| # | tissue | modality | RNA phenotype | h2 | h2 se | h2 P | eQTL R2 | BLUP R2 | ENET R2 | LASSO R2 | eQTL P | BLUP P | ENET P | LASSO P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | gene expression | ENSRNOG00000000519 | 0.0220 | 0.0220 | 4.6e-03 | 0.007 | 0.012 | 0.001 | 0.008 | 5.3e-02 | 1.7e-02 | 0.24000 | 3.6e-02 |
| 2 | Brain | isoform ratio | ENSRNOT00000092400 | 0.0351 | 0.0326 | 6.5e-04 | 0.033 | 0.031 | 0.028 | 0.027 | 4.7e-04 | 6.6e-04 | 0.00120 | 1.5e-03 |
| 3 | Brain | isoform ratio | ENSRNOT00000092489 | 0.0464 | 0.0541 | 8.0e-04 | 0.024 | 0.021 | 0.020 | 0.017 | 2.5e-03 | 4.1e-03 | 0.00520 | 9.7e-03 |
| 4 | Liver | intron excision ratio | chr20:7061807:7062476 | 0.0519 | 0.0417 | 2.0e-06 | 0.042 | 0.034 | 0.034 | 0.035 | 1.9e-05 | 9.8e-05 | 0.00011 | 9.1e-05 |
| 5 | Liver | intron excision ratio | chr20:7061807:7067531 | 0.0398 | 0.0465 | 2.1e-03 | 0.016 | 0.016 | 0.008 | 0.015 | 6.3e-03 | 6.0e-03 | 0.04100 | 7.4e-03 |
| 6 | Liver | mRNA stability | ENSRNOG00000000519 | 0.0358 | 0.0309 | 5.2e-05 | 0.045 | 0.040 | 0.007 | 0.040 | 8.5e-06 | 2.8e-05 | 0.05500 | 3.0e-05 |
All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, the gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method.
| Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|
Trait | Avg chi2 ratio | Avg chi2 | Max chi2 | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|---|---|---|
| Body weight | 6.5 | 27.4 | 28.5 | 5.2 | -5.3 | 5.3 | -5.2 | 5.0 | 5.3 |
| Liver weight, left | 5.8 | 9.4 | 9.8 | 3.0 | -3.1 | 3.1 | -3.0 | 3.1 | 3.1 |
| Time >=10cm from walls, locomotor time 2 | 5.4 | 5.7 | 6.7 | 2.5 | -2.6 | 2.6 | -2.0 | 2.2 | 2.3 |
| Intermittent access day 15 total locomotion | 5.3 | 5.6 | 6.7 | 2.4 | -2.1 | 2.1 | -2.6 | 2.5 | 2.6 |
| Fe content in liver | 4.5 | 5.3 | 6.0 | 2.4 | -2.1 | 2.1 | -2.5 | 2.3 | 2.4 |
| Bone: final force | 4.1 | 6.8 | 7.2 | 2.7 | -2.6 | 2.6 | -2.6 | 2.6 | 2.6 |
| Right kidney weight | 4.0 | 11.5 | 11.8 | 3.4 | -3.4 | 3.4 | -3.4 | 3.3 | 3.4 |
| Progressive ratio | 3.9 | 4.5 | 5.3 | 2.0 | -2.0 | 2.0 | -2.3 | 2.3 | 2.0 |
| Condit. Reinf. lever presses | 3.6 | 4.9 | 5.6 | -2.3 | 2.1 | -2.1 | 2.2 | -2.3 | -2.4 |
| Locomotion distance, session 1 | 3.6 | 4.6 | 4.8 | -2.1 | 2.2 | -2.2 | 2.2 | -2.2 | -2.1 |
| Cu content in liver | 3.5 | 4.2 | 4.4 | -2.0 | 2.1 | -2.1 | 2.0 | -2.1 | -2.0 |
| Mg content in liver | 3.5 | 3.6 | 6.1 | -1.7 | 1.8 | -1.8 | 2.5 | -1.8 | -1.7 |
| Bone: final moment | 3.4 | 5.7 | 6.4 | 2.4 | -2.5 | 2.5 | -2.2 | 2.3 | 2.3 |
| Se content in liver | 3.4 | 4.1 | 5.2 | -1.9 | 2.1 | -2.1 | 2.3 | -1.9 | -1.8 |
| Left kidney weight | 3.3 | 9.4 | 11.8 | 3.0 | -3.0 | 3.0 | -3.4 | 2.9 | 3.1 |
| Bone: marrow area | 3.3 | 7.1 | 7.8 | 2.8 | -2.6 | 2.6 | -2.5 | 2.7 | 2.7 |
| Bone: endosteal estimation | 3.2 | 6.9 | 7.5 | 2.7 | -2.6 | 2.6 | -2.5 | 2.7 | 2.6 |
| Compulsive drug intake | 3.1 | 3.1 | 3.5 | -1.8 | 1.9 | -1.9 | 1.2 | -1.8 | -1.9 |
| Heart weight | 2.9 | 4.1 | 5.3 | -1.9 | 2.3 | -2.3 | 1.7 | -2.0 | -2.0 |
| Liver weight, right | 2.9 | 4.8 | 5.4 | 2.1 | -2.3 | 2.3 | -1.9 | 2.3 | 2.3 |
| Conditioned locomotion | 2.9 | 3.4 | 3.7 | 1.8 | -1.8 | 1.8 | -1.9 | 1.9 | 1.9 |
| Total zone transitions, hab. session 1 | 2.9 | 4.1 | 5.8 | -1.9 | 2.0 | -2.0 | 2.4 | -1.9 | -1.8 |
| Times rat made contact with spout | 2.8 | 3.2 | 3.4 | -1.8 | 1.8 | -1.8 | 1.7 | -1.8 | -1.7 |
| Length with tail | 2.7 | 10.0 | 13.6 | 3.1 | -2.9 | 2.9 | -3.7 | 3.0 | 3.2 |
| Tibia length | 2.7 | 7.7 | 8.8 | 2.8 | -2.5 | 2.5 | -2.9 | 2.9 | 3.0 |
| Locomotion velocity, hab. session 2 | 2.7 | 3.7 | 4.3 | -2.1 | 2.0 | -2.0 | 1.7 | -1.7 | -2.0 |
| Light reinforcement 2 | 2.6 | 3.5 | 3.7 | 1.9 | -1.8 | 1.8 | -1.9 | 1.9 | 1.9 |
| Delay disc. indifference point, 24s delay | 2.6 | 2.5 | 3.0 | 1.6 | -1.7 | 1.7 | -1.6 | 1.3 | 1.5 |
| Seeking ratio, punishment vs. effort | 2.5 | 3.1 | 3.7 | -1.7 | 1.7 | -1.7 | 1.7 | -1.9 | -1.7 |
| Total locomotion distance, hab. session 2 | 2.3 | 3.1 | 3.5 | -1.9 | 1.9 | -1.9 | 1.5 | -1.5 | -1.8 |
| Time to tail flick, vehicle, before self-admin | 2.3 | 2.3 | 3.5 | 1.5 | -1.6 | 1.6 | -0.6 | 1.9 | 1.6 |
| Length without tail | 2.2 | 4.8 | 5.5 | 2.1 | -2.3 | 2.3 | -2.3 | 1.9 | 2.1 |
| Parametrial fat weight | 2.2 | 4.2 | 5.5 | 2.0 | -2.0 | 2.0 | -1.9 | 2.3 | 2.0 |
| Distance moved, locomotor task time 2 | 2.2 | 2.5 | 3.4 | 1.7 | -1.5 | 1.5 | -1.4 | 1.5 | 1.8 |
| Co content in liver | 2.2 | 2.6 | 2.9 | 1.7 | -1.6 | 1.6 | -1.2 | 1.7 | 1.7 |
| Stereotopy head waving bouts, day 3 | 2.1 | 2.5 | 2.8 | 1.5 | -1.7 | 1.7 | -1.6 | 1.5 | 1.5 |
| Bone: trabecular spacing | 2.1 | 2.7 | 3.1 | 1.6 | -1.8 | 1.8 | -1.6 | 1.6 | 1.5 |
| Light reinforcement 1 | 2.0 | 3.6 | 4.4 | 1.9 | -1.9 | 1.9 | -1.7 | 2.1 | 1.9 |
| Intermittent access total locomotion | 2.0 | 2.3 | 3.1 | 1.5 | -1.3 | 1.3 | -1.8 | 1.5 | 1.6 |
| Total locomotion distance, hab. session 1 | 2.0 | 2.8 | 3.9 | -1.7 | 1.6 | -1.6 | 2.0 | -1.6 | -1.6 |
| Locomotion velocity, NPP test | 2.0 | 2.8 | 3.2 | -1.8 | 1.7 | -1.7 | 1.6 | -1.7 | -1.8 |
| Bone: periosteal estimation | 2.0 | 4.0 | 4.5 | 2.1 | -2.0 | 2.0 | -1.8 | 2.0 | 2.0 |
| Locomotion in novel chamber post-restriction | 2.0 | 2.4 | 2.7 | 1.6 | -1.6 | 1.6 | -1.5 | 1.5 | 1.5 |
| Locomotion velocity, hab. session 1 | 1.9 | 2.7 | 3.6 | -1.6 | 1.6 | -1.6 | 1.9 | -1.6 | -1.5 |
| BMI with tail | 1.8 | 5.9 | 7.4 | 2.5 | -2.7 | 2.7 | -1.9 | 2.3 | 2.4 |
| Total zone transitions, NPP test | 1.8 | 2.5 | 2.7 | -1.6 | 1.6 | -1.6 | 1.7 | -1.6 | -1.6 |
| Pavlov. Cond. lever latency | 1.7 | 2.4 | 3.2 | 1.6 | -1.3 | 1.3 | -1.4 | 1.7 | 1.8 |
| Bone: endosteal perimeter | 1.7 | 3.4 | 4.0 | 1.9 | -1.7 | 1.7 | -1.9 | 2.0 | 1.9 |
| Time in open arm after self-admin | 1.7 | 1.9 | 2.2 | -1.4 | 1.3 | -1.3 | 1.2 | -1.4 | -1.5 |
| Epididymis fat weight | 1.6 | 3.7 | 4.2 | 1.9 | -2.0 | 2.0 | -2.0 | 1.7 | 1.9 |
| Delta time in closed arm before/after self-admin | 1.6 | 1.5 | 2.0 | 1.2 | -1.2 | 1.2 | -1.4 | 1.2 | 1.2 |
| Delay disc. indifference point, 8s delay | 1.6 | 1.7 | 2.3 | 1.4 | -1.5 | 1.5 | -1.0 | 1.2 | 1.1 |
| Time >=10cm from walls, locomotor time 1 | 1.6 | 1.6 | 2.0 | 1.2 | -1.2 | 1.2 | -1.4 | 1.4 | 1.3 |
| Retroperitoneal fat weight | 1.5 | 4.8 | 5.5 | 2.1 | -2.3 | 2.3 | -2.3 | 2.1 | 2.1 |
| Water consumed over 24 hours | 1.5 | 1.8 | 2.0 | -1.3 | 1.4 | -1.4 | 1.2 | -1.3 | -1.3 |
| Intermittent access intake escalation | 1.5 | 1.5 | 1.8 | 1.2 | -1.0 | 1.0 | -1.3 | 1.3 | 1.4 |
| K content in liver | 1.5 | 1.5 | 1.9 | -1.1 | 1.4 | -1.4 | 1.3 | -1.1 | -1.0 |
| Intraocular pressure | 1.4 | 1.9 | 2.6 | 1.4 | -1.6 | 1.6 | -1.0 | 1.3 | 1.3 |
| Reaction time false alarm rate | 1.4 | 2.0 | 2.3 | -1.4 | 1.5 | -1.5 | 1.3 | -1.3 | -1.3 |
| Condit. Reinf. lever reinforcers received | 1.4 | 1.9 | 2.1 | -1.4 | 1.3 | -1.3 | 1.5 | -1.4 | -1.4 |
| Intermitt. access day 15 inactive lever presses | 1.4 | 1.5 | 1.9 | 1.2 | -1.0 | 1.0 | -1.4 | 1.4 | 1.4 |
| Bone: maximum force | 1.4 | 2.5 | 3.0 | 1.7 | -1.6 | 1.6 | -1.4 | 1.5 | 1.6 |
| Vertical activity count, locomotor time 2 | 1.4 | 1.5 | 2.2 | 1.3 | -1.0 | 1.0 | -1.4 | 1.0 | 1.5 |
| Tail length | 1.3 | 3.9 | 6.6 | 2.0 | -1.6 | 1.6 | -2.6 | 1.9 | 2.0 |
| Number of responses in last shaping day | 1.3 | 1.3 | 2.1 | -1.0 | 1.2 | -1.2 | 1.1 | -1.4 | -1.0 |
| Total locomotion distance, NPP test | 1.3 | 1.8 | 2.0 | -1.4 | 1.3 | -1.3 | 1.3 | -1.4 | -1.4 |
| Pavlov. Cond. response bias | 1.3 | 1.6 | 3.1 | -1.1 | 1.1 | -1.1 | 1.8 | -1.4 | -1.1 |
| Delta time to tail flick, vehicle, before/after SA | 1.3 | 1.3 | 2.2 | -1.1 | 1.0 | -1.0 | 0.6 | -1.5 | -1.3 |
| Delta time to tail flick, test, before/after SA | 1.3 | 1.1 | 1.6 | 1.3 | -1.2 | 1.2 | -0.6 | 1.0 | 1.1 |
| Stereotopy head waving duration, day 7 | 1.2 | 1.4 | 1.8 | 1.3 | -1.1 | 1.1 | -0.9 | 1.4 | 1.3 |
| Pavlov. Cond. magazine entry number | 1.2 | 1.5 | 2.7 | 1.1 | -1.0 | 1.0 | -1.6 | 1.2 | 1.2 |
| Cd content in liver | 1.2 | 1.3 | 1.5 | 1.2 | -1.1 | 1.1 | -1.2 | 1.0 | 1.2 |
| BMI without tail | 1.1 | 2.2 | 2.5 | 1.6 | -1.4 | 1.4 | -1.4 | 1.6 | 1.5 |
| Pavlov. Cond. change in total contacts | 1.1 | 1.5 | 2.0 | -1.3 | 1.1 | -1.1 | 1.1 | -1.4 | -1.4 |
| Pavlov. Cond. lever contacts | 1.1 | 1.6 | 2.1 | -1.3 | 1.0 | -1.0 | 1.3 | -1.4 | -1.5 |
| Time in novel zone, hab. session 2 | 1.1 | 1.1 | 1.9 | 1.4 | -1.0 | 1.0 | -0.6 | 0.9 | 1.3 |
| Bone: stiffness | 1.1 | 1.8 | 2.1 | 1.5 | -1.4 | 1.4 | -0.9 | 1.3 | 1.3 |
| Bone: trabecular number | 1.1 | 1.7 | 2.2 | -1.2 | 1.5 | -1.5 | 1.0 | -1.3 | -1.2 |
| Delay disc. indifference point, 4s delay | 1.1 | 1.1 | 1.7 | 1.1 | -1.3 | 1.3 | -0.8 | 1.0 | 0.7 |
| Delay discounting time to switch 0 sec | 1.0 | 1.5 | 1.6 | 1.3 | -1.3 | 1.3 | -1.1 | 1.2 | 1.3 |
| Locomotor testing rearing | 1.0 | 1.6 | 1.9 | 1.2 | -1.4 | 1.4 | -1.1 | 1.4 | 1.2 |
| Intermittent access standard deviation | 1.0 | 1.1 | 1.7 | 1.0 | -0.9 | 0.9 | -1.3 | 1.1 | 1.1 |
| Short access day 1 total infusions | 1.0 | 1.0 | 1.4 | -1.0 | 0.9 | -0.9 | 1.0 | -1.2 | -1.0 |
| Condit. Reinf. active minus inactive responses | 1.0 | 1.1 | 1.7 | -0.9 | 1.0 | -1.0 | 1.3 | -1.1 | -0.9 |
| Time in familiar zone, hab. session 2 | 1.0 | 1.0 | 1.6 | -1.3 | 1.0 | -1.0 | 0.5 | -0.9 | -1.2 |
| Bone: maximum moment | 1.0 | 1.8 | 2.1 | 1.5 | -1.5 | 1.5 | -1.1 | 1.2 | 1.3 |
| Bone: minimum diameter | 1.0 | 1.9 | 2.2 | 1.5 | -1.4 | 1.4 | -1.4 | 1.4 | 1.3 |
| Reaction time number correct | 0.9 | 1.4 | 1.8 | 1.0 | -1.3 | 1.3 | -1.3 | 1.1 | 0.9 |
| Reaction time trials correct on left | 0.9 | 1.4 | 1.8 | 1.0 | -1.3 | 1.3 | -1.3 | 1.1 | 0.9 |
| Reaction time trials on left | 0.9 | 1.3 | 1.7 | 0.9 | -1.3 | 1.3 | -1.3 | 1.1 | 0.8 |
| Reaction time trials completed | 0.9 | 1.3 | 1.7 | 0.9 | -1.3 | 1.3 | -1.3 | 1.1 | 0.8 |
| Reaction time trials AUC | 0.9 | 1.3 | 1.6 | 0.9 | -1.2 | 1.2 | -1.3 | 1.1 | 0.8 |
| Intermittent access intake day 1-15 change | 0.9 | 0.9 | 1.2 | 1.0 | -0.7 | 0.7 | -1.0 | 1.0 | 1.1 |
| Incentive Sensitization - Responses | 0.9 | 0.9 | 1.1 | -1.0 | 1.0 | -1.0 | 1.0 | -0.7 | -0.7 |
| Locomotion distance, session 2 | 0.9 | 1.3 | 1.5 | -1.1 | 1.2 | -1.2 | 1.0 | -1.2 | -1.1 |
| Locomotion distance, session 8 | 0.9 | 1.4 | 1.5 | -1.1 | 1.2 | -1.2 | 1.1 | -1.1 | -1.2 |
| Weight adjusted by age | 0.9 | 1.0 | 1.4 | 1.1 | -1.0 | 1.0 | -0.8 | 0.8 | 1.2 |
| Tibialis anterior weight | 0.8 | 2.9 | 3.4 | -1.8 | 1.5 | -1.5 | 1.8 | -1.7 | -1.7 |
| Delay discounting total patch changes 18 sec | 0.8 | 1.1 | 1.4 | 0.9 | -1.2 | 1.2 | -1.0 | 1.1 | 0.8 |
| Progressive ratio test 1 inactive lever presses | 0.8 | 0.9 | 1.0 | 1.0 | -0.9 | 0.9 | -1.0 | 1.0 | 1.0 |
| Distance traveled before self-admin | 0.8 | 0.9 | 1.5 | 0.9 | -0.9 | 0.9 | -0.9 | 1.2 | 0.9 |
| Delta time in open arm before/after self-admin | 0.8 | 0.7 | 1.0 | -0.8 | 0.7 | -0.7 | 1.0 | -1.0 | -1.0 |
| Diff in mean of infusions in LGA sessions | 0.8 | 0.9 | 1.1 | -1.0 | 1.0 | -1.0 | 0.8 | -1.0 | -0.9 |
| Area under the delay curve | 0.8 | 0.8 | 1.3 | 1.0 | -1.1 | 1.1 | -0.7 | 0.8 | 0.6 |
| Cocaine response after cond. not corrected | 0.7 | 0.7 | 1.0 | 0.8 | -1.0 | 1.0 | -0.8 | 0.8 | 0.7 |
| Saline control response | 0.7 | 0.9 | 1.0 | 0.9 | -1.0 | 1.0 | -0.9 | 0.9 | 0.9 |
| Pavlov. Cond. intertrial magazine entries | 0.7 | 1.0 | 1.4 | -0.8 | 1.2 | -1.2 | 1.1 | -0.6 | -0.7 |
| One hour access (0.3 mA shock) | 0.7 | 0.8 | 1.0 | -0.9 | 1.0 | -1.0 | 0.7 | -1.0 | -0.9 |
| Locomotion velocity, session 1 | 0.7 | 0.7 | 1.2 | -0.8 | 0.7 | -0.7 | 1.1 | -1.0 | -0.8 |
| Locomotion distance, session 7 | 0.7 | 0.9 | 1.4 | -0.9 | 0.8 | -0.8 | 0.9 | -1.2 | -1.0 |
| Pavlov. Cond. lever latency | 0.7 | 0.9 | 2.7 | 0.6 | -0.7 | 0.7 | -1.7 | 0.9 | 0.6 |
| Pavlov. Cond. magazine entry latency | 0.7 | 0.9 | 2.3 | -0.8 | 0.5 | -0.5 | 1.5 | -1.0 | -0.9 |
| Bone: periosteal perimeter | 0.7 | 1.2 | 1.4 | 1.1 | -1.1 | 1.1 | -1.1 | 1.2 | 1.0 |
| Delta ambulatory time before/after self-admin | 0.7 | 0.8 | 1.2 | -0.8 | 1.1 | -1.1 | 0.7 | -0.9 | -0.6 |
| Number of licking bursts | 0.6 | 0.8 | 1.0 | -0.8 | 1.0 | -1.0 | 1.0 | -0.7 | -0.7 |
| Mean time between licks in bursts | 0.6 | 0.9 | 1.4 | -0.9 | 1.2 | -1.2 | 0.8 | -0.7 | -0.7 |
| Cocaine response after cond. corrected | 0.6 | 0.7 | 0.9 | 0.8 | -1.0 | 1.0 | -0.8 | 0.8 | 0.7 |
| Condit. Reinf. active minus inactive responses | 0.6 | 0.8 | 0.9 | -0.9 | 1.0 | -1.0 | 0.7 | -0.9 | -0.8 |
| Condit. Reinf. active responses | 0.6 | 0.8 | 0.9 | -0.9 | 0.9 | -0.9 | 0.9 | -1.0 | -0.9 |
| Pavlov. Cond. response bias | 0.6 | 0.8 | 1.2 | -0.9 | 0.6 | -0.6 | 0.8 | -1.1 | -1.1 |
| Conditioned reinforcement - actives | 0.6 | 0.6 | 0.8 | 0.8 | -0.9 | 0.9 | -0.8 | 0.5 | 0.8 |
| Conditioned locomotion | 0.6 | 0.7 | 0.8 | 0.9 | -0.9 | 0.9 | -0.8 | 0.5 | 0.8 |
| Bone: apparent density | 0.6 | 0.9 | 1.3 | -0.9 | 1.2 | -1.2 | 0.7 | -1.0 | -0.8 |
| Bone: connectivity density | 0.6 | 0.9 | 1.7 | -0.8 | 1.3 | -1.3 | 0.5 | -0.9 | -0.7 |
| Sum of active levers in priming session hrs 5-6 | 0.6 | 0.6 | 1.0 | -0.6 | 1.0 | -1.0 | 0.5 | -0.9 | -0.6 |
| Delay discount exponential model param | 0.6 | 0.7 | 1.0 | -0.9 | 1.0 | -1.0 | 0.7 | -0.7 | -0.5 |
| Vertical activity count, locomotor time 1 | 0.6 | 0.6 | 0.9 | 0.8 | -0.8 | 0.8 | -0.5 | 0.8 | 1.0 |
| Zn content in liver | 0.6 | 0.6 | 1.2 | 0.8 | -1.1 | 1.1 | -0.4 | 0.5 | 0.5 |
| Reaction time num false alarms AUC | 0.5 | 0.7 | 0.9 | -1.0 | 0.9 | -0.9 | 0.7 | -0.6 | -0.8 |
| Reaction time mean AUC | 0.5 | 0.6 | 0.9 | 0.9 | -0.9 | 0.9 | -0.5 | 0.7 | 0.7 |
| Intermitt. access escalation Index | 0.5 | 0.5 | 0.7 | -0.7 | 0.7 | -0.7 | 0.8 | -0.5 | -0.7 |
| Locomotion velocity, session 2 | 0.5 | 0.6 | 1.5 | -0.6 | 0.7 | -0.7 | 1.2 | -0.5 | -0.5 |
| Stereotopy head waving bouts, day 7 | 0.5 | 0.5 | 0.7 | 0.8 | -0.7 | 0.7 | -0.5 | 0.8 | 0.7 |
| Pavlov. Cond. change in total contacts | 0.5 | 0.5 | 0.6 | 0.8 | -0.7 | 0.7 | 0.6 | 0.6 | 0.8 |
| Pavlov. Cond. lever contacts | 0.5 | 0.6 | 1.6 | -0.5 | 0.5 | -0.5 | 1.3 | -0.8 | -0.5 |
| Delta distance traveled before/after self-admin | 0.5 | 0.5 | 0.8 | -0.7 | 0.9 | -0.9 | 0.4 | -0.8 | -0.6 |
| Ambulatory time before self-admin | 0.5 | 0.5 | 0.9 | 0.6 | -0.6 | 0.6 | -0.8 | 0.9 | 0.7 |
| Total heroin consumption | 0.5 | 0.6 | 1.0 | -0.7 | 1.0 | -1.0 | 0.7 | -0.5 | -0.4 |
| Locomotion in novel chamber | 0.5 | 0.6 | 1.2 | -0.8 | 0.4 | -0.4 | 1.1 | -0.9 | -0.9 |
| Latency to leave start box in cocaine runway | 0.5 | 0.6 | 0.7 | -0.8 | 0.6 | -0.6 | 0.8 | -0.8 | -0.8 |
| Latency to leave start box in cocaine runway, F | 0.5 | 0.5 | 0.8 | -0.8 | 0.5 | -0.5 | 0.8 | -0.8 | -0.9 |
| Food consumed during 24 hour testing period | 0.4 | 0.5 | 0.7 | 0.7 | -0.7 | 0.7 | -0.8 | 0.7 | 0.7 |
| Incentive Sensitization - Breakpoint | 0.4 | 0.4 | 0.6 | -0.7 | 0.8 | -0.8 | 0.7 | -0.4 | -0.4 |
| Short access day 10 total locomotion | 0.4 | 0.5 | 0.7 | -0.8 | 0.8 | -0.8 | 0.3 | -0.5 | -0.7 |
| Context. condit. distance diff. score | 0.4 | 0.5 | 0.8 | -0.6 | 0.5 | -0.5 | 0.9 | -0.7 | -0.8 |
| Locomotion velocity, session 3 | 0.4 | 0.5 | 0.8 | 0.8 | -0.6 | 0.6 | -0.4 | 0.8 | 0.9 |
| Locomotion distance, session 3 | 0.4 | 0.4 | 1.2 | -0.5 | 0.6 | -0.6 | 1.1 | -0.5 | -0.5 |
| Incentive salience index mean | 0.4 | 0.5 | 1.0 | -0.5 | 0.6 | -0.6 | 1.0 | -0.7 | -0.5 |
| Total zone transitions, hab. session 2 | 0.4 | 0.5 | 0.7 | -0.7 | 0.8 | -0.8 | 0.6 | -0.5 | -0.7 |
| Pavlov. Cond. index score | 0.4 | 0.5 | 1.9 | -0.4 | 0.3 | -0.3 | 1.4 | -0.7 | -0.5 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.4 | 0.5 | 2.1 | -0.4 | 0.2 | -0.2 | 1.5 | -0.7 | -0.5 |
| Bone: trabecular thickness | 0.4 | 0.5 | 0.5 | 0.7 | -0.7 | 0.7 | -0.7 | 0.5 | 0.7 |
| Time in closed arm before self-admin | 0.4 | 0.4 | 0.6 | -0.7 | 0.8 | -0.8 | 0.5 | -0.7 | -0.5 |
| Delay discount hyperbolic model param | 0.4 | 0.4 | 0.7 | -0.7 | 0.8 | -0.8 | 0.4 | -0.5 | -0.3 |
| Indifference point 0 sec | 0.3 | 0.6 | 0.8 | 0.7 | -0.7 | 0.7 | -0.9 | 0.8 | 0.6 |
| Delay discounting total patch changes 0 sec | 0.3 | 0.5 | 0.7 | 0.6 | -0.7 | 0.7 | -0.8 | 0.7 | 0.6 |
| Delay discounting total patch changes 24 sec | 0.3 | 0.4 | 0.6 | -0.7 | 0.5 | -0.5 | 0.5 | -0.6 | -0.8 |
| Delay discounting water rate 18 sec | 0.3 | 0.4 | 0.6 | -0.8 | 0.7 | -0.7 | 0.1 | -0.7 | -0.7 |
| Condit. Reinf. active-inactive response ratio | 0.3 | 0.3 | 0.5 | -0.6 | 0.7 | -0.7 | 0.2 | -0.5 | -0.5 |
| Pavlov. Cond. magazine entry latency | 0.3 | 0.3 | 0.9 | 0.5 | -0.5 | 0.5 | -0.9 | 0.4 | 0.5 |
| Pavlov. Cond. index score | 0.3 | 0.4 | 0.7 | -0.7 | 0.5 | -0.5 | 0.5 | -0.8 | -0.8 |
| Intermittent access day 1 total infusions | 0.3 | 0.4 | 0.7 | -0.5 | 0.5 | -0.5 | 0.8 | -0.8 | -0.4 |
| Post-drug Anxiety | 0.3 | 0.4 | 0.6 | -0.5 | 0.8 | -0.8 | 0.5 | -0.4 | -0.4 |
| Baseline Anxiety | 0.3 | 0.3 | 0.4 | -0.6 | 0.5 | -0.5 | 0.5 | -0.6 | -0.6 |
| One hour access (shock baseline) | 0.3 | 0.4 | 0.6 | 0.6 | -0.5 | 0.5 | -0.6 | 0.5 | 0.8 |
| Time in novel zone, NPP test | 0.3 | 0.3 | 0.4 | 0.6 | -0.6 | 0.6 | -0.2 | 0.4 | 0.6 |
| Pavlov. Cond. latency score | 0.3 | 0.4 | 1.6 | -0.3 | 0.1 | -0.1 | 1.3 | -0.6 | -0.5 |
| Bone: maximum diameter | 0.3 | 0.5 | 0.7 | 0.8 | -0.7 | 0.7 | -0.8 | 0.7 | 0.7 |
| Breakpoint value in progressive ratio session | 0.3 | 0.3 | 0.4 | -0.6 | 0.7 | -0.7 | 0.5 | -0.5 | -0.5 |
| Extinction: sum of active levers before priming | 0.3 | 0.3 | 0.4 | -0.5 | 0.7 | -0.7 | 0.5 | -0.4 | -0.5 |
| Delay disc. indifference point, 16s delay | 0.3 | 0.3 | 0.4 | 0.5 | -0.6 | 0.6 | -0.6 | 0.3 | 0.5 |
| Extensor digitorum longus weight | 0.2 | 0.6 | 0.8 | -0.9 | 0.7 | -0.7 | 0.9 | -0.8 | -0.8 |
| Soleus weight | 0.2 | 0.6 | 0.7 | 0.8 | -0.8 | 0.8 | -0.5 | 0.8 | 0.8 |
| Delay discounting water rate 24 sec | 0.2 | 0.3 | 0.6 | -0.7 | 0.5 | -0.5 | 0.4 | -0.5 | -0.7 |
| Reaction time mean minus median | 0.2 | 0.2 | 0.3 | 0.5 | -0.4 | 0.4 | -0.4 | 0.5 | 0.5 |
| Reaction time mean minus median AUC | 0.2 | 0.2 | 0.3 | 0.5 | -0.6 | 0.6 | -0.3 | 0.3 | 0.3 |
| Reaction time mean | 0.2 | 0.2 | 0.3 | 0.6 | -0.6 | 0.6 | -0.2 | 0.4 | 0.4 |
| Median of all reaction times | 0.2 | 0.3 | 0.4 | 0.6 | -0.6 | 0.6 | -0.2 | 0.4 | 0.4 |
| Reaction time premature initiation rate | 0.2 | 0.3 | 0.7 | -0.5 | 0.6 | -0.6 | 0.8 | -0.4 | -0.4 |
| Social time | 0.2 | 0.2 | 0.4 | -0.5 | 0.4 | -0.4 | 0.7 | -0.2 | -0.5 |
| Pavlov. Cond. latency score | 0.2 | 0.2 | 0.4 | -0.5 | 0.4 | -0.4 | 0.3 | -0.6 | -0.6 |
| Intermittent access terminal intake (last 3 days) | 0.2 | 0.2 | 0.4 | 0.5 | -0.3 | 0.3 | -0.3 | 0.3 | 0.7 |
| Intermittent access day 1 locomotion | 0.2 | 0.2 | 0.3 | 0.4 | -0.4 | 0.4 | -0.5 | 0.4 | 0.5 |
| Progressive ratio test 2 inactive lever presses | 0.2 | 0.3 | 0.6 | -0.4 | 0.8 | -0.8 | 0.4 | -0.3 | -0.1 |
| Condit. Reinf. active responses | 0.2 | 0.2 | 0.5 | -0.4 | 0.4 | -0.4 | 0.7 | -0.6 | -0.3 |
| Time in novel zone, hab. session 1 | 0.2 | 0.2 | 0.3 | 0.5 | -0.4 | 0.4 | -0.3 | 0.5 | 0.6 |
| Novel to familiar place preference ratio | 0.2 | 0.2 | 0.4 | 0.6 | -0.6 | 0.6 | -0.1 | 0.4 | 0.5 |
| Novelty place preference | 0.2 | 0.2 | 0.3 | 0.5 | -0.6 | 0.6 | -0.2 | 0.3 | 0.5 |
| Bone: cortical area | 0.2 | 0.3 | 0.4 | 0.6 | -0.7 | 0.7 | -0.4 | 0.4 | 0.4 |
| Bone: cortical tissue density | 0.2 | 0.2 | 0.9 | 0.2 | -0.2 | 0.2 | -1.0 | 0.3 | 0.3 |
| Bone: post-yield work | 0.2 | 0.2 | 0.4 | 0.6 | -0.4 | 0.4 | -0.5 | 0.4 | 0.5 |
| Time in open arm before self-admin | 0.2 | 0.2 | 0.3 | -0.4 | 0.6 | -0.6 | 0.4 | -0.4 | -0.4 |
| Ambulatory time after self-admin | 0.2 | 0.2 | 0.4 | -0.4 | 0.7 | -0.7 | -0.1 | 0.0 | -0.1 |
| Delay disc. indifference point, 2s delay | 0.2 | 0.2 | 0.4 | -0.3 | 0.3 | -0.3 | 0.5 | -0.6 | -0.6 |
| Bouts of movement, locomotor time 1 | 0.2 | 0.2 | 0.3 | -0.5 | 0.5 | -0.5 | 0.4 | -0.3 | -0.6 |
| Bouts of movement, locomotor time 2 | 0.2 | 0.2 | 0.7 | 0.3 | -0.3 | 0.3 | -0.8 | 0.6 | 0.3 |
| Mn content in liver | 0.2 | 0.2 | 0.4 | -0.3 | 0.5 | -0.5 | 0.6 | -0.3 | -0.3 |
| Mean num. licks in bursts | 0.1 | 0.2 | 0.3 | -0.4 | 0.3 | -0.3 | 0.2 | -0.5 | -0.5 |
| Std. dev. time between licks in bursts | 0.1 | 0.1 | 0.1 | 0.3 | -0.3 | 0.3 | 0.1 | 0.4 | 0.2 |
| Indifference point function ln k | 0.1 | 0.2 | 0.3 | -0.4 | 0.3 | -0.3 | 0.6 | -0.4 | -0.4 |
| Indifference point function log k | 0.1 | 0.2 | 0.3 | -0.4 | 0.3 | -0.3 | 0.6 | -0.4 | -0.4 |
| Delay discounting total patch changes 6 sec | 0.1 | 0.1 | 0.2 | 0.2 | -0.2 | 0.2 | -0.4 | 0.3 | 0.1 |
| Delay discounting water rate 0 sec | 0.1 | 0.2 | 0.4 | -0.6 | 0.3 | -0.3 | 0.1 | -0.5 | -0.5 |
| Delay discounting water rate 12 sec | 0.1 | 0.1 | 0.2 | -0.5 | 0.3 | -0.3 | 0.3 | -0.4 | -0.4 |
| Delay discounting water rate 6 sec | 0.1 | 0.1 | 0.3 | -0.5 | 0.1 | -0.1 | 0.3 | -0.4 | -0.5 |
| Locomotor activity | 0.1 | 0.2 | 0.4 | 0.4 | -0.6 | 0.6 | -0.1 | 0.6 | 0.4 |
| Reaction time num false alarms | 0.1 | 0.1 | 0.1 | -0.4 | 0.3 | -0.3 | 0.2 | -0.1 | -0.3 |
| Reaction time premature initiations | 0.1 | 0.1 | 0.1 | 0.2 | -0.3 | 0.3 | -0.0 | 0.4 | 0.3 |
| Social responses | 0.1 | 0.1 | 0.2 | -0.4 | -0.0 | 0.0 | 0.2 | -0.1 | -0.5 |
| Pavlov. Cond. magazine entry number | 0.1 | 0.1 | 0.3 | -0.2 | 0.3 | -0.3 | 0.6 | -0.2 | -0.2 |
| Pavlov. Cond. lever-magazine prob. diff. | 0.1 | 0.2 | 0.3 | -0.5 | 0.3 | -0.3 | 0.2 | -0.6 | -0.6 |
| Conditioned reinforcement - inactives | 0.1 | 0.1 | 0.1 | -0.3 | 0.4 | -0.4 | 0.3 | -0.3 | -0.3 |
| Intermittent access intake escalation 2 | 0.1 | 0.1 | 0.2 | -0.0 | 0.5 | -0.5 | -0.2 | 0.0 | 0.1 |
| Intermitt. access day 1 inactive lever presses | 0.1 | 0.1 | 0.1 | -0.3 | 0.4 | -0.4 | 0.1 | -0.1 | -0.2 |
| Intermittent access day 15 total infusions | 0.1 | 0.1 | 0.2 | 0.4 | -0.2 | 0.2 | -0.3 | 0.2 | 0.5 |
| Short access day 1 total inactive lever presses | 0.1 | 0.1 | 0.2 | -0.2 | 0.5 | -0.5 | -0.1 | -0.3 | -0.2 |
| Short access day 1 locomotion | 0.1 | 0.1 | 0.1 | -0.3 | 0.1 | -0.1 | 0.3 | -0.2 | -0.3 |
| Stereotopy head waving duration, day 3 | 0.1 | 0.1 | 0.3 | 0.4 | -0.3 | 0.3 | -0.6 | 0.2 | 0.3 |
| Degree of sensitization distance | 0.1 | 0.1 | 0.3 | -0.1 | -0.1 | 0.1 | -0.5 | -0.2 | -0.1 |
| Condit. Reinf. active-inactive response ratio | 0.1 | 0.1 | 0.2 | -0.2 | 0.3 | -0.3 | 0.5 | -0.3 | -0.2 |
| Condit. Reinf. inactive responses | 0.1 | 0.1 | 0.2 | -0.4 | 0.4 | -0.4 | 0.2 | -0.4 | -0.3 |
| Condit. Reinf. lever presses | 0.1 | 0.1 | 0.4 | -0.2 | 0.3 | -0.3 | 0.6 | -0.3 | -0.2 |
| Bone: cortical apparent density | 0.1 | 0.2 | 0.8 | 0.1 | -0.2 | 0.2 | -0.9 | 0.2 | 0.2 |
| Bone: cortical thickness | 0.1 | 0.1 | 0.3 | -0.3 | 0.1 | -0.1 | 0.4 | -0.5 | -0.5 |
| Bone: trabecular tissue density | 0.1 | 0.2 | 0.5 | 0.3 | -0.3 | 0.3 | -0.7 | 0.2 | 0.3 |
| Distance traveled after self-admin | 0.1 | 0.1 | 0.4 | 0.2 | -0.0 | 0.0 | -0.5 | 0.6 | 0.5 |
| Active lever presses in extinction session 6 | 0.1 | 0.1 | 0.2 | 0.2 | -0.4 | 0.4 | -0.5 | -0.1 | 0.1 |
| Time in closed arm after self-admin | 0.1 | 0.1 | 0.1 | 0.2 | -0.2 | 0.2 | -0.3 | 0.1 | 0.4 |
| Time to tail flick, vehicle, after self-admin | 0.1 | 0.1 | 0.2 | -0.4 | 0.4 | -0.4 | 0.3 | -0.4 | -0.4 |
| Delay disc. indifference point, 0s delay | 0.1 | 0.1 | 0.3 | 0.3 | -0.5 | 0.5 | 0.1 | 0.0 | 0.1 |
| Change in fecal boli incidents, locomotor task | 0.1 | 0.1 | 0.3 | 0.2 | -0.4 | 0.4 | 0.5 | 0.3 | 0.1 |
| Rest time, locomotor task time 1 | 0.1 | 0.1 | 0.1 | 0.3 | -0.3 | 0.3 | -0.4 | 0.3 | 0.2 |
| Distance moved, locomotor task time 1 | 0.1 | 0.1 | 0.3 | 0.4 | -0.3 | 0.3 | -0.2 | 0.4 | 0.5 |
| Food seeking constrained by brief footshock | 0.1 | 0.1 | 0.1 | -0.3 | 0.2 | -0.2 | -0.3 | -0.3 | -0.2 |
| Run reversals in cocaine runway, females | 0.1 | 0.1 | 0.3 | 0.5 | -0.5 | 0.5 | -0.1 | 0.1 | 0.2 |
| Run reversals in cocaine runway, males | 0.1 | 0.1 | 0.3 | 0.5 | 0.1 | -0.1 | -0.2 | 0.5 | 0.5 |
| Na content in liver | 0.1 | 0.1 | 0.4 | -0.2 | 0.6 | -0.6 | -0.2 | 0.0 | 0.0 |
| Rb content in liver | 0.1 | 0.1 | 0.2 | 0.4 | -0.5 | 0.5 | -0.1 | 0.2 | 0.3 |
| Glucose | 0.0 | 0.0 | 0.1 | 0.0 | -0.2 | 0.2 | 0.3 | -0.2 | -0.1 |
| Indifference point AUC | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | -0.2 | 0.3 | -0.1 | -0.2 |
| Delay discounting total patch changes 12 sec | 0.0 | 0.0 | 0.1 | -0.1 | -0.1 | 0.1 | 0.3 | 0.1 | -0.2 |
| Locomotor testing distance | 0.0 | 0.1 | 0.3 | -0.1 | -0.2 | 0.2 | 0.6 | 0.1 | -0.1 |
| Reaction time omissions | 0.0 | 0.1 | 0.1 | 0.1 | -0.2 | 0.2 | -0.2 | 0.3 | 0.2 |
| Std. dev. reaction times | 0.0 | 0.0 | 0.1 | 0.2 | -0.2 | 0.2 | -0.3 | 0.1 | 0.2 |
| Social response proportion | 0.0 | 0.0 | 0.0 | -0.0 | -0.2 | 0.2 | -0.1 | -0.1 | -0.1 |
| Cocaine response before conditioning | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.1 | 0.1 |
| Condit. Reinf. inactive responses | 0.0 | 0.0 | 0.1 | 0.2 | -0.3 | 0.3 | -0.1 | 0.2 | 0.2 |
| Intermittent access total infusions | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | -0.2 | 0.2 | -0.4 | 0.0 |
| Cocaine induced anxiety | 0.0 | 0.1 | 0.1 | -0.2 | 0.4 | -0.4 | 0.1 | 0.0 | -0.1 |
| Lifetime Intake | 0.0 | 0.1 | 0.1 | 0.3 | -0.2 | 0.2 | -0.2 | -0.0 | 0.4 |
| Progressive ratio test 1 active lever presses | 0.0 | 0.0 | 0.1 | -0.1 | 0.0 | -0.0 | -0.0 | -0.3 | -0.1 |
| Progressive ratio test 1 breakpoint | 0.0 | 0.0 | 0.1 | -0.2 | 0.1 | -0.1 | 0.0 | -0.3 | -0.2 |
| Progressive ratio test 2 active lever presses | 0.0 | 0.0 | 0.1 | 0.0 | 0.0 | -0.0 | -0.1 | 0.0 | 0.2 |
| Progressive ratio test 2 breakpoint | 0.0 | 0.0 | 0.0 | -0.1 | 0.1 | -0.1 | 0.0 | -0.1 | 0.2 |
| Total sessions with >9 infusions | 0.0 | 0.0 | 0.1 | 0.1 | -0.3 | 0.3 | 0.0 | -0.1 | 0.1 |
| Short access day 10 total inactive lever presses | 0.0 | 0.0 | 0.2 | 0.0 | 0.1 | -0.1 | -0.1 | 0.5 | 0.1 |
| Short access day 10 total infusions | 0.0 | 0.0 | 0.1 | -0.1 | 0.2 | -0.2 | -0.3 | -0.1 | 0.1 |
| Short access total infusions | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.0 | -0.2 | 0.1 |
| Short access total locomotion | 0.0 | 0.0 | 0.1 | -0.0 | 0.1 | -0.1 | -0.4 | 0.1 | 0.1 |
| Locomotion velocity, session 7 | 0.0 | 0.0 | 0.1 | -0.0 | -0.1 | 0.1 | 0.0 | -0.2 | -0.1 |
| Locomotion velocity, session 8 | 0.0 | 0.0 | 0.0 | -0.0 | -0.1 | 0.1 | 0.2 | -0.1 | -0.1 |
| Degree of sensitization stereotypy | 0.0 | 0.0 | 0.1 | 0.1 | 0.0 | -0.0 | 0.4 | 0.2 | 0.1 |
| Time in familiar zone, hab. session 1 | 0.0 | 0.0 | 0.1 | -0.1 | -0.2 | 0.2 | 0.4 | -0.2 | -0.1 |
| Pavlov. Cond. intertrial magazine entries | 0.0 | 0.0 | 0.1 | -0.0 | 0.2 | -0.2 | -0.3 | -0.1 | 0.1 |
| Bone surface | 0.0 | 0.0 | 0.1 | 0.0 | 0.3 | -0.3 | -0.1 | -0.1 | 0.1 |
| Bone volume | 0.0 | 0.0 | 0.1 | 0.2 | -0.0 | 0.0 | -0.2 | 0.1 | 0.2 |
| Bone: cortical porosity | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.2 | 0.0 |
| Bone: cortical porosity | 0.0 | 0.0 | 0.1 | -0.0 | 0.0 | -0.0 | 0.0 | -0.3 | -0.1 |
| Bone: cortical thickness | 0.0 | 0.0 | 0.1 | 0.1 | -0.3 | 0.3 | 0.0 | 0.1 | 0.1 |
| Bone: elastic displacement | 0.0 | 0.0 | 0.1 | -0.1 | 0.3 | -0.3 | 0.1 | -0.3 | -0.2 |
| Bone: elastic work | 0.0 | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | -0.1 | -0.1 | 0.0 |
| Bone: tissue strength | 0.0 | 0.0 | 0.1 | -0.0 | -0.1 | 0.1 | -0.4 | -0.1 | -0.1 |
| Time to tail flick, test, before self-admin | 0.0 | 0.0 | 0.1 | -0.3 | 0.2 | -0.2 | -0.1 | 0.1 | -0.2 |
| Time to tail flick, test, after self-admin | 0.0 | 0.0 | 0.0 | 0.1 | 0.0 | -0.0 | 0.1 | 0.1 | 0.2 |
| Fecal boli incidents, locomotor time 1 | 0.0 | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | 0.1 | -0.1 | -0.1 |
| Total resting periods, locomotor time 1 | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | -0.2 | 0.1 | -0.0 | -0.3 |
| Total resting periods, locomotor time 2 | 0.0 | 0.0 | 0.1 | -0.2 | 0.2 | -0.2 | -0.3 | 0.1 | -0.2 |
| Rest time, locomotor task time 2 | 0.0 | 0.0 | 0.1 | -0.1 | 0.0 | -0.0 | -0.2 | 0.2 | -0.3 |
| Seeking ratio, delayed vs. immediate footshock | 0.0 | 0.1 | 0.2 | 0.0 | -0.0 | 0.0 | -0.4 | 0.4 | 0.1 |
| Latency to leave start box in cocaine runway, M | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.3 | -0.1 | 0.1 |
| Sr content in liver | 0.0 | 0.0 | 0.1 | -0.1 | 0.1 | -0.1 | 0.0 | -0.3 | -0.2 |
For each tested trait, stats based on TWAS chi2 (squared Z-score) for the above models are shown. Avg chi2 ratio is the mean chi2 across all models for this gene, divided by the mean chi2 across all models for all genes. Avg chi2 is the mean chi2 across all models for this gene. Max chi2 is the highest chi2 across all models for this gene.
The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.