Hub : Genes

Notch4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression ENSRNOG00000000442 0.37 0.1 0.0e+00 0.38 0.41 0.43 0.43 3.1e-45 8.7e-49 2.5e-51 1.1e-51
2 Adipose mRNA stability ENSRNOG00000000442 0.16 0.07 5.6e-17 0.15 0.16 0.15 0.15 1.6e-16 8.1e-17 1.4e-16 1.1e-16
3 BLA gene expression ENSRNOG00000000442 0.25 0.12 1.2e-09 0.17 0.18 0.18 0.18 2.8e-09 7.2e-10 9.2e-10 6.3e-10
4 Brain gene expression ENSRNOG00000000442 0.19 0.09 2.7e-13 0.11 0.12 0.1 0.12 1.9e-10 4.7e-11 2.5e-09 1.7e-11
5 Brain intron excision ratio chr20:4183497:4184239 0.05 0.03 4.5e-03 0.02 0 0 0.01 7.3e-03 1.5e-01 1.5e-01 4.7e-02
6 LHb gene expression ENSRNOG00000000442 0.22 0.12 2.7e-03 0.03 0.03 -0.01 0.01 6.4e-02 7.3e-02 9.3e-01 2.1e-01
7 Liver gene expression ENSRNOG00000000442 0.64 0.11 0.0e+00 0.65 0.63 0.66 0.65 5.8e-95 2.4e-91 1.4e-96 1.9e-95
8 NAcc gene expression ENSRNOG00000000442 0.16 0.08 5.1e-11 0.1 0.1 0.1 0.1 7.5e-08 4.9e-08 6.5e-08 3.3e-08
9 OFC gene expression ENSRNOG00000000442 0.21 0.11 5.5e-04 0.19 0.13 0.16 0.21 3.3e-05 5.7e-04 1.2e-04 1.0e-05
10 PL gene expression ENSRNOG00000000442 0.11 0.06 2.0e-07 0.07 0.08 0.08 0.08 5.2e-06 1.2e-06 1.5e-06 8.5e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strong Z-scores (below -2 or above 2): lower negative Z-scores are darker blue, higher positive Z-scores are darker red.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
BMI with tail2.16.910.8-0.5-0.13.33.32.23.12.92.72.83.0
BMI without tail2.04.28.22.70.62.01.32.91.61.42.52.61.8
Body weight4.117.526.51.0-0.84.94.74.64.94.64.25.14.2
Epididymis fat weight2.55.812.2-0.73.22.92.91.11.91.13.01.93.5
Glucose2.13.312.5-0.8-3.5-1.8-1.7-1.2-0.8-0.2-2.3-0.6-2.4
Heart weight0.40.63.51.90.2-0.2-0.41.0-0.2-0.10.40.9-0.0
Left kidney weight1.95.38.30.8-0.22.52.52.62.62.32.52.92.5
Right kidney weight1.85.27.61.2-0.42.52.32.82.52.42.52.82.4
Tail length1.23.615.84.0-1.20.7-0.13.00.91.01.22.40.0
Length with tail1.03.88.12.0-1.21.71.42.81.92.01.62.81.1
Length without tail1.83.96.4-0.7-1.32.32.51.72.52.51.42.11.8
Liver weight, left0.91.42.00.4-0.61.31.21.31.41.31.21.41.2
Liver weight, right0.71.23.31.7-1.80.40.11.50.91.10.31.1-0.1
Parametrial fat weight1.63.05.8-0.80.42.22.41.22.01.81.91.32.2
Retroperitoneal fat weight0.31.01.9-0.00.11.21.20.91.10.90.91.41.0
Intraocular pressure0.30.41.0-0.90.9-0.2-0.1-1.0-0.5-0.50.1-0.70.2
Extensor digitorum longus weight0.10.32.2-0.3-1.50.10.20.10.40.7-0.10.5-0.0
Soleus weight0.92.717.00.2-4.10.30.41.21.42.0-0.51.1-0.7
Tibialis anterior weight0.10.20.9-0.11.00.50.60.20.20.10.50.10.6
Tibia length1.54.47.91.4-2.11.91.62.52.12.42.02.81.6
Number of licking bursts0.50.61.9-0.1-1.4-0.6-0.6-0.3-0.3-0.1-1.0-0.5-1.2
Food consumed during 24 hour testing period1.31.53.0-0.8-1.61.31.50.91.61.70.61.00.8
Times rat made contact with spout1.31.55.10.62.3-0.9-0.9-0.8-1.4-1.7-0.6-1.3-0.6
Mean time between licks in bursts0.81.13.70.2-1.9-1.1-1.2-0.6-0.7-0.3-1.1-0.5-1.5
Mean num. licks in bursts0.70.96.00.62.50.20.20.0-0.3-0.70.7-0.01.0
Std. dev. time between licks in bursts0.81.05.80.6-2.4-0.8-0.80.2-0.10.4-0.80.2-1.2
Water consumed over 24 hours0.10.10.9-0.1-0.9-0.2-0.10.10.10.2-0.5-0.0-0.5
Indifference point 0 sec1.62.63.91.81.81.61.41.81.00.72.01.71.8
Indifference point AUC0.50.64.42.10.50.2-0.30.9-0.0-0.10.30.3-0.2
Indifference point function ln k0.30.41.3-0.1-0.7-0.9-0.7-0.2-0.5-0.4-0.8-0.5-1.2
Indifference point function log k0.30.41.3-0.1-0.7-0.9-0.7-0.2-0.5-0.4-0.8-0.5-1.2
Delay discounting total patch changes 0 sec1.62.64.11.82.01.61.41.81.00.62.01.61.8
Delay discounting total patch changes 12 sec1.21.63.31.81.71.20.81.30.60.31.51.01.5
Delay discounting total patch changes 18 sec1.41.94.60.22.11.71.60.71.00.61.70.61.9
Delay discounting total patch changes 24 sec0.50.64.5-0.12.10.20.2-0.6-0.5-0.70.2-0.50.6
Delay discounting total patch changes 6 sec1.21.84.11.72.01.31.01.30.70.31.61.21.5
Delay discounting time to switch 0 sec1.62.44.7-2.0-0.21.82.20.21.81.61.20.82.0
Delay discounting water rate 0 sec0.10.10.40.6-0.10.20.10.60.30.30.10.5-0.1
Delay discounting water rate 12 sec0.20.30.9-0.51.0-0.3-0.3-0.5-0.5-0.7-0.0-0.7-0.1
Delay discounting water rate 18 sec0.10.10.30.20.50.30.40.60.30.20.40.40.4
Delay discounting water rate 24 sec0.10.10.4-0.10.50.20.20.20.1-0.00.60.10.6
Delay discounting water rate 6 sec0.00.10.3-0.60.30.20.30.00.20.10.1-0.00.1
Locomotor activity0.91.45.72.4-0.10.70.52.00.80.71.01.30.4
Locomotor testing distance0.61.02.41.5-0.20.90.71.60.90.80.91.10.6
Locomotor testing rearing1.01.62.50.5-0.91.21.21.41.51.61.11.41.2
Light reinforcement 11.52.75.1-0.7-0.42.02.31.12.22.11.31.02.0
Light reinforcement 21.41.93.6-1.0-1.11.51.80.81.91.90.71.01.3
Reaction time number correct0.81.22.60.61.21.01.00.80.70.51.61.11.6
Reaction time mean minus median1.41.83.1-0.5-1.3-1.6-1.3-1.3-1.2-0.9-1.7-1.5-1.8
Reaction time mean minus median AUC2.32.94.7-1.0-1.2-2.0-1.8-1.9-1.6-1.3-2.1-1.8-2.2
Reaction time num false alarms0.10.20.60.7-0.7-0.0-0.10.40.10.2-0.2-0.2-0.4
Reaction time num false alarms AUC0.20.31.91.4-0.60.2-0.10.90.20.30.10.0-0.3
Reaction time trials correct on left0.81.22.60.61.21.01.00.80.70.51.61.11.6
Reaction time trials on left0.81.12.50.61.21.01.00.80.70.51.61.21.5
Reaction time mean1.31.75.4-1.5-2.3-1.0-0.7-1.1-0.30.1-1.7-1.1-1.6
Reaction time mean AUC1.31.74.6-1.5-2.1-1.0-0.7-1.1-0.4-0.0-1.7-1.1-1.6
Median of all reaction times0.91.25.0-1.6-2.2-0.4-0.2-0.70.20.6-1.2-0.6-1.1
Reaction time omissions0.71.01.8-1.0-1.3-1.1-0.9-1.0-0.6-0.4-1.1-0.9-1.2
Reaction time false alarm rate0.50.71.81.0-1.2-0.6-0.80.2-0.4-0.1-0.9-0.6-1.3
Reaction time premature initiation rate0.30.40.90.1-0.30.60.60.50.60.70.80.90.6
Reaction time premature initiations1.11.63.20.50.41.31.31.11.21.11.81.71.6
Std. dev. reaction times1.31.84.3-0.2-1.7-1.6-1.5-0.9-1.1-0.7-1.7-1.2-2.1
Reaction time trials completed0.81.12.50.61.21.01.00.80.70.51.61.21.5
Reaction time trials AUC0.81.12.40.41.11.01.10.70.80.51.61.11.6
Social response proportion0.70.81.90.4-1.00.70.81.11.11.20.31.40.2
Social responses0.60.82.21.0-0.50.80.71.51.00.90.51.20.3
Social time0.70.95.4-0.7-2.3-0.00.10.20.60.8-0.9-0.4-0.8
Conditioned locomotion1.31.62.9-0.5-1.31.31.41.11.71.71.01.20.9
Cocaine response after cond. corrected0.91.04.5-2.1-1.30.80.9-0.50.91.0-0.2-0.30.1
Cocaine response after cond. not corrected0.80.92.0-0.4-1.41.01.00.81.21.30.40.60.2
Cocaine response before conditioning2.42.912.13.50.20.80.32.70.90.81.42.10.7
Saline control response2.73.66.71.72.21.81.61.91.20.82.61.82.6
Condit. Reinf. active minus inactive responses0.40.52.61.60.20.2-0.01.00.20.10.71.00.3
Condit. Reinf. active-inactive response ratio0.60.62.71.6-0.40.3-0.01.10.30.40.61.20.2
Condit. Reinf. active responses0.20.21.21.10.5-0.2-0.30.3-0.2-0.30.30.40.2
Condit. Reinf. inactive responses0.10.10.60.00.80.20.30.10.1-0.00.30.00.6
Condit. Reinf. lever presses0.81.12.20.61.0-1.3-1.3-0.8-1.4-1.5-0.6-0.6-0.7
Condit. Reinf. lever reinforcers received0.20.31.41.20.5-0.5-0.60.2-0.5-0.60.10.2-0.1
Pavlov. Cond. lever latency0.50.71.5-0.6-1.10.80.90.61.11.20.50.60.6
Pavlov. Cond. magazine entry latency0.40.40.7-0.0-0.3-0.8-0.8-0.6-0.8-0.6-0.8-0.5-0.8
Pavlov. Cond. change in total contacts0.50.71.71.21.3-0.8-0.9-0.2-1.1-1.2-0.2-0.3-0.4
Pavlov. Cond. index score0.50.61.20.50.8-0.9-0.9-0.5-1.1-1.1-0.5-0.5-0.6
Pavlov. Cond. latency score0.30.40.80.60.8-0.6-0.7-0.3-0.9-0.9-0.3-0.3-0.4
Pavlov. Cond. lever contacts0.40.62.90.51.7-0.4-0.4-0.4-0.8-1.0-0.1-0.4-0.1
Pavlov. Cond. magazine entry number0.10.10.20.3-0.10.20.30.40.40.30.30.40.2
Pavlov. Cond. intertrial magazine entries0.40.61.40.4-0.8-0.9-1.0-0.2-0.6-0.4-0.9-0.7-1.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.90.50.8-0.7-0.8-0.4-0.9-0.9-0.4-0.4-0.5
Pavlov. Cond. response bias0.60.91.60.31.2-0.9-0.9-0.8-1.2-1.3-0.7-0.9-0.7
Conditioned reinforcement - actives0.00.00.2-0.1-0.20.10.10.00.10.20.00.50.2
Conditioned reinforcement - inactives0.10.20.80.60.9-0.0-0.10.2-0.2-0.40.20.40.3
Conditioned locomotion0.20.20.4-0.5-0.5-0.5-0.5-0.6-0.4-0.2-0.60.1-0.5
Intermittent access intake day 1-15 change0.40.31.41.01.2-0.1-0.20.2-0.4-0.60.5-0.30.3
Intermittent access intake escalation0.10.10.20.40.3-0.0-0.10.1-0.1-0.20.3-0.30.1
Intermittent access intake escalation 20.80.81.3-0.2-1.0-1.1-1.0-0.7-0.7-0.5-1.1-1.0-1.2
Intermitt. access day 1 inactive lever presses1.41.52.9-0.1-1.71.11.21.11.61.70.81.10.8
Intermitt. access day 15 inactive lever presses0.91.02.11.40.40.90.71.40.80.71.11.30.9
Intermitt. access escalation Index0.90.82.4-1.6-1.2-0.4-0.2-0.9-0.1-0.0-1.1-0.9-0.7
Intermittent access day 1 total infusions1.82.13.2-0.90.2-1.7-1.6-1.8-1.7-1.5-1.6-1.3-1.4
Intermittent access day 15 total infusions0.40.50.9-0.50.4-0.8-0.7-0.9-0.9-0.8-0.6-0.8-0.4
Intermittent access terminal intake (last 3 days)0.40.40.80.20.4-0.8-0.9-0.6-0.9-0.8-0.5-0.3-0.5
Intermittent access total infusions0.60.71.3-0.20.5-1.0-1.0-1.0-1.1-1.1-0.7-0.5-0.7
Intermittent access day 1 locomotion0.10.10.2-0.20.1-0.3-0.3-0.4-0.3-0.2-0.1-0.0-0.0
Intermittent access day 15 total locomotion0.50.51.10.60.00.80.70.80.70.71.00.70.8
Intermittent access total locomotion0.10.10.2-0.20.40.20.3-0.00.20.20.50.30.5
Intermittent access standard deviation1.92.13.31.21.01.51.41.61.21.01.81.61.8
Cocaine induced anxiety0.50.63.1-1.7-1.00.10.4-0.70.30.4-0.5-0.7-0.2
Post-drug Anxiety0.50.51.3-0.7-1.10.60.80.30.91.00.30.30.4
Baseline Anxiety0.50.62.41.60.10.40.11.20.30.30.61.00.3
Lifetime Intake0.50.61.0-0.10.2-1.0-1.0-0.8-1.0-0.9-0.8-0.4-0.8
Incentive Sensitization - Responses0.30.31.1-0.50.4-0.3-0.3-0.6-0.4-0.5-0.3-1.1-0.1
Incentive Sensitization - Breakpoint0.30.31.3-0.70.4-0.3-0.1-0.7-0.4-0.5-0.3-1.10.0
Progressive ratio test 1 active lever presses0.50.50.9-0.1-0.0-0.9-0.9-0.7-0.9-0.7-0.8-0.4-0.9
Progressive ratio test 1 breakpoint0.30.30.6-0.0-0.1-0.7-0.8-0.5-0.7-0.6-0.6-0.2-0.8
Progressive ratio test 1 inactive lever presses0.20.20.5-0.10.40.50.60.20.40.30.60.10.7
Progressive ratio test 2 active lever presses0.40.40.8-0.60.4-0.6-0.5-0.9-0.7-0.7-0.6-0.9-0.4
Progressive ratio test 2 breakpoint0.70.81.5-0.80.7-0.8-0.7-1.2-1.0-1.0-0.7-1.2-0.5
Progressive ratio test 2 inactive lever presses0.60.71.30.0-0.0-1.1-1.1-0.8-1.1-0.9-1.1-0.5-0.9
Total sessions with >9 infusions0.50.50.9-0.6-0.4-0.9-0.8-1.0-0.8-0.6-0.9-0.2-0.8
Short access day 1 total inactive lever presses1.61.84.0-1.2-1.8-1.4-1.2-1.3-0.8-0.4-2.0-0.4-1.7
Short access day 10 total inactive lever presses0.60.71.3-0.3-1.10.80.90.71.11.20.40.20.7
Short access day 1 total infusions2.02.13.8-0.2-0.4-1.8-1.9-1.4-1.7-1.4-1.8-0.7-1.9
Short access day 10 total infusions0.10.10.3-0.0-0.2-0.5-0.5-0.3-0.4-0.4-0.3-0.0-0.5
Short access total infusions0.80.91.70.3-0.1-1.2-1.3-0.7-1.1-1.0-1.0-0.2-1.3
Short access day 1 locomotion0.80.81.1-0.9-1.0-1.0-0.8-1.0-0.7-0.4-1.0-1.1-1.0
Short access day 10 total locomotion1.61.84.01.8-1.40.90.72.01.31.41.11.50.5
Short access total locomotion0.40.40.90.5-0.90.30.20.70.60.80.50.80.2
Compulsive drug intake0.70.73.4-1.1-1.8-0.10.2-0.30.40.6-0.7-0.7-0.5
One hour access (0.3 mA shock)0.70.82.1-1.4-0.6-0.7-0.5-1.1-0.5-0.4-1.0-1.4-0.6
One hour access (shock baseline)0.10.10.4-0.20.6-0.3-0.3-0.4-0.4-0.5-0.2-0.20.1
Number of responses in last shaping day0.80.81.71.3-1.2-0.8-1.00.5-0.4-0.1-1.00.3-1.3
Context. condit. distance diff. score3.74.66.5-2.3-2.4-2.2-1.9-2.5-1.5-1.0-2.5-2.0-2.5
Locomotion velocity, session 11.81.93.30.5-0.2-1.8-1.8-1.3-1.7-1.5-1.4-1.1-1.7
Locomotion distance, session 11.01.32.9-1.30.3-1.0-0.8-1.7-1.1-1.1-1.1-1.5-0.9
Locomotion velocity, session 20.40.41.20.0-0.5-0.7-0.6-0.5-0.6-0.4-1.0-0.8-1.1
Locomotion distance, session 20.91.23.9-2.0-0.7-0.7-0.3-1.4-0.5-0.3-1.4-1.3-1.2
Locomotion velocity, session 30.20.31.30.81.1-0.0-0.20.2-0.3-0.50.40.10.2
Locomotion distance, session 32.02.23.4-1.10.3-1.5-1.4-1.8-1.6-1.6-1.7-1.8-1.5
Stereotopy head waving bouts, day 31.01.22.81.3-0.91.00.71.71.11.20.81.20.4
Stereotopy head waving duration, day 31.01.24.02.0-0.20.80.41.70.70.71.01.40.5
Locomotion velocity, session 73.84.18.8-3.0-0.7-1.7-1.2-2.9-1.4-1.2-2.5-2.4-1.9
Locomotion distance, session 75.67.111.8-2.40.1-2.7-2.5-3.4-2.6-2.4-3.1-3.2-2.7
Stereotopy head waving bouts, day 70.70.84.82.21.0-0.5-0.80.5-0.7-0.80.1-0.0-0.4
Stereotopy head waving duration, day 70.60.74.22.10.60.3-0.01.10.1-0.00.70.60.3
Locomotion velocity, session 81.31.66.20.1-2.5-1.1-1.1-0.3-0.40.0-1.6-0.5-2.0
Locomotion distance, session 83.65.411.5-3.4-2.7-1.9-1.4-2.8-1.2-0.7-2.9-2.3-2.5
Degree of sensitization distance0.20.21.2-0.3-1.1-0.2-0.3-0.10.10.2-0.5-0.2-0.6
Degree of sensitization stereotypy1.01.12.81.71.0-1.0-1.2-0.2-1.2-1.3-0.4-0.6-0.8
Condit. Reinf. active minus inactive responses1.41.62.40.50.8-1.4-1.5-0.8-1.4-1.5-1.4-1.1-1.5
Condit. Reinf. active-inactive response ratio0.30.31.41.01.20.0-0.20.5-0.2-0.50.10.1-0.1
Condit. Reinf. active responses1.11.32.0-0.50.7-1.2-1.1-1.1-1.2-1.3-1.4-1.2-1.3
Condit. Reinf. inactive responses1.51.73.4-1.80.6-1.1-0.8-1.9-1.2-1.2-1.3-1.7-0.7
Incentive salience index mean2.02.45.2-1.0-0.9-1.6-1.5-1.4-1.3-1.1-2.3-1.6-2.1
Condit. Reinf. lever presses2.43.26.0-2.3-2.1-1.6-1.1-1.9-0.9-0.6-2.5-1.8-2.0
Time in familiar zone, hab. session 12.62.55.4-0.22.3-1.3-1.3-1.8-2.0-2.1-0.7-1.7-0.6
Time in novel zone, hab. session 12.12.13.60.8-1.61.21.11.91.81.81.01.80.8
Total zone transitions, hab. session 10.30.40.8-0.5-0.3-0.6-0.6-0.9-0.6-0.5-0.6-0.9-0.5
Total locomotion distance, hab. session 10.30.51.0-1.0-0.4-0.6-0.5-1.0-0.5-0.4-0.6-0.9-0.4
Locomotion velocity, hab. session 10.20.30.5-0.6-0.3-0.5-0.5-0.7-0.5-0.4-0.5-0.7-0.4
Time in familiar zone, hab. session 20.30.31.20.31.10.40.40.20.1-0.10.7-0.10.8
Time in novel zone, hab. session 20.10.10.20.4-0.1-0.1-0.20.3-0.10.0-0.10.4-0.3
Total zone transitions, hab. session 20.30.31.3-1.1-0.50.50.7-0.20.50.60.1-0.30.5
Total locomotion distance, hab. session 20.60.84.6-2.2-0.8-0.10.2-1.2-0.00.1-0.6-1.1-0.1
Locomotion velocity, hab. session 20.81.14.9-2.2-1.0-0.4-0.1-1.4-0.3-0.1-1.0-1.4-0.5
Novel to familiar place preference ratio0.30.40.60.30.3-0.6-0.7-0.5-0.8-0.7-0.6-0.6-0.7
Novelty place preference0.30.30.50.70.3-0.6-0.7-0.2-0.7-0.7-0.5-0.5-0.7
Time in novel zone, NPP test0.30.31.01.00.4-0.6-0.7-0.1-0.7-0.7-0.4-0.3-0.6
Total zone transitions, NPP test1.21.73.7-1.9-0.7-1.2-0.8-1.9-1.1-0.9-1.4-1.5-1.0
Total locomotion distance, NPP test1.31.87.9-2.8-0.8-0.8-0.3-1.9-0.6-0.4-1.4-1.4-0.6
Locomotion velocity, NPP test1.82.610.8-3.3-1.0-1.0-0.4-2.3-0.8-0.5-1.7-1.7-0.9
Pavlov. Cond. lever latency4.96.210.40.71.73.12.92.42.52.03.12.43.2
Pavlov. Cond. magazine entry latency2.53.26.11.0-0.6-2.2-2.3-1.1-1.9-1.7-2.1-1.5-2.5
Pavlov. Cond. change in total contacts1.31.42.80.8-0.5-1.5-1.6-0.4-1.2-1.1-1.4-0.9-1.7
Pavlov. Cond. index score3.94.99.5-0.0-1.4-2.7-2.7-1.8-2.2-1.8-2.8-2.1-3.1
Pavlov. Cond. latency score4.15.29.8-0.0-1.5-2.8-2.7-1.8-2.2-1.8-2.9-2.2-3.1
Pavlov. Cond. lever contacts3.54.27.4-1.0-2.0-2.4-2.2-1.9-1.7-1.3-2.7-1.8-2.7
Pavlov. Cond. magazine entry number1.72.23.8-0.80.31.81.90.91.71.51.61.32.0
Pavlov. Cond. intertrial magazine entries0.40.51.5-1.21.10.50.7-0.40.30.10.40.11.0
Pavlov. Cond. lever-magazine prob. diff.3.94.99.2-0.0-1.3-2.7-2.6-1.8-2.2-1.8-2.8-2.1-3.0
Pavlov. Cond. response bias2.73.36.60.1-1.1-2.2-2.2-1.4-1.8-1.5-2.4-1.6-2.6
Bone: apparent density1.32.25.7-2.00.8-1.2-0.9-2.4-1.5-1.4-0.9-1.9-0.6
Bone surface0.00.00.2-0.2-0.5-0.2-0.1-0.3-0.10.00.2-0.10.0
Bone volume0.10.20.5-0.50.3-0.2-0.1-0.7-0.5-0.40.2-0.40.2
Bone: connectivity density0.91.56.0-2.4-0.3-0.8-0.4-2.0-0.8-0.6-0.8-1.5-0.4
Bone: cortical apparent density1.41.83.70.31.41.61.51.21.20.91.71.01.9
Bone: cortical area0.30.40.80.7-0.00.70.60.90.60.60.70.70.7
Bone: cortical porosity2.22.46.82.61.6-1.4-1.8-0.1-1.8-1.9-0.5-0.4-1.3
Bone: cortical porosity2.02.17.42.70.8-1.4-1.80.1-1.6-1.6-0.7-0.3-1.5
Bone: cortical thickness0.71.13.10.51.81.11.10.80.60.21.30.51.6
Bone: cortical thickness1.51.83.50.01.51.71.71.11.20.91.60.81.9
Bone: cortical tissue density1.41.83.50.41.31.61.51.21.21.01.71.01.9
Bone: elastic displacement0.70.82.41.01.6-0.7-0.9-0.3-1.1-1.3-0.4-0.5-0.6
Bone: elastic work0.10.10.40.60.50.20.20.40.0-0.10.20.30.0
Bone: endosteal estimation1.94.18.02.0-2.41.51.22.62.02.31.62.80.9
Bone: endosteal perimeter0.71.47.70.5-2.80.40.41.11.01.40.11.1-0.3
Bone: final force2.94.87.70.20.32.62.82.12.42.32.42.22.7
Bone: final moment2.13.45.40.30.42.22.31.81.91.82.12.02.3
Bone: marrow area2.14.68.92.1-2.41.61.42.82.12.41.83.01.1
Bone: maximum diameter0.30.64.00.2-2.0-0.3-0.30.20.10.5-0.70.2-0.8
Bone: maximum force1.42.54.00.40.21.81.91.51.61.51.91.72.0
Bone: maximum moment0.91.62.70.60.31.41.41.21.11.11.61.51.6
Bone: minimum diameter0.61.14.40.6-2.10.50.61.21.11.40.21.20.0
Bone: periosteal estimation1.73.46.01.8-1.41.61.42.41.92.01.82.51.3
Bone: periosteal perimeter0.50.92.01.0-1.40.70.61.40.91.10.41.00.1
Bone: post-yield work0.30.42.2-0.3-1.50.20.30.20.50.80.30.60.4
Bone: stiffness1.11.73.5-0.20.41.61.71.01.41.31.61.11.9
Bone: tissue strength0.10.10.2-0.5-0.00.30.4-0.10.20.30.20.40.4
Bone: trabecular number2.13.27.5-2.31.0-1.6-1.3-2.7-1.8-1.8-1.2-2.4-0.9
Bone: trabecular spacing2.43.17.01.9-0.71.71.32.61.81.81.42.31.2
Bone: trabecular thickness0.91.13.3-1.70.7-0.7-0.4-1.8-1.0-0.9-0.6-1.4-0.3
Bone: trabecular tissue density0.60.84.62.10.8-0.5-0.90.4-0.8-0.80.40.1-0.3
Breakpoint value in progressive ratio session0.30.30.6-0.7-0.7-0.5-0.4-0.6-0.2-0.2-0.8-0.5-0.6
Distance traveled before self-admin1.31.42.6-1.2-1.41.21.40.41.51.60.70.61.0
Distance traveled after self-admin1.92.13.61.3-0.31.51.21.91.51.41.81.61.5
Delta time in closed arm before/after self-admin1.21.22.2-0.3-1.11.11.20.91.51.50.71.21.0
Delta time in open arm before/after self-admin0.50.51.50.31.2-0.6-0.7-0.5-1.0-1.00.0-0.4-0.1
Diff in mean of infusions in LGA sessions1.71.94.9-2.2-0.8-1.0-0.7-1.7-0.7-0.6-1.9-1.8-1.0
Extinction: sum of active levers before priming0.20.20.6-0.4-0.7-0.4-0.3-0.3-0.1-0.0-0.8-0.3-0.7
Active lever presses in extinction session 60.20.21.0-1.00.1-0.10.1-0.6-0.0-0.1-0.40.1-0.1
Delta distance traveled before/after self-admin1.31.47.82.81.4-0.0-0.61.4-0.4-0.60.90.80.3
Delta ambulatory time before/after self-admin0.91.06.02.50.80.0-0.51.3-0.2-0.30.70.60.1
Time in closed arm before self-admin0.10.10.20.50.0-0.2-0.3-0.0-0.5-0.3-0.1-0.0-0.2
Time in closed arm after self-admin0.10.10.3-0.2-0.10.40.40.10.30.30.10.30.5
Time in open arm before self-admin1.31.42.60.70.3-1.5-1.6-0.6-1.3-1.4-1.2-1.0-1.4
Time in open arm after self-admin1.61.73.30.90.9-1.6-1.8-0.7-1.7-1.8-0.9-0.8-1.2
Sum of active levers in priming session hrs 5-60.70.61.30.3-0.4-1.1-1.2-0.6-0.9-0.7-0.9-0.3-1.1
Time to tail flick, vehicle, before self-admin0.50.51.6-1.2-0.60.60.9-0.20.70.70.1-0.60.2
Time to tail flick, vehicle, after self-admin0.30.31.2-0.5-1.1-0.3-0.2-0.3-0.00.2-0.6-0.5-0.8
Time to tail flick, test, before self-admin0.10.10.50.10.70.10.1-0.1-0.2-0.30.2-0.50.2
Time to tail flick, test, after self-admin2.72.84.4-0.80.3-1.8-1.8-2.0-2.0-1.9-1.6-2.1-1.5
Delta time to tail flick, vehicle, before/after SA1.51.42.2-0.10.2-1.5-1.5-1.2-1.5-1.4-1.3-0.9-1.4
Delta time to tail flick, test, before/after SA0.80.72.8-1.7-0.2-0.6-0.4-1.4-0.5-0.4-0.8-0.8-0.3
Ambulatory time before self-admin0.30.31.2-1.1-0.70.40.6-0.30.60.70.20.00.4
Ambulatory time after self-admin0.60.71.21.0-0.10.70.51.10.70.71.10.90.8
Total heroin consumption0.00.00.1-0.3-0.1-0.1-0.0-0.2-0.1-0.1-0.1-0.1-0.1
Area under the delay curve0.30.31.41.20.10.10.00.90.20.1-0.10.3-0.6
Delay disc. indifference point, 0s delay0.30.31.5-0.2-1.20.00.10.30.40.6-0.60.0-0.6
Delay disc. indifference point, 16s delay0.20.21.00.71.0-0.1-0.10.3-0.3-0.40.1-0.1-0.4
Delay disc. indifference point, 2s delay0.50.52.31.5-0.6-0.1-0.21.00.20.2-0.20.9-0.7
Delay disc. indifference point, 24s delay0.70.74.02.01.0-0.1-0.31.0-0.3-0.40.30.5-0.5
Delay disc. indifference point, 4s delay1.11.13.31.7-0.10.90.71.81.00.80.81.30.4
Delay disc. indifference point, 8s delay0.20.20.70.70.2-0.2-0.20.5-0.1-0.1-0.5-0.2-0.8
Delay discount exponential model param0.30.31.9-1.4-0.3-0.00.1-1.0-0.00.00.1-0.40.6
Delay discount hyperbolic model param0.40.42.6-1.6-0.2-0.00.1-1.1-0.1-0.00.0-0.50.6
Fecal boli incidents, locomotor time 10.40.41.3-1.1-0.0-0.7-0.4-1.1-0.5-0.4-0.5-0.1-0.1
Change in fecal boli incidents, locomotor task0.70.71.91.0-1.40.50.41.20.81.00.20.6-0.2
Time >=10cm from walls, locomotor time 14.24.37.8-0.5-2.02.22.41.92.72.81.62.11.6
Bouts of movement, locomotor time 10.40.51.2-0.1-0.1-0.7-0.6-0.7-0.7-0.6-0.8-1.1-0.9
Total resting periods, locomotor time 10.40.40.9-0.0-0.2-0.8-0.7-0.6-0.7-0.6-0.7-0.9-0.8
Rest time, locomotor task time 10.20.20.50.3-0.2-0.7-0.7-0.3-0.5-0.5-0.40.0-0.4
Distance moved, locomotor task time 10.70.81.30.40.31.11.11.11.00.91.00.60.7
Vertical activity count, locomotor time 11.51.52.60.20.51.61.61.41.51.21.30.91.3
Time >=10cm from walls, locomotor time 22.12.23.80.8-1.21.51.41.91.82.01.11.80.8
Bouts of movement, locomotor time 20.30.32.01.40.4-0.0-0.30.6-0.3-0.30.20.2-0.3
Total resting periods, locomotor time 20.50.52.71.70.2-0.4-0.80.4-0.6-0.6-0.1-0.0-0.7
Rest time, locomotor task time 20.60.74.3-1.0-2.1-0.00.2-0.10.60.8-0.5-0.1-0.3
Distance moved, locomotor task time 20.50.50.90.20.90.90.90.70.70.60.90.70.7
Vertical activity count, locomotor time 20.60.71.00.20.61.01.01.01.00.80.90.90.8
Weight adjusted by age2.22.56.61.4-0.61.51.22.01.61.61.52.61.1
Seeking ratio, delayed vs. immediate footshock1.51.74.62.10.91.10.81.80.80.51.71.11.3
Locomotion in novel chamber0.10.10.20.30.30.20.10.20.10.10.30.20.5
Locomotion in novel chamber post-restriction0.80.91.50.20.21.21.10.81.00.91.21.21.1
Progressive ratio6.67.711.91.71.03.23.03.12.82.43.42.73.4
Food seeking constrained by brief footshock0.10.10.60.60.8-0.0-0.10.3-0.2-0.30.10.10.1
Seeking ratio, punishment vs. effort3.84.77.7-0.6-0.6-2.6-2.5-2.1-2.4-2.0-2.7-2.1-2.8
Run reversals in cocaine runway, females0.20.21.2-0.51.1-0.00.1-0.5-0.2-0.40.2-0.10.5
Run reversals in cocaine runway, males0.50.50.9-0.0-0.7-0.9-0.9-0.6-0.7-0.5-0.7-0.5-0.9
Latency to leave start box in cocaine runway0.40.51.9-0.9-1.4-0.3-0.2-0.40.10.2-1.0-0.3-0.8
Latency to leave start box in cocaine runway, F0.60.71.4-1.1-1.2-0.7-0.5-0.9-0.3-0.2-1.1-0.7-1.0
Latency to leave start box in cocaine runway, M0.20.20.4-0.2-0.40.50.50.40.60.60.10.30.3
Cd content in liver0.60.63.1-1.80.30.60.9-0.70.40.50.40.20.9
Co content in liver2.12.44.30.40.61.91.71.51.61.41.81.72.1
Cu content in liver1.82.13.4-1.11.5-1.2-1.0-1.8-1.5-1.7-1.4-1.8-1.2
Fe content in liver0.40.51.40.21.20.50.50.10.20.01.10.61.1
K content in liver0.80.81.1-0.8-0.9-0.9-0.8-1.0-0.6-0.4-1.1-1.0-0.9
Mg content in liver3.63.76.0-0.8-2.2-2.3-2.1-1.9-1.6-1.1-2.4-1.7-2.4
Mn content in liver1.21.48.7-0.1-2.9-0.6-0.40.10.30.7-1.3-0.1-1.6
Na content in liver0.20.20.6-0.2-0.1-0.4-0.4-0.2-0.2-0.3-0.5-0.8-0.5
Rb content in liver0.50.62.7-1.6-1.3-0.2-0.0-1.00.00.3-0.6-0.4-0.0
Se content in liver2.83.37.80.6-1.5-2.2-2.3-0.9-1.7-1.4-2.3-1.4-2.8
Sr content in liver0.30.31.1-0.7-1.00.30.40.00.50.60.20.60.2
Zn content in liver0.30.31.7-1.0-1.3-0.00.1-0.40.20.5-0.50.2-0.2