Stk38

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	ENSRNOG00000000519	0.02	0.02	4.6e-03	0.01	0.01	0	0.01	5.3e-02	1.7e-02	2.4e-01	3.6e-02
2	Brain	isoform ratio	ENSRNOT00000092400	0.04	0.03	6.5e-04	0.03	0.03	0.03	0.03	4.7e-04	6.6e-04	1.2e-03	1.5e-03
3	Brain	isoform ratio	ENSRNOT00000092489	0.05	0.05	8.0e-04	0.02	0.02	0.02	0.02	2.5e-03	4.1e-03	5.2e-03	9.7e-03
4	Liver	intron excision ratio	chr20:7061807:7062476	0.05	0.04	2.0e-06	0.04	0.03	0.03	0.04	1.9e-05	9.8e-05	1.1e-04	9.1e-05
5	Liver	intron excision ratio	chr20:7061807:7067531	0.04	0.05	2.1e-03	0.02	0.02	0.01	0.01	6.3e-03	6.0e-03	4.1e-02	7.4e-03
6	Liver	mRNA stability	ENSRNOG00000000519	0.04	0.03	5.2e-05	0.04	0.04	0.01	0.04	8.5e-06	2.8e-05	5.5e-02	3.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
BMI with tail	1.8	5.9	7.4	2.5	-2.7	2.7	-1.9	2.3	2.4
BMI without tail	1.1	2.2	2.5	1.6	-1.4	1.4	-1.4	1.6	1.5
Body weight	6.5	27.4	28.5	5.2	-5.3	5.3	-5.2	5.0	5.3
Epididymis fat weight	1.6	3.7	4.2	1.9	-2.0	2.0	-2.0	1.7	1.9
Glucose	0.0	0.0	0.1	0.0	-0.2	0.2	0.3	-0.2	-0.1
Heart weight	2.9	4.1	5.3	-1.9	2.3	-2.3	1.7	-2.0	-2.0
Left kidney weight	3.3	9.4	11.8	3.0	-3.0	3.0	-3.4	2.9	3.1
Right kidney weight	4.0	11.5	11.8	3.4	-3.4	3.4	-3.4	3.3	3.4
Tail length	1.3	3.9	6.6	2.0	-1.6	1.6	-2.6	1.9	2.0
Length with tail	2.7	10.0	13.6	3.1	-2.9	2.9	-3.7	3.0	3.2
Length without tail	2.2	4.8	5.5	2.1	-2.3	2.3	-2.3	1.9	2.1
Liver weight, left	5.8	9.4	9.8	3.0	-3.1	3.1	-3.0	3.1	3.1
Liver weight, right	2.9	4.8	5.4	2.1	-2.3	2.3	-1.9	2.3	2.3
Parametrial fat weight	2.2	4.2	5.5	2.0	-2.0	2.0	-1.9	2.3	2.0
Retroperitoneal fat weight	1.5	4.8	5.5	2.1	-2.3	2.3	-2.3	2.1	2.1
Intraocular pressure	1.4	1.9	2.6	1.4	-1.6	1.6	-1.0	1.3	1.3
Extensor digitorum longus weight	0.2	0.6	0.8	-0.9	0.7	-0.7	0.9	-0.8	-0.8
Soleus weight	0.2	0.6	0.7	0.8	-0.8	0.8	-0.5	0.8	0.8
Tibialis anterior weight	0.8	2.9	3.4	-1.8	1.5	-1.5	1.8	-1.7	-1.7
Tibia length	2.7	7.7	8.8	2.8	-2.5	2.5	-2.9	2.9	3.0
Number of licking bursts	0.6	0.8	1.0	-0.8	1.0	-1.0	1.0	-0.7	-0.7
Food consumed during 24 hour testing period	0.4	0.5	0.7	0.7	-0.7	0.7	-0.8	0.7	0.7
Times rat made contact with spout	2.8	3.2	3.4	-1.8	1.8	-1.8	1.7	-1.8	-1.7
Mean time between licks in bursts	0.6	0.9	1.4	-0.9	1.2	-1.2	0.8	-0.7	-0.7
Mean num. licks in bursts	0.1	0.2	0.3	-0.4	0.3	-0.3	0.2	-0.5	-0.5
Std. dev. time between licks in bursts	0.1	0.1	0.1	0.3	-0.3	0.3	0.1	0.4	0.2
Water consumed over 24 hours	1.5	1.8	2.0	-1.3	1.4	-1.4	1.2	-1.3	-1.3
Indifference point 0 sec	0.3	0.6	0.8	0.7	-0.7	0.7	-0.9	0.8	0.6
Indifference point AUC	0.0	0.0	0.1	-0.2	0.2	-0.2	0.3	-0.1	-0.2
Indifference point function ln k	0.1	0.2	0.3	-0.4	0.3	-0.3	0.6	-0.4	-0.4
Indifference point function log k	0.1	0.2	0.3	-0.4	0.3	-0.3	0.6	-0.4	-0.4
Delay discounting total patch changes 0 sec	0.3	0.5	0.7	0.6	-0.7	0.7	-0.8	0.7	0.6
Delay discounting total patch changes 12 sec	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3	0.1	-0.2
Delay discounting total patch changes 18 sec	0.8	1.1	1.4	0.9	-1.2	1.2	-1.0	1.1	0.8
Delay discounting total patch changes 24 sec	0.3	0.4	0.6	-0.7	0.5	-0.5	0.5	-0.6	-0.8
Delay discounting total patch changes 6 sec	0.1	0.1	0.2	0.2	-0.2	0.2	-0.4	0.3	0.1
Delay discounting time to switch 0 sec	1.0	1.5	1.6	1.3	-1.3	1.3	-1.1	1.2	1.3
Delay discounting water rate 0 sec	0.1	0.2	0.4	-0.6	0.3	-0.3	0.1	-0.5	-0.5
Delay discounting water rate 12 sec	0.1	0.1	0.2	-0.5	0.3	-0.3	0.3	-0.4	-0.4
Delay discounting water rate 18 sec	0.3	0.4	0.6	-0.8	0.7	-0.7	0.1	-0.7	-0.7
Delay discounting water rate 24 sec	0.2	0.3	0.6	-0.7	0.5	-0.5	0.4	-0.5	-0.7
Delay discounting water rate 6 sec	0.1	0.1	0.3	-0.5	0.1	-0.1	0.3	-0.4	-0.5
Locomotor activity	0.1	0.2	0.4	0.4	-0.6	0.6	-0.1	0.6	0.4
Locomotor testing distance	0.0	0.1	0.3	-0.1	-0.2	0.2	0.6	0.1	-0.1
Locomotor testing rearing	1.0	1.6	1.9	1.2	-1.4	1.4	-1.1	1.4	1.2
Light reinforcement 1	2.0	3.6	4.4	1.9	-1.9	1.9	-1.7	2.1	1.9
Light reinforcement 2	2.6	3.5	3.7	1.9	-1.8	1.8	-1.9	1.9	1.9
Reaction time number correct	0.9	1.4	1.8	1.0	-1.3	1.3	-1.3	1.1	0.9
Reaction time mean minus median	0.2	0.2	0.3	0.5	-0.4	0.4	-0.4	0.5	0.5
Reaction time mean minus median AUC	0.2	0.2	0.3	0.5	-0.6	0.6	-0.3	0.3	0.3
Reaction time num false alarms	0.1	0.1	0.1	-0.4	0.3	-0.3	0.2	-0.1	-0.3
Reaction time num false alarms AUC	0.5	0.7	0.9	-1.0	0.9	-0.9	0.7	-0.6	-0.8
Reaction time trials correct on left	0.9	1.4	1.8	1.0	-1.3	1.3	-1.3	1.1	0.9
Reaction time trials on left	0.9	1.3	1.7	0.9	-1.3	1.3	-1.3	1.1	0.8
Reaction time mean	0.2	0.2	0.3	0.6	-0.6	0.6	-0.2	0.4	0.4
Reaction time mean AUC	0.5	0.6	0.9	0.9	-0.9	0.9	-0.5	0.7	0.7
Median of all reaction times	0.2	0.3	0.4	0.6	-0.6	0.6	-0.2	0.4	0.4
Reaction time omissions	0.0	0.1	0.1	0.1	-0.2	0.2	-0.2	0.3	0.2
Reaction time false alarm rate	1.4	2.0	2.3	-1.4	1.5	-1.5	1.3	-1.3	-1.3
Reaction time premature initiation rate	0.2	0.3	0.7	-0.5	0.6	-0.6	0.8	-0.4	-0.4
Reaction time premature initiations	0.1	0.1	0.1	0.2	-0.3	0.3	-0.0	0.4	0.3
Std. dev. reaction times	0.0	0.0	0.1	0.2	-0.2	0.2	-0.3	0.1	0.2
Reaction time trials completed	0.9	1.3	1.7	0.9	-1.3	1.3	-1.3	1.1	0.8
Reaction time trials AUC	0.9	1.3	1.6	0.9	-1.2	1.2	-1.3	1.1	0.8
Social response proportion	0.0	0.0	0.0	-0.0	-0.2	0.2	-0.1	-0.1	-0.1
Social responses	0.1	0.1	0.2	-0.4	-0.0	0.0	0.2	-0.1	-0.5
Social time	0.2	0.2	0.4	-0.5	0.4	-0.4	0.7	-0.2	-0.5
Conditioned locomotion	2.9	3.4	3.7	1.8	-1.8	1.8	-1.9	1.9	1.9
Cocaine response after cond. corrected	0.6	0.7	0.9	0.8	-1.0	1.0	-0.8	0.8	0.7
Cocaine response after cond. not corrected	0.7	0.7	1.0	0.8	-1.0	1.0	-0.8	0.8	0.7
Cocaine response before conditioning	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	0.1
Saline control response	0.7	0.9	1.0	0.9	-1.0	1.0	-0.9	0.9	0.9
Condit. Reinf. active minus inactive responses	0.6	0.8	0.9	-0.9	1.0	-1.0	0.7	-0.9	-0.8
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	-0.6	0.7	-0.7	0.2	-0.5	-0.5
Condit. Reinf. active responses	0.6	0.8	0.9	-0.9	0.9	-0.9	0.9	-1.0	-0.9
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.2	-0.3	0.3	-0.1	0.2	0.2
Condit. Reinf. lever presses	3.6	4.9	5.6	-2.3	2.1	-2.1	2.2	-2.3	-2.4
Condit. Reinf. lever reinforcers received	1.4	1.9	2.1	-1.4	1.3	-1.3	1.5	-1.4	-1.4
Pavlov. Cond. lever latency	1.7	2.4	3.2	1.6	-1.3	1.3	-1.4	1.7	1.8
Pavlov. Cond. magazine entry latency	0.3	0.3	0.9	0.5	-0.5	0.5	-0.9	0.4	0.5
Pavlov. Cond. change in total contacts	1.1	1.5	2.0	-1.3	1.1	-1.1	1.1	-1.4	-1.4
Pavlov. Cond. index score	0.3	0.4	0.7	-0.7	0.5	-0.5	0.5	-0.8	-0.8
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.5	0.4	-0.4	0.3	-0.6	-0.6
Pavlov. Cond. lever contacts	1.1	1.6	2.1	-1.3	1.0	-1.0	1.3	-1.4	-1.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.2	0.3	-0.3	0.6	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.4	-0.8	1.2	-1.2	1.1	-0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.5	0.3	-0.3	0.2	-0.6	-0.6
Pavlov. Cond. response bias	0.6	0.8	1.2	-0.9	0.6	-0.6	0.8	-1.1	-1.1
Conditioned reinforcement - actives	0.6	0.6	0.8	0.8	-0.9	0.9	-0.8	0.5	0.8
Conditioned reinforcement - inactives	0.1	0.1	0.1	-0.3	0.4	-0.4	0.3	-0.3	-0.3
Conditioned locomotion	0.6	0.7	0.8	0.9	-0.9	0.9	-0.8	0.5	0.8
Intermittent access intake day 1-15 change	0.9	0.9	1.2	1.0	-0.7	0.7	-1.0	1.0	1.1
Intermittent access intake escalation	1.5	1.5	1.8	1.2	-1.0	1.0	-1.3	1.3	1.4
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.0	0.5	-0.5	-0.2	0.0	0.1
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	-0.3	0.4	-0.4	0.1	-0.1	-0.2
Intermitt. access day 15 inactive lever presses	1.4	1.5	1.9	1.2	-1.0	1.0	-1.4	1.4	1.4
Intermitt. access escalation Index	0.5	0.5	0.7	-0.7	0.7	-0.7	0.8	-0.5	-0.7
Intermittent access day 1 total infusions	0.3	0.4	0.7	-0.5	0.5	-0.5	0.8	-0.8	-0.4
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.4	-0.2	0.2	-0.3	0.2	0.5
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.4	0.5	-0.3	0.3	-0.3	0.3	0.7
Intermittent access total infusions	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	-0.4	0.0
Intermittent access day 1 locomotion	0.2	0.2	0.3	0.4	-0.4	0.4	-0.5	0.4	0.5
Intermittent access day 15 total locomotion	5.3	5.6	6.7	2.4	-2.1	2.1	-2.6	2.5	2.6
Intermittent access total locomotion	2.0	2.3	3.1	1.5	-1.3	1.3	-1.8	1.5	1.6
Intermittent access standard deviation	1.0	1.1	1.7	1.0	-0.9	0.9	-1.3	1.1	1.1
Cocaine induced anxiety	0.0	0.1	0.1	-0.2	0.4	-0.4	0.1	0.0	-0.1
Post-drug Anxiety	0.3	0.4	0.6	-0.5	0.8	-0.8	0.5	-0.4	-0.4
Baseline Anxiety	0.3	0.3	0.4	-0.6	0.5	-0.5	0.5	-0.6	-0.6
Lifetime Intake	0.0	0.1	0.1	0.3	-0.2	0.2	-0.2	-0.0	0.4
Incentive Sensitization - Responses	0.9	0.9	1.1	-1.0	1.0	-1.0	1.0	-0.7	-0.7
Incentive Sensitization - Breakpoint	0.4	0.4	0.6	-0.7	0.8	-0.8	0.7	-0.4	-0.4
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.1	0.0	-0.0	-0.0	-0.3	-0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.2	0.1	-0.1	0.0	-0.3	-0.2
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.0	1.0	-0.9	0.9	-1.0	1.0	1.0
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.0	0.0	-0.0	-0.1	0.0	0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0	-0.1	0.2
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.6	-0.4	0.8	-0.8	0.4	-0.3	-0.1
Total sessions with >9 infusions	0.0	0.0	0.1	0.1	-0.3	0.3	0.0	-0.1	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.2	0.5	-0.5	-0.1	-0.3	-0.2
Short access day 10 total inactive lever presses	0.0	0.0	0.2	0.0	0.1	-0.1	-0.1	0.5	0.1
Short access day 1 total infusions	1.0	1.0	1.4	-1.0	0.9	-0.9	1.0	-1.2	-1.0
Short access day 10 total infusions	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.3	-0.1	0.1
Short access total infusions	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.2	0.1
Short access day 1 locomotion	0.1	0.1	0.1	-0.3	0.1	-0.1	0.3	-0.2	-0.3
Short access day 10 total locomotion	0.4	0.5	0.7	-0.8	0.8	-0.8	0.3	-0.5	-0.7
Short access total locomotion	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.4	0.1	0.1
Compulsive drug intake	3.1	3.1	3.5	-1.8	1.9	-1.9	1.2	-1.8	-1.9
One hour access (0.3 mA shock)	0.7	0.8	1.0	-0.9	1.0	-1.0	0.7	-1.0	-0.9
One hour access (shock baseline)	0.3	0.4	0.6	0.6	-0.5	0.5	-0.6	0.5	0.8
Number of responses in last shaping day	1.3	1.3	2.1	-1.0	1.2	-1.2	1.1	-1.4	-1.0
Context. condit. distance diff. score	0.4	0.5	0.8	-0.6	0.5	-0.5	0.9	-0.7	-0.8
Locomotion velocity, session 1	0.7	0.7	1.2	-0.8	0.7	-0.7	1.1	-1.0	-0.8
Locomotion distance, session 1	3.6	4.6	4.8	-2.1	2.2	-2.2	2.2	-2.2	-2.1
Locomotion velocity, session 2	0.5	0.6	1.5	-0.6	0.7	-0.7	1.2	-0.5	-0.5
Locomotion distance, session 2	0.9	1.3	1.5	-1.1	1.2	-1.2	1.0	-1.2	-1.1
Locomotion velocity, session 3	0.4	0.5	0.8	0.8	-0.6	0.6	-0.4	0.8	0.9
Locomotion distance, session 3	0.4	0.4	1.2	-0.5	0.6	-0.6	1.1	-0.5	-0.5
Stereotopy head waving bouts, day 3	2.1	2.5	2.8	1.5	-1.7	1.7	-1.6	1.5	1.5
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.4	-0.3	0.3	-0.6	0.2	0.3
Locomotion velocity, session 7	0.0	0.0	0.1	-0.0	-0.1	0.1	0.0	-0.2	-0.1
Locomotion distance, session 7	0.7	0.9	1.4	-0.9	0.8	-0.8	0.9	-1.2	-1.0
Stereotopy head waving bouts, day 7	0.5	0.5	0.7	0.8	-0.7	0.7	-0.5	0.8	0.7
Stereotopy head waving duration, day 7	1.2	1.4	1.8	1.3	-1.1	1.1	-0.9	1.4	1.3
Locomotion velocity, session 8	0.0	0.0	0.0	-0.0	-0.1	0.1	0.2	-0.1	-0.1
Locomotion distance, session 8	0.9	1.4	1.5	-1.1	1.2	-1.2	1.1	-1.1	-1.2
Degree of sensitization distance	0.1	0.1	0.3	-0.1	-0.1	0.1	-0.5	-0.2	-0.1
Degree of sensitization stereotypy	0.0	0.0	0.1	0.1	0.0	-0.0	0.4	0.2	0.1
Condit. Reinf. active minus inactive responses	1.0	1.1	1.7	-0.9	1.0	-1.0	1.3	-1.1	-0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	0.3	-0.3	0.5	-0.3	-0.2
Condit. Reinf. active responses	0.2	0.2	0.5	-0.4	0.4	-0.4	0.7	-0.6	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.4	-0.4	0.2	-0.4	-0.3
Incentive salience index mean	0.4	0.5	1.0	-0.5	0.6	-0.6	1.0	-0.7	-0.5
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.2	0.3	-0.3	0.6	-0.3	-0.2
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	-0.2	0.2	0.4	-0.2	-0.1
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.5	-0.4	0.4	-0.3	0.5	0.6
Total zone transitions, hab. session 1	2.9	4.1	5.8	-1.9	2.0	-2.0	2.4	-1.9	-1.8
Total locomotion distance, hab. session 1	2.0	2.8	3.9	-1.7	1.6	-1.6	2.0	-1.6	-1.6
Locomotion velocity, hab. session 1	1.9	2.7	3.6	-1.6	1.6	-1.6	1.9	-1.6	-1.5
Time in familiar zone, hab. session 2	1.0	1.0	1.6	-1.3	1.0	-1.0	0.5	-0.9	-1.2
Time in novel zone, hab. session 2	1.1	1.1	1.9	1.4	-1.0	1.0	-0.6	0.9	1.3
Total zone transitions, hab. session 2	0.4	0.5	0.7	-0.7	0.8	-0.8	0.6	-0.5	-0.7
Total locomotion distance, hab. session 2	2.3	3.1	3.5	-1.9	1.9	-1.9	1.5	-1.5	-1.8
Locomotion velocity, hab. session 2	2.7	3.7	4.3	-2.1	2.0	-2.0	1.7	-1.7	-2.0
Novel to familiar place preference ratio	0.2	0.2	0.4	0.6	-0.6	0.6	-0.1	0.4	0.5
Novelty place preference	0.2	0.2	0.3	0.5	-0.6	0.6	-0.2	0.3	0.5
Time in novel zone, NPP test	0.3	0.3	0.4	0.6	-0.6	0.6	-0.2	0.4	0.6
Total zone transitions, NPP test	1.8	2.5	2.7	-1.6	1.6	-1.6	1.7	-1.6	-1.6
Total locomotion distance, NPP test	1.3	1.8	2.0	-1.4	1.3	-1.3	1.3	-1.4	-1.4
Locomotion velocity, NPP test	2.0	2.8	3.2	-1.8	1.7	-1.7	1.6	-1.7	-1.8
Pavlov. Cond. lever latency	0.7	0.9	2.7	0.6	-0.7	0.7	-1.7	0.9	0.6
Pavlov. Cond. magazine entry latency	0.7	0.9	2.3	-0.8	0.5	-0.5	1.5	-1.0	-0.9
Pavlov. Cond. change in total contacts	0.5	0.5	0.6	0.8	-0.7	0.7	0.6	0.6	0.8
Pavlov. Cond. index score	0.4	0.5	1.9	-0.4	0.3	-0.3	1.4	-0.7	-0.5
Pavlov. Cond. latency score	0.3	0.4	1.6	-0.3	0.1	-0.1	1.3	-0.6	-0.5
Pavlov. Cond. lever contacts	0.5	0.6	1.6	-0.5	0.5	-0.5	1.3	-0.8	-0.5
Pavlov. Cond. magazine entry number	1.2	1.5	2.7	1.1	-1.0	1.0	-1.6	1.2	1.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.0	0.2	-0.2	-0.3	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	2.1	-0.4	0.2	-0.2	1.5	-0.7	-0.5
Pavlov. Cond. response bias	1.3	1.6	3.1	-1.1	1.1	-1.1	1.8	-1.4	-1.1
Bone: apparent density	0.6	0.9	1.3	-0.9	1.2	-1.2	0.7	-1.0	-0.8
Bone surface	0.0	0.0	0.1	0.0	0.3	-0.3	-0.1	-0.1	0.1
Bone volume	0.0	0.0	0.1	0.2	-0.0	0.0	-0.2	0.1	0.2
Bone: connectivity density	0.6	0.9	1.7	-0.8	1.3	-1.3	0.5	-0.9	-0.7
Bone: cortical apparent density	0.1	0.2	0.8	0.1	-0.2	0.2	-0.9	0.2	0.2
Bone: cortical area	0.2	0.3	0.4	0.6	-0.7	0.7	-0.4	0.4	0.4
Bone: cortical porosity	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	-0.2	0.0
Bone: cortical porosity	0.0	0.0	0.1	-0.0	0.0	-0.0	0.0	-0.3	-0.1
Bone: cortical thickness	0.1	0.1	0.3	-0.3	0.1	-0.1	0.4	-0.5	-0.5
Bone: cortical thickness	0.0	0.0	0.1	0.1	-0.3	0.3	0.0	0.1	0.1
Bone: cortical tissue density	0.2	0.2	0.9	0.2	-0.2	0.2	-1.0	0.3	0.3
Bone: elastic displacement	0.0	0.0	0.1	-0.1	0.3	-0.3	0.1	-0.3	-0.2
Bone: elastic work	0.0	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.1	0.0
Bone: endosteal estimation	3.2	6.9	7.5	2.7	-2.6	2.6	-2.5	2.7	2.6
Bone: endosteal perimeter	1.7	3.4	4.0	1.9	-1.7	1.7	-1.9	2.0	1.9
Bone: final force	4.1	6.8	7.2	2.7	-2.6	2.6	-2.6	2.6	2.6
Bone: final moment	3.4	5.7	6.4	2.4	-2.5	2.5	-2.2	2.3	2.3
Bone: marrow area	3.3	7.1	7.8	2.8	-2.6	2.6	-2.5	2.7	2.7
Bone: maximum diameter	0.3	0.5	0.7	0.8	-0.7	0.7	-0.8	0.7	0.7
Bone: maximum force	1.4	2.5	3.0	1.7	-1.6	1.6	-1.4	1.5	1.6
Bone: maximum moment	1.0	1.8	2.1	1.5	-1.5	1.5	-1.1	1.2	1.3
Bone: minimum diameter	1.0	1.9	2.2	1.5	-1.4	1.4	-1.4	1.4	1.3
Bone: periosteal estimation	2.0	4.0	4.5	2.1	-2.0	2.0	-1.8	2.0	2.0
Bone: periosteal perimeter	0.7	1.2	1.4	1.1	-1.1	1.1	-1.1	1.2	1.0
Bone: post-yield work	0.2	0.2	0.4	0.6	-0.4	0.4	-0.5	0.4	0.5
Bone: stiffness	1.1	1.8	2.1	1.5	-1.4	1.4	-0.9	1.3	1.3
Bone: tissue strength	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.4	-0.1	-0.1
Bone: trabecular number	1.1	1.7	2.2	-1.2	1.5	-1.5	1.0	-1.3	-1.2
Bone: trabecular spacing	2.1	2.7	3.1	1.6	-1.8	1.8	-1.6	1.6	1.5
Bone: trabecular thickness	0.4	0.5	0.5	0.7	-0.7	0.7	-0.7	0.5	0.7
Bone: trabecular tissue density	0.1	0.2	0.5	0.3	-0.3	0.3	-0.7	0.2	0.3
Breakpoint value in progressive ratio session	0.3	0.3	0.4	-0.6	0.7	-0.7	0.5	-0.5	-0.5
Distance traveled before self-admin	0.8	0.9	1.5	0.9	-0.9	0.9	-0.9	1.2	0.9
Distance traveled after self-admin	0.1	0.1	0.4	0.2	-0.0	0.0	-0.5	0.6	0.5
Delta time in closed arm before/after self-admin	1.6	1.5	2.0	1.2	-1.2	1.2	-1.4	1.2	1.2
Delta time in open arm before/after self-admin	0.8	0.7	1.0	-0.8	0.7	-0.7	1.0	-1.0	-1.0
Diff in mean of infusions in LGA sessions	0.8	0.9	1.1	-1.0	1.0	-1.0	0.8	-1.0	-0.9
Extinction: sum of active levers before priming	0.3	0.3	0.4	-0.5	0.7	-0.7	0.5	-0.4	-0.5
Active lever presses in extinction session 6	0.1	0.1	0.2	0.2	-0.4	0.4	-0.5	-0.1	0.1
Delta distance traveled before/after self-admin	0.5	0.5	0.8	-0.7	0.9	-0.9	0.4	-0.8	-0.6
Delta ambulatory time before/after self-admin	0.7	0.8	1.2	-0.8	1.1	-1.1	0.7	-0.9	-0.6
Time in closed arm before self-admin	0.4	0.4	0.6	-0.7	0.8	-0.8	0.5	-0.7	-0.5
Time in closed arm after self-admin	0.1	0.1	0.1	0.2	-0.2	0.2	-0.3	0.1	0.4
Time in open arm before self-admin	0.2	0.2	0.3	-0.4	0.6	-0.6	0.4	-0.4	-0.4
Time in open arm after self-admin	1.7	1.9	2.2	-1.4	1.3	-1.3	1.2	-1.4	-1.5
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.0	-0.6	1.0	-1.0	0.5	-0.9	-0.6
Time to tail flick, vehicle, before self-admin	2.3	2.3	3.5	1.5	-1.6	1.6	-0.6	1.9	1.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.4	0.4	-0.4	0.3	-0.4	-0.4
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1	0.1	-0.2
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	0.0	-0.0	0.1	0.1	0.2
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	2.2	-1.1	1.0	-1.0	0.6	-1.5	-1.3
Delta time to tail flick, test, before/after SA	1.3	1.1	1.6	1.3	-1.2	1.2	-0.6	1.0	1.1
Ambulatory time before self-admin	0.5	0.5	0.9	0.6	-0.6	0.6	-0.8	0.9	0.7
Ambulatory time after self-admin	0.2	0.2	0.4	-0.4	0.7	-0.7	-0.1	0.0	-0.1
Total heroin consumption	0.5	0.6	1.0	-0.7	1.0	-1.0	0.7	-0.5	-0.4
Area under the delay curve	0.8	0.8	1.3	1.0	-1.1	1.1	-0.7	0.8	0.6
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.3	-0.5	0.5	0.1	0.0	0.1
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	0.5	-0.6	0.6	-0.6	0.3	0.5
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	-0.3	0.3	-0.3	0.5	-0.6	-0.6
Delay disc. indifference point, 24s delay	2.6	2.5	3.0	1.6	-1.7	1.7	-1.6	1.3	1.5
Delay disc. indifference point, 4s delay	1.1	1.1	1.7	1.1	-1.3	1.3	-0.8	1.0	0.7
Delay disc. indifference point, 8s delay	1.6	1.7	2.3	1.4	-1.5	1.5	-1.0	1.2	1.1
Delay discount exponential model param	0.6	0.7	1.0	-0.9	1.0	-1.0	0.7	-0.7	-0.5
Delay discount hyperbolic model param	0.4	0.4	0.7	-0.7	0.8	-0.8	0.4	-0.5	-0.3
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.1	-0.2	0.2	0.1	-0.1	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.2	-0.4	0.4	0.5	0.3	0.1
Time >=10cm from walls, locomotor time 1	1.6	1.6	2.0	1.2	-1.2	1.2	-1.4	1.4	1.3
Bouts of movement, locomotor time 1	0.2	0.2	0.3	-0.5	0.5	-0.5	0.4	-0.3	-0.6
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.2	0.2	-0.2	0.1	-0.0	-0.3
Rest time, locomotor task time 1	0.1	0.1	0.1	0.3	-0.3	0.3	-0.4	0.3	0.2
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.4	-0.3	0.3	-0.2	0.4	0.5
Vertical activity count, locomotor time 1	0.6	0.6	0.9	0.8	-0.8	0.8	-0.5	0.8	1.0
Time >=10cm from walls, locomotor time 2	5.4	5.7	6.7	2.5	-2.6	2.6	-2.0	2.2	2.3
Bouts of movement, locomotor time 2	0.2	0.2	0.7	0.3	-0.3	0.3	-0.8	0.6	0.3
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.3	0.1	-0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	-0.1	0.0	-0.0	-0.2	0.2	-0.3
Distance moved, locomotor task time 2	2.2	2.5	3.4	1.7	-1.5	1.5	-1.4	1.5	1.8
Vertical activity count, locomotor time 2	1.4	1.5	2.2	1.3	-1.0	1.0	-1.4	1.0	1.5
Weight adjusted by age	0.9	1.0	1.4	1.1	-1.0	1.0	-0.8	0.8	1.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	0.0	-0.0	0.0	-0.4	0.4	0.1
Locomotion in novel chamber	0.5	0.6	1.2	-0.8	0.4	-0.4	1.1	-0.9	-0.9
Locomotion in novel chamber post-restriction	2.0	2.4	2.7	1.6	-1.6	1.6	-1.5	1.5	1.5
Progressive ratio	3.9	4.5	5.3	2.0	-2.0	2.0	-2.3	2.3	2.0
Food seeking constrained by brief footshock	0.1	0.1	0.1	-0.3	0.2	-0.2	-0.3	-0.3	-0.2
Seeking ratio, punishment vs. effort	2.5	3.1	3.7	-1.7	1.7	-1.7	1.7	-1.9	-1.7
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.5	-0.5	0.5	-0.1	0.1	0.2
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.5	0.1	-0.1	-0.2	0.5	0.5
Latency to leave start box in cocaine runway	0.5	0.6	0.7	-0.8	0.6	-0.6	0.8	-0.8	-0.8
Latency to leave start box in cocaine runway, F	0.5	0.5	0.8	-0.8	0.5	-0.5	0.8	-0.8	-0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	0.1	-0.1	0.3	-0.1	0.1
Cd content in liver	1.2	1.3	1.5	1.2	-1.1	1.1	-1.2	1.0	1.2
Co content in liver	2.2	2.6	2.9	1.7	-1.6	1.6	-1.2	1.7	1.7
Cu content in liver	3.5	4.2	4.4	-2.0	2.1	-2.1	2.0	-2.1	-2.0
Fe content in liver	4.5	5.3	6.0	2.4	-2.1	2.1	-2.5	2.3	2.4
K content in liver	1.5	1.5	1.9	-1.1	1.4	-1.4	1.3	-1.1	-1.0
Mg content in liver	3.5	3.6	6.1	-1.7	1.8	-1.8	2.5	-1.8	-1.7
Mn content in liver	0.2	0.2	0.4	-0.3	0.5	-0.5	0.6	-0.3	-0.3
Na content in liver	0.1	0.1	0.4	-0.2	0.6	-0.6	-0.2	0.0	0.0
Rb content in liver	0.1	0.1	0.2	0.4	-0.5	0.5	-0.1	0.2	0.3
Se content in liver	3.4	4.1	5.2	-1.9	2.1	-2.1	2.3	-1.9	-1.8
Sr content in liver	0.0	0.0	0.1	-0.1	0.1	-0.1	0.0	-0.3	-0.2
Zn content in liver	0.6	0.6	1.2	0.8	-1.1	1.1	-0.4	0.5	0.5