Diras3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Diras3	0.02	0.02	1.0e-03	0.02	0.03	0.02	0.02	1.7e-03	6.2e-04	1.8e-03	1.7e-03
2	BLA	gene expression	Diras3	0.05	0.04	1.6e-03	0.05	0.04	0.03	0.05	7.9e-04	2.1e-03	9.6e-03	1.2e-03
3	Adipose	gene expression	Diras3	0.15	0.1	0.0e+00	0.13	0.14	0.14	0.14	1.5e-14	6.1e-15	6.0e-15	4.8e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.1	0.2	-0.2	0.2	0.5
Area under the delay curve	0.1	0.1	0.1	-0.3	0.3	0.0
BMI with tail	2.1	6.9	8.5	-2.9	2.9	2.0
BMI without tail	0.5	1.0	1.6	-1.1	1.3	0.1
Body weight	0.1	0.5	1.1	0.6	-0.4	-1.1
Weight adjusted by age	0.1	0.1	0.1	0.1	-0.3	-0.4
Bone surface	0.0	0.0	0.1	-0.2	0.1	0.3
Bone volume	0.0	0.1	0.2	-0.2	0.1	0.4
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.0	-0.0	0.2
Number of licking bursts	0.2	0.3	0.6	0.3	-0.4	-0.8
Context. condit. distance diff. score	1.6	1.9	2.4	1.5	-1.5	-1.1
Locomotion velocity, session 1	0.3	0.3	0.5	0.5	-0.7	-0.4
Locomotion distance, session 1	0.4	0.5	0.9	-0.6	0.5	1.0
Locomotion velocity, session 2	0.1	0.1	0.3	-0.1	-0.0	0.5
Locomotion distance, session 2	0.4	0.5	0.8	-0.6	0.6	0.9
Locomotion velocity, session 3	0.2	0.3	0.6	-0.4	0.3	0.8
Locomotion distance, session 3	0.0	0.0	0.0	0.2	-0.1	-0.0
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.4	-0.6	-0.3
Stereotopy head waving duration, day 3	0.3	0.3	0.6	0.5	-0.8	-0.3
Locomotion velocity, session 7	0.6	0.7	1.2	-0.5	0.7	1.1
Locomotion distance, session 7	1.1	1.4	1.8	-1.0	1.2	1.3
Stereotopy head waving bouts, day 7	1.0	1.1	1.4	1.0	-1.2	-0.9
Stereotopy head waving duration, day 7	0.4	0.5	0.7	0.6	-0.8	-0.6
Locomotion velocity, session 8	0.1	0.1	0.2	0.4	-0.4	-0.1
Locomotion distance, session 8	0.1	0.1	0.3	-0.1	0.0	0.6
Degree of sensitization distance	0.2	0.2	0.2	-0.4	0.4	0.4
Degree of sensitization stereotypy	0.2	0.3	0.4	0.5	-0.6	-0.4
Conditioned locomotion	1.2	1.4	1.6	1.2	-1.3	-1.1
Cocaine response after cond. corrected	0.4	0.5	0.6	-0.7	0.8	0.5
Cocaine response after cond. not corrected	1.8	2.0	2.1	-1.4	1.5	1.3
Cocaine response before conditioning	2.7	3.2	3.7	-1.7	1.7	1.9
Saline control response	0.2	0.3	0.4	-0.5	0.5	0.7
Bone: connectivity density	0.0	0.0	0.1	0.2	-0.2	0.1
Bone: cortical apparent density	8.4	11.1	11.5	3.4	-3.4	-3.2
Bone: cortical area	1.2	1.8	1.9	1.3	-1.3	-1.4
Bone: cortical porosity	0.0	0.0	0.0	0.0	-0.1	0.2
Bone: cortical porosity	0.2	0.3	0.4	-0.5	0.4	0.6
Bone: cortical thickness	1.0	1.6	1.8	1.4	-1.3	-1.1
Bone: cortical thickness	0.8	1.0	1.0	1.0	-0.9	-1.0
Bone: cortical tissue density	8.6	11.3	11.7	3.4	-3.4	-3.2
Condit. Reinf. active minus inactive responses	0.5	0.6	0.8	-0.8	0.9	0.6
Condit. Reinf. active-inactive response ratio	2.4	2.6	2.8	-1.7	1.7	1.5
Condit. Reinf. active responses	0.2	0.3	0.3	-0.4	0.6	0.6
Condit. Reinf. inactive responses	1.7	2.0	2.4	1.5	-1.6	-1.2
Incentive salience index mean	0.4	0.5	0.5	-0.7	0.7	0.6
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.4	0.1	0.5
Condit. Reinf. active minus inactive responses	0.3	0.4	0.4	0.6	-0.7	-0.6
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.5	0.6	-0.7	-0.7
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	0.1	0.1
Condit. Reinf. inactive responses	0.6	0.8	0.9	-0.9	0.9	0.8
Condit. Reinf. lever presses	1.8	2.4	2.6	-1.5	1.5	1.6
Condit. Reinf. lever reinforcers received	0.0	0.0	0.0	-0.1	0.1	0.2
Conditioned reinforcement - actives	1.8	1.8	2.1	1.4	-1.4	-1.2
Conditioned reinforcement - inactives	0.3	0.3	0.4	0.6	-0.6	-0.4
Conditioned locomotion	0.9	1.0	1.4	-0.9	0.9	1.2
Patch foraging indifference point 0 sec	3.0	4.8	5.3	2.3	-2.3	-2.0
Patch foraging indifference point AUC	2.4	2.8	3.1	1.7	-1.8	-1.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.2	-0.2	-0.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.2	-0.0	0.1
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.3	0.3	0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.2	0.1	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.3	-0.2	-0.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.5	0.5	0.1
Indifference point function ln k	0.6	0.8	1.0	0.8	-0.9	-1.0
Indifference point function log k	0.6	0.8	1.0	0.8	-0.9	-1.0
Patch foraging total patch changes 0 sec	3.2	5.2	5.7	2.4	-2.4	-2.1
Patch foraging total patch changes 12 sec	3.1	4.0	4.6	2.1	-2.1	-1.7
Patch foraging total patch changes 18 sec	1.3	1.6	2.5	1.3	-1.6	-0.8
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.4	-0.4	-0.2
Patch foraging total patch changes 6 sec	1.8	2.7	2.8	1.7	-1.6	-1.6
Patch foraging time to switch 0 sec	10.6	16.4	17.3	-4.2	4.1	3.8
Patch foraging water rate 0 sec	17.6	28.2	30.6	5.5	-5.4	-5.0
Patch foraging water rate 12 sec	9.5	14.5	15.4	3.8	-3.7	-3.9
Patch foraging water rate 18 sec	4.8	6.5	6.9	2.6	-2.4	-2.6
Patch foraging water rate 24 sec	3.9	5.4	5.7	2.4	-2.3	-2.3
Patch foraging water rate 6 sec	4.2	6.2	6.9	2.6	-2.5	-2.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.6	0.6	-0.8	-0.4
Distance traveled before self-admin	0.0	0.0	0.1	-0.2	0.3	0.0
Distance traveled after self-admin	0.4	0.5	0.5	0.7	-0.7	-0.7
Extensor digitorum longus weight	6.2	24.3	25.6	4.8	-5.1	-4.9
Bone: elastic displacement	0.7	0.8	0.8	0.9	-0.9	-0.9
Bone: elastic work	0.2	0.2	0.2	0.4	-0.5	-0.5
Bone: endosteal estimation	0.1	0.2	0.4	-0.7	0.5	0.2
Bone: endosteal perimeter	0.0	0.1	0.2	-0.0	-0.0	-0.4
Epididymis fat weight	4.6	10.7	11.8	-3.3	3.4	3.1
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.2	0.3	0.0
Delta time in open arm before/after self-admin	0.6	0.6	0.8	0.7	-0.7	-0.9
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.2	-0.1	-0.1
Delay discount exponential model param	0.0	0.0	0.1	0.3	-0.2	0.1
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.0	0.0	0.3
Active lever presses in extinction session 6	1.1	1.1	1.3	1.1	-1.1	-0.9
Bone: final force	0.3	0.5	0.6	0.8	-0.6	-0.7
Bone: final moment	0.4	0.7	0.7	0.8	-0.7	-0.9
Food consumed during 24 hour testing period	0.1	0.1	0.1	0.4	-0.4	-0.4
Glucose	0.6	0.9	1.3	1.2	-0.9	-0.8
Heart weight	0.0	0.1	0.2	-0.1	0.4	0.1
Delay discount hyperbolic model param	0.0	0.1	0.1	0.3	-0.3	0.0
Intermittent access intake day 1-15 change	1.6	1.6	2.1	-1.1	1.1	1.5
Intermittent access intake escalation	1.9	1.9	2.6	-1.2	1.2	1.6
Intermittent access intake escalation 2	0.1	0.1	0.3	-0.3	0.2	0.5
Intermitt. access day 1 inactive lever presses	2.4	2.6	2.9	1.7	-1.6	-1.5
Intermitt. access day 15 inactive lever presses	0.7	0.8	0.9	1.0	-0.9	-0.8
Intermitt. access escalation Index	0.4	0.4	0.6	0.5	-0.4	-0.8
Intermittent access day 1 total infusions	0.4	0.4	0.5	-0.7	0.7	0.5
Intermittent access day 15 total infusions	2.0	2.3	2.6	-1.5	1.5	1.6
Intermittent access terminal intake (last 3 days)	2.2	2.4	2.4	-1.6	1.6	1.6
Intermittent access total infusions	0.9	1.0	1.0	-0.9	1.0	1.0
Intermittent access day 1 locomotion	1.0	1.0	1.1	-1.0	1.0	1.0
Intermittent access day 15 total locomotion	0.4	0.4	0.6	-0.6	0.6	0.8
Intermittent access total locomotion	0.6	0.6	0.8	-0.7	0.7	0.9
Intermittent access standard deviation	3.7	3.9	4.2	-1.9	1.9	2.1
Left kidney weight	0.6	1.7	2.1	1.3	-1.1	-1.4
Right kidney weight	0.3	0.7	1.0	0.8	-0.6	-1.0
Cocaine induced anxiety	3.1	3.5	3.6	1.9	-1.9	-1.9
Post-drug Anxiety	2.6	2.9	3.1	1.7	-1.7	-1.8
Baseline Anxiety	1.6	1.7	1.7	-1.3	1.3	1.3
Tail length	3.0	9.1	9.5	3.1	-2.9	-3.1
Length with tail	3.8	13.7	15.4	3.9	-3.7	-3.5
Length without tail	1.5	3.3	4.0	2.0	-2.0	-1.4
Times rat made contact with spout	0.3	0.3	0.5	0.6	-0.7	-0.4
Lifetime Intake	0.5	0.5	0.7	-0.7	0.7	0.8
Liver weight, left	3.6	5.7	6.7	2.3	-2.2	-2.6
Liver weight, right	0.0	0.1	0.2	0.1	-0.0	-0.4
Locomotor activity	0.0	0.0	0.1	0.3	-0.0	-0.1
Locomotor testing distance	0.1	0.2	0.5	0.7	-0.5	-0.2
Locomotor testing rearing	1.8	2.8	4.2	-1.5	1.4	2.1
Locomotion in novel chamber	5.3	6.5	7.9	2.6	-2.2	-2.8
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.3	0.0	-0.2
Fecal boli incidents, locomotor time 1	1.3	1.4	1.9	-1.4	1.2	0.8
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	-0.3	-0.4
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.5	-0.7	0.6	0.4
Bouts of movement, locomotor time 1	0.7	0.8	1.2	-1.1	0.7	0.9
Total resting periods, locomotor time 1	0.8	0.9	1.3	-1.1	0.8	0.9
Rest time, locomotor task time 1	0.5	0.5	1.0	0.5	-0.5	-1.0
Distance moved, locomotor task time 1	0.9	0.9	1.9	-0.6	0.7	1.4
Vertical activity count, locomotor time 1	0.4	0.4	0.6	0.8	-0.8	-0.1
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.6	0.8	-0.6	-0.7
Bouts of movement, locomotor time 2	2.4	2.6	3.1	1.5	-1.6	-1.8
Total resting periods, locomotor time 2	1.9	2.1	2.7	1.3	-1.4	-1.6
Rest time, locomotor task time 2	0.7	0.8	1.6	0.6	-0.6	-1.3
Distance moved, locomotor task time 2	0.8	0.9	2.0	-0.5	0.7	1.4
Vertical activity count, locomotor time 2	0.4	0.4	0.6	0.8	-0.8	0.0
Light reinforcement 1	0.0	0.1	0.1	-0.1	0.2	0.3
Light reinforcement 2	1.3	1.7	1.9	-1.4	1.4	1.2
Bone: marrow area	0.1	0.2	0.4	-0.6	0.4	0.1
Bone: maximum diameter	0.1	0.3	0.5	0.3	-0.4	-0.7
Bone: maximum force	0.4	0.6	0.7	0.8	-0.7	-0.8
Bone: maximum moment	0.3	0.6	0.7	0.7	-0.7	-0.8
Mean time between licks in bursts	0.9	1.2	1.4	-1.2	1.2	1.0
Mean num. licks in bursts	0.1	0.1	0.3	0.0	-0.0	0.6
Cd content in liver	0.4	0.4	0.6	0.6	-0.3	-0.8
Co content in liver	0.7	0.9	1.1	1.0	-1.0	-0.8
Cu content in liver	0.9	1.1	1.6	-1.1	1.3	0.7
Fe content in liver	0.1	0.2	0.3	-0.3	0.6	0.2
K content in liver	0.1	0.1	0.2	0.3	-0.5	-0.2
Mg content in liver	0.1	0.1	0.3	0.2	-0.6	-0.1
Mn content in liver	0.1	0.1	0.1	0.1	-0.3	0.3
Na content in liver	0.0	0.0	0.0	-0.1	0.0	0.1
Rb content in liver	0.6	0.7	0.8	0.9	-0.8	-0.8
Se content in liver	0.1	0.1	0.1	-0.2	0.1	-0.3
Sr content in liver	0.4	0.3	0.5	0.5	-0.4	-0.7
Zn content in liver	0.3	0.3	0.6	0.5	-0.8	-0.5
Bone: minimum diameter	0.7	1.3	1.6	1.1	-1.1	-1.3
Time in familiar zone, hab. session 1	1.0	0.9	1.8	-0.8	0.7	1.3
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.2	0.1	-0.4
Total zone transitions, hab. session 1	0.6	0.9	1.3	-0.9	0.8	1.1
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.0	0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.6	0.8	-0.7	-0.4
Time in familiar zone, hab. session 2	0.9	1.0	1.5	-0.8	0.9	1.2
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	0.0	-0.4
Total zone transitions, hab. session 2	0.7	0.9	1.2	-0.9	0.9	1.1
Total locomotion distance, hab. session 2	0.3	0.4	0.6	0.7	-0.6	-0.6
Locomotion velocity, hab. session 2	0.5	0.6	0.8	0.9	-0.8	-0.6
Novel to familiar place preference ratio	0.2	0.2	0.3	-0.5	0.5	0.3
Novelty place preference	0.1	0.1	0.2	-0.4	0.4	0.2
Time in novel zone, NPP test	0.1	0.1	0.1	-0.4	0.4	0.2
Total zone transitions, NPP test	0.1	0.2	0.3	-0.4	0.2	0.5
Total locomotion distance, NPP test	0.0	0.0	0.0	0.2	-0.2	-0.2
Locomotion velocity, NPP test	0.0	0.1	0.1	0.3	-0.3	-0.2
Intraocular pressure	0.1	0.1	0.2	-0.3	0.2	0.4
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	-0.2	0.2
Delta ambulatory time before/after self-admin	0.4	0.5	0.7	0.8	-0.9	-0.3
Parametrial fat weight	0.0	0.0	0.1	0.0	0.1	-0.4
Pavlov. Cond. lever latency	0.6	0.8	0.9	0.9	-0.8	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.6	1.0	-0.8	0.5	1.0
Pavlov. Cond. change in total contacts	0.4	0.4	0.8	-0.6	0.4	0.9
Pavlov. Cond. index score	0.8	1.0	1.2	-1.1	0.8	1.1
Pavlov. Cond. latency score	0.5	0.6	0.8	-0.9	0.6	0.9
Pavlov. Cond. lever contacts	0.7	0.9	1.0	-1.0	0.8	1.0
Pavlov. Cond. magazine entry number	1.0	1.2	1.4	1.2	-0.9	-1.2
Pavlov. Cond. intertrial magazine entries	5.1	6.2	6.7	2.6	-2.3	-2.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	0.8	-0.9	0.6	0.9
Pavlov. Cond. response bias	1.1	1.4	1.8	-1.2	0.9	1.4
Pavlov. Cond. lever latency	2.5	3.4	4.1	1.8	-1.7	-2.0
Pavlov. Cond. magazine entry latency	5.2	6.0	6.5	-2.5	2.5	2.3
Pavlov. Cond. change in total contacts	4.2	5.8	6.2	-2.4	2.5	2.3
Pavlov. Cond. index score	5.5	7.1	7.3	-2.6	2.7	2.7
Pavlov. Cond. latency score	5.4	6.7	7.0	-2.6	2.6	2.6
Pavlov. Cond. lever contacts	3.2	4.4	4.8	-2.1	2.0	2.2
Pavlov. Cond. magazine entry number	4.1	5.1	5.6	2.3	-2.4	-2.1
Pavlov. Cond. intertrial magazine entries	4.8	6.2	7.3	2.6	-2.7	-2.1
Pavlov. Cond. lever-magazine prob. diff.	6.2	7.8	8.0	-2.8	2.8	2.8
Pavlov. Cond. response bias	4.3	5.8	5.8	-2.4	2.4	2.4
Time in closed arm before self-admin	2.9	3.3	3.6	-1.9	1.8	1.7
Time in closed arm after self-admin	1.6	1.6	1.8	-1.4	1.3	1.1
Time in open arm before self-admin	5.0	5.4	5.6	2.4	-2.3	-2.3
Time in open arm after self-admin	3.2	3.6	3.9	1.9	-1.8	-2.0
Bone: periosteal estimation	0.2	0.4	0.8	0.5	-0.6	-0.9
Bone: periosteal perimeter	0.1	0.2	0.5	0.3	-0.3	-0.7
Bone: post-yield work	1.1	1.5	1.6	1.3	-1.1	-1.3
Progressive ratio test 1 active lever presses	0.0	0.1	0.1	-0.2	0.2	0.3
Progressive ratio test 1 breakpoint	0.2	0.2	0.2	-0.3	0.4	0.5
Progressive ratio test 1 inactive lever presses	2.4	2.7	3.1	1.7	-1.7	-1.4
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	0.2	0.3
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.1	0.2	0.3
Progressive ratio test 2 inactive lever presses	0.7	0.8	1.0	1.0	-0.9	-0.7
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.1	0.2	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.0	0.1	0.1
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	-0.4	0.4	0.9
Progressive ratio	0.3	0.4	0.5	0.7	-0.5	-0.6
Food seeking constrained by brief footshock	1.6	2.0	2.4	1.5	-1.4	-1.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.3	-0.3	-0.1
Retroperitoneal fat weight	0.2	0.6	0.9	-0.8	1.0	0.4
Reaction time number correct	2.7	3.9	4.3	2.1	-2.1	-1.8
Reaction time mean minus median	0.1	0.1	0.2	-0.4	0.4	-0.2
Reaction time mean minus median AUC	0.1	0.1	0.2	-0.4	0.4	-0.2
Reaction time num false alarms	0.7	1.0	1.1	1.1	-1.1	-0.9
Reaction time num false alarms AUC	1.3	1.8	2.0	1.4	-1.4	-1.3
Reaction time trials correct on left	2.7	3.9	4.3	2.1	-2.1	-1.8
Reaction time trials on left	2.7	3.9	4.3	2.1	-2.1	-1.8
Reaction time mean	0.8	1.1	1.3	-1.1	1.1	0.8
Reaction time mean AUC	0.5	0.7	0.9	-0.9	0.9	0.5
Median of all reaction times	0.5	0.7	0.8	-0.9	0.9	0.7
Reaction time omissions	1.1	1.5	1.9	1.1	-1.2	-1.4
Reaction time false alarm rate	0.1	0.1	0.2	0.3	-0.3	-0.4
Reaction time premature initiation rate	0.7	0.9	1.1	1.0	-1.1	-0.8
Reaction time premature initiations	2.2	3.2	3.8	1.8	-2.0	-1.5
Std. dev. reaction times	0.2	0.3	0.5	-0.7	0.7	0.0
Reaction time trials completed	2.7	3.9	4.3	2.1	-2.1	-1.8
Reaction time trials AUC	2.9	4.2	4.6	2.1	-2.1	-1.9
Run reversals in cocaine runway, females	1.1	1.0	1.2	-1.0	1.1	0.9
Run reversals in cocaine runway, males	1.3	1.3	2.0	1.0	-1.4	-0.9
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.4	0.2	0.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.4	0.2	0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.1	0.3
Std. dev. time between licks in bursts	0.7	0.9	0.9	-0.9	0.9	0.9
Total sessions with >9 infusions	0.2	0.2	0.6	-0.3	0.2	0.8
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.2	0.4	0.4
Short access day 10 total inactive lever presses	0.4	0.5	0.6	0.7	-0.6	-0.8
Short access day 1 total infusions	0.1	0.2	0.2	0.5	-0.4	-0.3
Short access day 10 total infusions	0.5	0.5	0.6	-0.7	0.8	0.7
Short access total infusions	0.3	0.3	0.4	-0.5	0.5	0.7
Short access day 1 locomotion	0.9	0.9	1.1	-0.9	1.0	1.0
Short access day 10 total locomotion	0.7	0.8	1.0	-0.8	0.9	1.0
Short access total locomotion	0.1	0.1	0.2	-0.3	0.3	0.4
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.3	-0.2	-0.1
Compulsive drug intake	0.0	0.0	0.0	-0.1	0.2	0.2
One hour access (shock baseline)	0.0	0.0	0.1	-0.1	0.1	0.3
Social response proportion	0.2	0.3	0.3	0.5	-0.5	-0.5
Social responses	0.2	0.2	0.5	-0.2	0.2	0.7
Social time	0.9	1.2	1.4	1.0	-1.0	-1.2
Soleus weight	0.0	0.0	0.1	-0.2	0.1	0.3
Bone: stiffness	1.7	2.7	2.9	1.7	-1.5	-1.7
Tibialis anterior weight	0.4	1.2	1.3	1.0	-1.2	-1.1
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.6	0.8	-0.7	-0.7
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.4	-0.5	0.4	0.6
Time to tail flick, test, before self-admin	0.1	0.0	0.1	0.2	-0.3	-0.0
Time to tail flick, test, after self-admin	1.9	2.0	2.4	1.3	-1.3	-1.5
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.3	0.3	0.5
Delta time to tail flick, test, before/after SA	1.2	1.1	1.6	1.0	-0.9	-1.2
Tibia length	0.6	1.7	2.1	1.1	-1.3	-1.5
Ambulatory time before self-admin	0.1	0.1	0.2	-0.3	0.4	-0.1
Ambulatory time after self-admin	0.0	0.0	0.1	-0.1	0.1	0.3
Bone: tissue strength	0.2	0.2	0.3	0.4	-0.3	-0.6
Total heroin consumption	1.1	1.3	1.6	1.2	-1.2	-0.9
Bone: trabecular number	0.0	0.0	0.0	0.2	-0.1	0.1
Bone: trabecular spacing	0.0	0.0	0.1	-0.2	0.1	-0.2
Bone: trabecular thickness	0.1	0.1	0.1	0.4	-0.4	-0.2
Bone: trabecular tissue density	0.2	0.2	0.3	0.6	-0.4	-0.4
Water consumed over 24 hours	3.1	3.7	4.3	2.0	-2.1	-1.7
Number of responses in last shaping day	0.3	0.3	0.4	-0.6	0.5	0.3