Hub : Genes

Dmpk

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio XM_063261333.1 0.02 0.03 6.7e-03 0.02 0.02 0.02 0.02 1.2e-03 5.3e-03 1.2e-03 5.7e-03
2 Adipose intron excision ratio chr1_87862554_87863196 0.1 0.06 2.4e-13 0.11 0.1 0.1 0.1 7.5e-12 9.8e-12 3.8e-11 1.5e-11
3 Brain isoform ratio XM_063261313.1 0.04 0.04 2.0e-04 0.03 0.02 0.02 0.02 1.1e-03 2.5e-03 3.7e-03 5.8e-03
4 Adipose isoform ratio NM_001415848.1 0.09 0.07 1.2e-09 0.08 0.08 0.08 0.08 1.5e-09 2.7e-09 2.4e-09 2.2e-09
5 BLA intron excision ratio chr1_87862569_87863196 0.05 0.05 7.5e-03 0 0.02 0 0.01 2.0e-01 2.0e-02 1.9e-01 8.9e-02
6 Adipose intron excision ratio chr1_87862569_87863196 0.07 0.05 2.8e-08 0.06 0.07 0.06 0.06 1.4e-07 7.0e-08 9.7e-08 1.4e-07
7 PL intron excision ratio chr1_87862554_87863196 0.03 0.03 3.5e-04 0.02 0.03 0.02 0.02 5.5e-03 3.9e-04 3.5e-03 2.5e-03
8 NAcc intron excision ratio chr1_87862569_87863196 0.04 0.04 2.4e-05 0.02 0.02 0.02 0.02 1.2e-04 2.7e-04 5.1e-04 2.8e-04
9 Adipose isoform ratio NM_001415849.1 0.03 0.03 5.4e-04 0.02 0.02 0.02 0.02 1.2e-03 1.2e-03 5.3e-03 2.1e-03
10 Adipose mRNA stability Dmpk 0.12 0.08 5.5e-14 0.12 0.12 0.12 0.12 6.0e-13 1.7e-13 7.4e-13 5.0e-13
11 Adipose isoform ratio NM_001415847.1 0.03 0.02 1.8e-03 0.02 0.02 0.02 0.02 1.3e-03 1.0e-03 2.9e-03 2.1e-03
12 Adipose gene expression Dmpk 0.17 0.1 0.0e+00 0.17 0.17 0.17 0.17 1.8e-18 7.3e-19 3.0e-18 1.1e-18
13 pVTA intron excision ratio chr1_87862554_87863196 0.06 0.05 2.8e-04 0.03 0.03 0.02 0.03 3.9e-03 1.6e-03 5.0e-03 3.2e-03
14 Brain intron excision ratio chr1_87862554_87863196 0.14 0.1 9.8e-15 0.16 0.16 0.16 0.16 2.4e-14 1.6e-14 2.4e-14 2.2e-14
15 Adipose alternative polyA XM_063261309.1 0.04 0.06 2.0e-03 0.02 0.02 0.01 0.02 8.6e-04 1.3e-03 1.7e-02 9.9e-04
16 Adipose alternative polyA XM_063261309.1 0.05 0.07 1.9e-03 0.02 0.02 0.01 0.02 8.8e-04 1.9e-03 1.4e-02 1.4e-03
17 Adipose isoform ratio NM_001372064.1 0.06 0.05 3.1e-07 0.05 0.04 0.04 0.04 7.7e-06 1.0e-05 5.6e-05 2.0e-05
18 Brain intron excision ratio chr1_87862569_87863196 0.13 0.11 1.6e-09 0.07 0.07 0.06 0.07 2.7e-07 2.2e-07 2.9e-06 6.4e-07
19 PL intron excision ratio chr1_87862569_87863196 0.09 0.11 2.2e-05 0.02 0.03 0.03 0.03 4.6e-03 1.1e-04 7.6e-04 7.2e-04
20 NAcc intron excision ratio chr1_87862554_87863196 0.05 0.04 3.3e-09 0.07 0.05 0.06 0.06 2.8e-10 5.7e-08 7.0e-10 6.5e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.00.00.1-0.1-0.1-0.2-0.20.00.0-0.00.1-0.0-0.00.0-0.0-0.00.10.20.2-0.2-0.1-0.10.0
Area under the delay curve1.41.62.21.21.01.31.3-1.3-1.31.3-1.11.31.3-1.31.31.31.41.51.5-1.3-1.4-1.40.0
BMI with tail0.62.24.0-2.0-2.0-1.7-1.91.51.5-1.51.5-1.5-1.51.5-1.4-1.4-1.4-1.3-1.31.31.21.20.0
BMI without tail0.92.75.8-2.2-2.4-1.9-2.01.71.7-1.61.8-1.6-1.71.6-1.5-1.5-1.5-1.3-1.31.31.21.20.0
Body weight1.35.810.3-3.1-3.2-2.7-2.82.52.5-2.42.7-2.4-2.52.4-2.3-2.3-2.3-2.2-2.22.12.02.00.0
Weight adjusted by age0.00.00.2-0.3-0.1-0.4-0.40.10.1-0.10.5-0.1-0.10.1-0.1-0.1-0.10.00.00.1-0.0-0.00.0
Bone surface0.20.40.8-0.8-0.9-0.8-0.80.70.7-0.70.6-0.7-0.70.7-0.7-0.6-0.6-0.6-0.60.50.50.50.0
Bone volume0.20.30.5-0.7-0.7-0.7-0.70.60.6-0.60.6-0.6-0.60.5-0.6-0.5-0.5-0.4-0.40.40.40.40.0
Breakpoint value in progressive ratio session2.12.63.51.71.81.71.9-1.7-1.71.7-1.31.71.7-1.71.71.71.61.61.6-1.5-1.6-1.60.0
Number of licking bursts2.43.94.4-2.0-1.9-2.0-2.02.02.0-2.02.1-2.0-2.02.0-2.0-2.0-2.1-2.1-2.12.12.12.10.0
Context. condit. distance diff. score0.10.10.2-0.0-0.1-0.1-0.10.30.3-0.30.2-0.3-0.30.3-0.3-0.3-0.4-0.3-0.30.30.40.40.0
Locomotion velocity, session 10.10.10.30.40.60.20.2-0.3-0.30.3-0.20.30.3-0.30.30.20.20.30.3-0.3-0.1-0.10.0
Locomotion distance, session 10.00.00.00.10.2-0.0-0.00.00.0-0.1-0.0-0.00.00.1-0.1-0.1-0.1-0.1-0.10.10.10.20.0
Locomotion velocity, session 21.41.62.1-1.5-1.5-1.3-1.31.31.3-1.31.3-1.3-1.31.3-1.3-1.3-1.3-1.2-1.21.31.21.20.0
Locomotion distance, session 20.20.30.4-0.6-0.6-0.6-0.60.60.5-0.60.5-0.6-0.50.6-0.6-0.6-0.5-0.5-0.50.50.50.50.0
Locomotion velocity, session 30.20.30.5-0.6-0.7-0.5-0.50.50.5-0.50.5-0.5-0.50.5-0.5-0.5-0.5-0.5-0.50.50.40.40.0
Locomotion distance, session 30.70.81.00.90.71.01.0-0.9-0.90.9-1.00.90.9-0.90.90.91.00.90.9-0.9-1.0-1.00.0
Stereotopy head waving bouts, day 31.01.21.4-1.1-1.0-1.1-1.11.11.1-1.11.1-1.1-1.11.1-1.1-1.1-1.2-1.1-1.11.11.21.20.0
Stereotopy head waving duration, day 31.01.21.6-0.9-0.9-1.0-1.01.11.1-1.11.0-1.1-1.11.1-1.1-1.1-1.2-1.2-1.21.21.21.30.0
Locomotion velocity, session 70.20.20.50.70.50.60.6-0.5-0.50.5-0.50.50.5-0.50.50.50.50.40.4-0.4-0.4-0.40.0
Locomotion distance, session 70.00.00.10.1-0.3-0.0-0.00.10.1-0.10.1-0.1-0.10.1-0.1-0.1-0.1-0.2-0.20.20.10.10.0
Stereotopy head waving bouts, day 71.01.11.4-1.1-0.8-1.1-1.11.11.1-1.11.1-1.1-1.11.1-1.1-1.1-1.1-1.0-1.01.01.21.20.0
Stereotopy head waving duration, day 70.81.01.2-1.1-0.8-1.1-1.11.01.0-1.01.0-1.0-1.01.0-1.0-1.0-1.0-0.9-0.91.01.11.10.0
Locomotion velocity, session 80.00.00.10.30.10.20.2-0.1-0.10.1-0.20.10.1-0.10.10.10.00.00.0-0.00.00.00.0
Locomotion distance, session 80.00.00.00.1-0.00.10.10.00.0-0.0-0.1-0.0-0.00.0-0.1-0.0-0.00.00.0-0.00.00.00.0
Degree of sensitization distance0.50.50.7-0.6-0.7-0.7-0.70.70.7-0.70.7-0.7-0.70.8-0.7-0.8-0.8-0.8-0.80.80.80.80.0
Degree of sensitization stereotypy1.11.11.5-1.2-0.9-1.2-1.21.11.1-1.11.2-1.1-1.11.1-1.1-1.1-1.1-1.0-1.01.01.11.10.0
Conditioned locomotion0.00.00.10.10.30.20.2-0.2-0.20.2-0.20.20.2-0.20.20.20.20.20.2-0.2-0.2-0.20.0
Cocaine response after cond. corrected0.50.50.7-0.7-0.6-0.6-0.60.80.8-0.80.7-0.8-0.80.8-0.8-0.8-0.8-0.8-0.80.80.80.80.0
Cocaine response after cond. not corrected1.21.51.6-1.2-1.1-1.1-1.11.21.2-1.31.2-1.2-1.21.3-1.3-1.3-1.3-1.3-1.31.31.31.30.0
Cocaine response before conditioning1.61.92.4-1.5-1.5-1.5-1.51.41.4-1.41.5-1.4-1.41.4-1.4-1.4-1.4-1.3-1.31.31.31.30.0
Saline control response2.02.73.0-1.7-1.6-1.7-1.71.71.7-1.71.5-1.7-1.71.7-1.7-1.7-1.7-1.7-1.71.71.71.70.0
Bone: connectivity density0.00.10.20.0-0.1-0.1-0.0-0.2-0.20.2-0.10.20.2-0.20.20.20.30.40.4-0.4-0.4-0.40.0
Bone: cortical apparent density0.10.10.30.20.20.10.0-0.3-0.30.3-0.10.30.2-0.30.30.30.30.50.5-0.5-0.3-0.30.0
Bone: cortical area1.52.32.7-1.6-1.6-1.4-1.41.61.6-1.61.4-1.6-1.61.6-1.6-1.6-1.6-1.6-1.61.61.51.50.0
Bone: cortical porosity0.10.10.40.30.30.60.7-0.4-0.40.4-0.50.40.4-0.40.40.40.30.30.3-0.2-0.3-0.30.0
Bone: cortical porosity0.00.00.1-0.1-0.10.20.20.00.0-0.0-0.1-0.0-0.10.0-0.0-0.0-0.1-0.1-0.10.10.10.00.0
Bone: cortical thickness0.50.91.0-1.0-1.0-0.9-0.91.01.0-1.00.9-1.0-1.01.0-1.0-1.0-1.0-1.0-1.01.01.01.00.0
Bone: cortical thickness1.31.61.9-1.4-1.3-1.3-1.21.31.3-1.31.1-1.3-1.31.3-1.3-1.3-1.3-1.2-1.21.31.31.30.0
Bone: cortical tissue density0.10.20.40.30.30.20.1-0.4-0.40.4-0.20.40.4-0.40.40.40.40.60.6-0.6-0.5-0.50.0
Condit. Reinf. active minus inactive responses0.40.51.0-1.0-0.9-0.8-0.90.70.7-0.70.8-0.7-0.70.7-0.7-0.7-0.7-0.5-0.50.60.60.50.0
Condit. Reinf. active-inactive response ratio0.30.30.8-0.9-0.8-0.7-0.80.60.6-0.60.7-0.6-0.60.6-0.6-0.6-0.5-0.3-0.30.40.40.40.0
Condit. Reinf. active responses0.20.30.6-0.8-0.8-0.6-0.70.60.6-0.50.6-0.5-0.60.5-0.5-0.5-0.5-0.3-0.30.40.40.40.0
Condit. Reinf. inactive responses0.10.10.20.40.30.40.4-0.3-0.30.3-0.40.30.3-0.30.30.30.30.30.3-0.2-0.3-0.30.0
Incentive salience index mean0.30.41.0-1.0-0.9-0.8-0.80.60.6-0.60.8-0.6-0.70.6-0.6-0.6-0.5-0.4-0.40.40.40.40.0
Condit. Reinf. lever presses0.10.10.4-0.6-0.6-0.4-0.50.30.3-0.20.4-0.2-0.30.2-0.2-0.2-0.1-0.0-0.00.00.0-0.00.0
Condit. Reinf. active minus inactive responses0.00.10.1-0.2-0.1-0.1-0.20.20.3-0.30.3-0.2-0.20.3-0.2-0.3-0.3-0.2-0.20.30.30.30.0
Condit. Reinf. active-inactive response ratio0.30.30.5-0.3-0.3-0.4-0.40.50.6-0.60.5-0.6-0.50.6-0.6-0.6-0.6-0.6-0.60.70.70.70.0
Condit. Reinf. active responses0.10.10.20.30.40.40.3-0.3-0.30.3-0.20.30.3-0.30.30.30.30.40.4-0.3-0.3-0.30.0
Condit. Reinf. inactive responses0.60.80.90.70.80.90.8-0.9-0.90.9-0.90.90.9-0.90.90.90.91.01.0-0.9-0.9-0.90.0
Condit. Reinf. lever presses0.10.10.3-0.5-0.5-0.2-0.30.40.4-0.40.3-0.4-0.40.4-0.4-0.4-0.4-0.4-0.40.40.40.40.0
Condit. Reinf. lever reinforcers received0.10.10.20.30.40.50.4-0.4-0.40.4-0.30.40.4-0.30.40.30.30.40.4-0.3-0.3-0.30.0
Conditioned reinforcement - actives1.42.43.7-1.9-1.9-1.9-1.81.61.6-1.61.3-1.6-1.61.5-1.5-1.5-1.5-1.4-1.41.41.41.30.0
Conditioned reinforcement - inactives0.71.02.6-1.6-1.6-1.2-1.31.01.0-0.91.1-0.9-1.00.9-0.9-0.9-0.8-0.8-0.80.80.60.60.0
Conditioned locomotion2.12.74.1-1.5-1.4-2.0-1.91.71.7-1.71.6-1.7-1.61.7-1.7-1.7-1.7-1.7-1.71.71.81.80.0
Patch foraging indifference point 0 sec0.30.61.0-0.5-0.4-0.3-0.30.80.8-0.80.6-0.8-0.80.8-0.8-0.8-0.9-0.9-0.90.81.01.00.0
Patch foraging indifference point AUC3.55.07.2-2.6-2.6-2.7-2.72.32.2-2.22.5-2.2-2.22.2-2.2-2.2-2.2-2.2-2.22.12.02.00.0
Delay disc. indifference point, 0s delay1.01.11.60.80.70.90.9-1.1-1.11.1-0.81.11.0-1.11.11.11.11.21.2-1.2-1.2-1.30.0
Delay disc. indifference point, 16s delay1.01.11.51.00.61.01.0-1.0-1.01.0-1.11.01.0-1.01.01.11.11.21.2-1.2-1.2-1.20.0
Delay disc. indifference point, 2s delay2.83.14.11.61.31.51.5-1.8-1.81.8-1.61.81.8-1.91.91.91.92.02.0-1.8-2.0-2.00.0
Delay disc. indifference point, 24s delay0.00.00.10.20.00.20.20.10.1-0.1-0.1-0.1-0.10.2-0.2-0.2-0.2-0.0-0.00.20.20.20.0
Delay disc. indifference point, 4s delay0.00.00.1-0.1-0.1-0.1-0.10.00.0-0.00.3-0.0-0.0-0.00.00.00.00.10.10.1-0.0-0.00.0
Delay disc. indifference point, 8s delay1.51.72.01.41.31.31.3-1.4-1.41.4-1.21.41.4-1.41.41.41.41.31.3-1.3-1.4-1.40.0
Indifference point function ln k1.22.24.71.82.02.12.2-1.4-1.41.4-1.81.31.4-1.31.31.31.21.31.3-1.3-1.0-1.00.0
Indifference point function log k1.22.24.71.82.02.12.2-1.4-1.41.4-1.81.31.4-1.31.31.31.21.31.3-1.3-1.0-1.00.0
Patch foraging total patch changes 0 sec0.50.91.5-0.7-0.5-0.5-0.50.90.9-1.00.8-1.0-0.91.0-1.0-1.0-1.1-1.1-1.11.01.21.20.0
Patch foraging total patch changes 12 sec1.72.23.6-1.9-1.9-1.7-1.71.51.5-1.51.6-1.5-1.51.5-1.4-1.4-1.4-1.4-1.41.41.31.30.0
Patch foraging total patch changes 18 sec1.92.93.6-1.6-1.4-1.9-1.81.71.7-1.71.9-1.7-1.71.7-1.7-1.7-1.7-1.8-1.81.71.81.80.0
Patch foraging total patch changes 24 sec0.50.82.1-1.3-1.1-1.4-1.40.80.8-0.81.1-0.8-0.80.8-0.8-0.8-0.8-0.8-0.80.60.60.60.0
Patch foraging total patch changes 6 sec2.23.43.9-1.9-1.8-1.6-1.71.91.9-1.91.7-1.9-1.91.9-1.9-1.9-1.9-2.0-2.01.92.02.00.0
Patch foraging time to switch 0 sec2.24.55.22.22.11.91.9-2.2-2.22.2-2.02.22.2-2.22.22.22.22.32.3-2.2-2.3-2.30.0
Patch foraging water rate 0 sec2.65.46.4-2.5-2.3-2.1-2.12.42.4-2.42.2-2.4-2.42.4-2.4-2.4-2.4-2.4-2.42.42.52.50.0
Patch foraging water rate 12 sec0.10.20.3-0.5-0.3-0.3-0.20.50.4-0.50.3-0.5-0.40.5-0.5-0.5-0.4-0.4-0.40.40.50.50.0
Patch foraging water rate 18 sec0.10.10.3-0.6-0.4-0.3-0.20.40.4-0.40.1-0.4-0.40.4-0.4-0.4-0.4-0.4-0.40.40.40.40.0
Patch foraging water rate 24 sec0.40.60.9-0.7-0.4-0.5-0.50.80.8-0.80.7-0.8-0.70.8-0.8-0.8-0.8-0.8-0.80.90.90.90.0
Patch foraging water rate 6 sec0.60.91.5-1.2-1.0-1.0-1.01.01.0-1.00.9-1.0-0.91.0-1.0-1.0-0.9-0.9-0.90.90.90.90.0
Seeking ratio, delayed vs. immediate footshock1.92.32.81.61.71.51.6-1.5-1.51.5-1.41.51.5-1.51.51.51.51.51.5-1.6-1.5-1.50.0
Distance traveled before self-admin0.00.10.1-0.1-0.1-0.1-0.30.20.2-0.30.0-0.3-0.20.3-0.3-0.3-0.3-0.3-0.30.20.30.30.0
Distance traveled after self-admin0.20.20.60.50.50.60.5-0.5-0.50.5-0.80.50.5-0.50.50.50.50.40.4-0.4-0.4-0.40.0
Extensor digitorum longus weight1.97.49.4-2.9-3.0-3.1-2.82.82.8-2.82.9-2.8-2.82.7-2.8-2.7-2.7-2.8-2.82.72.62.60.0
Bone: elastic displacement0.80.91.20.90.80.80.9-1.0-1.01.0-0.61.00.9-1.01.01.01.01.11.1-1.0-1.0-1.00.0
Bone: elastic work0.00.10.2-0.4-0.5-0.3-0.20.20.2-0.20.3-0.2-0.30.2-0.2-0.2-0.2-0.1-0.10.10.10.10.0
Bone: endosteal estimation0.00.00.1-0.0-0.20.20.2-0.2-0.20.2-0.20.20.2-0.20.20.20.20.20.2-0.2-0.3-0.40.0
Bone: endosteal perimeter0.00.00.0-0.1-0.10.20.10.00.0-0.0-0.1-0.0-0.00.00.00.00.0-0.0-0.00.0-0.0-0.10.0
Epididymis fat weight0.20.60.90.50.50.60.6-0.8-0.80.8-0.70.80.7-0.80.80.80.80.90.9-0.9-0.9-0.90.0
Delta time in closed arm before/after self-admin0.30.30.91.00.80.90.8-0.5-0.50.4-0.70.40.5-0.40.40.40.40.40.4-0.4-0.2-0.20.0
Delta time in open arm before/after self-admin0.10.10.4-0.6-0.5-0.6-0.60.00.00.00.20.0-0.0-0.00.10.10.10.10.1-0.1-0.3-0.30.0
Diff in mean of infusions in LGA sessions1.21.51.91.31.41.11.0-1.3-1.31.3-0.91.31.3-1.31.31.31.31.21.2-1.2-1.2-1.20.0
Delay discount exponential model param1.11.21.6-1.1-0.8-1.1-1.11.11.1-1.10.9-1.1-1.11.1-1.1-1.1-1.1-1.3-1.31.11.21.20.0
Extinction: sum of active levers before priming0.00.00.10.20.20.30.3-0.2-0.20.2-0.00.20.2-0.20.20.20.20.10.10.0-0.2-0.20.0
Active lever presses in extinction session 60.10.10.5-0.7-0.6-0.3-0.20.40.4-0.30.5-0.3-0.40.3-0.3-0.3-0.3-0.3-0.30.40.20.20.0
Bone: final force0.40.61.0-0.9-1.0-0.8-0.80.80.8-0.80.8-0.8-0.80.8-0.8-0.8-0.8-0.8-0.80.80.70.70.0
Bone: final moment0.60.91.4-1.2-1.2-0.9-0.91.01.0-1.01.0-1.0-1.01.0-1.0-1.0-1.0-1.0-1.01.00.90.90.0
Food consumed during 24 hour testing period4.96.87.62.62.72.62.6-2.7-2.72.7-2.62.72.7-2.72.72.72.72.72.7-2.8-2.7-2.70.0
Glucose0.30.41.00.91.00.80.7-0.7-0.70.7-0.70.70.7-0.70.70.60.60.60.6-0.5-0.5-0.50.0
Heart weight2.03.13.8-1.6-1.6-1.7-1.71.81.8-1.81.5-1.8-1.81.8-1.8-1.8-1.8-1.9-1.91.91.91.90.0
Delay discount hyperbolic model param0.91.01.4-1.0-0.8-1.0-1.01.01.0-1.00.8-1.0-1.01.1-1.1-1.1-1.1-1.2-1.21.01.11.10.0
Intermittent access intake day 1-15 change0.10.10.2-0.4-0.5-0.4-0.40.40.4-0.40.4-0.4-0.40.4-0.4-0.4-0.4-0.4-0.40.40.40.40.0
Intermittent access intake escalation0.10.20.4-0.6-0.7-0.5-0.60.50.5-0.50.5-0.5-0.50.5-0.5-0.5-0.5-0.5-0.50.50.40.40.0
Intermittent access intake escalation 20.00.00.20.30.30.40.3-0.0-0.00.0-0.00.00.00.0-0.0-0.0-0.0-0.1-0.10.10.10.20.0
Intermitt. access day 1 inactive lever presses0.00.00.2-0.3-0.5-0.3-0.20.20.2-0.10.4-0.1-0.20.1-0.1-0.1-0.1-0.1-0.10.1-0.0-0.00.0
Intermitt. access day 15 inactive lever presses0.00.10.7-0.3-0.2-0.6-0.50.10.1-0.10.8-0.1-0.10.1-0.1-0.1-0.0-0.0-0.00.0-0.0-0.00.0
Intermitt. access escalation Index0.20.30.40.60.60.50.5-0.5-0.50.5-0.50.50.5-0.50.50.50.50.60.6-0.6-0.5-0.50.0
Intermittent access day 1 total infusions1.82.84.8-2.2-2.1-2.0-2.11.71.7-1.71.6-1.7-1.71.7-1.6-1.6-1.6-1.5-1.51.51.41.40.0
Intermittent access day 15 total infusions1.01.42.8-1.4-1.4-1.7-1.71.21.2-1.21.4-1.1-1.21.1-1.1-1.1-1.1-1.1-1.11.11.01.00.0
Intermittent access terminal intake (last 3 days)1.21.62.5-1.4-1.4-1.6-1.51.31.3-1.31.4-1.3-1.21.3-1.2-1.3-1.2-1.2-1.21.21.21.20.0
Intermittent access total infusions2.73.24.8-2.0-1.9-2.2-2.11.81.8-1.82.0-1.8-1.81.8-1.8-1.8-1.7-1.7-1.71.71.61.60.0
Intermittent access day 1 locomotion0.40.51.3-0.9-1.0-1.1-1.20.70.7-0.70.9-0.7-0.70.7-0.7-0.7-0.6-0.6-0.60.60.50.50.0
Intermittent access day 15 total locomotion0.20.30.8-0.7-0.6-0.7-0.90.50.5-0.50.6-0.5-0.50.5-0.5-0.5-0.5-0.5-0.50.50.40.40.0
Intermittent access total locomotion1.82.13.3-1.6-1.6-1.7-1.81.51.5-1.51.6-1.5-1.41.4-1.4-1.4-1.4-1.4-1.41.41.31.30.0
Intermittent access standard deviation0.10.20.30.60.50.40.4-0.5-0.50.5-0.20.50.5-0.50.50.50.40.40.4-0.4-0.4-0.40.0
Left kidney weight5.324.831.2-5.6-5.6-5.1-5.15.25.2-5.25.1-5.1-5.15.1-5.1-5.1-5.0-4.9-4.94.94.84.80.0
Right kidney weight4.922.326.6-5.1-5.2-4.8-4.84.94.9-4.94.9-4.9-4.84.9-4.8-4.9-4.8-4.7-4.74.74.74.70.0
Cocaine induced anxiety0.10.10.30.10.0-0.3-0.2-0.3-0.40.40.00.40.3-0.40.40.40.40.50.5-0.5-0.5-0.60.0
Post-drug Anxiety0.00.00.00.10.1-0.1-0.0-0.1-0.10.2-0.10.10.1-0.20.20.20.10.10.1-0.1-0.1-0.10.0
Baseline Anxiety0.20.21.00.91.00.80.8-0.2-0.20.2-0.60.20.2-0.10.10.10.0-0.1-0.10.10.20.30.0
Tail length0.51.83.8-1.7-2.0-1.4-1.41.41.4-1.31.6-1.3-1.41.3-1.3-1.3-1.2-1.1-1.11.21.11.10.0
Length with tail0.41.73.5-1.7-1.9-1.5-1.51.41.4-1.31.6-1.3-1.41.3-1.3-1.3-1.2-1.1-1.11.11.11.10.0
Length without tail0.31.11.8-1.3-1.2-1.3-1.31.11.1-1.11.3-1.1-1.01.1-1.0-1.1-1.0-0.9-0.90.90.90.90.0
Times rat made contact with spout0.10.10.20.30.40.40.4-0.2-0.20.2-0.30.20.2-0.20.20.20.20.20.2-0.2-0.1-0.10.0
Lifetime Intake2.73.35.2-2.1-2.1-2.3-2.21.91.8-1.82.0-1.8-1.81.8-1.8-1.8-1.8-1.7-1.71.71.61.60.0
Liver weight, left2.23.74.7-2.2-2.1-2.0-2.02.02.0-2.01.9-2.0-2.02.0-2.0-1.9-2.0-1.8-1.81.91.91.90.0
Liver weight, right1.52.54.3-2.0-2.1-1.8-1.91.71.7-1.61.7-1.6-1.71.6-1.6-1.6-1.5-1.3-1.31.31.41.30.0
Locomotor activity2.03.24.0-1.8-1.6-1.6-1.61.81.8-1.81.7-1.8-1.81.9-1.8-1.9-1.9-2.0-2.02.01.92.00.0
Locomotor testing distance1.12.12.4-1.6-1.4-1.5-1.51.51.5-1.51.3-1.5-1.41.5-1.5-1.5-1.5-1.6-1.61.61.41.40.0
Locomotor testing rearing4.38.710.5-3.2-3.1-3.1-3.13.03.0-3.03.0-3.0-3.03.0-3.0-3.0-3.0-3.0-3.03.02.92.90.0
Locomotion in novel chamber0.40.51.50.91.01.21.2-0.6-0.60.6-1.00.60.6-0.50.50.50.50.40.4-0.3-0.3-0.30.0
Locomotion in novel chamber post-restriction0.91.52.61.41.21.61.5-1.2-1.21.2-1.31.21.2-1.21.21.21.21.11.1-1.2-1.2-1.10.0
Fecal boli incidents, locomotor time 10.00.10.2-0.4-0.5-0.1-0.10.30.3-0.30.3-0.3-0.30.2-0.2-0.2-0.2-0.3-0.30.20.20.20.0
Change in fecal boli incidents, locomotor task0.70.60.91.00.60.70.8-0.8-0.80.8-0.70.80.8-0.80.80.80.90.90.9-0.9-0.9-0.90.0
Time >=10cm from walls, locomotor time 10.00.00.00.00.00.0-0.0-0.0-0.00.0-0.10.00.0-0.00.00.00.10.10.1-0.1-0.1-0.10.0
Bouts of movement, locomotor time 12.32.63.11.81.71.71.6-1.7-1.71.7-1.51.71.7-1.71.71.71.71.71.7-1.7-1.6-1.60.0
Total resting periods, locomotor time 12.93.23.71.91.81.81.7-1.9-1.91.9-1.61.91.9-1.91.91.91.91.91.9-1.9-1.9-1.90.0
Rest time, locomotor task time 10.20.20.30.60.40.50.4-0.5-0.50.5-0.30.50.5-0.50.50.50.50.40.4-0.5-0.5-0.50.0
Distance moved, locomotor task time 10.40.50.8-0.9-0.7-0.8-0.80.80.8-0.80.7-0.8-0.80.8-0.7-0.8-0.8-0.7-0.70.80.80.80.0
Vertical activity count, locomotor time 10.00.00.2-0.4-0.4-0.3-0.30.10.1-0.10.0-0.1-0.10.0-0.0-0.0-0.0-0.0-0.0-0.0-0.1-0.10.0
Time >=10cm from walls, locomotor time 20.00.10.20.20.20.30.2-0.2-0.20.2-0.40.20.2-0.20.20.30.20.20.2-0.2-0.3-0.30.0
Bouts of movement, locomotor time 24.77.59.93.13.12.82.7-2.8-2.82.8-2.72.82.8-2.82.82.82.72.82.8-2.7-2.6-2.60.0
Total resting periods, locomotor time 23.86.79.63.03.12.72.6-2.7-2.72.7-2.52.72.7-2.62.62.62.62.72.7-2.5-2.5-2.40.0
Rest time, locomotor task time 20.10.10.30.40.50.30.2-0.3-0.30.3-0.00.30.3-0.30.30.20.30.20.2-0.3-0.2-0.20.0
Distance moved, locomotor task time 20.81.01.4-1.2-1.1-0.9-1.01.01.0-1.00.9-1.0-1.01.0-1.0-1.0-1.0-0.9-0.91.01.00.90.0
Vertical activity count, locomotor time 20.00.00.2-0.2-0.40.0-0.0-0.1-0.10.1-0.20.10.1-0.20.20.20.20.20.2-0.2-0.3-0.40.0
Light reinforcement 10.10.10.2-0.4-0.5-0.5-0.50.40.4-0.40.2-0.4-0.40.4-0.4-0.4-0.3-0.4-0.40.30.30.30.0
Light reinforcement 20.20.31.1-1.0-1.1-0.8-0.80.50.5-0.40.7-0.4-0.50.4-0.4-0.4-0.3-0.4-0.40.30.10.10.0
Bone: marrow area0.00.00.1-0.1-0.20.20.2-0.1-0.10.1-0.20.10.1-0.10.10.10.20.10.1-0.1-0.3-0.30.0
Bone: maximum diameter2.24.14.9-2.2-2.2-1.9-2.02.12.1-2.12.0-2.1-2.12.1-2.1-2.1-2.1-2.1-2.12.12.02.00.0
Bone: maximum force0.20.30.5-0.6-0.7-0.5-0.40.60.6-0.60.5-0.6-0.60.6-0.6-0.6-0.5-0.5-0.50.50.50.50.0
Bone: maximum moment0.20.40.8-0.8-0.9-0.5-0.50.70.7-0.70.6-0.7-0.70.7-0.7-0.7-0.6-0.7-0.70.70.60.60.0
Mean time between licks in bursts0.00.10.10.20.10.20.2-0.2-0.20.2-0.10.20.2-0.20.20.20.30.30.3-0.3-0.3-0.30.0
Mean num. licks in bursts2.94.55.22.32.22.32.3-2.1-2.12.1-2.32.12.2-2.12.12.12.22.22.2-2.2-2.1-2.10.0
Cd content in liver0.10.10.50.50.70.20.2-0.4-0.40.3-0.20.30.4-0.30.30.30.30.30.3-0.3-0.2-0.20.0
Co content in liver1.11.31.51.11.21.01.0-1.2-1.21.2-1.01.21.2-1.21.21.21.21.21.2-1.2-1.2-1.20.0
Cu content in liver0.40.50.8-0.8-0.7-0.9-0.80.70.7-0.70.8-0.7-0.70.7-0.7-0.7-0.7-0.7-0.70.60.60.60.0
Fe content in liver4.85.86.9-2.4-2.0-2.5-2.52.42.5-2.52.5-2.5-2.42.5-2.5-2.5-2.5-2.5-2.52.52.62.60.0
K content in liver0.30.20.7-0.8-0.8-0.5-0.40.50.5-0.50.4-0.5-0.50.5-0.5-0.4-0.5-0.5-0.50.50.40.30.0
Mg content in liver0.60.71.1-1.0-1.1-0.8-0.80.90.9-0.80.8-0.8-0.90.8-0.8-0.8-0.8-0.8-0.80.80.70.70.0
Mn content in liver1.01.12.1-1.4-1.3-1.1-1.11.11.1-1.11.1-1.1-1.11.1-1.1-1.1-1.0-1.0-1.01.01.00.90.0
Na content in liver0.20.20.4-0.2-0.2-0.4-0.20.40.4-0.40.2-0.4-0.40.4-0.5-0.4-0.5-0.6-0.60.60.60.60.0
Rb content in liver0.00.10.1-0.2-0.1-0.1-0.10.30.3-0.30.1-0.3-0.30.3-0.3-0.3-0.2-0.3-0.30.20.30.30.0
Se content in liver4.04.76.5-2.5-2.2-2.2-2.22.22.2-2.22.2-2.2-2.22.2-2.2-2.2-2.2-2.2-2.22.22.22.20.0
Sr content in liver0.00.00.0-0.2-0.2-0.2-0.20.20.2-0.20.2-0.2-0.20.2-0.2-0.2-0.2-0.2-0.20.20.20.20.0
Zn content in liver0.91.01.6-1.1-1.3-1.1-1.01.01.0-1.01.0-1.0-1.01.0-1.0-1.0-1.0-1.0-1.01.00.90.90.0
Bone: minimum diameter0.20.30.5-0.6-0.7-0.5-0.50.60.6-0.60.4-0.6-0.60.6-0.6-0.6-0.6-0.6-0.60.60.50.50.0
Time in familiar zone, hab. session 10.10.10.2-0.2-0.2-0.2-0.20.40.4-0.40.2-0.4-0.40.4-0.4-0.4-0.4-0.5-0.50.50.50.50.0
Time in novel zone, hab. session 10.70.71.1-1.0-0.9-1.0-1.00.80.8-0.81.0-0.8-0.80.8-0.8-0.8-0.8-0.7-0.70.80.80.80.0
Total zone transitions, hab. session 10.10.10.2-0.3-0.2-0.4-0.40.40.4-0.40.3-0.4-0.40.4-0.4-0.4-0.4-0.4-0.40.40.40.50.0
Total locomotion distance, hab. session 10.40.50.60.70.70.70.7-0.7-0.70.7-0.80.70.7-0.70.70.70.70.80.8-0.7-0.7-0.70.0
Locomotion velocity, hab. session 11.21.61.91.31.21.21.2-1.3-1.31.3-1.31.31.3-1.31.31.31.31.41.4-1.3-1.3-1.30.0
Time in familiar zone, hab. session 20.30.30.6-0.6-0.6-0.7-0.70.60.6-0.60.8-0.6-0.60.6-0.6-0.6-0.6-0.5-0.50.50.60.60.0
Time in novel zone, hab. session 20.10.10.30.50.60.60.6-0.3-0.30.3-0.60.30.3-0.30.30.30.30.20.2-0.2-0.2-0.20.0
Total zone transitions, hab. session 20.50.60.8-0.8-0.6-0.8-0.80.80.8-0.80.7-0.8-0.80.8-0.8-0.8-0.8-0.8-0.80.80.90.90.0
Total locomotion distance, hab. session 20.50.60.70.70.80.70.7-0.8-0.80.8-0.80.80.8-0.80.80.80.80.80.8-0.8-0.8-0.80.0
Locomotion velocity, hab. session 20.30.40.50.60.60.60.6-0.6-0.60.6-0.70.60.6-0.60.60.70.60.70.7-0.7-0.7-0.70.0
Novel to familiar place preference ratio0.40.40.5-0.6-0.7-0.6-0.60.70.7-0.70.5-0.7-0.60.7-0.7-0.7-0.6-0.7-0.70.70.60.70.0
Novelty place preference0.30.30.5-0.5-0.6-0.5-0.50.60.6-0.60.5-0.6-0.60.7-0.7-0.7-0.6-0.7-0.70.70.60.60.0
Time in novel zone, NPP test0.40.50.6-0.6-0.6-0.5-0.50.70.7-0.70.5-0.7-0.70.8-0.8-0.8-0.7-0.8-0.80.80.70.80.0
Total zone transitions, NPP test0.10.10.2-0.2-0.3-0.2-0.20.30.4-0.40.1-0.4-0.30.4-0.4-0.4-0.4-0.4-0.40.40.40.40.0
Total locomotion distance, NPP test0.10.10.2-0.1-0.1-0.1-0.10.30.3-0.30.1-0.3-0.30.3-0.3-0.3-0.3-0.4-0.40.40.40.40.0
Locomotion velocity, NPP test0.00.10.1-0.1-0.1-0.1-0.10.20.2-0.20.0-0.2-0.20.3-0.3-0.3-0.3-0.3-0.30.30.30.30.0
Intraocular pressure0.00.10.50.40.70.50.4-0.2-0.20.2-0.20.20.2-0.10.20.10.10.10.1-0.10.10.10.0
Delta distance traveled before/after self-admin1.41.42.40.70.71.01.0-1.2-1.31.3-1.11.31.2-1.31.31.31.41.31.3-1.2-1.5-1.50.0
Delta ambulatory time before/after self-admin0.30.30.60.30.20.40.5-0.6-0.60.6-0.70.60.6-0.60.60.60.70.60.6-0.6-0.7-0.80.0
Parametrial fat weight0.10.20.3-0.5-0.6-0.4-0.40.40.4-0.40.3-0.4-0.40.4-0.4-0.4-0.4-0.4-0.40.40.30.30.0
Pavlov. Cond. lever latency0.50.71.01.00.91.01.0-0.8-0.80.8-0.90.80.9-0.80.80.80.80.70.7-0.7-0.8-0.80.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.6-0.4-0.4-0.40.40.4-0.30.4-0.3-0.40.3-0.3-0.3-0.3-0.1-0.10.20.20.20.0
Pavlov. Cond. change in total contacts0.50.60.80.60.70.60.6-0.8-0.80.8-0.60.80.8-0.80.80.80.80.90.9-0.9-0.8-0.80.0
Pavlov. Cond. index score0.30.40.7-0.8-0.6-0.7-0.80.60.6-0.60.7-0.6-0.60.6-0.6-0.6-0.6-0.5-0.50.50.50.50.0
Pavlov. Cond. latency score0.10.10.3-0.5-0.3-0.5-0.50.30.3-0.30.4-0.3-0.30.3-0.3-0.3-0.3-0.2-0.20.20.20.20.0
Pavlov. Cond. lever contacts0.40.40.7-0.8-0.7-0.8-0.80.70.7-0.70.8-0.7-0.70.6-0.6-0.6-0.6-0.5-0.50.50.60.60.0
Pavlov. Cond. magazine entry number0.00.00.30.50.20.30.3-0.2-0.20.2-0.30.20.2-0.20.10.20.2-0.0-0.0-0.0-0.1-0.10.0
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.1-0.2-0.3-0.30.20.2-0.20.3-0.2-0.20.2-0.2-0.2-0.2-0.4-0.40.40.30.30.0
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.8-0.6-0.7-0.80.60.6-0.60.7-0.6-0.60.6-0.6-0.6-0.6-0.5-0.50.50.60.60.0
Pavlov. Cond. response bias0.91.11.9-1.4-1.2-1.1-1.21.11.1-1.11.1-1.1-1.11.1-1.0-1.0-1.0-0.8-0.80.90.90.90.0
Pavlov. Cond. lever latency0.00.00.10.20.20.10.1-0.1-0.10.1-0.10.10.1-0.10.10.10.10.20.2-0.2-0.1-0.10.0
Pavlov. Cond. magazine entry latency0.00.00.0-0.1-0.1-0.1-0.20.10.1-0.10.2-0.1-0.00.1-0.0-0.1-0.0-0.0-0.00.0-0.0-0.00.0
Pavlov. Cond. change in total contacts0.20.30.50.60.70.70.7-0.6-0.60.6-0.70.60.6-0.60.60.50.50.50.5-0.5-0.5-0.50.0
Pavlov. Cond. index score0.00.00.10.10.10.20.2-0.2-0.20.2-0.20.20.2-0.20.20.20.20.20.2-0.2-0.2-0.20.0
Pavlov. Cond. latency score0.10.10.10.20.20.30.3-0.3-0.30.3-0.30.30.3-0.30.30.30.30.30.3-0.3-0.3-0.30.0
Pavlov. Cond. lever contacts0.10.10.2-0.5-0.4-0.2-0.30.30.3-0.30.3-0.3-0.30.3-0.3-0.3-0.3-0.3-0.30.30.30.20.0
Pavlov. Cond. magazine entry number0.30.40.5-0.6-0.6-0.6-0.50.70.6-0.70.6-0.7-0.70.7-0.7-0.7-0.7-0.6-0.60.60.70.70.0
Pavlov. Cond. intertrial magazine entries0.00.00.00.00.1-0.00.00.10.1-0.1-0.0-0.1-0.10.1-0.1-0.1-0.1-0.1-0.10.10.20.20.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.1-0.00.0-0.00.00.0-0.00.00.00.00.00.0-0.00.0-0.0-0.00.0-0.0-0.00.0
Pavlov. Cond. response bias0.00.00.0-0.10.00.10.0-0.1-0.00.1-0.10.10.1-0.10.10.10.10.00.0-0.0-0.1-0.10.0
Time in closed arm before self-admin0.81.01.8-1.0-0.8-1.3-1.31.01.0-1.01.2-1.0-0.91.0-1.0-1.0-1.0-1.0-1.01.00.91.00.0
Time in closed arm after self-admin1.01.12.21.51.31.11.0-1.1-1.01.0-1.21.01.1-1.01.01.01.01.01.0-1.0-0.8-0.80.0
Time in open arm before self-admin0.80.91.91.00.81.41.4-0.9-0.90.9-1.10.90.9-0.90.90.90.90.90.9-0.9-0.9-0.90.0
Time in open arm after self-admin0.00.10.2-0.2-0.20.00.2-0.2-0.20.20.00.20.2-0.20.20.30.30.20.2-0.1-0.4-0.40.0
Bone: periosteal estimation0.30.61.1-0.9-1.0-0.6-0.60.80.8-0.80.6-0.8-0.80.8-0.8-0.7-0.7-0.8-0.80.80.70.60.0
Bone: periosteal perimeter0.30.50.9-0.9-0.9-0.6-0.60.70.7-0.70.6-0.7-0.70.7-0.7-0.7-0.7-0.7-0.70.70.60.60.0
Bone: post-yield work0.71.01.41.00.81.00.9-1.0-1.01.0-1.01.01.0-1.01.01.01.11.11.1-1.1-1.2-1.20.0
Progressive ratio test 1 active lever presses2.93.65.4-2.3-2.3-2.1-2.12.01.9-1.92.0-1.9-1.91.9-1.9-1.9-1.8-1.8-1.81.81.71.60.0
Progressive ratio test 1 breakpoint2.73.35.6-2.2-2.4-2.0-2.11.91.9-1.81.9-1.8-1.91.8-1.8-1.8-1.7-1.7-1.71.71.61.50.0
Progressive ratio test 1 inactive lever presses1.52.13.3-1.7-1.8-1.6-1.81.51.5-1.51.6-1.5-1.51.4-1.4-1.4-1.4-1.4-1.41.41.31.20.0
Progressive ratio test 2 active lever presses2.73.14.9-2.2-2.1-2.2-2.11.81.8-1.81.8-1.8-1.81.7-1.7-1.7-1.7-1.7-1.71.71.61.50.0
Progressive ratio test 2 breakpoint3.03.55.4-2.3-2.2-2.3-2.21.91.9-1.92.0-1.9-1.91.8-1.8-1.8-1.8-1.7-1.71.71.61.60.0
Progressive ratio test 2 inactive lever presses0.40.61.8-1.3-1.3-1.3-1.20.70.7-0.60.9-0.7-0.70.6-0.6-0.6-0.5-0.5-0.50.50.30.20.0
Incentive Sensitization - Responses1.31.83.1-1.8-1.5-1.7-1.61.41.4-1.31.3-1.4-1.41.3-1.3-1.3-1.3-1.3-1.31.31.21.20.0
Incentive Sensitization - Breakpoint1.31.72.9-1.7-1.5-1.7-1.61.31.3-1.31.3-1.3-1.31.3-1.3-1.2-1.2-1.2-1.21.21.21.10.0
Sum of active levers in priming session hrs 5-60.30.30.50.50.70.70.7-0.5-0.50.5-0.60.50.5-0.50.50.50.50.40.4-0.4-0.4-0.40.0
Progressive ratio0.91.41.71.31.11.01.0-1.2-1.21.3-1.11.21.2-1.31.21.31.21.21.2-1.3-1.2-1.20.0
Food seeking constrained by brief footshock5.16.36.92.62.62.42.4-2.6-2.62.6-2.62.62.6-2.62.62.62.62.52.5-2.6-2.6-2.60.0
Seeking ratio, punishment vs. effort0.60.91.00.90.91.01.0-0.9-0.90.9-1.00.91.0-0.90.90.91.00.90.9-0.9-1.0-1.00.0
Retroperitoneal fat weight0.00.10.2-0.4-0.4-0.4-0.40.40.4-0.40.5-0.4-0.40.3-0.3-0.3-0.4-0.3-0.30.30.30.30.0
Reaction time number correct3.46.48.3-2.3-2.2-2.3-2.22.62.6-2.72.3-2.7-2.62.7-2.7-2.7-2.7-2.8-2.82.72.92.90.0
Reaction time mean minus median0.20.52.01.41.40.91.0-0.7-0.60.6-0.90.60.7-0.50.50.50.40.30.3-0.3-0.2-0.20.0
Reaction time mean minus median AUC0.00.10.40.60.70.20.20.10.1-0.2-0.1-0.1-0.10.2-0.2-0.2-0.3-0.4-0.40.40.50.50.0
Reaction time num false alarms4.66.58.7-2.9-2.9-2.8-2.92.62.6-2.62.8-2.6-2.62.6-2.6-2.5-2.5-2.5-2.52.42.32.30.0
Reaction time num false alarms AUC3.65.78.0-2.8-2.8-2.6-2.62.52.4-2.42.5-2.4-2.52.4-2.4-2.4-2.3-2.3-2.32.22.22.20.0
Reaction time trials correct on left3.46.48.3-2.3-2.2-2.3-2.22.62.6-2.72.3-2.7-2.62.7-2.7-2.7-2.7-2.8-2.82.72.92.90.0
Reaction time trials on left3.46.48.3-2.3-2.2-2.3-2.22.62.6-2.72.3-2.6-2.62.7-2.7-2.7-2.7-2.7-2.72.72.82.90.0
Reaction time mean1.42.23.82.01.81.61.7-1.5-1.51.5-1.61.51.5-1.51.51.51.51.41.4-1.3-1.4-1.30.0
Reaction time mean AUC1.11.73.21.81.61.51.5-1.3-1.31.3-1.51.31.3-1.31.31.31.31.21.2-1.1-1.2-1.20.0
Median of all reaction times1.62.33.21.81.61.61.6-1.6-1.61.6-1.61.61.6-1.51.61.51.61.51.5-1.5-1.6-1.60.0
Reaction time omissions0.00.00.00.0-0.1-0.0-0.00.00.0-0.00.1-0.0-0.00.0-0.0-0.00.00.10.10.0-0.1-0.10.0
Reaction time false alarm rate0.30.41.1-1.0-1.0-0.8-0.90.60.6-0.50.8-0.5-0.60.5-0.5-0.5-0.4-0.4-0.40.40.30.20.0
Reaction time premature initiation rate0.40.61.20.50.50.80.7-0.7-0.70.7-1.10.70.7-0.80.80.80.80.80.8-0.8-0.8-0.90.0
Reaction time premature initiations0.20.30.4-0.5-0.5-0.4-0.30.60.6-0.60.0-0.6-0.60.6-0.6-0.6-0.6-0.6-0.60.50.60.60.0
Std. dev. reaction times0.30.61.81.41.31.01.0-0.8-0.80.7-0.90.70.8-0.70.70.70.60.50.5-0.5-0.5-0.40.0
Reaction time trials completed3.46.48.3-2.3-2.2-2.3-2.22.62.6-2.72.3-2.6-2.62.7-2.7-2.7-2.7-2.7-2.72.72.82.90.0
Reaction time trials AUC4.17.99.9-2.6-2.5-2.6-2.52.92.9-2.92.6-2.9-2.93.0-3.0-3.0-3.0-3.0-3.03.03.13.10.0
Run reversals in cocaine runway, females0.20.20.30.50.30.40.4-0.5-0.50.5-0.50.50.5-0.50.50.50.60.50.5-0.5-0.6-0.60.0
Run reversals in cocaine runway, males0.40.40.5-0.7-0.6-0.6-0.60.70.7-0.70.7-0.7-0.70.7-0.7-0.7-0.7-0.7-0.70.70.70.70.0
Latency to leave start box in cocaine runway0.10.10.50.40.30.40.50.00.0-0.1-0.7-0.10.00.1-0.1-0.1-0.1-0.2-0.20.30.30.30.0
Latency to leave start box in cocaine runway, F0.40.51.0-0.1-0.3-0.2-0.10.70.7-0.7-0.3-0.7-0.60.7-0.8-0.8-0.8-0.9-0.91.01.01.00.0
Latency to leave start box in cocaine runway, M0.20.10.20.30.40.40.4-0.4-0.40.4-0.30.40.4-0.40.40.40.40.40.4-0.4-0.4-0.40.0
Std. dev. time between licks in bursts0.00.00.2-0.4-0.4-0.2-0.20.20.2-0.20.2-0.2-0.20.1-0.1-0.1-0.10.10.1-0.0-0.0-0.10.0
Total sessions with >9 infusions3.84.65.6-2.4-2.2-2.3-2.42.22.2-2.22.2-2.2-2.22.2-2.2-2.2-2.2-2.1-2.12.12.12.10.0
Short access day 1 total inactive lever presses1.01.44.1-1.8-2.0-1.7-1.71.11.1-1.01.3-1.1-1.11.0-1.0-0.9-0.9-0.8-0.80.80.60.50.0
Short access day 10 total inactive lever presses0.51.21.41.11.11.01.1-1.2-1.21.2-0.91.21.1-1.21.21.21.21.11.1-1.1-1.2-1.20.0
Short access day 1 total infusions2.12.73.8-1.9-1.8-1.9-1.81.71.7-1.71.6-1.7-1.71.7-1.7-1.7-1.7-1.6-1.61.61.61.60.0
Short access day 10 total infusions3.84.86.3-2.5-2.5-2.5-2.42.32.3-2.22.2-2.2-2.22.2-2.2-2.2-2.2-2.1-2.12.12.12.10.0
Short access total infusions2.53.24.6-2.2-2.1-2.1-2.11.81.8-1.81.9-1.8-1.81.8-1.8-1.8-1.7-1.7-1.71.71.61.60.0
Short access day 1 locomotion3.74.67.6-2.6-2.5-2.7-2.82.22.2-2.12.4-2.1-2.22.1-2.1-2.1-2.1-2.0-2.02.01.91.90.0
Short access day 10 total locomotion0.00.00.00.20.20.10.0-0.0-0.0-0.00.0-0.00.00.0-0.0-0.0-0.0-0.0-0.00.00.10.10.0
Short access total locomotion0.81.01.7-1.1-1.2-1.3-1.31.01.0-1.01.1-1.0-1.01.0-1.0-1.0-1.0-0.9-0.90.90.90.90.0
One hour access (0.3 mA shock)0.10.10.2-0.4-0.4-0.3-0.30.20.2-0.20.4-0.2-0.20.2-0.2-0.2-0.2-0.2-0.20.20.10.10.0
Compulsive drug intake0.10.10.3-0.0-0.10.00.30.30.3-0.40.2-0.4-0.30.4-0.4-0.4-0.4-0.5-0.50.50.50.50.0
One hour access (shock baseline)1.11.73.3-1.5-1.5-1.7-1.81.31.3-1.21.6-1.2-1.31.2-1.2-1.2-1.2-1.1-1.11.11.11.10.0
Social response proportion0.70.81.1-0.8-0.8-0.8-0.80.90.9-1.01.0-1.0-0.91.0-1.0-1.0-1.0-0.9-0.91.01.01.00.0
Social responses0.70.91.1-1.0-1.0-0.9-0.91.01.0-1.01.0-1.0-1.01.0-1.0-1.0-1.0-1.0-1.01.01.01.00.0
Social time3.34.56.11.91.72.42.4-2.1-2.12.1-2.52.12.1-2.12.12.22.22.22.2-2.1-2.2-2.20.0
Soleus weight0.10.40.6-0.7-0.8-0.7-0.60.60.6-0.60.6-0.6-0.60.6-0.6-0.6-0.6-0.6-0.60.60.50.50.0
Bone: stiffness0.71.21.5-1.1-1.2-1.1-1.11.11.1-1.11.0-1.1-1.11.1-1.1-1.1-1.1-1.2-1.21.21.11.10.0
Tibialis anterior weight3.311.213.7-3.7-3.7-3.6-3.53.43.4-3.43.4-3.4-3.43.4-3.4-3.4-3.3-3.4-3.43.43.23.20.0
Time to tail flick, vehicle, before self-admin2.82.93.7-1.9-1.8-1.6-1.71.81.8-1.81.6-1.8-1.81.8-1.8-1.8-1.8-1.8-1.81.81.81.80.0
Time to tail flick, vehicle, after self-admin0.10.10.30.60.50.50.6-0.1-0.00.0-0.40.00.10.0-0.0-0.0-0.1-0.1-0.10.00.30.30.0
Time to tail flick, test, before self-admin0.30.30.50.70.70.30.2-0.6-0.60.6-0.30.60.6-0.60.60.60.60.70.7-0.6-0.6-0.60.0
Time to tail flick, test, after self-admin0.10.10.50.1-0.30.20.1-0.3-0.30.3-0.70.30.3-0.40.40.40.40.50.5-0.6-0.5-0.50.0
Delta time to tail flick, vehicle, before/after SA0.30.31.00.90.80.91.0-0.5-0.40.4-0.60.40.4-0.40.40.40.30.40.4-0.4-0.2-0.20.0
Delta time to tail flick, test, before/after SA0.80.81.8-1.2-1.3-0.7-0.80.90.9-0.90.5-0.9-0.90.9-0.9-0.9-0.9-0.9-0.90.90.90.90.0
Tibia length0.20.71.5-1.1-1.1-0.9-1.20.80.9-0.80.9-0.8-0.80.8-0.7-0.8-0.7-0.6-0.60.60.60.60.0
Ambulatory time before self-admin0.00.00.20.20.30.30.1-0.1-0.10.1-0.40.10.1-0.10.10.10.10.10.1-0.1-0.0-0.00.0
Ambulatory time after self-admin0.50.61.50.80.80.90.8-0.8-0.80.8-1.20.80.8-0.80.70.70.70.70.7-0.6-0.7-0.70.0
Bone: tissue strength0.80.80.91.00.90.90.9-0.9-0.90.9-0.90.90.9-0.90.90.91.00.90.9-0.9-1.0-1.00.0
Total heroin consumption0.00.00.1-0.3-0.20.20.1-0.0-0.00.00.20.00.0-0.00.10.10.10.10.1-0.1-0.2-0.20.0
Bone: trabecular number0.00.10.20.10.1-0.0-0.0-0.2-0.20.2-0.10.20.2-0.20.20.20.30.50.5-0.4-0.3-0.40.0
Bone: trabecular spacing0.00.00.1-0.1-0.10.00.10.20.2-0.2-0.0-0.2-0.20.2-0.2-0.2-0.2-0.4-0.40.30.30.30.0
Bone: trabecular thickness1.41.72.2-1.5-1.4-1.4-1.51.41.4-1.41.4-1.3-1.31.4-1.3-1.4-1.3-1.2-1.21.21.31.30.0
Bone: trabecular tissue density0.30.40.5-0.7-0.5-0.5-0.60.70.7-0.70.5-0.7-0.70.7-0.6-0.7-0.7-0.6-0.60.70.70.70.0
Water consumed over 24 hours0.20.20.40.60.70.60.6-0.5-0.50.5-0.50.50.5-0.50.50.50.50.50.5-0.5-0.4-0.40.0
Number of responses in last shaping day2.83.14.7-1.6-1.5-1.8-1.91.81.8-1.82.2-1.8-1.81.8-1.8-1.8-1.8-1.8-1.81.81.91.90.0