Hub : Genes

Disp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Disp2 0.04 0.03 1.1e-03 0.02 0.01 0.01 0.01 4.7e-03 1.6e-02 5.9e-02 2.1e-02
2 Brain gene expression Disp2 0.14 0.07 8.0e-10 0.09 0.11 0.12 0.12 2.5e-08 2.5e-10 4.1e-11 3.5e-11
3 IL gene expression Disp2 0.16 0.1 9.3e-03 0.04 0.04 0.03 0.04 3.9e-02 4.1e-02 5.6e-02 4.7e-02
4 OFC gene expression Disp2 0.17 0.1 9.0e-03 0.1 0.05 0.02 0.08 2.1e-03 2.1e-02 1.1e-01 5.5e-03
5 LHb gene expression Disp2 0.23 0.12 2.9e-03 0.01 0.02 0.04 0.02 1.4e-01 1.1e-01 3.2e-02 1.2e-01
6 Adipose gene expression Disp2 0.21 0.09 0.0e+00 0.11 0.14 0.15 0.14 5.3e-12 1.1e-15 1.6e-16 2.0e-15
7 PL gene expression Disp2 0.03 0.02 8.3e-03 -0 0 0 0 5.9e-01 9.6e-02 2.1e-01 3.1e-01
8 Brain mRNA stability Disp2 0.05 0.03 1.3e-03 0.03 0.04 0.03 0.03 3.6e-04 1.7e-04 5.6e-04 7.4e-04
9 BLA intron excision ratio chr3_126223009_126223375 0.19 0.09 1.4e-04 0.11 0.07 0.07 0.08 2.7e-06 2.1e-04 1.7e-04 7.2e-05
10 BLA intron excision ratio chr3_126223404_126223545 0.2 0.1 8.7e-05 0.1 0.06 0.07 0.08 6.8e-06 2.5e-04 1.7e-04 3.8e-05
11 PL mRNA stability Disp2 0.06 0.04 8.8e-05 0.05 0.04 0.03 0.04 3.2e-06 6.5e-05 1.4e-04 1.3e-05
12 pVTA intron excision ratio chr3_126223404_126223545 0.08 0.05 4.7e-04 0.07 0.04 0.04 0.05 3.9e-06 5.4e-04 6.3e-04 6.3e-05
13 pVTA intron excision ratio chr3_126223009_126223375 0.08 0.04 1.3e-03 0.06 0.03 0.04 0.05 9.7e-06 1.5e-03 1.6e-04 9.3e-05
14 Brain intron excision ratio chr3_126223009_126223375 0.06 0.04 2.2e-03 0.04 0.03 0.04 0.04 4.7e-05 4.4e-04 1.4e-04 1.0e-04
15 Brain intron excision ratio chr3_126223404_126223545 0.07 0.04 1.1e-03 0.04 0.04 0.03 0.04 5.0e-05 2.0e-04 4.2e-04 5.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.61.81.11.31.31.31.00.50.8-0.10.5-0.5-0.4-0.30.30.2-0.2
Area under the delay curve2.83.36.20.92.21.31.32.5-1.01.7-0.92.5-2.5-0.3-2.02.02.0-2.0
BMI with tail1.55.319.34.44.33.33.32.52.70.91.70.7-0.70.7-0.50.50.4-0.4
BMI without tail2.57.726.85.24.64.54.52.73.31.81.40.6-0.6-0.2-0.80.80.8-0.8
Body weight1.67.228.15.34.93.93.92.63.11.12.00.7-0.70.9-0.60.60.6-0.6
Weight adjusted by age0.30.41.71.31.20.40.40.50.5-0.10.70.2-0.20.8-0.50.50.4-0.4
Bone surface0.40.71.71.30.91.01.00.31.3-0.10.8-0.60.60.30.8-0.8-0.90.9
Bone volume0.50.81.81.31.21.11.10.71.20.00.8-0.60.60.40.8-0.8-1.01.0
Breakpoint value in progressive ratio session0.10.10.5-0.70.1-0.1-0.10.3-0.1-0.0-0.2-0.00.0-0.00.6-0.6-0.50.5
Number of licking bursts0.20.30.8-0.9-0.20.10.10.2-0.20.2-0.4-0.30.3-0.50.9-0.9-0.80.8
Context. condit. distance diff. score1.01.23.51.91.11.91.90.61.60.60.5-1.01.0-0.50.4-0.4-0.50.5
Locomotion velocity, session 12.12.25.7-2.3-1.7-1.5-1.5-0.4-2.40.4-1.71.6-1.6-0.8-1.21.21.2-1.2
Locomotion distance, session 11.41.73.2-1.6-1.3-1.0-1.0-0.4-1.80.6-1.51.6-1.6-1.0-1.31.31.3-1.3
Locomotion velocity, session 22.83.36.10.11.41.31.31.9-1.32.1-1.72.5-2.5-1.4-2.12.12.1-2.1
Locomotion distance, session 20.70.91.9-1.2-0.9-0.3-0.3-0.2-1.20.8-1.41.2-1.2-1.3-0.90.90.9-0.9
Locomotion velocity, session 30.70.82.8-0.71.00.50.51.7-1.41.0-1.01.0-1.0-0.5-0.60.60.5-0.5
Locomotion distance, session 30.50.51.1-0.20.80.90.91.10.10.6-0.3-0.10.1-0.50.9-0.9-0.90.9
Stereotopy head waving bouts, day 30.81.04.11.72.01.21.21.40.50.40.60.2-0.20.7-0.70.70.6-0.6
Stereotopy head waving duration, day 31.72.05.21.42.31.51.52.1-0.31.2-0.21.2-1.2-0.0-1.61.61.5-1.5
Locomotion velocity, session 70.30.41.20.70.91.11.10.80.40.7-0.10.2-0.2-0.6-0.00.0-0.00.0
Locomotion distance, session 70.30.40.90.5-0.20.50.5-0.50.9-0.10.3-0.80.8-0.40.7-0.7-0.80.8
Stereotopy head waving bouts, day 70.20.20.7-0.3-0.1-0.6-0.6-0.0-0.3-0.60.4-0.50.50.80.4-0.4-0.40.4
Stereotopy head waving duration, day 70.50.51.9-0.00.1-0.7-0.7-0.10.1-1.00.9-0.70.71.40.7-0.7-0.80.8
Locomotion velocity, session 82.12.64.01.21.72.02.02.0-0.42.0-1.01.3-1.3-1.2-1.71.71.7-1.7
Locomotion distance, session 80.50.72.10.80.41.51.50.50.51.2-0.60.4-0.4-1.4-0.50.50.4-0.4
Degree of sensitization distance1.21.23.50.2-1.4-1.1-1.1-1.90.9-1.41.1-1.41.40.90.7-0.7-0.60.6
Degree of sensitization stereotypy1.21.21.9-0.2-0.6-1.0-1.0-1.00.6-1.41.1-1.31.31.21.3-1.3-1.31.3
Conditioned locomotion0.80.93.21.71.21.81.80.91.20.80.2-0.20.2-0.4-0.30.30.2-0.2
Cocaine response after cond. corrected0.70.82.7-1.6-0.20.40.41.2-1.61.1-1.60.0-0.0-1.3-0.00.0-0.10.1
Cocaine response after cond. not corrected1.01.23.9-1.9-0.50.10.11.1-2.01.2-1.90.6-0.6-1.5-0.40.40.3-0.3
Cocaine response before conditioning0.60.72.0-0.4-0.5-0.6-0.6-0.5-0.60.2-0.51.4-1.4-0.2-1.01.01.1-1.1
Saline control response0.81.03.61.90.90.20.2-0.51.6-1.01.8-0.70.71.60.2-0.2-0.30.3
Bone: connectivity density0.10.20.70.90.2-0.0-0.0-0.40.7-0.50.70.1-0.10.7-0.10.10.0-0.0
Bone: cortical apparent density2.43.36.1-0.5-1.3-1.2-1.2-1.71.2-1.91.4-2.02.01.32.5-2.5-2.52.5
Bone: cortical area0.50.83.41.61.91.31.31.10.90.40.60.3-0.30.40.0-0.00.0-0.0
Bone: cortical porosity4.34.78.3-1.50.30.80.81.7-2.52.6-2.92.5-2.5-2.6-2.42.42.4-2.4
Bone: cortical porosity3.23.44.9-0.60.91.01.01.8-1.82.2-2.12.2-2.2-2.0-2.12.12.2-2.2
Bone: cortical thickness0.61.02.91.11.71.21.21.30.30.9-0.11.1-1.1-0.1-0.70.70.7-0.7
Bone: cortical thickness0.30.31.0-0.50.40.70.71.0-0.20.5-0.4-0.20.2-0.50.7-0.7-0.70.7
Bone: cortical tissue density2.23.05.7-0.6-1.3-1.2-1.2-1.61.1-1.81.4-1.91.91.32.4-2.4-2.42.4
Condit. Reinf. active minus inactive responses2.52.86.10.4-1.2-1.7-1.7-2.31.4-2.52.1-1.31.32.21.5-1.5-1.41.4
Condit. Reinf. active-inactive response ratio0.80.92.41.10.3-0.2-0.2-0.71.3-1.21.6-0.70.71.50.9-0.9-0.80.8
Condit. Reinf. active responses4.55.611.7-0.0-2.2-2.7-2.7-3.41.7-3.32.5-2.02.02.72.2-2.2-2.12.1
Condit. Reinf. inactive responses2.83.47.3-0.7-2.2-2.2-2.2-2.71.0-2.21.4-1.71.71.51.8-1.8-1.81.8
Incentive salience index mean2.93.69.6-0.4-2.1-2.6-2.6-3.11.0-2.71.9-0.90.92.21.4-1.4-1.31.3
Condit. Reinf. lever presses2.02.88.9-0.7-2.3-2.6-2.6-3.00.5-2.31.3-0.30.31.70.9-0.9-0.90.9
Condit. Reinf. active minus inactive responses1.92.55.41.6-0.3-0.4-0.4-1.72.3-1.92.3-1.71.71.61.5-1.5-1.51.5
Condit. Reinf. active-inactive response ratio1.51.73.81.3-0.1-0.1-0.1-1.21.9-1.41.8-1.51.51.21.4-1.4-1.31.3
Condit. Reinf. active responses2.63.68.12.10.0-0.5-0.5-1.82.8-2.32.8-1.91.92.21.8-1.8-1.81.8
Condit. Reinf. inactive responses1.41.94.81.30.3-0.9-0.9-1.21.8-1.82.2-1.11.12.21.2-1.2-1.11.1
Condit. Reinf. lever presses1.82.57.61.60.4-1.0-1.0-1.31.9-2.32.7-1.11.12.81.3-1.3-1.21.2
Condit. Reinf. lever reinforcers received2.83.98.91.9-0.2-0.9-0.9-2.22.8-2.63.0-1.91.92.51.7-1.7-1.71.7
Conditioned reinforcement - actives0.50.82.2-0.6-0.2-0.3-0.30.2-1.00.5-0.81.5-1.5-0.5-1.11.11.1-1.1
Conditioned reinforcement - inactives0.20.30.80.20.50.90.90.60.20.8-0.40.7-0.7-0.9-0.20.20.3-0.3
Conditioned locomotion0.91.23.8-0.20.0-0.7-0.70.2-1.10.0-0.32.0-2.00.5-1.41.41.4-1.4
Patch foraging indifference point 0 sec0.71.34.71.91.60.00.00.40.7-0.91.60.9-0.92.2-0.90.91.0-1.0
Patch foraging indifference point AUC0.50.82.1-1.5-1.4-1.4-1.4-0.8-1.0-0.7-0.3-0.20.20.30.4-0.4-0.40.4
Delay disc. indifference point, 0s delay0.50.51.20.10.5-0.6-0.60.4-0.7-0.20.11.1-1.11.0-0.90.90.9-0.9
Delay disc. indifference point, 16s delay1.71.94.5-0.21.40.60.62.1-1.61.4-1.22.0-2.0-0.5-1.41.41.4-1.4
Delay disc. indifference point, 2s delay0.50.52.21.51.00.70.70.11.3-0.31.0-0.30.30.70.2-0.2-0.20.2
Delay disc. indifference point, 24s delay1.01.12.2-1.3-0.8-1.0-1.0-0.1-1.50.2-0.91.5-1.5-0.2-1.01.01.0-1.0
Delay disc. indifference point, 4s delay2.22.35.40.51.20.90.91.5-0.71.4-1.02.3-2.3-0.7-1.91.91.9-1.9
Delay disc. indifference point, 8s delay3.23.79.91.53.11.81.83.0-0.61.7-0.62.3-2.30.1-1.81.81.8-1.8
Indifference point function ln k1.32.37.12.22.32.72.71.91.31.6-0.00.4-0.4-1.0-0.60.60.5-0.5
Indifference point function log k1.32.37.12.22.32.72.71.91.31.6-0.00.4-0.4-1.0-0.60.60.5-0.5
Patch foraging total patch changes 0 sec0.61.14.71.81.5-0.0-0.00.40.7-0.91.60.6-0.62.2-0.50.50.6-0.6
Patch foraging total patch changes 12 sec0.50.62.90.2-0.4-1.2-1.2-0.90.1-1.31.00.2-0.21.70.2-0.2-0.00.0
Patch foraging total patch changes 18 sec0.20.41.1-0.3-0.7-1.1-1.1-0.7-0.4-0.90.4-0.30.30.90.2-0.2-0.10.1
Patch foraging total patch changes 24 sec0.50.81.61.21.20.60.60.9-0.10.20.31.0-1.00.5-1.11.11.3-1.3
Patch foraging total patch changes 6 sec0.20.41.90.1-0.0-0.8-0.8-0.50.0-1.00.80.4-0.41.40.1-0.10.2-0.2
Patch foraging time to switch 0 sec0.81.64.0-0.4-1.2-2.0-2.0-1.90.4-1.91.3-0.70.71.70.5-0.5-0.70.7
Patch foraging water rate 0 sec0.51.12.61.31.21.61.60.91.30.20.6-0.70.70.11.0-1.0-1.01.0
Patch foraging water rate 12 sec0.40.82.3-0.10.61.41.41.00.31.1-0.7-0.50.5-1.50.6-0.6-0.60.6
Patch foraging water rate 18 sec0.81.33.40.21.51.71.71.8-0.31.7-1.10.4-0.4-1.4-0.50.50.6-0.6
Patch foraging water rate 24 sec1.52.24.50.90.91.31.30.31.8-0.21.0-1.61.60.32.1-2.1-2.12.1
Patch foraging water rate 6 sec0.81.22.8-1.0-0.60.40.4-0.10.30.1-0.3-1.61.6-0.61.7-1.7-1.71.7
Seeking ratio, delayed vs. immediate footshock0.50.62.20.80.30.60.6-0.61.5-0.30.7-1.11.1-0.20.8-0.8-0.80.8
Distance traveled before self-admin0.60.81.80.61.30.90.91.10.00.9-0.30.9-0.9-0.5-0.90.91.0-1.0
Distance traveled after self-admin0.10.20.30.30.50.00.00.10.4-0.30.5-0.50.50.50.5-0.5-0.40.4
Extensor digitorum longus weight0.20.72.90.51.61.31.31.7-0.21.0-0.40.3-0.3-0.3-0.30.30.3-0.3
Bone: elastic displacement0.10.20.4-0.20.4-0.3-0.30.3-0.50.0-0.10.6-0.60.2-0.50.50.5-0.5
Bone: elastic work0.30.31.30.91.10.10.10.30.7-0.51.0-0.00.01.20.3-0.3-0.20.2
Bone: endosteal estimation0.20.40.90.30.31.01.00.50.40.5-0.1-0.80.8-0.60.5-0.5-0.50.5
Bone: endosteal perimeter0.10.10.40.30.10.40.40.10.30.10.1-0.70.7-0.10.4-0.4-0.30.3
Epididymis fat weight0.82.94.30.71.61.61.61.9-0.92.0-1.31.9-1.9-1.4-2.12.12.1-2.1
Delta time in closed arm before/after self-admin0.20.20.70.3-0.30.40.4-0.60.90.00.1-0.00.0-0.60.3-0.3-0.40.4
Delta time in open arm before/after self-admin0.90.92.61.21.21.61.61.01.10.60.4-0.80.8-0.40.7-0.7-0.70.7
Diff in mean of infusions in LGA sessions0.60.72.0-0.1-0.8-1.2-1.2-1.40.7-1.31.0-0.30.31.10.4-0.4-0.40.4
Delay discount exponential model param2.73.05.8-0.7-1.9-1.3-1.3-2.20.9-1.71.0-2.42.40.62.0-2.0-2.02.0
Extinction: sum of active levers before priming0.50.61.8-1.3-0.6-0.8-0.8-0.1-1.10.2-0.81.0-1.0-0.3-0.60.60.6-0.6
Active lever presses in extinction session 61.31.32.6-0.80.1-0.1-0.10.8-1.60.9-1.21.6-1.6-0.8-1.31.31.3-1.3
Bone: final force0.81.23.81.61.10.80.8-0.02.0-0.41.4-0.80.80.81.2-1.2-1.11.1
Bone: final moment0.71.23.31.51.10.90.90.11.8-0.41.3-0.80.80.71.2-1.2-1.11.1
Food consumed during 24 hour testing period0.10.21.2-0.6-0.20.30.30.1-0.30.6-0.70.2-0.2-1.10.0-0.0-0.10.1
Glucose0.81.23.81.51.81.91.91.41.01.00.2-0.30.3-0.60.2-0.2-0.00.0
Heart weight1.21.96.12.52.22.22.21.31.51.10.50.4-0.4-0.4-0.70.70.7-0.7
Delay discount hyperbolic model param2.22.44.3-0.9-1.9-1.2-1.2-2.00.6-1.50.7-2.12.10.41.8-1.8-1.81.8
Intermittent access intake day 1-15 change0.51.13.00.61.31.71.71.60.21.2-0.5-0.80.8-1.20.6-0.6-0.60.6
Intermittent access intake escalation0.61.12.90.91.61.71.71.70.41.1-0.2-0.80.8-0.80.7-0.7-0.70.7
Intermittent access intake escalation 21.71.95.5-0.41.11.91.92.2-1.02.2-1.80.1-0.1-2.3-0.20.20.3-0.3
Intermitt. access day 1 inactive lever presses0.10.52.61.60.60.60.6-0.41.40.00.70.0-0.00.2-0.70.70.7-0.7
Intermitt. access day 15 inactive lever presses0.20.31.00.90.51.01.00.20.80.40.20.3-0.3-0.50.1-0.1-0.00.0
Intermitt. access escalation Index1.82.64.91.30.1-0.5-0.5-1.21.9-1.92.2-1.91.91.91.7-1.7-1.81.8
Intermittent access day 1 total infusions0.30.41.5-0.3-0.1-0.7-0.7-0.1-0.6-0.2-0.11.2-1.20.5-0.70.70.7-0.7
Intermittent access day 15 total infusions0.20.31.10.81.00.80.80.80.40.30.2-0.10.1-0.00.2-0.2-0.20.2
Intermittent access terminal intake (last 3 days)0.40.61.80.41.21.31.31.3-0.11.0-0.50.1-0.1-0.80.1-0.1-0.00.0
Intermittent access total infusions0.10.10.30.20.50.40.40.6-0.10.3-0.10.3-0.3-0.1-0.10.10.2-0.2
Intermittent access day 1 locomotion1.21.54.90.50.80.10.10.7-0.60.4-0.22.2-2.20.4-1.61.61.6-1.6
Intermittent access day 15 total locomotion0.40.82.30.81.21.51.51.20.21.2-0.40.4-0.4-0.9-0.30.30.3-0.3
Intermittent access total locomotion0.50.61.60.30.70.50.50.9-0.60.8-0.51.3-1.3-0.3-0.80.80.9-0.9
Intermittent access standard deviation0.40.82.20.10.91.41.41.5-0.51.4-1.0-0.40.4-1.50.1-0.1-0.10.1
Left kidney weight1.78.114.13.63.53.83.82.81.02.9-0.62.8-2.8-1.6-2.82.82.9-2.9
Right kidney weight2.611.819.54.44.44.44.43.51.03.3-0.53.4-3.4-1.5-3.53.53.6-3.6
Cocaine induced anxiety1.11.63.81.00.30.60.60.2-0.20.7-0.31.9-1.9-0.4-1.81.81.9-1.9
Post-drug Anxiety1.11.22.41.50.21.11.1-0.10.60.8-0.10.9-0.9-0.8-1.51.51.5-1.5
Baseline Anxiety0.40.52.20.3-0.20.20.2-0.50.7-0.20.4-1.51.5-0.10.6-0.6-0.60.6
Tail length0.83.210.93.32.63.23.21.52.11.50.50.2-0.2-0.9-0.40.40.5-0.5
Length with tail0.41.87.62.82.42.02.01.11.60.60.90.3-0.30.3-0.20.20.3-0.3
Length without tail0.20.62.91.21.71.11.11.20.50.50.30.6-0.60.2-0.00.0-0.10.1
Times rat made contact with spout0.00.10.40.10.1-0.3-0.30.0-0.1-0.30.20.2-0.20.6-0.10.10.0-0.0
Lifetime Intake0.20.20.6-0.20.60.10.10.7-0.50.4-0.30.7-0.7-0.0-0.30.30.3-0.3
Liver weight, left1.22.07.72.82.51.61.60.72.4-0.11.70.0-0.01.00.4-0.4-0.50.5
Liver weight, right0.81.36.22.12.51.31.31.41.20.30.90.5-0.50.8-0.20.20.2-0.2
Locomotor activity0.30.40.9-0.8-0.7-0.6-0.6-0.5-0.70.2-0.70.9-0.9-0.5-0.70.70.6-0.6
Locomotor testing distance0.20.40.8-0.9-0.8-0.7-0.7-0.5-0.70.1-0.60.9-0.9-0.4-0.50.50.5-0.5
Locomotor testing rearing0.51.04.0-1.5-2.0-1.4-1.4-1.7-0.3-0.6-0.3-0.30.3-0.20.3-0.3-0.40.4
Locomotion in novel chamber0.10.10.30.50.60.20.20.20.6-0.20.5-0.40.40.50.2-0.2-0.20.2
Locomotion in novel chamber post-restriction0.50.82.81.71.21.51.51.01.00.60.4-0.40.4-0.30.2-0.2-0.20.2
Fecal boli incidents, locomotor time 10.40.52.0-1.2-0.4-0.4-0.40.7-1.40.6-1.10.6-0.6-0.6-0.40.40.4-0.4
Change in fecal boli incidents, locomotor task0.80.82.81.71.31.61.60.51.30.50.50.0-0.0-0.3-0.10.10.1-0.1
Time >=10cm from walls, locomotor time 10.40.41.4-0.1-0.20.10.1-0.30.6-0.20.2-1.21.2-0.10.8-0.8-0.80.8
Bouts of movement, locomotor time 11.82.08.1-2.8-2.3-1.9-1.9-0.6-2.3-0.2-1.40.8-0.8-0.5-0.10.10.1-0.1
Total resting periods, locomotor time 11.81.97.4-2.7-2.5-2.1-2.1-1.1-1.9-0.6-1.10.4-0.4-0.20.1-0.1-0.10.1
Rest time, locomotor task time 10.20.30.6-0.3-0.7-0.6-0.6-0.70.3-0.70.4-0.40.40.40.4-0.4-0.40.4
Distance moved, locomotor task time 10.30.41.0-0.10.1-0.6-0.6-0.30.0-0.80.7-0.80.81.00.7-0.7-0.70.7
Vertical activity count, locomotor time 10.20.61.20.50.40.20.2-0.20.8-0.50.8-1.11.10.61.0-1.0-1.01.0
Time >=10cm from walls, locomotor time 21.92.812.83.62.51.91.90.72.7-0.22.0-0.80.81.4-0.10.10.1-0.1
Bouts of movement, locomotor time 20.81.32.60.20.3-0.4-0.4-0.41.0-1.11.2-1.31.31.31.6-1.6-1.61.6
Total resting periods, locomotor time 20.81.42.90.10.2-0.4-0.4-0.40.9-1.21.2-1.31.31.31.7-1.7-1.71.7
Rest time, locomotor task time 21.31.66.2-2.5-2.4-1.7-1.7-1.1-1.6-0.2-1.20.4-0.4-0.8-0.10.10.1-0.1
Distance moved, locomotor task time 20.70.83.51.91.60.70.70.21.4-0.41.3-0.30.31.2-0.10.10.1-0.1
Vertical activity count, locomotor time 21.92.67.42.52.01.11.1-0.02.7-0.92.2-1.41.41.71.2-1.2-1.21.2
Light reinforcement 11.84.314.21.5-0.3-2.1-2.1-2.51.9-3.33.3-1.21.23.81.0-1.0-1.11.1
Light reinforcement 20.81.33.8-1.2-1.4-2.0-2.0-1.6-0.3-1.40.5-0.40.40.90.6-0.6-0.60.6
Bone: marrow area0.20.31.00.40.41.01.00.50.40.5-0.1-0.80.8-0.60.4-0.4-0.40.4
Bone: maximum diameter0.40.72.11.41.10.80.80.41.3-0.21.0-0.70.70.70.6-0.6-0.70.7
Bone: maximum force0.61.14.52.11.71.21.20.41.8-0.01.2-0.00.00.70.3-0.3-0.30.3
Bone: maximum moment0.50.93.81.91.61.21.20.51.60.01.00.0-0.00.60.3-0.3-0.30.3
Mean time between licks in bursts0.61.53.0-1.5-0.30.10.10.6-1.61.3-1.71.5-1.5-1.7-1.31.31.0-1.0
Mean num. licks in bursts0.20.31.11.00.2-0.2-0.2-0.30.4-0.50.80.0-0.00.9-0.60.60.5-0.5
Cd content in liver0.20.20.50.70.70.50.50.50.5-0.10.5-0.40.40.40.4-0.4-0.40.4
Co content in liver0.91.13.0-0.50.80.80.81.7-1.41.3-1.31.0-1.0-0.9-0.90.90.9-0.9
Cu content in liver0.20.20.6-0.5-0.70.30.3-0.0-0.10.4-0.5-0.40.4-0.70.5-0.5-0.50.5
Fe content in liver4.65.68.1-0.6-2.2-2.2-2.2-2.81.4-2.82.0-2.62.61.92.7-2.7-2.72.7
K content in liver0.20.20.70.40.40.90.90.50.40.6-0.2-0.00.0-0.50.1-0.1-0.10.1
Mg content in liver1.01.02.80.81.21.71.71.30.70.80.0-0.70.7-0.50.8-0.8-0.80.8
Mn content in liver0.60.72.91.71.51.11.10.81.00.30.60.2-0.20.3-0.30.30.3-0.3
Na content in liver0.20.31.4-0.7-1.2-0.4-0.4-0.9-0.0-0.0-0.4-0.20.2-0.60.2-0.2-0.20.2
Rb content in liver2.02.46.62.02.52.62.62.40.61.6-0.20.7-0.7-0.6-0.80.80.8-0.8
Se content in liver0.30.40.70.60.30.30.30.00.8-0.30.7-0.70.70.50.8-0.8-0.80.8
Sr content in liver0.60.50.8-0.60.1-0.1-0.10.2-0.80.6-0.80.9-0.9-0.7-0.90.90.9-0.9
Zn content in liver1.01.12.4-0.4-1.1-0.2-0.2-1.00.7-0.60.3-1.31.3-0.01.5-1.5-1.51.5
Bone: minimum diameter1.11.94.31.22.11.61.62.0-0.31.4-0.51.3-1.3-0.5-1.51.51.4-1.4
Time in familiar zone, hab. session 10.60.62.9-1.7-1.2-0.9-0.9-0.3-1.10.0-0.8-0.00.0-0.50.3-0.3-0.30.3
Time in novel zone, hab. session 11.01.04.62.11.51.11.10.41.7-0.31.4-0.60.60.90.2-0.2-0.20.2
Total zone transitions, hab. session 10.91.22.7-1.2-1.0-0.8-0.8-0.4-1.40.4-1.11.6-1.6-0.7-1.11.11.1-1.1
Total locomotion distance, hab. session 10.71.01.6-1.0-1.1-0.8-0.8-0.5-1.30.3-1.01.3-1.3-0.7-1.21.21.2-1.2
Locomotion velocity, hab. session 11.11.62.5-1.3-1.4-1.1-1.1-0.7-1.60.2-1.11.6-1.6-0.7-1.41.41.3-1.3
Time in familiar zone, hab. session 20.50.61.3-0.0-0.0-0.2-0.2-0.00.3-0.70.6-1.11.10.81.0-1.0-1.01.0
Time in novel zone, hab. session 20.70.81.20.81.00.80.80.60.10.8-0.31.1-1.1-0.5-1.11.11.1-1.1
Total zone transitions, hab. session 21.01.33.8-0.9-0.3-0.0-0.00.2-1.11.0-1.31.9-1.9-1.3-1.21.21.2-1.2
Total locomotion distance, hab. session 20.20.20.5-0.1-0.3-0.3-0.3-0.5-0.1-0.0-0.10.7-0.7-0.2-0.60.60.6-0.6
Locomotion velocity, hab. session 20.20.30.7-0.3-0.6-0.6-0.6-0.7-0.2-0.1-0.20.8-0.8-0.1-0.60.60.6-0.6
Novel to familiar place preference ratio0.60.62.61.60.90.40.4-0.11.3-0.61.3-0.60.61.10.1-0.1-0.10.1
Novelty place preference0.50.52.31.50.90.40.40.01.1-0.41.1-0.60.61.0-0.10.10.1-0.1
Time in novel zone, NPP test0.50.62.41.50.80.40.4-0.01.2-0.51.2-0.80.81.00.1-0.1-0.00.0
Total zone transitions, NPP test1.72.45.6-1.8-1.00.10.10.5-2.11.6-2.41.8-1.8-2.3-1.41.41.3-1.3
Total locomotion distance, NPP test2.12.85.2-1.0-0.40.60.60.8-1.81.9-2.21.9-1.9-2.3-2.02.02.0-2.0
Locomotion velocity, NPP test2.43.35.6-1.1-0.40.50.50.8-2.02.0-2.42.2-2.2-2.4-2.22.22.2-2.2
Intraocular pressure0.50.72.6-1.6-0.3-1.4-1.4-0.2-1.3-0.6-0.3-0.40.40.70.2-0.2-0.30.3
Delta distance traveled before/after self-admin0.60.61.0-0.2-0.7-0.8-0.8-0.80.1-1.00.6-0.80.80.90.9-0.9-0.90.9
Delta ambulatory time before/after self-admin0.91.12.2-0.3-1.2-1.3-1.3-1.50.2-1.50.9-0.90.91.20.9-0.9-1.01.0
Parametrial fat weight0.20.51.30.2-0.5-0.6-0.6-0.9-0.1-0.30.20.7-0.70.3-1.11.11.2-1.2
Pavlov. Cond. lever latency0.81.02.20.61.30.90.91.00.7-0.00.6-1.51.50.31.0-1.0-1.01.0
Pavlov. Cond. magazine entry latency1.11.44.61.0-1.0-1.3-1.3-2.21.3-1.81.7-0.10.11.70.2-0.2-0.20.2
Pavlov. Cond. change in total contacts0.20.21.30.4-0.9-0.1-0.1-1.10.6-0.10.10.4-0.4-0.4-0.10.10.2-0.2
Pavlov. Cond. index score0.70.93.0-0.2-1.5-1.4-1.4-1.70.0-1.00.50.8-0.80.7-0.30.30.4-0.4
Pavlov. Cond. latency score0.70.92.5-0.1-1.4-1.4-1.4-1.6-0.1-0.90.41.1-1.10.7-0.60.60.7-0.7
Pavlov. Cond. lever contacts0.80.92.4-0.6-1.5-1.2-1.2-1.3-0.5-0.3-0.31.2-1.2-0.1-0.90.90.9-0.9
Pavlov. Cond. magazine entry number0.70.82.6-1.00.60.90.91.6-1.21.3-1.4-0.20.2-1.3-0.10.10.1-0.1
Pavlov. Cond. intertrial magazine entries0.91.02.8-0.50.20.10.10.40.3-0.20.2-1.41.40.11.7-1.7-1.61.6
Pavlov. Cond. lever-magazine prob. diff.0.60.82.3-0.4-1.5-1.3-1.3-1.5-0.2-0.70.10.9-0.90.3-0.50.50.5-0.5
Pavlov. Cond. response bias0.60.73.60.0-1.5-1.1-1.1-1.90.6-1.10.70.2-0.20.50.1-0.1-0.10.1
Pavlov. Cond. lever latency1.92.67.6-2.4-1.20.10.10.7-2.51.8-2.81.0-1.0-2.6-1.21.21.1-1.1
Pavlov. Cond. magazine entry latency3.34.08.51.6-0.1-1.0-1.0-1.92.5-2.62.9-2.02.02.81.9-1.9-2.02.0
Pavlov. Cond. change in total contacts2.13.37.31.8-0.1-0.7-0.7-1.92.6-2.22.7-1.71.72.21.7-1.7-1.81.8
Pavlov. Cond. index score3.64.810.82.10.4-0.6-0.6-1.73.0-2.63.3-2.12.12.92.2-2.2-2.22.2
Pavlov. Cond. latency score2.83.78.41.90.4-0.5-0.5-1.52.8-2.32.9-1.91.92.51.9-1.9-2.02.0
Pavlov. Cond. lever contacts2.53.49.82.51.2-0.3-0.3-1.02.7-2.23.1-1.31.33.01.4-1.4-1.41.4
Pavlov. Cond. magazine entry number3.03.77.7-1.70.00.60.61.7-2.62.3-2.81.9-1.9-2.3-1.91.92.0-2.0
Pavlov. Cond. intertrial magazine entries1.32.03.0-0.41.00.90.91.7-1.51.7-1.61.6-1.6-1.3-1.51.51.6-1.6
Pavlov. Cond. lever-magazine prob. diff.3.34.410.02.00.3-0.7-0.7-1.72.9-2.53.2-2.02.02.82.1-2.1-2.12.1
Pavlov. Cond. response bias4.15.614.32.80.9-0.5-0.5-1.53.4-2.83.8-2.02.03.52.2-2.2-2.12.1
Time in closed arm before self-admin1.62.04.3-1.7-1.9-2.1-2.1-1.6-0.5-1.50.3-1.31.31.01.2-1.2-1.21.2
Time in closed arm after self-admin2.02.24.9-0.9-1.9-1.6-1.6-2.20.7-1.70.9-1.41.40.91.4-1.4-1.51.5
Time in open arm before self-admin0.20.20.90.41.00.30.30.70.10.10.10.4-0.40.3-0.30.30.3-0.3
Time in open arm after self-admin1.71.95.91.52.42.42.42.20.51.6-0.30.2-0.2-0.9-0.20.20.3-0.3
Bone: periosteal estimation0.30.51.81.11.31.21.21.00.70.50.2-0.20.2-0.00.2-0.2-0.20.2
Bone: periosteal perimeter0.40.72.21.11.51.21.21.20.30.7-0.00.6-0.6-0.1-0.60.60.6-0.6
Bone: post-yield work0.61.03.1-0.3-0.10.90.90.4-0.51.4-1.31.0-1.0-1.8-1.01.00.9-0.9
Progressive ratio test 1 active lever presses0.20.20.5-0.2-0.2-0.6-0.6-0.40.2-0.60.50.5-0.50.70.4-0.4-0.40.4
Progressive ratio test 1 breakpoint0.10.20.4-0.2-0.3-0.6-0.6-0.50.1-0.50.30.4-0.40.60.2-0.2-0.20.2
Progressive ratio test 1 inactive lever presses0.10.10.70.0-0.5-0.3-0.3-0.80.6-0.40.30.1-0.10.10.1-0.1-0.10.1
Progressive ratio test 2 active lever presses0.40.40.80.30.1-0.3-0.3-0.50.8-0.80.9-0.20.20.90.9-0.9-0.80.8
Progressive ratio test 2 breakpoint0.40.51.00.50.3-0.2-0.2-0.40.9-0.81.0-0.30.31.00.9-0.9-0.90.9
Progressive ratio test 2 inactive lever presses0.10.10.30.50.30.40.40.10.40.10.20.5-0.5-0.00.0-0.00.0-0.0
Incentive Sensitization - Responses0.00.10.30.10.50.20.20.40.10.00.10.3-0.30.20.2-0.2-0.20.2
Incentive Sensitization - Breakpoint0.10.10.20.20.50.10.10.30.2-0.20.30.2-0.20.40.3-0.3-0.30.3
Sum of active levers in priming session hrs 5-60.20.21.1-0.5-0.30.40.40.3-0.40.7-0.80.3-0.3-1.10.1-0.1-0.10.1
Progressive ratio0.20.30.7-0.2-0.3-0.5-0.5-0.80.6-0.70.6-0.10.10.50.5-0.5-0.50.5
Food seeking constrained by brief footshock0.10.10.40.1-0.10.20.20.00.10.2-0.10.6-0.6-0.2-0.50.50.4-0.4
Seeking ratio, punishment vs. effort0.00.00.10.1-0.00.10.10.3-0.20.2-0.10.2-0.2-0.1-0.20.20.2-0.2
Retroperitoneal fat weight1.04.119.44.42.81.31.3-0.03.3-1.23.3-0.30.32.80.1-0.1-0.00.0
Reaction time number correct1.12.17.21.92.12.72.71.71.41.30.1-0.40.4-0.90.6-0.6-0.40.4
Reaction time mean minus median0.10.21.11.00.80.40.40.10.7-0.30.7-0.00.00.60.2-0.2-0.20.2
Reaction time mean minus median AUC0.30.94.02.01.61.21.20.71.20.11.00.3-0.30.6-0.00.00.0-0.0
Reaction time num false alarms0.10.10.20.4-0.10.20.2-0.10.00.2-0.10.4-0.4-0.3-0.30.30.5-0.5
Reaction time num false alarms AUC0.10.10.30.2-0.5-0.1-0.1-0.60.3-0.30.3-0.20.20.10.3-0.3-0.10.1
Reaction time trials correct on left1.12.17.21.92.12.72.71.71.41.30.1-0.40.4-0.90.6-0.6-0.40.4
Reaction time trials on left1.12.07.01.92.12.62.61.61.51.30.2-0.50.5-0.80.6-0.6-0.40.4
Reaction time mean1.62.64.4-0.5-1.1-1.3-1.3-1.60.9-1.81.3-1.91.91.52.0-2.0-2.12.1
Reaction time mean AUC1.11.83.2-0.2-0.7-0.9-0.9-1.21.0-1.51.2-1.51.51.31.7-1.7-1.81.8
Median of all reaction times2.53.55.3-1.2-1.7-1.9-1.9-2.10.7-2.11.2-2.12.11.52.2-2.2-2.32.3
Reaction time omissions0.30.51.81.30.3-0.1-0.1-0.40.8-0.91.3-0.50.51.30.1-0.1-0.30.3
Reaction time false alarm rate0.40.61.9-0.6-1.3-1.4-1.4-1.1-0.4-0.90.2-0.00.00.6-0.10.10.1-0.1
Reaction time premature initiation rate1.92.68.1-0.5-2.1-2.4-2.4-2.80.5-2.31.4-1.11.11.60.7-0.7-0.70.7
Reaction time premature initiations0.81.53.40.5-0.9-0.9-0.9-1.91.3-1.51.4-1.41.41.11.1-1.1-1.01.0
Std. dev. reaction times0.51.02.51.20.80.00.0-0.21.2-1.11.5-0.60.61.61.0-1.0-1.11.1
Reaction time trials completed1.12.07.01.92.12.62.61.61.51.30.2-0.50.5-0.80.6-0.6-0.40.4
Reaction time trials AUC1.12.16.11.91.92.52.51.31.80.90.5-0.90.9-0.51.0-1.0-0.80.8
Run reversals in cocaine runway, females1.11.13.8-0.10.51.31.30.8-0.21.5-1.30.8-0.8-2.0-0.80.80.8-0.8
Run reversals in cocaine runway, males0.10.10.3-0.5-0.5-0.2-0.2-0.2-0.30.0-0.30.1-0.1-0.30.2-0.2-0.20.2
Latency to leave start box in cocaine runway0.70.81.30.4-0.5-0.5-0.5-1.01.2-1.11.1-1.01.00.81.0-1.0-1.01.0
Latency to leave start box in cocaine runway, F0.10.10.3-0.5-0.4-0.4-0.4-0.2-0.30.0-0.30.3-0.3-0.2-0.30.30.3-0.3
Latency to leave start box in cocaine runway, M4.03.87.11.7-0.4-0.1-0.1-1.82.7-2.02.5-2.32.31.82.2-2.2-2.22.2
Std. dev. time between licks in bursts1.01.32.70.91.61.11.11.5-0.31.0-0.41.5-1.5-0.2-1.31.31.2-1.2
Total sessions with >9 infusions0.80.93.8-0.80.1-1.0-1.00.2-1.0-0.2-0.32.0-2.00.7-0.70.70.7-0.7
Short access day 1 total inactive lever presses1.52.03.20.61.31.41.41.8-0.71.7-1.21.3-1.3-1.2-1.71.71.7-1.7
Short access day 10 total inactive lever presses0.41.02.71.40.11.61.6-0.11.21.1-0.3-0.10.1-1.6-0.80.80.8-0.8
Short access day 1 total infusions1.01.34.3-1.00.2-0.3-0.30.7-1.20.8-1.12.1-2.1-0.5-1.21.21.2-1.2
Short access day 10 total infusions0.30.41.0-0.5-0.3-1.0-1.0-0.4-0.5-0.60.20.8-0.80.8-0.30.30.4-0.4
Short access total infusions0.40.51.8-0.90.2-0.6-0.60.5-1.00.0-0.41.4-1.40.4-0.40.40.4-0.4
Short access day 1 locomotion0.50.61.8-1.2-0.7-1.3-1.3-0.5-0.8-0.6-0.21.0-1.00.6-0.20.20.2-0.2
Short access day 10 total locomotion2.85.211.00.11.91.51.52.8-1.92.4-1.93.3-3.3-1.5-2.52.52.5-2.5
Short access total locomotion1.41.76.00.00.9-0.2-0.21.0-1.10.5-0.52.4-2.40.4-1.61.61.6-1.6
One hour access (0.3 mA shock)0.91.12.50.10.61.11.10.70.60.4-0.0-1.11.1-0.61.6-1.6-1.51.5
Compulsive drug intake0.60.71.6-0.10.40.90.90.80.10.4-0.2-0.90.9-0.61.3-1.3-1.31.3
One hour access (shock baseline)0.20.30.80.4-0.1-0.5-0.5-0.60.5-0.80.8-0.50.50.90.4-0.4-0.40.4
Social response proportion5.15.810.41.4-1.5-1.2-1.2-3.12.8-2.82.9-3.23.22.22.3-2.3-2.22.2
Social responses5.47.011.30.0-2.2-2.3-2.3-3.31.9-3.42.7-3.13.12.62.8-2.8-2.62.6
Social time1.72.35.70.4-0.1-0.5-0.5-0.91.3-1.41.5-2.42.41.51.9-1.9-1.91.9
Soleus weight0.41.32.4-0.2-0.7-0.7-0.7-0.80.7-1.21.0-1.41.41.01.5-1.5-1.61.6
Bone: stiffness0.40.62.91.70.90.90.9-0.11.6-0.21.00.1-0.10.50.2-0.2-0.30.3
Tibialis anterior weight0.93.25.70.9-0.1-0.3-0.3-1.01.9-1.72.0-2.32.31.62.3-2.3-2.42.4
Time to tail flick, vehicle, before self-admin0.10.10.50.00.70.10.10.6-0.00.3-0.10.3-0.30.2-0.30.30.3-0.3
Time to tail flick, vehicle, after self-admin0.30.42.10.11.40.80.81.20.20.5-0.10.1-0.1-0.10.6-0.6-0.60.6
Time to tail flick, test, before self-admin0.30.30.8-0.1-0.3-0.7-0.7-0.50.1-0.80.6-0.50.50.90.4-0.4-0.50.5
Time to tail flick, test, after self-admin0.20.20.70.90.80.30.30.50.1-0.30.7-0.40.40.80.1-0.1-0.10.1
Delta time to tail flick, vehicle, before/after SA0.90.82.21.31.31.51.51.00.90.50.4-0.20.2-0.20.7-0.7-0.70.7
Delta time to tail flick, test, before/after SA0.10.10.30.30.50.10.10.4-0.1-0.00.20.2-0.20.4-0.10.10.2-0.2
Tibia length0.61.74.31.31.20.30.30.20.10.40.12.1-2.10.3-1.81.81.8-1.8
Ambulatory time before self-admin0.60.92.30.61.50.80.81.3-0.10.8-0.20.9-0.9-0.3-1.11.11.2-1.2
Ambulatory time after self-admin0.20.30.4-0.1-0.1-0.4-0.4-0.50.4-0.60.6-0.60.60.50.6-0.6-0.60.6
Bone: tissue strength0.80.81.50.40.50.80.80.6-0.31.0-0.71.0-1.0-1.0-1.21.21.2-1.2
Total heroin consumption1.41.73.3-1.2-0.20.10.10.7-1.31.4-1.71.8-1.8-1.5-1.41.41.4-1.4
Bone: trabecular number0.71.13.81.71.41.91.90.91.30.80.3-0.30.3-0.50.2-0.2-0.30.3
Bone: trabecular spacing0.91.24.0-0.8-0.9-2.0-2.0-1.0-0.6-1.70.8-0.10.11.70.1-0.1-0.10.1
Bone: trabecular thickness0.40.51.5-0.5-0.5-0.1-0.1-0.30.3-0.20.1-0.70.7-0.11.2-1.2-1.21.2
Bone: trabecular tissue density1.21.77.3-2.1-1.60.20.2-0.1-1.41.5-2.30.8-0.8-2.7-0.30.30.4-0.4
Water consumed over 24 hours1.11.42.5-0.7-0.8-1.2-1.2-1.20.6-1.30.9-1.21.21.11.6-1.6-1.51.5
Number of responses in last shaping day0.40.41.2-0.7-0.8-1.1-1.1-0.6-0.6-0.5-0.10.6-0.60.5-0.50.50.5-0.5