Depdc7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Depdc7	0.02	0.02	9.0e-03	0	0	-0	0	1.3e-01	2.7e-01	9.4e-01	3.5e-01
2	pVTA	gene expression	Depdc7	0.06	0.05	5.9e-03	0.02	0.04	0.02	0.02	5.3e-02	6.2e-03	4.4e-02	4.1e-02
3	Brain	intron excision ratio	chr3_91101172_91101314	0.02	0.02	9.9e-03	0	-0	-0	-0	3.4e-01	8.7e-01	9.5e-01	8.7e-01
4	Adipose	mRNA stability	Depdc7	0.1	0.07	9.1e-13	0.09	0.09	0.09	0.09	2.7e-10	3.2e-10	3.3e-10	3.2e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
Bone: apparent density	0.6	0.9	1.2	0.8	-1.1	-1.0	0.9
Area under the delay curve	0.3	0.4	0.5	-0.5	0.6	0.6	-0.7
BMI with tail	0.3	0.8	0.9	1.0	-0.9	-0.9	0.9
BMI without tail	0.3	0.5	0.6	0.7	-0.8	-0.7	0.7
Body weight	1.2	4.9	6.0	2.0	-2.0	-2.5	2.4
Weight adjusted by age	0.2	0.2	0.4	0.1	0.3	0.6	-0.6
Bone surface	0.3	0.6	0.7	0.6	-0.8	-0.8	0.8
Bone volume	0.7	1.3	1.5	1.0	-1.2	-1.2	1.1
Breakpoint value in progressive ratio session	0.8	0.8	1.5	-1.2	1.0	0.7	-0.6
Number of licking bursts	0.2	0.2	0.4	0.7	-0.5	0.0	-0.0
Context. condit. distance diff. score	4.7	5.6	5.8	2.3	-2.4	-2.4	2.4
Locomotion velocity, session 1	1.5	1.6	1.7	-1.3	1.3	1.3	-1.3
Locomotion distance, session 1	0.3	0.4	0.5	-0.4	0.5	0.7	-0.7
Locomotion velocity, session 2	0.0	0.0	0.0	0.1	0.1	0.2	-0.1
Locomotion distance, session 2	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2
Locomotion velocity, session 3	0.1	0.1	0.1	0.3	-0.2	0.2	-0.3
Locomotion distance, session 3	0.1	0.1	0.1	0.2	-0.2	0.3	-0.3
Stereotopy head waving bouts, day 3	0.3	0.3	0.5	-0.3	0.5	0.6	-0.7
Stereotopy head waving duration, day 3	0.3	0.3	0.4	0.6	-0.5	-0.7	0.6
Locomotion velocity, session 7	0.1	0.1	0.2	0.3	-0.3	-0.4	0.4
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	0.3	0.2	-0.1
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.0	0.1	0.3	-0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.1	-0.2	0.2	0.3	-0.4
Locomotion velocity, session 8	0.3	0.4	0.6	0.5	-0.6	-0.7	0.8
Locomotion distance, session 8	2.9	4.3	4.7	2.0	-2.2	-2.1	2.1
Degree of sensitization distance	0.2	0.2	0.3	-0.6	0.4	-0.4	0.5
Degree of sensitization stereotypy	0.4	0.4	0.6	-0.5	0.5	0.7	-0.8
Conditioned locomotion	6.7	7.8	8.8	-2.5	2.8	2.9	-3.0
Cocaine response after cond. corrected	3.1	3.5	4.3	-2.0	2.1	1.7	-1.7
Cocaine response after cond. not corrected	0.6	0.7	1.0	-1.0	1.0	0.6	-0.6
Cocaine response before conditioning	6.4	7.8	8.2	2.7	-2.9	-2.8	2.8
Saline control response	0.1	0.1	0.2	0.4	-0.3	-0.1	0.1
Bone: connectivity density	0.7	1.0	1.3	0.9	-1.1	-1.0	1.0
Bone: cortical apparent density	0.0	0.0	0.0	0.0	-0.2	-0.2	0.2
Bone: cortical area	0.6	0.9	1.1	0.9	-0.9	-1.0	1.1
Bone: cortical porosity	0.6	0.6	0.8	-0.8	0.9	0.7	-0.7
Bone: cortical porosity	0.1	0.1	0.1	-0.4	0.4	0.2	-0.2
Bone: cortical thickness	0.1	0.1	0.2	0.2	-0.2	-0.4	0.4
Bone: cortical thickness	1.3	1.5	1.6	-1.1	1.2	1.2	-1.3
Bone: cortical tissue density	0.0	0.0	0.1	0.0	-0.2	-0.2	0.2
Condit. Reinf. active minus inactive responses	2.4	2.7	2.8	1.6	-1.7	-1.7	1.6
Condit. Reinf. active-inactive response ratio	6.8	7.4	7.6	2.7	-2.7	-2.7	2.7
Condit. Reinf. active responses	0.4	0.5	0.6	0.7	-0.7	-0.7	0.7
Condit. Reinf. inactive responses	1.9	2.2	2.8	-1.7	1.6	1.4	-1.3
Incentive salience index mean	1.7	2.1	2.3	1.4	-1.4	-1.5	1.5
Condit. Reinf. lever presses	0.6	0.9	1.1	0.8	-0.9	-1.0	1.0
Condit. Reinf. active minus inactive responses	2.6	3.2	3.5	1.7	-1.7	-1.8	1.9
Condit. Reinf. active-inactive response ratio	6.0	6.3	6.5	2.5	-2.5	-2.5	2.6
Condit. Reinf. active responses	1.6	2.2	2.4	1.5	-1.4	-1.5	1.5
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	0.1	0.2	-0.2
Condit. Reinf. lever presses	1.5	2.0	2.0	1.4	-1.4	-1.4	1.4
Condit. Reinf. lever reinforcers received	1.6	2.2	2.3	1.5	-1.4	-1.5	1.5
Conditioned reinforcement - actives	7.0	7.0	8.2	2.9	-2.7	-2.6	2.4
Conditioned reinforcement - inactives	11.5	12.9	17.8	4.2	-4.1	-2.9	2.9
Conditioned locomotion	3.7	4.5	6.2	2.5	-2.2	-1.8	1.8
Patch foraging indifference point 0 sec	0.5	0.8	1.8	0.0	0.4	1.2	-1.3
Patch foraging indifference point AUC	1.0	1.1	1.3	-1.2	1.1	1.0	-0.9
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.2	-0.2	0.0	0.1
Delay disc. indifference point, 16s delay	0.8	0.8	1.1	-0.8	0.9	0.9	-1.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.4	-0.3	-0.3	0.2
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	-0.7	0.7	0.2	-0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	-0.6	0.6	0.3	-0.4
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.0	0.0	-0.3	0.1
Indifference point function ln k	0.7	0.9	1.0	0.9	-0.9	-1.0	1.0
Indifference point function log k	0.7	0.9	1.0	0.9	-0.9	-1.0	1.0
Patch foraging total patch changes 0 sec	0.5	0.8	1.7	-0.0	0.3	1.2	-1.3
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	0.7	-0.5	-0.3	0.2
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	-0.1	0.3	0.7	-0.7
Patch foraging total patch changes 24 sec	0.4	0.5	1.0	-0.2	0.4	0.9	-1.0
Patch foraging total patch changes 6 sec	0.4	0.5	1.0	-0.1	0.3	1.0	-1.0
Patch foraging time to switch 0 sec	0.3	0.5	0.8	0.9	-0.7	-0.6	0.6
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1
Patch foraging water rate 12 sec	0.0	0.0	0.0	-0.2	0.1	-0.1	0.1
Patch foraging water rate 18 sec	0.4	0.6	0.6	0.8	-0.7	-0.8	0.7
Patch foraging water rate 24 sec	0.1	0.2	0.3	0.2	-0.3	-0.5	0.5
Patch foraging water rate 6 sec	0.0	0.0	0.1	-0.3	0.1	0.0	-0.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.5	0.4	-0.6	-0.7	0.4
Distance traveled before self-admin	0.4	0.4	0.9	0.4	-0.6	-1.0	0.6
Distance traveled after self-admin	1.8	2.0	3.2	1.0	-1.0	-1.8	1.7
Extensor digitorum longus weight	0.1	0.5	0.7	-0.8	0.8	0.6	-0.6
Bone: elastic displacement	0.5	0.6	0.9	-1.0	0.8	0.7	-0.6
Bone: elastic work	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2
Bone: endosteal estimation	0.1	0.2	0.2	-0.3	0.4	0.4	-0.5
Bone: endosteal perimeter	0.1	0.3	0.5	0.7	-0.6	-0.4	0.5
Epididymis fat weight	1.4	3.2	3.6	1.9	-1.9	-1.7	1.7
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.0	0.1	0.3	-0.3
Delta time in open arm before/after self-admin	1.1	1.0	1.5	-1.2	1.2	0.8	-0.8
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.1	-0.2	-0.5	0.2
Delay discount exponential model param	0.4	0.5	0.6	0.6	-0.7	-0.6	0.7
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.0	-0.3	-0.3	0.5
Active lever presses in extinction session 6	0.5	0.5	0.8	0.9	-0.8	-0.4	0.7
Bone: final force	0.1	0.2	0.3	0.3	-0.5	-0.5	0.5
Bone: final moment	0.1	0.1	0.1	0.1	-0.3	-0.3	0.4
Food consumed during 24 hour testing period	4.7	5.7	6.5	2.2	-2.3	-2.5	2.5
Glucose	1.5	2.3	2.9	1.2	-1.5	-1.7	1.7
Heart weight	0.3	0.5	0.7	-0.8	0.6	0.7	-0.6
Delay discount hyperbolic model param	0.3	0.3	0.3	0.5	-0.6	-0.4	0.6
Intermittent access intake day 1-15 change	0.6	0.6	1.1	1.0	-0.8	-0.5	0.5
Intermittent access intake escalation	0.6	0.6	1.2	1.1	-0.9	-0.5	0.5
Intermittent access intake escalation 2	1.1	1.0	1.3	1.1	-1.1	-0.9	1.0
Intermitt. access day 1 inactive lever presses	2.9	3.1	3.8	1.9	-1.9	-1.8	1.4
Intermitt. access day 15 inactive lever presses	5.6	6.1	7.1	2.3	-2.4	-2.7	2.5
Intermitt. access escalation Index	0.1	0.1	0.3	-0.5	0.5	-0.0	0.1
Intermittent access day 1 total infusions	3.3	3.8	4.4	1.9	-1.8	-2.1	1.9
Intermittent access day 15 total infusions	4.3	4.9	5.9	2.4	-2.2	-2.1	2.0
Intermittent access terminal intake (last 3 days)	4.2	4.6	5.5	2.3	-2.2	-2.0	2.0
Intermittent access total infusions	4.9	5.4	5.8	2.4	-2.3	-2.3	2.2
Intermittent access day 1 locomotion	1.9	2.0	3.0	1.7	-1.5	-1.4	1.1
Intermittent access day 15 total locomotion	0.5	0.5	1.3	1.1	-0.8	-0.1	0.1
Intermittent access total locomotion	2.0	2.2	3.9	2.0	-1.7	-1.2	0.9
Intermittent access standard deviation	2.5	2.6	3.2	1.7	-1.8	-1.5	1.5
Left kidney weight	1.2	3.4	3.9	1.7	-1.8	-2.0	2.0
Right kidney weight	1.0	2.7	2.8	1.7	-1.6	-1.7	1.7
Cocaine induced anxiety	2.2	2.5	3.1	1.8	-1.7	-1.4	1.4
Post-drug Anxiety	0.5	0.5	0.6	0.8	-0.7	-0.8	0.7
Baseline Anxiety	4.8	5.1	6.0	-2.4	2.5	2.1	-2.1
Tail length	0.3	1.0	1.5	0.5	-0.8	-1.2	1.2
Length with tail	0.8	2.9	4.1	1.3	-1.4	-2.0	2.0
Length without tail	1.0	2.3	2.9	1.4	-1.3	-1.7	1.6
Times rat made contact with spout	0.2	0.3	0.4	0.6	-0.5	-0.4	0.4
Lifetime Intake	4.7	5.4	5.6	2.4	-2.3	-2.3	2.3
Liver weight, left	1.3	2.1	2.8	1.1	-1.3	-1.6	1.7
Liver weight, right	3.2	5.4	6.3	2.1	-2.2	-2.5	2.5
Locomotor activity	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1
Locomotor testing distance	1.8	3.0	3.6	1.6	-1.6	-1.9	1.9
Locomotor testing rearing	0.7	1.1	1.4	1.0	-0.9	-1.2	1.1
Locomotion in novel chamber	0.3	0.4	0.5	0.7	-0.6	-0.6	0.6
Locomotion in novel chamber post-restriction	1.7	2.1	2.3	-1.5	1.3	1.4	-1.5
Fecal boli incidents, locomotor time 1	5.8	6.3	7.7	-2.8	2.7	2.2	-2.3
Change in fecal boli incidents, locomotor task	1.8	1.7	2.1	1.5	-1.4	-1.2	1.2
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.1	-1.0	0.8	0.7	-0.6
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.1	0.1	-0.7	0.5
Total resting periods, locomotor time 1	0.1	0.2	0.2	-0.4	0.3	-0.5	0.4
Rest time, locomotor task time 1	1.4	1.5	2.8	-1.7	1.4	0.8	-0.8
Distance moved, locomotor task time 1	2.4	2.6	2.8	1.6	-1.7	-1.5	1.6
Vertical activity count, locomotor time 1	0.3	0.3	0.6	0.7	-0.7	-0.3	0.4
Time >=10cm from walls, locomotor time 2	3.6	3.8	4.6	1.7	-1.9	-2.1	2.1
Bouts of movement, locomotor time 2	1.7	1.8	2.2	1.5	-1.4	-1.3	1.3
Total resting periods, locomotor time 2	1.6	1.7	2.1	1.4	-1.4	-1.2	1.2
Rest time, locomotor task time 2	3.7	4.3	4.7	-2.0	2.0	2.2	-2.2
Distance moved, locomotor task time 2	4.5	5.3	7.2	1.7	-2.0	-2.6	2.7
Vertical activity count, locomotor time 2	4.0	4.3	4.9	1.9	-2.0	-2.2	2.2
Light reinforcement 1	0.1	0.1	0.1	0.3	-0.3	-0.3	0.3
Light reinforcement 2	0.3	0.5	1.0	-1.0	0.8	0.4	-0.4
Bone: marrow area	0.1	0.2	0.2	-0.3	0.4	0.4	-0.5
Bone: maximum diameter	0.3	0.5	0.6	0.7	-0.6	-0.7	0.8
Bone: maximum force	0.2	0.3	0.5	0.7	-0.6	-0.4	0.3
Bone: maximum moment	0.0	0.1	0.2	0.4	-0.3	-0.1	0.1
Mean time between licks in bursts	0.5	0.7	1.1	-0.5	0.7	1.0	-1.0
Mean num. licks in bursts	0.1	0.1	0.2	-0.2	0.1	-0.4	0.4
Cd content in liver	0.2	0.3	0.4	0.4	-0.5	-0.6	0.6
Co content in liver	1.2	1.4	1.9	-1.4	1.3	1.0	-1.0
Cu content in liver	0.7	0.9	1.3	-1.1	1.1	0.7	-0.8
Fe content in liver	0.1	0.1	0.2	-0.5	0.4	0.1	-0.2
K content in liver	1.3	1.3	1.8	-0.8	0.9	1.3	-1.3
Mg content in liver	0.8	0.8	1.0	-0.8	0.8	1.0	-1.0
Mn content in liver	1.8	2.1	2.8	-1.3	1.2	1.7	-1.6
Na content in liver	0.1	0.1	0.2	0.5	-0.5	-0.2	0.2
Rb content in liver	0.8	0.9	1.4	-1.2	1.1	0.8	-0.8
Se content in liver	3.8	4.6	5.1	-2.1	2.3	2.1	-2.1
Sr content in liver	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1
Zn content in liver	0.9	1.0	1.6	-1.3	1.1	0.8	-0.8
Bone: minimum diameter	1.3	2.4	2.7	1.5	-1.5	-1.6	1.6
Time in familiar zone, hab. session 1	1.0	0.9	1.1	-1.0	1.0	0.9	-0.9
Time in novel zone, hab. session 1	1.7	1.7	1.9	1.4	-1.4	-1.2	1.2
Total zone transitions, hab. session 1	1.4	1.9	2.7	1.6	-1.6	-1.1	1.1
Total locomotion distance, hab. session 1	0.2	0.2	0.6	0.8	-0.6	0.1	-0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.6	-0.4	0.3	-0.4
Time in familiar zone, hab. session 2	0.5	0.5	0.7	-0.4	0.5	0.8	-0.8
Time in novel zone, hab. session 2	0.6	0.6	0.9	0.4	-0.5	-0.9	1.0
Total zone transitions, hab. session 2	0.5	0.6	0.8	0.8	-0.9	-0.7	0.7
Total locomotion distance, hab. session 2	0.7	0.9	1.3	-0.8	0.8	1.1	-1.2
Locomotion velocity, hab. session 2	0.6	0.9	1.3	-0.6	0.7	1.1	-1.1
Novel to familiar place preference ratio	2.6	2.6	3.8	1.9	-1.8	-1.4	1.3
Novelty place preference	3.0	3.0	4.1	2.0	-1.8	-1.5	1.5
Time in novel zone, NPP test	2.5	2.6	3.3	1.8	-1.7	-1.4	1.4
Total zone transitions, NPP test	1.8	2.5	2.6	-1.6	1.5	1.6	-1.6
Total locomotion distance, NPP test	2.6	3.6	4.0	-1.7	1.8	2.0	-2.0
Locomotion velocity, NPP test	2.3	3.2	3.7	-1.6	1.7	1.9	-1.9
Intraocular pressure	0.5	0.7	1.0	-0.7	0.6	1.0	-0.9
Delta distance traveled before/after self-admin	0.2	0.2	0.4	0.2	-0.1	-0.4	0.6
Delta ambulatory time before/after self-admin	0.5	0.5	1.0	0.5	-0.4	-0.7	1.0
Parametrial fat weight	0.3	0.6	0.9	0.6	-0.5	-0.9	0.9
Pavlov. Cond. lever latency	0.4	0.5	0.7	-0.6	0.7	0.8	-0.8
Pavlov. Cond. magazine entry latency	1.5	2.0	2.5	1.2	-1.3	-1.6	1.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	0.2	-0.0	-0.0
Pavlov. Cond. index score	0.4	0.5	0.7	0.4	-0.5	-0.8	0.8
Pavlov. Cond. latency score	0.4	0.5	0.7	0.5	-0.6	-0.9	0.9
Pavlov. Cond. lever contacts	0.4	0.5	0.7	0.4	-0.6	-0.9	0.9
Pavlov. Cond. magazine entry number	1.8	2.2	2.7	-1.2	1.4	1.7	-1.6
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.3	-0.1	0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.2	-0.3	-0.6	0.7
Pavlov. Cond. response bias	1.1	1.4	2.0	0.8	-1.0	-1.4	1.4
Pavlov. Cond. lever latency	2.3	3.0	3.3	-1.6	1.7	1.8	-1.8
Pavlov. Cond. magazine entry latency	1.0	1.1	1.3	1.1	-1.2	-1.0	1.0
Pavlov. Cond. change in total contacts	0.5	0.6	0.7	0.7	-0.8	-0.8	0.9
Pavlov. Cond. index score	2.0	2.6	2.7	1.5	-1.6	-1.6	1.7
Pavlov. Cond. latency score	1.9	2.3	2.4	1.5	-1.6	-1.5	1.5
Pavlov. Cond. lever contacts	2.8	3.9	4.1	1.9	-2.0	-2.0	2.0
Pavlov. Cond. magazine entry number	0.7	0.9	1.1	-1.0	1.0	0.8	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.2	-0.2	-0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	2.6	1.4	-1.6	-1.6	1.6
Pavlov. Cond. response bias	2.9	4.0	4.3	1.9	-2.0	-2.0	2.1
Time in closed arm before self-admin	4.1	4.7	4.9	2.2	-2.2	-2.1	2.0
Time in closed arm after self-admin	2.5	2.5	3.2	1.8	-1.7	-1.5	1.3
Time in open arm before self-admin	3.0	3.3	3.9	-2.0	1.8	1.8	-1.6
Time in open arm after self-admin	6.2	6.8	8.3	-2.8	2.9	2.4	-2.3
Bone: periosteal estimation	0.0	0.0	0.1	0.2	-0.2	-0.2	0.2
Bone: periosteal perimeter	0.5	0.9	0.9	1.0	-0.9	-0.9	1.0
Bone: post-yield work	0.2	0.3	0.6	-0.1	0.2	0.8	-0.8
Progressive ratio test 1 active lever presses	2.9	3.1	3.2	1.7	-1.8	-1.8	1.8
Progressive ratio test 1 breakpoint	2.6	2.7	2.8	1.6	-1.6	-1.7	1.6
Progressive ratio test 1 inactive lever presses	3.5	3.8	4.1	2.0	-2.0	-2.0	1.8
Progressive ratio test 2 active lever presses	3.3	3.6	4.1	2.0	-1.9	-1.8	1.7
Progressive ratio test 2 breakpoint	4.1	4.6	5.1	2.3	-2.2	-2.1	2.0
Progressive ratio test 2 inactive lever presses	6.8	7.9	9.3	3.1	-2.9	-2.7	2.6
Incentive Sensitization - Responses	1.9	1.9	2.3	1.3	-1.3	-1.5	1.4
Incentive Sensitization - Breakpoint	1.5	1.6	1.8	1.2	-1.2	-1.3	1.3
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.2	-1.1	0.9	0.3	-0.2
Progressive ratio	0.3	0.3	0.5	0.7	-0.7	-0.3	0.3
Food seeking constrained by brief footshock	0.3	0.4	0.6	0.5	-0.6	-0.7	0.6
Seeking ratio, punishment vs. effort	0.3	0.4	0.5	-0.7	0.7	0.5	-0.5
Retroperitoneal fat weight	14.0	46.0	52.8	7.3	-7.0	-6.4	6.3
Reaction time number correct	0.1	0.1	0.4	-0.6	0.5	0.1	-0.1
Reaction time mean minus median	0.0	0.0	0.1	-0.4	0.2	0.1	0.0
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.3	0.1	-0.1	0.2
Reaction time num false alarms	2.9	3.9	4.8	-1.7	1.8	2.2	-2.2
Reaction time num false alarms AUC	3.7	5.2	5.8	-2.1	2.2	2.4	-2.4
Reaction time trials correct on left	0.1	0.1	0.4	-0.6	0.5	0.1	-0.1
Reaction time trials on left	0.1	0.2	0.4	-0.7	0.5	0.1	-0.2
Reaction time mean	0.4	0.5	0.9	0.4	-0.6	-0.8	0.9
Reaction time mean AUC	0.6	0.8	1.4	0.5	-0.7	-1.1	1.2
Median of all reaction times	0.8	1.1	1.6	0.7	-0.9	-1.2	1.3
Reaction time omissions	0.4	0.5	0.6	-0.7	0.6	0.7	-0.7
Reaction time false alarm rate	3.4	4.8	5.9	-1.8	2.0	2.4	-2.4
Reaction time premature initiation rate	0.1	0.2	0.3	0.1	0.1	0.6	-0.6
Reaction time premature initiations	0.2	0.2	0.4	-0.3	0.4	0.6	-0.6
Std. dev. reaction times	0.0	0.0	0.1	-0.1	0.0	-0.2	0.3
Reaction time trials completed	0.1	0.2	0.4	-0.7	0.5	0.1	-0.2
Reaction time trials AUC	0.1	0.1	0.2	-0.5	0.3	-0.0	0.0
Run reversals in cocaine runway, females	2.3	2.3	3.1	1.4	-1.4	-1.8	1.3
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.3	0.4	0.3	-0.7
Latency to leave start box in cocaine runway	0.5	0.6	0.8	-0.7	0.8	0.9	-0.6
Latency to leave start box in cocaine runway, F	0.7	0.8	1.1	-0.8	0.8	1.0	-0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.0	0.0	0.1	0.3
Std. dev. time between licks in bursts	0.3	0.3	0.8	0.9	-0.7	-0.1	0.0
Total sessions with >9 infusions	2.5	2.8	2.9	1.7	-1.7	-1.7	1.7
Short access day 1 total inactive lever presses	0.7	0.8	1.3	1.1	-1.0	-0.7	0.6
Short access day 10 total inactive lever presses	0.7	0.8	1.0	0.7	-0.9	-1.0	0.9
Short access day 1 total infusions	6.3	6.7	6.8	2.6	-2.6	-2.6	2.6
Short access day 10 total infusions	1.8	2.0	2.2	1.4	-1.4	-1.4	1.5
Short access total infusions	3.3	3.7	4.3	1.8	-1.8	-2.0	2.1
Short access day 1 locomotion	0.6	0.7	0.8	0.8	-0.7	-0.8	0.9
Short access day 10 total locomotion	1.5	1.7	2.6	1.6	-1.4	-1.2	0.8
Short access total locomotion	1.1	1.1	1.5	1.2	-1.1	-1.1	0.8
One hour access (0.3 mA shock)	3.6	4.2	4.6	2.1	-2.1	-2.0	1.9
Compulsive drug intake	2.1	2.1	2.6	-1.6	1.5	1.4	-1.4
One hour access (shock baseline)	5.8	6.8	7.7	2.8	-2.6	-2.5	2.5
Social response proportion	3.7	4.0	5.4	-2.3	2.0	1.8	-1.8
Social responses	0.3	0.4	0.9	-0.9	0.6	0.4	-0.3
Social time	6.1	8.0	10.0	-3.2	2.9	2.7	-2.6
Soleus weight	0.4	1.3	1.5	-1.0	1.1	1.2	-1.2
Bone: stiffness	0.5	0.8	1.2	1.1	-1.0	-0.7	0.7
Tibialis anterior weight	1.5	5.3	5.8	-2.4	2.4	2.2	-2.2
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.6	0.6	-0.6	-0.4	0.8
Time to tail flick, vehicle, after self-admin	2.6	2.8	3.8	2.0	-1.9	-1.5	1.2
Time to tail flick, test, before self-admin	0.4	0.4	0.7	0.6	-0.6	-0.4	0.8
Time to tail flick, test, after self-admin	0.7	0.7	1.0	1.0	-1.0	-0.6	0.8
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.3	1.1	-1.2	-0.9	0.5
Delta time to tail flick, test, before/after SA	0.3	0.3	0.4	-0.3	0.4	0.6	-0.7
Tibia length	0.1	0.2	0.3	-0.6	0.3	-0.3	0.4
Ambulatory time before self-admin	0.6	0.7	1.4	0.4	-0.6	-1.2	0.9
Ambulatory time after self-admin	3.0	3.3	5.1	1.4	-1.4	-2.3	2.1
Bone: tissue strength	0.7	0.7	0.8	-0.9	0.8	0.9	-0.9
Total heroin consumption	0.3	0.4	0.6	-0.8	0.6	0.3	-0.6
Bone: trabecular number	0.6	0.9	1.1	0.8	-1.1	-1.0	0.9
Bone: trabecular spacing	0.0	0.0	0.1	0.3	-0.1	-0.2	0.2
Bone: trabecular thickness	0.3	0.4	0.6	0.3	-0.6	-0.8	0.7
Bone: trabecular tissue density	0.6	0.9	1.0	-0.9	1.0	1.0	-0.9
Water consumed over 24 hours	0.5	0.6	0.7	0.8	-0.8	-0.7	0.7
Number of responses in last shaping day	2.6	2.7	2.9	1.6	-1.6	-1.7	1.7