Hub : Genes

Dnajc24

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr3_92455243_92485048 0.02 0.02 8.8e-03 0.01 0.01 0.01 0.01 1.2e-02 1.0e-02 4.4e-02 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density1.32.22.2-1.5
Area under the delay curve0.10.20.2-0.4
BMI with tail0.51.61.6-1.3
BMI without tail2.04.24.2-2.0
Body weight2.711.211.2-3.3
Weight adjusted by age0.91.11.1-1.0
Bone surface1.52.72.7-1.6
Bone volume2.23.73.7-1.9
Breakpoint value in progressive ratio session0.20.20.20.5
Number of licking bursts0.60.70.7-0.8
Context. condit. distance diff. score3.03.63.6-1.9
Locomotion velocity, session 12.02.12.11.5
Locomotion distance, session 10.70.90.91.0
Locomotion velocity, session 20.10.10.10.3
Locomotion distance, session 20.30.40.40.7
Locomotion velocity, session 30.00.00.0-0.1
Locomotion distance, session 30.00.00.0-0.2
Stereotopy head waving bouts, day 30.00.00.00.1
Stereotopy head waving duration, day 30.10.10.1-0.4
Locomotion velocity, session 70.20.20.2-0.5
Locomotion distance, session 70.00.00.00.0
Stereotopy head waving bouts, day 70.80.90.90.9
Stereotopy head waving duration, day 70.40.50.50.7
Locomotion velocity, session 80.10.10.1-0.4
Locomotion distance, session 80.91.31.3-1.2
Degree of sensitization distance0.20.20.20.4
Degree of sensitization stereotypy1.11.21.21.1
Conditioned locomotion2.22.62.61.6
Cocaine response after cond. corrected6.37.17.12.7
Cocaine response after cond. not corrected2.52.82.81.7
Cocaine response before conditioning6.68.08.0-2.8
Saline control response0.50.60.6-0.8
Bone: connectivity density0.60.90.9-1.0
Bone: cortical apparent density0.10.10.10.4
Bone: cortical area1.72.52.5-1.6
Bone: cortical porosity0.10.10.10.4
Bone: cortical porosity0.10.20.2-0.4
Bone: cortical thickness0.20.30.3-0.6
Bone: cortical thickness0.40.50.50.7
Bone: cortical tissue density0.10.10.10.3
Condit. Reinf. active minus inactive responses1.31.51.5-1.2
Condit. Reinf. active-inactive response ratio4.75.15.1-2.3
Condit. Reinf. active responses0.40.40.4-0.7
Condit. Reinf. inactive responses0.80.90.91.0
Incentive salience index mean1.01.21.2-1.1
Condit. Reinf. lever presses0.40.50.5-0.7
Condit. Reinf. active minus inactive responses1.82.22.2-1.5
Condit. Reinf. active-inactive response ratio3.43.63.6-1.9
Condit. Reinf. active responses1.72.42.4-1.5
Condit. Reinf. inactive responses0.40.50.5-0.7
Condit. Reinf. lever presses2.63.53.5-1.9
Condit. Reinf. lever reinforcers received1.92.72.7-1.6
Conditioned reinforcement - actives2.52.52.5-1.6
Conditioned reinforcement - inactives3.33.73.7-1.9
Conditioned locomotion2.32.82.8-1.7
Patch foraging indifference point 0 sec0.00.00.0-0.1
Patch foraging indifference point AUC4.04.64.62.1
Delay disc. indifference point, 0s delay0.60.70.7-0.8
Delay disc. indifference point, 16s delay0.00.00.0-0.1
Delay disc. indifference point, 2s delay1.01.11.1-1.0
Delay disc. indifference point, 24s delay0.40.40.40.6
Delay disc. indifference point, 4s delay0.20.20.2-0.5
Delay disc. indifference point, 8s delay0.60.60.6-0.8
Indifference point function ln k4.15.65.6-2.4
Indifference point function log k4.15.65.6-2.4
Patch foraging total patch changes 0 sec0.00.00.0-0.1
Patch foraging total patch changes 12 sec0.10.10.10.3
Patch foraging total patch changes 18 sec0.50.60.60.8
Patch foraging total patch changes 24 sec0.70.90.9-0.9
Patch foraging total patch changes 6 sec0.00.00.00.1
Patch foraging time to switch 0 sec0.10.20.2-0.4
Patch foraging water rate 0 sec0.10.20.2-0.4
Patch foraging water rate 12 sec2.13.23.2-1.8
Patch foraging water rate 18 sec2.83.83.8-2.0
Patch foraging water rate 24 sec2.33.13.1-1.8
Patch foraging water rate 6 sec0.60.90.9-0.9
Seeking ratio, delayed vs. immediate footshock3.74.24.2-2.1
Distance traveled before self-admin0.00.00.0-0.1
Distance traveled after self-admin3.13.53.5-1.9
Extensor digitorum longus weight0.00.00.00.2
Bone: elastic displacement1.11.31.31.1
Bone: elastic work0.10.10.1-0.3
Bone: endosteal estimation0.10.20.2-0.5
Bone: endosteal perimeter1.02.02.0-1.4
Epididymis fat weight2.25.15.1-2.3
Delta time in closed arm before/after self-admin0.60.60.60.8
Delta time in open arm before/after self-admin0.90.90.90.9
Diff in mean of infusions in LGA sessions0.80.80.8-0.9
Delay discount exponential model param0.10.10.10.3
Extinction: sum of active levers before priming0.10.10.1-0.3
Active lever presses in extinction session 62.01.91.9-1.4
Bone: final force1.11.81.8-1.3
Bone: final moment0.91.41.4-1.2
Food consumed during 24 hour testing period1.92.22.2-1.5
Glucose0.40.60.6-0.8
Heart weight2.73.83.8-1.9
Delay discount hyperbolic model param0.20.20.20.5
Intermittent access intake day 1-15 change0.40.40.40.7
Intermittent access intake escalation0.30.30.30.6
Intermittent access intake escalation 20.00.00.0-0.0
Intermitt. access day 1 inactive lever presses0.00.00.0-0.1
Intermitt. access day 15 inactive lever presses0.10.10.1-0.3
Intermitt. access escalation Index1.81.51.51.2
Intermittent access day 1 total infusions1.01.21.2-1.1
Intermittent access day 15 total infusions0.20.20.2-0.4
Intermittent access terminal intake (last 3 days)0.30.40.4-0.6
Intermittent access total infusions1.11.21.2-1.1
Intermittent access day 1 locomotion0.40.40.4-0.7
Intermittent access day 15 total locomotion0.00.00.0-0.2
Intermittent access total locomotion0.10.10.1-0.3
Intermittent access standard deviation0.50.60.6-0.8
Left kidney weight2.26.36.3-2.5
Right kidney weight3.59.89.8-3.1
Cocaine induced anxiety0.40.40.4-0.7
Post-drug Anxiety3.03.33.3-1.8
Baseline Anxiety0.30.30.3-0.5
Tail length2.47.27.2-2.7
Length with tail2.38.48.4-2.9
Length without tail0.81.81.8-1.3
Times rat made contact with spout0.00.00.0-0.2
Lifetime Intake0.20.30.3-0.5
Liver weight, left3.35.35.3-2.3
Liver weight, right5.18.58.5-2.9
Locomotor activity0.00.10.10.3
Locomotor testing distance0.71.11.1-1.1
Locomotor testing rearing0.40.60.6-0.8
Locomotion in novel chamber2.12.62.6-1.6
Locomotion in novel chamber post-restriction0.60.70.70.8
Fecal boli incidents, locomotor time 13.74.04.02.0
Change in fecal boli incidents, locomotor task3.02.92.9-1.7
Time >=10cm from walls, locomotor time 10.90.90.90.9
Bouts of movement, locomotor time 11.41.51.51.2
Total resting periods, locomotor time 12.42.62.61.6
Rest time, locomotor task time 11.61.81.81.3
Distance moved, locomotor task time 12.02.22.2-1.5
Vertical activity count, locomotor time 12.22.32.3-1.5
Time >=10cm from walls, locomotor time 24.85.15.1-2.3
Bouts of movement, locomotor time 20.30.30.3-0.6
Total resting periods, locomotor time 20.00.00.0-0.1
Rest time, locomotor task time 29.010.410.43.2
Distance moved, locomotor task time 25.36.26.2-2.5
Vertical activity count, locomotor time 29.810.710.7-3.3
Light reinforcement 10.20.40.4-0.6
Light reinforcement 21.52.02.01.4
Bone: marrow area0.10.20.2-0.5
Bone: maximum diameter0.61.11.1-1.1
Bone: maximum force1.72.92.9-1.7
Bone: maximum moment1.32.22.2-1.5
Mean time between licks in bursts0.00.00.00.1
Mean num. licks in bursts0.40.50.50.7
Cd content in liver0.10.10.10.3
Co content in liver2.32.72.71.6
Cu content in liver1.31.51.51.2
Fe content in liver0.40.50.50.7
K content in liver0.10.10.10.4
Mg content in liver0.50.60.60.7
Mn content in liver1.51.71.71.3
Na content in liver0.00.00.0-0.2
Rb content in liver1.21.51.51.2
Se content in liver1.01.21.21.1
Sr content in liver0.10.10.1-0.3
Zn content in liver1.41.51.51.2
Bone: minimum diameter2.54.64.6-2.1
Time in familiar zone, hab. session 11.00.90.91.0
Time in novel zone, hab. session 11.41.31.3-1.2
Total zone transitions, hab. session 10.81.11.1-1.1
Total locomotion distance, hab. session 10.00.00.0-0.0
Locomotion velocity, hab. session 10.00.00.00.0
Time in familiar zone, hab. session 20.00.10.10.2
Time in novel zone, hab. session 20.30.30.3-0.6
Total zone transitions, hab. session 20.00.00.0-0.0
Total locomotion distance, hab. session 20.70.90.91.0
Locomotion velocity, hab. session 20.81.01.01.0
Novel to familiar place preference ratio1.11.11.1-1.1
Novelty place preference1.21.21.2-1.1
Time in novel zone, NPP test1.11.11.1-1.1
Total zone transitions, NPP test1.42.02.01.4
Total locomotion distance, NPP test1.21.61.61.3
Locomotion velocity, NPP test1.01.41.41.2
Intraocular pressure1.31.91.91.4
Delta distance traveled before/after self-admin0.30.40.4-0.6
Delta ambulatory time before/after self-admin0.70.70.7-0.8
Parametrial fat weight0.30.60.6-0.8
Pavlov. Cond. lever latency0.00.00.00.2
Pavlov. Cond. magazine entry latency0.70.90.9-1.0
Pavlov. Cond. change in total contacts0.00.00.0-0.1
Pavlov. Cond. index score0.00.10.1-0.2
Pavlov. Cond. latency score0.00.00.0-0.2
Pavlov. Cond. lever contacts0.00.00.0-0.2
Pavlov. Cond. magazine entry number0.60.70.70.8
Pavlov. Cond. intertrial magazine entries0.50.60.6-0.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.2
Pavlov. Cond. response bias0.20.20.2-0.5
Pavlov. Cond. lever latency3.44.64.62.2
Pavlov. Cond. magazine entry latency0.60.70.7-0.8
Pavlov. Cond. change in total contacts0.91.21.2-1.1
Pavlov. Cond. index score3.03.93.9-2.0
Pavlov. Cond. latency score3.34.14.1-2.0
Pavlov. Cond. lever contacts3.75.15.1-2.3
Pavlov. Cond. magazine entry number1.31.61.61.3
Pavlov. Cond. intertrial magazine entries1.11.41.4-1.2
Pavlov. Cond. lever-magazine prob. diff.2.83.53.5-1.9
Pavlov. Cond. response bias3.04.14.1-2.0
Time in closed arm before self-admin1.92.22.2-1.5
Time in closed arm after self-admin1.01.01.0-1.0
Time in open arm before self-admin0.00.00.00.2
Time in open arm after self-admin0.60.60.60.8
Bone: periosteal estimation0.71.41.4-1.2
Bone: periosteal perimeter1.32.12.1-1.5
Bone: post-yield work0.30.40.4-0.6
Progressive ratio test 1 active lever presses0.00.00.0-0.2
Progressive ratio test 1 breakpoint0.00.00.0-0.2
Progressive ratio test 1 inactive lever presses0.20.20.20.5
Progressive ratio test 2 active lever presses0.40.40.4-0.6
Progressive ratio test 2 breakpoint0.80.90.9-1.0
Progressive ratio test 2 inactive lever presses1.61.91.9-1.4
Incentive Sensitization - Responses0.00.00.00.2
Incentive Sensitization - Breakpoint0.00.00.00.1
Sum of active levers in priming session hrs 5-60.20.20.2-0.4
Progressive ratio0.00.10.10.2
Food seeking constrained by brief footshock0.00.00.00.2
Seeking ratio, punishment vs. effort0.10.20.20.4
Retroperitoneal fat weight15.952.152.1-7.2
Reaction time number correct1.42.02.0-1.4
Reaction time mean minus median0.00.00.0-0.1
Reaction time mean minus median AUC0.30.40.4-0.6
Reaction time num false alarms0.10.10.10.3
Reaction time num false alarms AUC0.20.30.30.6
Reaction time trials correct on left1.42.02.0-1.4
Reaction time trials on left1.31.81.8-1.4
Reaction time mean0.10.20.2-0.4
Reaction time mean AUC0.30.40.4-0.6
Median of all reaction times0.20.30.3-0.6
Reaction time omissions0.70.90.90.9
Reaction time false alarm rate1.11.51.51.2
Reaction time premature initiation rate0.30.40.40.6
Reaction time premature initiations0.00.00.00.1
Std. dev. reaction times0.20.20.2-0.5
Reaction time trials completed1.31.81.8-1.4
Reaction time trials AUC1.41.91.9-1.4
Run reversals in cocaine runway, females1.41.41.4-1.2
Run reversals in cocaine runway, males1.81.71.71.3
Latency to leave start box in cocaine runway0.60.60.60.8
Latency to leave start box in cocaine runway, F0.80.90.91.0
Latency to leave start box in cocaine runway, M0.10.10.10.3
Std. dev. time between licks in bursts2.63.13.1-1.8
Total sessions with >9 infusions0.00.00.0-0.1
Short access day 1 total inactive lever presses0.40.40.4-0.6
Short access day 10 total inactive lever presses0.70.80.8-0.9
Short access day 1 total infusions0.20.20.2-0.5
Short access day 10 total infusions0.00.00.0-0.0
Short access total infusions0.00.00.00.1
Short access day 1 locomotion0.00.00.0-0.1
Short access day 10 total locomotion0.10.10.10.4
Short access total locomotion0.20.20.2-0.4
One hour access (0.3 mA shock)0.10.10.1-0.3
Compulsive drug intake2.42.42.41.6
One hour access (shock baseline)1.82.02.0-1.4
Social response proportion2.42.62.61.6
Social responses0.00.00.0-0.1
Social time7.610.110.13.2
Soleus weight0.10.30.30.5
Bone: stiffness1.52.42.4-1.5
Tibialis anterior weight1.03.53.51.9
Time to tail flick, vehicle, before self-admin0.00.00.00.0
Time to tail flick, vehicle, after self-admin1.31.41.4-1.2
Time to tail flick, test, before self-admin0.00.00.00.1
Time to tail flick, test, after self-admin0.40.50.50.7
Delta time to tail flick, vehicle, before/after SA2.62.62.6-1.6
Delta time to tail flick, test, before/after SA1.00.90.91.0
Tibia length0.10.40.40.6
Ambulatory time before self-admin0.10.10.1-0.3
Ambulatory time after self-admin3.23.63.6-1.9
Bone: tissue strength0.80.80.80.9
Total heroin consumption0.30.30.30.6
Bone: trabecular number1.52.32.3-1.5
Bone: trabecular spacing0.40.50.50.7
Bone: trabecular thickness1.01.21.2-1.1
Bone: trabecular tissue density0.50.70.70.8
Water consumed over 24 hours0.10.10.1-0.3
Number of responses in last shaping day1.01.11.1-1.0