Hub : Genes

Pan3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000000942	0.17	0.1	4.4e-11	0.09	0.08	0.08	0.08	8.9e-10	6.8e-09	4.3e-09	4.0e-09
2	Adipose	intron excision ratio	chr12:7535879:7560158	0.04	0.03	5.4e-03	0.03	0.02	0.01	0.02	5.6e-04	1.4e-03	3.6e-02	1.4e-03
3	Brain	gene expression	ENSRNOG00000000942	0.08	0.05	1.5e-04	0.05	0.05	0.02	0.04	3.4e-05	2.2e-05	8.0e-03	6.8e-05
4	Brain	mRNA stability	ENSRNOG00000000942	0.05	0.04	2.5e-04	0.04	0.04	0.03	0.04	1.0e-04	6.3e-05	4.7e-04	1.1e-04
5	OFC	gene expression	ENSRNOG00000000942	0.17	0.1	4.7e-03	0.06	0.12	0.1	0.09	1.6e-02	8.1e-04	2.1e-03	4.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
BMI with tail	1.2	3.8	8.0	-1.7	-1.9	-2.1	-0.1	-2.8
BMI without tail	2.2	4.6	7.4	1.0	-2.2	-2.7	2.6	-1.7
Body weight	1.5	6.3	11.3	2.4	-2.5	-3.4	2.2	-1.9
Epididymis fat weight	2.5	5.8	12.4	-1.0	-2.2	-3.2	-0.3	-3.5
Glucose	0.2	0.3	1.1	1.1	-0.1	-0.7	-0.2	-0.4
Heart weight	0.9	1.3	3.0	1.7	1.1	0.1	0.8	1.2
Left kidney weight	0.9	2.4	6.1	1.5	-1.0	-2.5	0.8	-1.5
Right kidney weight	2.3	6.5	13.4	1.2	-2.5	-3.7	2.1	-2.6
Tail length	2.5	7.7	21.9	4.7	-0.5	-1.4	3.6	1.3
Length with tail	2.4	8.8	31.4	5.6	-0.1	-1.2	2.8	1.7
Length without tail	0.4	0.8	3.0	1.7	-0.5	-0.7	0.2	0.0
Liver weight, left	0.9	1.5	3.3	-1.0	-1.8	-1.1	0.3	-1.4
Liver weight, right	2.2	3.7	6.3	0.9	-2.1	-2.5	2.1	-1.6
Parametrial fat weight	0.3	0.7	1.2	0.1	-1.1	-1.1	0.1	-1.0
Retroperitoneal fat weight	1.2	4.1	7.1	-0.2	-2.4	-2.7	1.0	-2.5
Intraocular pressure	2.1	3.0	6.3	-1.7	-1.6	-1.6	-0.9	-2.5
Extensor digitorum longus weight	0.3	1.1	2.9	-0.0	-1.7	-1.1	0.5	-1.1
Soleus weight	0.8	2.4	4.6	0.4	-2.1	-1.5	2.0	-0.9
Tibialis anterior weight	0.3	1.2	2.1	0.4	-1.5	-1.4	0.8	-1.0
Tibia length	0.6	1.7	3.2	1.5	-0.9	-1.5	1.8	-0.5
Number of licking bursts	0.3	0.3	0.8	0.7	0.1	0.0	0.9	0.5
Food consumed during 24 hour testing period	0.3	0.3	1.1	1.0	0.3	0.2	-0.4	0.6
Times rat made contact with spout	0.5	0.6	2.4	1.6	-0.2	-0.2	0.5	0.6
Mean time between licks in bursts	0.7	1.0	2.4	-1.0	0.6	1.5	-0.5	1.1
Mean num. licks in bursts	0.2	0.3	1.1	0.1	0.2	0.4	-1.1	0.2
Std. dev. time between licks in bursts	1.4	1.7	2.8	0.8	1.7	1.4	-0.9	1.5
Water consumed over 24 hours	1.1	1.3	4.2	2.0	-0.4	-1.0	1.1	0.2
Indifference point 0 sec	0.1	0.2	0.8	0.5	-0.3	-0.3	0.9	-0.0
Indifference point AUC	0.5	0.6	0.8	0.8	0.7	0.8	-0.7	0.9
Indifference point function ln k	0.5	0.7	1.9	0.9	-0.7	-0.3	1.4	0.4
Indifference point function log k	0.5	0.7	1.9	0.9	-0.7	-0.3	1.4	0.4
Delay discounting total patch changes 0 sec	0.2	0.2	0.7	0.6	-0.1	-0.0	0.8	0.3
Delay discounting total patch changes 12 sec	0.2	0.2	0.5	0.7	-0.2	0.0	0.6	0.4
Delay discounting total patch changes 18 sec	0.3	0.4	1.0	-1.0	0.3	0.2	-0.9	-0.4
Delay discounting total patch changes 24 sec	0.1	0.1	0.4	0.6	-0.0	-0.1	0.4	0.2
Delay discounting total patch changes 6 sec	0.7	1.0	2.2	1.2	-0.9	-0.8	1.5	-0.0
Delay discounting time to switch 0 sec	0.9	1.4	3.0	-1.4	-0.7	-1.2	-0.0	-1.7
Delay discounting water rate 0 sec	0.2	0.3	0.8	0.7	0.2	0.6	0.1	0.9
Delay discounting water rate 12 sec	0.6	0.9	2.4	0.5	-1.6	-0.7	1.2	-0.2
Delay discounting water rate 18 sec	0.6	0.8	1.7	1.3	0.1	0.4	1.0	1.0
Delay discounting water rate 24 sec	0.1	0.1	0.2	0.1	-0.4	0.3	0.4	0.4
Delay discounting water rate 6 sec	0.6	0.9	2.0	-0.4	-0.1	1.4	0.7	1.4
Locomotor activity	1.0	1.6	4.1	1.1	-1.1	-1.2	2.0	-0.3
Locomotor testing distance	0.2	0.3	0.5	-0.5	0.6	0.7	0.1	0.5
Locomotor testing rearing	0.2	0.3	1.1	-1.0	0.3	0.5	-0.1	0.0
Light reinforcement 1	1.3	2.3	4.5	-0.0	1.9	2.1	-0.7	1.7
Light reinforcement 2	0.6	0.9	1.7	-1.0	1.0	0.8	-1.3	-0.0
Reaction time number correct	0.1	0.1	0.2	0.4	-0.0	-0.0	0.4	0.2
Reaction time mean minus median	0.4	0.5	1.5	1.2	-0.4	-0.3	0.7	0.3
Reaction time mean minus median AUC	0.3	0.4	1.0	1.0	-0.6	-0.5	0.4	0.0
Reaction time num false alarms	0.6	0.8	1.7	1.3	0.6	0.3	0.8	1.0
Reaction time num false alarms AUC	0.3	0.5	1.2	1.1	0.4	-0.1	0.8	0.6
Reaction time trials correct on left	0.1	0.1	0.2	0.4	-0.0	-0.0	0.4	0.2
Reaction time trials on left	0.1	0.1	0.2	0.4	0.0	0.0	0.4	0.3
Reaction time mean	0.3	0.4	0.8	-0.9	0.6	0.7	-0.8	0.2
Reaction time mean AUC	0.5	0.6	0.9	-0.9	0.7	0.9	-1.0	0.4
Median of all reaction times	1.0	1.4	2.6	-1.6	1.0	1.2	-1.3	0.3
Reaction time omissions	0.0	0.0	0.0	-0.0	0.2	0.2	-0.2	0.1
Reaction time false alarm rate	0.2	0.2	0.7	0.8	0.2	-0.1	0.5	0.3
Reaction time premature initiation rate	0.6	0.9	3.5	1.9	0.3	-0.4	0.7	0.4
Reaction time premature initiations	0.8	1.1	4.3	2.1	0.3	-0.4	0.9	0.6
Std. dev. reaction times	0.1	0.2	0.4	0.4	-0.7	-0.4	0.4	-0.2
Reaction time trials completed	0.1	0.1	0.2	0.4	0.0	0.0	0.4	0.3
Reaction time trials AUC	0.1	0.1	0.3	0.2	-0.2	-0.3	0.6	-0.0
Social response proportion	0.3	0.4	0.8	0.8	-0.0	-0.0	0.9	0.5
Social responses	2.1	2.7	5.5	2.4	-0.1	0.5	2.1	1.8
Social time	0.4	0.5	0.6	-0.5	-0.7	-0.6	0.8	-0.8
Conditioned locomotion	0.5	0.5	2.0	-0.2	1.4	0.6	-0.3	0.5
Cocaine response after cond. corrected	0.3	0.4	1.0	-0.5	-0.1	-0.8	0.0	-1.0
Cocaine response after cond. not corrected	0.1	0.2	0.3	-0.3	-0.2	-0.5	0.3	-0.6
Cocaine response before conditioning	0.7	0.9	1.6	1.3	-0.3	0.5	1.0	1.2
Saline control response	1.1	1.4	3.1	1.8	0.6	0.4	1.3	1.3
Condit. Reinf. active minus inactive responses	0.8	1.0	2.6	1.6	0.3	-0.0	1.3	0.9
Condit. Reinf. active-inactive response ratio	0.9	0.9	2.6	1.6	0.2	-0.2	1.2	0.7
Condit. Reinf. active responses	1.3	1.8	4.9	2.2	0.7	0.4	1.3	1.5
Condit. Reinf. inactive responses	0.6	0.8	1.9	1.4	0.3	0.4	0.7	1.0
Condit. Reinf. lever presses	1.6	2.2	4.2	1.4	-1.2	-1.7	2.1	-0.8
Condit. Reinf. lever reinforcers received	1.2	1.7	4.9	2.2	0.4	0.1	1.5	1.2
Pavlov. Cond. lever latency	0.5	0.7	1.5	-1.2	-0.0	0.8	-1.0	0.2
Pavlov. Cond. magazine entry latency	1.3	1.5	2.7	-0.1	-1.4	-1.7	1.1	-1.4
Pavlov. Cond. change in total contacts	1.4	2.0	3.8	0.8	-1.4	-1.6	2.0	-0.9
Pavlov. Cond. index score	1.4	1.8	3.2	1.0	-1.1	-1.8	1.6	-1.0
Pavlov. Cond. latency score	1.1	1.4	2.4	1.0	-0.9	-1.6	1.4	-0.9
Pavlov. Cond. lever contacts	0.3	0.4	0.7	0.8	0.0	-0.8	0.8	-0.4
Pavlov. Cond. magazine entry number	2.0	2.4	4.5	0.1	1.7	2.1	-1.2	1.8
Pavlov. Cond. intertrial magazine entries	2.8	3.6	7.3	1.8	1.8	2.1	0.1	2.7
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.8	1.0	-1.0	-1.7	1.4	-1.0
Pavlov. Cond. response bias	0.8	1.0	2.0	0.6	-0.7	-1.3	1.4	-0.8
Conditioned reinforcement - actives	0.5	0.5	0.9	0.5	-0.6	-0.9	0.9	-0.5
Conditioned reinforcement - inactives	0.5	0.5	0.8	0.9	-0.4	-0.8	0.9	-0.5
Conditioned locomotion	0.9	1.1	2.2	1.4	-0.7	-0.6	1.5	0.3
Intermittent access intake day 1-15 change	0.4	0.4	1.0	-0.9	1.0	0.3	-0.4	-0.2
Intermittent access intake escalation	0.7	0.7	2.1	-0.8	1.5	0.6	-0.4	0.3
Intermittent access intake escalation 2	2.2	2.1	5.1	-1.0	2.3	1.6	-0.9	1.0
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	0.6	0.2	0.2	0.4	0.2
Intermitt. access day 15 inactive lever presses	1.2	1.4	2.3	0.8	-1.5	-1.3	1.2	-0.9
Intermitt. access escalation Index	0.5	0.5	1.6	-1.3	-0.1	0.6	-0.7	-0.0
Intermittent access day 1 total infusions	1.0	1.1	2.0	0.5	-1.2	-1.4	1.3	-0.7
Intermittent access day 15 total infusions	0.4	0.5	1.0	-0.1	-0.6	-1.0	0.9	-0.6
Intermittent access terminal intake (last 3 days)	0.6	0.7	1.1	-0.6	-0.8	-1.1	0.6	-0.9
Intermittent access total infusions	1.1	1.2	2.2	0.1	-1.2	-1.5	1.2	-0.9
Intermittent access day 1 locomotion	0.7	0.7	1.3	0.4	-0.7	-1.1	1.1	-0.5
Intermittent access day 15 total locomotion	2.1	2.3	4.8	1.0	-1.2	-2.2	1.5	-1.4
Intermittent access total locomotion	1.6	1.8	4.0	0.8	-1.0	-2.0	1.3	-1.3
Intermittent access standard deviation	0.4	0.4	0.8	-0.2	-0.5	-0.9	0.2	-0.9
Cocaine induced anxiety	0.3	0.4	1.0	0.4	-0.3	-1.0	0.4	-0.8
Post-drug Anxiety	0.2	0.3	0.7	-0.1	-0.1	-0.7	-0.2	-0.8
Baseline Anxiety	0.6	0.6	1.3	-1.2	0.4	0.6	-1.1	-0.0
Lifetime Intake	1.0	1.1	2.1	0.2	-1.2	-1.4	1.2	-0.8
Incentive Sensitization - Responses	1.6	1.6	4.0	0.2	-0.7	-2.0	1.1	-1.5
Incentive Sensitization - Breakpoint	1.4	1.4	3.7	0.2	-0.7	-1.9	1.0	-1.4
Progressive ratio test 1 active lever presses	3.4	3.5	8.9	1.2	-1.7	-1.9	3.0	-0.6
Progressive ratio test 1 breakpoint	2.5	2.6	7.0	1.1	-1.5	-1.5	2.6	-0.3
Progressive ratio test 1 inactive lever presses	1.3	1.3	3.6	1.4	-0.7	-0.8	1.9	0.2
Progressive ratio test 2 active lever presses	2.5	2.6	5.6	0.6	-1.1	-2.4	2.0	-1.4
Progressive ratio test 2 breakpoint	1.8	2.0	3.9	0.7	-1.0	-2.0	1.9	-1.0
Progressive ratio test 2 inactive lever presses	2.5	2.9	6.4	1.5	-1.1	-2.0	2.5	-0.7
Total sessions with >9 infusions	1.3	1.4	3.1	1.1	-1.0	-1.2	1.8	-0.3
Short access day 1 total inactive lever presses	2.0	2.2	5.8	2.4	0.5	0.2	1.6	1.6
Short access day 10 total inactive lever presses	1.0	1.1	2.0	1.2	1.1	1.0	-0.2	1.4
Short access day 1 total infusions	0.1	0.1	0.2	0.0	0.2	-0.0	0.4	0.3
Short access day 10 total infusions	1.0	1.0	2.8	1.1	-0.9	-0.7	1.7	0.2
Short access total infusions	0.7	0.8	1.4	0.5	-1.0	-1.1	1.2	-0.5
Short access day 1 locomotion	0.3	0.3	0.6	0.5	-0.3	-0.7	0.8	-0.4
Short access day 10 total locomotion	0.5	0.6	1.1	1.0	1.1	0.2	0.4	0.8
Short access total locomotion	0.4	0.4	1.0	0.9	-0.4	-0.1	1.0	0.4
Compulsive drug intake	0.5	0.5	0.8	-0.4	0.9	0.9	-0.8	0.4
One hour access (0.3 mA shock)	0.4	0.4	0.7	0.8	0.8	-0.1	0.8	0.5
One hour access (shock baseline)	0.7	0.8	1.9	0.8	-0.6	-1.1	1.4	-0.3
Number of responses in last shaping day	0.2	0.2	0.4	-0.7	-0.5	0.0	0.0	-0.2
Context. condit. distance diff. score	0.8	1.0	2.6	0.6	0.7	1.3	0.1	1.6
Locomotion velocity, session 1	1.0	1.0	3.1	1.7	0.8	0.4	0.0	1.2
Locomotion distance, session 1	0.4	0.5	1.0	0.6	0.8	0.3	-1.0	0.3
Locomotion velocity, session 2	0.6	0.7	1.8	1.3	1.1	-0.0	-0.4	0.5
Locomotion distance, session 2	0.4	0.6	2.0	1.4	0.5	-0.8	-0.3	-0.3
Locomotion velocity, session 3	0.2	0.2	0.4	0.6	0.5	0.1	-0.3	0.3
Locomotion distance, session 3	0.4	0.4	0.9	0.9	-0.3	-0.8	0.6	-0.2
Stereotopy head waving bouts, day 3	0.8	1.0	2.5	0.5	0.8	1.3	0.1	1.6
Stereotopy head waving duration, day 3	0.4	0.5	1.3	-0.5	0.3	1.2	-0.3	0.9
Locomotion velocity, session 7	0.3	0.3	0.5	0.6	-0.7	-0.3	0.6	0.2
Locomotion distance, session 7	0.1	0.2	0.4	0.5	0.1	0.5	-0.3	0.6
Stereotopy head waving bouts, day 7	0.7	0.7	2.0	1.1	-0.4	-0.6	1.4	0.2
Stereotopy head waving duration, day 7	0.4	0.5	1.6	0.8	-0.3	-0.5	1.3	0.1
Locomotion velocity, session 8	1.2	1.5	2.7	1.6	1.0	1.0	0.2	1.7
Locomotion distance, session 8	1.1	1.6	2.3	1.4	1.4	1.1	-0.7	1.5
Degree of sensitization distance	1.2	1.2	2.5	-0.1	0.9	1.6	-0.9	1.3
Degree of sensitization stereotypy	0.9	1.0	1.9	0.1	-1.0	-1.4	0.9	-1.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.8	0.1	0.4	-0.1	0.2
Condit. Reinf. active-inactive response ratio	1.3	1.4	5.0	-2.2	0.1	0.4	-1.2	-0.6
Condit. Reinf. active responses	0.1	0.2	0.3	-0.4	0.4	0.6	-0.2	0.4
Condit. Reinf. inactive responses	0.4	0.5	1.9	1.4	-0.1	-0.1	0.6	0.6
Incentive salience index mean	0.2	0.3	0.7	0.3	-0.6	-0.5	0.8	-0.1
Condit. Reinf. lever presses	0.9	1.2	2.1	0.3	-1.5	-1.3	1.1	-0.9
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.2	0.4	0.0	-0.1	-0.0
Time in novel zone, hab. session 1	0.8	0.7	1.8	-0.4	-1.3	-0.8	0.7	-0.8
Total zone transitions, hab. session 1	1.4	2.0	5.9	2.4	-0.4	-0.4	1.7	1.0
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.7	0.4	0.4	0.1	0.7
Locomotion velocity, hab. session 1	0.7	0.9	1.5	0.9	1.0	1.1	-0.5	1.2
Time in familiar zone, hab. session 2	0.5	0.5	1.7	-0.6	0.5	0.4	-1.3	-0.1
Time in novel zone, hab. session 2	0.5	0.5	1.9	0.3	-0.6	-0.0	1.4	0.5
Total zone transitions, hab. session 2	0.3	0.3	0.8	0.4	0.6	-0.4	-0.9	-0.4
Total locomotion distance, hab. session 2	1.1	1.5	4.8	-0.0	1.5	0.6	-2.2	0.2
Locomotion velocity, hab. session 2	1.1	1.5	4.9	0.0	1.5	0.6	-2.2	0.2
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.3	-0.5	-0.3	-0.0	-0.3
Novelty place preference	0.2	0.2	0.4	-0.3	-0.6	-0.4	0.1	-0.4
Time in novel zone, NPP test	0.2	0.2	0.5	-0.1	-0.7	-0.4	0.3	-0.3
Total zone transitions, NPP test	0.3	0.5	2.0	1.4	0.4	-0.3	-0.2	0.3
Total locomotion distance, NPP test	0.3	0.4	1.3	1.1	0.5	-0.0	-0.6	0.3
Locomotion velocity, NPP test	0.2	0.3	1.1	1.0	0.4	-0.2	-0.5	0.1
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.7	0.4	0.0	-0.4	-0.3
Pavlov. Cond. magazine entry latency	1.1	1.4	3.7	1.9	-0.6	-0.4	1.5	0.7
Pavlov. Cond. change in total contacts	0.6	0.6	1.4	1.2	-0.8	-0.4	1.0	0.4
Pavlov. Cond. index score	0.8	1.0	2.4	1.6	-0.8	-0.6	1.2	0.4
Pavlov. Cond. latency score	0.6	0.7	2.0	1.4	-0.5	-0.4	1.0	0.4
Pavlov. Cond. lever contacts	0.5	0.6	1.0	0.8	-1.0	-0.6	0.9	-0.1
Pavlov. Cond. magazine entry number	1.5	1.9	4.8	-2.2	1.1	0.9	-1.7	-0.5
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.3	-1.1	1.0	1.1	-0.8	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.7	1.3	-0.8	-0.5	1.0	0.3
Pavlov. Cond. response bias	1.0	1.3	2.5	1.6	-1.2	-0.7	1.4	0.3
Bone: apparent density	2.3	3.8	8.9	-1.7	-1.6	-2.1	-0.5	-3.0
Bone surface	2.3	4.0	7.9	-1.1	-2.3	-2.4	0.2	-2.8
Bone volume	3.1	5.3	11.1	-1.9	-2.4	-2.5	-0.3	-3.3
Bone: connectivity density	0.7	1.1	2.3	-0.5	-1.0	-1.3	-0.1	-1.5
Bone: cortical apparent density	1.3	1.6	5.2	-2.3	-0.2	-0.3	-1.0	-1.3
Bone: cortical area	3.0	4.6	7.2	0.2	-2.7	-2.5	2.5	-1.8
Bone: cortical porosity	0.6	0.6	1.3	1.1	0.8	0.6	0.1	1.0
Bone: cortical porosity	0.8	0.8	1.5	1.2	0.8	0.7	0.3	1.2
Bone: cortical thickness	1.9	3.1	4.6	-0.9	-2.1	-2.0	1.3	-2.0
Bone: cortical thickness	0.0	0.0	0.0	0.2	0.1	0.0	-0.1	0.1
Bone: cortical tissue density	1.4	1.9	5.9	-2.4	-0.1	-0.2	-1.3	-1.3
Bone: elastic displacement	3.0	3.3	7.6	-0.0	2.8	1.8	-2.0	1.3
Bone: elastic work	0.9	1.1	2.9	0.9	1.7	0.6	-1.0	0.8
Bone: endosteal estimation	0.4	0.9	2.4	1.5	0.2	-0.3	1.3	0.6
Bone: endosteal perimeter	1.1	2.3	4.7	1.6	-1.2	-1.5	2.2	-0.4
Bone: final force	0.5	0.8	2.6	0.8	-0.4	-0.9	1.6	-0.2
Bone: final moment	0.4	0.7	2.2	0.6	-0.3	-0.8	1.5	-0.3
Bone: marrow area	0.4	0.9	2.4	1.5	0.1	-0.3	1.3	0.6
Bone: maximum diameter	1.9	3.5	5.5	0.6	-2.3	-2.3	2.1	-1.5
Bone: maximum force	1.2	2.2	4.0	1.0	-1.4	-1.7	2.0	-0.9
Bone: maximum moment	1.1	1.9	3.3	0.7	-1.4	-1.7	1.8	-1.0
Bone: minimum diameter	0.7	1.2	3.9	1.2	-0.7	-0.5	2.0	0.3
Bone: periosteal estimation	1.1	2.3	4.9	1.1	-1.6	-1.6	2.2	-0.7
Bone: periosteal perimeter	1.2	2.1	4.2	1.2	-1.6	-1.4	2.0	-0.5
Bone: post-yield work	1.4	1.9	3.4	-1.2	-1.9	-1.3	0.5	-1.7
Bone: stiffness	1.7	2.7	6.4	1.8	-1.5	-1.3	2.5	-0.0
Bone: tissue strength	0.7	0.7	1.0	-0.8	-0.6	-0.8	1.0	-0.9
Bone: trabecular number	1.0	1.5	3.2	-0.7	-1.3	-1.5	0.2	-1.8
Bone: trabecular spacing	0.8	1.1	2.0	-0.1	1.4	1.3	-0.7	1.1
Bone: trabecular thickness	2.5	3.1	6.5	-1.3	-1.8	-2.0	-0.2	-2.5
Bone: trabecular tissue density	0.7	0.9	3.3	1.8	0.0	-0.6	0.9	0.4
Breakpoint value in progressive ratio session	0.8	0.9	3.4	0.4	-1.8	-0.6	0.4	-0.4
Distance traveled before self-admin	2.1	2.3	4.4	-1.2	1.1	2.1	-1.8	1.1
Distance traveled after self-admin	0.2	0.2	0.4	-0.0	-0.1	0.6	0.2	0.7
Delta time in closed arm before/after self-admin	1.7	1.7	3.8	1.9	-0.7	-0.7	1.9	0.2
Delta time in open arm before/after self-admin	1.5	1.4	4.3	-1.0	0.9	1.0	-2.1	-0.1
Diff in mean of infusions in LGA sessions	0.7	0.8	2.2	-0.8	-1.5	-0.4	-0.3	-0.8
Extinction: sum of active levers before priming	0.5	0.5	1.8	0.1	0.5	0.6	-1.3	0.0
Active lever presses in extinction session 6	1.1	1.1	3.0	-0.9	0.3	1.2	-1.7	0.2
Delta distance traveled before/after self-admin	0.7	0.7	2.5	0.8	-0.5	-0.5	1.6	0.2
Delta ambulatory time before/after self-admin	0.5	0.5	2.0	0.4	-0.5	-0.4	1.4	0.2
Time in closed arm before self-admin	0.7	0.8	1.5	-1.0	-0.7	-0.8	-0.6	-1.2
Time in closed arm after self-admin	2.2	2.3	4.2	0.2	-2.1	-1.9	1.2	-1.5
Time in open arm before self-admin	0.1	0.2	0.4	0.1	0.6	0.2	0.4	0.4
Time in open arm after self-admin	0.8	0.9	1.7	-1.2	0.5	1.0	-1.3	0.0
Sum of active levers in priming session hrs 5-6	0.5	0.4	1.5	1.2	0.7	0.2	-0.3	0.4
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.5	-0.6	-0.5	-0.2	-0.7
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.8	0.3	0.9	0.3	-0.8	0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.3	0.4	-0.1	0.4	-0.0	0.5
Time to tail flick, test, after self-admin	2.0	2.0	3.8	0.2	2.0	1.7	-1.5	1.1
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	2.4	0.1	1.6	1.0	-1.3	0.6
Delta time to tail flick, test, before/after SA	0.6	0.5	1.5	-0.1	1.2	0.7	-0.6	0.4
Ambulatory time before self-admin	1.2	1.3	2.6	-1.0	0.3	1.6	-1.5	0.8
Ambulatory time after self-admin	0.4	0.4	1.1	-0.0	0.1	1.1	0.1	1.0
Total heroin consumption	0.1	0.2	0.5	-0.4	-0.2	0.3	-0.7	-0.2
Area under the delay curve	0.6	0.7	2.2	1.5	-0.1	-0.3	0.8	0.6
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.3	-0.1	0.0	-0.2	0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.7	0.8	0.1	-0.3	0.2	0.1
Delay disc. indifference point, 2s delay	0.3	0.3	1.1	1.1	-0.4	-0.5	0.3	0.1
Delay disc. indifference point, 24s delay	1.0	1.0	2.2	-0.1	-0.7	-1.4	0.1	-1.5
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.2	-0.3	-0.2	0.0	-0.1
Delay disc. indifference point, 8s delay	1.0	1.1	2.5	1.2	0.8	0.8	0.5	1.6
Delay discount exponential model param	0.5	0.6	1.8	-1.3	0.2	0.3	-0.8	-0.6
Delay discount hyperbolic model param	0.5	0.5	1.8	-1.3	0.1	0.2	-0.7	-0.6
Fecal boli incidents, locomotor time 1	0.3	0.3	0.9	0.2	1.0	0.3	-0.7	0.0
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.3	0.1	0.5	0.3	0.7
Time >=10cm from walls, locomotor time 1	1.0	1.0	2.4	-0.1	-0.7	-1.5	0.4	-1.5
Bouts of movement, locomotor time 1	0.5	0.6	1.6	0.0	0.5	1.0	0.0	1.3
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.1	-0.3	0.3	0.4	0.5
Rest time, locomotor task time 1	0.2	0.2	0.6	0.1	-0.1	-0.6	0.8	-0.2
Distance moved, locomotor task time 1	0.5	0.5	1.9	-0.1	-0.2	0.7	-1.4	-0.0
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.5	-0.4	0.4	-0.4	-0.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	-0.1	-0.2	0.3	-0.1
Bouts of movement, locomotor time 2	1.5	1.6	3.3	0.3	-1.8	-1.4	1.3	-0.8
Total resting periods, locomotor time 2	0.7	0.8	1.6	0.4	-1.3	-1.0	0.9	-0.4
Rest time, locomotor task time 2	0.5	0.6	1.5	1.2	0.2	-0.1	1.0	0.7
Distance moved, locomotor task time 2	1.2	1.3	3.5	-1.9	-0.3	0.7	-1.5	-0.6
Vertical activity count, locomotor time 2	2.1	2.3	7.0	-2.6	-0.9	-0.4	-0.8	-1.7
Weight adjusted by age	0.3	0.3	0.7	-0.9	-0.0	-0.1	-0.7	-0.5
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	1.9	1.3	1.0	0.7	0.7	1.4
Locomotion in novel chamber	1.5	1.9	3.9	2.0	-0.3	-1.6	1.7	-0.3
Locomotion in novel chamber post-restriction	2.8	3.4	5.4	1.8	-1.6	-2.3	2.1	-1.2
Progressive ratio	0.7	0.8	3.2	1.8	-0.4	-0.7	0.4	0.1
Food seeking constrained by brief footshock	0.2	0.3	0.5	-0.3	0.6	0.7	-0.2	0.6
Seeking ratio, punishment vs. effort	0.6	0.8	2.6	-1.6	0.4	0.9	-0.4	0.3
Run reversals in cocaine runway, females	0.5	0.5	2.1	-0.1	1.4	0.2	0.0	0.5
Run reversals in cocaine runway, males	0.2	0.1	0.3	-0.5	-0.2	-0.2	0.6	-0.3
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.2	0.3	0.2	-0.5	0.0
Latency to leave start box in cocaine runway, F	0.4	0.4	0.9	-0.5	-0.3	-0.9	0.0	-0.9
Latency to leave start box in cocaine runway, M	1.6	1.5	2.9	0.4	1.1	1.7	-1.1	1.5
Cd content in liver	1.5	1.7	3.2	-1.8	1.6	1.2	-0.9	0.6
Co content in liver	0.6	0.7	1.7	0.1	1.2	0.5	-1.3	0.2
Cu content in liver	1.6	1.9	4.3	-1.2	0.8	1.7	-2.1	0.5
Fe content in liver	3.2	3.7	7.2	-2.6	-1.6	-1.4	-0.5	-2.7
K content in liver	0.1	0.1	0.1	-0.4	-0.3	0.0	-0.2	0.0
Mg content in liver	0.5	0.5	0.9	0.0	0.6	1.0	-0.6	0.9
Mn content in liver	0.4	0.5	1.0	-0.3	1.0	0.7	0.0	1.0
Na content in liver	0.3	0.4	1.0	1.0	-0.1	0.3	0.4	0.8
Rb content in liver	1.1	1.3	4.2	-2.0	-0.1	0.8	-1.4	-0.3
Se content in liver	1.1	1.4	3.2	-1.8	0.7	0.7	-1.6	-0.3
Sr content in liver	0.4	0.4	1.3	1.1	-0.4	0.1	0.4	0.5
Zn content in liver	0.3	0.3	0.6	0.7	0.4	0.7	-0.3	0.8