Dnajc19

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Dnajc19	0.03	0.02	2.7e-03	0	0.01	0	0	2.4e-01	2.1e-02	1.6e-01	1.7e-01
2	Adipose	isoform ratio	XM_063282411.1	0.03	0.02	2.0e-03	0.01	0	-0	0	5.7e-02	1.1e-01	6.0e-01	1.1e-01
3	Liver	gene expression	Dnajc19	0.07	0.04	6.8e-07	0.04	0.03	0.03	0.03	3.2e-05	2.0e-04	5.0e-04	5.6e-04
4	Liver	mRNA stability	Dnajc19	0.06	0.04	7.2e-05	0.03	0.01	0.03	0.02	3.9e-04	1.0e-02	6.6e-04	1.4e-03
5	NAcc	gene expression	Dnajc19	0.02	0.01	2.5e-03	0	0.01	0	0	7.7e-02	8.9e-03	1.8e-01	5.8e-02
6	Adipose	gene expression	Dnajc19	0.04	0.02	2.3e-03	-0	0	-0	0	9.0e-01	7.3e-02	3.7e-01	1.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	3.7	6.3	7.5	2.5	-2.7	2.7	2.7	2.3	2.3
Area under the delay curve	0.6	0.6	1.3	1.1	-0.7	0.7	0.7	0.5	0.8
BMI with tail	0.5	1.9	4.9	0.5	-1.3	1.3	1.3	2.2	0.9
BMI without tail	0.8	2.3	3.0	1.2	-1.6	1.6	1.6	1.7	1.2
Body weight	0.2	0.8	2.0	0.3	-0.9	0.9	0.9	1.4	0.2
Weight adjusted by age	0.8	1.2	1.4	-1.0	1.1	-1.1	-1.1	-1.2	-1.0
Bone surface	0.2	0.4	0.5	0.6	-0.7	0.6	0.6	0.7	0.7
Bone volume	0.4	0.8	1.0	1.0	-1.0	0.9	0.9	0.7	0.7
Breakpoint value in progressive ratio session	3.5	4.3	6.3	1.5	-2.2	2.2	2.2	2.5	1.8
Number of licking bursts	1.1	1.8	3.5	0.9	-1.4	1.4	1.4	1.9	1.0
Context. condit. distance diff. score	3.8	4.6	6.4	2.5	-2.4	2.4	2.4	1.2	1.5
Locomotion velocity, session 1	0.8	0.9	2.2	-1.5	0.9	-1.0	-1.0	0.2	-0.8
Locomotion distance, session 1	0.4	0.5	1.2	-1.1	0.5	-0.6	-0.6	0.7	-0.3
Locomotion velocity, session 2	2.5	2.9	5.7	-2.4	1.6	-1.6	-1.6	-0.1	-1.9
Locomotion distance, session 2	0.9	1.3	2.8	-1.7	1.0	-1.1	-1.1	0.2	-1.2
Locomotion velocity, session 3	0.1	0.1	0.5	-0.2	-0.2	0.2	0.2	0.7	0.2
Locomotion distance, session 3	0.3	0.3	0.6	-0.8	0.6	-0.6	-0.6	-0.0	-0.6
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	-0.5	0.3	-0.4	-0.4	-0.2	-0.3
Stereotopy head waving duration, day 3	0.6	0.7	1.0	0.7	-0.9	0.9	0.9	0.8	1.0
Locomotion velocity, session 7	0.8	0.9	1.9	-1.4	0.9	-1.0	-1.0	0.5	-0.8
Locomotion distance, session 7	0.9	1.2	1.8	-1.1	1.1	-1.1	-1.1	-0.5	-1.4
Stereotopy head waving bouts, day 7	0.5	0.5	1.1	0.3	-0.8	0.8	0.8	1.1	0.3
Stereotopy head waving duration, day 7	1.5	1.8	3.0	0.8	-1.4	1.5	1.5	1.7	1.0
Locomotion velocity, session 8	1.8	2.2	3.1	1.4	-1.6	1.5	1.5	1.8	1.2
Locomotion distance, session 8	0.6	0.8	1.1	1.0	-1.0	1.0	1.0	0.9	0.4
Degree of sensitization distance	1.1	1.1	1.7	-0.8	0.9	-1.0	-1.0	-1.2	-1.3
Degree of sensitization stereotypy	2.1	2.3	2.9	1.1	-1.6	1.7	1.7	1.7	1.2
Conditioned locomotion	0.2	0.2	1.0	0.5	-0.0	0.0	0.0	-1.0	-0.3
Cocaine response after cond. corrected	0.3	0.4	2.0	0.7	0.0	-0.1	-0.1	-1.4	-0.1
Cocaine response after cond. not corrected	0.5	0.6	2.7	0.2	0.5	-0.6	-0.6	-1.6	-0.1
Cocaine response before conditioning	0.2	0.2	0.7	-0.3	0.1	-0.1	-0.1	0.6	0.9
Saline control response	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.4	-0.2	0.1
Bone: connectivity density	2.3	3.6	4.1	1.6	-2.0	1.9	1.9	2.0	1.9
Bone: cortical apparent density	0.0	0.1	0.2	0.2	-0.2	0.2	0.2	0.0	-0.4
Bone: cortical area	0.1	0.2	0.2	0.5	-0.4	0.4	0.4	0.3	0.4
Bone: cortical porosity	0.5	0.6	2.1	0.3	-0.5	0.6	0.6	0.4	1.4
Bone: cortical porosity	0.6	0.7	2.3	0.4	-0.6	0.7	0.7	0.5	1.5
Bone: cortical thickness	0.4	0.6	1.3	0.9	-0.7	0.7	0.7	0.2	1.1
Bone: cortical thickness	0.2	0.2	0.5	-0.7	0.3	-0.2	-0.2	0.6	-0.3
Bone: cortical tissue density	0.0	0.1	0.2	0.2	-0.2	0.2	0.2	0.0	-0.5
Condit. Reinf. active minus inactive responses	1.7	1.9	2.4	-1.6	1.3	-1.5	-1.5	-1.0	-1.3
Condit. Reinf. active-inactive response ratio	1.3	1.4	1.8	-1.1	1.1	-1.2	-1.2	-1.3	-1.1
Condit. Reinf. active responses	0.7	0.9	2.3	-1.5	0.9	-0.9	-0.9	0.2	-0.7
Condit. Reinf. inactive responses	0.5	0.6	2.8	-0.4	-0.3	0.4	0.4	1.7	0.6
Incentive salience index mean	1.8	2.2	2.8	-1.7	1.5	-1.6	-1.6	-0.9	-1.3
Condit. Reinf. lever presses	0.5	0.6	1.3	-1.2	0.9	-0.9	-0.9	0.1	-0.4
Condit. Reinf. active minus inactive responses	1.1	1.4	2.1	-1.2	1.5	-1.4	-1.4	-0.7	-0.7
Condit. Reinf. active-inactive response ratio	1.4	1.7	2.3	-0.9	1.4	-1.4	-1.4	-1.5	-1.1
Condit. Reinf. active responses	2.4	3.3	4.6	-2.1	2.1	-2.1	-2.1	-0.9	-1.3
Condit. Reinf. inactive responses	1.1	1.4	3.3	-1.8	1.2	-1.3	-1.3	0.0	-0.7
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	0.6	-0.5	-0.5	-0.1	-0.2
Condit. Reinf. lever reinforcers received	2.1	3.0	4.2	-2.0	2.0	-1.9	-1.9	-0.8	-1.3
Conditioned reinforcement - actives	0.6	0.9	2.0	-1.4	1.0	-1.0	-1.0	-0.1	-0.9
Conditioned reinforcement - inactives	0.0	0.1	0.2	-0.4	0.2	-0.2	-0.2	0.0	-0.2
Conditioned locomotion	0.8	1.0	2.7	-1.6	0.9	-0.9	-0.9	0.4	-0.9
Patch foraging indifference point 0 sec	1.0	1.9	2.3	1.3	-1.5	1.5	1.5	1.5	0.9
Patch foraging indifference point AUC	1.3	1.9	4.6	0.4	-1.3	1.3	1.3	2.1	1.4
Delay disc. indifference point, 0s delay	0.3	0.4	0.6	-0.8	0.6	-0.6	-0.6	-0.3	-0.6
Delay disc. indifference point, 16s delay	1.2	1.3	1.9	1.4	-1.1	1.1	1.1	0.9	1.1
Delay disc. indifference point, 2s delay	0.4	0.4	0.8	0.9	-0.6	0.6	0.6	0.5	0.6
Delay disc. indifference point, 24s delay	0.7	0.8	1.6	1.3	-0.8	0.8	0.8	0.6	0.8
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.4	-0.6	0.6	0.6	0.6	0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	0.6	-0.1	0.1	0.1	-0.2	0.2
Indifference point function ln k	1.1	1.9	4.6	-0.4	1.3	-1.2	-1.2	-2.1	-1.5
Indifference point function log k	1.1	1.9	4.6	-0.4	1.3	-1.2	-1.2	-2.1	-1.5
Patch foraging total patch changes 0 sec	0.9	1.7	2.0	1.3	-1.4	1.4	1.4	1.4	0.9
Patch foraging total patch changes 12 sec	1.5	1.9	2.1	1.3	-1.5	1.4	1.4	1.4	1.4
Patch foraging total patch changes 18 sec	0.8	1.2	1.8	0.7	-1.2	1.2	1.2	1.3	0.9
Patch foraging total patch changes 24 sec	3.9	6.7	9.7	1.9	-2.7	2.7	2.7	3.1	2.2
Patch foraging total patch changes 6 sec	4.7	7.1	7.8	2.3	-2.8	2.7	2.7	2.7	2.7
Patch foraging time to switch 0 sec	0.1	0.2	0.6	0.0	0.4	-0.3	-0.3	-0.8	-0.5
Patch foraging water rate 0 sec	0.5	1.1	1.2	1.1	-1.1	1.1	1.1	0.7	1.1
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.1
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.5	0.6	-0.5	-0.5	-0.2	-0.4
Patch foraging water rate 24 sec	1.7	2.4	3.7	1.3	-1.5	1.6	1.6	1.9	1.2
Patch foraging water rate 6 sec	0.0	0.1	0.1	0.4	-0.2	0.2	0.2	0.0	0.4
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	0.5	-0.8	0.8	0.8	1.0	0.8
Distance traveled before self-admin	1.9	2.5	3.0	1.4	-1.6	1.6	1.6	1.7	1.5
Distance traveled after self-admin	0.6	0.8	2.3	0.2	-0.8	0.8	0.8	1.5	0.6
Extensor digitorum longus weight	0.4	1.5	5.6	0.0	-0.9	0.9	0.9	2.4	0.8
Bone: elastic displacement	0.1	0.1	0.3	0.6	-0.3	0.2	0.2	-0.6	0.2
Bone: elastic work	0.4	0.5	2.0	0.1	0.4	-0.5	-0.5	-1.4	-0.4
Bone: endosteal estimation	0.4	0.9	1.6	-1.2	0.9	-0.9	-0.9	0.1	-1.3
Bone: endosteal perimeter	0.5	1.1	1.4	-1.2	1.1	-1.1	-1.1	-0.4	-1.1
Epididymis fat weight	0.0	0.0	0.1	-0.2	0.3	-0.2	-0.2	-0.1	-0.3
Delta time in closed arm before/after self-admin	0.8	0.7	1.1	1.0	-0.9	0.9	0.9	0.6	0.9
Delta time in open arm before/after self-admin	0.6	0.6	1.0	-0.5	0.8	-0.8	-0.8	-1.0	-0.7
Diff in mean of infusions in LGA sessions	0.5	0.6	0.7	0.8	-0.9	0.9	0.9	0.4	0.6
Delay discount exponential model param	0.7	0.8	1.5	-1.2	0.8	-0.8	-0.8	-0.6	-0.9
Extinction: sum of active levers before priming	0.8	0.9	1.0	-1.0	1.0	-1.0	-1.0	-0.8	-0.9
Active lever presses in extinction session 6	0.3	0.3	0.4	0.5	-0.6	0.6	0.6	0.6	0.5
Bone: final force	0.1	0.2	0.4	-0.6	0.4	-0.3	-0.3	0.6	-0.1
Bone: final moment	0.0	0.1	0.3	-0.2	0.1	-0.1	-0.1	0.6	0.1
Food consumed during 24 hour testing period	0.0	0.0	0.3	-0.1	0.1	-0.1	-0.1	0.1	-0.5
Glucose	0.8	1.3	1.7	-1.0	1.3	-1.3	-1.3	-1.1	-0.9
Heart weight	0.1	0.1	0.2	0.1	-0.4	0.3	0.3	0.4	0.2
Delay discount hyperbolic model param	0.7	0.7	1.4	-1.2	0.8	-0.8	-0.8	-0.6	-0.9
Intermittent access intake day 1-15 change	0.3	0.6	0.7	0.6	-0.8	0.8	0.8	0.8	0.7
Intermittent access intake escalation	0.4	0.8	1.1	0.6	-0.9	0.9	0.9	1.0	0.8
Intermittent access intake escalation 2	0.0	0.0	0.0	0.0	-0.1	0.1	0.1	0.2	0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.3	-0.1	0.1	0.1	-0.3	0.1
Intermitt. access day 15 inactive lever presses	0.3	0.7	0.8	-0.8	0.9	-0.9	-0.9	-0.9	-0.8
Intermitt. access escalation Index	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	-0.1	0.1
Intermittent access day 1 total infusions	4.1	6.7	8.4	-2.9	2.7	-2.7	-2.7	-1.9	-2.5
Intermittent access day 15 total infusions	0.3	0.4	1.3	-1.1	0.5	-0.5	-0.5	0.3	-0.6
Intermittent access terminal intake (last 3 days)	1.4	1.8	3.2	-1.8	1.4	-1.4	-1.4	-0.6	-1.3
Intermittent access total infusions	1.8	2.1	4.2	-2.1	1.4	-1.4	-1.4	-0.3	-1.4
Intermittent access day 1 locomotion	2.5	3.2	5.4	-2.3	1.9	-1.9	-1.9	-0.7	-1.7
Intermittent access day 15 total locomotion	0.2	0.4	2.0	-0.7	-0.2	0.2	0.2	1.4	0.0
Intermittent access total locomotion	0.5	0.6	1.7	-1.3	0.5	-0.5	-0.5	0.9	-0.5
Intermittent access standard deviation	0.1	0.2	0.2	0.4	-0.4	0.4	0.4	0.3	0.4
Left kidney weight	0.1	0.7	1.5	1.2	-0.9	0.9	0.9	-0.3	-0.2
Right kidney weight	0.5	2.5	3.2	1.7	-1.8	1.8	1.8	1.2	1.0
Cocaine induced anxiety	0.4	0.5	0.9	-0.9	0.8	-0.8	-0.8	-0.2	-0.7
Post-drug Anxiety	0.5	0.5	1.0	-1.0	0.7	-0.7	-0.7	-0.1	-0.7
Baseline Anxiety	0.0	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.0
Tail length	0.0	0.2	0.8	0.5	0.1	0.1	0.1	-0.9	-0.2
Length with tail	0.1	0.6	1.0	-0.5	0.8	-0.7	-0.7	-1.0	-1.0
Length without tail	0.1	0.3	0.6	-0.7	0.5	-0.5	-0.5	0.0	-0.8
Times rat made contact with spout	1.4	1.6	2.5	-1.2	1.3	-1.3	-1.3	-1.0	-1.6
Lifetime Intake	2.1	2.6	4.6	-2.1	1.6	-1.6	-1.6	-0.6	-1.5
Liver weight, left	2.2	3.6	4.8	-2.2	1.9	-1.9	-1.9	-1.1	-2.1
Liver weight, right	0.1	0.2	0.6	-0.3	0.3	-0.3	-0.3	-0.8	-0.6
Locomotor activity	1.8	2.8	3.5	-1.6	1.9	-1.9	-1.9	-1.6	-0.9
Locomotor testing distance	1.2	2.1	3.6	-1.9	1.6	-1.6	-1.6	-0.5	-0.7
Locomotor testing rearing	0.0	0.1	0.1	-0.3	0.3	-0.4	-0.4	-0.1	0.3
Locomotion in novel chamber	0.2	0.3	0.7	-0.9	0.5	-0.5	-0.5	0.2	-0.5
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	0.4	-0.3	0.3	0.3	0.3	0.5
Fecal boli incidents, locomotor time 1	1.4	2.0	3.7	-0.9	1.4	-1.4	-1.4	-1.9	-1.4
Change in fecal boli incidents, locomotor task	0.6	0.6	1.6	0.3	-0.7	0.7	0.7	1.3	0.7
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.2	0.4	-0.4	-0.4	-0.3	-0.2
Bouts of movement, locomotor time 1	0.1	0.1	0.4	0.1	0.1	-0.1	-0.1	-0.7	-0.1
Total resting periods, locomotor time 1	0.2	0.2	1.1	0.2	0.2	-0.2	-0.2	-1.1	-0.2
Rest time, locomotor task time 1	1.3	1.6	1.8	-1.0	1.4	-1.4	-1.4	-1.3	-1.1
Distance moved, locomotor task time 1	1.2	1.8	3.2	0.7	-1.4	1.4	1.4	1.8	1.1
Vertical activity count, locomotor time 1	0.8	2.0	2.3	1.2	-1.5	1.5	1.5	1.5	1.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	-0.2	0.3	-0.3	-0.3	-0.3	-0.2
Bouts of movement, locomotor time 2	0.4	0.6	1.2	1.1	-0.7	0.7	0.7	-0.4	0.8
Total resting periods, locomotor time 2	0.2	0.3	0.8	0.9	-0.5	0.5	0.5	-0.6	0.6
Rest time, locomotor task time 2	0.0	0.0	0.1	0.1	0.2	-0.2	-0.2	-0.3	0.0
Distance moved, locomotor task time 2	0.1	0.2	0.6	-0.6	-0.0	0.0	0.0	0.8	-0.1
Vertical activity count, locomotor time 2	0.5	0.6	1.4	-1.2	0.8	-0.8	-0.8	0.1	-0.7
Light reinforcement 1	0.2	0.4	0.7	-0.3	0.7	-0.7	-0.7	-0.8	-0.1
Light reinforcement 2	0.1	0.1	0.5	-0.1	0.3	-0.2	-0.2	-0.7	-0.5
Bone: marrow area	0.4	0.8	1.5	-1.1	0.8	-0.8	-0.8	0.2	-1.2
Bone: maximum diameter	0.1	0.1	0.1	0.3	-0.4	0.4	0.4	0.3	0.2
Bone: maximum force	0.2	0.4	0.6	-0.6	0.8	-0.7	-0.7	-0.3	-0.5
Bone: maximum moment	0.1	0.2	0.3	-0.2	0.6	-0.5	-0.5	-0.4	-0.4
Mean time between licks in bursts	0.6	1.5	4.3	-0.3	1.1	-1.1	-1.1	-2.1	-1.1
Mean num. licks in bursts	1.9	3.0	4.3	-1.4	1.8	-1.8	-1.8	-2.1	-1.5
Cd content in liver	2.0	2.2	3.2	-1.2	1.8	-1.5	-1.5	-1.6	-1.2
Co content in liver	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.4	-0.1	-0.3
Cu content in liver	0.2	0.2	0.6	-0.1	0.3	-0.2	-0.2	-0.8	-0.7
Fe content in liver	0.4	0.5	1.2	-0.4	0.6	-0.6	-0.6	-1.1	-0.5
K content in liver	0.8	0.8	1.4	1.2	-1.0	0.9	0.9	0.1	0.6
Mg content in liver	0.7	0.7	1.8	1.3	-0.9	0.9	0.9	-0.3	0.5
Mn content in liver	0.4	0.4	1.1	1.0	-0.5	0.5	0.5	-0.5	0.6
Na content in liver	0.3	0.3	0.6	0.4	-0.6	0.6	0.6	0.8	0.3
Rb content in liver	0.9	1.0	1.5	0.9	-1.2	1.1	1.1	0.2	1.1
Se content in liver	0.9	1.1	1.3	-0.9	1.0	-1.1	-1.1	-1.1	-1.0
Sr content in liver	0.1	0.1	0.3	-0.4	-0.0	-0.2	-0.2	0.6	0.1
Zn content in liver	0.1	0.1	0.3	0.2	0.1	-0.1	-0.1	-0.5	-0.6
Bone: minimum diameter	0.3	0.5	0.6	-0.5	0.8	-0.8	-0.8	-0.7	-0.8
Time in familiar zone, hab. session 1	0.6	0.6	0.7	-0.7	0.8	-0.8	-0.8	-0.6	-0.8
Time in novel zone, hab. session 1	3.3	3.3	4.3	1.8	-1.9	1.8	1.8	1.6	2.1
Total zone transitions, hab. session 1	0.6	0.9	2.2	0.4	-0.7	0.7	0.7	1.5	1.1
Total locomotion distance, hab. session 1	3.1	4.3	7.1	1.5	-1.9	1.9	1.9	2.7	2.4
Locomotion velocity, hab. session 1	2.7	3.8	6.7	1.3	-1.7	1.7	1.7	2.6	2.3
Time in familiar zone, hab. session 2	0.1	0.1	0.5	0.2	0.1	-0.1	-0.1	-0.7	0.4
Time in novel zone, hab. session 2	1.1	1.1	2.1	0.7	-1.1	1.1	1.1	1.5	0.6
Total zone transitions, hab. session 2	0.1	0.1	0.4	-0.4	0.2	-0.2	-0.2	0.6	0.1
Total locomotion distance, hab. session 2	0.1	0.2	0.8	-0.2	-0.1	0.1	0.1	0.9	0.6
Locomotion velocity, hab. session 2	0.1	0.2	0.7	-0.4	0.2	-0.2	-0.2	0.8	0.3
Novel to familiar place preference ratio	7.3	8.0	9.2	3.0	-2.9	3.0	3.0	2.1	2.8
Novelty place preference	9.4	10.1	11.5	3.4	-3.3	3.3	3.3	2.4	3.2
Time in novel zone, NPP test	10.6	11.3	12.9	3.6	-3.5	3.6	3.6	2.6	3.3
Total zone transitions, NPP test	1.0	1.4	3.2	-1.8	1.2	-1.2	-1.2	0.1	-1.0
Total locomotion distance, NPP test	0.4	0.6	1.4	-1.2	0.8	-0.8	-0.8	0.2	-0.4
Locomotion velocity, NPP test	0.7	1.0	2.4	-1.5	1.1	-1.1	-1.1	0.1	-0.6
Intraocular pressure	1.0	1.5	1.8	-1.0	1.2	-1.3	-1.3	-1.3	-1.1
Delta distance traveled before/after self-admin	1.0	1.1	1.7	-1.3	1.1	-1.1	-1.1	-0.6	-1.0
Delta ambulatory time before/after self-admin	0.5	0.6	1.2	-1.1	0.8	-0.8	-0.8	-0.3	-0.8
Parametrial fat weight	0.7	1.7	2.9	-1.7	1.4	-1.3	-1.3	-0.3	-1.4
Pavlov. Cond. lever latency	1.3	1.6	2.3	1.4	-1.5	1.4	1.4	0.5	1.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.1	0.4	-0.2	-0.2	0.6	-0.2
Pavlov. Cond. change in total contacts	0.4	0.5	0.7	-0.6	0.8	-0.8	-0.8	-0.5	-0.6
Pavlov. Cond. index score	0.6	0.8	1.2	-1.0	1.1	-0.9	-0.9	0.3	-0.9
Pavlov. Cond. latency score	1.0	1.3	1.9	-1.2	1.4	-1.2	-1.2	-0.1	-1.1
Pavlov. Cond. lever contacts	1.6	1.9	2.7	-1.5	1.6	-1.5	-1.5	-0.6	-1.4
Pavlov. Cond. magazine entry number	0.1	0.2	1.0	-0.0	-0.1	-0.0	-0.0	-1.0	0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.1	-0.3	0.3	-0.4	-0.4	-1.0	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.9	0.9	-0.7	-0.7	0.3	-0.8
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.3	0.4	-0.2	-0.2	0.7	-0.5
Pavlov. Cond. lever latency	0.4	0.6	1.3	-0.4	0.6	-0.7	-0.7	-1.2	-1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	-0.2	0.2	0.2	-0.2	-0.3
Pavlov. Cond. change in total contacts	0.3	0.5	1.0	-1.0	0.8	-0.8	-0.8	0.0	-0.3
Pavlov. Cond. index score	0.1	0.1	0.3	0.0	-0.2	0.2	0.2	0.6	0.1
Pavlov. Cond. latency score	0.0	0.0	0.2	-0.1	-0.1	0.1	0.1	0.4	-0.1
Pavlov. Cond. lever contacts	0.5	0.8	1.4	0.6	-0.8	0.8	0.8	1.2	1.0
Pavlov. Cond. magazine entry number	0.2	0.2	0.4	-0.3	0.5	-0.5	-0.5	-0.6	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.5	-0.6	0.1	-0.1	-0.1	0.7	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.3	-0.1	-0.1	0.1	0.1	0.5	-0.0
Pavlov. Cond. response bias	0.3	0.5	0.8	0.4	-0.6	0.6	0.6	0.9	0.7
Time in closed arm before self-admin	0.7	0.8	1.1	0.9	-1.1	1.1	1.1	0.6	0.7
Time in closed arm after self-admin	0.8	0.8	1.2	1.1	-1.0	1.0	1.0	0.3	0.8
Time in open arm before self-admin	0.1	0.1	0.5	0.2	-0.2	0.2	0.2	0.7	0.4
Time in open arm after self-admin	0.1	0.1	0.2	-0.2	0.4	-0.4	-0.4	-0.4	-0.3
Bone: periosteal estimation	0.1	0.2	0.5	-0.6	0.4	-0.4	-0.4	0.2	-0.7
Bone: periosteal perimeter	0.0	0.1	0.1	-0.1	0.3	-0.3	-0.3	-0.3	0.0
Bone: post-yield work	1.4	2.0	2.8	-1.2	1.6	-1.4	-1.4	-1.2	-1.7
Progressive ratio test 1 active lever presses	2.4	2.9	5.6	-2.4	1.7	-1.7	-1.7	-0.4	-1.6
Progressive ratio test 1 breakpoint	2.5	3.1	6.2	-2.5	1.8	-1.8	-1.8	-0.4	-1.7
Progressive ratio test 1 inactive lever presses	1.6	2.2	3.1	-1.8	1.6	-1.6	-1.6	-1.0	-1.4
Progressive ratio test 2 active lever presses	1.1	1.3	3.6	-1.9	1.0	-1.0	-1.0	0.6	-1.0
Progressive ratio test 2 breakpoint	1.0	1.1	3.2	-1.8	0.9	-0.9	-0.9	0.7	-0.9
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.9	-0.9	0.5	-0.5	-0.5	0.1	-0.5
Incentive Sensitization - Responses	0.4	0.6	1.6	-1.3	0.6	-0.6	-0.6	0.6	-0.6
Incentive Sensitization - Breakpoint	0.4	0.5	1.6	-1.2	0.5	-0.5	-0.5	0.6	-0.6
Sum of active levers in priming session hrs 5-6	2.6	2.4	3.6	-1.9	1.6	-1.6	-1.6	-0.9	-1.5
Progressive ratio	0.1	0.1	0.3	0.2	-0.2	0.2	0.2	0.6	0.5
Food seeking constrained by brief footshock	0.2	0.3	0.5	0.7	-0.5	0.5	0.5	0.3	0.5
Seeking ratio, punishment vs. effort	0.4	0.6	0.7	0.9	-0.9	0.9	0.9	0.4	0.6
Retroperitoneal fat weight	0.2	0.8	1.8	-1.3	0.9	-0.8	-0.8	0.3	-0.9
Reaction time number correct	1.8	3.5	5.8	-2.4	2.0	-2.0	-2.0	-1.0	-1.6
Reaction time mean minus median	0.0	0.0	0.2	0.1	0.0	0.0	0.0	-0.4	-0.2
Reaction time mean minus median AUC	0.1	0.2	0.4	0.5	-0.5	0.6	0.6	0.2	0.3
Reaction time num false alarms	0.1	0.1	0.3	-0.1	-0.2	0.2	0.2	0.5	0.6
Reaction time num false alarms AUC	0.0	0.1	0.2	-0.4	0.0	-0.0	-0.0	0.5	0.2
Reaction time trials correct on left	1.8	3.5	5.8	-2.4	2.0	-2.0	-2.0	-1.0	-1.6
Reaction time trials on left	2.0	3.7	5.9	-2.4	2.0	-2.1	-2.1	-1.1	-1.6
Reaction time mean	1.2	1.9	2.8	-1.3	1.4	-1.3	-1.3	-1.7	-1.3
Reaction time mean AUC	0.9	1.4	2.4	-1.0	1.2	-1.1	-1.1	-1.6	-1.0
Median of all reaction times	1.4	2.0	3.0	-1.3	1.4	-1.3	-1.3	-1.7	-1.3
Reaction time omissions	0.9	1.3	3.8	-0.5	1.0	-1.0	-1.0	-1.9	-0.9
Reaction time false alarm rate	0.9	1.3	1.7	1.0	-1.1	1.1	1.1	1.1	1.3
Reaction time premature initiation rate	0.9	1.3	2.6	1.6	-1.1	1.1	1.1	-0.1	1.2
Reaction time premature initiations	0.0	0.1	0.4	0.1	0.1	-0.1	-0.1	-0.6	0.1
Std. dev. reaction times	0.0	0.1	0.3	-0.2	0.2	-0.1	-0.1	-0.5	-0.4
Reaction time trials completed	2.0	3.7	5.9	-2.4	2.0	-2.1	-2.1	-1.1	-1.6
Reaction time trials AUC	1.8	3.5	5.5	-2.3	2.0	-2.0	-2.0	-1.0	-1.5
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.0	-0.3	0.3	0.3	0.5	0.2
Run reversals in cocaine runway, males	0.7	0.7	0.9	-0.9	0.9	-0.9	-0.9	-0.2	-0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.7	-0.1	0.4	-0.4	-0.4	-0.8	-0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.4	0.1	0.1	-0.1	-0.1	-0.6	-0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.0	0.4	-0.4	-0.4	-0.6	-0.3
Std. dev. time between licks in bursts	0.1	0.1	0.4	0.1	0.2	-0.2	-0.2	-0.7	-0.2
Total sessions with >9 infusions	3.9	4.8	6.0	-2.4	2.3	-2.3	-2.3	-1.5	-2.1
Short access day 1 total inactive lever presses	0.9	1.2	2.8	0.5	-1.1	1.1	1.1	1.7	0.9
Short access day 10 total inactive lever presses	2.1	5.2	5.9	2.4	-2.4	2.4	2.4	1.8	2.1
Short access day 1 total infusions	0.9	1.2	2.0	-1.4	1.1	-1.1	-1.1	-0.5	-1.0
Short access day 10 total infusions	3.4	4.4	6.1	-2.5	2.2	-2.2	-2.2	-1.3	-2.0
Short access total infusions	3.7	4.8	6.4	-2.5	2.3	-2.3	-2.3	-1.5	-2.1
Short access day 1 locomotion	0.1	0.1	0.4	-0.5	0.1	-0.1	-0.1	0.6	-0.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.1	0.4	-0.0
Short access total locomotion	1.8	2.2	3.5	-1.9	1.5	-1.5	-1.5	-0.6	-1.4
One hour access (0.3 mA shock)	0.3	0.4	1.2	-1.1	0.4	-0.4	-0.4	0.6	-0.5
Compulsive drug intake	0.2	0.2	0.4	-0.6	0.5	-0.5	-0.5	-0.0	-0.4
One hour access (shock baseline)	0.3	0.5	1.3	-1.1	0.6	-0.6	-0.6	0.1	-0.7
Social response proportion	2.3	2.6	4.1	-1.1	1.6	-1.6	-1.6	-2.0	-1.6
Social responses	0.0	0.1	0.1	0.3	-0.2	0.2	0.2	0.2	0.3
Social time	3.4	4.6	10.2	-1.1	2.1	-2.1	-2.1	-3.2	-1.6
Soleus weight	11.1	32.6	36.4	6.0	-6.0	6.0	6.0	4.8	5.4
Bone: stiffness	0.0	0.1	0.2	-0.1	0.4	-0.3	-0.3	-0.2	-0.1
Tibialis anterior weight	0.7	2.5	8.7	0.1	-1.3	1.3	1.3	2.9	0.9
Time to tail flick, vehicle, before self-admin	1.4	1.4	3.3	-0.6	1.1	-1.1	-1.1	-1.8	-1.0
Time to tail flick, vehicle, after self-admin	1.5	2.0	2.4	-1.2	1.5	-1.5	-1.5	-1.6	-1.3
Time to tail flick, test, before self-admin	2.0	2.1	3.3	1.8	-1.5	1.5	1.5	0.8	1.4
Time to tail flick, test, after self-admin	3.6	3.7	4.3	2.0	-2.1	2.1	2.1	1.5	1.8
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	0.7	-0.8	0.8	-0.8	-0.8	-0.8	-0.8
Delta time to tail flick, test, before/after SA	0.9	1.0	1.1	0.8	-1.1	1.1	1.1	1.0	0.9
Tibia length	4.0	11.0	12.5	-3.2	3.5	-3.4	-3.4	-2.8	-3.5
Ambulatory time before self-admin	1.0	1.6	1.7	1.2	-1.3	1.3	1.3	1.3	1.2
Ambulatory time after self-admin	0.2	0.3	0.9	0.1	-0.5	0.5	0.5	0.9	0.3
Bone: tissue strength	0.6	0.6	2.8	0.5	0.4	-0.3	-0.3	-1.7	0.2
Total heroin consumption	5.6	6.5	8.7	2.0	-2.7	2.7	2.7	2.9	2.3
Bone: trabecular number	7.3	12.1	13.7	3.0	-3.7	3.6	3.6	3.5	3.5
Bone: trabecular spacing	3.8	5.0	6.0	-2.1	2.3	-2.2	-2.2	-2.2	-2.4
Bone: trabecular thickness	0.4	0.5	0.9	0.9	-1.0	0.8	0.8	0.4	0.1
Bone: trabecular tissue density	0.7	1.1	3.5	-0.3	0.9	-0.8	-0.8	-1.9	-1.0
Water consumed over 24 hours	0.2	0.2	0.5	-0.7	0.2	-0.2	-0.2	0.6	-0.7
Number of responses in last shaping day	0.4	0.4	1.3	0.1	-0.5	0.5	0.5	1.1	0.5