1 | 0.1 | 0.1 | 0.1 |
Breakpoint value in progressive ratio session | 0.0 | 0.1 | 0.4 | 0.0 | -0.0 | 0.6 | 0.0 | -0.3 | 0.0 | 0.2 | 0.4 | -0.2 | -0.1 | 0.1 | 0.4 | 0.4 | 0.0 | -0.0 | 0.1 | 0.2 | -0.0 | -0.2 | 0.1 |
Distance traveled before self-admin | 0.0 | 0.0 | 0.2 | -0.1 | 0.1 | 0.5 | -0.1 | 0.2 | -0.3 | 0.2 | 0.0 | -0.0 | 0.2 | -0.2 | -0.1 | 0.1 | -0.1 | 0.2 | -0.2 | -0.2 | 0.2 | 0.3 | -0.3 |
Co content in liver | 0.0 | 0.0 | 0.2 | 0.0 | -0.0 | -0.1 | 0.1 | -0.0 | 0.0 | -0.2 | -0.3 | 0.1 | 0.5 | -0.5 | -0.4 | 0.1 | 0.1 | -0.1 | -0.1 | 0.1 | -0.1 | -0.0 | -0.1 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.