Hub : Genes

Dnajc19

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Dnajc19	0.06	0.04	4.5e-05	0.03	0.02	0.02	0.02	5.6e-04	2.6e-03	9.4e-04	2.1e-03
2	Liver	gene expression	Dnajc19	0.08	0.04	1.5e-07	0.04	0.04	0.04	0.04	1.8e-05	4.1e-05	6.3e-05	8.5e-05
3	Adipose	mRNA stability	Dnajc19	0.04	0.02	1.4e-03	0.01	0.02	0.01	0.01	2.8e-02	3.9e-03	1.4e-02	6.7e-03
4	Adipose	gene expression	Dnajc19	0.04	0.02	4.7e-03	-0	0	-0	0	6.0e-01	7.4e-02	5.4e-01	3.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	3.7	6.2	7.0	-2.7	-2.6	2.5	2.1
Area under the delay curve	1.0	1.1	1.4	-0.9	-1.1	1.2	0.9
BMI with tail	0.6	1.8	3.1	-1.8	-1.6	0.8	1.1
BMI without tail	2.1	4.3	5.9	-2.4	-2.1	1.9	1.8
Body weight	0.0	0.1	0.2	-0.4	-0.1	-0.4	-0.2
Weight adjusted by age	1.2	1.4	1.7	1.3	1.2	-1.1	-1.1
Bone surface	0.2	0.4	0.4	-0.6	-0.6	0.6	0.6
Bone volume	0.5	0.8	1.0	-1.0	-0.9	1.0	0.6
Breakpoint value in progressive ratio session	3.1	3.4	5.1	-2.3	-1.8	1.4	1.8
Number of licking bursts	1.0	1.2	1.6	-1.3	-1.3	0.8	0.9
Context. condit. distance diff. score	3.4	4.2	5.4	-2.2	-2.1	2.3	1.3
Locomotion velocity, session 1	1.0	1.1	2.0	0.8	1.0	-1.4	-0.7
Locomotion distance, session 1	0.3	0.4	1.1	0.4	0.5	-1.0	-0.2
Locomotion velocity, session 2	2.9	3.3	5.3	1.5	1.6	-2.3	-1.8
Locomotion distance, session 2	0.9	1.3	2.4	0.9	1.0	-1.5	-1.0
Locomotion velocity, session 3	0.0	0.0	0.1	-0.3	-0.0	-0.1	0.2
Locomotion distance, session 3	0.3	0.3	0.5	0.4	0.5	-0.7	-0.5
Stereotopy head waving bouts, day 3	0.1	0.1	0.2	0.3	0.3	-0.4	-0.2
Stereotopy head waving duration, day 3	0.6	0.7	1.0	-0.9	-0.8	0.7	1.0
Locomotion velocity, session 7	0.9	1.0	2.0	0.8	0.9	-1.4	-0.8
Locomotion distance, session 7	1.0	1.3	1.9	1.0	0.9	-1.2	-1.4
Stereotopy head waving bouts, day 7	0.9	1.0	1.7	-1.3	-1.1	0.7	0.8
Stereotopy head waving duration, day 7	1.2	1.4	2.1	-1.4	-1.3	0.9	1.1
Locomotion velocity, session 8	1.9	2.3	3.0	-1.7	-1.6	1.4	1.3
Locomotion distance, session 8	0.5	0.7	1.0	-1.0	-1.0	0.9	0.4
Degree of sensitization distance	1.1	1.1	1.8	1.1	0.9	-0.8	-1.3
Degree of sensitization stereotypy	1.6	1.7	2.4	-1.6	-1.4	1.1	1.2
Conditioned locomotion	0.1	0.1	0.3	-0.0	-0.0	0.5	-0.2
Cocaine response after cond. corrected	0.1	0.1	0.4	0.0	0.2	0.6	-0.1
Cocaine response after cond. not corrected	0.2	0.2	0.4	0.6	0.6	0.2	-0.1
Cocaine response before conditioning	0.1	0.2	0.6	0.1	0.0	-0.1	0.8
Saline control response	0.3	0.4	0.7	0.8	0.8	-0.6	-0.2
Bone: connectivity density	2.1	3.3	3.7	-1.9	-1.9	1.7	1.7
Bone: cortical apparent density	0.0	0.1	0.1	0.0	-0.2	0.2	-0.4
Bone: cortical area	0.2	0.2	0.4	-0.5	-0.3	0.6	0.4
Bone: cortical porosity	0.6	0.7	2.2	-0.5	-0.3	0.5	1.5
Bone: cortical porosity	0.8	0.9	2.7	-0.6	-0.4	0.6	1.6
Bone: cortical thickness	0.6	0.9	1.3	-0.9	-0.6	1.1	1.1
Bone: cortical thickness	0.2	0.2	0.6	0.2	0.4	-0.8	-0.4
Bone: cortical tissue density	0.1	0.1	0.2	0.0	-0.3	0.2	-0.4
Condit. Reinf. active minus inactive responses	1.7	1.9	2.3	1.3	1.5	-1.5	-1.2
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.0	1.0	1.4	-1.1	-1.1
Condit. Reinf. active responses	0.9	1.1	2.1	0.9	1.0	-1.4	-0.7
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.1	-0.4	-0.4	0.6
Incentive salience index mean	1.8	2.2	2.5	1.5	1.6	-1.6	-1.3
Condit. Reinf. lever presses	0.5	0.6	1.0	0.9	0.8	-1.0	-0.4
Condit. Reinf. active minus inactive responses	1.3	1.6	2.4	1.6	1.2	-1.3	-0.7
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.3	1.5	1.2	-1.0	-1.1
Condit. Reinf. active responses	2.7	3.7	4.8	2.2	1.9	-2.2	-1.3
Condit. Reinf. inactive responses	1.3	1.7	2.7	1.2	1.4	-1.6	-0.8
Condit. Reinf. lever presses	0.1	0.2	0.3	0.5	0.4	-0.5	-0.2
Condit. Reinf. lever reinforcers received	2.4	3.4	4.4	2.0	1.8	-2.1	-1.3
Conditioned reinforcement - actives	0.5	0.5	0.6	0.8	0.7	-0.7	-0.6
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0
Conditioned locomotion	0.7	0.8	1.8	0.7	0.7	-1.3	-0.7
Patch foraging indifference point 0 sec	1.0	1.5	2.1	-1.5	-1.4	1.1	0.8
Patch foraging indifference point AUC	1.3	1.5	2.4	-1.3	-1.2	0.6	1.6
Delay disc. indifference point, 0s delay	0.3	0.4	0.6	0.6	0.5	-0.8	-0.6
Delay disc. indifference point, 16s delay	1.4	1.4	1.6	-1.1	-1.3	1.3	1.1
Delay disc. indifference point, 2s delay	0.4	0.5	0.7	-0.6	-0.8	0.8	0.6
Delay disc. indifference point, 24s delay	1.0	1.0	1.5	-0.8	-1.1	1.2	0.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	-0.6	-0.4	0.3	0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.2	-0.4	0.6	0.2
Indifference point function ln k	1.2	1.7	3.0	1.3	1.3	-0.7	-1.7
Indifference point function log k	1.2	1.7	3.0	1.3	1.3	-0.7	-1.7
Patch foraging total patch changes 0 sec	1.0	1.7	2.2	-1.5	-1.4	1.2	1.0
Patch foraging total patch changes 12 sec	2.2	2.8	3.1	-1.7	-1.7	1.5	1.8
Patch foraging total patch changes 18 sec	1.2	1.5	2.5	-1.6	-1.2	1.0	1.2
Patch foraging total patch changes 24 sec	5.3	6.5	8.6	-2.9	-2.7	2.1	2.5
Patch foraging total patch changes 6 sec	5.2	7.8	8.7	-3.0	-2.7	2.6	2.9
Patch foraging time to switch 0 sec	0.1	0.1	0.2	0.3	0.2	0.1	-0.5
Patch foraging water rate 0 sec	0.7	1.1	1.1	-1.0	-1.0	1.0	1.0
Patch foraging water rate 12 sec	0.0	0.0	0.1	0.3	0.3	-0.0	0.0
Patch foraging water rate 18 sec	0.2	0.2	0.4	0.6	0.4	-0.5	-0.4
Patch foraging water rate 24 sec	1.4	1.9	2.7	-1.5	-1.6	1.2	1.1
Patch foraging water rate 6 sec	0.0	0.0	0.1	-0.1	-0.0	0.2	0.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	0.9	-0.9	-0.7	0.6	0.9
Distance traveled before self-admin	2.6	2.7	3.3	-1.7	-1.8	1.5	1.5
Distance traveled after self-admin	0.5	0.5	0.9	-0.9	-0.8	0.4	0.7
Extensor digitorum longus weight	0.1	0.5	0.7	-0.8	-0.8	-0.2	0.6
Bone: elastic displacement	0.1	0.1	0.2	-0.2	-0.0	0.4	0.0
Bone: elastic work	0.1	0.2	0.4	0.4	0.6	0.0	-0.5
Bone: endosteal estimation	0.6	1.3	1.8	1.0	0.8	-1.3	-1.2
Bone: endosteal perimeter	0.5	1.1	1.3	1.1	1.0	-1.2	-0.9
Epididymis fat weight	0.7	1.7	1.9	1.3	1.3	-1.4	-1.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.2	-0.3	-0.5	0.3	0.4
Delta time in open arm before/after self-admin	0.9	0.8	1.0	1.0	1.0	-0.8	-0.9
Diff in mean of infusions in LGA sessions	0.7	0.8	1.3	-1.2	-0.6	0.9	0.8
Delay discount exponential model param	1.2	1.3	1.6	1.0	1.2	-1.3	-1.0
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.2	0.3	-0.4	-0.2
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.4	-0.2	0.0	0.2
Bone: final force	0.1	0.1	0.3	0.3	0.3	-0.5	0.0
Bone: final moment	0.0	0.0	0.0	0.1	0.1	-0.2	0.2
Food consumed during 24 hour testing period	0.1	0.1	0.3	0.1	0.1	-0.3	-0.6
Glucose	1.5	2.2	2.9	1.7	1.6	-1.3	-1.4
Heart weight	0.5	0.7	1.1	-0.7	-0.7	0.8	1.0
Delay discount hyperbolic model param	0.8	0.9	1.2	0.8	1.0	-1.1	-0.9
Intermittent access intake day 1-15 change	0.5	0.5	0.7	-0.8	-0.8	0.5	0.7
Intermittent access intake escalation	0.2	0.2	0.2	-0.5	-0.5	0.3	0.4
Intermittent access intake escalation 2	0.2	0.2	0.3	0.3	0.3	-0.5	-0.3
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.0	0.1	0.2	0.0
Intermitt. access day 15 inactive lever presses	0.6	0.6	0.8	0.9	0.9	-0.7	-0.7
Intermitt. access escalation Index	0.1	0.1	0.2	0.3	0.4	-0.4	-0.3
Intermittent access day 1 total infusions	3.7	4.3	5.2	2.1	2.3	-2.0	-1.9
Intermittent access day 15 total infusions	0.6	0.7	1.1	0.7	0.8	-1.0	-0.7
Intermittent access terminal intake (last 3 days)	2.6	2.9	3.7	1.6	1.7	-1.9	-1.5
Intermittent access total infusions	2.4	2.7	3.5	1.6	1.7	-1.9	-1.4
Intermittent access day 1 locomotion	1.3	1.3	1.7	1.1	1.2	-1.3	-1.0
Intermittent access day 15 total locomotion	0.5	0.6	1.0	-1.0	-0.8	0.3	0.8
Intermittent access total locomotion	0.2	0.2	0.8	0.2	0.3	-0.9	-0.2
Intermittent access standard deviation	0.1	0.1	0.1	-0.3	-0.3	0.4	0.3
Left kidney weight	0.1	0.3	0.5	-0.6	-0.6	0.7	0.0
Right kidney weight	0.2	0.6	1.0	-0.9	-1.0	0.7	0.4
Cocaine induced anxiety	0.5	0.6	1.1	0.7	0.7	-1.1	-0.6
Post-drug Anxiety	1.8	2.0	2.6	1.4	1.4	-1.6	-1.2
Baseline Anxiety	0.4	0.4	0.7	-0.6	-0.6	0.8	0.5
Tail length	0.1	0.4	0.8	-0.6	-0.4	0.9	0.4
Length with tail	0.1	0.4	0.5	0.7	0.7	-0.4	-0.7
Length without tail	1.6	3.4	3.8	1.8	1.8	-1.9	-1.9
Times rat made contact with spout	1.5	1.8	2.5	1.3	1.2	-1.3	-1.6
Lifetime Intake	3.0	3.4	4.1	1.8	1.9	-2.0	-1.6
Liver weight, left	2.4	3.8	5.4	1.7	1.7	-2.0	-2.3
Liver weight, right	0.2	0.3	0.4	0.6	0.6	-0.5	-0.6
Locomotor activity	1.7	2.7	3.9	2.0	1.9	-1.5	-0.9
Locomotor testing distance	0.8	1.3	1.8	1.3	1.3	-1.3	-0.2
Locomotor testing rearing	0.1	0.1	0.1	0.3	0.4	-0.2	0.3
Locomotion in novel chamber	0.5	0.6	1.2	0.7	0.6	-1.1	-0.6
Locomotion in novel chamber post-restriction	0.2	0.2	0.3	-0.3	-0.4	0.5	0.6
Fecal boli incidents, locomotor time 1	1.4	1.6	1.9	1.4	1.3	-0.9	-1.4
Change in fecal boli incidents, locomotor task	0.6	0.6	0.7	-0.8	-0.9	0.4	0.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.4	0.2	-0.2	-0.2
Bouts of movement, locomotor time 1	0.0	0.0	0.0	0.1	0.2	0.1	-0.1
Total resting periods, locomotor time 1	0.0	0.1	0.1	0.2	0.3	0.2	-0.2
Rest time, locomotor task time 1	1.3	1.4	2.0	1.4	1.1	-1.1	-1.2
Distance moved, locomotor task time 1	0.8	0.9	1.7	-1.3	-0.8	0.6	0.9
Vertical activity count, locomotor time 1	1.3	1.3	1.9	-1.4	-1.1	1.0	1.0
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.5	0.2	-0.4	-0.4
Bouts of movement, locomotor time 2	0.7	0.7	1.5	-0.7	-0.5	1.2	0.8
Total resting periods, locomotor time 2	0.4	0.4	1.0	-0.4	-0.2	1.0	0.6
Rest time, locomotor task time 2	0.0	0.0	0.1	0.2	-0.0	0.1	0.0
Distance moved, locomotor task time 2	0.1	0.1	0.5	-0.0	0.3	-0.7	-0.1
Vertical activity count, locomotor time 2	0.8	0.9	1.7	0.9	0.7	-1.3	-0.8
Light reinforcement 1	0.1	0.2	0.6	0.7	0.6	-0.2	-0.1
Light reinforcement 2	0.0	0.1	0.2	0.2	0.2	-0.1	-0.4
Bone: marrow area	0.5	1.1	1.5	0.9	0.7	-1.2	-1.2
Bone: maximum diameter	0.1	0.1	0.2	-0.4	-0.2	0.4	0.3
Bone: maximum force	0.1	0.2	0.4	0.6	0.5	-0.4	-0.3
Bone: maximum moment	0.1	0.1	0.2	0.5	0.4	-0.1	-0.2
Mean time between licks in bursts	0.6	0.8	1.1	1.0	1.0	-0.3	-1.0
Mean num. licks in bursts	1.9	2.3	2.9	1.7	1.7	-1.3	-1.4
Cd content in liver	1.0	1.1	1.7	1.1	1.3	-1.0	-0.7
Co content in liver	0.4	0.5	0.7	0.7	0.7	-0.9	-0.6
Cu content in liver	0.2	0.3	0.4	0.3	0.7	-0.3	-0.6
Fe content in liver	0.5	0.6	0.9	0.9	0.9	-0.6	-0.5
K content in liver	1.3	1.3	1.7	-1.1	-1.1	1.3	0.9
Mg content in liver	0.8	0.8	1.5	-0.8	-0.7	1.2	0.6
Mn content in liver	0.4	0.5	1.2	-0.5	-0.5	1.1	0.5
Na content in liver	1.1	1.1	1.6	-1.1	-1.2	0.9	0.9
Rb content in liver	0.5	0.6	1.0	-0.9	-0.4	0.7	1.0
Se content in liver	1.0	1.2	1.5	1.2	1.2	-1.2	-0.7
Sr content in liver	0.0	0.0	0.1	0.1	-0.1	-0.3	0.1
Zn content in liver	0.1	0.1	0.3	-0.4	-0.2	0.5	-0.2
Bone: minimum diameter	0.3	0.6	0.8	0.9	0.8	-0.5	-0.8
Time in familiar zone, hab. session 1	0.7	0.7	0.8	0.9	0.7	-0.8	-0.9
Time in novel zone, hab. session 1	3.9	3.8	4.7	-2.0	-1.8	1.9	2.2
Total zone transitions, hab. session 1	0.5	0.7	1.4	-0.8	-0.8	0.5	1.2
Total locomotion distance, hab. session 1	2.9	4.1	5.9	-1.9	-2.0	1.6	2.4
Locomotion velocity, hab. session 1	2.5	3.5	5.2	-1.8	-1.9	1.4	2.3
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.1	0.1	0.4	0.5
Time in novel zone, hab. session 2	0.7	0.7	1.2	-1.1	-1.0	0.6	0.5
Total zone transitions, hab. session 2	0.0	0.1	0.1	0.2	0.2	-0.4	0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.4	-0.1	-0.2	-0.1	0.6
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.2	-0.0	-0.3	0.4
Novel to familiar place preference ratio	8.0	8.2	9.0	-2.9	-2.9	3.0	2.7
Novelty place preference	10.4	10.6	11.3	-3.3	-3.3	3.4	3.1
Time in novel zone, NPP test	11.4	11.8	12.5	-3.5	-3.5	3.5	3.2
Total zone transitions, NPP test	1.1	1.5	2.8	1.1	1.2	-1.7	-0.8
Total locomotion distance, NPP test	0.4	0.6	1.2	0.8	0.7	-1.1	-0.3
Locomotion velocity, NPP test	0.8	1.1	2.0	1.1	1.0	-1.4	-0.5
Intraocular pressure	0.9	1.3	1.7	1.3	1.2	-1.0	-1.0
Delta distance traveled before/after self-admin	1.4	1.5	1.8	1.2	1.3	-1.3	-1.1
Delta ambulatory time before/after self-admin	1.0	1.1	1.4	0.9	1.1	-1.2	-0.9
Parametrial fat weight	0.3	0.7	1.2	0.6	0.5	-1.0	-1.1
Pavlov. Cond. lever latency	1.5	2.0	2.7	-1.6	-1.2	1.4	1.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.2	-0.1	-0.2
Pavlov. Cond. change in total contacts	0.4	0.4	0.7	0.8	0.6	-0.6	-0.5
Pavlov. Cond. index score	0.8	1.0	1.4	1.1	0.6	-1.2	-0.9
Pavlov. Cond. latency score	1.2	1.5	2.0	1.4	0.9	-1.4	-1.1
Pavlov. Cond. lever contacts	1.9	2.3	2.8	1.7	1.3	-1.6	-1.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.1	0.4	0.3	0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.3	0.6	-0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.0	0.9	0.4	-1.0	-0.8
Pavlov. Cond. response bias	0.1	0.2	0.3	0.3	-0.1	-0.5	-0.5
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.4	0.5	-0.2	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.2	-0.2	0.3	-0.4
Pavlov. Cond. change in total contacts	0.5	0.7	1.2	0.8	0.8	-1.1	-0.3
Pavlov. Cond. index score	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.1
Pavlov. Cond. lever contacts	0.6	0.8	1.3	-0.9	-0.9	0.6	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.5	0.5	-0.2	0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	0.2	0.3	-0.6	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	-0.1	-0.3	-0.1
Pavlov. Cond. response bias	0.5	0.6	0.9	-0.8	-0.8	0.6	1.0
Time in closed arm before self-admin	0.3	0.3	0.5	-0.7	-0.3	0.6	0.5
Time in closed arm after self-admin	0.1	0.2	0.3	-0.4	-0.2	0.5	0.3
Time in open arm before self-admin	0.7	0.7	1.2	-0.8	-1.1	0.6	0.8
Time in open arm after self-admin	0.1	0.1	0.1	0.3	0.1	-0.3	-0.2
Bone: periosteal estimation	0.1	0.3	0.4	0.4	0.4	-0.6	-0.6
Bone: periosteal perimeter	0.0	0.1	0.1	0.3	0.3	-0.0	0.2
Bone: post-yield work	1.8	2.5	3.0	1.7	1.4	-1.4	-1.7
Progressive ratio test 1 active lever presses	1.3	1.4	2.1	1.0	1.3	-1.4	-0.9
Progressive ratio test 1 breakpoint	1.5	1.6	2.4	1.1	1.3	-1.6	-1.0
Progressive ratio test 1 inactive lever presses	1.2	1.3	1.5	1.1	1.2	-1.2	-1.0
Progressive ratio test 2 active lever presses	1.2	1.2	2.1	1.0	1.1	-1.5	-0.9
Progressive ratio test 2 breakpoint	0.7	0.8	1.6	0.7	0.8	-1.3	-0.7
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.0	0.8	0.9	-1.0	-0.7
Incentive Sensitization - Responses	0.2	0.2	0.7	0.2	0.2	-0.8	-0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.9	0.3	0.4	-1.0	-0.4
Sum of active levers in priming session hrs 5-6	2.9	2.8	3.7	1.5	1.7	-1.9	-1.5
Progressive ratio	0.2	0.2	0.3	0.6	0.4	-0.5	-0.2
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	-0.3	0.5	0.3
Seeking ratio, punishment vs. effort	0.6	0.7	1.0	-1.0	-0.8	0.9	0.6
Retroperitoneal fat weight	0.4	1.3	1.7	1.2	1.0	-1.3	-1.1
Reaction time number correct	2.9	4.3	5.6	2.0	2.2	-2.4	-1.6
Reaction time mean minus median	0.0	0.0	0.1	-0.0	0.1	0.0	-0.3
Reaction time mean minus median AUC	0.2	0.2	0.4	-0.6	-0.4	0.5	0.2
Reaction time num false alarms	0.1	0.2	0.5	-0.2	-0.3	0.0	0.7
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.1	-0.1	-0.2	0.5
Reaction time trials correct on left	2.9	4.3	5.6	2.0	2.2	-2.4	-1.6
Reaction time trials on left	3.1	4.4	5.7	2.1	2.2	-2.4	-1.6
Reaction time mean	1.3	1.8	2.3	1.3	1.5	-1.2	-1.3
Reaction time mean AUC	0.9	1.3	1.8	1.1	1.3	-1.0	-1.0
Median of all reaction times	1.3	1.7	2.3	1.3	1.5	-1.2	-1.1
Reaction time omissions	0.3	0.3	0.5	0.6	0.7	-0.2	-0.7
Reaction time false alarm rate	1.2	1.6	2.1	-1.2	-1.3	1.1	1.5
Reaction time premature initiation rate	1.4	1.9	3.1	-1.1	-1.2	1.8	1.3
Reaction time premature initiations	0.0	0.0	0.1	0.2	0.2	0.2	0.2
Std. dev. reaction times	0.1	0.1	0.3	0.1	0.4	-0.2	-0.5
Reaction time trials completed	3.1	4.4	5.7	2.1	2.2	-2.4	-1.6
Reaction time trials AUC	2.9	4.1	5.2	2.0	2.2	-2.3	-1.5
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.2	0.4	-0.1	0.2
Run reversals in cocaine runway, males	0.6	0.6	0.8	0.9	0.6	-0.9	-0.6
Latency to leave start box in cocaine runway	0.1	0.1	0.1	0.3	0.3	-0.0	-0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.3	0.3	0.0	-0.3
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.0	-0.1	0.3	-0.0
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.3	0.4	-0.0	-0.2
Total sessions with >9 infusions	1.3	1.4	1.7	1.3	1.3	-1.1	-1.1
Short access day 1 total inactive lever presses	0.4	0.5	0.7	-0.9	-0.8	0.2	0.7
Short access day 10 total inactive lever presses	2.4	2.7	2.9	-1.7	-1.6	1.7	1.5
Short access day 1 total infusions	0.7	0.7	1.1	0.8	0.8	-1.1	-0.7
Short access day 10 total infusions	2.0	2.2	2.4	1.5	1.5	-1.5	-1.3
Short access total infusions	2.7	3.0	3.3	1.8	1.8	-1.8	-1.6
Short access day 1 locomotion	0.4	0.4	0.6	-0.7	-0.8	0.2	0.6
Short access day 10 total locomotion	0.3	0.4	0.5	-0.7	-0.7	0.5	0.6
Short access total locomotion	0.8	0.8	1.1	0.9	0.9	-1.1	-0.8
One hour access (0.3 mA shock)	0.7	0.8	1.3	0.8	0.9	-1.1	-0.7
Compulsive drug intake	0.6	0.6	1.0	0.7	0.6	-1.0	-0.6
One hour access (shock baseline)	1.0	1.1	1.4	1.0	1.2	-1.1	-0.9
Social response proportion	2.2	2.4	2.8	1.7	1.6	-1.2	-1.6
Social responses	0.1	0.1	0.1	-0.2	-0.3	0.4	0.3
Social time	2.2	3.0	4.4	2.1	2.1	-1.0	-1.4
Soleus weight	11.5	33.7	36.1	-6.0	-6.0	5.9	5.4
Bone: stiffness	0.0	0.0	0.1	0.3	0.2	0.1	0.0
Tibialis anterior weight	0.3	1.0	2.0	-1.4	-1.1	0.0	0.9
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.7	0.8	0.8	-0.3	-0.7
Time to tail flick, vehicle, after self-admin	1.7	1.9	2.2	1.5	1.5	-1.2	-1.3
Time to tail flick, test, before self-admin	2.5	2.5	3.4	-1.5	-1.5	1.8	1.3
Time to tail flick, test, after self-admin	3.6	3.7	4.5	-2.0	-1.8	2.1	1.7
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.3	1.1	1.1	-0.9	-1.0
Delta time to tail flick, test, before/after SA	1.1	1.0	1.2	-1.1	-1.0	1.0	0.9
Tibia length	4.1	11.6	12.6	3.5	3.4	-3.3	-3.4
Ambulatory time before self-admin	2.1	2.2	2.5	-1.5	-1.6	1.4	1.4
Ambulatory time after self-admin	0.3	0.4	0.6	-0.8	-0.6	0.4	0.6
Bone: tissue strength	0.2	0.2	0.5	0.3	0.2	0.7	0.3
Total heroin consumption	5.0	5.9	7.6	-2.7	-2.5	2.1	2.3
Bone: trabecular number	6.5	10.2	11.1	-3.3	-3.3	3.0	3.2
Bone: trabecular spacing	3.7	4.8	5.3	2.1	2.3	-2.1	-2.3
Bone: trabecular thickness	0.4	0.5	0.8	-0.9	-0.7	0.8	-0.0
Bone: trabecular tissue density	0.4	0.6	1.0	1.0	0.9	-0.2	-0.9
Water consumed over 24 hours	0.1	0.2	0.4	0.1	0.0	-0.5	-0.6
Number of responses in last shaping day	0.6	0.7	1.0	-0.9	-1.0	0.6	0.8