Hub : Genes

E2f4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IC	intron excision ratio	chr19_50085688_50086515	0.09	0.07	3.7e-03	0.05	0.06	0.01	0.05	5.3e-03	2.2e-03	1.3e-01	5.3e-03
2	pVTA	gene expression	E2f4	0.02	0.02	7.3e-03	0.01	0.02	0.01	0.02	2.1e-02	6.0e-03	1.9e-02	1.9e-02
3	Liver	mRNA stability	E2f4	0.03	0.04	9.5e-03	0.02	0.01	0	0.01	3.7e-03	4.4e-02	9.4e-02	1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.0	0.1	0.1	0.3	-0.1	0.4
Area under the delay curve	0.4	0.4	1.3	-0.0	-0.2	-1.1
BMI with tail	0.0	0.1	0.1	0.3	-0.2	-0.1
BMI without tail	0.0	0.0	0.0	0.0	-0.1	-0.0
Body weight	0.3	1.3	1.5	1.2	-1.2	-1.1
Weight adjusted by age	0.1	0.2	0.6	0.1	-0.1	0.7
Bone surface	1.0	1.8	2.4	1.5	-1.4	-1.0
Bone volume	0.7	1.3	2.0	1.4	-1.2	-0.7
Breakpoint value in progressive ratio session	2.3	2.8	3.1	-1.6	1.8	1.7
Number of licking bursts	0.4	0.7	0.9	0.9	-0.9	-0.5
Context. condit. distance diff. score	0.0	0.1	0.1	-0.2	0.1	-0.4
Locomotion velocity, session 1	0.2	0.3	0.6	0.2	-0.3	-0.8
Locomotion distance, session 1	0.1	0.1	0.1	-0.3	0.2	0.3
Locomotion velocity, session 2	0.4	0.5	0.6	-0.8	0.7	0.5
Locomotion distance, session 2	0.0	0.0	0.1	-0.3	0.2	0.1
Locomotion velocity, session 3	0.3	0.3	0.4	-0.6	0.6	0.6
Locomotion distance, session 3	0.0	0.0	0.0	-0.2	-0.0	-0.1
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	0.3	-0.3	-0.3
Stereotopy head waving duration, day 3	0.4	0.4	0.6	0.8	-0.6	-0.6
Locomotion velocity, session 7	0.1	0.1	0.3	-0.1	0.3	0.5
Locomotion distance, session 7	0.0	0.0	0.1	-0.2	0.2	0.0
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.3	-0.2	0.6
Stereotopy head waving duration, day 7	0.2	0.2	0.4	0.7	-0.5	0.1
Locomotion velocity, session 8	0.3	0.3	0.7	-0.2	0.5	0.9
Locomotion distance, session 8	0.2	0.3	0.5	-0.7	0.6	0.0
Degree of sensitization distance	0.0	0.0	0.1	0.1	-0.1	-0.3
Degree of sensitization stereotypy	0.1	0.2	0.2	0.5	-0.4	0.3
Conditioned locomotion	2.1	2.4	2.6	1.6	-1.6	-1.4
Cocaine response after cond. corrected	0.2	0.2	0.3	0.6	-0.5	0.1
Cocaine response after cond. not corrected	0.1	0.1	0.3	0.0	0.0	0.5
Cocaine response before conditioning	1.0	1.2	1.6	-1.3	1.1	0.9
Saline control response	4.6	6.1	6.4	2.5	-2.5	-2.4
Bone: connectivity density	0.2	0.2	0.5	-0.2	0.4	0.7
Bone: cortical apparent density	1.2	1.7	1.9	-1.2	1.3	1.4
Bone: cortical area	0.2	0.3	0.5	0.7	-0.6	-0.3
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.3	0.2
Bone: cortical porosity	0.1	0.1	0.1	-0.4	0.3	0.2
Bone: cortical thickness	0.1	0.1	0.1	0.4	-0.1	0.4
Bone: cortical thickness	0.0	0.0	0.1	0.2	-0.1	-0.3
Bone: cortical tissue density	1.3	1.7	1.9	-1.2	1.3	1.4
Condit. Reinf. active minus inactive responses	3.6	4.0	4.7	-2.2	2.1	1.7
Condit. Reinf. active-inactive response ratio	3.2	3.4	4.1	-2.0	1.9	1.6
Condit. Reinf. active responses	2.2	2.7	3.5	-1.9	1.7	1.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.4	0.1
Incentive salience index mean	1.9	2.3	2.5	-1.6	1.6	1.4
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.4	0.5	0.7
Condit. Reinf. active minus inactive responses	0.7	0.9	1.2	1.0	-1.1	-0.8
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.7	0.8	-0.8	-0.4
Condit. Reinf. active responses	0.4	0.6	0.8	0.8	-0.9	-0.7
Condit. Reinf. inactive responses	0.0	0.1	0.1	-0.3	0.2	0.1
Condit. Reinf. lever presses	2.4	3.3	3.5	-1.8	1.8	1.9
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.3	-0.3	-0.2
Conditioned reinforcement - actives	0.3	0.6	1.0	-1.0	0.7	0.5
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.2	-0.2	-0.2
Conditioned locomotion	0.5	0.6	0.7	0.8	-0.8	-0.7
Patch foraging indifference point 0 sec	3.4	6.2	6.5	2.4	-2.5	-2.5
Patch foraging indifference point AUC	1.4	2.0	2.8	1.7	-1.6	-0.9
Delay disc. indifference point, 0s delay	0.4	0.5	0.7	-0.9	0.8	0.0
Delay disc. indifference point, 16s delay	1.3	1.5	3.6	0.4	-0.8	-1.9
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	0.3	-0.4	-0.6
Delay disc. indifference point, 24s delay	0.3	0.4	1.0	0.1	-0.3	-1.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.6	0.6	0.1
Delay disc. indifference point, 8s delay	0.2	0.3	0.8	-0.0	-0.3	-0.9
Indifference point function ln k	0.1	0.2	0.5	-0.7	0.5	-0.1
Indifference point function log k	0.1	0.2	0.5	-0.7	0.5	-0.1
Patch foraging total patch changes 0 sec	3.4	6.3	6.9	2.4	-2.5	-2.6
Patch foraging total patch changes 12 sec	2.9	3.8	4.2	2.0	-2.1	-1.7
Patch foraging total patch changes 18 sec	3.0	4.6	4.7	2.1	-2.2	-2.2
Patch foraging total patch changes 24 sec	0.1	0.2	0.3	0.6	-0.5	-0.0
Patch foraging total patch changes 6 sec	1.6	2.4	3.2	1.8	-1.7	-1.1
Patch foraging time to switch 0 sec	0.7	1.5	2.0	-1.3	1.4	1.0
Patch foraging water rate 0 sec	1.3	2.8	3.2	1.7	-1.8	-1.5
Patch foraging water rate 12 sec	0.1	0.2	0.3	0.4	-0.5	-0.5
Patch foraging water rate 18 sec	0.1	0.1	0.2	0.2	-0.4	-0.5
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.1	-0.3	-0.4
Patch foraging water rate 6 sec	0.5	0.7	0.9	1.0	-0.9	-0.4
Seeking ratio, delayed vs. immediate footshock	3.1	3.8	4.6	1.8	-1.9	-2.1
Distance traveled before self-admin	0.2	0.3	0.5	0.7	-0.3	0.6
Distance traveled after self-admin	0.0	0.0	0.1	0.2	-0.2	-0.1
Extensor digitorum longus weight	0.6	2.5	2.6	-1.6	1.6	1.5
Bone: elastic displacement	1.6	1.9	2.0	1.4	-1.4	-1.4
Bone: elastic work	0.4	0.5	0.7	0.9	-0.7	-0.6
Bone: endosteal estimation	0.2	0.5	0.9	0.4	-0.6	-1.0
Bone: endosteal perimeter	0.4	0.8	1.1	0.7	-0.9	-1.1
Epididymis fat weight	2.3	8.0	8.5	2.7	-2.9	-2.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	0.4	-0.5	-0.3
Delta time in open arm before/after self-admin	0.6	0.6	1.3	-0.3	0.5	1.1
Diff in mean of infusions in LGA sessions	0.9	1.1	1.7	-0.8	1.0	1.3
Delay discount exponential model param	0.4	0.4	1.2	0.1	0.1	1.1
Extinction: sum of active levers before priming	0.5	0.6	0.8	-0.9	0.9	0.5
Active lever presses in extinction session 6	0.0	0.0	0.0	0.1	-0.2	-0.0
Bone: final force	1.0	1.5	2.0	-1.1	1.2	1.4
Bone: final moment	0.4	0.7	1.0	-0.7	0.8	1.0
Food consumed during 24 hour testing period	1.2	1.6	3.1	0.7	-1.2	-1.8
Glucose	1.6	2.6	2.8	-1.7	1.6	1.5
Heart weight	0.1	0.1	0.3	-0.2	0.2	0.5
Delay discount hyperbolic model param	0.2	0.3	0.7	0.2	-0.0	0.9
Intermittent access intake day 1-15 change	0.6	1.3	2.3	-1.5	1.2	0.4
Intermittent access intake escalation	0.8	1.5	2.6	-1.6	1.3	0.6
Intermittent access intake escalation 2	0.5	0.5	1.0	-1.0	0.7	-0.1
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.0	-0.1	-0.1	-1.0
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.3	-0.4	0.5	0.3
Intermitt. access escalation Index	0.2	0.3	0.4	0.6	-0.6	-0.4
Intermittent access day 1 total infusions	0.0	0.1	0.1	-0.1	-0.1	-0.4
Intermittent access day 15 total infusions	0.8	1.1	2.2	-1.5	1.1	0.1
Intermittent access terminal intake (last 3 days)	1.4	1.8	3.4	-1.8	1.4	0.4
Intermittent access total infusions	1.0	1.2	2.2	-1.5	1.1	0.4
Intermittent access day 1 locomotion	1.4	1.8	2.1	1.3	-1.4	-1.3
Intermittent access day 15 total locomotion	0.2	0.3	0.5	0.5	-0.7	-0.5
Intermittent access total locomotion	0.0	0.0	0.1	0.2	-0.3	-0.2
Intermittent access standard deviation	0.2	0.5	0.9	0.5	-0.5	-0.9
Left kidney weight	1.4	6.7	7.3	-2.7	2.7	2.4
Right kidney weight	1.6	7.1	7.3	-2.7	2.7	2.6
Cocaine induced anxiety	1.9	2.7	3.5	1.9	-1.6	-1.4
Post-drug Anxiety	0.5	0.6	0.7	0.7	-0.7	-0.9
Baseline Anxiety	0.8	0.9	1.8	-1.4	0.9	0.3
Tail length	0.0	0.1	0.2	0.2	-0.4	-0.2
Length with tail	0.1	0.6	0.8	0.8	-0.9	-0.5
Length without tail	0.5	1.6	1.7	1.3	-1.3	-1.2
Times rat made contact with spout	2.0	2.3	2.5	1.4	-1.5	-1.6
Lifetime Intake	0.8	1.0	1.8	-1.3	1.0	0.3
Liver weight, left	0.2	0.3	0.5	0.6	-0.5	-0.7
Liver weight, right	0.7	1.2	1.8	0.9	-1.0	-1.3
Locomotor activity	1.8	2.8	4.3	2.1	-1.8	-0.9
Locomotor testing distance	1.6	2.8	4.0	2.0	-1.8	-1.1
Locomotor testing rearing	0.1	0.2	0.4	0.6	-0.4	-0.0
Locomotion in novel chamber	2.2	2.8	3.1	1.7	-1.8	-1.5
Locomotion in novel chamber post-restriction	1.8	3.0	3.1	1.7	-1.8	-1.7
Fecal boli incidents, locomotor time 1	1.2	1.7	1.9	1.3	-1.2	-1.4
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	-0.8	0.7	0.6
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.9	0.7	-0.9	-0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.2	-0.2	-0.5
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.0	0.1	-0.2
Rest time, locomotor task time 1	0.5	0.7	1.5	-0.4	0.5	1.2
Distance moved, locomotor task time 1	0.2	0.3	0.5	0.4	-0.5	-0.7
Vertical activity count, locomotor time 1	1.1	2.5	4.4	1.2	-1.4	-2.1
Time >=10cm from walls, locomotor time 2	0.8	1.2	2.6	-0.6	0.8	1.6
Bouts of movement, locomotor time 2	0.5	0.8	1.0	-1.0	1.0	0.6
Total resting periods, locomotor time 2	0.6	1.1	1.4	-1.1	1.2	0.8
Rest time, locomotor task time 2	0.3	0.4	0.6	-0.8	0.7	0.0
Distance moved, locomotor task time 2	0.3	0.3	0.6	0.8	-0.6	0.1
Vertical activity count, locomotor time 2	0.8	1.1	1.4	1.2	-1.1	-0.9
Light reinforcement 1	2.2	5.4	5.8	2.4	-2.4	-2.2
Light reinforcement 2	2.6	4.1	4.5	1.9	-2.0	-2.1
Bone: marrow area	0.2	0.4	0.8	0.3	-0.6	-0.9
Bone: maximum diameter	0.5	1.0	1.1	0.9	-1.1	-0.9
Bone: maximum force	0.5	0.8	1.4	-0.7	0.8	1.2
Bone: maximum moment	0.2	0.3	0.6	-0.2	0.4	0.8
Mean time between licks in bursts	0.1	0.1	0.3	0.1	-0.3	-0.6
Mean num. licks in bursts	0.1	0.2	0.5	0.1	-0.2	-0.7
Cd content in liver	0.1	0.1	0.2	-0.3	0.4	0.3
Co content in liver	0.0	0.0	0.1	-0.2	0.2	0.2
Cu content in liver	0.6	0.7	0.9	-1.0	0.9	0.7
Fe content in liver	1.4	1.7	2.6	1.6	-1.4	-0.8
K content in liver	0.1	0.1	0.1	-0.3	0.1	-0.3
Mg content in liver	0.8	0.9	1.5	0.7	-0.8	-1.2
Mn content in liver	0.9	0.9	1.5	0.8	-0.9	-1.2
Na content in liver	0.0	0.0	0.1	-0.1	0.0	0.2
Rb content in liver	0.1	0.1	0.2	-0.5	0.4	-0.0
Se content in liver	0.2	0.2	0.5	-0.2	0.3	0.7
Sr content in liver	1.4	1.2	1.4	1.0	-1.1	-1.2
Zn content in liver	1.1	1.2	1.9	-1.4	1.2	0.7
Bone: minimum diameter	0.1	0.2	0.3	0.5	-0.5	-0.2
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.4	-0.5	-0.4
Time in novel zone, hab. session 1	0.3	0.3	0.3	-0.4	0.6	0.6
Total zone transitions, hab. session 1	0.9	1.3	1.4	1.1	-1.2	-1.1
Total locomotion distance, hab. session 1	1.2	1.7	1.8	1.3	-1.3	-1.3
Locomotion velocity, hab. session 1	1.6	2.2	2.3	1.5	-1.5	-1.5
Time in familiar zone, hab. session 2	0.6	0.6	0.8	0.9	-0.8	-0.6
Time in novel zone, hab. session 2	4.7	4.8	5.1	-2.2	2.3	2.1
Total zone transitions, hab. session 2	2.0	2.6	3.1	1.8	-1.6	-1.4
Total locomotion distance, hab. session 2	1.4	1.8	1.9	1.4	-1.4	-1.3
Locomotion velocity, hab. session 2	1.3	1.8	1.9	1.4	-1.3	-1.3
Novel to familiar place preference ratio	2.3	2.5	2.9	-1.7	1.7	1.4
Novelty place preference	3.7	4.0	4.4	-2.0	2.1	1.9
Time in novel zone, NPP test	3.5	3.7	4.1	-1.9	2.0	1.8
Total zone transitions, NPP test	1.7	2.4	2.9	1.7	-1.6	-1.3
Total locomotion distance, NPP test	0.9	1.2	1.6	1.3	-1.2	-0.8
Locomotion velocity, NPP test	0.8	1.1	1.4	1.2	-1.1	-0.8
Intraocular pressure	0.7	1.0	1.3	-0.8	1.0	1.1
Delta distance traveled before/after self-admin	0.3	0.3	0.5	-0.7	0.5	0.0
Delta ambulatory time before/after self-admin	0.3	0.4	0.8	-0.9	0.7	-0.0
Parametrial fat weight	6.3	14.8	16.3	4.0	-3.9	-3.6
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.1	-0.4	-0.6
Pavlov. Cond. magazine entry latency	0.4	0.5	0.5	-0.7	0.6	0.7
Pavlov. Cond. change in total contacts	1.0	1.0	1.2	-0.9	1.0	1.1
Pavlov. Cond. index score	0.3	0.4	0.5	-0.5	0.6	0.7
Pavlov. Cond. latency score	0.2	0.3	0.4	-0.4	0.5	0.6
Pavlov. Cond. lever contacts	0.6	0.7	1.0	-0.7	0.9	1.0
Pavlov. Cond. magazine entry number	0.4	0.5	0.6	0.8	-0.7	-0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	0.4	-0.6	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.4	0.5	-0.6	0.7	0.7
Pavlov. Cond. response bias	0.2	0.3	0.4	-0.5	0.5	0.6
Pavlov. Cond. lever latency	1.2	1.6	1.7	1.3	-1.3	-1.2
Pavlov. Cond. magazine entry latency	3.3	4.0	4.1	-2.0	2.0	1.9
Pavlov. Cond. change in total contacts	1.8	2.9	3.0	-1.6	1.7	1.7
Pavlov. Cond. index score	3.2	4.3	4.4	-2.1	2.1	2.0
Pavlov. Cond. latency score	3.2	4.2	4.4	-2.1	2.1	2.0
Pavlov. Cond. lever contacts	1.3	1.9	2.1	-1.4	1.4	1.3
Pavlov. Cond. magazine entry number	5.4	6.7	6.9	2.6	-2.6	-2.5
Pavlov. Cond. intertrial magazine entries	4.3	6.5	7.2	2.7	-2.6	-2.3
Pavlov. Cond. lever-magazine prob. diff.	3.6	4.7	5.0	-2.2	2.2	2.1
Pavlov. Cond. response bias	2.8	3.8	4.0	-2.0	2.0	1.9
Time in closed arm before self-admin	3.4	4.3	5.4	2.0	-1.9	-2.3
Time in closed arm after self-admin	2.7	2.8	3.3	1.8	-1.7	-1.6
Time in open arm before self-admin	1.6	1.7	2.3	-1.2	1.1	1.5
Time in open arm after self-admin	1.3	1.4	2.5	-0.9	0.9	1.6
Bone: periosteal estimation	0.3	0.6	0.7	0.7	-0.8	-0.8
Bone: periosteal perimeter	0.7	1.1	1.4	1.2	-1.2	-0.8
Bone: post-yield work	0.4	0.5	0.7	0.8	-0.8	-0.5
Progressive ratio test 1 active lever presses	1.7	2.1	3.1	-1.8	1.4	1.1
Progressive ratio test 1 breakpoint	1.4	1.7	2.7	-1.6	1.3	0.9
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	-0.2	-0.0	-0.3
Progressive ratio test 2 active lever presses	0.8	1.0	1.9	-1.4	0.9	0.3
Progressive ratio test 2 breakpoint	0.9	1.0	2.0	-1.4	1.0	0.4
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.1	-0.4	0.3	0.3
Incentive Sensitization - Responses	0.2	0.3	0.5	-0.7	0.4	-0.3
Incentive Sensitization - Breakpoint	0.2	0.3	0.7	-0.8	0.5	-0.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.7	-0.6	0.7	0.8
Progressive ratio	0.5	0.7	1.9	-0.1	0.5	1.4
Food seeking constrained by brief footshock	1.6	2.0	2.2	-1.4	1.5	1.4
Seeking ratio, punishment vs. effort	0.3	0.4	0.8	-0.9	0.6	-0.2
Retroperitoneal fat weight	5.7	24.4	27.9	5.3	-5.3	-4.2
Reaction time number correct	0.7	1.3	1.9	-1.4	1.2	0.8
Reaction time mean minus median	0.9	2.3	3.2	-1.2	1.5	1.8
Reaction time mean minus median AUC	0.7	1.9	2.6	-1.0	1.4	1.6
Reaction time num false alarms	0.1	0.1	0.2	-0.4	0.3	-0.1
Reaction time num false alarms AUC	0.1	0.1	0.3	0.1	-0.2	-0.6
Reaction time trials correct on left	0.7	1.3	1.9	-1.4	1.2	0.8
Reaction time trials on left	0.7	1.3	1.9	-1.4	1.2	0.8
Reaction time mean	0.6	0.9	2.0	-0.4	0.8	1.4
Reaction time mean AUC	0.8	1.3	2.2	-0.6	1.1	1.5
Median of all reaction times	0.2	0.3	0.9	-0.0	0.4	0.9
Reaction time omissions	0.6	0.8	1.9	0.4	-0.6	-1.4
Reaction time false alarm rate	0.5	0.6	0.8	0.7	-0.8	-0.9
Reaction time premature initiation rate	1.7	2.3	3.0	-1.3	1.5	1.7
Reaction time premature initiations	2.5	4.5	4.8	-2.0	2.1	2.2
Std. dev. reaction times	0.8	1.4	2.7	-0.6	1.1	1.7
Reaction time trials completed	0.7	1.3	1.9	-1.4	1.2	0.8
Reaction time trials AUC	0.8	1.5	2.0	-1.4	1.3	1.0
Run reversals in cocaine runway, females	2.0	2.0	2.3	1.4	-1.5	-1.3
Run reversals in cocaine runway, males	0.8	0.8	0.9	0.8	-0.9	-0.9
Latency to leave start box in cocaine runway	0.3	0.3	0.5	-0.6	0.7	0.3
Latency to leave start box in cocaine runway, F	1.2	1.3	1.5	-1.2	1.2	1.0
Latency to leave start box in cocaine runway, M	0.5	0.5	0.7	0.8	-0.5	-0.7
Std. dev. time between licks in bursts	1.9	2.6	3.0	1.7	-1.7	-1.4
Total sessions with >9 infusions	0.5	0.6	1.3	-1.1	0.8	-0.0
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.0	0.0	0.1
Short access day 10 total inactive lever presses	0.1	0.4	0.5	0.5	-0.6	-0.7
Short access day 1 total infusions	0.1	0.2	0.3	-0.4	0.1	-0.6
Short access day 10 total infusions	0.1	0.1	0.2	-0.4	0.2	-0.3
Short access total infusions	0.7	0.9	1.7	-1.3	1.0	0.2
Short access day 1 locomotion	0.1	0.1	0.1	-0.3	0.1	-0.4
Short access day 10 total locomotion	1.2	2.2	2.6	1.6	-1.6	-1.2
Short access total locomotion	0.3	0.4	0.5	0.6	-0.6	-0.7
One hour access (0.3 mA shock)	0.4	0.5	0.9	-1.0	0.7	0.0
Compulsive drug intake	0.1	0.1	0.2	0.4	-0.3	0.1
One hour access (shock baseline)	0.4	0.6	1.1	-1.0	0.7	-0.2
Social response proportion	0.2	0.2	0.5	-0.7	0.3	-0.1
Social responses	0.0	0.1	0.1	0.0	-0.3	-0.3
Social time	0.1	0.2	0.4	-0.0	-0.3	-0.7
Soleus weight	0.2	0.5	0.6	0.8	-0.7	-0.6
Bone: stiffness	3.1	5.0	5.1	-2.3	2.3	2.2
Tibialis anterior weight	0.2	0.5	0.6	-0.7	0.7	0.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.4	-0.6	0.5	0.5
Time to tail flick, vehicle, after self-admin	2.1	2.7	5.0	1.1	-1.4	-2.2
Time to tail flick, test, before self-admin	4.8	5.0	7.0	1.9	-2.0	-2.6
Time to tail flick, test, after self-admin	0.4	0.4	0.5	0.4	-0.7	-0.7
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	3.0	1.1	-1.1	-1.7
Delta time to tail flick, test, before/after SA	0.9	1.0	1.1	-1.0	0.9	1.0
Tibia length	0.0	0.1	0.2	-0.1	0.4	0.5
Ambulatory time before self-admin	0.4	0.6	1.2	1.1	-0.9	-0.1
Ambulatory time after self-admin	0.2	0.3	0.3	0.5	-0.5	-0.5
Bone: tissue strength	0.4	0.4	0.5	-0.6	0.5	0.7
Total heroin consumption	0.9	1.0	1.4	-1.2	1.2	0.6
Bone: trabecular number	0.1	0.2	0.4	0.7	-0.4	0.1
Bone: trabecular spacing	0.5	0.6	1.5	0.3	-0.6	-1.2
Bone: trabecular thickness	1.4	1.7	3.3	-0.8	1.1	1.8
Bone: trabecular tissue density	0.9	1.3	1.6	-1.0	1.1	1.3
Water consumed over 24 hours	0.6	0.8	1.2	0.7	-0.9	-1.1
Number of responses in last shaping day	0.8	0.8	1.1	-0.9	1.1	0.7